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Th17 cells

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https://www.readbyqxmd.com/read/29909346/kuijieling-regulates-the-differentiation-of-treg-and-th17-cells-to-ameliorate-experimental-colitis-in-rats
#1
Yu Long, Sixin Li, Jingchun Qin, Liwei Xie, Liping Gan, Fengming Jie, Yanli Wu, Yanwu Li, Qun Du
BACKGROUND: Regulatory T (Treg) cells and T helper 17 (Th17) cells play crucial roles in ulcerative colitis (UC). Kuijieling (KJL) is an effective Chinese medicine formula for treating UC in clinic. Kuijieling has shown remedy effect on the imbalance between Treg and Th17 cells. This study aimed to further reveal the exact underlying mechanism of how Kuijieling regulates the differentiation of Treg and Th17 cells in the treatment of UC. METHODS: Colitis was induced by trinitrobenzene sulfonic acid in rats and treated by KJL...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909072/bone-marrow-derived-inflammatory-and-steady-state-dcs-are-different-in-both-functions-and-survival
#2
Wenjie Zhang, Ying Ding, Li Sun, Qing Hong, Yumei Sun, Liangliang Han, Mengting Zi, Yuekang Xu
Dendritic cells (DCs) contain heterogeneous populations, with classical DCs developed at steady state and monocyte-derived DCs mobilized under inflammatory conditions, although their total numbers in vivo are scares. To obtain enough quantity for immunological study or clinical application, we have previously established that bone marrow-derived DCs in the presence of Flt-3L (FL-DCs) or GM-CSF (GM-DCs) in vitro are equivalent to the steady state DCs and inflammatory DCs in vivo respectively. What difference, however, exists between these two most commonly used culture systems in DC functions and survival, and how does it correlate to the division of works by their corresponding counterparts in vivo remain ill-defined...
June 7, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29908907/modulation-of-human-th17-cell-responses-through-complement-receptor-3-cd11-b-cd18-ligation-on-monocyte-derived-dendritic-cells
#3
Johannes Nowatzky, Olivier Manches, Shaukat Ali Khan, Emmanuelle Godefroy, Nina Bhardwaj
OBJECTIVE: Apoptotic cell receptors contribute to the induction of tolerance by modulating dendritic cell function following the uptake of apoptotic cells or microparticles. Dendritic cells that have bound or ingested apoptotic cells produce only low amounts of pro-inflammatory cytokines and fail to prime effector T cell responses. Specifically, ligation of the apoptotic cell receptor CR3 (CD11 b/CD18) on human monocyte-derived dendritic cells (moDC) down-modates proinflammatory cytokine secretion, but the consequences for human Th17 cell homeostasis and effector responses remain unknown...
June 13, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29908492/treatment-of-guillain-barr%C3%A3-syndrome-with-bifidobacterium-infantis-through-regulation-of-t-helper-cells-subsets
#4
Peng Shi, Hongdang Qu, Di Nian, Yuhua Chen, Xiaolin Liu, Qiang Li, Qianqian Li, Chun Wang, Ming Ye, Bo Ma
BACKGROUND: Guillain-Barré syndrome (GBS) is a rare, autoimmune-mediated disease. The use of Bifidobacterium is reportedly effective in alleviating GBS since they act by regulating T helper (Th) cells. OBJECTIVES: In this study, we explored the differentiation of T helper cell subsets in patients with GBS. We also evaluated the effect of GBS on Bifidobacterium levels in patients and the likely protective influence of this bacterium in alleviating the disease in an animal model...
June 13, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29908068/macrophages-in-patients-with-recurrent-endometrial-polyps-could-exacerbate-th17-responses
#5
Yali Zhu, Zhihong Liu, Miaomiao Du, Lisha Yi, Guifang Gong, Xiang Tang
Endometrial polyps (EPs) are outgrowths in the endometrium with unknown etiology. The fact that EPs can often recur after surgical removal suggests that EPs are not induced by random events but by continuous or recurrent processes in the patients. We previously demonstrated that the risk of EP development was positively associated with overactive Th17 responses. However, the requirements of Th17 upregulation are yet unclear. Here, we recruited twenty-six females with symptomatic EP and twenty-four females without EP, and peripheral mononuclear cells were harvested for the examination of circulating immunity...
June 16, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29907866/intestinal-damage-precedes-mucosal-immune-dysfunction-in-siv-infection
#6
Tiffany Hensley-McBain, Alicia R Berard, Jennifer A Manuzak, Charlene J Miller, Alexander S Zevin, Patricia Polacino, Jillian Gile, Brian Agricola, Mark Cameron, Shiu-Lok Hu, Jacob D Estes, R Keith Reeves, Jeremy Smedley, Brandon F Keele, Adam D Burgener, Nichole R Klatt
HIV and pathogenic SIV infection are characterized by mucosal dysfunction including epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial translocation with accompanying inflammation. However, it is unclear how and when these contributing factors occur relative to one another. In order to determine whether any of these features initiates the cycle of damage, we longitudinally evaluated the kinetics of mucosal and systemic T-cell activation, microbial translocation, and Th17 cell and neutrophil frequencies following intrarectal SIV infection of rhesus macaques...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907093/effect-of-administration-of-a-probiotic-preparation-on-gut-microbiota-and-immune-response-in-healthy-women-in-india-an-open-label-single-arm-pilot-study
#7
Ankita Singh, Aditya N Sarangi, Amit Goel, Rajni Srivastava, Rajat Bhargava, Priyanka Gaur, Amita Aggarwal, Rakesh Aggarwal
BACKGROUND: Probiotics have been shown to be useful for the treatment of many disease conditions. These beneficial effects are believed to be mediated by change in the composition of gut microbiota and modulation of the host immune responses. However, the available data on the effect of probiotics on these parameters are quite limited. METHODS: We studied the composition of fecal microbiota, using 16S rRNA sequencing, and host immune responses in peripheral blood (plasma cytokine levels, T cell subsets and in vitro cytokine production after stimulation with anti-CD3/CD28 antibody or lipopolysaccharide) in a group of 14 healthy women at three time-points - before and after administration of a probiotic preparation (a capsule of VSL#3, each containing 112...
June 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29906586/characterization-of-monocyte-subtypes-regarding-their-phenotype-and-development-in-the-context-of-graft-versus-host-disease
#8
Katharina Reinhardt-Heller, Insa Hirschberg, Thomas Vogl, Rupert Handgretinger, Ursula Holzer
Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). In this study, monocyte subtypes were characterized regarding cytokine expression pattern and development in the context of GvHD. Using inflammatory S100 proteins for monocyte stimulation, it could be demonstrated that intermediate monocytes are the main producers of inflammatory cytokines such as IL-6 and TNFα known to be involved in the development of Th17 cells pointing towards an inflammatory phenotype of this monocyte subtype...
June 12, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29906512/mechanisms-of-fibronectin-binding-protein-a-fnbpa-110-263-vaccine-efficacy-in-staphylococcus-aureus-sepsis-versus-skin-infection
#9
Rui Zhang, Sun Li, Xiao-Kai Zhang, Yu Wang, Liu-Yang Yang, Hao Zeng, Da-Peng Yan, Quan-Ming Zou, Qian-Fei Zuo
Increasing rates of life-threatening infections and decreasing susceptibility to antibiotics urge an effective vaccine targeting Staphylococcus aureus. Here we investigate the role of cellular immunity in FnBPA110-263 mediated protection in Staphylococcus aureus infection. This study revealed FnBPA110-263 broadly protected mice from seven FnBPA isotypes strains in the sepsis model. FnBPA110-263 immunized B-cell deficient mice were protected against lethal challenge, while T-cell deficient mice were not. Reconstituting mice with FnBPA110-263 specific CD4+ T-cells conferred antigen specific protection...
June 12, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29904348/berberine-regulates-treg-th17-balance-to-treat-ulcerative-colitis-through-modulating-the-gut-microbiota-in-the-colon
#10
Huantian Cui, Yuzi Cai, Li Wang, Beitian Jia, Junchen Li, Shuwu Zhao, Xiaoqian Chu, Jin Lin, Xiaoyu Zhang, Yuhong Bian, Pengwei Zhuang
Berberine (BBR), an alkaloid isolated from Rhizoma Coptidis, Cortex Phellode , and Berberis , has been widely used in the treatment of ulcerative colitis (UC). However, the mechanism of BBR on UC is unknown. In this study, we investigated the activities of T regulatory cell (Treg) and T helper 17 cell (Th17) in a dextran sulfate sodium (DSS)-induced UC mouse model after BBR administration. We also investigated the changes of gut microbiota composition using 16S rRNA analysis. We also examined whether BBR could regulate the Treg/Th17 balance by modifying gut microbiota...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29903026/serum-ifn-%C3%AE-levels-predict-the-therapeutic-effect-of-mesenchymal-stem-cell-transplantation-in-active-rheumatoid-arthritis
#11
Yi Yang, Xiao He, Rongseng Zhao, Wei Guo, Ming Zhu, Wei Xing, Dongpo Jiang, Chongyang Liu, Xiang Xu
BACKGROUND: To explore the mechanism of the different clinical efficacies of mesenchymal stem cell transplantation (MSCT) and identify a possible serum biomarker for predicting the therapeutic effect of MSCT in rheumatoid arthritis (RA) patients. METHODS: A total of 105 patients with persistently active RA and poor responses to traditional medication were randomly divided into MSCT and control groups. Outcomes were evaluated according to the 28-joint Disease Activity Score and Health Assessment Questionnaire, serological indicators, regulatory T cell (Treg) to T helper 17 (Th17) cell ratio, and inflammatory cytokine levels...
June 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29901407/vaccination-with-a-novel-antigen-specific-tolerizing-dna-vaccine-encoding-ccol2a1-protects-rats-from-experimental-rheumatoid-arthritis
#12
Xiao Zhao, Juan Long, Fei Liang, Nan Liu, Yuying Sun, Yongzhi Xi
Antigen-specific tolerizing DNA vaccines are one of the most promising strategies for rheumatoid arthritis (RA) treatment, and act by inducing potent immune tolerance instead of generalized immunosuppression. Recently, we developed a novel antigen-specific tolerizing DNA vaccine coding for chicken type II collagen (pcDNA-CCOL2A1), and confirmed its potent therapeutic efficacy in an established rat model of collagen-induced arthritis (CIA). Here we report the prophylactic vaccination efficacy of a single 300ug/kg dose of pcDNA-CCOL2A1 against CIA incidence, severity, and onset...
June 14, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29901094/fennel-main-constituent-trans%C3%A2-anethole-treatment-against-lps%C3%A2-induced-acute-lung-injury-by-regulation-of-th17-treg-function
#13
Sichao Zhang, Xi Chen, Ichinkhorloo Devshilt, Qi Yun, Cong Huang, Lijun An, Sosorburam Dorjbat, Xin He
Fennel, commonly used in traditional Chinese medicine, is known as Foeniculum vulgare Mill. And its clinical application has been shown to target many biological systems including gastroenterology, endocrinology, gynecology and respiratory. The main constituent of the fennel essential oil is trans‑anethole, which has been described to have anti‑inflammatory and antibacterial activities. The aim of the present study was to define the anti‑inflammatory influence in acute lung injury (ALI)‑bearing mice...
June 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900057/d-2-hydroxyglutarate-interferes-with-hif-1%C3%AE-stability-skewing-t-cell-metabolism-towards-oxidative-phosphorylation-and-impairing-th17-polarization
#14
Martin Böttcher, Kathrin Renner, Raffaela Berger, Kristin Mentz, Simone Thomas, Zugey Elizabeth Cardenas-Conejo, Katja Dettmer, Peter J Oefner, Andreas Mackensen, Marina Kreutz, Dimitrios Mougiakakos
D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations. D-2HG acting as an oncometabolite promotes proliferation, anoikis, and differentiation block of hematopoietic cells in an autocrine fashion. However, prognostic impact of IDH mutations and high D-2HG levels remains controversial and might depend on the overall mutational context. An increasing number of studies focus on the permissive environment created by AML blasts to promote immune evasion...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29899748/transcription-factor-retinoid-related-orphan-receptor-%C3%AE-t-a-promising-target-for-the-treatment-of-psoriasis
#15
REVIEW
Lipeng Tang, Xiaozhi Yang, Yongxin Liang, Hesong Xie, Zhenhua Dai, Guangjuan Zheng
Psoriasis, which is a common chronic inflammatory skin disease, endangers human health and brings about a major economic burden worldwide. To date, treatments for psoriasis remain unsatisfied because of their clinical limitations and various side effects. Thus, developing a safer and more effective therapy for psoriasis is compelling. Previous studies have explicitly shown that psoriasis is an autoimmune disease that is predominantly mediated by T helper 17 (Th17) cells, which express high levels of interleukin-17 (IL-17) in response to interleukin-23 (IL-23)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29899562/immunome-differences-between-porcine-ileal-and-jejunal-peyer-s-patches-revealed-by-global-transcriptome-sequencing-of-gut-associated-lymphoid-tissues
#16
T Maroilley, M Berri, G Lemonnier, D Esquerré, C Chevaleyre, S Mélo, F Meurens, J L Coville, J J Leplat, A Rau, B Bed'hom, S Vincent-Naulleau, M J Mercat, Y Billon, P Lepage, C Rogel-Gaillard, J Estellé
The epithelium of the intestinal mucosa and the gut-associated lymphoid tissues (GALT) constitute an essential physical and immunological barrier against pathogens. In order to study the specificities of the GALT transcriptome in pigs, we compared the transcriptome profiles of jejunal and ileal Peyer's patches (PPs), mesenteric lymph nodes (MLNs) and peripheral blood (PB) of four male piglets by RNA-Seq. We identified 1,103 differentially expressed (DE) genes between ileal PPs (IPPs) and jejunal PPs (JPPs), and six times more DE genes between PPs and MLNs...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29899268/effect-of-nonsurgical-periodontal-therapy-on-plasma-levels-of-il-17-in-chronic-periodontitis-patients-with-well-controlled-type-ii-diabetes-mellitus-a-clinical-study
#17
Vishnu Jayakumar Sunandhakumari, Arun Sadasivan, Elizabeth Koshi, Aswathy Krishna, Aneesh Alim, Aneesh Sebastian
For years the pathogenesis of periodontitis was under an immunological Th1/Th2 paradigm. Th1 cells are considered to afford protection against the intracellular pathogens. These cells produce the interferons (IFN) that are involved in macrophage activation, which, in turn, plays an important role in phagocytosis, complement fixation, and opsonization. Th2 cells are thought to have evolved as a form of protection against parasitic helminthes. Th17 subset of CD4Not Necessary+ T cells was identified in the year 2005, which added greater complexity to Th function and are pro inflammatory in nature...
June 13, 2018: Dentistry journal
https://www.readbyqxmd.com/read/29896193/relapsing-remitting-multiple-sclerosis-is-characterized-by-a-t-follicular-cell-pro-inflammatory-shift-reverted-by-dimethyl-fumarate-treatment
#18
Vanesa Cunill, Margarita Massot, Antonio Clemente, Carmen Calles, Valero Andreu, Vanessa Núñez, Antonio López-Gómez, Rosa María Díaz, María de Los Reyes Jiménez, Jaime Pons, Cristòfol Vives-Bauzà, Joana Maria Ferrer
Multiple sclerosis (MS) is considered a T cell-mediated autoimmune disease, although several evidences also demonstrate a B cell involvement in its etiology. Follicular T helper (Tfh) cells, a CXCR5-expressing CD4+ T cell subpopulation, are essential in the regulation of B cell differentiation and maintenance of humoral immunity. Alterations in circulating (c)Tfh distribution and/or function have been associated with autoimmune diseases including MS. Dimethyl fumarate (DMF) is a recently approved first-line treatment for relapsing-remitting MS (RRMS) patients whose mechanism of action is not completely understood...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29895377/zinc-aspartate-suppresses-proliferation-and-th1-th2-th17-cytokine-production-of-pre-activated-human-t-cells-in-vitro
#19
Karina Guttek, Linda Wagenbrett, Annegret Reinhold, Kurt Grüngreiff, Dirk Reinhold
The essential trace element zinc, necessary for many biological processes of living organisms, plays a regulatory role in the maintenance of immune functions. Zinc deficiency affects components of both the innate and the adaptive immune system. On the other side, zinc is capable of suppressing activation and proliferation of human T cells. In the present study, we investigated the effect of zinc aspartate (Unizink® ), an approved drug to treat zinc deficiency, on pre-activated human T cells (T cell blasts) in vitro...
September 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29894691/th9-cells-represent-a-unique-subset-of-cd4-t-cells-endowed-with-the-ability-to-eradicate-advanced-tumors
#20
Yong Lu, Qiang Wang, Gang Xue, Enguang Bi, Xingzhe Ma, Aibo Wang, Jianfei Qian, Chen Dong, Qing Yi
The antitumor effector T helper 1 (Th1) and Th17 cells represent two T cell paradigms: short-lived cytolytic Th1 cells and "stem cell-like" memory Th17 cells. We report that Th9 cells represent a third paradigm-they are less-exhausted, fully cytolytic, and hyperproliferative. Only tumor-specific Th9 cells completely eradicated advanced tumors, maintained a mature effector cell signature with cytolytic activity as strong as Th1 cells, and persisted as long as Th17 cells in vivo. Th9 cells displayed a unique Pu...
June 11, 2018: Cancer Cell
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