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https://www.readbyqxmd.com/read/29475096/phenotypic-and-functional-profile-of-th17-and-treg-cells-in-allergic-fungal-sinusitis
#1
Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Neelima Gupta, Sonal Sharma, Naseem Akhter, Vishnampettai G Ramachandran, Shafiul Haque, Sajad Ahmad Dar
Interleukin-17 producing T helper (Th17) and regulatory T cells (Treg) cells have been identified to play a critical role in atopic inflammation. However, conflicting reports on the role of Th17/Treg cells in allergic fungal rhinosinusitis (AFRS) patients of different ethnicities has mystified its pathogenesis. To better understand the pathophysiological mechanisms involved in AFRS, we conducted a prospective, analytical, case-control study involving 40 confirmed immunocompetent AFRS patients and 20 healthy controls...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29473686/alternative-th17-and-cd4-cd25-foxp3-cells-frequency-increase-and-correlate-with-worse-cardiac-function-in-chagas-cardiomyopathy
#2
Mariana S Almeida, Virginia M B Lorena, Carolina de Araújo Medeiros, Wilson Oliveira Junior, Maria da Glória A M Cavalcanti, Silvia M Martins, Clarice N L de Morais
Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease, however, the immunopathologic factors involved haven't been fully elucidated. Therefore, our study aimed to analyze the frequency of CD4+ CD25+ FoxP3+ cells, classic Th17 cells, alternative Th17 cells and IL-17+ B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20), and severe, C (CARD2) (n = 11)...
February 23, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29472922/efficacy-of-t-regulatory-cells-th17-cells-and-the-associated-markers-in-monitoring-tuberculosis-treatment-response
#3
Sonali Agrawal, Om Parkash, Alangudi Natarajan Palaniappan, Ashok Kumar Bhatia, Santosh Kumar, Devendra Singh Chauhan, M Madhan Kumar
Treatment monitoring is an essential aspect for tuberculosis (TB) disease management. Sputum smear microscopy is the only available tool for monitoring, but it suffers from demerits. Therefore, we sought to evaluate markers and cellular subsets of T regulatory (Treg) cells and T helper (Th) 17 cells in pulmonary TB patients (PTB) for TB treatment monitoring. Peripheral blood mononuclear cells (PBMCs) were stimulated in vitro (with purified protein derivative (PPD)) overnight which was followed by a polychromatic flow cytometry approach to study Treg and Th17 markers and cellular subsets in PTB ( n  = 12) undergoing antituberculous treatment (ATT)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29469612/the-atypical-chemokine-receptor-ackr2-drives-pulmonary-fibrosis-by-tuning-influx-of-ccr2-and-ccr5-ifn%C3%AE-producing-%C3%AE-%C3%AE-t-cells-in-mice
#4
Remo Castro Russo, Benedetta Savino, Massimiliano Mirolo, Chiara Buracchi, Giovanni Germano, Achille Anselmo, Luca Zammataro, Fabio Pasqualini, Alberto Mantovani, Massimo Locati, Mauro M Teixeira
RATIONALE: Chemokines coordinate lung inflammation and fibrosis by acting on chemokine receptors expressed on leukocytes and other cell types. Atypical chemokine receptors (ACKRs) bind, internalize and degrade chemokines, tuning homeostasis and immune responses. ACKR2 recognizes and decreases levels of inflammatory CC chemokines. The role of ACKR2 in fibrogenesis is unknown. OBJECTIVE: Investigate the role of ACKR2 in the context of pulmonary fibrosis. METHODS: The effects of ACKR2 expression and deficiency during inflammation and fibrosis were analyzed using a bleomycin-model of fibrosis, ACKR2-deficient mice, bone marrow chimeras and antibody-mediated leukocyte depletion...
February 22, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29467858/effects-of-iodine-131-radiotherapy-on-th17-tc17-and-treg-th17-cells-of-patients-with-differentiated-thyroid-carcinoma
#5
Lixia Zhang, Jinyan Chen, Caiyun Xu, Lili Qi, Yan Ren
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells serve important roles in a number of inflammatory and autoimmune diseases. The aim of the present study was to examine the distribution of Th17, Tc17 and Treg cells in patients with differentiated thyroid cancer (DTC) prior to as well as 7, 30 and 90 days following radioactive iodine-131 (131 I) therapy, and to elucidate the probable effects of131 I therapy on Th17/Tc17 and Treg/Th17 cells in patients with DTC. A total of 40 patients with DTC (26 female; 14 male) between the ages of 24 and 72 years, as well as 13 age- and sex-matched healthy subjects were included in this study...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29467767/identification-of-casz1-as-a-regulatory-protein-controlling-t-helper-cell-differentiation-inflammation-and-immunity
#6
Natarajan Bhaskaran, Zhihui Liu, Senthil S Saravanamuthu, Chunhua Yan, Ying Hu, Lijin Dong, Peggy Zelenka, Lixin Zheng, Vassili Bletsos, Rachel Harris, Brenna Harrington, Aaron Weinberg, Carol J Thiele, Fengchun Ye, Pushpa Pandiyan
While T helper (Th) cells play a crucial role in host defense, an imbalance in Th effector subsets due to dysregulation in their differentiation and expansion contribute to inflammatory disorders. Here, we show that Casz1, whose function is previously unknown in CD4+ T cells, coordinates Th differentiation in vitro and in vivo . Casz1 deficiency in CD4+ T cells lowers susceptibility to experimental autoimmune encephalomyelitis, consistent with the reduced frequency of Th17 cells, despite an increase in Th1 cells in mice...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467654/the-p2x7-receptor-in-inflammatory-diseases-angel-or-demon
#7
REVIEW
Luiz E B Savio, Paola de Andrade Mello, Cleide Gonçalves da Silva, Robson Coutinho-Silva
Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the extracellular milieu, being massively released by stressed or dying cells. Once outside the cells, ATP and related nucleotides/nucleoside generated by ectonucleotidases mediate a high evolutionary conserved signaling system: the purinergic signaling, which is involved in a variety of pathological conditions, including inflammatory diseases. Extracellular ATP has been considered an endogenous adjuvant that can initiate inflammation by acting as a danger signal through the activation of purinergic type 2 receptors-P2 receptors (P2Y G-protein coupled receptors and P2X ligand-gated ion channels)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29467007/enhanced-glycolysis-contributes-to-the-pathogenesis-of-experimental-autoimmune-neuritis
#8
Ru-Tao Liu, Min Zhang, Chun-Lin Yang, Peng Zhang, Na Zhang, Tong Du, Meng-Ru Ge, Long-Tao Yue, Xiao-Li Li, Heng Li, Rui-Sheng Duan
BACKGROUND: With the recognition of the key roles of cellular metabolism in immunity, targeting metabolic pathway becomes a new strategy for autoimmune disease treatment. Guillain-Barré syndrome (GBS) is an acute immune-mediated inflammatory demyelinating disease of the peripheral nervous system, characterized by inflammatory cell infiltration. These inflammatory cells, including activated macrophages, Th1 cells, and Th17 cells, generally undergo metabolic reprogramming and rely mainly on glycolysis to exert functions...
February 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29463741/transcriptional-factor-icer-promotes-glutaminolysis-and-the-generation-of-th17-cells
#9
Michihito Kono, Nobuya Yoshida, Kayaho Maeda, George C Tsokos
Glutaminolysis is a well-known source of energy for effector T cells but its contribution to each T cell subset and the mechanisms which are responsible for the control of involved metabolic enzymes are not fully understood. We report that Th17 but not Th1, Th2, or Treg cell induction in vitro depends on glutaminolysis and the up-regulation of glutaminase 1 (Gls1), the first enzyme in the glutaminolysis pathway. Both pharmacological and siRNA-based selective inhibition of Gls1 reduced in vitro Th17 differentiation and reduced the CD3/TCR-mediated increase of the mammalian target of rapamycin complex 1 activity...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29462298/th17-cells-differentiated-with-mycelial-membranes-of-candida-albicans-prevent-oral-candidiasis
#10
Sonoko Tasaki, Tamaki Cho, Jun-Ichi Nagao, Shojiro Ikezaki, Yuka Narita, Ken-Ichi Arita-Morioka, Kanae Yasumatsu, Keita Toyoda, Hiroshi Kojima, Yoshihiko Tanaka
Candida albicans is a human commensal and causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the determination of T cell antigens remains little known. Our final goal is to find out the effective T cell antigens of C. albicans responsible for immunotherapy against candidiasis. Here, we prepared some fractions including cytosol, membrane, and cell wall from each yeast and mycelial form-cell. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells to IL-17A producing Th17 cells...
February 15, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29461617/jak-stat5-signaling-pathway-inhibitor-ruxolitinib-reduces-airway-inflammation-of-neutrophilic-asthma-in-mice-model
#11
R-F Li, G-F Wang
OBJECTIVE: The aim of this study was to explore the role of JAK/STAT signaling pathway inhibitor Ruxolitinib in neutrophilic airway inflammation and its possible immunological mechanism. MATERIALS AND METHODS: A total of 60 female C57BL/6 mice were randomly divided into neutrophilic asthma (NA) group, Ruxolitinib-treated (Ruxo) group and control (Con) group. Mice in NA and Ruxo groups were sensitized with ovalbumin (OVA) and excited to establish mice models of asthma...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29460148/impact-of-vitamin-d-deficiency-on-clinical-parameters-in-treatment-na%C3%A3-ve-rheumatoid-arthritis-patients
#12
Yang Liu, Hongyan Wen
OBJECTIVE: To determine if patients with rheumatoid arthritis (RA) are at risk of vitamin D deficiency and whether the levels of vitamin D are correlated with clinical parameters in RA. METHODS: A total of 280 treatment-naïve RA patients, and 140 age- and sex-matched healthy volunteers were enrolled. Serum levels of 1,25-dihydroxycholecalciferol (1,25(OH)2 D3 ), the active form of vitamin D, were measured by enzyme-linked immunosorbent assay (ELISA). Concentrations of 1,25(OH)2 D3 less than 25 ng/mL were defined as insufficient...
February 19, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29460021/the-role-of-tnf-family-molecules-light-in-cellular-interaction-between-airway-smooth-muscle-cells-and-t-cells-during-chronic-allergic-inflammation
#13
Fei Shi, Yi Xiong, Yarui Zhang, Chen Qiu, Manhui Li, Aijun Shan, Ying Yang, Binbin Li
Interaction between T cells and airway smooth muscle (ASM) cells has been identified as an important factor in the development of asthma. LIGHT (known as TNFSF14) -mediated signaling likely contributes to various inflammatory disorders and airway remodeling. The objective of this study was to investigate the roles of LIGHT-mediated pathways in the interaction between ASM cells and T cells during chronic allergic inflammation. Mice were sensitized and challenged by ovalbumin (OVA) to induce chronic airway allergic inflammation...
February 19, 2018: Inflammation
https://www.readbyqxmd.com/read/29459717/silibinin-alleviates-inflammation-and-induces-apoptosis-in-human-rheumatoid-arthritis-fibroblast-like-synoviocytes-and-has-a-therapeutic-effect-on-arthritis-in-rats
#14
W W Tong, C Zhang, T Hong, D H Liu, C Wang, J Li, X K He, W D Xu
Silibinin, a natural polyphenolic flavonoid, possesses anti-oxidant, anti-inflammation and anti-cancer properties. The present study was designed to investigate the effects of silibinin on rheumatoid arthritis (RA) pathogenesis-related cells and collagen-induced arthritis (CIA) and further explore the potential underlying mechanisms. Our results showed that silibinin suppressed cell viability and increased the percentage of apoptotic RA-fibroblast-like synoviocytes (FLS). Furthermore, the production of inflammatory cytokines in RA-FLS and a CIA rat model was effectively inhibited by silibinin...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29456737/distinctive-profiles-of-tumor-infiltrating-immune-cells-and-association-with-intensity-of-infiltration-in-colorectal-cancer
#15
Yugang Wu, Lei Yuan, Qicheng Lu, Haiyan Xu, Xiaozhou He
Tumor-infiltrating immune cells are heterogeneous and consist of characteristic compartments, including T helper (Th)1 and regulatory T (Treg) cells that exhibit distinctive biological functions. The present study investigated the profile of infiltrating immune cells from surgically removed tumor tissues from patients with colorectal cancer. The characteristic transcription factors of Th1 and Th2 cells, Treg cells, Th17 cells and T follicular helper (Tfh) cells were analyzed. The results demonstrated that a marked increased number of Treg cells presented in tumor infiltrates when compared with non-tumor adjacent tissues...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456692/effects-of-th17-treg-cell-imbalance-on-hiv-replication-in-patients-with-aids-complicated-with-tuberculosis
#16
Yanshuang Li, Weijia Sun
The purpose of this study was to determine the effect of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis (TB). We selected 32 patients with AIDS combined with TB infection in our hospital and 30 healthy individual as controls. The Th17/Treg ratio in peripheral blood lymphocytes was detected by flow cytometry. Compared with healthy subjects, Th17 cells first declined in HIV patients with TB, but gradually increased over the course of the disease. Treg showed an increasing trend in HIV patients with TB...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456158/autologous-ipsc-based-vaccines-elicit-anti-tumor-responses-in-vivo
#17
Nigel G Kooreman, Youngkyun Kim, Patricia E de Almeida, Vittavat Termglinchan, Sebastian Diecke, Ning-Yi Shao, Tzu-Tang Wei, Hyoju Yi, Devaveena Dey, Raman Nelakanti, Thomas P Brouwer, David T Paik, Idit Sagiv-Barfi, Arnold Han, Paul H A Quax, Jaap F Hamming, Ronald Levy, Mark M Davis, Joseph C Wu
Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antigens, and we show here a proof of principle for using irradiated iPSCs in autologous anti-tumor vaccines. In a prophylactic setting, iPSC vaccines prevent tumor growth in syngeneic murine breast cancer, mesothelioma, and melanoma models...
February 8, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29454913/restoring-th17-treg-balance-via-modulation-of-stat3-and-stat5-activation-contributes-to-the-amelioration-of-chronic-obstructive-pulmonary-disease-by-bufei-yishen-formula
#18
Peng Zhao, Jiansheng Li, Yange Tian, Jing Mao, Xuefang Liu, Suxiang Feng, Junzi Li, Qingqing Bian, Huige Ji, Lanxi Zhang
ETHNOPHARMACOLOGY RELEVANCE: Bufei Yishen formula (BYF), a Traditional Chinese Medicine (TCM), has been extensively applied in clinical treatment of chronic obstructive pulmonary disease (COPD) and provides an effective treatment strategy for the syndrome of lung-kidney qi deficiency in COPD patients. Here, we investigated its anti-COPD mechanism in COPD rats in relation to the balance between T helper (Th) 17 cells and regulatory T (Treg) cells. METHODS: Rat model of cigarette smoke- and bacterial infection-induced COPD was established, and orally treated with BYF for 12 consecutive weeks...
February 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29454646/alteration-of-ccr6-cd95-cd4-na%C3%A3-ve-t-cells-in-hiv-1-infected-patients-implication-for-clinical-practice
#19
Hong Sun, Wenqing Geng, Hualu Cui, Guoxin Liang, Yajing Fu, Zining Zhang, Yongjun Jiang, Haibo Ding, Junjie Xu, Hong Shang
The profound deficiency of Th17 cells contributes to HIV disease progression. The mechanisms of their perturbation remain unclear. Recently, CCR6+ CD95+ CD4+ naïve T cells (CCR6+ CD95+ CD4+ TNA ), identified as pre-committed Th17 precursors, were recognized as a subpopulation of CD4+ T cells with stem cell properties. Following phenotypical identification, we evaluated their level in patients during chronic HIV infection and following antiretroviral therapy (ART) using flow cytometry. The levels of CCR6+ CD95+ CD4+ TNA were decreased during chronic HIV infection and correlated with CD4+ T cell counts...
February 10, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29454234/diarylheptanoid-from-rhizomes-of-curcuma-kwangsiensis-dck-inhibited-imiquimod-induced-dendritic-cells-activation-and-th1-th17-differentiation
#20
Qing Liu, Wei Yin, Ling Han, Jiaoyan Lv, Bingji Li, Yuli Lin, Qingsheng Mi, Rui He, Chuanjian Lu
BACKGROUND AND OBJECT: Dendritic cells (DCs) are critical for initiating the activation and differentiation of T cells in inflammatory diseases including psoriasis. Curcuma kwangsiensis S.G. Lee & C.F. Liang is a herb for treating psoriasis and we previously found Diarylheptanoid from rhizomes of Curcuma kwangsiensis (DCK) inhibited keratinocytes proliferation. However, it is unknown whether DCK influences DC functions. Thus we aimed to explore whether DCK affect the major immunological functions of DCs...
February 14, 2018: International Immunopharmacology
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