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https://www.readbyqxmd.com/read/29780578/towards-the-development-of-day-one-competences-in-veterinary-behaviour-medicine-survey-of-veterinary-professionals-experience-in-companion-animal-practice-in-ireland
#1
Olwen Golden, Alison J Hanlon
Background: Veterinary behaviour medicine should be a foundation subject of the veterinary curriculum because of its wide scope of applications to veterinary practice. Private practitioners are likely to be the primary source of information on animal behaviour for most pet owners, however studies indicate that behavioural issues are not frequently discussed during companion animal consultations and many practitioners lack confidence in dealing with behavioural problems, likely due to poor coverage of this subject in veterinary education...
2018: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29752664/patient-related-factors-predicting-workspace-conditions-during-laparoscopic-bariatric-surgery
#2
Paola Aceto, Cristina Modesti, Teresa Sacco, Roberto De Cicco, Valter Perilli, Marco Raffaelli, Carlo Lai, Liliana Sollazzi
BACKGROUND: Previous studies have focused on the role of deep neuromuscular blockade (NMB) in improving surgical conditions during laparoscopic bariatric surgery. However, a wide inter-individual variability has been noted. The aim of this study was to identify patient-related factors affecting surgeon satisfaction with the surgical space and surgery duration in laparoscopic bariatric surgery under deep NMB. METHODS: One hundred eighty-five patients scheduled for laparoscopic gastric bypass were enrolled...
May 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29744667/vagus-nerve-stimulation-exerts-cardioprotection-against-myocardial-ischemia-reperfusion-injury-predominantly-through-its-efferent-vagal-fibers
#3
Watthana Nuntaphum, Wanpitak Pongkan, Suwakon Wongjaikam, Savitree Thummasorn, Pongpan Tanajak, Juthamas Khamseekaew, Kannaporn Intachai, Siriporn C Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Vagus nerve stimulation (VNS) has been shown to exert cardioprotection against myocardial ischemia/reperfusion (I/R) injury. However, whether the cardioprotection of VNS is mainly due to direct activation through its ipsilateral efferent fibers (motor) rather than indirect effects mediated by the afferent fibers (sensory) have not been clearly understood. We hypothesized that VNS exerts cardioprotection predominantly through its efferent vagal fibers. Thirty swine (30-35 kg) were randomized into five groups: I/R no VNS (I/R), and left mid-cervical VNS with both vagal trunks intact (LC-VNS), with left vagus nerve transection (LtVNX), with right vagus nerve transection (RtVNX) and with atropine pretreatment (Atropine), respectively...
May 9, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29742457/some-technical-issues-of-vagal-nerve-stimulation-an-approach-using-a-hippocampal-formation-theta-rhythm
#4
Adam Broncel, Renata Bocian, Paulina Kłos-Wojtczak, Jan Konopacki
Previously, we have demonstrated that hippocampal (HPC) theta rhythm can be produced, depending on current intensity, directly during vagal nerve stimulation (VNS) or with a time delay following stimulation. This suggests that theta EEG pattern can also be used as a bio-indicator of the efficiency of VNS. In the present study, we focused on three specific, technical issues related to the stimulation procedure of the vagal nerve: i/does the type of the electrode used for VNS and the technique of its implantation affect the parameters of the HPC theta rhythm? ii/does the type of electrode used determine the current intensity threshold of VNS-induced HPC theta? iii/is the repeatability of the VNS effect determined by the type of electrode used? We demonstrated that a platinum-iridium cuff electrode offers some important advantages over a tungsten electrode...
May 6, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29740975/similarities-between-the-responses-to-ant-dbs-and-prior-vns-in-refractory-epilepsy
#5
Toni Kulju, Joonas Haapasalo, Kai Lehtimäki, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: Neurostimulation has offered new treatment options in refractory epilepsy, first with vagus nerve stimulation (VNS) and more recently with deep brain stimulation (DBS). There is a lack of previous detailed data assessing the relationship between VNS and ANT-DBS. The aim of this study was to investigate the potential correlation between therapeutic responses to VNS and ANT-DBS. MATERIALS AND METHODS: A total of 11 patients with previous VNS therapy underwent ANT-DBS implantation...
May 8, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29738985/single-center-long-term-results-of-vagus-nerve-stimulation-for-epilepsy-a-10-17-year-follow-up-study
#6
Jan Chrastina, Zdeněk Novák, Tomáš Zeman, Jitka Kočvarová, Martin Pail, Irena Doležalová, Jiří Jarkovský, Milan Brázdil
PURPOSE: The paper presents a long-term follow-up study of VNS patients, analyzing seizure outcome, medication changes, and surgical problems. METHOD: 74 adults with VNS for 10 to 17 years were evaluated yearly as: non-responder - NR (seizure frequency reduction <50%), responder - R (reduction ≥ 50% and <90%), and 90% responder - 90R (reduction ≥ 90%). Delayed R or 90R (≥ 4 years after surgery), patients with antiepileptic medication changes and battery or complete system replacement were identified...
April 30, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29716020/column-generation-algorithms-for-virtual-network-embedding-in-flexi-grid-optical-networks
#7
Rongping Lin, Shan Luo, Jingwei Zhou, Sheng Wang, Bin Chen, Xiaoning Zhang, Anliang Cai, Wen-De Zhong, Moshe Zukerman
Network virtualization provides means for efficient management of network resources by embedding multiple virtual networks (VNs) to share efficiently the same substrate network. Such virtual network embedding (VNE) gives rise to a challenging problem of how to optimize resource allocation to VNs and to guarantee their performance requirements. In this paper, we provide VNE algorithms for efficient management of flexi-grid optical networks. We provide an exact algorithm aiming to minimize the total embedding cost in terms of spectrum cost and computation cost for a single VN request...
April 16, 2018: Optics Express
https://www.readbyqxmd.com/read/29712784/temporal-response-properties-of-accessory-olfactory-bulb-neurons-limitations-and-opportunities-for-decoding
#8
Michal Yoles-Frenkel, Anat Kahan, Yoram Ben-Shaul
The vomeronasal system (VNS) is a major vertebrate chemosensory system that functions in parallel to the main olfactory system (MOS). Despite many similarities, the two systems dramatically differ in the temporal domain. While MOS responses are governed by breathing and follow a sub-second temporal scale, VNS responses are uncoupled from breathing and evolve over seconds. This suggests that the contribution of response dynamics to stimulus information will differ between these systems. While temporal dynamics in the MOS are widely investigated, similar analyses in the AOB are lacking...
April 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29709876/chronic-vagus-nerve-stimulation-reverses-heart-rhythm-complexity-in-patients-with-drug-resistant-epilepsy-an-assessment-with-multiscale-entropy-analysis
#9
Hongyun Liu, Zhao Yang, Fangang Meng, Lei Huang, Wei Qu, Hongwei Hao, Jianguo Zhang, Luming Li
OBJECTIVE: Vagus nerve stimulation (VNS) is an adjunctive treatment in drug-resistant epilepsy. The alterations in heart rate dynamics through VNS are not well understood. This study aimed to determine changes in heart rhythm complexity in association with VNS and to relate the findings to the outcome of VNS treatment in patients with drug-resistant epilepsy. METHODS: We prospectively analyzed 32 patients with drug-resistant epilepsy, who underwent VNS implantation, and 32 age- and sex-matched healthy control subjects...
April 26, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29705856/sculpting-the-sculptors-methods-for-studying-the-fetal-cholinergic-signaling-on-systems-and-cellular-scales
#10
Martin G Frasch, Patrick Burns, Javier Benito, Marina Cortes, Mingju Cao, Gilles Fecteau, André Desrochers
The non-neuronal, immunological effects of the cholinergic signaling are exerted on the system's scale of observation via the vagus nerve and on the cellular scale via α7 nicotinic acetylcholine receptor (nAChR) signaling in myeloid cells of the periphery or brain's microglia and astrocytes. The developmental effects of such multi-scale signaling can be conceived of as an example of psychoneuroimmunological (PNI) homeokinesis and, while reported in the literature, are not yet systematically well studied. To be better understood, the intricacy of the multi-scale interactions requires relevant preclinical animal models...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29702412/vagus-nerve-stimulation-for-6-to-12-year-old-children-with-refractory-epilepsy-impact-on-seizure-frequency-and-parenting-stress-index
#11
Hueng-Chuen Fan, Ting-Rong Hsu, Kai-Ping Chang, Shyi-Jou Chen, Jeng-Dau Tsai
OBJECTIVES: Refractory epilepsy (RE) is frequently associated with neuropsychological impairment in children and may disrupt their social development. Vagus nerve stimulation (VNS) had been reported to have beneficial effects on behavioral outcomes. The aim of this study was to compare Parenting Stress Index (PSI) scores before and after VNS device implantation in children with RE, especially those who experienced seizure frequency reduction. METHODS: We conducted a one-group pretest-posttest study in school age children with RE...
April 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29702409/clinical-outcomes-of-vns-therapy-with-aspiresr-%C3%A2-including-cardiac-based-seizure-detection-at-a-large-complex-epilepsy-and-surgery-centre
#12
Preci Hamilton, Imad Soryal, Prince Dhahri, Welege Wimalachandra, Anna Leat, Denise Hughes, Nicole Toghill, James Hodson, Vijay Sawlani, Tom Hayton, Shanika Samarasekera, Manny Bagary, Dougall McCorry, Ramesh Chelvarajah
PURPOSE: To compare the efficacy of AspireSR® to preceding VNS battery models for battery replacements, and to determine the efficacy of the AspireSR® for new implants. METHODS: Data were collected retrospectively from patients with epilepsy who had VNS AspireSR® implanted over a three-year period between June 2014 and June 2017 by a single surgeon. Cases were divided into two cohorts, those in whom the VNS was a new insertion, and those in whom the VNS battery was changed from a previous model to AspireSR® ...
March 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29692707/vagus-nerve-stimulation-vns-and-other-augmentation-strategies-for-therapy-resistant-depression-trd-review-of-the-evidence-and-clinical-advice-for-use
#13
REVIEW
Helge H O Müller, Sebastian Moeller, Caroline Lücke, Alexandra P Lam, Niclas Braun, Alexandra Philipsen
In addition to electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), vagus nerve stimulation (VNS) is one of the approved neurostimulation tools for treatment of major depression. VNS is particularly used in therapy-resistant depression (TRD) and exhibits antidepressive and augmentative effects. In long-term treatment, up to two-thirds of patients respond. This mini-review provides a comprehensive overview of augmentation pharmacotherapy and neurostimulation-based treatment strategies, with a special focus on VNS in TRD, and provides practical clinical advice for how to select TRD patients for add-on neurostimulation treatment strategies...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29677548/combination-of-curcumin-and-vagus-nerve-stimulation-attenuates-cerebral-ischemia-reperfusion-injury-induced-behavioral-deficits
#14
Jian Xu, Xinjuan Kong, Hong Xiu, Yihe Dou, Zeyu Wu, Peng Sun
AIM: Previous studies indicated that cerebral ischemia/reperfusion injury (CI/RI) could induce behavioral deficits. Single treatment of vagus nerve stimulation (VNS) or curcumin is reported to restore CI/RI-induced behavioral deficits. However, the synergic effect remains unclear. MATERIALS AND METHODS: Rats were divided into 6 groups: sham, CI/RI, VNS, CI/RI + VNS, VNS + curcumin and CI/RI + VNS + curcumin groups. Each group was further divided into three or four subgroups for further assessments...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29675810/neurostimulation-for-memory-enhancement-in-epilepsy
#15
REVIEW
Stephen Meisenhelter, Barbara C Jobst
PURPOSE OF REVIEW: Memory is one of the top concerns of epilepsy patients, but there are no known treatments to directly alleviate the memory deficits associated with epilepsy. Neurostimulation may provide new therapeutic tools to enhance memory in epilepsy patients. Here, we critically review recent investigations of memory enhancement using transcranial electrical stimulation (tES), transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), chronic intracranial stimulation, and acute intracranial stimulation...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29670050/epilepsy-and-neuromodulation-randomized-controlled-trials
#16
Churl-Su Kwon, Valeria Ripa, Omar Al-Awar, Fedor Panov, Saadi Ghatan, Nathalie Jetté
Neuromodulation is a treatment strategy that is increasingly being utilized in those suffering from drug-resistant epilepsy who are not appropriate for resective surgery. The number of double-blinded RCTs demonstrating the efficacy of neurostimulation in persons with epilepsy is increasing. Although reductions in seizure frequency is common in these trials, obtaining seizure freedom is rare. Invasive neuromodulation procedures (DBS, VNS, and RNS) have been approved as therapeutic measures. However, further investigations are necessary to delineate effective targeting, minimize side effects that are related to chronic implantation and to improve the cost effectiveness of these devices...
April 18, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29665520/treatment-resistant-depression-and-suicidality
#17
REVIEW
Isidoor O Bergfeld, Mariska Mantione, Martijn Figee, P Richard Schuurman, Anja Lok, Damiaan Denys
BACKGROUND: Thirty percent of patients with treatment-resistant depression (TRD) attempt suicide at least once during their lifetime. However, it is unclear what the attempted and completed suicide incidences are in TRD patients after initiating a treatment, and whether specific treatments increase or decrease these incidences. METHODS: We searched PubMed systematically for studies of depressed patients who failed at least two antidepressant therapies and were followed for at least three months after initiating a treatment...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29661724/variation-in-nuclear-size-and-pd-l2-positivity-correlate-with-aggressive-chromophobe-renal-cell-carcinoma
#18
Mohamed E Mostafa, Amrou Abdelkader, Naoto Kuroda, Delia Pérez-Montiel, Anjishnu Banerjee, Ondrej Hes, Kenneth A Iczkowski
Chromophobe renal cell carcinoma (CRCC) is not amenable to International Society for Urologic Pathology-endorsed nucleolar grading. Novel grading approaches were proposed, but the rarity of adverse pathology hampers their discriminatory value. We investigate simple linear micrometer measurements and a proposed immunostain in CRCCs. 32 patients' CRCCs were studied: 12 adverse cases (stage pT3, recurrence, or metastasis), 15 controls (stage ≤pT2, no recurrence or metastasis after >3 years), and 8 metastases (3 were paired with primary adverse cases)...
January 10, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29651891/use-of-vagus-nerve-stimulator-on-children-with-primary-generalized-epilepsy
#19
William P Welch, Bilal Sitwat, Yoshimi Sogawa
OBJECTIVE: To describe the response to vagus nerve stimulator (VNS) in otherwise neurotypical children with medically intractable primary generalized epilepsy. METHODS: Retrospective chart review of patients who underwent vagus nerve stimulator surgery between January 2011 and December 2015. RESULTS: Eleven patients were identified. Median follow-up duration was 2.5 years (1.2-8.4 years). Prior to vagus nerve stimulator surgery, all patients had at least 1 seizure per week, and 7/11 (64%) had daily seizures...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29617062/radiofrequency-thermocoagulation-of-the-ganglion-impar-for-coccydynia-management-long-term-effects
#20
Atilla Kırcelli, Emre Demirçay, Ömer Özel, Ilker Çöven, Semra Işık, Erdinç Civelek, Serdar Kabataş
OBJECTIVE: To investigate the short- and long-term effects of ganglion impar radiofrequency thermocoagulation (RFT) treatment in patients with chronic coccydynia. MATERIALS-METHODS: We retrospectively analyzed the medical records of patients who underwent RFT of the ganglion impar between 2009 and 2011. Pain intensity visual numeric scale (VNS) scores and Euroqol 5D (EQ-5D) index scores were recorded pre-intervention and post-intervention at the 1st, 6th, and 12th months...
April 4, 2018: Pain Practice: the Official Journal of World Institute of Pain
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