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https://www.readbyqxmd.com/read/28800036/improved-outcomes-of-cardiopulmonary-resuscitation-in-rats-treated-with-vagus-nerve-stimulation-and-its-potential-mechanism
#1
Peng Sun, Jiangang Wang, Shen Zhao, Zhengfei Yang, Ziren Tang, Navami Ravindra, Jennifer Bradley, Joseph P Ornato, Mary Ann Peberdy, Wanchun Tang
Studies have demonstrated that vagus nerve stimulation (VNS) reduces ischemia/reperfusion (I/R) injury. In this study, we investigated the protective effects of VNS in a rat model of cardiopulmonary resuscitation (CPR). We further investigated whether the beneficial effects of VNS were dependent on the alpha 7 nicotinic acetylcholine receptor (α7nAChR). Forty animals were randomized into 4 groups and all underwent CPR (n = 10 each): (1) CPR alone (control); (2) VNS during CPR; (3) α7nAChR antagonist methyllycaconitine citrate (MLA) with VNS; (4) α7nAChR agonist 3-(2, 4-dimethoxybenzylidene) anabaseine (GTS-21) without VNS...
August 9, 2017: Shock
https://www.readbyqxmd.com/read/28745303/extracellular-ph-monitoring-for-use-in-closed-loop-vagus-nerve-stimulation
#2
Simon C Cork, Amir Eftekhar, Khalid B Mirza, James V Gardiner, Stephen R Bloom, Christofer Toumazou
OBJECTIVE: Vagal nerve stimulation (VNS) has shown potential benefits for obesity treatment; however current devices lack physiological feedback, which limit their efficacy. Changes in extracellular pH (pH<sub>e</sub>) have shown to be correlated with neural activity, but have traditionally been measured with glass microelectrodes, which limit their in vivo applicability. APPROACH: Iridium oxide has previously been shown to be sensitive to fluctuations in pH and is biocompatible...
July 26, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28721049/the-potential-role-of-vagus-nerve-stimulation-in-the-treatment-of-hiv-associated-depression-a-review-of-literature
#3
REVIEW
William C Nicholson, Mirjam-Colette Kempf, Linda Moneyham, David E Vance
Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28719827/mixed-evidence-for-the-potential-of-non-invasive-transcutaneous-vagal-nerve-stimulation-to-improve-the-extinction-and-retention-of-fear
#4
A M Burger, B Verkuil, H Fenlon, L Thijs, L Cools, H C Miller, B Vervliet, I Van Diest
Extinction memories are fragile and their formation has been proposed to partially rely on vagus nerve activity. We tested whether stimulating the auricular branch of the vagus (transcutaneous VNS; tVNS) accelerates extinction and reduces spontaneous recovery of fear. Forty-two healthy students participated in a 3-day fear conditioning study, where we tested fear acquisition (day 1), fear extinction (day 2) and the retention of the extinction memory (day 3). During extinction, participants were randomly allocated to receive tVNS or sham stimulation concurrently with each CS presentation...
July 8, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28709124/we-could-predict-good-responders-to-vagus-nerve-stimulation-a-surrogate-marker-by-slow-cortical-potential-shift
#5
Borgil Bayasgalan, Masao Matsuhashi, Tomoyuki Fumuro, Haruhiko Nohira, Naoki Nakano, Koji Iida, Masaya Katagiri, Akihiro Shimotake, Riki Matsumoto, Takayuki Kikuchi, Takeharu Kunieda, Amami Kato, Ryosuke Takahashi, Akio Ikeda
OBJECTIVE: We investigated whether vagus nerve stimulation (VNS) induces a positive shift of slow cortical potentials (SCPs) in patients with >50% seizure reduction (responders) but not in non-responders. METHODS: We analyzed routine clinical electroencephalograms (EEGs) from 24 patients who were undergoing seizure treatment by VNS. The patients were divided into 2 groups by hardware time constant (TC) of EEG: the TC 10-s group (10 patients) and TC 2-s group (14 patients)...
June 15, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28698761/vagus-nerve-stimulation
#6
REVIEW
Hakan Ekmekçi, Hülagu Kaptan
BACKGROUND: The vagus nerve stimulation (VNS) is an approach mainly used in cases of intractable epilepsy despite all the efforts. Also, its benefits have been shown in severe cases of depression resistant to typical treatment. AIM: The aim of this study was to present current knowledge of vagus nerve stimulation. MATERIAL AND METHODS: A new value has emerged just at this stage: VNS aiming the ideal treatment with new hopes. It is based on the placement of a programmable generator on the chest wall...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28694158/implication-of-the-vagus-nerve-in-breathing-pattern-during-sequential-swallowing-in-rats
#7
Yacine Ouahchi, Celia Duclos, Jean Paul Marie, Eric Verin
The ventilatory pattern during sequential swallowing is influenced by the vagal activity. As the vagus nerve is paired and mixed, we aimed (1) to determine if vagal implication in swallowing and breathing coordination is symmetric. (2) to study the importance of vagal afferences in swallowing and breathing coordination. Sixty two Wistar rats (7-11weeks, 260-400g) were studied by barometric plethysmography. In the first part of the study, we determined the effects of a right cervical vagotomy and the effects of a left cervical vagotomy on ventilatory pattern at rest and during sequential swallowing (14 rats with right vagotomy, 14 rats with left vagotomy and 14 rats with sham surgery)...
July 8, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28690686/vagus-nerve-stimulation-as-a-potential-adjuvant-to-behavioral-therapy-for-autism-and-other-neurodevelopmental-disorders
#8
REVIEW
Crystal T Engineer, Seth A Hays, Michael P Kilgard
BACKGROUND: Many children with autism and other neurodevelopmental disorders undergo expensive, time-consuming behavioral interventions that often yield only modest improvements. The development of adjunctive interventions that can increase the benefit of rehabilitation therapies is essential in order to improve the lives of individuals with neurodevelopmental disorders. MAIN TEXT: Vagus nerve stimulation (VNS) is an FDA approved therapy that is safe and effective in reducing seizure frequency and duration in individuals with epilepsy...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28689344/neurological-results-of-the-modified-treatment-of-epilepsy-by-stimulation-of-the-vagus-nerve
#9
Michael Vaiman, Eli Heyman, Gad Lotan
INTRODUCTION: The vagus nerve stimulation (VNS) is used for treatment of drug-resistant epilepsy but laryngeal side effects are common. We tried to improve VNS by modifying the implantation procedure. The aim was to reduce the rate of side effects that have prevented using VNS to its full capacity. METHODS: We operated on 74 pediatric patients for VNS device implantation using a modified surgical protocol incorporating lower neck incision for electrode placement and 36 patients who were operated by standard technique were used for control group...
July 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28676315/efficacy-and-long-term-tuning-parameters-of-vagus-nerve-stimulation-in-long-term-treated-depressive-patients
#10
Helge H O Müller, Caroline Lücke, Sebastian Moeller, Alexandra Philipsen, Wolfgang Sperling
Vagus nerve stimulation (VNS) is a promising neurostimulation tool for the treatment of treatment-resistant depression. Here, we report the effects of positive remission rates and tuning parameters in a group of 18 (6 female, 12 male, mean age 54) long-term treated patients. Treatment varied between 3 and 200months (mean 104.9months). Mean stimulation intensity was 1.46mA, ranging from 0.5 to 2.0mA and high-frequency stimulation of 20-25Hz (mean 23.61Hz). The remission rates in our study population clearly indicate ongoing positive effects of VNS and highlight stimulation tunings between 0...
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28673269/regulating-autonomic-nervous-system-homeostasis-improves-pulmonary-function-in-rabbits-with-acute-lung-injury
#11
Yan Liu, Tao Tao, Wenzhi Li, Yulong Bo
BACKGROUND: This study aimed to investigate the effects of regulating autonomic nervous system (ANS) homeostasis by inhibiting sympathetic hyperactivity and/or enhancing parasympathetic activity on pulmonary inflammation and functional disturbance. METHODS: An animal model of acute lung injury (ALI) was established in rabbits by an intratracheal injection of hydrochloric acid (HCl) in rabbits. Animals in control groups were received saline or HCl only, and the others received both HCl and followed treatments: vagus nerve stimulation (VNS), intravenous injection of tetrahydroaminoacridine (THA), or stellate ganglion block (SGB)...
July 3, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28666193/efficacy-of-adjunctive-vagus-nerve-stimulation-in-patients-with-dravet-syndrome-a-meta-analysis-of-68-patients
#12
REVIEW
Maxine Dibué-Adjei, Igor Fischer, Hans-Jakob Steiger, Marcel Alexander Kamp
RATIONALE: Dravet Syndrome (DS) is a severe epileptic encephalopathy of childhood involving intractable seizures, recurrent status epilepticus and cognitive decline. Because DS is a rare disease, available data is limited and evidence-based treatment guidelines are lacking. Vagus nerve stimulation (VNS) is an established neurostimulation treatment for intractable epilepsy, however little evidence is published on its efficacy in patients with DS. METHODS: We performed a meta-analysis of all peer-reviewed English language studies reporting seizure outcomes of patients with DS treated with adjunctive vagus nerve stimulation...
June 17, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28663046/long-term-vagal-stimulation-for-heart-failure-eighteen-month-results-from-the-neural-cardiac-therapy-for-heart-failure-nectar-hf-trial
#13
Gaetano M De Ferrari, Craig Stolen, Anton E Tuinenburg, D Jay Wright, Josep Brugada, Christian Butter, Helmut Klein, Petr Neuzil, Cornelis Botman, Maria Angeles Castel, Antonio D'Onofrio, Gert J de Borst, Scott Solomon, Kenneth M Stein, Bernd Schubert, Kevin Stalsberg, Nicholas Wold, Stephen Ruble, Faiez Zannad
BACKGROUND: The NECTAR-HF study evaluated safety and feasibility of vagal nerve stimulation (VNS) for the treatment of heart failure patients. The first six-month randomized phase of the study did not show improvement in left ventricular remodelling in response to VNS. This study reports the 18-month results and provides novel findings aiming to understand the lack of efficacy of VNS, including a new technique assessing the effects of VNS. METHODS: Ninety-six patients were randomized 2:1 to active or inactive VNS for 6months, thereafter VNS was activated for all patients...
June 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28658013/hippocampal-gray-volumes-increase-in-treatment-resistant-depression-responding-to-vagus-nerve-stimulation
#14
Giulia Ida Perini, Tommaso Toffanin, Giorgio Pigato, Giovanni Ferri, Halima Follador, Filippo Zonta, Carlo Pastorelli, Giulia Piazzon, Luca Denaro, Giuseppe Rolma, Mario Ermani, Domenico DʼAvella
BACKGROUND: Changes in hippocampal gray matter volumes are proposed to be involved in pathogenesis, course, and treatment response of major depressive disorder. Converging evidence suggests that reduced neurogenesis may occur in treatment-resistant depression (TRD). Vagus nerve stimulation (VNS) is a well-defined, long-term brain stimulation treatment for TRD. However, its in vivo positive effect on hippocampal modulation as mechanism of action has never been investigated before in clinical studies...
June 27, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28651170/an-analysis-of-quality-of-life-qol-in-patients-with-epilepsy-and-comorbid-psychogenic-nonepileptic-seizures-pnes-after-vagus-nerve-stimulation-vns
#15
Andrew C Vivas, Christian J Reitano, Hena Waseem, Selim R Benbadis, Fernando L Vale
PURPOSE: Patients with epilepsy (PWE) may suffer from comorbid psychogenic nonepileptic seizures (PNES). The efficacy of vagus nerve stimulation (VNS) in the treatment of epilepsy and depression is established, however the impact on PNES is unknown. Since many patients with PNES have comorbid depression, we explored the impact on quality of life (QOL) that VNS has on PWE and PNES. METHODS: The video electroencephalogram (vEEG) of all patients who underwent VNS at our institution was reviewed...
June 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28651125/online-patient-information-on-vagus-nerve-stimulation-how-reliable-is-it-for-facilitating-shared-decision-making
#16
Ronak Ved, Naomi Cobbold, Kueni Igbagiri, Mark Willis, Paul Leach, Malik Zaben
PURPOSE: This study evaluates the quality of information available on the internet for carers of children with epilepsy considering treatment with Vagus Nerve Stimulation (VNS). METHODS: Selected key phrases were entered into two popular search engines (Google™, Yahoo™). These phrases were: "Vagus nerve stimulator", alone and in combination with "childhood epilepsy", "paediatric epilepsy" and "epilepsy in childhood"; "VNS", and "VNS epilepsy". The first 50 hits per search were then screened...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28638778/synthesis-and-detonation-properties-of-5-amino-2-4-6-trinitro-1-3-dihydroxy-benzene
#17
Xingcheng Zhang, Hualin Xiong, Hongwei Yang, Guangbin Cheng
5-Amino-4,6-dinitro-1,3-dihydroxy-benzene (6) was synthesized through the ring-opening reaction of macrocyclic compound 4 with the aid of VNS (vicarious nucleophilic substitution of hydrogen) reaction conditions. The mechanism of ring opening of macrocyclic compound 4 was studied. 5-Amino-2,4,6-trinitro-1,3-dihydroxy-benzene (8) was obtained after the nitration of 6 in KNO3 and concentrated sulfuric acid. The thermal stability, sensitivity, and other detonation performances of 6 or 8 were compared to commercially used 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) or 1,3,5-trinitrotriazacyclohexane (RDX), respectively...
June 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28625397/quantitative-evaluation-of-heartbeat-interval-time-series-using-poincar%C3%A3-analysis-reveals-distinct-patterns-of-heart-rate-dynamics-during-cycles-of-vagus-nerve-stimulation-in-patients-with-heart-failure
#18
Imad Libbus, Bruce D Nearing, Badri Amurthur, Bruce H KenKnight, Richard L Verrier
BACKGROUND: Optimization of stimulation parameters is essential to maximizing therapeutic efficacy and minimizing side effects. METHODS: The ANTHEM-HF study enrolled patients with heart failure who received chronic autonomic regulation therapy (ART) with an implantable vagus nerve stimulation (VNS) system on either the right (n=30) or left side (n=29). Acute effects of continuously cycling VNS on R-R interval dynamics were evaluated using post hoc Poincaré analysis of ECG recordings collected during multiple titration sessions over an 8-12week period...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28619068/late-onset-jaw-and-teeth-pain-mimicking-trigeminal-neuralgia-associated-with-chronic-vagal-nerve-stimulation-case-series-and-review-of-the-literature
#19
Gabriela Timarova, Andrej Šteňo
BACKGROUND: Vagal nerve stimulation (VNS) for refractory epilepsy is well established. Trigeminal neuralgia itself is a common disease in adults, and thus, late-onset pain in the trigeminal region under VNS, which is extremely rare, may not be recognized as caused by VNS. CASE PRESENTATION: Two patients with drug-resistant symptomatic epilepsy treated with chronic VNS experienced stimulation-related pain in the lower and upper jaw and teeth on the side of stimulation...
June 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28615966/acute-physiological-and-electrical-accentuation-of-vagal-tone-has-no-effect-on-pain-or-gastrointestinal-motility-in-chronic-pancreatitis
#20
Jacob Juel, Christina Brock, Søren S Olesen, Adnan Madzak, Adam D Farmer, Qasim Aziz, Jens B Frøkjær, Asbjørn Mohr Drewes
BACKGROUND: The effective management of pain in chronic pancreatitis (CP) remains a therapeutic challenge. Analgesic drugs, such as opioids, and the underlying pathology can impair gut function. The autonomic nervous system influences hormone secretion and gut motility. In healthy volunteers, electrical (using noninvasive transcutaneous vagal nerve stimulation [t-VNS]) and physiological (using deep slow breathing [DSB]) modulation of parasympathetic tone results in pain attenuation and enhanced gut motility...
2017: Journal of Pain Research
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