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https://www.readbyqxmd.com/read/28625397/quantitative-evaluation-of-heartbeat-interval-time-series-using-poincar%C3%A3-analysis-reveals-distinct-patterns-of-heart-rate-dynamics-during-cycles-of-vagus-nerve-stimulation-in-patients-with-heart-failure
#1
Imad Libbus, Bruce D Nearing, Badri Amurthur, Bruce H KenKnight, Richard L Verrier
BACKGROUND: Optimization of stimulation parameters is essential to maximizing therapeutic efficacy and minimizing side effects. METHODS: The ANTHEM-HF study enrolled patients with heart failure who received chronic autonomic regulation therapy (ART) with an implantable vagus nerve stimulation (VNS) system on either the right (n=30) or left side (n=29). Acute effects of continuously cycling VNS on R-R interval dynamics were evaluated using post hoc Poincaré analysis of ECG recordings collected during multiple titration sessions over an 8-12week period...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28619068/late-onset-jaw-and-teeth-pain-mimicking-trigeminal-neuralgia-associated-with-chronic-vagal-nerve-stimulation-case-series-and-review-of-the-literature
#2
Gabriela Timarova, Andrej Šteňo
BACKGROUND: Vagal nerve stimulation (VNS) for refractory epilepsy is well established. Trigeminal neuralgia itself is a common disease in adults, and thus, late-onset pain in the trigeminal region under VNS, which is extremely rare, may not be recognized as caused by VNS. CASE PRESENTATION: Two patients with drug-resistant symptomatic epilepsy treated with chronic VNS experienced stimulation-related pain in the lower and upper jaw and teeth on the side of stimulation...
June 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28615966/acute-physiological-and-electrical-accentuation-of-vagal-tone-has-no-effect-on-pain-or-gastrointestinal-motility-in-chronic-pancreatitis
#3
Jacob Juel, Christina Brock, Søren S Olesen, Adnan Madzak, Adam D Farmer, Qasim Aziz, Jens B Frøkjær, Asbjørn Mohr Drewes
BACKGROUND: The effective management of pain in chronic pancreatitis (CP) remains a therapeutic challenge. Analgesic drugs, such as opioids, and the underlying pathology can impair gut function. The autonomic nervous system influences hormone secretion and gut motility. In healthy volunteers, electrical (using noninvasive transcutaneous vagal nerve stimulation [t-VNS]) and physiological (using deep slow breathing [DSB]) modulation of parasympathetic tone results in pain attenuation and enhanced gut motility...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28588456/activity-dependent-modulation-of-granule-cell-survival-in-the-accessory-olfactory-bulb-at-puberty
#4
Livio Oboti, Sara Trova, Roberta Schellino, Marilena Marraudino, Natalie R Harris, Olubukola M Abiona, Mojca Stampar, Weihong Lin, Paolo Peretto
The vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex, and reproductive state, yet the mechanisms underlying this variability are unclear. Here, by analyzing neuronal survival in the first processing nucleus of the VNS, namely the accessory olfactory bulb (AOB), through multiple bromodeoxyuridine birthdating protocols, we show that exposure of female mice to male soiled bedding material affects the integration of newborn granule interneurons mainly after puberty...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28585221/vagal-nerve-stimulation-for-treatment-resistant-depression
#5
REVIEW
Flavia R Carreno, Alan Frazer
Major depressive disorder (MDD) is prevalent. Although standards antidepressants are more effective than placebo, up to 35% of patients do not respond to 4 or more conventional treatments and are considered to have treatment-resistant depression (TRD). Considerable effort has been devoted to trying to find effective treatments for TRD. This review focuses on vagus nerve stimulation (VNS), approved for TRD in 2005 by the Food and Drugs Administration. Stimulation is carried by bipolar electrodes on the left cervical vagus nerve, which are attached to an implanted stimulator generator...
June 5, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28566195/parenting-stress-in-parents-of-children-with-refractory-epilepsy-before-and-after-vagus-nerve-stimulation-implantation
#6
Sung-Tse Li, Nan-Chang Chiu, Yung-Ting Kuo, Ein-Yiao Shen, Pei-Chieh Tsai, Che-Sheng Ho, Wen-Hsiang Wu, Juei-Chao Chen
OBJECTIVES: The purpose of this study was to evaluate parenting stress in parents of children with refractory epilepsy before and after their children received vagus nerve stimulation (VNS) implantation. METHODS: Parents of children with refractory epilepsy completed the Parenting Stress Index (PSI) under a psychologist's assessment before and at least 12 months after their children received VNS implantation. The PSI questionnaire measures parenting stress in two domains; a parent domain with seven subscales, and a child domain with six...
May 17, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28560798/vns-and-pregnancy-a-multicentric-experience-of-four-cases
#7
X Rodríguez-Osorio, F J López-González, Í Garamendi, J Rumià, A Matute, Á Prieto-González, M Carreño
BACKGROUND: Vagus nerve stimulation system (VNS) has been employed worldwide as adjunctive therapy in drug-resistant epileptic patients. Only nine previous pregnancies with six-positive outcomes have been reported in women with epilepsy treated with VNS since 1998. AIMS OF THE STUDY: To communicate the experience of pregnancies in women treated with VNS in our country. METHODS: Clinical data of four female patients treated with VNS during pregnancy and delivery in five gestations is described...
May 31, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28547815/balancing-the-autonomic-nervous-system-to-reduce-inflammation-in-rheumatoid-arthritis
#8
F A Koopman, M A van Maanen, M J Vervoordeldonk, P P Tak
Imbalance in the autonomic nervous system (ANS) has been observed in many established chronic autoimmune diseases, including rheumatoid arthritis (RA), which is a prototypic immune-mediated inflammatory disease (IMID). We recently discovered that autonomic dysfunction precedes and predicts arthritis development in subjects at risk of developing seropositive RA. In addition, RA patients with relatively high vagus nerve tone (higher parasympathetic parameters, measured by heart rate variability) respond better to antirheumatic therapies...
May 26, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28546285/anti-inflammatory-effects-and-mechanisms-of-vagal-nerve-stimulation-combined-with-electroacupuncture-in-a-rodent-model-of-tnbs-induced-colitis
#9
Haifeng Jin, Jie Guo, Jiemin Liu, Bin Lyu, Robert D Foreman, Jieyun Yin, Zhaohong Shi, Jiande Dz Chen
The purpose of this study was to determine effects and mechanisms of vagal nerve stimulation (VNS) and additive effects of electroacupuncture (EA) on colonic inflammation in a rodent model of IBD. Chronic inflammation in rats was induced by intrarectal TNBS (2,4,6-Trinitrobenzenesulfonic acid). The rats were then treated with sham-ES (electrical stimulation), VNS or VNS+EA for 3 weeks. Inflammatory responses were assessed by disease activity index (DAI), macroscopic scores and histological scores of colonic tissues, and plasma levels of TNF-α, IL-1β and IL-6, myeloperoxidase (MPO) activity of colonic tissues...
May 25, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28529069/cholinergic-modulation-of-the-immune-system-presents-new-approaches-for-treating-inflammation
#10
REVIEW
Donald B Hoover
The nervous system and immune system have broad and overlapping distributions in the body, and interactions of these ubiquitous systems are central to the field of neuroimmunology. Over the past two decades, there has been explosive growth in our understanding of neuroanatomical, cellular, and molecular mechanisms that mediate central modulation of immune functions through the autonomic nervous system. A major catalyst for growth in this field was the discovery that vagal nerve stimulation (VNS) caused a prominent attenuation of the systemic inflammatory response evoked by endotoxin in experimental animals...
May 18, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28522635/my-week
#11
Helen Russell
May is VN Awareness Month, which aims to highlight the valuable work VNs do in practice. Here, Helen Russell, a registered veterinary nurse and co-joint venture partner (JVP) of Vets4Pets Byfleet, describes what she did over the course of one week recently.
May 20, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28492363/vagus-nerve-stimulation-improves-working-memory-performance
#12
Lihua Sun, Jari Peräkylä, Katri Holm, Joonas Haapasalo, Kai Lehtimäki, Keith H Ogawa, Jukka Peltola, Kaisa M Hartikainen
Vagus nerve stimulation (VNS) is used for treating refractory epilepsy and major depression. While the impact of this treatment on seizures has been established, its impact on human cognition remains equivocal. The goal of this study is to elucidate the immediate effects of vagus nerve stimulation on attention, cognition, and emotional reactivity in patients with epilepsy. Twenty patients (12 male and 8 female; 45 ± 13 years old) treated with VNS due to refractory epilepsy participated in the study. Subjects performed a computer-based test of executive functions embedded with emotional distractors while their brain activity was recorded with electroencephalography...
February 19, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28491301/short-and-long-term-results-of-an-inpatient-programme-to-manage-complex-regional-pain-syndrome-in-children-and-adolescents
#13
Giovanni Cucchiaro, Kevin Craig, Kerri Marks, Kristin Cooley, Thalitha Kay Black Cox, Jennifer Schwartz
The aim of this retrospective study was to determine whether an inpatient approach and the use of regional anaesthesia techniques can accelerate the recovery to normal functions in children with Complex Regional Pain Syndrome (CRPS). This study looked at the data of patients admitted to the rehabilitation unit with a diagnosis of CRPS from January 2010 to April 2015. Variables such as hospital stay, medications administered, regional anaesthesia procedures, changes in functional status prior to treatment and at the time of discharge, psychological evaluation and diagnosis were evaluated...
May 2017: British Journal of Pain
https://www.readbyqxmd.com/read/28476920/clinically-styled-vagus-nerve-stimulation-augments-spontaneous-discharge-in-second-and-higher-order-sensory-neurons-in-rat-nucleus-of-the-solitary-tract
#14
Eric Beaumont, Regenia B Phillips Campbell, Michael C Andresen, Stephanie Lc Scofield, Krishna Singh, Imad Libbus, Bruce H KenKnight, Logan Snyder, Nathan Cantrell
Vagus nerve stimulation (VNS) currently treats patients with drug resistant epilepsy, depression and heart failure. The mild intensities used in chronic VNS suggest that primary visceral afferents and central nervous system activation are involved. Here we measured the activity of neurons in the nucleus of the solitary tract (NTS) in anesthetized rats using clinically-styled VNS. Our chief findings indicate that VNS at threshold bradycardic intensity activated NTS neuron discharge in one third of NTS neurons...
May 5, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28476589/in-vivo-stimulus-presentation-to-the-mouse-vomeronasal-system-surgery-experiment-setup-and-software
#15
Michal Yoles-Frenkel, Oksana Cohen, Rohini Bansal, Noa Horesh, Yoram Ben-Shaul
BACKGROUND: Achieving controlled stimulus delivery is a major challenge in the physiological analysis of the vomeronasal system (VNS). NEW METHOD: We provide a comprehensive description of a setup allowing controlled stimulus delivery into the vomeronasal organ (VNO) of anesthetized mice. VNO suction is achieved via electrical stimulation of the sympathetic nerve trunk (SNT) using cuff electrodes, followed by flushing of the nasal cavity. Successful application of this methodology depends on several aspects including the surgical preparation, fabrication of cuff electrodes, experimental setup modifications, and the stimulus delivery and flushing...
June 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28473243/pain-relieving-effects-of-clonazepam-and-amitriptyline-in-burning-mouth-syndrome-a-retrospective-study
#16
M Fenelon, E Quinque, E Arrive, S Catros, J C Fricain
This retrospective study aimed to evaluate the efficacy of clonazepam and amitriptyline in the treatment of burning mouth syndrome (BMS). A single-centre retrospective cohort study was performed among patients diagnosed with BMS. Either clonazepam or amitriptyline was administered. Patients were asked to evaluate their pain using a 10-point verbal numerical scale (VNS) at baseline, and at 6 weeks and 3 months of treatment. Mean pain-relief values were assessed according to the treatment received using the Kruskal-Wallis test...
May 1, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28450490/optimising-the-value-of-vns
#17
(no author information available yet)
No abstract text is available yet for this article.
April 29, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28450489/optimising-the-value-of-vns
#18
(no author information available yet)
No abstract text is available yet for this article.
April 29, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28440954/heart-rate-variability-indices-as-predictors-of-the-response-to-vagus-nerve-stimulation-in-patients-with-drug-resistant-epilepsy
#19
Hongyun Liu, Zhao Yang, Lei Huang, Wei Qu, Hongwei Hao, Luming Li
OBJECTIVE: To assess heart-rate variability (HRV) measures of interictal electrocardiography (ECG) for drug-resistant epilepsy and to relate the findings to the outcome of vagus nerve stimulation (VNS) treatment. METHODS: Time-domain, frequency-domain, and nonlinear analyses were used to analyze preoperative HRV measures in 32 patients with drug-resistant epilepsy who had received VNS implants at the same hospital and 32 healthy age- and sex-matched control subjects...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28431290/predicting-success-of-vagus-nerve-stimulation-vns-from-eeg-symmetry
#20
REVIEW
Janneke Hilderink, Marleen C Tjepkema-Cloostermans, Anita Geertsema, Janita Glastra-Zwiers, Cecile C de Vos
PURPOSE: Vagus nerve stimulation (VNS) has shown to be an effective treatment for drug resistant epilepsy, with achieving more than 50% seizure reduction in one third of the treated patients. In order to predict which patients will profit from VNS, we previously found that a low pairwise derived Brain Symmetry Index (pdBSI) could potentially predict good responders to VNS treatment. These findings however have to be validated before they can be generalized. METHODS: 39 patients (age 18-68 years) with medically intractable epilepsy who were referred for an implanted VNS system were included...
April 4, 2017: Seizure: the Journal of the British Epilepsy Association
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