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https://www.readbyqxmd.com/read/29454147/factors-associated-with-malignancy-in-hysteroscopically-resected-endometrial-polyps-a-systematic-review-and-meta-analysis
#1
Lizandra M Paravidine Sasaki, Keitty R C Andrade, Ana Claudia Morais Godoy Figueiredo, Miriam da S Wanderley, Maurício G Pereira
The objective of our study was to estimate the frequency of pre-malignant and malignant lesions in endometrial polyps and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of pre-malignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible...
February 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29453678/differential-expression-of-the-tweak-receptor-fn14-in-idh1-wild-type-and-mutant-gliomas
#2
David S Hersh, Sen Peng, Jimena G Dancy, Rebeca Galisteo, Jennifer M Eschbacher, Rudy J Castellani, Jonathan E Heath, Teklu Legesse, Anthony J Kim, Graeme F Woodworth, Nhan L Tran, Jeffrey A Winkles
The TNF receptor superfamily member Fn14 is overexpressed by many solid tumor types, including glioblastoma (GBM), the most common and lethal form of adult brain cancer. GBM is notable for a highly infiltrative growth pattern and several groups have reported that high Fn14 expression levels can increase tumor cell invasiveness. We reported previously that the mesenchymal and proneural GBM transcriptomic subtypes expressed the highest and lowest levels of Fn14 mRNA, respectively. Given the recent histopathological re-classification of human gliomas by the World Health Organization based on isocitrate dehydrogenase 1 (IDH1) gene mutation status, we extended this work by comparing Fn14 gene expression in IDH1 wild-type (WT) and mutant (R132H) gliomas and in cell lines engineered to overexpress the IDH1 R132H enzyme...
February 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29453232/a-randomized-multicenter-phase-ii-study-of-docosahexaenoic-acid-in-patients-with-a-history-of-breast-cancer-premalignant-lesions-or-benign-breast-disease
#3
Ayca Gucalp, Xi K Zhou, Elise D Cook, Judy E Garber, Katherine D Crew, Julie R Nangia, Priya Bhardwaj, Dilip D Giri, Olivier Elemento, Akanksha Verma, Hanhan Wang, J Jack Lee, Lana A Vornik, Carrie Mays, Diane Weber, Valerie Sepeda, Holly O'Kane, Margaret Krasne, Samantha Williams, Patrick G Morris, Brandy M Heckman-Stoddard, Barbara K Dunn, Clifford A Hudis, Powel H Brown, Andrew J Dannenberg
Obesity, a cause of subclinical inflammation, is a risk factor for the development of postmenopausal breast cancer (BC) and is associated with poorer cancer outcomes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, possesses anti-inflammatory properties. We hypothesized that treatment with DHA would reduce the expression of proinflammatory genes and aromatase, the rate-limiting enzyme for estrogen biosynthesis, in benign breast tissue of overweight/obese women. A randomized, placebo-controlled, double-blind phase II study of DHA given for 12 weeks to overweight/obese women with a history of stage I-III BC, DCIS/LCIS, Paget's disease, or proliferative benign breast disease was carried out...
February 16, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29452840/borrelidins-f-i-cytotoxic-and-cell-migration-inhibiting-agents-from-mangrove-derived-streptomyces-rochei-scsio-zj89
#4
Jianbin Sun, Junli Shao, Changli Sun, Yongxiang Song, Qinglian Li, Laichun Lu, Yunfeng Hu, Chun Gui, Hua Zhang, Jianhua Ju
Borrelidin A (1) is produced by several species of Streptomyces and within its bioactive scaffold, the vinylic nitrile moiety is essential for activity. We report herein newly discovered members of the borrelidin family, borrelidin F (2), borrelidin G (3), borrelidin H (4) and borrelidin I (5); all were isolated from Streptomyces rochei SCSIO ZJ89 originating from a mangrove-derived sediment sample. These structurally diverse metabolites enabled a number of new structure-activity relationships (SARs) to be identified, especially with respect to the different configurations at the C11-OH and C12-C15 double bonds for which the absolute configurations were determined using spectroscopic methods...
February 7, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29452566/near-tetraploid-cancer-cells-show-chromosome-instability-triggered-by-replication-stress-and-exhibit-enhanced-invasiveness
#5
Darawalee Wangsa, Isabel Quintanilla, Keyvan Torabi, Maria Vila-Casadesús, Amaia Ercilla, Gregory Klus, Zeynep Yuce, Claudia Galofré, Miriam Cuatrecasas, Juan José Lozano, Neus Agell, Daniela Cimini, Antoni Castells, Thomas Ried, Jordi Camps
A considerable proportion of tumors exhibit aneuploid karyotypes, likely resulting from the progressive loss of chromosomes after whole-genome duplication. Here, by using isogenic diploid and near-tetraploid (4N) single-cell-derived clones from the same parental cell lines, we aimed at exploring how polyploidization affects cellular functions and how tetraploidy generates chromosome instability. Gene expression profiling in 4N clones revealed a significant enrichment of transcripts involved in cell cycle and DNA replication...
February 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29451073/mental-health-problems-among-whistleblowers-a-comparative-study
#6
Peter G van der Velden, Mauro Pecoraro, Mijke S Houwerzijl, Erik van der Meulen
Whistleblowers play a very important and indispensable role in society and health care sector, but their act may elicit retaliation and other negative effects, which may impact their mental health. The main aim of the present comparative study is to assess to what extent whistleblowers ( N = 27) more often suffer from severe mental health problems than other population-based groups in the Netherlands, i.e., matched controls ( N = 135), cancer patients ( N = 130), persons with (partial) work disabilities ( N = 194), physically "healthy" persons ( N = 200), and general population ( N = 1026), using the 36-Item Short-Form Health Survey scales (for general mental health) and the Symptom Checklist-90-Revised scales (for specific mental health problems: depression, anxiety, agoraphobia, interpersonal sensitivity and distrust, and sleeping problems)...
January 1, 2018: Psychological Reports
https://www.readbyqxmd.com/read/29450412/clinically-approved-liposomal-nanomedicines-lessons-learned-from-the-biomolecular-corona
#7
Giulio Caracciolo
Nowadays, liposomes are the most successful drug delivery systems with a dozen drug products available in the clinic. Grafting poly-(ethylene glycol) (PEG) onto the liposome surface prevents protein binding thus prolonging blood circulation, while synthetic modification of the terminal PEG molecule with ligands (e.g. monoclonal antibodies and peptides) should promote selective accumulation in the tumor region with respect to healthy tissues. However, despite big efforts, advances have not outgrown the development stage and just a few targeted liposomal drugs are commercially available...
February 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29444662/a-systematic-approach-to-rna-associated-motif-discovery
#8
Tian Gao, Jiang Shu, Juan Cui
BACKGROUND: Sequencing-based large screening of RNA-protein and RNA-RNA interactions has enabled the mechanistic study of post-transcriptional RNA processing and sorting, including exosome-mediated RNA secretion. The downstream analysis of RNA binding sites has encouraged the investigation of novel sequence motifs, which resulted in exceptional new challenges for identifying motifs from very short sequences (e.g., small non-coding RNAs or truncated messenger RNAs), where conventional methods tend to be ineffective...
February 14, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29444281/surgical-management-of-esophageal-sarcoma-a-multicenter-european-experience
#9
D Mege, L Depypere, G Piessen, A E Slaman, B P L Wijnhoven, A Hölscher, M Nilsson, M I van Berge Henegouwen, J J B van Lanschot, W Schroeder, P A Thomas, P Nafteux, X B D'Journo
Esophageal sarcomas are rare and evidence in literature is scarce making their management difficult. The objective is to report surgical and oncological outcomes of esophageal sarcoma in a large multicenter European cohort. This is a retrospective multicenter study including all patients who underwent en-bloc esophagectomy for esophageal sarcoma in seven European tertiary referral centers between 1987 and 2016. The main outcomes and measures are pathological results, early and long-term outcomes. Among 10,936 esophageal resections for cancer, 21 (0...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29442465/polymorphism-of-gly39glu-c-116g-a-hmsh6-is-associated-with-sporadic-colorectal-cancer-development-in-the-polish-population-preliminary-results
#10
Piotr Zelga, Karolina Przybyłowska-Sygut, Marta Zelga, Adam Dziki, Ireneusz Majsterek
BACKGROUND: Colorectal cancer (CRC) remains a major source of cancer-related mortality, accounting for 10% of all cancer-related deaths. DNA mismatch repair mechanism (MMR) responsible for correcting errors generated during DNA replication and its deficiency is associated with both hereditary and sporadic CRC. Single-nucleotide polymorphisms (SNPs) are the most common forms of genetic variation, and it has been shown that the SNPs in MMR genes may modify CRC risk. OBJECTIVES: The aim of the study was to determine the relationship between gene polymorphism Glu39Gly (c...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29439836/hospital-variation-and-the-impact-of-postoperative-complications-on-the-use-of-perioperative-chemo-radio-therapy-in-resectable-gastric-cancer-results-from-the-dutch-upper-gi-cancer-audit
#11
M G Schouwenburg, L A D Busweiler, N Beck, D Henneman, S Amodio, M I van Berge Henegouwen, A Cats, R van Hillegersberg, J W van Sandick, B P L Wijnhoven, M W J Wouters, G A P Nieuwenhuijzen
BACKGROUND: Dutch national guidelines on the diagnosis and treatment of gastric cancer recommend the use of perioperative chemotherapy in patients with resectable gastric cancer. However, adjuvant chemotherapy is often not administered. The aim of this study was to evaluate hospital variation on the probability to receive adjuvant chemotherapy and to identify associated factors with special attention to postoperative complications. METHODS: All patients who received neoadjuvant chemotherapy and underwent an elective surgical resection for stage IB-IVa (M0) gastric adenocarcinoma between 2011 and 2015 were identified from a national database (Dutch Upper GI Cancer Audit)...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29436970/why-did-i-get-cancer-perceptions-of-childhood-cancer-survivors-in-korea
#12
Jaehee Yi, Min Ah Kim, Bridget G Parsons, Yelena P Wu
This study explored whether and how childhood cancer survivors in Korea ask and resolve the question of what may have caused their cancer. Thirty-one childhood cancer survivors participated in in-depth interviews about their self-questioning process in this regard. The findings indicate that Korean childhood cancer survivors pondered this question alone due to the stigma attached to cancer in the family and society. Their answers included internal factors (doing "bad things," having unhealthy eating habits, engaging in magical thinking, having a stress-prone personality, or having a biological susceptibility) or external factors (stressors, random events, the environment, or medical conditions)...
February 13, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29436037/parental-use-of-sun-protection-for-their-children-does-skin-color-matter
#13
Marcus G Tan, Shudeshna Nag, Miriam Weinstein
BACKGROUND/OBJECTIVES: Excessive sun exposure during childhood is a risk factor for skin cancer. This study aimed to compare the frequency of ideal sun protection use between parents with lighter- and darker-skinned children and explore their attitudes and beliefs on sun safety and their choice of sun protection. METHODS: Parents of children aged 6 months to 6 years completed self-administered questionnaires about sun protection practices for their children. Parents assessed their child's Fitzpatrick phototype and were divided into lighter- (Fitzpatrick phototype I-III) and darker-skinned (Fitzpatrick phototype IV-VI) groups...
February 13, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29435268/common-mental-disorders-and-association-with-telomere-length
#14
E Vakonaki, K Tsiminikaki, S Plaitis, P Fragkiadaki, D Tsoukalas, I Katsikantami, G Vaki, M N Tzatzarakis, D A Spandidos, A M Tsatsakis
Telomeres are repeated 5'-TTAGGG-3' sequences at the end of chromosomes, which maintain genomic stability. Their length is related to a number of diseases that affect humans. Apart from cancer, cardiovascular diseases, diabetes and other, telomere length has been associated with chronic diseases. Chronic mental illness includes various types of mental disorders with the most common being depression, schizophrenia and stress-anxiety. The aim of this review is to summarize the current state of knowledge on the role of telomeres in these disorders and to compare telomere length variations in patients receiving medication and patients not taking treatment...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29435174/characterization-of-cdk-5-inhibitor-20-223-aka-cp668863-for-colorectal-cancer-therapy
#15
Caroline M Robb, Smit Kour, Jacob I Contreras, Ekta Agarwal, Carter J Barger, Sandeep Rana, Yogesh Sonawane, Beth K Neilsen, Margaret Taylor, Smitha Kizhake, Rhishikesh N Thakare, Sanjib Chowdhury, Jing Wang, Jennifer D Black, Michael A Hollingsworth, Michael G Brattain, Amarnath Natarajan
Colorectal cancer (CRC) remains one of the leading causes of cancer related deaths in the United States. Currently, there are limited therapeutic options for patients suffering from CRC, none of which focus on the cell signaling mechanisms controlled by the popular kinase family, cyclin dependent kinases (CDKs). Here we evaluate a Pfizer developed compound, CP668863, that inhibits cyclin-dependent kinase 5 (CDK5) in neurodegenerative disorders. CDK5 has been implicated in a number of cancers, most recently as an oncogene in colorectal cancers...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434027/genome-sequencing-identifies-somatic-braf-duplication-c-1794_1796duptac-p-thr599dup-in-pediatric-patient-with-low-grade-ganglioglioma
#16
Katherine E Miller, Benjamin Kelly, James Fitch, Nicole Ross, Matthew R Avenarius, Elizabeth Varga, Daniel C Koboldt, Daniel R Boue, Vincent Magrini, Scott L Coven, Jonathan L Finlay, Catherine E Cottrell, Peter White, Julie M Gastier-Foster, Richard K Wilson, Jeffrey Leonard, Elaine R Mardis
Gangliogliomas [WHO grade I] are rare tumors affecting the central nervous system and are most frequently observed in children. Genome sequencing of tumors is being utilized at an increasing rate in both research and clinical settings to characterize the genetic factors that drive tumorigenesis. Here, we report a rare BRAF somatic mutation (NM_004333.4:c.1794_1796dupTAC; p.Thr599dup) in the tumor genome from a pediatric patient in her late teens, who was initially diagnosed with low-grade ganglioglioma at age 13...
February 6, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29433891/survival-after-radiation-for-stage-i-and-ii-non-small-cell-lung-cancer-with-positive-margins
#17
Brian C Gulack, Morgan L Cox, Chi-Fu Jeffrey Yang, Paul J Speicher, H Volkan Kara, Thomas A D'Amico, Mark F Berry, Matthew G Hartwig
BACKGROUND: There is limited data guiding treatment for positive margins following lobectomy for early-stage non-small cell lung cancer (NSCLC). Using data from the National Cancer Data Base, we sought to determine whether radiation therapy following lobectomy for stage I or II NSCLC was associated with improved overall survival in patients with positive margins. METHODS: Patients who underwent lobectomy without induction therapy for stage I or II NSCLC (1998-2006) with positive resection margins were selected...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433547/finite-size-effects-in-transcript-sequencing-count-distribution-its-power-law-correction-necessarily-precedes-downstream-normalization-and-comparative-analysis
#18
Wing-Cheong Wong, Hong-Kiat Ng, Erwin Tantoso, Richie Soong, Frank Eisenhaber
BACKGROUND: Though earlier works on modelling transcript abundance from vertebrates to lower eukaroytes have specifically singled out the Zip's law, the observed distributions often deviate from a single power-law slope. In hindsight, while power-laws of critical phenomena are derived asymptotically under the conditions of infinite observations, real world observations are finite where the finite-size effects will set in to force a power-law distribution into an exponential decay and consequently, manifests as a curvature (i...
February 12, 2018: Biology Direct
https://www.readbyqxmd.com/read/29433312/human-telomeric-g-quadruplex-selective-fluoro-isoquinolines-induce-apoptosis-in-cancer-cells
#19
Subhadip Maiti, Puja Saha, Tania Das, Irene Bessi, Harald Schwalbe, Jyotirmayee Dash
Small molecules that stabilize G-quadruplex structures in telomeres can prevent telomere lengthening by telomerase and subsequently lead to cell death. We herein report two fluoro-isoquinoline derivatives IQ1 and IQ2 as selective ligands for human telomeric G-quadruplex DNA. IQ1 and IQ2 containing different triazolyl side chains have been synthesized by Cu (I) catalyzed azide-alkyne cycloaddition. Fluorescence Resonance Energy Transfer (FRET) melting assay and fluorescence binding titrations indicate that both these ligands exhibit binding preference for telomeric G-quadruplex DNA (h-TELO) over other promoter DNA quadruplexes and duplex DNA...
February 13, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29432644/a-randomized-multi-national-non-inferiority-phase-iii-trial-to-evaluate-the-safety-and-efficacy-of-bf-200-ala-gel-versus-mal-cream-in-the-treatment-of-non-aggressive-basal-cell-carcinoma-with-photodynamic-therapy-pdt
#20
C A Morton, R Dominicus, P Radny, T Dirschka, A Hauschild, U Reinhold, R Aschoff, M Ulrich, S Keohane, S Ekanayake-Bohlig, S Ibbotson, R Ostendorf, C Berking, D Gröne, H J Schulze, H M Ockenfels, V Jasnoch, H Kurzen, M Sebastian, H Stege, P Staubach-Renz, G Gupta, F Hübinger, I Ziabreva, B Schmitz, A Gertzmann, H Lübbert, R-M Szeimies
BACKGROUND: Basal cell carcinoma (BCC) represents the most common non-melanoma skin cancer worldwide affecting mainly adult, fair-skinned individuals. The WHO distinguishes aggressive and non-aggressive forms of which prototypical variants of the latter are primary nodular and superficial BCC. OBJECTIVES: To demonstrate non-inferiority of BF-200 ALA (a nanoemulsion gel containing 5-aminolaevulinic acid) compared to MAL (a cream containing methyl-aminolevulinate) in the treatment of non-aggressive BCC with photodynamic therapy (PDT)...
February 12, 2018: British Journal of Dermatology
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