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Colorecal cancer

Paramita Mandal
Cells are continuously threatened by the damage caused by reactive oxygen/nitrogen species (ROS/RNS), which are produced during physiological oxygen metabolism. In our review, we will summarize the latest reports on the role of oxidative stress and oxidative stress-induced signaling pathways in the etiology of colorectal cancer. The differences in ROS generation may influence the levels of oxidized proteins, lipids, and DNA damage, thus contributing to the higher susceptibility of colon. Reactive species (RS) of various types are formed and are powerful oxidizing agents, capable of damaging DNA and other biomolecules...
June 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
R Němeček, M Svoboda, O Slabý
BACKGROUND: The combination of modern systemic chemotherapy and anti-EGFR monoclonal antibodies improves overall survival and quality of life for patients with metastatic colorecal cancer. By contrast, the addition of anti-EGFR therapy to the treatment regime of resistant patients may lead to worse progression-free survival and overall survival. Therefore, identifying sensitive and resistant patients prior to targeted therapy of metastatic colorecal cancer is a key point during the initial decision making process...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
H W Clouston, A Davenport, H Gregson, H Shaker, S Duff, C C Kirwan
INTRODUCTION: Colorectal cancer expression of Tissue Factor (TF), PAR1 and PAR2 is associated with a poor prognosis. Their stromal, rather than epithelial, expression has prognostic significance in other cancers, this has not been explored in colorectal cancer. AIM: We aimed to determine the expression patterns of Tissue Factor (TF), PAR1 and PAR2 and thrombin in colorectal cancer and normal tissue. MATERIALS AND METHODS: Cancer and distant normal tissue were sampled from 37 patients...
April 2016: Thrombosis Research
A P Davydov-Sinitsyn, O V Bazhenova, M A Liskovykh, S V Ponomartsev, I V Rykov, S A Koshkin, R V Orlova, A N Tomilin, E N Tolkunova
Previously we've described the obtainment of a subpopulation of cancer stem cells from a human colorec- tal carcinoma cell line MIP101. These cells possess elevated clonogenic and tumorigenic capacities. According to our data, depletion of stem compartment in a cancer cell population blocks its tumorigenicity. The current work is dedicated to the comparison of tumorigenic potential between cell populations with enriched or depleted stem compartment. We show that tumor growth following xenografting of enriched stem cell population can be suppressed by intramuscular injections of ganciclovir...
2015: Tsitologiia
Ming-yan Cai, Yun-shi Zhong, Ping-hong Zhou, Mei-dong Xu, Li-qing Yao
OBJECTIVE: To investigate the feasibility and safety of endoscopic full-thickness resection(EFTR) in the treatment of colorectal submucosal tumor(SMT). METHODS: From September 2009 to March 2012, 4 cases with colorectal SMT received EFTR at the Endoscopic Center in the Zhongshan Hospital of Fudan University. The operative time, complications, and follow-up data were analyzed. RESULTS: There were 3 females and 1 male. The age ranged from 33 to 78 years...
July 2012: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Beatriz Sicilia, Raquel Vicente, Fernando Gomollón
Incidence and prevalence of inflammatory bowel diseases (IBD) have shown a dramatic increase in last decades. Diagnosis can be made at any age, no sex predominance is apparent, and while mortality rates are similar to in general population, higher rates of colorec-tal cancer are evident in most studies, probably as a consequence of long-term chronic inflammation. Probably, IBD are polygenic diseases sharing genes of sus-ceptibility for both of them (Ulcerative colitis and Crohn disease), but with other specific different genes for each one...
June 2009: Acta Gastroenterologica Latinoamericana
Miao-Yun Long, Hong-Hao Li, Jun-Yao Xu, Dong-Min Lai, Zhen-Hong Weng
BACKGROUND & OBJECTIVE: Liver metastasis is the most common cause of death due to colorectal cancer. Above 50% colorecal cancer patients have liver metastasis. This study was to investigate the effect of transfection of arresten gene on liver metastasis from human colorectal cancer (LoVo) xenografts in nude mice. METHODS: The eukaryotic expression plasmid pSecTag2-arresten was transfected into human colorectal cancer cell line LoVo using Lipofectamine 2000. Cells were divided into pSecTag2-arresten group, pSecTag2 group and control group...
October 2008: Ai Zheng, Aizheng, Chinese Journal of Cancer
Xiangjian Luo, Yangde Zhang, Jianguo Li, Jian Peng, Xing Cao
The researches reported in this article are focused on the autofluorescent signal collection of colorectal tissues by laser induced autofluorescent diagnostic system, and on the signal processing by power spectra and networks methods, Pretty good clinical diagnostic sensitivity and specificity are acquired. These may serve as a foundation on which to develop a system for diagnosis of colorecal cancer.
December 2005: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
B Paule, N Brion
UNLABELLED: NEED FOR NEW CHEMOTHERAPEUTIC AGENTS: The use of 5-FU in combination with leucoverin (LV) in the treatment of advanced colorectal cancer has consistently provided antitumoral response. The antitumoral activity of the 5-FU/LV combination is associated with inhibition of thymidylate synthetase, an essential enzyme in pyrimidine de novo biosynthesis of thymidilates as precursors of DNA synthesis. However, dose-limiting toxicities and the limited impact on survival point to the need to develop new drugs and approaches to improve therapeutic efficacy and survival...
May 27, 2000: La Presse Médicale
T Lancaster, C Silagy
There has been much recent interest in the hypothesis that aspirin and other non-steroidal anti-inflammatory agents (NSAIDs) protect against gastrointestinal, particularly colorectal, carcinoma. Three lines of evidence support this hypothesis: First, NSAIDs inhibit the growth of colorecal neoplasms in laboratory rodents. Epidemiological studies in humans also suggest a protective effect. Three case control and two cohort studies have examined the relation between aspirin use and large bowel neoplasia, and four of these five studies found a risk reduction for either incidence or mortality of about 50% in regular users of aspirin...
May 1994: Digestive Diseases
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