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https://www.readbyqxmd.com/read/29036796/intestinal-ischemia-reperfusion-leads-to-early-systemic-micro-rheological-and-multiorgan-microcirculatory-alterations-in-the-rat
#1
Anita Mester, Zsuzsanna Magyar, Viktoria Sogor, Bence Tanczos, Yoav Stark, Konstantin Cherniavsky, Laszlo Bidiga, Katalin Peto, Norbert Nemeth
BACKGROUND: Intestinal ischemia-reperfusion (I/R) is a potentially life-threatening situation and its pathomechanism is not fully understood yet. OBJECTIVE: To investigate the early micro-rheological, microcirculatory and morphological consequences of intestinal I/R in a rat model. METHODS: CD rats were anesthetized and subjected to Control (n = 7) or I/R (n = 7) groups. Left femoral artery cannulation and median laparotomy were performed...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29019033/polyethyleneimine-and-chitosan-polymer-based-mucoadhesive-liquid-crystalline-systems-intended-for-buccal-drug-delivery
#2
Giovana Maria Fioramonti Calixto, Francesca Damiani Victorelli, Lívia Nordi Dovigo, Marlus Chorilli
The buccal mucosa is accessible, shows rapid repair, has an excellent blood supply, and shows the absence of the first-pass effect, which makes it a very attractive drug delivery route. However, this route has limitations, mainly due to the continuous secretion of saliva (0.5 to 2 L/day), which may lead to dilution, possible ingestion, and unintentional removal of the active drug. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can increase drug permeation through the mucosa and thereby improve drug delivery...
October 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28989072/pentoxifylline-treatment-enhances-antihypertensive-activity-of-captopril-through-hemorheological-improvement-in-spontaneously-hypertensive-rats-during-development-of-arterial-hypertension
#3
Mark B Plotnikov, Alexander Y Shamanaev, Oleg I Aliev, Anastasia V Sidekhmenova, Anna M Anishchenko, Alexander M Arkhipov
The rheological properties of blood play a significant role in the onset and progression of arterial hypertension. The aim of our work was to evaluate the effect of the angiotensin-converting enzyme inhibitor captopril (20 mg/kg/d), pentoxifylline (PTX; 100 mg/kg/d), and the combination of captopril + PTX (20 + 100 mg/kg/d) on the hemodynamic and hemorheological parameters in spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. In the group of animals that received captopril, the mean arterial pressure (MAP) was significantly lower by 30% due to a decrease in cardiac output of 23% and in total peripheral resistance (TPR) of 26% compared with the control group, whereas blood viscosity did not change significantly...
September 27, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28987016/sensitivity-of-aspiration-as-a-safety-test-before-injection-of-soft-tissue-fillers
#4
Jani Aj Van Loghem, James J Fouché, Job Thuis
BACKGROUND: Embolism due to accidental intra-arterial injection of a soft tissue filler (STF) can lead to serious complications. Physicians practice aspiration as a safety test before injection to rule out intra-arterial placement of the needle tip. The value of aspiration as a safety test is evaluated in this study, which also considered the rheological properties of different STFs and their needle dimensions. METHODS: Aspiration with eleven different needle sizes and 24 different STFs was performed using Ringer's lactate (RL) colored with blue skin marking ink and secondly an empty saline bag containing anticoagulated blood, both pressurized to 150 mm Hg to mimic arterial blood pressure...
October 7, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28983856/effect-of-hhh-therapy-on-regional-cbf-after-severe-subarachnoid-hemorrhage-studied-by-bedside-xenon-enhanced-ct
#5
Henrik Engquist, Elham Rostami, Elisabeth Ronne-Engström, Pelle Nilsson, Anders Lewén, Per Enblad
BACKGROUND: Management of delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) is difficult and still carries controversies. In this study, the effect of therapeutic hypervolemia, hemodilution, and hypertension (HHH-therapy) on cerebral blood flow (CBF) was assessed by xenon-enhanced computerized tomography (XeCT) hypothesizing an increase in CBF in poorly perfused regions. METHODS: Bedside XeCT measurements of regional CBF in mechanically ventilated SAH patients were routinely scheduled for day 0-3, 4-7, and 8-12...
October 5, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28966701/in-vitro-particulate-analogue-fluids-for-experimental-studies-of-rheological-and-hemorheological-behavior-of-glucose-rich-rbc-suspensions
#6
Diana Pinho, Laura Campo-Deaño, Rui Lima, Fernando T Pinho
Suspensions of healthy and pathological red blood cells (RBC) flowing in microfluidic devices are frequently used to perform in vitro blood experiments for a better understanding of human microcirculation hemodynamic phenomena. This work reports the development of particulate viscoelastic analogue fluids able to mimic the rheological and hemorheological behavior of pathological RBC suspensions flowing in microfluidic systems. The pathological RBCs were obtained by an incubation of healthy RBCs at a high concentration of glucose, representing the pathological stage of hyperglycaemia in diabetic complications, and analyses of their deformability and aggregation were carried out...
September 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28952169/low-molecular-weight-supramolecular-gels-under-shear-rheology-as-the-tool-for-elucidating-structure-function-correlation
#7
Arnab Dawn, Harshita Kumari
Self-healing low molecular weight supramolecular gels SMGs) represent an emerging class of smart materials, which can closely mimic the complex biological healing process, such as, blood clotting, bone repair or wound healing. However, a lack of understanding of the structure-function correlation in the selfassembly process, limits their molecular design and subsequent property tuning. Indispensability of rheological study on supramolecular gels lies in direct transcription of the assembly property to the viscoelastic behavior of the material...
September 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28946596/comparison-of-physical-parameter-measurements-between-peripheral-and-portal-blood-samples-in-patients-with-portal-hypertension
#8
Lei Zheng, Longci Sun, Qing Xu, Hong Zhou, Lei Gu, Chunhui Jiang, Chihao Zhang, Yiming Zhu, Jiayun Lin, Meng Luo
BACKGROUND: Measuring portal venous pressure is necessary to examine, diagnose, and treat portal hypertension, but current methods are invasive. OBJECTIVE: This study aimed to determine whether a noninvasive peripheral blood measurement could be used to estimate portal venous pressure by investigating correlations between certain physical parameter measurements in the peripheral blood with those obtained in portal blood samples. METHODS: A total of 128 peripheral and portal blood samples from patients (n= 128) were analyzed for blood rheology and routine blood parameters...
September 15, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28919372/biological-applications-of-kinetics-of-wetting-and-spreading
#9
REVIEW
G Ahmed, O Arjmandi Tash, J Cook, A Trybala, V Starov
Wetting and spreading kinetics of biological fluids has gained a substantial interest recently. The importance of these fluids in our lives has driven the pace of publications. Globally scientists have ever growing interest in understanding wetting phenomena due to its vast applications in biological fluids. It is impractical to review extremely large number of publications in the field of kinetics of complex biological fluids and cosmetic solutions on diverse surfaces. Therefore, biological and cosmetic applications of wetting and spreading dynamics are considered in the following areas: (i) Spreading of Newtonian liquids in the case of non-porous and porous substrates...
August 18, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28919343/characterizing-pathology-in-erythrocytes-using-morphological-and-biophysical-membrane-properties-relation-to-impaired-hemorheology-and-cardiovascular-function-in-rheumatoid-arthritis
#10
Oore-Ofe O Olumuyiwa-Akeredolu, Prashilla Soma, Antoinette V Buys, Legesse Kassa Debusho, Etheresia Pretorius
The inflammatory burden of the complex rheumatoid arthritis (RA) disease affects several organ-systems, including rheological properties of blood and its formed elements. Red blood cells (RBCs) are constantly exposed to circulating dysregulated inflammatory molecules that are co-transported within the vasculature; and their membranes may be particularly vulnerable to the accompanying oxidative stress. In the current study, we investigate biophysical and ultrastructural characteristics of RBCs obtained from a cohort of patients using atomic force microscopy (AFM), scanning electron microscopy (SEM) and confocal microscopy (CM)...
September 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28919014/regulation-and-function-of-endothelial-glycocalyx-layer-in-vascular-diseases
#11
REVIEW
Irina Sieve, Anja K Münster-Kühnel, Denise Hilfiker-Kleiner
In the vascular system, the endothelial surface layer (ESL) as the inner surface of blood vessels affects mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. It creates barriers between endothelial cells and blood and neighbouring cells. The glycocalyx, composed of glycoconjugates and proteoglycans, is an integral component of the ESL and a key element in inter- and intracellular communication and tissue homeostasis. In pathophysiological conditions (atherosclerosis, infection, ischemia/reperfusion injury, diabetes, trauma and acute lung injury) glycocalyx-degrading factors, i...
September 12, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28910078/bifacial-biomimetic-freestanding-anisotropic-catechol-interfaces-with-asymmetrically-layered-films-as-versatile-extracellular-matrix-substitutes
#12
Byung Gee Im, Minjae Do, Yoojin Kim, Mira Cho, Jae-Hyung Jang
Biological naïve extracellular matrices (ECMs) exhibit anisotropic functions in their physical, chemical, and morphological properties. Representative examples include anisotropic skin layers or blood vessels simultaneously facing multiphasic environments. Here, anisotropically multifunctional structures called BiFACIAL (biomimetic freestanding anisotropic catechol-interfaces with asymmetrically layered) films were developed simply by contacting two polysaccharide solutions of heparin-catechol (Hep-C) and chitosan-catechol (Chi-C)...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28889793/hemorheological-dysfunction-in-cardiac-syndrome-x
#13
Emine Kilic-Toprak, Olga Yaylali, Yalin Tolga Yaylali, Yasin Ozdemir, Dogangun Yuksel, Hande Senol, Tarık Sengoz, Melek Bor-Kucukatay
BACKGROUND: Cardiac syndrome X (CSX) is often described as angina or angina-like chest pain with a normal coronary arteriogram, yet the underlying pathophysiological mechanisms have not been fully elucidated. The aim of the current study was to determine alterations in blood rheology (erythrocyte aggregation and deformability, plasma viscosity - PV) in patients with CSX. METHODS: The study comprised 26 CSX patients (55.77 ± 12.33 years) and 37 age- and sex-matched (56...
September 11, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28878199/microfluidic-based-measurement-method-of-red-blood-cell-aggregation-under-hematocrit-variations
#14
Yang Jun Kang
Red blood cell (RBC) aggregation and erythrocyte sedimentation rate (ESR) are considered to be promising biomarkers for effectively monitoring blood rheology at extremely low shear rates. In this study, a microfluidic-based measurement technique is suggested to evaluate RBC aggregation under hematocrit variations due to the continuous ESR. After the pipette tip is tightly fitted into an inlet port, a disposable suction pump is connected to the outlet port through a polyethylene tube. After dropping blood (approximately 0...
September 6, 2017: Sensors
https://www.readbyqxmd.com/read/28835607/clinical-evaluation-of-whole-blood-prothrombin-time-pt-and-international-normalized-ratio-inr-using-a-laser-speckle-rheology-sensor
#15
Markandey M Tripathi, Satoru Egawa, Alexandra G Wirth, Diane M Tshikudi, Elizabeth M Van Cott, Seemantini K Nadkarni
Prothrombin time (PT) and the associated international normalized ratio (INR) are routinely tested to assess the risk of bleeding or thrombosis and to monitor response to anticoagulant therapy in patients. To measure PT/INR, conventional coagulation testing (CCT) is performed, which is time-consuming and requires the separation of cellular components from whole blood. Here, we report on a portable and battery-operated optical sensor that can rapidly quantify PT/INR within seconds by measuring alterations in the viscoelastic properties of a drop of whole blood following activation of coagulation with thromboplastin...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821071/on-the-use-of-ion-crosslinked-nanocellulose-hydrogels-for-wound-healing-solutions-physicochemical-properties-and-application-oriented-biocompatibility-studies
#16
Alex Basu, Jonas Lindh, Eva Ålander, Maria Strømme, Natalia Ferraz
Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented biocompatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material´s potential to maintain a suitable moist environment for different type of wounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28813551/an-enhanced-spring-particle-model-for-red-blood-cell-structural-mechanics-application-to-the-stomatocyte-discocyte-echinocyte-transformation
#17
Mingzhu Chen, Fergal J Boyle
Red blood cells (RBCs) are the most abundant cellular element suspended in blood. Together with the usual biconcave-shaped RBCs, i.e., discocytes, unusual-shaped RBCs are also observed under physiological and experimental conditions, e.g., stomatocytes and echinocytes. Stomatocytes and echinocytes are formed from discocytes and in addition can revert back to being discocytes; this shape change is known as the stomatocyte-discocyte-echinocyte (SDE) transformation. To-date, limited research has been conducted on the numerical prediction of the full SDE transformation...
December 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28795978/update-on-bicuspid-aortic-valve-aortopathy
#18
Evaldas Girdauskas, Johannes Petersen
PURPOSE OF REVIEW: The appropriate treatment of bicuspid aortic valve (BAV)-associated aortopathy is still controversial. We aimed to summarize recent evidence from the literature that focused on the prediction of aortopathy progression and adverse aortic events. RECENT FINDINGS: Following the detailed description of valvulo-aortic phenotypes in BAV disease in the previous imaging studies, the most current research focused on the definition of hemodynamic markers that may affect the progression of BAV-associated aortopathy and search for blood-born biomarkers to improve the prediction of adverse aortic events...
November 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28771571/optical-sensing-of-anticoagulation-status-towards-point-of-care-coagulation-testing
#19
Diane M Tshikudi, Markandey M Tripathi, Zeinab Hajjarian, Elizabeth M Van Cott, Seemantini K Nadkarni
Anticoagulant overdose is associated with major bleeding complications. Rapid coagulation sensing may ensure safe and accurate anticoagulant dosing and reduce bleeding risk. Here, we report the novel use of Laser Speckle Rheology (LSR) for measuring anticoagulation and haemodilution status in whole blood. In the LSR approach, blood from 12 patients and 4 swine was placed in disposable cartridges and time-varying intensity fluctuations of laser speckle patterns were measured to quantify the viscoelastic modulus during clotting...
2017: PloS One
https://www.readbyqxmd.com/read/28759962/effects-of-hydroxyurea-on-blood-rheology-in-sickle-cell-anemia-a-two-years-follow-up-study
#20
Nathalie Lemonne, Berenike Möckesch, Keyne Charlot, Yohann Garnier, Xavier Waltz, Yann Lamarre, Sophie Antoine-Jonville, Maryse Etienne-Julan, Marie-Dominique Hardy-Dessources, Marc Romana, Philippe Connes
The aim of the present study was to test the effects of hydroxyurea (HU) therapy on clinical, hematological and hemorheological parameters in adult patients with sickle cell anemia (SCA). Hematological and hemorheological parameters were measured in 28 SCA patients before HU therapy (i.e., baseline) and at 6, 12 and 24 months of treatment. RBC deformability was determined by ektacytometry at 30 Pa. RBC aggregation properties were investigated by light-backscatter method. Blood viscosity was measured at 225 s-1 by a cone-plate viscometer...
July 25, 2017: Clinical Hemorheology and Microcirculation
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