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https://www.readbyqxmd.com/read/28533135/enhanced-local-disorder-in-a-clinically-elusive-von-willebrand-factor-provokes-high-affinity-platelet-clumping
#1
Alexander Tischer, Venkata R Machha, Juan P Frontroth, Maria A Brehm, Tobias Obser, Reinhard Schneppenheim, Leland Mayne, S Walter Englander, Matthew Auton
Mutation of the cysteines forming the disulfide loop of the platelet GPIbα adhesive A1 domain of von Willebrand factor causes quantitative VWF deficiencies in the blood and von Willebrand disease. We report two cases of transient severe thrombocytopenia induced by DDAVP-treatment. Cys1272Trp and Cys1458Tyr mutations identified by genetic sequencing implicate an abnormal gain-of-function phenotype, evidenced by thrombocytopenia, that quickly relapses back to normal platelet counts and deficient plasma VWF. Using surface plasmon resonance, analytical rheology, and hydrogen-deuterium exchange mass spectrometry (HXMS), we decipher mechanisms of A1-GPIbα mediated platelet adhesion and resolve dynamic secondary structure elements that regulate the binding pathway...
May 19, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28532176/synthesis-of-n-alkylated-chitosan-and-its-interactions-with-blood
#2
Yuchen Huang, Yi Zhang, Longbao Feng, Liumin He, Rui Guo, Wei Xue
When hydrophobically modified chitosan (HM-CHI) comes into contact with red blood cells (RBCs), it can cause agglomeration. This property leads HM-CHI to be a potential agent to form a rapid haemostatic plug to stop bleeding at wound sites. In this study, we investigated the properties of the HM-CHI biopolymer to act as an agent that rapidly clots blood. We have examined the synthesis and structural characteristics of HM-CHI - blood substances using X-ray diffraction, infrared spectroscopy and elemental analysis...
May 22, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28529037/diabetes-development-increased-concentrations-of-the-conjugated-bile-acid-taurocholic-acid-in-serum-while-treatment-with-microencapsulated-taurocholic-acid-exerted-no-hypoglycaemic-effects
#3
Sangeetha Mathavan, Momir Mikov, Svetlana Golocorbin-Kon, Hani Al-Salami
CONTEXT: The bile acid taurocholic acid (TCA) is endogenously produced, and has shown formulation-stabilising effects when incorporated into microcapsules containing potential antidiabetic drugs. This study aimed to develop and characterise TCA-microcapsules, and test their antidiabetic effects, in an animal model of Type 1 diabetes (T1D). METHODS: Using the polymer sodium alginate (SA), SA-microcapsules (control) and TCA-microcapsules (test) were prepared, and assessed for morphology, surface composition, chemical and thermal stability, swelling, buoyancy, mechanical, release and rheological properties...
May 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28526627/dynamic-fatigue-measurement-of-human-erythrocytes-using-dielectrophoresis
#4
Yuhao Qiang, Jia Liu, E Du
Erythrocytes must undergo severe deformation to pass through narrow capillaries and submicronic splenic slits for several hundred thousand times in their normal lifespan. Studies of erythrocyte biomechanics have been mainly focused on cell deformability and rheology measured from a single application of stress and mostly under a static or quasi-static state using classical biomechanical techniques, such as optical tweezers and micropipette aspiration. Dynamic behavior of erythrocytes in response to cyclic stresses that contributes to the membrane failure in blood circulation is not fully understood...
May 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28512313/a-rapid-capillary-pressure-driven-micro-channel-to-demonstrate-newtonian-fluid-behavior-of-zebrafish-blood-at-high-shear-rates
#5
Juhyun Lee, Tzu-Chieh Chou, Dongyang Kang, Hanul Kang, Junjie Chen, Kyung In Baek, Wei Wang, Yichen Ding, Dino Di Carlo, Yu-Chong Tai, Tzung K Hsiai
Blood viscosity provides the rheological basis to elucidate shear stress underlying developmental cardiac mechanics and physiology. Zebrafish is a high throughput model for developmental biology, forward-genetics, and drug discovery. The micro-scale posed an experimental challenge to measure blood viscosity. To address this challenge, a microfluidic viscometer driven by surface tension was developed to reduce the sample volume required (3μL) for rapid (<2 min) and continuous viscosity measurement. By fitting the power-law fluid model to the travel distance of blood through the micro-channel as a function of time and channel configuration, the experimentally acquired blood viscosity was compared with a vacuum-driven capillary viscometer at high shear rates (>500 s(-1)), at which the power law exponent (n) of zebrafish blood was nearly 1 behaving as a Newtonian fluid...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28504711/the-stabilizing-effect-of-an-oligomeric-proanthocyanidin-on-red-blood-cell-membrane-structure-of-poorly-controlled-type-ii-diabetes
#6
J Visser, P J van Staden, P Soma, A V Buys, E Pretorius
Type II diabetes (T2D) is a pandemic characterized by pathological circulating inflammatory markers, high-glucose levels and oxidative stress. The hematological system is especially vulnerable to these aberrant circulating molecules, and erythrocytes (RBCs) show aberrant rheology properties, owing to the direct contact with these molecules. Pathological levels of circulating inflammatory markers in T2D therefore have a direct effect on the molecular and cellular structure of RBCs. Previous research has suggested that antioxidants may reduce oxidative stress that results from the pathological inflammatory markers...
May 15, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28503981/platelet-reactivity-influences-clot-structure-as-assessed-by-fractal-analysis-of-viscoelastic-properties
#7
Rebecca B Knowles, Matthew J Lawrence, Plinio M Ferreira, Melissa A Hayman, Lindsay A D'Silva, Sophie N Stanford, Ahmed Sabra, Arthur T Tucker, Karl M Hawkins, Phylip R Williams, Timothy D Warner, Phillip A Evans
Despite the interwoven nature of platelet activation and the coagulation system in thrombosis, few studies relate both analysis of protein and cellular parts of coagulation in the same population. In the present study, we use matched ex vivo samples to determine the influences of standard antiplatelet therapies on platelet function and use advanced rheological analyses to assess clot formation. Healthy volunteers were recruited following fully informed consent then treated for 7 days with single antiplatelet therapy of aspirin (75 mg) or prasugrel (10 mg) or with dual antiplatelet therapy (DAPT) using aspirin (75 mg) plus prasugrel (10 mg) or aspirin (75 mg) plus ticagrelor (90 mg)...
May 15, 2017: Platelets
https://www.readbyqxmd.com/read/28501920/a-dramatic-blood-plasticity-in-hibernating-and-14-day-hindlimb-unloading-daurian-ground-squirrels-spermophilus-dauricus
#8
Huan-Xin Hu, Fang-Ying Du, Wei-Wei Fu, Shan-Feng Jiang, Jin Cao, Shen-Hui Xu, Hui-Ping Wang, Hui Chang, Nandu Goswami, Yun-Fang Gao
We compared the effects of hibernation inactivity and 14-day hindlimb unloading in non-hibernating period on biochemical, rheological, and hematological parameters of blood in Daurian ground squirrels (Spermophilus dauricus). Twenty-four squirrels were randomly divided into four groups: control (CON), hibernation (HIB), post-hibernation (POST), and 14-day hindlimb unloading (HU). The results showed that serum enzymes (L-lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) activities decreased in HIB, POST, and HU squirrels compared with CON...
May 13, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28501709/calcium-ion-coordinated-dexamethasone-supramolecular-hydrogel-as-therapeutic-alternative-for-control-of-non-infectious-uveitis
#9
Wei Wu, Zhaoliang Zhang, Taotao Xiong, Wenguang Zhao, Rou Jiang, Hao Chen, Xingyi Li
Supramolecular hydrogel formed by the self-assembly of therapeutic agents have received considerable attention due to its high drug payload, carrier-free features. Herein, we constructed a dexamethasone sodium phosphate (Dex) supramolecular hydrogel in combination of Dex and calcium ion (Ca(2+)) and further demonstrated its therapeutic efficacy in the control of ocular inflammation. The developed supramolecular hydrogel was thoroughly characterized by rheology, TEM, FTIR and XRD. Calcium ions and Dex concentration had markedly influence on the sol-gel transition behavior of hydrogel and the proposed Dex supramolecular hydrogel displayed thixotropic property...
May 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28484954/repurposing-pentoxifylline-for-the-treatment-of-fibrosis-an-overview
#10
REVIEW
Wei Xiong Wen, Siang Yin Lee, Rafaella Siang, Rhun Yian Koh
Fibrosis is a potentially debilitating disease with high morbidity rates. It is estimated that half of all deaths that occur in the USA are attributed to fibrotic disorders. Fibrotic disorders are characterized primarily by disruption in the extracellular matrix deposition and breakdown equilibrium, leading to the accumulation of excessive amounts of extracellular matrix. Given the potentially high prevalence of fibrosis and the paucity of agents currently available for the treatment of this disease, there is an urgent need for the identification of drugs that can be utilized to treat the disease...
May 8, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28482621/effect-of-whole-body-cryotherapy-on-the-rheological-parameters-of-blood-in-older-women-with-spondyloarthrosis
#11
Aleksandra Kulis, Anna Misiorek, Jakub Marchewka, Jacek Głodzik, Aneta Teległów, Zbigniew Dąbrowski, Anna Marchewka
BACKGROUND: Cryotherapy is a physiotherapy method used to treat back pain in older persons. OBJECTIVE: This study aims to evaluate the changes in the rheological parameters of blood in older women with spondyloarthrosis, who underwent whole-body cryotherapy. METHODS: The experimental group comprised 69 older women with lumbar spondyloarthrosis, aged between 65 and 70 years. Due to the methodology of the procedure, the experimental group was randomly divided into three groups...
May 2, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28470950/microfluidic-technologies-and-approaches-for-studying-the-microcirculation
#12
Walter L Murfee, Shayn M Peirce
A challenge for basic and applied microvascular research is the lack of ex vivo experimental platforms that mimic the structural and functional complexity that is inherent to the microcirculation in living organisms. This Special Topic Issue highlights the emergence of microfluidic based approaches as tools for recapitulating physiologically-relevant network architectures and hemodynamics in order to study biochemical and biomechanical mechanisms of microvascular function and adaptation. This collection of review and original research articles showcases the value of microfluidics in bridging the gap between in vivo and in vitro model systems by demonstrating the utility of this technology for investigating microvascular dynamics spanning angiogenesis to blood cell rheology and for pre-clinical evaluation of therapeutic strategies that target the microcirculation...
May 4, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28458720/role-of-red-blood-cells-in-haemostasis-and-thrombosis
#13
Rustem I Litvinov, John W Weisel
In contrast to an obsolete notion that erythrocytes, or red blood cells (RBCs), play a passive and minor role in hemostasis and thrombosis, over the past decades there has been increasing evidence that RBCs have biologically and clinically important functions in blood clotting and its disorders. This review summarizes the main mechanisms that underlie the involvement of RBCs in hemostasis and thrombosis in vivo, such as rheological effects on blood viscosity and platelet margination, aggregation and deformability of RBCs; direct adhesion and indirect biochemical interactions with endothelial cells and platelets, etc...
February 2017: ISBT Science Series
https://www.readbyqxmd.com/read/28415274/earliest-effects-of-sudden-occlusions-on-pressure-profiles-in-selected-locations-of-the-human-systemic-arterial-system
#14
Marcin Majka, Giacomo Gadda, Angelo Taibi, Mirosław Gałązka, Piotr Zieliński
We have developed a numerical simulation method for predicting the time dependence (wave form) of pressure at any location in the systemic arterial system in humans. The method uses the matlab-Simulink environment. The input data include explicitly the geometry of the arterial tree, treated up to an arbitrary bifurcation level, and the elastic properties of arteries as well as rheological parameters of blood. Thus, the impact of anatomic details of an individual subject can be studied. The method is applied here to reveal the earliest stages of mechanical reaction of the pressure profiles to sudden local blockages (thromboses or embolisms) of selected arteries...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28386185/effect-of-total-flavonoids-of-radix-ilicis-pubescentis-on-cerebral-ischemia-reperfusion-model
#15
Xiaoli Yan, Huan Li, Ming Bai, Mingsan Miao
This paper aims to observe the effects of total flavonoids of Radix Ilicis pubescentis on mouse model of cerebral ischemia reperfusion. Mice were orally given different doses of total flavonoids of Radix Ilicis pubescentis 10 d, and were administered once daily. On the tenth day after the administration of 1 h in mice after anesthesia, we used needle to hook the bilateral common carotid artery (CCA) for 10 min, with 10 min ischemia reperfusion, 10 min ischemia. Then we restored their blood supply, copy the model of cerebral ischemia reperfusion; We then had all mice reperfused for 24 h, and then took their orbital blood samples and measured blood rheology...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28385246/impact-of-hydrothermal-and-mechanical-processing-on-dissolution-kinetics-and-rheology-of-oat-%C3%AE-glucan
#16
Myriam M-L Grundy, Janina Quint, Anne Rieder, Simon Ballance, Cécile A Dreiss, Peter J Butterworth, Peter R Ellis
Oat mixed-linkage β-glucan has been shown to lower fasting blood cholesterol concentrations due notably to an increase in digesta viscosity in the proximal gut. To exert its action, the polysaccharide has to be released from the food matrix and hydrated. The dissolution kinetics of β-glucan from three oat materials, varying in their structure, composition and degree of processing, was investigated by incubating the oats at 37°C over multiple time points (up to 72h). The samples were analysed for β-glucan content, weight-average molecular weight and rheological behaviour...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28375423/front-microrheology-of-the-non-newtonian-behaviour-of-blood-scaling-theory-of-erythrocyte-aggregation-by-aging
#17
C Trejo-Soto, E Costa-Miracle, I Rodriguez-Villarreal, J Cid, M Castro, T Alarcon, A Hernandez-Machado
We introduce a new framework to study the non-Newtonian behaviour of fluids at the microscale based on the analysis of front advancement. We apply this methodology to study the non-linear rheology of blood in microchannels. We carry out experiments in which the non-linear viscosity of blood samples is quantified at different haematocrits and ages. Under these conditions, blood exhibits a power-law dependence on the shear rate. In order to analyse our experimental data, we put forward a scaling theory which allows us to define an adhesion scaling number...
April 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28372321/effects-of-dance-therapy-on-the-selected-hematological-and-rheological-indicators-in-older-women
#18
Katarzyna Filar-Mierzwa, Anna Marchewka, Aneta Bac, Aleksandra Kulis, Zbigniew Dąbrowski, Aneta Teległów
OBJECTIVE: The aim of this study was to analyze the effects of dance therapy on selected hematological and rheological indicators in older women. METHODS: The study included 30 women (aged 71.8±7.4), and the control group comprised of 10 women of corresponding age. Women from the experimental group were subjected to a five-month dance therapy program (three 45-minute sessions per week); women from the control group were not involved in any regular physical activity...
March 30, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28325445/nonlinear-model-on-pulsatile-flow-of-blood-through-a-porous-bifurcated-arterial-stenosis-in-the-presence-of-magnetic-field-and-periodic-body-acceleration
#19
R Ponalagusamy, S Priyadharshini
BACKGROUND AND OBJECTIVE: Background and Objective: The motivation of cardiovascular modeling is to understand the haemodynamic and mechanical factors in the diagnosis and treatment of cardiovascular diseases. Several investigations have been carried out by many authors to understand the flow properties of blood in modelling blood flows in the circulatory system. In the present article, the pulsatile flow of Herschel-Bulkley fluid through a bifurcated arterial stenosis in a porous medium with magnetic field and periodic body acceleration has been investigated in view of understanding the role of rheological behaviour of blood, stenotic height, bifurcation angle, magnetic field and porosity of wall in the initiation and proliferation of cardiovascular diseases...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28314639/acute-dark-chocolate-ingestion-is-beneficial-for-hemodynamics-via-enhancement-of-erythrocyte-deformability-in-healthy-humans
#20
Jana Radosinska, Martina Horvathova, Karel Frimmel, Jana Muchova, Maria Vidosovicova, Rastislav Vazan, Iveta Bernatova
Erythrocyte deformability is an important property of erythrocytes that considerably affects blood flow and hemodynamics. The high content of polyphenols present in dark chocolate has been reported to play a protective role in functionality of erythrocytes. We hypothesized that chocolate might influence erythrocytes not only after repeated chronic intake, but also immediately after its ingestion. Thus, we determined the acute effect of dark chocolate and milk (with lower content of biologically active substances) chocolate intake on erythrocyte deformability...
March 2017: Nutrition Research
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