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https://www.readbyqxmd.com/read/29450473/elevated-blood-viscosity-and-micro-recirculation-linked-to-coronary-stent-malapposition
#1
Eric Poon, Vikas Thondapu, Umair Hayat, Peter Barlis, Chooi Yap, Po Kuo, Qisen Wang, Jiawei Ma, Shuang Zhu, Stephen Moore, Andrew Ooi
One particular complexity of coronary artery is the natural tapering of the vessel with proximal segments having larger caliber and distal tapering as the vessel get smaller. The natural tapering of a coronary artery often leads to proximal incomplete stent apposition (ISA). ISA alters coronary hemodynamics and creates pathological path to develop complications such as in-stent restenosis, and more worryingly, stent thrombosis. By employing state-of-the-art computer-aided design software, generic stent hoops were virtually deployed in an idealized tapered coronary artery with decreasing malapposition distance...
February 14, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29448354/shear-thinning-and-shear-thickening-of-a-confined-suspension-of-vesicles
#2
A Nait Ouhra, A Farutin, O Aouane, H Ez-Zahraouy, A Benyoussef, C Misbah
Widely regarded as an interesting model system for studying flow properties of blood, vesicles are closed membranes of phospholipids that mimic the cytoplasmic membranes of red blood cells. In this study we analyze the rheology of a suspension of vesicles in a confined geometry: the suspension, bound by two planar rigid walls on each side, is subject to a shear flow. Flow properties are then analyzed as a function of shear rate γ[over ̇], the concentration of the suspension ϕ, and the viscosity contrast λ=η_{in}/η_{out}, where η_{in} and η_{out} are the fluid viscosities of the inner and outer fluids, respectively...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29439117/the-pericyte-glia-interface-at-the-blood-brain-barrier
#3
REVIEW
Patrizia Giannoni, Jerome Badaut, Cyril Dargazanli, Alexis Fayd'Herbe De Maudave, Wendy Klement, Vincent Costalat, Nicola Marchi
The cerebrovasculature is a multicellular structure with varying rheological and permeability properties. The outer wall of the brain capillary endothelium is enclosed by pericytes and astrocyte end feet, anatomically assembled to guarantee barrier functions. We, here, focus on the pericyte modifications occurring in disease conditions, reviewing evidence supporting the interplay amongst pericytes, the endothelium, and glial cells in health and pathology. Deconstruction and reactivity of pericytes and glial cells around the capillary endothelium occur in response to traumatic brain injury, epilepsy, and neurodegenerative disorders, impacting vascular permeability and participating in neuroinflammation...
February 14, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29427440/investigation-of-pumping-mechanism-for-non-newtonian-blood-flow-with-ac-electrothermal-forces-in-a-microchannel-by-hybrid-boundary-element-method-and-immersed-boundary-lattice-boltzmann-method
#4
Qinlong Ren
Efficient pumping of blood flow in a microfluidic device is essential for rapid detection of bacterial bloodstream infections (BSI) using alternating current (AC) electrokinetics. Compared with AC electroosmosis (ACEO) phenomenon, the advantage of AC electrothermal (ACET) mechanism is its capability of pumping biofluids with high electrical conductivities at a relatively high AC voltage frequency. In the current work, the microfluidic pumping of non-Newtonian blood flow using ACET forces is investigated in detail by modeling its multi-physics process with hybrid boundary element method (BEM) and immersed boundary-lattice Boltzmann method (IB-LBM)...
February 10, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29417938/rheology-and-the-eye-blood-tears-and-other-humours
#5
EDITORIAL
E Stefánsson, M P Snead
No abstract text is available yet for this article.
February 2018: Eye
https://www.readbyqxmd.com/read/29408628/effect-of-pulse-rate-variation-on-blood-flow-through-axisymmetric-and-asymmetric-stenotic-artery-models
#6
Tapan Sood, Somnath Roy, Manabendra Pathak
The present work reports numerical simulations of blood flow patterns and wall shear stress (WSS) distributions in stenotic arteries, modelled as straight tubes. Inflow waveforms have been generated for different pulse rates considering constant volumetric flow during each pulsation cycle and a two-element windkessel model has been used to specify the outlet pressure. It is noticed that the non-Newtonian shear thinning rheology of blood produces more accurate and realistic predictions of the flow field as compared to the Newtonian assumption...
January 30, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29405456/a-capillary-flow-dynamics-based-sensing-modality-for-direct-environmental-pathogen-monitoring
#7
Katherine E Klug, Kelly A Reynolds, Jeong-Yeol Yoon
Toward ultra-simple and field-ready biosensors, we demonstrate a novel assay transducer mechanism based on interfacial property changes and capillary flow dynamics in antibody-conjugated submicron particle suspensions. Differential capillary flow is tunable, allowing pathogen quantification as a function of flow rate through a paper-based microfluidic device. Flow models based on interfacial and rheological properties indicate a significant relationship between the flow rate and the interfacial effects caused by target-particle aggregation...
February 5, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29399084/blood-rheology-of-angina-pectoris-patients-with-myocardial-injury-after-ischemia-reperfusion-and-its-effect-on-thromboxane-b2-levels
#8
Wenlong Wang, Xiaohui Huang, Yiyong Sun, Jinying Zhang
This study investigated the changes in the blood rheology of patients with angina pectoris and ischemia reperfusion injury and their effect on thromboxane B2 (TXB2) levels to examine their relationship. Forty patients with unstable angina pectoris who underwent elective percutaneous coronary intervention (PCI) were selected for the unstable angina group (UA group) and forty patients deemed free of coronary heart disease by coronary angiography were selected for the control group. Venous blood samples were drawn from all participants; patients in the UA group had blood drawn 1 day before and 1 day after the PCI procedure...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29396046/simultaneous-presence-of-hypercoagulation-and-increased-clot-lysis-time-due-to-il-1%C3%AE-il-6-and-il-8
#9
Janette Bester, Christina Matshailwe, Etheresia Pretorius
Circulating cytokines, and particularly the interleukin (IL)-family are known to play an important role in inflammation. These molecules circulate in the blood and therefore have a direct effect on the plasma molecules and the formed elements like the erythrocytes and platelets. Aberrant coagulation (hypercoagulation or blood clots that form too easily) and clot lyses (hypofibrinolysis, where clots do not dissolve properly, with an abnormally low rate of clot lysis time), are usually the hallmarks of many inflammatory conditions...
January 27, 2018: Cytokine
https://www.readbyqxmd.com/read/29368124/origins-of-portal-hypertension-in-nonalcoholic-fatty-liver-disease
#10
REVIEW
Gyorgy Baffy
Nonalcoholic fatty liver disease (NAFLD) advanced to cirrhosis is often complicated by clinically significant portal hypertension, which is primarily caused by increased intrahepatic vascular resistance. Liver fibrosis has been identified as a critical determinant of this process. However, there is evidence that portal venous pressure may begin to rise in the earliest stages of NAFLD when fibrosis is far less advanced or absent. The biological and clinical significance of these early changes in sinusoidal homeostasis remains unclear...
January 22, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29356101/eryptosis-and-hemorheological-responses-to-maximal-exercise-in-athletes-comparison-between-running-and-cycling
#11
Elie Nader, Nicolas Guillot, Louis Lavorel, Ivan Hancco, Romain Fort, Emeric Stauffer, Céline Renoux, Philippe Joly, Michèle Germain, Philippe Connes
We compared the effects of cycling and running exercise on hemorheological and hematological properties, as well as eryptosis markers. Seven endurance-trained subjects randomly performed a progressive and maximal exercise test on a cycle ergometer and a treadmill. Blood was sampled at rest and at the end of the exercise to analyze hematological and blood rheological parameters including hematocrit (Hct), red blood cell (RBC) deformability, aggregation and blood viscosity. Hemoglobin saturation (SpO2), blood lactate and glucose levels were also monitored...
January 21, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29355598/biological-activities-of-epicatechin-and-epicatechin-containing-foods-focus-on-cardiovascular-and-neuropsychological-health
#12
REVIEW
Iveta Bernatova
Recent studies have suggested that certain (-)-epicatechin-containing foods have a blood pressure-lowering capacity. The mechanisms underlying (-)-epicatechin action may help prevent oxidative damage and endothelial dysfunction, which have both been associated with hypertension and certain brain disorders. Moreover, (-)-epicatechin has been shown to modify metabolic profile, blood's rheological properties, and to cross the blood-brain barrier. Thus, (-)-epicatechin causes multiple actions that may provide unique synergy beneficial for cardiovascular and neuropsychological health...
January 17, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29331015/detection-of-human-disease-conditions-by-single-cell-morpho-rheological-phenotyping-of-blood
#13
Nicole Toepfner, Christoph Herold, Oliver Otto, Philipp Rosendahl, Angela Jacobi, Martin Kräter, Julia Stächele, Leonard Menschner, Maik Herbig, Laura Ciuffreda, Lisa Ranford-Cartwright, Michal Grzybek, Ünal Coskun, Elisabeth Reithuber, Genevieve Garriss, Peter Mellroth, Birgitta Henriques Normark, Nicola Tregay, Meinolf Suttorp, Martin Bornhäuser, Edwin R Chilvers, Reinhard Berner, Jochen Guck
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. What is lacking to advance initial blood diagnostics is an unbiased and quick functional assessment of blood that can narrow down the diagnosis and generate specific hypotheses. To address this need, we introduce the continuous, cell-by-cell morpho-rheological (MORE) analysis of diluted whole blood, without labeling, enrichment or separation, at rates of 1,000 cells/sec...
January 13, 2018: ELife
https://www.readbyqxmd.com/read/29328034/characteristics-of-articular-syndrome-in-systemic-vasculitis
#14
O Syniachenko, O Khaniukov, Ye Yehudina, H Taktashov, K Gashynova
The purpose of the study - investigation the separate joint lesion in systemic vasculitis, their X-ray sonographic characteristics, the correlation of the articular syndrome severity with extra-articular manifestations of the diseases, as well as aspects of the arthritis pathogenesis in this category of patients. The study included 525 patients in the ratio of the examined with Henoch-Schonlen purpura, microscopic polyangiitis, cryoglobulinemic vasculitis, polyarteritis nodosa, Takayasu's arteritis, Wegener's granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis Churg-Strauss as a 7:4:3:1:1:1:1...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29318859/-xingnao-kaiqiao-acupuncture-acupuncture-technique-for-restoring-consciousness-combined-with-hyperbaric-oxygen-in-patients-with-hypoxic-ischemic-encephalopathy-clinical-observation-and-its-influence-on-blood-rheology
#15
Sheng-Yu Zhang, Shao-Bing Liu, Hong-Wu Xie, Yi-Min Chen, Kang-Lin Liao, Yong Xiang, Dun Pan
OBJECTIVE: To observe the effect of "Xingnao Kaiqiao" acupuncture(acupuncture technique for restoring consciousness) combined with hyperbaric oxygen in patients with hypoxic ischemic encephalopathy and assess its influence on blood rheology. METHODS: Forty patients with hypoxic ischemic encephalopathy were randomly divided into treatment group and control group with 20 cases in each group. The treatment group received "Xingnao Kaiqiao" acupuncture combined with hyperbaric oxygen, and the control group received hyperbaric oxygen only...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29317580/-effect-of-high-intensity-alternating-magnetic-field-%C3%A2-on-viscosity-of-sheep-blood
#16
Pengxian Tao, Xiangyang Wu, Lingzhi Zhao, Feng Wang, Qi Xia, Yan Peng, Bingren Gao
To explore the changes of blood viscosity in high-intensity alternating magnetic field and the mechanisms.
 Methods: Five adult sheep were randomly selected and the blood samples were placed in high-intensity alternating magnetic field. Before and after exposure, the blood samples were taken and divided into 2 groups: a control group and a magnetic field group. The blood rheology and transmission electron microscopy (TEM) were performed.
 Results: Compared to the control group, the high shear viscosity of whole blood was decreased in the magnetic field group (P<0...
December 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29305878/study-of-microvascular-non-newtonian-blood-flow-modulated-by-electroosmosis
#17
Dharmendra Tripathi, Ashu Yadav, O Anwar Bég, Rakesh Kumar
An analytical study of microvascular non-Newtonian blood flow is investigated in presence of electro-osmosis phenomenon. Blood is considered as a Bingham rheological aqueous ionic solutions. An externally applied static axial electrical field is imposed on the system. The Poisson-Boltzmann equation for electric potential distribution is implemented to accommodate the electrical double layer in the microvascular. With long wavelength, lubrication and Debye-Hückel approximations, the boundary value problem is rendered non-dimensional...
January 3, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29287157/pharmacokinetic-evaluation-of-novel-midazolam-gel-formulations-following-buccal-administration-to-healthy-dogs
#18
Mohammed F Aldawsari, Vivian W Lau, Ramapuram J Babu, Robert D Arnold, Simon R Platt
OBJECTIVE To determine the physiochemical properties and pharmacokinetics of 3 midazolam gel formulations following buccal administration to dogs. ANIMALS 5 healthy adult hounds. PROCEDURES In phase 1 of a 2-phase study, 2 gel formulations were developed that contained 1% midazolam in a poloxamer 407 (P1) or hydroxypropyl methylcellulose (H1) base and underwent rheological and in vitro release analyses. Each formulation was buccally administered to 5 dogs such that 0.3 mg of midazolam/kg was delivered. Each dog also received midazolam hydrochloride (0...
January 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29284779/adsorption-rheological-properties-of-blood-serum-in-lung-cancer-patients
#19
Y V Dumanskiy, O Y Stoliarova, O V Syniachenko, M F Giulmamedova, Y A Potapov
The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. PATIENTS AND METHODS: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women...
December 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29275615/-changes-of-platelet-rheological-behavior-and-the-interventional-effects-of-ulinastatin-in-rats-with-high-voltage-electrical-burns
#20
Q F Zhang, Y Li, J K Feng, Y F Xu, L L Tu
Objective: To explore the influence of high-voltage electrical burns on the number of platelet aggregation, β-thromboglobulin (β-TG) and platelet factor 4 (PF-4) and the interventional effects of ulinastatin in rats with high-voltage electrical burns. Methods: A total of 240 Sprague-Dawley rats were divided into sham injury (SI) group, simple electrical burn (SEB) group, normal saline (NS) group, and ulinastatin (UTI) group according to the random number table, with 60 rats in each group. The electrical current was applied to the outside proximal part of left forelimb of rats and exited from the outside proximal part of right hind limb of rats...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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