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https://www.readbyqxmd.com/read/29660927/an-explanation-of-the-reversal-of-erythrocyte-echinocytosis-by-incubation-and-storage-by-serum-albumin
#1
P Wong
It is proposed that the specific reversal by serum albumin of the erythrocyte echinocytosis in an inorganic phosphate buffer saline or in a saline, either after 24 h in blood or after a storage of 6-7 weeks in SGAM or PAGGSM media, is due to a cell dehydration by a decrease of the total NaCl and KCl concentrations favoring the stomatocytogenic slow outward transport of inorganic phosphate with a hydrogen ion by band 3 anion exchanger, which was previously proposed to control the erythrocyte shape. This proposal would indicate that the opposition of the erythrocyte echinocytosis by serum albumin is not limited to binding to echinocytogenic amphiphiles, supported by the ability of the band 3-based mechanism of control of the erythrocyte shape to explain a variety of observations on the erythrocyte shape...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660926/abnormal-rheological-properties-of-red-blood-cells-as-a-potential-marker-of-gulf-war-illness-a-preliminary-study
#2
Michael J Falvo, Yang Chen, Jacquelyn C Klein, Duncan Ndirangu, Michael R Condon
BACKGROUND: Veterans with Gulf War Illness (GWI) experience chronic symptoms that include fatigue, pain, and cognitive impairment. This symptom cluster may be the consequence of impaired tissue oxygen delivery due to red blood cell (RBC) dysfunction. OBJECTIVE: The purpose of this preliminary study was to determine whether the microrheological behavior of RBCs is altered in GWI. METHODS: We recruited 17 cases of GWI (GWI+) and 10 age matched controls (GWI-), and examined RBC deformability and aggregation via ektacytometry along with measurement of complete blood counts...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660923/haemochromatosis-pathophysiology-and-the-red-blood-cell1
#3
Kieran J Richardson, Antony P McNamee, Michael J Simmonds
Haemochromatosis remains the most prevalent genetic disorder of Caucasian populations in Australia and the United States, occurring in ∼1 of 200 individuals and having a carrier frequency of 10-14%. Hereditary haemochromatosis is an autosomal recessive condition, that is phenotypically characterised by a gradual accumulation of iron, above and beyond that required for biological function. Once the binding capacity of iron carriers reaches saturation, the highly reactive free iron generates radicals that may lead to widespread cellular dysfunction...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660919/blood-rheology-as-a-mirror-of-endocrine-and-metabolic-homeostasis-in-health-and-disease1
#4
Jean-Frédéric Brun, Emmanuelle Varlet-Marie, Marlène Richou, Jacques Mercier, Eric Raynaud de Mauverger
 Rheological properties of plasma and blood cells are markedly influenced by the surrounding milieu: physicochemical factors, metabolism and hormones. Acid/base status, osmolality, lipid status, plasma protein pattern, oxidative stress induced by increased free radicals production, endothelium-derived factors such as nitric oxide (NO), achidonic acid derivatives modulate both red blood cell (RBC) and white cell mechanics. Therefore, regulatory axes involving liver, endothelium, kidney, pancreas, adrenal gland, endocrine heart, adipose tissue, pituitary gland, and surely other tissues play important roles in the regulation of blood fluidity...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660915/hemorheological-and-metabolic-consequences-of-renal-ischemia-reperfusion-and-their-modulation-by-n-n-dimethyl-tryptamine-on-a-rat-model
#5
Katalin Peto, Norbert Nemeth, Anita Mester, Zsuzsanna Magyar, Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Adam Deak, Laszlo Bidiga, Ede Frecska, Balazs Nemes
BACKGROUND: Micro-rheological relations of renal ischemia-reperfusion (I/R) have not been completely elucidated yet. Concerning anti-inflammatory agents, it is supposed that sigma-1 receptor agonist N,N-dimethyl-tryptamin (DMT) can be useful to reduce I/R injury. OBJECTIVE: To investigate the micro-rheological and metabolic parameters, and the effects of DMT in renal I/R in rats. METHODS: In anesthetized rats from median laparotomy both kidneys were exposed...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660913/gbt440-improves-red-blood-cell-deformability-and-reduces-viscosity-of-sickle-cell-blood-under-deoxygenated-conditions
#6
Kobina Dufu, Mira Patel, Donna Oksenberg, Pedro Cabrales
BACKGROUND: In sickle cell disease (SCD), polymerization of hemoglobin S (HbS) leads to the formation of rigid, non-deformable sickled RBCs. Loss of RBC deformability, sickling and irreversible membrane damage causes abnormal blood rheology, and increases viscosity which contributes to vasoocclusion and other SCD pathophysiology. GBT440 (generic name voxelotor) is a novel anti-polymerization and anti-sickling agent currently undergoing clinical evaluation for the treatment of SCD. OBJECTIVE: The purpose of this study was to determine the effects of GBT440 on deformability of sickle RBCs (SS RBCs) and the hyperviscosity of sickle cell blood (SS blood)...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29623975/injectable-self-assembled-peptide-hydrogels-for-glucose-mediated-insulin-delivery
#7
Mian Fu, Chenyu Zhang, Yuxuan Dai, Xue Li, Miaobo Pan, Wenlong Huang, Hai Qian, Liang Ge
Closed-loop glucose-responsive insulin delivery with excellent biocompatibility has the potential to improve the health and quality of life of diabetic patients. Herein, we developed an excellent glucose-responsive insulin delivery system using a pH-sensitive peptide hydrogel loaded with insulin and a glucose-specific enzyme. The designed peptide can be used as a carrier that is loaded with insulin and enzyme via a self-assembly process under physiological conditions. When hyperglycemia is encountered, the enzymatic conversion of glucose into gluconic acid leads to a decrease in the local pH, and the hydrogel is disassembled because of the strong inter- and intramolecular electrostatic repulsions between ornithine (Orn) residues; this is followed by the release of insulin...
April 6, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29618528/evolution-and-mechanics-of-mixed-phospholipid-fibrinogen-monolayers
#8
Ian Williams, Todd M Squires
All mammals depend on lung surfactant (LS) to reduce surface tension at the alveolar interface and facilitate respiration. The inactivation of LS in acute respiratory distress syndrome (ARDS) is generally accompanied by elevated levels of fibrinogen and other blood plasma proteins in the alveolar space. Motivated by the mechanical role fibrinogen may play in LS inactivation, we measure the interfacial rheology of mixed monolayers of fibrinogen and dipalmitoylphosphatidylcholine (DPPC), the main constituent of LS, and compare these to the single species monolayers...
April 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29614631/simple-chronic-transfusion-therapy-a-crucial-therapeutic-option-for-sickle-cell-disease-improves-but-does-not-normalize-blood-rheology-what-should-be-our-goals-for-transfusion-therapy
#9
Jon A Detterich
Sickle cell anemia is characterized by a mutation resulting in the formation of an abnormal beta-hemoglobin called hemoglobin S. Hemoglobin S polymerizes upon deoxygenation, causing impaired red blood cell deformability and increased blood viscosity at equivalent hematocrits. Thus, sickle cell disease is a hemorheologic disease that results in various pathologic processes involving multiple organ systems including the lungs, heart, kidneys and brain. Red blood cell mechanics and the perturbations on blood flow-endothelial interaction underlie much of the pathology found in sickle cell disease...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29614630/blood-rheological-abnormalities-in-sickle-cell-anemia
#10
Philippe Connes, Céline Renoux, Marc Romana, Manouk Abkarian, Philippe Joly, Cyril Martin, Marie-Dominique Hardy-Dessources, Samir K Ballas
This review focuses on the contribution of abnormal blood rheology in the pathophysiology of sickle cell anemia (SCA). SCA is characterized by a reduction of red blood cell (RBC) deformability but this reduction is very heterogeneous among patients. Recent works have shown that patients with the lowest RBC deformability (measured by ektacytometry) have enhanced hemolysis and would be more prone to develop several complications such as priapism, leg ulcers and glomerulopathy. In contrast, patients with the highest deformability, and not under hydroxyurea therapy, seem to develop more frequently vaso-occlusive like events...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29581738/effect-of-probucol-on-hemodynamics-rheology-and-blood-lipid-of-diabetic-retinopathy
#11
Hong Liu, Mingming Cai
The effect of probucol in the treatment of diabetic retinopathy was investigated to analyze its impact on its hemodynamics, rheology and blood lipid. A total of 80 patients with diabetic retinopathy who were treated in the Ninth People's Hospital of Chongqing (Chongqing, China) from January 2015 to August 2016 were selected and divided into two groups by random number table, with 40 patients in each group. Control group was treated by conventional and intensive glycemic control and antihypertensive therapy, while observation group was orally administered with 0...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29578415/-endothelial-dysfunction-and-microscirculation-features-in-patients-with-high-risk-of-development-of-reperfusion-syndrome-in-conditions-of-reconstruction-arterial-operations
#12
А Kolotylo, I Venher, S Kostiv, A Iftodiy
Aim - to study the state of the microcirculatory bed and the endothelial system in patients at risk of developing reperfusion syndrome and suggest methods for their correction. The work included 29 patients with obliterating diseases of the abdominal aorta and lower limb arteries with a high risk of developing reperfusion complications. Two groups of patients were identified. Group I - 8 patients, preoperative preparation include the generally accepted approaches. Group II - 21 patients whose preoperative preparation included, in addition to preparations for improving rheological blood conditions, prolonged epidural anesthesia, intravenous injection of hydroxyethylstarches, korvetin and alprostadil...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29570200/microfluidic-determination-of-lymphocyte-vascular-deformability-effects-of-intracellular-complexity-and-early-immune-activation
#13
Ning Kang, Quan Guo, Emel Islamzada, Hongshen Ma, Mark D Scott
Despite the critical importance of mechanical (rheological + extrudability) deformability in the vascular flow of lymphocytes, it has been poorly investigated due to the limitations of existing technological tools. Microfluidics analysis of leukocyte deformability offers significant advantages in that it offers high throughput, large sample population and the ability to analyze a heterogeneous population. These advantages are in stark contrast to previous approaches that focused on single cell measurements...
March 23, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29562483/effects-of-aging-and-gender-on-micro-rheology-of-blood-in-3-to-18-months-old-male-and-female-wistar-crl-wi-rats
#14
Viktoria Somogyi, Katalin Peto, Adam Deak, Bence Tanczos, Norbert Nemeth
BACKGROUND: Age- and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents. OBJECTIVE: We aimed to investigate the influence of aging and gender on hemorheological parameters in rats. METHODS: Coeval male (n=10) and female (n=10) Wistar (Crl:WI) rats were followed-up over 15 months...
March 12, 2018: Biorheology
https://www.readbyqxmd.com/read/29561062/how-viscoelastic-is-human-blood-plasma
#15
S Varchanis, Y Dimakopoulos, C Wagner, J Tsamopoulos
Blood plasma has been considered a Newtonian fluid for decades. Recent experiments (Brust et al., Phys. Rev. Lett., 2013, 110) revealed that blood plasma has a pronounced viscoelastic behavior. This claim was based on purely elastic effects observed in the collapse of a thin plasma filament and the fast flow of plasma inside a contraction-expansion microchannel. However, due to the fact that plasma is a solution with very low viscosity, conventional rotational rheometers are not able to stretch the proteins effectively and thus, provide information about the viscoelastic properties of plasma...
March 21, 2018: Soft Matter
https://www.readbyqxmd.com/read/29557743/polymeric-and-non-polymeric-injectable-in-situ-forming-implant-systems-for-sustained-delivery-of-lornoxicam-in-vitro-and-in-vivo-evaluation
#16
Soad Ali Yehia, Sally Adel Abdel Halim, Mary Yosry Aziz
OBJECTIVE: Formulation of injectable in situ forming implant (ISI) systems of lornoxicam for dental and post operative pain management to decrease dosing frequency and increase patient compliance. METHOD: Polymeric in situ implant solutions were prepared using different concentrations and inherent viscosities of Poly-DL-lactide (PDL) or DL-lactide/glycolide copolymer (PDLG) using 22X4 factorial experimental design. Non polymeric systems were prepared using different concentrations of lipids like cetyl alcohol and stearyl alcohol and also sucrose acetate isobutyrate (SAIB) using 32 factorial experimental design...
March 19, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29546060/acute-effect-of-hypervolemic-hemodilution-on-retrobulbar-hemodynamics-in-anterior-ischemic-optic-neuropathy
#17
Marion Bienert, Niklas Plange, Andreas Remky, Kay Oliver Arend, David Kuerten
Purpose: Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods: 24 patients with acute NAION were included. Retrobulbar hemodynamics were measured using color Doppler imaging before and 15 min after intravenous infusion of 250 cc 10% hydroxyethyl starch (HES)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29521199/exercise-induced-cardioprotection-via-enos-a-putative-role-of-red-blood-cell-signaling
#18
Tatsiana Suvorava, Miriam M Cortese-Krott
Moderate exercise training is a key aspect of primary and secondary prevention strategies. Shear-induced upregulation of eNOS activity and function in the vascular endothelium is considered as one of the main molecular mechanisms of exercise-induced protection against myocardial ischemia/reperfusion (I/R) injury. It has been reported that levels of plasma nitrite, which are largely dependent on eNOS activity, were increased in healthy subjects after acute exercise, while this increase was abolished in coronary artery disease (CAD) patients...
March 6, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29504527/obesity-blood-rheology-and-angiogenesis
#19
Maciej Wiewiora, Maciej Twardzik, Albert Krzak, Jerzy Piecuch
Adipose tissue is actively involved in angiogenesis through secretion of biologically active substances. This topic has been the subject of many recent publications concerning the pathophysiology and treatment of obesity. We discuss the relationship between obesity, angiogenesis and blood rheology.
February 28, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29504386/extracorporeal-shockwave-therapy-on-muscle-tissue-the-effects-on-healthy-athletes
#20
A Notarnicola, I Covelli, G Maccagnano, R Marvulli, L Mastromauro, G Ianieri, S Boodhoo, A Turitto, L Petruzzella, G Farì, F P Bianchi, S Tafuri, B Moretti
The aim of this study is to investigate the effects of extracorporeal shock wave therapy (ESWT) on muscle rheological and functional properties in a population of young athletes. Thirty-two football and basketball players were recruited and randomized into two groups. The athletes underwent three sessions of therapy administered every five days to the thigh muscles. The treatment consisted of ESWT (electromagnetic generator, Energy Flux Density=0.03 mJ/mm2) or a placebo treatment bilaterally on the quadricep and femoral bicep muscles...
January 2018: Journal of Biological Regulators and Homeostatic Agents
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