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Vagus nerve stimulation

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https://www.readbyqxmd.com/read/29907608/noninvasive-vagus-nerve-stimulation-as-acute-therapy-for-migraine-the-randomized-presto-study
#1
Cristina Tassorelli, Licia Grazzi, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Stefanie Dorlas, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti
OBJECTIVE: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled trial. METHODS: A total of 248 participants with episodic migraine with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants were to repeat treatment if pain had not improved in 15 minutes...
June 15, 2018: Neurology
https://www.readbyqxmd.com/read/29905938/evolution-over-time-of-sudep-incidence-a-nationwide-population-based-cohort-study
#2
Torbjörn Tomson, Olafur Sveinsson, Sofia Carlsson, Tomas Andersson
Prompted by a recent report on declining incidence of sudden unexpected death in epilepsy (SUDEP) following implantation of a vagus nerve stimulator (VNS), we analyzed SUDEP risk over 6 years in a population-based cohort of 60 952 epilepsy patients in Sweden. All deaths from July 1, 2006 through December 31, 2011, were identified. Those with epilepsy mentioned on the death certificate were adjudicated for SUDEP using medical records and autopsy reports. In all, 292 SUDEP cases were identified. Comparing the first years (2006-2007) with the subsequent 4 years (2008-2011), the crude and standardized (to the US 2000 population) incidence of SUDEP (whether or not possible SUDEP was included) was significantly lower during the second time period; Incidence rate ratios based on standardized rates was estimated at 0...
June 15, 2018: Epilepsia
https://www.readbyqxmd.com/read/29897267/efficacy-and-mode-of-action-of-external-trigeminal-neurostimulation-in-migraine
#3
Jean Schoenen, Gianluca Coppola
Available preventive drug treatments for migraine lack complete efficacy and often have unpleasant adverse effects. Hence their clinical utility and therapeutic adherence are limited. Hence, non-invasive neurostimulation methods applied over various peripheral sites (forehead, mastoid, upper arm, cervical vagus nerve) have raised great interest because of their excellent efficacy/tolerance profile. Amongst them external trigeminal nerve stimulation (eTNS) was first to obtain FDA approval for migraine therapy...
June 13, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29895444/tragus-or-cymba-conchae-investigating-the-anatomical-foundation-of-transcutaneous-auricular-vagus-nerve-stimulation-tavns
#4
Bashar W Badran, Joshua C Brown, Logan T Dowdle, Oliver J Mithoefer, Nicholas T LaBate, James Coatsworth, William H DeVries, Christopher W Austelle, Lisa M McTeague, Alfred Yu, Marom Bikson, Dorothea D Jenkins, Mark S George
No abstract text is available yet for this article.
June 6, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29889110/intraoperative-neural-monitoring-in-endoscopic-thyroidectomy-via-bilateral-areola-approach
#5
Daqi Zhang, Qingfeng Fu, Gianlorenzo Dionigi, Tie Wang, Jingwei Xin, Jiao Zhang, Gaofeng Xue, Hongbo Li, Hui Sun
OBJECTIVE: The aim of this report was dual: (a) to describe the step by step standardized intraoperative neural monitoring (IONM) procedure for recurrent laryngeal nerve (RLN) and external branch of the superior laryngeal nerve focusing on percutaneous IONM method, and (b) evaluation and outcomes of intermittent IONM in 237 endoscopic thyroidectomy via bilateral areolar approach cases. MATERIALS AND METHODS: A 10-mm curved incision is made along the margin of the right areola at the 2 to 4 o'clock position for the 30-degree endoscope...
June 7, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29883598/vagal-afferent-activation-suppresses-systemic-inflammation-via-the-splanchnic-anti-inflammatory-pathway
#6
Evilin Naname Komegae, David George Stephen Farmer, Virginia Leah Brooks, Michael Joseph McKinley, Robin Michael McAllen, Davide Martelli
Electrical stimulation of the vagus nerve (VNS) is a novel strategy used to treat inflammatory conditions. Therapeutic VNS activates both efferent and afferent fibers; however, the effects attributable to vagal afferent stimulation are unclear. Here, we tested if selective activation of afferent fibers in the abdominal vagus suppresses systemic inflammation. In urethane-anesthetized rats challenged with lipopolysaccharide (LPS, 60 µg/kg, i.v.), abdominal afferent VNS (2 Hz for 20 min) reduced plasma tumor necrosis factor alpha (TNF) levels 90 min later by 88% compared with unmanipulated animals...
June 5, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29870432/long-term-sustained-cognitive-benefits-of-vagus-nerve-stimulation-in-refractory-depression
#7
Véronique Desbeaumes Jodoin, François Richer, Jean-Philippe Miron, Marie-Pierre Fournier-Gosselin, Paul Lespérance
BACKGROUND: Treatment-resistant depression (TRD) is a serious chronic condition disabling patients functionally and cognitively. Chronic vagus nerve stimulation (VNS) is recognized for the management of TRD, but few studies have examined its long-term effects on cognitive dysfunction in unipolar and bipolar resistant depression. OBJECTIVE: The purpose of this study was to assess the course of cognitive functions and clinical symptoms in a cohort of patients treated with VNS for TRD...
June 4, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29844696/electroacupuncture-therapy-in-inflammation-regulation-current-perspectives
#8
REVIEW
Ji-Yeun Park, Uk Namgung
Although acupuncture therapy is increasingly used to treat diverse symptoms and disorders in humans, its underlying mechanism is not known well. Only recently have experimental studies begun to provide insights into how acupuncture stimulation generates and relates to pathophysiological responsiveness. Acupuncture intervention is frequently used to control pathologic symptoms in several visceral organs, and a growing number of studies using experimental animal models suggest that acupuncture stimulation may be involved in inducing anti-inflammatory responses...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29844694/a-review-of-vagus-nerve-stimulation-as-a-therapeutic-intervention
#9
REVIEW
Rhaya L Johnson, Christopher G Wilson
In this review, we provide an overview of the US Food and Drug Administration (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as information about the ongoing studies and preclinical research to expand the use of VNS to additional applications. VNS is currently FDA approved for therapeutic use in patients aged >12 years with drug-resistant epilepsy and depression. Recent studies of VNS in in vivo systems have shown that it has anti-inflammatory properties which has led to more preclinical research aimed at expanding VNS treatment across a wider range of inflammatory disorders...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29802915/analysis-of-peripheral-ghrelin-signaling-via-the-vagus-nerve-in-ghrelin-receptor-restored-ghsr-null-mice
#10
Tadashi Okada, T M Zaved Waise, Koji Toshinai, Yuichiro Mita, Hideyuki Sakoda, Masamitsu Nakazato
The vagus nerve connects peripheral organs to the central nervous system (CNS), and gastrointestinal hormones transmit their signals to the CNS via the vagal afferent nerve. Ghrelin, a gastric-derived orexigenic peptide, stimulates food intake by transmitting starvation signals via the vagus nerve. To understand peripheral ghrelin signaling via the vagus nerve, we investigated the ghrelin receptor (GHSR)-null mouse. For this purpose, we tried to produce mice in which GHSR was selectively expressed in the hindbrain and vagus nerve...
May 23, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29797377/vagus-nerve-stimulation-promotes-gastric-emptying-by-increasing-pyloric-opening-measured-with-magnetic-resonance-imaging
#11
K-H Lu, J Cao, S Oleson, M P Ward, R J Phillips, T L Powley, Z Liu
BACKGROUND: Vagus nerve stimulation (VNS) is an emerging electroceutical therapy for remedying gastric disorders that are poorly managed by pharmacological treatments and/or dietary changes. Such therapy seems promising as the vagovagal neurocircuitry modulates the enteric nervous system to influence gastric functions. METHODS: Here, the modulatory effects of left cervical VNS on gastric emptying in rats were quantified using a (i) feeding protocol in which the animal voluntarily consumed a postfast, gadolinium-labeled meal and (ii) a non-invasive imaging method to measure antral motility, pyloric activity and gastric emptying based on contrast-enhanced magnetic resonance imaging (MRI) and computer-assisted image processing pipelines...
May 24, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29795463/the-vagus-neurometabolic-interface-and-clinical-disease
#12
REVIEW
Emily Battinelli Masi, Sergio Iván Valdés-Ferrer, Benjamin Ethan Steinberg
The nervous system both monitors and modulates body metabolism to maintain homoeostasis. In disease states such as obesity and diabetes, the neurometabolic interface is dysfunctional and contributes to clinical illness. The vagus nerve, in particular, with both sensory and motor fibres, provides an anatomical substrate for this interface. Its sensory fibres contain receptors for important circulating metabolic mediators, including leptin and cholecystokinin, and provide real-time information about these mediators to the central nervous system...
May 24, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29791477/functional-characterization-of-oxazolone-induced-colitis-and-survival-improvement-by-vagus-nerve-stimulation
#13
Elisa Meroni, Nathalie Stakenborg, Pedro J Gomez-Pinilla, Gert De Hertogh, Gera Goverse, Gianluca Matteoli, Simon Verheijden, Guy E Boeckxstaens
BACKGROUND: Oxazolone-induced colitis has been frequently used in literature as a model of IBD, but insights into the underlying immune response and pathological features are surprisingly still very limited. Vagus nerve stimulation (VNS) has proven to be effective in innate and Th1/Th17 predominant inflammatory models, including pre-clinical models of colitis, however to what extent VNS is also effective in ameliorating Th2-driven colitis remains to be studied. In the present study, we therefore further characterized the immune response in oxazolone-induced colitis and investigated the potential therapeutic effect of VNS...
2018: PloS One
https://www.readbyqxmd.com/read/29789596/cervical-vagus-nerve-morphometry-and-vascularity-in-the-context-of-nerve-stimulation-a-cadaveric-study
#14
Niels Hammer, Sabine Löffler, Yusuf Ozgur Cakmak, Benjamin Ondruschka, Uwe Planitzer, Michael Schultz, Dirk Winkler, David Weise
Vagus nerve stimulation (VNS) has become a well-established therapy for epilepsy and depression, and is emerging to treat inflammatory disease, with the cervical vagus nerve (CVN) as major stimulation site. CVN morphometries are missing for VNS, considering its variability. Morphometric data were obtained from CVNs in 27 cadavers, including branching patterns and histology. Cross-sectional area, greater and lesser diameters averaged 7.2 ± 3.1 mm2 , 5.1 ± 1.5 and 4.1 ± 1.3 mm, and were ≤11...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29786802/-treatment-with-neurostimulation-and-ketogenic-diet-for-people-with-medically-refractory-epilepsy
#15
Eva Kumlien, Tove Hallbook, Maria Dahlin
For some people with medically refractory epilepsy adjunct treatment with neurostimulation and ketogenic diet can be an option. Vagal nerve stimulation, VNS, consists of chronic intermittent electrical stimulation of the vagus nerve. VNS is effective and well tolerated in adolescents and adults. There is insufficient evidence on the efficacy of deep brain stimulation, DBS, and brain-responsive neurostimulation, RNS. Ketogenic diet is an established treatment in epilepsy with an increased number of indications, especially in neurometabolic diseases, where dietary therapy can completely eliminate epilepsy and improve cognitive and motor development...
May 22, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29785522/non-invasive-vagus-nerve-stimulation-significantly-improves-quality-of-life-in-patients-with-persistent-postural-perceptual-dizziness
#16
Ozan E Eren, Filipp Filippopulos, Kristina Sönmez, Ken Möhwald, Andreas Straube, Florian Schöberl
Persistent postural-perceptual dizziness (PPPD) is one of the most common causes of chronic vestibular disorders, with a substantial portion of the affected patients showing no significant improvement to standard therapies (i.e., pharmacotherapy, behavioral psychotherapy). Patients with PPPD have been shown to have a significant comorbidity with anxiety disorders and depression. Further, these patients show an activation of the autonomic nervous system resulting in symptoms such as nausea, increase of heart rate, and sweating...
May 21, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29770647/neuromodulation-for-tinnitus-treatment-an-overview-of-invasive-and-non-invasive-techniques
#17
REVIEW
Nicole Peter, Tobias Kleinjung
Tinnitus is defined as a perception of sound without any external sound source. Chronic tinnitus is a frequent condition that can affect the quality of life. So far, no causal cure for tinnitus has been documented, and most pharmacologic and psychosomatic treatment modalities aim to diminish tinnitus' impact on the quality of life. Neuromodulation, a novel therapeutic modality, which aims at alternating nerve activity through a targeted delivery of a stimulus, has emerged as a potential option in tinnitus treatment...
March 12, 2018: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29759717/low-level-vagus-nerve-stimulation-suppresses-post-operative-atrial-fibrillation-and-inflammation-a-randomized-study
#18
Stavros Stavrakis, Mary Beth Humphrey, Benjamin Scherlag, Omer Iftikhar, Purvi Parwani, Mubasher Abbas, Adrian Filiberti, Christian Fleming, Yanqing Hu, Paul Garabelli, Arthur McUnu, Marvin Peyton, Sunny S Po
OBJECTIVES: This study sought to examine the efficacy of low-level vagus nerve stimulation (LLVNS) in suppressing post-operative atrial fibrillation (POAF) and inflammatory cytokines in patients undergoing cardiac surgery. BACKGROUND: POAF often complicates cardiac surgery. METHODS: Patients undergoing cardiac surgery were randomized to active or sham LLVNS. In all patients, a bipolar wire was sutured to the vagus nerve pre-ganglionic fibers alongside the lateral aspect of the superior vena cava...
September 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29744667/vagus-nerve-stimulation-exerts-cardioprotection-against-myocardial-ischemia-reperfusion-injury-predominantly-through-its-efferent-vagal-fibers
#19
Watthana Nuntaphum, Wanpitak Pongkan, Suwakon Wongjaikam, Savitree Thummasorn, Pongpan Tanajak, Juthamas Khamseekaew, Kannaporn Intachai, Siriporn C Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Vagus nerve stimulation (VNS) has been shown to exert cardioprotection against myocardial ischemia/reperfusion (I/R) injury. However, whether the cardioprotection of VNS is mainly due to direct activation through its ipsilateral efferent fibers (motor) rather than indirect effects mediated by the afferent fibers (sensory) have not been clearly understood. We hypothesized that VNS exerts cardioprotection predominantly through its efferent vagal fibers. Thirty swine (30-35 kg) were randomized into five groups: I/R no VNS (I/R), and left mid-cervical VNS with both vagal trunks intact (LC-VNS), with left vagus nerve transection (LtVNX), with right vagus nerve transection (RtVNX) and with atropine pretreatment (Atropine), respectively...
May 9, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29740975/similarities-between-the-responses-to-ant-dbs-and-prior-vns-in-refractory-epilepsy
#20
Toni Kulju, Joonas Haapasalo, Kai Lehtimäki, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: Neurostimulation has offered new treatment options in refractory epilepsy, first with vagus nerve stimulation (VNS) and more recently with deep brain stimulation (DBS). There is a lack of previous detailed data assessing the relationship between VNS and ANT-DBS. The aim of this study was to investigate the potential correlation between therapeutic responses to VNS and ANT-DBS. MATERIALS AND METHODS: A total of 11 patients with previous VNS therapy underwent ANT-DBS implantation...
May 8, 2018: Brain and Behavior
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