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https://www.readbyqxmd.com/read/29898247/batf-regulates-the-expression-of-nfil3-wnt10a-and-mir155hg-for-efficient-induction-of-antibody-class-switch-recombination-in-mice
#1
Rosemary E Morman, Patrick G Schweickert, Stephen F Konieczny, Elizabeth J Taparowsky
BATF functions in T cells and B cells to control the host response to antigen and promote the production of class switched immunoglobulins. In this study, we demonstrate that BATF expression increases rapidly, and transiently, following B cell stimulation and use an inducible murine model of BATF deletion to show that this induction is necessary, and sufficient, for immunoglobulin (Ig) class switch recombination (CSR). We examine two genes (Nfil3 and miR155gh) that are positively regulated, and one gene (Wnt10a) that is negatively regulated by BATF during CSR...
June 13, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29890546/transcriptomic-analysis-of-the-association-between-diabetes-mellitus-and-myocardial-infarction
#2
Lijuan Song, Wenjun You, Peng Wang, Feng Li, Huakun Liu
BACKGROUND: Diabetes mellitus (DM) is a major risk factor for coronary artery disease (CAD), and the complications of CAD are the leading cause of deaths among people with DM. Herein, this study aims to identify the common genes and pathways between diabetes and myocardial infarction (MI) to provide more clues for the related mechanism studies. METHODS: Differentially expressed genes (DEGs) were identified using the cutoff (|log2(fold change)|>0.45 and P value<0...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29712774/eif4e-binding-proteins-1-and-2-limit-macrophage-anti-inflammatory-responses-through-translational-repression-of-il-10-and-cyclooxygenase-2
#3
Mirtha William, Louis-Philippe Leroux, Visnu Chaparro, Julie Lorent, Tyson E Graber, Marie-Noël M'Boutchou, Tania Charpentier, Aymeric Fabié, Charles M Dozois, Simona Stäger, Léon C van Kempen, Tommy Alain, Ola Larsson, Maritza Jaramillo
Macrophages represent one of the first lines of defense during infections and are essential for resolution of inflammation following pathogen clearance. Rapid activation or suppression of protein synthesis via changes in translational efficiency allows cells of the immune system, including macrophages, to quickly respond to external triggers or cues without de novo mRNA synthesis. The translational repressors eIF4E-binding proteins 4E-BP1 and 4E-BP2 (4E-BP1/2) are central regulators of proinflammatory cytokine synthesis during viral and parasitic infections...
April 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29659895/identification-of-differential-transcriptional-patterns-in-primary-and-secondary-hyperparathyroidism
#4
Samira Mercedes Sadowski, Marc Pusztaszeri, Marie-Claude Brulhart-Meynet, Volodymyr Petrenko, Claudio De Vito, Jonathan Sobel, Céline Delucinge-Vivier, Electron Kebebew, Romano Regazzi, Jacques Philippe, Frédéric Triponez, Charna Dibner
Context: Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion; however, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PGs) in sporadic primary (HPT1) and secondary hyperparathyroidism (HPT2). Objective: To evaluate dynamic alterations in molecular patterns as a function of the type of PG pathology, a comparative transcript analysis was conducted in subgroups of healthy samples, sporadic HPT1 adenoma and hyperplasia, and HPT2...
June 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29467226/e4bp4-nfil3-modulates-the-epigenetically-repressed-ras-effector-rassf8-function-through-histone-methyltransferases
#5
Isai Pratha Karthik, Pavitra Desai, Sudarkodi Sukumar, Aleksandra Dimitrijevic, Krishnaraj Rajalingam, Sundarasamy Mahalingam
RAS proteins are major human oncogenes, and most of the studies are focused on enzymatic RAS effectors. Recently, nonenzymatic RAS effectors (RASSF, RAS association domain family) have garnered special attention because of their tumor-suppressive properties in contrast to the oncogenic potential of the classical enzymatic RAS effectors. Whereas most members of RASSF family are deregulated by promoter hypermethylation, RASSF8 promoter remains unmethylated in many cancers but the mechanism(s) of its down-regulation remains unknown...
April 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29311361/multiple-levels-of-control-determine-how-e4bp4-nfil3-regulates-nk-cell-development
#6
Tomasz Kostrzewski, Aaron J Borg, Yiran Meng, Iva Filipovic, Victoria Male, Andreas Wack, Peter A DiMaggio, Hugh J M Brady
The transcription factor E4bp4/Nfil3 has been shown to have a critical role in the development of all innate lymphoid cell types including NK cells. In this study, we show that posttranslational modifications of E4bp4 by either SUMOylation or phosphorylation have profound effects on both E4bp4 function and NK cell development. We examined the activity of E4bp4 mutants lacking posttranslational modifications and found that Notch1 was a novel E4bp4 target gene. We observed that abrogation of Notch signaling impeded NK cell production and the total lack of NK cell development from E4bp4 -/- progenitors was completely rescued by short exposure to Notch peptide ligands...
February 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29262349/natural-killer-cells-promote-fetal-development-through-the-secretion-of-growth-promoting-factors
#7
Binqing Fu, Yonggang Zhou, Xiang Ni, Xianhong Tong, Xiuxiu Xu, Zhongjun Dong, Rui Sun, Zhigang Tian, Haiming Wei
Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is unclear. Here, we have identified a CD49a+ Eomes+ subset of NK cells that secreted growth-promoting factors (GPFs), including pleiotrophin and osteoglycin, in both humans and mice. The crosstalk between HLA-G and ILT2 served as a stimulus for GPF-secreting function of this NK cell subset. Decreases in this GPF-secreting NK cell subset impaired fetal development, resulting in fetal growth restriction...
December 19, 2017: Immunity
https://www.readbyqxmd.com/read/29215740/the-stat3-nfil3-signaling-axis-mediated-chemotherapy-resistance-is-reversed-by-raddeanin-a-via-inducing-apoptosis-in-choriocarcinoma-cells
#8
Zheng Peng, Chun Zhang, Wenjun Zhou, Chenchun Wu, Yi Zhang
Chemotherapy resistance is the major issue of choriocarcinoma. Apoptosis always is the ultimate outcome of chemotherapeutic drugs, which considered one of the reasons of resistance. We investigated the role of STAT3/NFIL3 signaling-inhibited apoptosis in chemotherapy resistance and whether Raddeanin A (RA) could be a new drug to reverse resistance. Established three drug-resistant cell lines as JEG-3/MTX, JEG-3/5-FU, and JEG-3/VP16. NFIL3 and STAT3 expression was evaluated in the cells. The IC50 value, apoptosis rate and apoptins were observed with transfection of siNFIL3, Lenti-OE™-NFIL3, shSTAT3, and Lenti-OE™-STAT3 or RA treatment...
July 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29132537/nfil3-is-a-negative-regulator-of-hepatic-gluconeogenesis
#9
Geon Kang, Hye-Sook Han, Seung-Hoi Koo
OBJECTIVE: Nuclear factor interleukin-3 regulated (NFIL3) has been known as an important transcriptional regulator of the development and the differentiation of immune cells. Although expression of NFIL3 is regulated by nutritional cues in the liver, the role of NFIL3 in the glucose metabolism has not been extensively studied. Thus, we wanted to explore the potential role of NFIL3 in the control of hepatic glucose metabolism. MATERIALS/METHODS: Mouse primary hepatocytes were cultured to perform western blot analysis, Q-PCR and chromatin immunoprecipitation assay...
December 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29097167/high-fat-diet-exposure-regardless-of-induction-of-obesity-is-associated-with-altered-expression-of-genes-critical-to-normal-ovulatory-function
#10
Natalie M Hohos, Kirstin J Cho, Delaney C Swindle, Malgorzata E Skaznik-Wikiel
We evaluated the impact of high-fat diet (HFD) on ovarian gene expression. Female 5-week-old C57BL/6J mice were fed a 60% HFD or standard chow for 10 weeks. HFD-fed mice were then separated into obese (HF-Ob) and lean (HF-Ln) based on body weight. HFD exposure led to impairment of the estrous cycle, changes in hormones affecting reproduction, and decreased primordial follicles regardless of the development of obesity. RNA-sequencing of whole ovaries identified multiple genes with altered expression after HFD, with 25 genes displaying decreased expression in both HF-Ln and HF-Ob mice compared to the chow-fed controls (q < 0...
October 30, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29095827/co-option-of-the-bzip-transcription-factor-vrille-as-the-activator-of-doublesex1-in-environmental-sex-determination-of-the-crustacean-daphnia-magna
#11
Nur Syafiqah Mohamad Ishak, Quang Dang Nong, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe
Divergence of upstream regulatory pathways of the transcription factor Doublesex (Dsx) serves as a basis for evolution of sex-determining mechanisms in animals. However, little is known about the regulation of Dsx in environmental sex determination. In the crustacean Daphnia magna, environmental sex determination is implemented by male-specific expression of the Dsx ortholog, Dsx1. Transcriptional regulation of Dsx1 comprises at least three phases during embryogenesis: non-sex-specific initiation, male-specific up-regulation, and its maintenance...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29024635/keeping-time-in-a-relay-race-for-fat
#12
COMMENT
Katya Frazier, Vanessa Leone
Gut microbes impact host metabolism via a multitude of mechanisms, including through host circadian rhythm regulation. How microbes influence host circadian networks remains unclear. Recently, Wang et al. (2017) showed that crosstalk between specific microbial components and innate immune cells tunes epithelial circadian oscillations via Nfil3, modulating lipid uptake and metabolism.
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28966997/lacrimal-gland-nk-cells-are-developmentally-and-functionally-similar-to-conventional-nk-cells
#13
Timothy Erick, Lilit Grigoryan, Laurent Brossay
The murine lacrimal gland (LG), which produces crucial components of the ocular tear film, contains a population of natural killer (NK) cells. LG NK cells appear to belong to the conventional NK cell lineage, based on their cell surface receptor and transcription factor expression, absence in NFIL3(-/-) mice, and lack of RORγt expression during development. LG NK cells produce IFN-γ during the early stages of systemic murine cytomegalovirus (MCMV) infection. This effector response occurs in the absence of noticeable MCMV replication in the LG, indicating that LG NK cells are being activated by soluble factors...
April 1, 2017: ImmunoHorizons
https://www.readbyqxmd.com/read/28951217/assessing-molecular-initiating-events-mies-key-events-kes-and-modulating-factors-mfs-for-styrene-responses-in-mouse-lungs-using-whole-genome-gene-expression-profiling-following-1-day-and-multi-week-exposures
#14
Melvin E Andersen, George Cruzan, Michael B Black, Salil N Pendse, Darol Dodd, James S Bus, Satinder S Sarang, Marcy I Banton, Robbie Waites, Patrick D McMullen
Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three strains of male mice (the parental C57BL/6 strain, a CYP2F2(-/-) knock out and a CYP2F2(-/-) transgenic containing human CYP2F1, 2A13 and 2B6). Exposures were for 1-day and 1, 4 and 26weeks. After 1-day exposures at 1, 5, 10, 20, 40 and 120ppm significant increases in differentially expressed genes (DEGs) occurred only in parental strain lungs where there was already an increase in DEGs at 5ppm and then many thousands of DEGs by 120ppm...
November 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28903366/systematic-analysis-of-coronary-artery-disease-datasets-revealed-the-potential-biomarker-and-treatment-target
#15
Yan Shi, Sijin Yang, Man Luo, Wei-Dong Zhang, Zun-Ping Ke
Coronary artery disease caused about 1 of every 7 deaths in the United States and early prevention was potential to decrease the incidence and mortality. We aimed to figure the genes involving in the coronary artery disease using meta-anlaysis. Five datasets of coronary heart disease from GEO series were retrieved and data preprocessing and quality control were carried out. Moderated t-test was used to decide the differentially expressed genes for a single dataset. And the combined p-value using systematic-analysis methods were conducted using MetaDE...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28886898/the-differential-organogenesis-and-functionality-of-two-liver-draining-lymph-nodes-in-mice
#16
Jiali Yu, Yongyan Chen, Yuzhang Wu, Lilin Ye, Zhexiong Lian, Haiming Wei, Rui Sun, Zhigang Tian
The liver is an immunological organ. However, fundamental knowledge concerning liver-draining lymph nodes (LNs), which have been newly identified in mice as the portal and celiac LNs, is still lacking. Here, we revealed that the portal LN and celiac LN drain liver lymph through different lymphatic vessels. Although both the portal LN and celiac LN possess typical structures, they have different cell compositions. Interestingly, these two LNs form at different times during fetal development. Moreover, the organogenesis of the celiac LN, but not the portal LN, is controlled by the transcription factor NFIL3...
November 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28860383/the-intestinal-microbiota-regulates-body-composition-through-nfil-3-and-the-circadian-clock
#17
Yuhao Wang, Zheng Kuang, Xiaofei Yu, Kelly A Ruhn, Masato Kubo, Lora V Hooper
The intestinal microbiota has been identified as an environmental factor that markedly affects energy storage and body-fat accumulation in mammals, yet the underlying mechanisms remain unclear. Here we show that the microbiota regulates body composition through the circadian transcription factor NFIL3. Nfil3 transcription oscillates diurnally in intestinal epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells, STAT3 (signal transducer and activator of transcription 3), and the epithelial cell circadian clock...
September 1, 2017: Science
https://www.readbyqxmd.com/read/28752422/regulation-of-clock-genes-by-adrenergic-receptor-signaling-in-osteoblasts
#18
Takao Hirai
The clock system has been identified as one of the major mechanisms controlling cellular functions. Circadian clock gene oscillations also actively participate in the functions of various cell types including bone-related cells. Previous studies demonstrated that clock genes were expressed in bone tissue and also that their expression exhibited circadian rhythmicity. Recent findings have shown that sympathetic tone plays a central role in biological oscillations in bone. Adrenergic receptor (AR) signaling regulates the expression of clock genes in cancellous bone...
January 2018: Neurochemical Research
https://www.readbyqxmd.com/read/28729066/the-effect-of-high-fat-diet-on-daily-rhythm-of-the-core-clock-genes-and-muscle-functional-genes-in-the-skeletal-muscle-of-chinese-soft-shelled-turtle-trionyx-sinensis
#19
Li Liu, Guomin Jiang, Zhitao Peng, Yulong Li, Jinlong Li, Li Zou, Zhigang He, Xiaoqing Wang, Wuying Chu
In the present study, we sought to investigate the influence of high fat diet on the core clock genes and the muscle functional genes daily expression in the skeletal muscle of Chinese soft-shelled turtle. The turtles were fed by two diets including a control fat diet (the CON treatment, 7.98% lipid) and a high fat diet (the HFD treatment, 13.86% lipid) for six weeks and administrated by the photophase regimen of 24h light/dark (12L:12D) cycle. After the feeding trial experiment, we measured the daily expression levels of 17 core clock genes (Clock, Bmal1/2, NPAS2, Tim, Cry1/2, Per1/2, DBP, AANAT, NIFL3, BHLHE40, NR1D2, RORA, RORB, RORC) and 12 muscle functional genes (FBXO32, MBNL1, MSTN, Myf5, Myf6, MyoD, MyoG, MyoM1, PPARa, PDK4, Trim63, UCP3) in the skeletal muscle of the two treatments...
November 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28705996/different-gene-response-to-mechanical-loading-during-early-and-late-phases-of-rat-achilles-tendon-healing
#20
Malin Hammerman, Parmis Blomgran, Arie Dansac, Pernilla Eliasson, Per Aspenberg
Mechanical loading stimulates tendon healing both when applied in the inflammatory phase and in the early remodeling phase of the process, although not necessarily via the same mechanisms. We investigated the gene response to mechanical loading in these two phases of tendon healing. The right Achilles tendon in rats was transected and the hind limbs were unloaded by tail suspension. The rats were exposed to 5 minutes of treadmill running 3 or 14 days after tendon transection. Thereafter, they were re-suspended for 15 minutes or 3 hours until euthanasia...
July 13, 2017: Journal of Applied Physiology
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