keyword
https://read.qxmd.com/read/38268484/irf1-deficiency-predisposes-cartilage-to-accumulate-dna-damage-and-promotes-osteoarthritis-development
#21
JOURNAL ARTICLE
Yongsik Cho, Hyeonkyeong Kim, Geunho Yook, Sangmin Yong, Soy Kim, Narae Lee, Yi-Jun Kim, Jin-Hee Kim, Tae Woo Kim, Moon Jong Chang, Kyoung Min Lee, Chong Bum Chang, Seung-Baik Kang, Jin-Hong Kim
OBJECTIVE: Interferon regulatory factor 1 (IRF1) is a transcriptional regulator conventionally associated with immunomodulation. Recent molecular analyses mapping DNA binding sites of IRF1 have suggested its potential function in DNA repair. However, the physiological significance of this non-canonical function remains unexplored. Here, we investigated IRF1's role in osteoarthritis (OA), a condition marked by senescence and chronic joint inflammation. METHODS: OA progression was examined in wild-type and Irf1-/- mice using histological assessments and micro-computed tomography (μCT) analysis of whole-joint OA manifestations, and behavioral assessments of joint pain...
January 25, 2024: Arthritis & Rheumatology
https://read.qxmd.com/read/38262159/porcine-platelet-lysates-exert-the-efficacy-of-chondroregeneration-and-smad2-mediated-anti-chondrofibrosis-on-knee-osteoarthritis
#22
JOURNAL ARTICLE
Xiujuan Xiao, Jiaan Xu, Chen Wang, Zhijiang Jin, Qiang Yuan, Li Zhou, Letian Shan
BACKGROUND: The lack of self-repairability in cartilage and the formation of fibrocartilage pose significant challenges in treating knee osteoarthritis, and there is still no ideal solution. Autologous platelet lysates have been clinically applied to treat kOA and exert satisfactory cartilage-repair efficacy, but the preparation of human PL brings damage to patients and is hardly standardized. METHODS: In this study, porcine PL was developed to replace hPL, and its chondroregenerative and anti-chondrofibrosis effects were explored...
February 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38259052/hierarchically-assembled-nanofiber-scaffold-guides-long-bone-regeneration-by-promoting-osteogenic-chondrogenic-differentiation-of-endogenous-mesenchymal-stem-cells
#23
JOURNAL ARTICLE
Hao Pan, Yuxuan Wei, Canjun Zeng, Ganghua Yang, Chao Dong, Wenbing Wan, Shixuan Chen
Critical-sized segmental long bone defects represent a challenging clinical dilemma in the management of battlefield and trauma-related injuries. The residual bone marrow cavity of damaged long bones contains many bone marrow mesenchymal stem cells (BMSCs), which provide a substantial source of cells for bone repair. Thus, a three-dimensional (3D) vertically aligned nanofiber scaffold (VAS) is developed with long channels and large pore size. The pore of VAS toward the bone marrow cavity after transplantation, enables the scaffolds to recruit BMSCs from the bone marrow cavity to the defect area...
January 23, 2024: Small
https://read.qxmd.com/read/38249650/autologous-chondrocyte-implantation-with-collagen-membrane-using-a-knotless-suture-bridge-technique
#24
Toshihiro Seki, Kazushige Seki, Takashi Imagama, Tomoya Okazaki, Takashi Sakai
Autologous chondrocyte implantation (ACI) has been covered by insurance in Japan since April 2013, expanding the range of treatments for extensive knee cartilage damage. Initially, the periosteum was used for the fixation of cultured cartilage, but since February 2019, the introduction of collagen membranes has shortened surgery time and simplified the procedure. We report a case where we used the knotless suture bridge technique for a more straightforward and secure fixation with a collagen membrane. The patient was a 61-year-old male who experienced right knee pain a year earlier when stepping downstairs...
January 2024: Curēus
https://read.qxmd.com/read/38238809/comparison-of-immediate-versus-optional-delayed-surgical-repair-for-treatment-of-acute-anterior-cruciate-ligament-injury-through-a-parallel-multicentric-pragmatic-randomized-controlled-trial-ioda-trial
#25
JOURNAL ARTICLE
Annemie Smeets, Feryal Ghafelzadeh Ahwaz, Stijn Bogaerts, Pieter Berger, Koen Peers
BACKGROUND: Standard care for anterior cruciate ligament (ACL) injuries often includes surgical reconstruction of the ACL. However, two randomized controlled trials [1, 2] (RCT) concluded that conservative treatment does not result in inferior clinical outcomes compared to immediate ACL reconstruction. More research is needed to verify these results and assess whether patient-specific parameters determine if a patient would benefit from one treatment option over the other. METHODS: This is a pragmatic, multi-center RCT with two parallel groups...
January 18, 2024: BMC Sports Science, Medicine and Rehabilitation
https://read.qxmd.com/read/38227139/future-of-low-back-pain-unravelling-ivd-components-and-mscs-potential
#26
REVIEW
Raquel Leão Monteiro
Low back pain (LBP) mainly emerges from intervertebral disc (IVD) degeneration. However, the failing mechanism of IVD ́s components, like the annulus fibrosus (AF) and nucleus pulposus (NP), leading to IVD degeneration/herniation is still poorly understood. Moreover, the specific role of cellular populations and molecular pathways involved in the inflammatory process associated with IVD herniation remains to be highlighted. The limited knowledge of inflammation associated with the initial steps of herniation and the lack of suitable models to mimic human IVD ́s complexity are some of the reasons for that...
January 16, 2024: Cell Regeneration
https://read.qxmd.com/read/38226734/significant-improvements-in-clinical-outcome-measures-and-patient-satisfaction-after-combined-all-arthroscopic-meniscal-allograft-transplantation-and-autologous-chondrocyte-implantation-a-single-centre-longitudinal-study
#27
JOURNAL ARTICLE
Johannes Pawelczyk, Ilias Fanourgiakis, Sven Feil, Rainer Siebold
PURPOSE: The optimal treatment approach for the complex pathology of meniscal insufficiency and coexisting full-thickness cartilage defects remains unclear. The purpose of this study was to evaluate the viability, safety, and efficacy of this combined surgical approach at medium-term follow-up. METHODS: This is a single-centre longitudinal study with blinded outcome assessment. All consecutive patients treated with combined all-arthroscopic meniscal allograft transplantation (MAT) with bone bridge fixation and ACI using chondrospheres at our institution between 2001 and 2021 were eligible for inclusion...
January 2024: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/38204795/functional-performance-of-a-bi-layered-chitosan-nano-hydroxyapatite-osteochondral-scaffold-a-pre-clinical-in-vitro-tribological-study
#28
JOURNAL ARTICLE
Raelene M Cowie, Laura Macri-Pellizzeri, Jane McLaren, William J Sanderson, Reda M Felfel, Colin A Scotchford, Brigitte E Scammell, David M Grant, Virginie Sottile, Louise M Jennings
Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different graft sources/materials which replicate natural cartilage function. Chitosan has been proposed for this application. The aim of this study was to assess the biomechanics and biotribology of a bioresorbable chitosan/chitosan-nano-hydroxyapatite osteochondral construct (OCC), implanted in an in vitro porcine knee experimental simulation model...
January 2024: Royal Society Open Science
https://read.qxmd.com/read/38203565/advances-in-stem-cell-based-therapies-in-the-treatment-of-osteoarthritis
#29
REVIEW
Ye Chen, Rui-Juan Cheng, Yinlan Wu, Deying Huang, Yanhong Li, Yi Liu
Osteoarthritis (OA) is a chronic, degenerative joint disease presenting a significant global health threat. While current therapeutic approaches primarily target symptom relief, their efficacy in repairing joint damage remains limited. Recent research has highlighted mesenchymal stem cells (MSCs) as potential contributors to cartilage repair, anti-inflammatory modulation, and immune regulation in OA patients. Notably, MSCs from different sources and their derivatives exhibit variations in their effectiveness in treating OA...
December 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38194734/mitochondrial-targeting-and-nir-responsive-mn-3-o-4-pda-pd-ss31-nanozymes-reduce-oxidative-stress-and-reverse-mitochondrial-dysfunction-to-alleviate-osteoarthritis
#30
JOURNAL ARTICLE
Yuquan Li, Junxu Yang, Xiaoming Chen, Hao Hu, Nihan Lan, Jinmin Zhao, Li Zheng
Mitochondrial reactive oxygen species (mROS) play a crucial role in the process of osteoarthritis (OA), which may be a promising target for therapy of OA. In this study, novel mitochondrial-targeting and SOD-mimic Mn3 O4 @PDA@Pd-SS31 nanozymes with near-infrared (NIR) responsiveness and synergistic cascade to scavenge mROS were designed for the therapy of OA. Results showed that the nanozymes accelerated the release of Pd and Mn3 O4 under NIR irradiation, exhibiting enhanced activities of SOD and CAT mimic enzymes with reversed mitochondrial dysfunction and promoted mitophagy to effectively scavenge mROS from chondrocytes, modulate the microenvironment of oxidative stress, and eventually inhibit the inflammatory response...
December 22, 2023: Biomaterials
https://read.qxmd.com/read/38192148/human-adipose-derived-stem-cells-upregulate-igf-1-and-alleviate-osteoarthritis-in-a-two-stage-rabbit-osteoarthritis-model
#31
JOURNAL ARTICLE
Juan Wang, Shibo Su, Chuanming Dong, Qiang Fan, Jishu Sun, Siqing Liang, Zuhuo Qin, Chuqing Ma, Jianfeng Jin, Hongwen Zhu, Tongmeng Jiang, Jun Xu
OBJECTIVE: In recent years, it has been known that mesenchymal stem cells (MSCs) have the potential to treat osteoarthritis (OA). This study aimed to investigate the effects of intraarticular injection of human adipose-derived stem cells (hADSCs) in a new double-damage rabbit osteoarthritis model. METHODS: The OA model was established surgically first by medial collateral ligament and anterior insertional ligament transection and medical meniscectomy, then by articular cartilage full-thickness defect...
January 8, 2024: Current Stem Cell Research & Therapy
https://read.qxmd.com/read/38189958/-treatment-of-osteochondritis-dissecans
#32
JOURNAL ARTICLE
Franziska Breulmann, Julian Mehl, Alexander Otto, Sebastian Lappen, Sebastian Siebenlist, Peter Rab
Osteochondritis dissecans (OD) is a rare condition with an incidence of 30/100,000. It especially affects male patients aged 10-20 years old. During the staged progression the osteochondral fragments can detach from their base. These can damage the adjacent articular cartilage, which can lead to premature osteoarthritis. Most commonly affected are the knee, ankle and elbow joints. The exact pathogenesis of OD has so far not been clearly confirmed. Several risk factors that can lead to the development of OD are discussed...
January 8, 2024: Orthopadie (Heidelb)
https://read.qxmd.com/read/38179226/recent-advances-in-3d-bioprinted-cartilage-mimicking-constructs-for-applications-in-tissue-engineering
#33
REVIEW
Jian Zhou, Qi Li, Zhuang Tian, Qi Yao, Mingzhu Zhang
Human cartilage tissue can be categorized into three types: hyaline cartilage, elastic cartilage and fibrocartilage. Each type of cartilage tissue possesses unique properties and functions, which presents a significant challenge for the regeneration and repair of damaged tissue. Bionics is a discipline in which humans study and imitate nature. A bionic strategy based on comprehensive knowledge of the anatomy and histology of human cartilage is expected to contribute to fundamental study of core elements of tissue repair...
December 2023: Materials today. Bio
https://read.qxmd.com/read/38169139/ph-and-ros-dual-sensitive-nanocarriers-for-the-targeted-co-delivery-and-on-demand-sequential-release-of-tofacitinib-and-glucosamine-for-synergistic-rheumatoid-arthritis-treatment
#34
JOURNAL ARTICLE
Guo Chen, Shaohui Deng, Shubo Liu, Yuexin Zhao, Yuanqiang Xiao, Xiangming Zeng, Yafei Xu, Du Cheng, Bin Chen
Rheumatoid arthritis (RA) progression involves multiple cell types, and sequential drug action on target cells is necessary for RA treatment. Nanocarriers are widely used for RA treatment; however, the targeted delivery and on-demand release of multiple drugs remains challenging. Therefore, in this study, a dual-sensitive polymer is developed using chondroitin sulfate (CS) for the co-delivery of the cartilage repair agent, glucosamine (GlcN), and anti-inflammatory drug, tofacitinib (Tof). In the joint cavity, acidic pH facilitates the cleavage of GlcN from CS polymer to repair the cartilage damage...
January 2, 2024: Small
https://read.qxmd.com/read/38137403/in-vitro-chondrogenesis-induction-by-short-peptides-of-the-carboxy-terminal-domain-of-transforming-growth-factor-%C3%AE-1
#35
JOURNAL ARTICLE
Maria Pitou, Eleni Papachristou, Dimitrios Bratsios, Georgia-Maria Kefala, Anastasia S Tsagkarakou, Demetrios D Leonidas, Amalia Aggeli, Georgios E Papadopoulos, Rigini M Papi, Theodora Choli-Papadopoulou
Τransforming growth factor β1 (TGF-β1) comprises a key regulator protein in many cellular processes, including in vivo chondrogenesis. The treatment of human dental pulp stem cells, separately, with Leu83 -Ser112 (C-terminal domain of TGF-β1), as well as two very short peptides, namely, 90-YYVGRKPK-97 (peptide 8) and 91-YVGRKP-96 (peptide 6) remarkably enhanced the chondrogenic differentiation capacity in comparison to their full-length mature TGF-β1 counterpart either in monolayer cultures or 3D scaffolds...
November 29, 2023: Biomedicines
https://read.qxmd.com/read/38132932/recent-advances-in-marine-biomaterials-tailored-and-primed-for-the-treatment-of-damaged-soft-tissues
#36
REVIEW
Moon Sung Kang, Hyo Jung Jo, Hee Jeong Jang, Bongju Kim, Tae Gon Jung, Dong-Wook Han
The inherent self-repair abilities of the body often fall short when it comes to addressing injuries in soft tissues like skin, nerves, and cartilage. Tissue engineering and regenerative medicine have concentrated their research efforts on creating natural biomaterials to overcome this intrinsic healing limitation. This comprehensive review delves into the advancement of such biomaterials using substances and components sourced from marine origins. These marine-derived materials offer a sustainable alternative to traditional mammal-derived sources, harnessing their advantageous biological traits including sustainability, scalability, reduced zoonotic disease risks, and fewer religious restrictions...
November 25, 2023: Marine Drugs
https://read.qxmd.com/read/38126258/degree-of-articular-injury-as-measured-by-ct-cross-sectional-area-is-associated-with-physical-function-following-the-treatment-of-bicondylar-tibial-plateau-fractures
#37
JOURNAL ARTICLE
Arvind von Keudell, Kyla D Huebner, Jacob Mandell, Matthew O'Brien, Mitchel B Harris, John G Esposito, Tyler Caton, Michael J Weaver
BACKGROUND: Bicondylar tibial plateau fractures are complex injuries that commonly require surgical repair. Long-term clinical outcome has been associated with discrepancies in leg alignment, instability and condylar width abnormalities. While intuitive, the degree of articular damage at time of injury has not been linked to outcomes in patients with bicondylar tibial plateau fractures. The aim of this study was to quantify percentage of articular surface cross sectional area disruption and assess for correlation between the degree of articular injury and patient reported physical function...
2023: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/38123467/preoperative-radiographs-underdiagnose-the-severity-of-lateral-femoral-and-medial-trochlear-cartilage-damage-in-varus-osteoarthritis-knees
#38
JOURNAL ARTICLE
Takahiro Maeda, Shinichi Kuriyama, Takayuki Ito, Naoki Umatani, Kohei Nishitani, Shinichiro Nakamura, Shuichi Matsuda
OBJECTIVE: This study evaluated whether preoperative radiographs accurately predicted intra-articular cartilage damage in varus knees. METHODS: The study assessed 181 knees in 156 patients who underwent total knee arthroplasty. Cartilage damage was graded by two examiners with the International Cartilage Repair Society (ICRS) classification; one used knee radiographs and the other used intraoperative photographs. It was then determined if this radiographic cartilage assessment over- or underestimated the actual damage severity...
December 20, 2023: Modern Rheumatology
https://read.qxmd.com/read/38123276/editorial-commentary-in-terms-of-hip-arthroscopy-long-term-outcomes-intra-articular-cartilage-damage-is-more-important-than-hip-labral-treatment-method-the-second-habit-of-highly-effective-surgeons
#39
EDITORIAL
Itay Ron, Mitch Yelton, Jacob Shapira
There is a large debate revolving around the optimal surgical management of hip labral tears. Currently, the literature tends to gravitate toward labral repair as the mainstay of treatment, followed by labral reconstruction when repair is not feasible. Some studies assert that there is no difference between labral repair versus debridement, whereas others support repair. Other studies support labral reconstruction. In the end, it is the quality of the cartilage that may be most important. Intra-articular cartilage damage is more important than the labral treatment method when it comes to hip arthroscopy long-term outcomes...
January 2024: Arthroscopy
https://read.qxmd.com/read/38102700/cd146-positive-adipose-derived-stem-cells-subpopulation-enriched-by-albumin-magnetic-sphere-ameliorates-knee-osteoarthritis-pain-and-promotes-cartilage-repair
#40
JOURNAL ARTICLE
Lianghao Wu, Xu Zhang, Chengqing Yi, Hanru Ren
BACKGROUND: The use of adipose stem cell (ADSCs) subpopulations in cartilage repair remains poorly characterized. In this study, we constructed an albumin magnetic sphere with specific targeting of CD146 (CD146-AMs) for sorting a subpopulation of CD146-positive ADSCs (CD146 + ADSCs) and explored the role of CD146 + ADSCs on joint pain and cartilage repair in rats with knee osteoarthritis (KOA). METHODS: CD146-AMs were prepared and analyzed in materialistic characterization tests...
December 15, 2023: Journal of Orthopaedic Surgery and Research
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