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Cartilage repair and damage

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https://www.readbyqxmd.com/read/29792508/effects-of-tgf-%C3%AE-overexpression-via-raav-gene-transfer-on-the-early-repair-processes-in-an-osteochondral-defect-model-in-minipigs
#1
Magali Cucchiarini, Ann-Kathrin Asen, Lars Goebel, Jagadeesh K Venkatesan, Gertrud Schmitt, David Zurakowski, Michael D Menger, Matthias W Laschke, Henning Madry
BACKGROUND: Application of the chondrogenic transforming growth factor beta (TGF-β) is an attractive approach to enhance the intrinsic biological activities in damaged articular cartilage, especially when using direct gene transfer strategies based on the clinically relevant recombinant adeno-associated viral (rAAV) vectors. PURPOSE: To evaluate the ability of an rAAV-TGF-β construct to modulate the early repair processes in sites of focal cartilage injury in minipigs in vivo relative to control (reporter lacZ gene) vector treatment...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29770595/repair-potential-of-non-surgically-delivered-induced-pluripotent-stem-cell-derived-chondrocytes-in-a-rat-osteochondral-defect-model
#2
Yeri Alice Rim, Yoojun Nam, Narae Park, Jennifer Lee, Sung-Hwan Park, Ji Hyeon Ju
Human induced pluripotent stem cells (hiPSCs) are thought to be an alternative cell source for future regenerative medicine. hiPSCs may allow unlimited production of cell types that have low turnover rates and are difficult to obtain such as autologous chondrocytes. In this study, we generated hiPSC-derived chondrogenic pellets and chondrocytes were isolated. To confirm the curative effects, chondrogenic pellets and isolated chondrocytes were transplanted into rat joints with osteochondral defects. Isolated hiPSC-derived chondrocytes were delivered in the defect by a single intra-articular injection...
May 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29769537/a-co-culture-system-of-rat-synovial-stem-cells-and-meniscus-cells-promotes-cell-proliferation-and-differentiation-as-compared-to-mono-culture
#3
Xing Xie, Jingxian Zhu, Xiaoqing Hu, Linghui Dai, Xin Fu, Jiying Zhang, Xiaoning Duan, Yingfang Ao
A meniscus tear often happens during active sports. It needs to be repaired or replaced surgically to avoid further damage to the articular cartilage. To address the shortage of autologous meniscal cells, we designed a co-culture system of synovial stem cells (SMSCs) and meniscal cells (MCs) to produce a large cell number and to maintain characteristics of MCs. Different ratios of SMSCs and MCs at 3:1, 1:1, and 1:3 were tested. Mono-culture of SMSCs or MCs served as control groups. Proliferation and differentiation abilities were compared...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765416/combating-osteoarthritis-through-stem-cell-therapies-by-rejuvenating-cartilage-a-review
#4
REVIEW
Navneet Kumar Dubey, Viraj Krishna Mishra, Rajni Dubey, Shabbir Syed-Abdul, Joseph R Wang, Peter D Wang, Win-Ping Deng
Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29756586/the-review-of-nanomaterials-inducing-the-differentiation-of-stem-cells-into-chondrocyte-phenotypes-in-cartilage-tissue-engineering
#5
Xueping Xie, Qi Zhang, Tengfei Zhou, Quanquan Ma, Liao JinFeng
Cartilage, as a nanostructured tissue, because of its awfully poor capacity for inherent regeneration and complete hierarchical structure, is severely difficult to regenerate after damages. Tissue engineering methods have provided great contribution for cartilage repair. Nanomaterials have special superiority in regulating stem cell behaviors due to their special mechanical and biological properties and biomimetic characteristics, therefore, they have been given great attention in tissue regeneration. Nanomaterials are divided into organic and inorganic nanomaterials...
May 11, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29754519/the-role-of-imaging-in-early-diagnosis-and-prevention-of-joint-damage-in-inflammatory-arthritis
#6
Jiang Yue, Dongze Wu, Lai-Shan Tam
Inflammatory arthritis is characterized by chronic inflammation in the synovium, associated with degradation of cartilage and erosion of juxta-articular bone. The bone loss and joint destruction mediated by aberrant immunological responses resulting in proinflammatory cytokine release and various immune cell activation are known as osteoimmunology. Areas covered: A structured literature search including Medline and PubMed, Cochrane meta-analyses and abstracts of international congresses was performed to review joint damage in inflammatory arthritis in terms of pathogenesis, novel imaging assessment and prevention...
May 13, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29746554/effects-of-collagen-matrix-and-bioreactor-cultivation-on-cartilage-regeneration-of-a-full-thickness-critical-size-knee-joint-cartilage-defects-with-subchondral-bone-damage-in-a-rabbit-model
#7
Kuo-Hwa Wang, Richard Wan, Li-Hsuan Chiu, Yu-Hui Tsai, Chia-Lang Fang, John F Bowley, Kuan-Chou Chen, Hsin-Nung Shih, Wen-Fu Thomas Lai
Cartilage has limited self-repair ability. The purpose of this study was to investigate the effects of different species of collagen-engineered neocartilage for the treatment of critical-size defects in the articular joint in a rabbit model. Type II and I collagen obtained from rabbits and rats was mixed to form a scaffold. The type II/I collagen scaffold was then mixed with rabbit chondrocytes to biofabricate neocartilage constructs using a rotating cell culture system [three-dimensional (3D)-bioreactor]. The rabbit chondrocytes were mixed with rabbit collagen scaffold and rat collagen scaffold to form neoRBT (neo-rabbit cartilage) and neoRAT (neo-rat cartilage) constructs, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29736579/combination-of-polymeric-supports-and-drug-delivery-systems-for-osteochondral-regeneration
#8
Luis Rojo
Musculoskeletal conditions have been defined by European National Health systems as one of the key themes which should be featured during the present decade as a consequence of the significant healthcare and social support costs. Among others, articular cartilage degeneration due to traumatic and degenerative lesion injury or other pathologies commonly results in the development of musculoskeletal disorders such as osteoarthritis and arthritis rheumatoid, eventually leading to progressive articular cartilage and joint destruction especially at osteochondral interphase, that account for more disability among the elderly than any other diseases constituting a global social challenge that needs a multidisciplinary response from the scientific community...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29736578/enhancing-biological-and-biomechanical-fixation-of-osteochondral-scaffold-a-grand-challenge
#9
Maryam Tamaddon, Chaozong Liu
Osteoarthritis (OA) is a degenerative joint disease, typified by degradation of cartilage and changes in the subchondral bone, resulting in pain, stiffness and reduced mobility. Current surgical treatments often fail to regenerate hyaline cartilage and result in the formation of fibrocartilage. Tissue engineering approaches have emerged for the repair of cartilage defects and damages to the subchondral bones in the early stage of OA and have shown potential in restoring the joint's function. In this approach, the use of three-dimensional scaffolds (with or without cells) provides support for tissue growth...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29734152/cell-sheet-engineering-and-kidney-diseases
#10
Masatoshi Oka, Yoei Miyabe, Naoko Sugiura, Kosaku Nitta
Treatment using the cell sheet technology has been applied to various organs, including the cornea, heart, esophagus, periodontium, cartilage, middle ear, and lungs. It has been shown that the therapeutic efficacy of cell sheet transplantation involves 2 aspects, supplementation of cells and provision of cytokines to the affected organ. In addition, cell sheet transplantation also promotes repair of damage through the paracrine effects of cytokines derived from the transplanted cells. It is known that in cases of cell transplantation by injection, the transplanted cells are less likely to differentiate into renal tissue to supply cells, but repair is promoted by the actions of the transplanted cell-derived renotropic factors...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29734010/icariin-conjugated-hyaluronic-acid-collagen-hydrogel-for-osteochondral-interface-restoration
#11
Jirong Yang, Yanbo Liu, Long He, Qiguang Wang, Lan Wang, Tun Yuan, Yumei Xiao, Yujiang Fan, Xingdong Zhang
Over the past decades, numerous tissue-engineered constructs have been investigated for the osteochondral repair. However, it still remains a challenge to regenerate the functionalized calcified layer. In this study, the potential of icariin (Ica) conjugated hyaluronic acid/collagen (Ica-HA/Col) hydrogel to promote the osteochondral interface restoration was investigated. Compared with HA/Col hydrogel, Ica-HA/Col hydrogel simultaneously facilitated chondrogenesis and osteogenesis in vitro. The cells encapsulated in Ica-HA/Col hydrogel tended to aggregate into bigger clusters...
May 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29732992/current-status-of-stem-cell-therapies-in-tissue-repair-and-regeneration
#12
Tapan Kumar Giri, Amit Alexander, Mukta Agrawal, Swarnalata Saraf, Shailendra Saraf, Ajazuddin
Tissue engineering is a multi-disciplinary field such as material science, life science, and bioengineering that are necessary to make artificial tissue or rejuvenate damaged tissue. Numerous tissue repair techniques and substitute now exist even though it has several shortcomings; these shortcomings give a good reason for the continuous research for more acceptable tissue-engineered substitutes. The search for and use of a suitable stem cell in tissue engineering is a promising concept. Stem cells have a distinctive capability to differentiate and self-renew that make more suitable for cell-based therapies in tissue repair and regeneration...
May 1, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29730219/prevalence-of-high-grade-cartilage-defects-in-patients-with-borderline-dysplasia-with-femoroacetabular-impingement-a-comparative-cohort-study
#13
Ioanna K Bolia, Karen K Briggs, Renato Locks, Jorge Chahla, Hajime Utsunomiya, Marc J Philippon
PURPOSE: To compare the prevalence, size, and location of Outerbridge grade III and IV cartilage defects on the femoral head and acetabulum between patients with borderline acetabular dysplasia and patients with non-borderline dysplasia who underwent hip arthroscopy for femoroacetabular impingement (FAI). METHODS: Patients aged 18 years or older who underwent primary hip arthroscopy for correction of FAI and labral repair from November 2005 to April 2016 were included...
May 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29725380/tgf-%C3%AE-3-reduces-apoptosis-in-ischemia-induced-adipose-derived-stem-cells-by-enhancing-dna-repair
#14
Fan Wu, Haiwen Ye, Junfeng Lin, Yaodong Xu, Zhuasong Zhang, Hao Xiong, Maojin Laing, Yiqing Zhen, Suijun Chen
Adipose-derived stem cells (ADSCs) possess good proliferative and differentiative abilities, making then a promising candidate for the treatment of cartilage defects. However, local ischemia often causes apoptosis in ADSCs. Transforming growth factor-β3 (TGF-β3) is often used as a chondrogenic differentiation cytokine whose function in apoptosis is unclear. The aim of the present study was to investigate the role of TGF-β3 in ischemia-induced ADSC apoptosis. In the present study, the phenotypes and multipotent differentiation properties of human ADSCs at passage 3 were analyzed using flow cytometry and cytochemical staining...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29722767/amniotic-epithelial-stem-cells-salient-features-and-possible-therapeutic-role
#15
Aurelio Muttini, Barbara Barboni, Luca Valbonetti, Valentina Russo, Nicola Maffulli
This is a study of amniotic epithelial cells, which form the innermost layer of the amniotic membrane. These cells can be easily isolated and display peculiar and unique properties, such as plasticity and differentiation potential toward the 3 germinal layers, that may aid regeneration and/or repair of damaged or diseased tissues and organs. A robust literature based on in vitro, experimental, and clinical studies in large animals demonstrates that these cells can enhance the regeneration of tendons, bone, and articular cartilage...
June 2018: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29706246/cross-sectional-area-measurement-of-the-central-tarsometatarsal-articulation-a-review-of-computed-tomography-scans
#16
John Randolph Clements, Kelley Whitmer, Hoa Nguyen, Matthew Rich
Currently, disagreement exists regarding the superior method for repairing a ligamentous Lisfranc injury regarding whether to use arthrodesis or open reduction internal fixation. The 2 procedures differ in the amount of articular cartilage destroyed. Arthrodesis removes all the articular cartilage, and open reduction internal fixation places transarticular screws, essentially destroying a portion of cartilage. We performed a review of 30 consecutive computed tomography scans that included both foot length and undamaged first, second, and third tarsometatarsal joints to quantify the amount of articular surface area destroyed by placement of standardized 4-mm diameter screws...
April 26, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29696319/danish-hip-arthroscopy-registry-predictors-of-outcome-in-patients-with-femoroacetabular-impingement-fai
#17
Bjarne Mygind-Klavsen, Bent Lund, Torsten Grønbech Nielsen, Niels Maagaard, Otto Kraemer, Per Hölmich, Søren Winge, Martin Lind
PURPOSE: Predictors of outcome after femoroacetabular impingement (FAI) surgery are not well-documented. This study presents data from the Danish Hip Arthroscopy Registry (DHAR) for such analyses. The purpose of this study was to identify predictors of poor outcome after FAI surgery in a Danish FAI population. The primary hypothesis was that older patients, patients with severe cartilage damage and female patients might have inferior outcome results compared with younger patients, patients with minor cartilage damage and male patients...
April 25, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29693133/isolation-and-biological-characteristic-evaluation-of-a-novel-type-of-cartilage-stem-progenitor-cell-derived-from-small%C3%A2-tailed-han-sheep-embryos
#18
Caiyun Ma, Tengfei Lu, Hebao Wen, Yanjie Zheng, Xiao Han, Xongda Ji, Weijun Guan
Cartilage stem/progenitor cells (CSPCs) are a novel stem cell population and function as promising therapeutic candidates for cell‑based cartilage repair. Until now, numerous existing research materials have been obtained from humans, horses, cows and other mammals, but rarely from sheep. In the present study, CSPCs with potential applications in repairing tissue damage and cell‑based therapy were isolated from 45‑day‑old Small‑tailed Han Sheep embryos, and examined at the cellular and molecular level...
April 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29692872/control-of-articular-synovitis-for-bone-and-cartilage-regeneration-in-rheumatoid-arthritis
#19
REVIEW
Hiromu Ito, Furu Moritoshi, Motomu Hashimoto, Masao Tanaka, Shuichi Matsuda
Background: Rheumatoid arthritis is an autoimmune inflammatory disease, the specific feature of which is progressive joint destruction induced by synovitis. The universal consensus is that alleviation of the synovitis is essential to prevent joint destruction and achieve clinical remission. Main text: We have shown that not only achieving but also maintaining remission is crucial to prevent the progression of joint destruction. Although regeneration of the damaged joints is considered very rare, accumulating evidence shows that it actually occurs in routine clinical practice as a result of strong inhibition of synovitis using highly potent medications...
2018: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29691829/in-situ-cross-linkable-polymer-systems-and-composites-for-osteochondral-regeneration
#20
María Puertas-Bartolomé, Lorena Benito-Garzón, Marta Olmeda-Lozano
Injectable hydrogels have demonstrated being a promising strategy for cartilage and bone tissue engineering applications, owing to their minimal invasive injection procedure, easy incorporation of cells and bioactive molecules, improved contact with the surrounding tissues and ability to match defects with complex irregular shapes, characteristics of osteoarthritic pathology. These unique properties make them highly suitable bioscaffolds for treating defects which are otherwise not easily accessible without and invasive surgical procedure...
2018: Advances in Experimental Medicine and Biology
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