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Cartilage repair and damage

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https://www.readbyqxmd.com/read/29349030/augmentation-of-patellar-tendon-repair-with-autologous-semitendinosus-graft-porto-technique
#1
João Espregueira-Mendes, Renato Andrade, M J S Fredrick Michael, André Sarmento, Nuno Sevivas, Rui Rocha, Ricardo Bastos Filho
Patellar tendon ruptures can lead to significant functional deficiency of the extensor mechanism of the knee. These injuries, because of their inherent nature and associated complications, may require a complex treatment and remains a challenge for orthopaedic surgeons. Current surgical techniques present significant complications, including patellar fracture, damage to patellar articular cartilage, and abnormal patella height. This note describes a surgical technique to provide an additional reinforcement to the patellar tendon repair with a semitendinous autograft, without the necessity to perform any transosseous tunnels at the patella bone...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29337200/mimicking-the-3d-biology-of-osteochondral-tissue-with-microfluidic-based-solutions-breakthroughs-towards-boosting-drug-testing-and-discovery
#2
REVIEW
Mariana R Carvalho, Rui Luís Reis, Joaquim Miguel Oliveira
The development of tissue-engineering (TE) solutions for osteochondral (OC) regeneration has been slowed by technical hurdles related to the recapitulation of their complex and hierarchical architecture. OC defects refer to damage of both the articular cartilage and the underlying subchondral bone. To repair an OC tissue defect, the complexity of the bone and cartilage must be considered. To help achieve this, microfluidics is converging with TE approaches to provide new treatment possibilities. Microfluidics uses precise micrometer-to-millimeter-scale fluid flows to achieve high-resolution and spatial and/or temporal control of the cell microenvironment, providing powerful tools for cell culturing...
January 11, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29316363/exploiting-advanced-hydrogel-technologies-to-address-key-challenges-in-regenerative-medicine
#3
REVIEW
Daniel A Foyt, Michael D A Norman, Tracy T L Yu, Eileen Gentleman
Regenerative medicine aims to tackle a panoply of challenges from repairing focal damage to articular cartilage to preventing pathological tissue remodeling after myocardial infarction. Hydrogels are water-swollen networks formed from synthetic or naturally derived polymers and are emerging as important tools to address these challenges. Recent advances in hydrogel chemistries are enabling researchers to create hydrogels that can act as 3D ex vivo tissue models, allowing them to explore fundamental questions in cell biology by replicating tissues' dynamic and nonlinear physical properties...
January 9, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29287161/evaluation-of-equine-synovial-derived-extracellular-matrix-scaffolds-seeded-with-equine-synovial-derived-mesenchymal-stem-cells
#4
Nathalie A Reisbig, Hayam A Hussein, Erin Pinnell, Alicia L Bertone
OBJECTIVE To create a bioactive synovium scaffold by infusing decellularized synovial-derived extracellular matrix (synECM) with synovial-derived mesenchymal stem cells (synMSCs). SAMPLE Synovium from the femoropatellar and medial femorotibial joints of equine cadavers. PROCEDURES The synMSCs were cultured in monolayer and not treated or cotransduced to enhance expression of green fluorescent protein (GFP) and human bone morphogenetic protein (BMP)-2. The synECM was decellularized with 0.1% peracetic acid and then seeded with synMSCs (0...
January 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29250341/results-of-hip-arthroscopy-in-patients-with-mri-diagnosis-of-subchondral-cysts-a-case-series
#5
David E Hartigan, Itay Perets, Leslie C Yuen, Benjamin G Domb
The aim of this article is to examine the results of arthroscopic management of patients with labral pathology who have preoperative magnetic resonance images (MRIs) demonstrating subchondral cysts. This institution's database was searched for patients who underwent hip arthroscopy and had subchondral cysts on MRI and >2-year follow-up. Exclusion criteria included previous hip surgery, Tönnis grade >1, inflammatory arthritis, Perthes, slipped capital femoral epiphysis or abductor repair. Patient-reported outcome (PRO) scores including visual analog scale, modified Harris hip score (mHHS), non-arthritic hip score and hip outcome score sports-specific subscale (HOS-SSS) were gathered preoperatively, at 3 months, and annually thereafter...
December 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29233184/effects-of-angelicae-pubescentis-and-loranthi-decotion-on-repairing-knee-joint-cartilages-in-rats
#6
Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, Junjie Zhou
BACKGROUND: Knee osteoarthritis (KOA) is a common orthopedics disease and its pathological changes at early stage are the damage and loss of articular cartilage. Traditional Chinese medicine (TCM) prescription contains multiple components and has the unique advantages of the diversity of targets.We compared the traditional Chinese medical formulae (Angelicae Pubescentis and Loranthi decotion, APLD, or Duhuo Jisheng) with a western medicine (glucosamine sulfate, GS) to treat the rat arthritis models, and tracked the outcomes...
December 12, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29229249/enzyme-mediated-tissue-adhesive-hydrogels-for-meniscus-repair
#7
Su-Hwan Kim, Young-Hyeon An, Hwan D Kim, Kyungmin Kim, Sang-Hyuk Lee, Hyun-Gu Yim, Byung-Gee Kim, Nathaniel S Hwang
Meniscus tissues have limited regenerative capacity once damaged. The treatment options for the meniscus tissue regeneration have been limited to arthroscopic meniscectomy or surgical interventions. The injectable hydrogels based system would provide an alternative to the conventional meniscus therapy by providing a minimally invasive treatment alternative. Here we utilized enzyme-based approaches to fabricate tissue adhesive hydrogels for meniscus repair. Tyramine (TA) conjugated hyaluronic acid (TA-HA) and gelatin are susceptible to tyrosinase (TYR)-mediated crosslinking in vitro and in vivo...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29215321/mesenchymal-endometrial-stem-stromal-cells-for-hard-tissue-engineering-a-review-of-in-vitro-and-in-vivo-evidence
#8
Fahimeh S Tabatabaei, Jafar Ai
Hard tissues including teeth, bone and cartilage have inability or poor capacity to self-renew, especially in large defects. Therefore, repair of damages in these tissues represents a huge challenge in the medical field today. Hard tissue engineering commonly utilizes different stem cell sources as a promising strategy for treating bone, cartilages and tooth defects or disorders. Decades ago, researchers successfully isolated and identified endometrial mesenchymal stem/stromal cells (EnSCs) and discovered their multidifferentiation potential...
December 7, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29204672/bone-loss-in-rheumatoid-arthritis-basic-mechanisms-and-clinical-implications
#9
REVIEW
Jae-Hyuck Shim, Zheni Stavre, Ellen M Gravallese
Patients with rheumatoid arthritis (RA) have historically developed progressive damage of articular bone and cartilage, which correlates with disability over time. In addition, these patients are prone to periarticular and systemic bone loss, carrying additional morbidity. In contrast to what is seen in many other rheumatic diseases, the impact of inflammation on bone in RA is uniquely destructive. Loss of articular bone (erosions) and periarticular bone (demineralization) is a result of excessive bone resorption and markedly limited bone formation...
December 4, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29178320/low-oxygen-conditions-promote-synergistic-increases-in-chondrogenesis-during-co-culture-of-human-osteoarthritic-stem-cells-and-chondrocytes
#10
Susan E Critchley, Rajalakshmanan Eswaramoorthy, Daniel J Kelly
There has been increased interest in co-cultures of stem cells and chondrocytes for cartilage tissue engineering as there are the limitations associated with using either cell type alone. Drawbacks associated with the use of chondrocytes include the limited numbers of cells available for isolation from damaged or diseased joints, their dedifferentiation during in vitro expansion and a diminished capacity to synthesise cartilage-specific extracellular matrix components with age and disease. This has motivated the use of adult stem cells with either freshly isolated or culture expanded chondrocytes for cartilage repair applications, however the ideal combination of cells and environmental conditions for promoting robust chondrogenesis remains unclear...
November 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29174671/human-igf-i-propeptide-a-promotes-articular-chondrocyte-biosynthesis-and-employs-glycosylation-dependent-heparin-binding
#11
Shuiliang Shi, Brian J Kelly, Congrong Wang, Ken Klingler, Albert Chan, George J Eckert, Stephen B Trippel
BACKGROUND: Insulin-like growth factor I (IGF-I) is a key regulator of chondrogenesis, but its therapeutic application to articular cartilage damage is limited by rapid elimination from the repair site. The human IGF-I gene gives rise to three IGF-I propeptides (proIGF-IA, proIGF-IB and proIGF-IC) that are cleaved to create mature IGF-I. In this study, we elucidate the processing of IGF-I precursors by articular chondrocytes, and test the hypotheses that proIGF-I isoforms bind to heparin and regulate articular chondrocyte biosynthesis...
November 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29169631/functional-mri-can-detect-changes-in-intratissue-strains-in-a-full-thickness-and-critical-sized-ovine-cartilage-defect-model
#12
Deva D Chan, Luyao Cai, Kent D Butz, Eric A Nauman, Darryl A Dickerson, Ilse Jonkers, Corey P Neu
Functional imaging of tissue biomechanics can reveal subtle changes in local softening and stiffening associated with disease or repair, but noninvasive and nondestructive methods to acquire intratissue measures in well-defined animal models are largely lacking. We utilized displacement encoded MRI to measure changes in cartilage deformation following creation of a critical-sized defect in the medial femoral condyle of ovine (sheep) knees, a common in situ and large animal model of tissue damage and repair...
November 20, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29123550/mesenchymal-stem-cells-for-cartilage-regeneration-of-tmj-osteoarthritis
#13
REVIEW
Dixin Cui, Hongyu Li, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng, Yachuan Zhou
Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29118440/native-joint-resident-mesenchymal-stem-cells-for-cartilage-repair-in-osteoarthritis
#14
REVIEW
Dennis McGonagle, Thomas G Baboolal, Elena Jones
The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone marrow-residing haematopoietic stem cells in that they are present in multiple niches in the joint, including subchondral bone, cartilage, synovial fluid, synovium and adipose tissue. Research in experimental models suggests that the migration of MSCs adjacent to the joint cavity is crucial for chonodrogenesis during embryogenesis, and also shows that synovium-derived MSCs might be the primary drivers of cartilage repair in adulthood...
December 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29112467/meniscectomy-and-resultant-articular-cartilage-lesions-of-the-knee-among-prospective-national-football-league-players-an-imaging-and-performance-analysis
#15
Jorge Chahla, Mark E Cinque, Jonathan A Godin, George Sanchez, George F Lebus, James M Whalen, Mark D Price, Nicholas I Kennedy, Gilbert Moatshe, Robert F LaPrade, Matthew T Provencher
BACKGROUND: The effect of prior meniscectomy and the resulting reduction in meniscal tissue on a potential National Football League (NFL) player's articular cartilage status and performance remain poorly elucidated. Purpose/Hypothesis: (1) To determine the epidemiology, imaging characteristics, and associated articular cartilage pathology of the knee among players with a previous meniscectomy who were participating in the NFL Combine and (2) to evaluate the effect of these injuries on performance as compared with matched controls...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29110690/autologous-cell-derived-tissue-engineered-cartilage-for-repairing-articular-cartilage-lesions-in-the-knee-study-protocol-for-a-randomized-controlled-trial
#16
Ning Ma, Hongxia Wang, Xian Xu, Yiqun Wan, Yufeng Liu, Mingjie Wang, Wen Yu, Yongjing Dai, Jiang Peng, Quanyi Guo, Changlong Yu, Shibi Lu
BACKGROUND: Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibrocartilage repair. But fibrocartilage is different from normal articular cartilage, and functional recovery is not satisfactory. Therefore, it is necessary to develop more effective techniques for articular cartilage repair...
November 6, 2017: Trials
https://www.readbyqxmd.com/read/29109026/a-low-friction-biphasic-and-boundary-lubricating-hydrogel-for-cartilage-replacement
#17
Piers E Milner, Maria Parkes, Jennifer L Puetzer, Robert Chapman, Molly M Stevens, Philippa Cann, Jonathan Jeffers
Partial joint repair is a surgical procedure where an artificial material is used to replace localised chondral damage. These artificial bearing surfaces must articulate against cartilage, but current materials do not replicate both the biphasic and boundary lubrication mechanisms of cartilage. A research challenge therefore exists to provide a material that mimics both boundary and biphasic lubrication mechanisms of cartilage. In this work a polymeric network of a biomimetic boundary lubricant, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), was incorporated into an ultra-tough double network (DN) biphasic (water phase + polymer phase) gel, to form a PMPC triple network (PMPC TN) hydrogel with boundary and biphasic lubrication capability...
November 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29106758/transcriptomic-analysis-of-synovial-extracellular-rna-following-knee-trauma-a-pilot-study
#18
Anthony J Griswold, Jose Perez, Karen Nuytemans, Thomas Strong, Liyong Wang, Danica D Vance, Hayley Ennis, Marvin K Smith, Thomas M Best, Jeffery M Vance, Margaret A Pericak-Vance, Lee D Kaplan
Traumatic knee injuries often result in damage to articular cartilage and other joint structures. Such trauma is a strong risk factor for the future development and progression of osteoarthritis (OA). The molecular mechanisms and signaling pathways modulating response to knee joint trauma remain unclear. Moreover, investigations of biomarkers influencing responses have been targeted rather than broad, unbiased discovery studies. Herein we characterize the complete complement of extracellular RNA (exRNA) in the synovial fluid of 14 subjects following knee injury...
November 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29105354/low-oxygen-conditions-promote-synergistic-increases-in-chondrogenesis-during-co-culture-of-human-osteoarthritic-stem-cells-and-chondrocytes
#19
Susan E Critchley, Rajalakshmanan Eswaramoorthy, Daniel J Kelly
There has been increased interest in co-cultures of stem cells and chondrocytes for cartilage tissue engineering as there are the limitations associated with using either cell type alone. Drawbacks associated with the use of chondrocytes include the limited numbers of cells available for isolation from damaged or diseased joints, their dedifferentiation during in vitro expansion and a diminished capacity to synthesise cartilage-specific extracellular matrix components with age and disease. This has motivated the use of adult stem cells with either freshly isolated or culture expanded chondrocytes for cartilage repair applications, however the ideal combination of cells and environmental conditions for promoting robust chondrogenesis remains unclear...
November 3, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29066871/reac-regenerative-treatment-efficacy-in-experimental-chondral-lesions-a-pilot-study-on-ovine-animal-model
#20
Eraldo Sanna Passino, Stefano Rocca, Sabrina Caggiu, Nicolò Columbano, Alessandro Castagna, Vania Fontani, Salvatore Rinaldi
Radioelectric asymmetric conveyor (REAC) technology is a platform designed to optimize cell polarity. Cell polarity is a universal biological phenomenon that is implicated in cell differentiation, proliferation, morphogenesis, aging, and rejuvenation. In this work, we investigate a timing and administration protocol for tissue optimization regenerative treatment type C, in order to treat aging-related chondral damage or injuries and gain insights into regenerative processes of articular cartilage in humans...
2017: Clinical Interventions in Aging
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