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Cartilage repair and damage

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https://www.readbyqxmd.com/read/28210226/combination-of-collagen-based-scaffold-and-bioactive-factors-induces-adipose-derived-mesenchymal-stem-cells-chondrogenic-differentiation-in-vitro
#1
Giovanna Calabrese, Stefano Forte, Rosario Gulino, Francesco Cefalì, Elisa Figallo, Lucia Salvatorelli, Eugenia T Maniscalchi, Giuseppe Angelico, Rosalba Parenti, Massimo Gulisano, Lorenzo Memeo, Raffaella Giuffrida
Recently, multipotent mesenchymal stem cells (MSCs) have attracted much attention in the field of regenerative medicine due to their ability to give rise to different cell types, including chondrocytes. Damaged articular cartilage repair is one of the most challenging issues for regenerative medicine, due to the intrinsic limited capability of cartilage to heal because of its avascular nature. While surgical approaches like chondral autografts and allografts provide symptoms and function improvement only for a short period, MSC based stimulation therapies, like microfracture surgery or autologous matrix-induced chondrogenesis demonstrate to be more effective...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28198149/the-effects-of-using-vitrified-chondrocyte-sheets-on-pain-alleviation-and-articular-cartilage-repair
#2
Yoshiki Tani, Masato Sato, Miki Maehara, Hiroshi Nagashima, Munetaka Yokoyama, Miyuki Yokoyama, Masayuki Yamato, Teruo Okano, Joji Mochida
The effect of using vitrified-thawed chondrocyte sheets on articular cartilage repair was examined because the methods for storing chondrocyte sheets are essential for allogeneic chondrocyte sheet transplantation. Six Japanese white rabbits were used as sources of articular chondrocytes and synovial cells. Chondrocytes were harvested from the femur, and synovial cells were harvested from inside the knee joints. After coculture of the chondrocytes with synovial cells, triple-layered chondrocyte sheets were fabricated...
February 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28193542/sulfated-hyaluronic-acid-hydrogels-with-retarded-degradation-and-enhanced-growth-factor-retention-promote-hmsc-chondrogenesis-and-articular-cartilage-integrity-with-reduced-hypertrophy
#3
Qian Feng, Sien Lin, Kunyu Zhang, Chaoqun Dong, Tianyi Wu, Heqin Huang, Xiaohui Yan, Li Zhang, Gang Li, Liming Bian
: Recently, hyaluronic acid (HA) hydrogels have been extensively researched for delivering cells and drugs to repair damaged tissues, particularly articular cartilage. However, the in vivo degradation of HA is fast, thus limiting the clinical translation of HA hydrogels. Furthermore, HA cannot bind proteins with high affinity because of the lack of negatively charged sulfate groups. In this study, we conjugated sulfate groups to HA. These sulfated HA exhibit significantly slower degradation by hyaluronidase compared to the wild type HA...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28186364/rare-syndromes-of-the-head-and-face-mandibulofacial-and-acrofacial-dysostoses
#4
REVIEW
Karla Terrazas, Jill Dixon, Paul A Trainor, Michael J Dixon
Craniofacial anomalies account for approximately one-third of all congenital birth defects reflecting the complexity of head and facial development. Craniofacial development is dependent upon a multipotent, migratory population of neural crest cells, which generate most of the bone and cartilage of the head and face. In this review, we discuss advances in our understanding of the pathogenesis of a specific array of craniofacial anomalies, termed facial dysostoses, which can be subdivided into mandibulofacial dysostosis, which present with craniofacial defects only, and acrofacial dysostosis, which encompasses both craniofacial and limb anomalies...
February 10, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28183011/semi-degradable-porous-poly-vinyl-alcohol-hydrogel-scaffold-for-cartilage-repair-evaluation-of-the-initial-and-cell-cultured-tribological-properties
#5
Yi Cao, Dangsheng Xiong, Kun Wang, Yuxiang Niu
Tissue engineering for articular cartilage repair has shown success in ensuring the integration of neocartilage with surrounding tissue, but the rapid restoration of biomechanical and biotribological functions remains a significant challenge. Poly (vinyl alcohol) (PVA) hydrogel is regarded as a potential articular cartilage replacement for its fair mechanical strength and low surface friction, while its lack of bioactivity limits its utility. Combining the advantages of tissue engineering materials and PVA hydrogel, we developed a semi-degradable porous PVA hydrogel through addition of ploy (lactic-co-glycolic acid) (PLGA) microspheres and salt-leaching technique...
February 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28176272/effects-of-combined-raav-mediated-tgf-%C3%AE-and-sox9-gene-transfer-and-overexpression-on-the-metabolic-and-chondrogenic-activities-in-human-bone-marrow-aspirates
#6
Ke Tao, Ana Rey-Rico, Janina Frisch, Jagadeesh Kumar Venkatesan, Gertrud Schmitt, Henning Madry, Jianhao Lin, Magali Cucchiarini
BACKGROUND: Transplantation of genetically modified bone marrow concentrates is an attractive approach to conveniently activate the chondrogenic differentiation processes as a means to improve the intrinsic repair capacities of damaged articular cartilage. METHODS: Human bone marrow aspirates were co-transduced with recombinant adeno-associated virus (rAAV) vectors to overexpress the pleiotropic transformation growth factor beta (TGF-β) and the cartilage-specific transcription factor sox9 as a means to enhance the chondroreparative processes in conditions of specific lineage differentiation...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28169453/mechanical-properties-and-structure-function-relationships-of-human-chondrocyte-seeded-cartilage-constructs-after-in-vitro-culture
#7
Jill M Middendorf, Darvin J Griffin, Sonya Shortkroff, Caroline Dugopolski, Stephen Kennedy, Joseph Siemiatkoski, Itai Cohen, Lawrence J Bonassar
Autologous Chondrocyte Implantation (ACI) is a widely recognized method for the repair of focal cartilage defects. Despite the accepted use, problems with this technique still exist, including graft hypertrophy, damage to surrounding tissue by sutures, uneven cell distribution, and delamination. Modified ACI techniques overcome these challenges by seeding autologous chondrocytes onto a 3D scaffold and securing the graft into the defect. Many studies on these tissue engineered grafts have identified the compressive properties, but few have examined frictional and shear properties as suggested by FDA guidance...
February 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28149716/hip-arthroscopy-for-removal-of-an-acetabular-rim-based-osteoid-osteoma-and-concomitant-femoroacetabular-impingement-correction
#8
Jacques A Denker, Hollis M Fritts, Rebecca M Stone, Christopher M Larson
Minimally invasive percutaneous radiofrequency ablation (RFA) techniques are the standard of care for treating simple osteoid osteomas (OOs). Historically, OOs were treated with open en bloc resection or curettage of the nidus. RFA procedures have been linked to soft-tissue complications of varying severity. In addition, RFA may be a poor choice for periarticular OOs because of the potential for procedure-related articular cartilage damage. Hip arthroscopy is a widely accepted approach for the treatment of femoroacetabular impingement...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28138955/recent-advances-in-hydrogels-for-cartilage-tissue-engineering
#9
S L Vega, M Y Kwon, J A Burdick
Articular cartilage is a load-bearing tissue that lines the surface of bones in diarthrodial joints. Unfortunately, this avascular tissue has a limited capacity for intrinsic repair. Treatment options for articular cartilage defects include microfracture and arthroplasty; however, these strategies fail to generate tissue that adequately restores damaged cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue...
January 30, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28129782/cord-blood-cell-derived-ipscs-as-a-new-candidate-for-chondrogenic-differentiation-and-cartilage-regeneration
#10
Yoojun Nam, Yeri Alice Rim, Seung Min Jung, Ji Hyeon Ju
BACKGROUND: The native articular cartilage lacks the ability to heal. Currently, ex vivo expanded chondrocytes or bone marrow-derived mesenchymal stem cells are used to regenerate the damaged cartilage. With unlimited self-renewal ability and multipotency, human induced pluripotent stem cells (hiPSCs) have been highlighted as a new replacement cell source for cartilage repair. Still, further research is needed on cartilage regeneration using cord blood mononuclear cell-derived hiPSCs (CBMC-hiPSCs)...
January 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28103756/compression-induced-chondrogenic-differentiation-of-embryonic-stem-cells-in-3-d-pdms-scaffolds
#11
Christina McKee, Yifeng Hong, Donggang Yao, G Rasul Chaudhry
Embryonic stem cells (ESCs) are an ideal source for chondrogenic progenitors for the repair of damaged cartilage tissue. It is currently difficult to induce uniform and scalable ESC differentiation in vitro, a process required for stem cell therapy. This is partly because stem cell fate is determined by complex interactions with the native microenvironment and mechanical properties of the extracellular matrix. Mechanical signaling is considered to be one of the major factors regulating the proliferation and differentiation of chondrogenic cells both in vitro and in vivo...
January 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28088667/cell-laden-hydrogels-for-osteochondral-and-cartilage-tissue-engineering
#12
REVIEW
Jingzhou Yang, Yu Shrike Zhang, Kan Yue, Ali Khademhosseini
: Despite tremendous advances in the field of regenerative medicine, it still remains challenging to repair the osteochondral interface and full-thickness articular cartilage defects. This inefficiency largely originates from the lack of appropriate tissue engineered artificial matrices that can replace the damaged regions and promote tissue regeneration. Hydrogels are emerging as a promising class of biomaterials for both soft and hard tissue regeneration. Many critical properties of hydrogels, such as mechanical stiffness, elasticity, water content, bioactivity, and degradation, can be rationally designed and conveniently tuned by proper selection of the material and chemistry...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28075154/survivorship-after-meniscal-allograft-transplantation-according-to-articular-cartilage-status
#13
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Won-Kyeong Kim, Jun Weon Choi
BACKGROUND: Clinical outcomes after meniscal allograft transplantation (MAT) in arthritic knees are unclear, and objective estimates of graft survival according to the articular cartilage status have not been performed. HYPOTHESIS: MAT should provide clinical benefits in knees with high-grade cartilage damage, but their graft survivorship should be inferior to that in knees with low-grade chondral degeneration after MAT. STUDY DESIGN: Cohort study; Level of evidence, 3...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28041611/the-mechanics-of-focal-chondral-defects-in-the-hip
#14
Brenden J Klennert, Benjamin J Ellis, Travis G Maak, Ashley L Kapron, Jeffrey A Weiss
There is a mean incidence of osteoarthritis (OA) of the hip in 8% of the overall population. In the presence of focal chondral defects, defined as localized damage to the articular cartilage, there is an increased risk of symptomatic progression toward OA. This relationship between chondral defects and subsequent development of OA has led to substantial efforts to develop effective procedures for surgical cartilage repair. This study examined the effects of chondral defects and labral delamination on cartilage mechanics in the dysplastic hip during the gait cycle using subject-specific finite element analysis...
November 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28040083/a-novel-aragonite-based-scaffold-for-osteochondral-regeneration-early-experience-on-human-implants-and-technical-developments
#15
Elizaveta Kon, Dror Robinson, Peter Verdonk, Matej Drobnic, Jenel Mariano Patrascu, Oliver Dulic, Gordon Gavrilovic, Giuseppe Filardo
INTRODUCTION: Chondral and osteochondral lesions represent a debilitating disease. Untreated lesions remain a risk factor for more extensive joint damage. The objective of this clinical study is to evaluate safety and early results of an aragonite-based scaffold used for osteochondral unit repair, by analysing both clinical outcome and MRI results, as well as the benefits of the procedure optimization through novel tapered shaped implants. METHODS: A crystalline aragonite bi-phasic scaffold was implanted in patients affected by focal chondral-osteochondral knee lesions of the condyle and trochlea...
December 2016: Injury
https://www.readbyqxmd.com/read/28007307/human-based-biological-and-biomimetic-autologous-therapies-for-musculoskeletal-tissue-regeneration
#16
REVIEW
Sabino Padilla, Mikel Sánchez, Gorka Orive, Eduardo Anitua
Repairing and regenerating damaged musculoskeletal tissues is one of the greatest challenges in regenerative medicine. Blood contains the essential ingredients to biologically engineer drug delivery devices that provide spatiotemporal control over the availability of a wide range of autologous agents, including small molecules, cytokines, and growth factors. This opinion article summarizes our current knowledge of blood-derived biological drug delivery therapies. The potential mechanisms that control protein release are discussed, along with the biological rationale and effects of their use in different relevant musculoskeletal tissues, including articular cartilage, bone, tendon, muscle, and nerve tissue injuries...
December 19, 2016: Trends in Biotechnology
https://www.readbyqxmd.com/read/28002904/the-meniscus-vascularization-the-direct-correlation-with-tissue-composition-for-tissue-engineering-purposes
#17
A Di Giancamillo, L Mangiavini, I Tessaro, A Marmotti, R Scurati, G M Peretti
Meniscal lesions still represent an unsolved problem in clinical practice. Like the articular cartilage, meniscus has a scarce healing potential. Thus, when this tissue is damaged, the joint biomechanics is completely altered, leading to the development and progression of premature osteoarthritis. Therefore, in the last years, several tissue-engineering strategies have been developed to regenerate the meniscus with debated results. The comprehension of complex processes underlying meniscus maturation and structure is essential for a correct approach for the generation of a biomimetic meniscal substitute...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27993154/efficacy-and-safety-of-adult-human-bone-marrow-derived-cultured-pooled-allogeneic-mesenchymal-stromal-cells-stempeucel%C3%A2-preclinical-and-clinical-trial-in-osteoarthritis-of-the-knee-joint
#18
Pawan Kumar Gupta, Anoop Chullikana, Mathiyazhagan Rengasamy, Naresh Shetty, Vivek Pandey, Vikas Agarwal, Shrikant Yeshwant Wagh, Prasanth Kulapurathu Vellotare, Devi Damodaran, Pachaiyappan Viswanathan, Charan Thej, Sudha Balasubramanian, Anish Sen Majumdar
BACKGROUND: Osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the joints. Currently, cell-based therapy is being explored to address the repair of damaged articular cartilage in the knee joint. METHODS: The in vitro differentiation potential of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®) was determined by differentiating the cells toward the chondrogenic lineage and quantifying sulfated glycosaminoglycan (sGAG)...
December 20, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27982693/long-noncoding-rna-dancr-is-a-positive-regulator-of-proliferation-and-chondrogenic-differentiation-in-human-synovium-derived-stem-cells
#19
Lei Zhang, Chao Yang, Shuo Chen, Guihua Wang, Ben Shi, Xin Tao, Liwu Zhou, Jianning Zhao
Cartilage tissues have limited capacity for repair after damage and then cause osteoarthritis, so finding alternative treatment is ongoing. Mesenchymal stem cells (MSCs) have become a promising therapy for cartilage damage and diseases due to the advantages of easy separation, high proliferative potentiality, and genetic stability. Synovium-derived MSCs (SMSCs) have been recognized as an ideal source for cartilage repair. In our previous study, we found that Sox4 promoted proliferation and chondrogenesis of SMSCs through upregulation of long noncoding RNA (lncRNA) DANCR...
February 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/27941390/mesenchymal-stem-cells-for-the-management-of-rheumatoid-arthritis-immune-modulation-repair-or-both
#20
Sharon Ansboro, Anke J Roelofs, Cosimo De Bari
PURPOSE OF REVIEW: Mesenchymal stromal/stem cells (MSCs) have potent anti-inflammatory and immunomodulatory properties, in addition to their ability to form cartilage and bone. The purpose of this review is to highlight recent developments and current knowledge gaps in our understanding of the protective effects of MSCs against inflammatory arthritis, and to discuss their clinical exploitation for the treatment of rheumatoid arthritis (RA). RECENT FINDINGS: The weight of evidence for protective mechanisms of exogenously administered MSCs is on immunomodulatory effects, including inhibition of dendritic cell maturation, polarization of macrophages to an anti-inflammatory phenotype, and activation of regulatory T cells, thereby dampening inflammation and preventing joint damage...
March 2017: Current Opinion in Rheumatology
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