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https://www.readbyqxmd.com/read/29332075/patient-evaluation-and-selection-for-movement-disorders-surgery-the-changing-spectrum-of-indications
#1
Steffen Paschen, Günther Deuschl
This report summarizes the state-of-the-art and controversies around patient selection for deep brain stimulation (DBS) for various conditions. Parkinson's disease (PD): several class I studies have shown superiority of DBS over best medical treatment for advanced PD with fluctuations and further inclusion criteria. One class I study suggests that PD patients with early motor complications might gain more quality of life if operated within 3 years after the onset of fluctuations. The subthalamic nucleus (STN) is still the standard target...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29316056/rechargeable-internal-pulse-generators-as-initial-neurostimulators-for-deep-brain-stimulation-in-patients-with-movement-disorders
#2
Martin Jakobs, Manja Kloß, Andreas Unterberg, Karl Kiening
INTRODUCTION: Rechargeable internal pulse generators (r-IPGs) for deep brain stimulation (DBS) promise a longer battery life and cost effectiveness compared to non-rechargeable IPGs. However, patients need to learn to check the battery capacity and perform the recharging process to ensure continuous therapy. METHODS: n = 35 consecutive adult patients with movement disorders that underwent DBS electrode placement with implantation of a r-IPG were assessed with a questionnaire...
January 8, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29314231/anorexia-nervosa-and-uric-acid-beyond-gout-an-idea-worth-researching
#3
Mladena Simeunovic Ostojic, Joyce Maas
Uric acid is best known for its role in gout-the most prevalent inflammatory arthritis in humans-that is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro- and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns...
January 4, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29308739/neurostimulation-in-clinical-and-sub-clinical-eating-disorders-a-systematic-update-of-the-literature
#4
Bethan Dalton, Savani Bartholdy, Iain C Campbell, Ulrike Schmidt
INTRODUCTION: Whilst psychological therapies are the main approach to treatment of eating disorders (EDs), advances in aetiological research suggest the need for the development of more targeted, brain-focused treatments. A range of neurostimulation approaches, most prominently repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (DBS), are rapidly emerging as potential novel interventions. We have previously reviewed these techniques as potential treatments of EDs...
January 7, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29307607/subthalamic-stimulation-oscillatory-activity-and-connectivity-reveal-functional-role-of-stn-and-network-mechanisms-during-decision-making-under-conflict
#5
Franz Hell, Paul C J Taylor, Jan H Mehrkens, Kai Bötzel
Inhibitory control is an important executive function that is necessary to suppress premature actions and to block interference from irrelevant stimuli. Current experimental studies and models highlight proactive and reactive mechanisms and claim several cortical and subcortical structures to be involved in response inhibition. However, the involved structures, network mechanisms and the behavioral relevance of the underlying neural activity remain debated. We report cortical EEG and invasive subthalamic local field potential recordings from a fully implanted sensing neurostimulator in Parkinson's patients during a stimulus- and response conflict task with and without deep brain stimulation (DBS)...
January 4, 2018: NeuroImage
https://www.readbyqxmd.com/read/29286422/methodology-for-biomimetic-chemical-neuromodulation-of-rat-retinas-with-the-neurotransmitter-glutamate-in-vitro
#6
Corey M Rountree, John B Troy, Laxman Saggere
Photoreceptor degenerative diseases cause irreparable blindness through the progressive loss of photoreceptor cells in the retina. Retinal prostheses are an emerging treatment for photoreceptor degenerative diseases that seek to restore vision by artificially stimulating the surviving retinal neurons in the hope of eliciting comprehensible visual perception in patients. Current retinal prostheses have demonstrated success in restoring limited vision to patients using an array of electrodes to electrically stimulate the retina but face substantial physical barriers in restoring high acuity, natural vision to patients...
December 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29285576/sphenopalatine-ganglion-block-radiofrequency-ablation-and-neurostimulation-%C3%A2-a-systematic-review
#7
REVIEW
Kwo Wei David Ho, Rene Przkora, Sanjeev Kumar
BACKGROUND: Sphenopalatine ganglion is the largest collection of neurons in the calvarium outside of the brain. Over the past century, it has been a target for interventional treatment of head and facial pain due to its ease of access. Block, radiofrequency ablation, and neurostimulation have all been applied to treat a myriad of painful syndromes. Despite the routine use of these interventions, the literature supporting their use has not been systematically summarized. This systematic review aims to collect and summarize the level of evidence supporting the use of sphenopalatine ganglion block, radiofrequency ablation and neurostimulation...
December 28, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29248528/feasibility-safety-and-efficacy-of-subcutaneous-peripheral-nerve-field-stimulation-for-the-treatment-of-refractory-low-back-pain-a-two-year-single-center-study
#8
Basem Ishak, Benito Campos, Heike Brunn, Andreas W Unterberg, Rezvan Ahmadi
Chronic low back pain is challenging to treat. Minimal invasive neurostimulation therapies, such as subcutaneous peripheral nerve field stimulation (SPNS), improve pain relief and quality of life,. The goal of the present study was to assess the usefulness, safety, and efficacy of SPNS in patients with chronic low back pain (CLBP). Twenty-six consecutive patients with CLBP were prospectively included in the study. For trial neurostimulation, two electrodes were implanted vertically at a depth of 1 cm into the subcutaneous tissue, ≤ 10 cm from the region of maximum pain...
December 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/29247796/theta-burst-modulation-of-mid-ventrolateral-prefrontal-cortex-affects-salience-coding-in-the-human-ventral-tegmental-area
#9
Martin Ulrich, Sabrina Lorenz, Markus W Spitzer, Leon Steigleder, Thomas Kammer, Georg Grön
In the context of hedonic (over-)eating the ventral tegmental area (VTA) as a core part of the dopaminergic reward system plays a central role in coding incentive salience of high-caloric food. In the present study, we used functional magnetic resonance imaging (fMRI) to investigate whether transcranial magnetic theta-burst stimulation (TBS) over the right mid-ventrolateral prefrontal cortex (mid-VLPFC) can induce modulation of calorie-sensitive brain activation in the VTA. The prefrontal location for TBS had been predetermined by seed-based resting-state fMRI with a functionally defined portion of the VTA serving as seed region obtained from an independent second fMRI experiment...
December 13, 2017: Appetite
https://www.readbyqxmd.com/read/29244235/new-therapy-for-refractory-chronic-mechanical-low-back-pain-restorative-neurostimulation-to-activate-the-lumbar-multifidus-one-year-results-of-a-prospective-multicenter-clinical-trial
#10
REVIEW
Kristiaan Deckers, Kris De Smedt, Bruce Mitchell, David Vivian, Marc Russo, Peter Georgius, Matthew Green, John Vieceli, Sam Eldabe, Ashish Gulve, Jean-Pierre van Buyten, Iris Smet, Vivek Mehta, Shankar Ramaswamy, Ganesan Baranidharan, Richard Sullivan, Robert Gassin, James Rathmell, Chris Gilligan
OBJECTIVES: The purpose of the international multicenter prospective single arm clinical trial was to evaluate restorative neurostimulation eliciting episodic contraction of the lumbar multifidus for treatment of chronic mechanical low back pain (CMLBP) in patients who have failed conventional therapy and are not candidates for surgery or spinal cord stimulation (SCS). MATERIALS AND METHODS: Fifty-three subjects were implanted with a neurostimulator (ReActiv8, Mainstay Medical Limited, Dublin, Ireland)...
December 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29244138/long-term-results-of-responsive-neurostimulation-in-different-seizure-onset-locations
#11
Nathaniel D Sisterson, R Mark Richardson
No abstract text is available yet for this article.
January 1, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29235453/potential-impact-of-thermal-effects-during-ultrasonic-neurostimulation-retrospective-numerical-estimation-of-temperature-elevation-in-seven-rodent-setups
#12
Charlotte Constans, Philippe Mateo, Mickael Tanter, Jean-Francois Aubry
In the past decade, a handful but growing number of groups have reported worldwide successful low intensity focused ultrasound induced neurostimulation trials on rodents with effects ranging from movement elicitations to reduction of anesthesia time or reduction of the duration of drug induced seizures. The mechanisms underlying ultrasonic neuromodulation are still not fully understood. Given the low intensities used in most of the studies, a mechanical effect is more likely to be responsible for the neuromodulation effect, but a clear description of the thermal and mechanical effects is necessary to optimize clinical applications...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29230905/muscle-control-and-non-specific-chronic-low-back-pain
#13
REVIEW
Marc Russo, Kristiaan Deckers, Sam Eldabe, Kyle Kiesel, Chris Gilligan, John Vieceli, Peter Crosby
OBJECTIVES: Chronic low back pain (CLBP) is the most prevalent of the painful musculoskeletal conditions. CLBP is a heterogeneous condition with many causes and diagnoses, but there are few established therapies with strong evidence of effectiveness (or cost effectiveness). CLBP for which it is not possible to identify any specific cause is often referred to as non-specific chronic LBP (NSCLBP). One type of NSCLBP is continuing and recurrent primarily nociceptive CLBP due to vertebral joint overload subsequent to functional instability of the lumbar spine...
December 12, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29230247/wireless-neuromodulation-for-chronic-back-pain-delivery-of-high-frequency-dorsal-root-ganglion-stimulation-by-a-minimally-invasive-technique
#14
Bart Billet, Roel Wynendaele, Niek E Vanquathem
Objective: To evaluate the analgesic effect of a dorsal root ganglion (DRG) stimulation technology utilizing high-frequency pulse rates to treat intractable chronic back and leg pain. Methods: This case study presents the outcomes, with a novel, wireless, minimally invasive miniature neurostimulator system in a case of chronic back pain. The subject was implanted bilaterally with a Freedom 4A quadripolar electrode array at the L2 dorsal root ganglion. Stimulation was applied using 10 kHz pulse rate and 30 μs pulse width...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/29221942/neurostimulant-use-is-associated-with-improved-survival-in-comatose-patients-after-cardiac-arrest-regardless-of-electroencephalographic-substrate
#15
Alexis Steinberg, Jon C Rittenberger, Maria Baldwin, John Faro, Alexandra Urban, Naoir Zaher, Clifton W Callaway, Jonathan Elmer
AIM: Identify EEG patterns that predict or preclude favorable response in comatose post-arrest patients receiving neurostimulants. METHODS: We examined a retrospective cohort of consecutive electroencephalography (EEG)-monitored comatose post-arrest patients. We classified the last day of EEG recording before neurostimulant administration based on continuity (continuous/discontinuous), reactivity (yes/no) and malignant patterns (periodic discharges, suppression burst, myoclonic status epilepticus or seizures; yes/no)...
December 5, 2017: Resuscitation
https://www.readbyqxmd.com/read/29221791/online-effects-of-transcranial-direct-current-stimulation-on-prefrontal-metabolites-in-gambling-disorder
#16
Maya Dickler, Christophe Lenglos, Emmanuelle Renauld, Francine Ferland, Richard A Edden, Jean Leblond, Shirley Fecteau
Gambling disorder is characterized by persistent maladaptive gambling behaviors and is now considered among substance-related and addictive disorders. There is still unmet therapeutic need for these clinical populations, however recent advances indicate that interventions targeting the Glutamatergic/GABAergic system hold promise in reducing symptoms in substance-related and addictive disorders, including gambling disorder. There is some data indicating that transcranial direct current stimulation may hold clinical benefits in substance use disorders and modulate levels of brain metabolites including glutamate and GABA...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29214634/a-case-of-hypoglossal-nerve-stimulator-resistant-obstructive-sleep-apnea-cured-with-the-addition-of-a-chin-strap
#17
Apoorva T Ramaswamy, Carol Li, Maria V Suurna
A population of appropriately selected patients does not respond, or does not achieve cure, with hypoglossal nerve stimulation (HGNS). We describe the case of nonresponder whose obstructive sleep apnea (OSA) resolved with the addition of chin strap. After initial placement and titration of HGNS implant, follow-up sleep study demonstrated persistent moderate OSA. Drug-induced sleep endoscopy demonstrated supraglottic collapse with activate neurostimulation. With mouth closure and change of stimulation settings to unipolar from bipolar, the airway collapse and desaturations improved...
December 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29213283/lateral-supratrochanteric-approach-to-sciatic-and-femoral-nerve-blocks-in-children-a-feasibility-study
#18
Andrew A Albokrinov, Ulbolhan A Fesenko, Taras B Huz, Valentyna M Perova-Sharonova
Background: Sciatic and femoral nerve blocks (SNB and FNB) result in effective lower limb analgesia. Classical SNB and FNB require patient repositioning which can cause pain and discomfort. Alternative approaches to sciatic and femoral nerve blocks in supine patients can be useful. Materials and Methods: Neurostimulator-guided SNB and FNB from the lateral supratrochanteric approach were performed. Local anesthetic spread in SNB and FNB after radiographic opacification was analyzed...
2017: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29208618/feasibility-study-of-a-randomised-controlled-trial-to-investigate-the-treatment-of-sarcoidosis-associated-fatigue-with-methylphenidate-fast-mp-a-study-protocol
#19
Christopher Atkins, Richard Fordham, Allan B Clark, Andrea Stockl, Andrew P Jones, Andrew M Wilson
INTRODUCTION: Fatigue is a frequent and troublesome manifestation of chronic sarcoidosis. This symptom can be debilitating and difficult to treat, with poor response to the treatment. Symptomatic management with neurostimulants, such as methylphenidate, is a possible treatment option. The use of such treatment strategies is not without precedent and has been trialled in cancer-related fatigue. Their use in sarcoidosis requires further evaluation before it can be recommended for clinical practice...
December 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29202131/multifunctional-system-for-observing-measuring-and-analyzing-stimulation-evoked-neurochemical-signaling
#20
Christopher J Kimble, Joshua B Boesche, Diane R Eaker, Kenneth R Kressin, James K Trevathan, Seungleal Paek, Anders J Asp, Malcolm B McIntosh, J Luis Lujan
The ability to measure neurotransmitter activity using implanted electrochemical sensors offers researchers a potent technique for analyzing neural activity across specific neural circuitry. We have developed a wirelessly controlled device, WINCS Harmoni, to observe and measure neurotransmitter dynamics at up to four separate sensors, with high temporal and spatial resolution. WINCS Harmoni also incorporates a versatile neurostimulator that can be synchronized with electrochemical recording. The WINCS Harmoni platform is thus optimally suited for probing the neurochemical effects of neurostimulation, and may in turn enable the development of personalized therapies for multiple brain disorders...
May 2017: IEEE International Symposium on Medical Measurements and Applications: Proceedings
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