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https://www.readbyqxmd.com/read/29144821/pyramidal-lobe-remnant
#1
Jamila A Benmoussa, Hassan Shawa
No abstract text is available yet for this article.
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144549/zuclopenthixol-dihydrochloride-for-schizophrenia
#2
REVIEW
Edward J Bryan, Marie Ann Purcell, Ajit Kumar
BACKGROUND: Oral zuclopenthixol dihydrochloride (Clopixol) is an anti-psychotic treatment for people with psychotic symptoms, especially those with schizophrenia. It is associated with neuroleptic malignant syndrome, a prolongation of the QTc interval, extra-pyramidal reactions, venous thromboembolism and may modify insulin and glucose responses. OBJECTIVES: To determine the effects of zuclopenthixol dihydrochloride for treatment of schizophrenia. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Trials Register (latest search 09 June 2015)...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29144131/twisting-and-tilting-1-1-bis-dialkylphosphino-ferrocene-bound-to-low-valent-tricarbonylmaganese-i-to-i
#3
K Michael Schäfer, Leonie Reinders, Jan Fiedler, Mark R Ringenberg
Recently we had reported the noninnocent behavior of 1,1'-bis(diphenylphosphino)ferrocene (dppf) in Fe(CO)3dppf [Ringenberg et al., Inorg. Chem., 2017, 56, 7501]. Moving to the left in the periodic table, HMn(CO)3(dRpf) where dRpf = dppf (1H) and 1,1'-bis(diisopropylphosphino)ferrocene (dippf) (2H) were synthesized. The hydride ligand was removed by protonation with [(Et2O)2H][B(Ar(F))4] ([B(Ar(F))4](-) = tetrakis[3,5-bis(trifluoromethyl)phenyl]borate), resulting in the rapid evolution of H2 followed by the formation of an Fe→Mn interaction...
November 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29143178/transgenic-cotton-co-expressing-chimeric-vip3acaa-and-cry1ac-confers-effective-protection-against-cry1ac-resistant-cotton-bollworm
#4
Wen-Bo Chen, Guo-Qing Lu, Hong-Mei Cheng, Chen-Xi Liu, Yu-Tao Xiao, Chao Xu, Zhi-Cheng Shen, Mario Soberón, Alejandra Bravo, Kong-Ming Wu
Wide planting of transgenic Bt cotton in China since 1997 to control cotton bollworm (Helicoverpa armigera) has increased yields and decreased insecticide use, but the evolution of resistance to Bt cotton by H. armigera remains a challenge. Toward developing a new generation of insect-resistant transgenic crops, a chimeric protein of Vip3Aa1 and Vip3Ac1, named Vip3AcAa, having a broader insecticidal spectrum, was specifically created previously in our laboratory. In this study, we investigated cross resistance and interactions between Vip3AcAa and Cry1Ac with three H...
November 15, 2017: Transgenic Research
https://www.readbyqxmd.com/read/29143059/short-lived-intermediates-in-photochemistry-of-an-oscl6-2-complex-in-aqueous-solutions
#5
Marina V Rogozina, Vladislav V Yudanov, Roman G Fedunov, Ivan P Pozdnyakov, Alexey A Melnikov, Sergey V Chekalin, Evgeni M Glebov
Two mechanisms of Os(IV)Cl6(2-) photolysis were studied by means of quantum chemical calculations in gas and aqueous phases. The difference between these mechanisms is in the nature of the possible Os(iv) key intermediates (KI). According to calculations, the intermediate is an Os(IV)Cl5(-) complex of square pyramidal coordination geometry. The calculations do not give an opportunity to make an unambiguous choice between the triplet and quintet multiplicities of Os(IV)Cl5(-). The calculated CASSCF/IMCP-SR1 transition energies for (5)Os(IV)Cl5(-) are lower than for (3)Os(IV)Cl5(-), while the calculated XMC-QDPT2/SBKJC spectra for the triplet state are in better agreement with the experimental absorption spectrum of the KI than for the quintet state...
November 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29142416/protective-effect-of-pluchea-lanceolata-against-aluminum-chloride-induced-neurotoxicity-in-swiss-albino-mice
#6
Ravi Mundugaru, Senthilkumar Sivanesan, Padmaja Udaykumar, Niranjan Rao, Naveen Chandra
Background: Aluminum chloride (AlCl3) is a known potent environmental neurotoxin causing progressive neurodegenerative changes in the brain. The herb Pluchea lanceolata is commonly known as "Rasana" and used as a nerve tonic in neuroinflammatory conditions in Indian system of medicine. Objective: To evaluate the neuroprotective activity of hydroalcoholic extract of P. lanceolata in chronic AlCl3-induced neurotoxicity in Swiss albino mice. Materials and Methods: Albino mice were categorized into four different groups; Group 1served as vehicle control, Group 2 mice were administered with AlCl3, 40 mg/kg body weight by intraperitoneal route for 45 consecutive days...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142096/novel-ca-2-dependent-mechanisms-regulate-spontaneous-release-at-excitatory-synapses-onto-ca1-pyramidal-cells
#7
Walter E Babiec, Thomas J O'Dell
Although long thought to simply be a source of synaptic noise, spontaneous, action-potential independent release of neurotransmitter from presynaptic terminals has multiple roles in synaptic function. We explored whether and to what extent the two predominantly proposed mechanisms for explaining spontaneous release, stochastic activation of voltage-gated Ca(2+) channels (VGCCs) or activation of Ca(2+)-sensing receptors (CaSRs) by extracelluar Ca(2+), played a role in the sensitivity of spontaneous release to the level of extracellular Ca(2+) concentration at excitatory synapses at CA1 pyramidal cells of the adult, male mouse hippocampus...
November 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29141795/validity-and-reliability-of-the-international-cooperative-ataxia-rating-scale-icars-and-the-scale-for-the-assessment-and-rating-of-ataxia-sara-in-multiple-sclerosis-patients-with-ataxia
#8
Yeliz Salcı, Ayla Fil, Hilal Keklicek, Barış Çetin, Kadriye Armutlu, Anıl Dolgun, Aslı Tuncer, Rana Karabudak
BACKGROUND: Ataxia is an extremely common problem in multiple sclerosis (MS) patients. Thus, appropriate scales are required for detailed assessment of this issue. The aim of our study was to investigate the reliability and validity of the Turkish version of the International Cooperative Ataxia Rating Scale (ICARS) and Scale for the Assessment and Rating of Ataxia (SARA), which are widely used in ataxia evaluation in the context of other cerebellar diseases. METHOD: This cross-sectional study included 80 MS patients with Kurtzke cerebellar functional system score (C-FSS) greater than zero and slight pyramidal involvement...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141794/short-term-outcome-of-adem-results-from-a-retrospective-cohort-study-from-south-india
#9
Mary Iype, P A Mohammed Kunju, Geetha Saradakutty, T S Anish, Mini Sreedharan, Shahanaz M Ahamed
INTRODUCTION: Acute disseminated encephalomyelitis (ADEM), an immune mediated inflammatory disease is common in children. The profile and immediate outcome of children hospitalized with ADEM is scarce in the available literature. OBJECTIVES: We aimed to study the clinical profile of children with ADEM and to look for prognostic factors for outcome at discharge from hospital METHODS: We chose a retrospective cohort study of all children diagnosed with ADEM at our institution between January 2006 and December 2015, and they were evaluated, after excluding other diagnoses when they were summoned for a follow up visit...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29140973/a-coupled-oscillator-model-of-olfactory-bulb-gamma-oscillations
#10
Guoshi Li, Thomas A Cleland
The olfactory bulb transforms not only the information content of the primary sensory representation, but also its underlying coding metric. High-variance, slow-timescale primary odor representations are transformed by bulbar circuitry into secondary representations based on principal neuron spike patterns that are tightly regulated in time. This emergent fast timescale for signaling is reflected in gamma-band local field potentials, presumably serving to efficiently integrate olfactory sensory information into the temporally regulated information networks of the central nervous system...
November 15, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29140692/synthesis-of-surface-analogue-square-planar-tetranuclear-nickel-hydride-clusters-and-bonding-to-%C3%AE-4-nr-o-and-bh-ligands
#11
Manar M Shoshani, Robert Beck, Xiaoping Wang, Matthew J McLaughlin, Samuel A Johnson
Tetranuclear Ni complexes were synthesized with bonding to BH, NR, and O in atypical surface-like geometries. The previously reported electron-deficient cluster [((i)Pr3P)Ni]5H6 (1) reacts with N-methylmorpholine oxide to give [((i)Pr3P)Ni]4H4(μ4-O) (2), which contains O coordinated in the center of a square-plane arrangement of Ni atoms. Reaction of 1 with benzonitrile gave the square-planar tetranuclear Ni cluster [((i)Pr3P)Ni]4H4(μ4-NCH2Ph) (3), which contains an imido donor in a square-based-pyramidal geometry...
November 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29140589/simple-access-to-the-heaviest-alkaline-earth-metal-hydride-a-strongly-reducing-hydrocarbon-soluble-barium-hydride-cluster
#12
Sjoerd Harder, Brant Maitland, Michael Wiesinger, Christian Färber, Gerd Ballmann, Holger Elsen, Christian Fischer
Reaction of Ba[N(SiMe3)2]2 with PhSiH3 in toluene gave simple access to the unique Ba hydride cluster Ba7H7[N(SiMe3)2]7 that can be described as a square pyramide spanned by five Ba2+ ions with two flanking BaH[N(SiMe3)2] units. This heptanuclear cluster is well soluble in aromatic solvents and the hydride 1H NMR signals and coupling pattern suggests that the structure is stable in solution. At 95 °C, no coalescence of hydride signals is observed but the cluster slowly decomposes to undefined Ba hydride species...
November 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29138490/bidirectional-modulation-of-hippocampal-synaptic-plasticity-by-dopaminergic-d4-receptors-in-the-ca1-area-of-hippocampus
#13
Sheeja Navakkode, Katherine C M Chew, Sabrina Jia Ning Tay, Qingshu Lin, Thomas Behnisch, Tuck Wah Soong
Long-term potentiation (LTP) is the persistent increase in the strength of the synapses. However, the neural networks would become saturated if there is only synaptic strenghthening. Synaptic weakening could be facilitated by active processes like long-term depression (LTD). Molecular mechanisms that facilitate the weakening of synapses and thereby stabilize the synapses are also important in learning and memory. Here we show that blockade of dopaminergic D4 receptors (D4R) promoted the formation of late-LTP and transformed early-LTP into late-LTP...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138107/effect-of-low-frequency-electrical-stimulation-on-the-high-k-induced-neuronal-hyperexcitability-in-rat-hippocampal-slices
#14
Zahra Ghasemi, Nima Naderi, Amir Shojaei, Mohammad Reza Raoufy, Nooshin Ahmadirad, Javad Mirnajafi-Zadeh
Low frequency electrical stimulation (LFS) is a potential therapeutic method for epilepsy treatment. However, the effect of different LFS characteristics including the number of pulses, intensity and the time of application on its antiepileptic action has not been completely determined. In the present study, epileptiform activity (EA) was induced in hippocampal slices by high-K(+) solution which washed out after 20 min. The changes in the electrophysiological properties of CA1 pyramidal neurons were measured during and 30 min after EA using whole cell patch clamp recording...
November 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/29137651/abnormal-dendritic-calcium-activity-and-synaptic-depotentiation-occur-early-in-a-mouse-model-of-alzheimer-s-disease
#15
Yang Bai, Miao Li, Yanmei Zhou, Lei Ma, Qian Qiao, Wanling Hu, Wei Li, Zachary Patrick Wills, Wen-Biao Gan
BACKGROUND: Alzheimer's disease (AD) is characterized by amyloid deposition, tangle formation as well as synapse loss. Synaptic abnormalities occur early in the pathogenesis of AD. Identifying early synaptic abnormalities and their underlying mechanisms is likely important for the prevention and treatment of AD. METHODS: We performed in vivo two-photon calcium imaging to examine the activities of somas, dendrites and dendritic spines of layer 2/3 pyramidal neurons in the primary motor cortex in the APPswe/PS1dE9 mouse model of AD and age-matched wild type control mice...
November 14, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29136610/explicit-ringing-removal-in-image-deblurring
#16
Ali Mosleh, Yasser Elmi Sola, Farzad Zargari, Emmanuel Onzon, J M Pierre Langlois
In this paper, we present a simple yet effective image deblurring method to produce ringing-free deblurred images. Our work is inspired by the observation that large-scale deblurring ringing artifacts are measurable through a multi-resolution pyramid of low-pass filtering of the blurred-deblurred image pair. We propose to model such a quantification as a convex cost function and minimize it directly in the deblurring process in order to reduce ringing regardless of its cause. An efficient primal-dual algorithm is proposed as a solution to this optimization problem...
February 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29136106/cell-type-specific-burst-firing-interacts-with-theta-and-beta-activity-in-prefrontal-cortex-during-attention-states
#17
B Voloh, T Womelsdorf
Population-level theta and beta band activity in anterior cingulate and prefrontal cortices (ACC/PFC) are prominent signatures of self-controlled, adaptive behaviors. But how these rhythmic activities are linked to cell-type specific activity has remained unclear. Here, we suggest such a cell-to-systems level linkage. We found that the rate of burst spiking events is enhanced particularly during attention states and that attention-specific burst spikes have a unique temporal relationship to local theta and beta band population-level activities...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29135473/controllable-nanoscale-inverted-pyramids-for-high-efficient-quasi-omnidirectional-crystalline-silicon-solar-cells
#18
Haiyuan Xu, Sihua Zhong, Yufeng Zhuang, Wenzhong Shen
Nanoscale inverted pyramid structures (NIPs) have always been regarded as one of the most paramount light management schemes to achieve the extraordinary performance in various devices, especially in solar cells, due to their outstanding antireflection ability with relative lower surface enhancement ratio. However, the current approaches to fabricating the NIPs are complicated and not cost-effective for the massive cell production in the photovoltaic industry. Here, controllable NIPs are fabricated on crystalline silicon (c-Si) wafers by Ag catalyzed chemical etching and alkaline modification, which is a preferable all-solution-processed method...
November 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29134514/expression-of-bc1-impairs-spatial-learning-and-memory-in-alzheimer-s-disease-via-app-translation
#19
Tongmei Zhang, Pei Pang, Zemin Fang, Yu Guo, Hao Li, Xinyan Li, Tian Tian, Xin Yang, Wenting Chen, Shu Shu, Na Tang, Jianhua Wu, Houze Zhu, Lei Pei, Dan Liu, Qing Tian, Jian Wang, Lin Wang, Ling-Qiang Zhu, Youming Lu
Aggregation of amyloid-β (Aβ) peptides, which are the cleavage products of amyloid precursor protein (APP), is a major pathological hallmark in the brain of Alzheimer's disease (AD). Now, we know little about the roles of APP translation in the disease progression of AD. Here, we show that BC1, a long noncoding RNA (lncRNA), is expressed in the brain of AD mice. BC1 induces APP mRNA translation via association with a fragile X syndrome protein (FMRP). Inhibition of BC1 or BC1-FMRP association in AD mice blocks aggregation of Aβ in the brain and protects against the spatial learning and memory deficits...
November 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29131596/dioxygenation-reaction-of-a-cobalt-nitrosyl-putative-formation-of-a-cobalt-peroxynitrite-via-a-co-iii-no-o2-intermediate
#20
Kuldeep Gogoi, Soumen Saha, Baishakhi Mondal, Hemanta Deka, Somnath Ghosh, Biplab Mondal
A cobalt-nitrosyl complex, [(BPI)Co(NO)(OAc)], 1 {BPI = 1,3-bis(2'-pyridylimino)isoindol} was prepared and characterized. Structural characterization revealed that the cobalt center has a distorted square pyramidal geometry with the NO group coordinated from the apical position in a bent fashion. The addition of dioxygen (O2) to the dichloromethane solution of complex 1 resulted in the formation of nitro complex, [(BPI)Co(NO2)(OAc)], 2. It was characterized structurally. Kinetic studies suggested the involvement of an associative mechanism...
November 13, 2017: Inorganic Chemistry
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