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https://www.readbyqxmd.com/read/29450848/automated-pathogenesis-based-diagnosis-of-lumbar-neural-foraminal-stenosis-via-deep-multiscale-multitask-learning
#1
Zhongyi Han, Benzheng Wei, Stephanie Leung, Ilanit Ben Nachum, David Laidley, Shuo Li
Pathogenesis-based diagnosis is a key step to prevent and control lumbar neural foraminal stenosis (LNFS). It conducts both early diagnosis and comprehensive assessment by drawing crucial pathological links between pathogenic factors and LNFS. Automated pathogenesis-based diagnosis would simultaneously localize and grade multiple spinal organs (neural foramina, vertebrae, intervertebral discs) to diagnose LNFS and discover pathogenic factors. The automated way facilitates planning optimal therapeutic schedules and relieving clinicians from laborious workloads...
February 15, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29447462/exploring-talk-about-sexuality-and-living-gay-social-lives-among-chinese-and-south-asian-gay-and-bisexual-men-in-auckland-new-zealand
#2
Jeffery Adams, Stephen Neville
OBJECTIVE: To identify ways Chinese and South Asian gay and bisexual men living in Auckland talk about issues related to sexuality and experiences of living 'gay social lives.' Results will be available to inform health policy and practice. DESIGN: A qualitative design with individual interviews and thematic analysis was used. Semi-structured digitally recorded interviews were undertaken with 27 Chinese and 17 South Asian gay and bisexual men living in Auckland...
February 15, 2018: Ethnicity & Health
https://www.readbyqxmd.com/read/29441041/altered-brain-functional-connectome-in-migraine-with-and-without-restless-legs-syndrome-a-resting-state-functional-mri-study
#3
Fu-Chi Yang, Kun-Hsien Chou, Ai-Ling Hsu, Jong-Ling Fuh, Jiing-Feng Lirng, Hung-Wen Kao, Ching-Po Lin, Shuu-Jiun Wang
Background: Migraine is frequently comorbid with restless legs syndrome (RLS), both displaying functional connectivity (FC) alterations in multiple brain networks, although the neurological basis of this association is unknown. Methods: We performed resting-state functional magnetic resonance imaging and network-wise analysis of FC in migraine patients with and without RLS and healthy controls (CRL). Network-based statistics (NBS) and composite FC matrix analyses were performed to identify the patterns of FC changes...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29439328/impact-of-total-knee-arthroplasty-with-general-anesthesia-on-brain-networks-cognitive-efficiency-and-ventricular-volume-predict-functional-connectivity-decline-in-older-adults
#4
Haiqing Huang, Jared Tanner, Hari Parvataneni, Mark Rice, Ann Horgas, Mingzhou Ding, Catherine Price
 Using resting state functional magnetic resonance imaging (RS-fMRI), we explored: 1) pre- to post-operative changes in functional connectivity in default mode, salience, and central executive networks after total knee arthroplasty (TKA) with general anesthesia, and 2) the contribution of cognitive/brain reserve metrics these resting state functional declines. Individuals age 60 and older electing unilateral total knee arthroplasty (TKA; n = 48) and non-surgery peers with osteoarthritis (n = 45) completed baseline cognitive testing and baseline and post-surgery (post-baseline, 48-h post-surgery) brain MRI...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29436054/sensorimotor-network-alterations-in-children-and-youth-with-prenatal-alcohol-exposure
#5
Xiangyu Long, Graham Little, Christian Beaulieu, Catherine Lebel
Children with prenatal alcohol exposure (PAE) often have impaired sensorimotor function. While altered brain structure has been noted in sensorimotor areas, the functional brain alterations remain unclear. This study aims to investigate sensorimotor brain networks in children and youth with PAE using resting-state functional magnetic resonance imaging (rs-fMRI). A parcellation-based network analysis was performed to identify brain networks related to hand/lower limb and face/upper limb function in 59 children and youth with PAE and 50 typically developing controls...
February 12, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29430771/factors-associated-with-romantic-relationship-formation-difficulties-in-women-with-breast-cancer
#6
L-K Shaw, K A Sherman, J Fitness, E Elder
OBJECTIVE: Many un-partnered women report difficulty in forming romantic relationships after breast cancer, characterized by high dating-related anxiety and low perceived interpersonal competence. This study examined the relationship between poor body image (appearance investment and body dissatisfaction) and self-compassion, and women's ability to form romantic relationships post-breast cancer. METHODS: Women (N=152) diagnosed with breast cancer, who were either un-partnered and expressed interest in romantic dating, or who had commenced a relationship post-diagnosis, completed an online survey...
February 12, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29422882/disrupted-brain-intrinsic-networks-and-executive-dysfunction-in-cirrhotic-patients-without-overt-hepatic-encephalopathy
#7
Zhe-Ting Yang, Hua-Jun Chen, Qiu-Feng Chen, Hailong Lin
Objective: Patients with cirrhosis often exhibit cognitive deficits, particularly executive dysfunction, which is considered a predictor of overt hepatic encephalopathy (OHE). We examined brain intrinsic networks associated with executive function to investigate the neural basis of this cognitive deficiency in cirrhosis. Methods: Resting-state functional MRI data were acquired from 20 cirrhotic patients and 18 healthy controls. Seed-based correlation analysis was used to identify the three well-known networks associated with executive function, including executive control (ECN), default mode (DMN), and salience (SN) networks...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29422088/associations-of-bcl-2-rs956572-genotype-groups-in-the-structural-covariance-network-in-early-stage-alzheimer-s-disease
#8
Chiung-Chih Chang, Ya-Ting Chang, Chi-Wei Huang, Shih-Jen Tsai, Shih-Wei Hsu, Shu-Hua Huang, Chen-Chang Lee, Wen-Neng Chang, Chun-Chung Lui, Chia-Yi Lien
BACKGROUND: Alzheimer's disease (AD) is a complex neurodegenerative disease, and genetic differences may mediate neuronal degeneration. In humans, a single-nucleotide polymorphism in the B-cell chronic lymphocytic leukemia/lymphoma-2 (Bcl-2) gene, rs956572, has been found to significantly modulate Bcl-2 protein expression in the brain. The Bcl-2 AA genotype has been associated with reduced Bcl-2 levels and lower gray matter volume in healthy populations. We hypothesized that different Bcl-2 genotype groups may modulate large-scale brain networks that determine neurobehavioral test scores...
February 8, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29410199/effect-of-distress-on-transient-network-dynamics-and-topological-equilibrium-in-phantom-sound-perception
#9
Anusha Mohan, Sandra Jovanovic Alexandra, Cliff V Johnson, Dirk De Ridder, Sven Vanneste
Distress is a domain-general behavioral symptom whose neural correlates have been under investigation for a long time now. Although some studies suggest that distress is encoded by changes in alpha activity and functional connectivity between specific brain regions, no study that we know has delved into the whole brain temporal dynamics of the distress component. In the current study, we compare the changes in the mean and variance of functional connectivity and small-worldness parameter over 3 min of resting state EEG to analyze the fluctuation in transient stable states, and network structure...
February 1, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29410103/frontoparietal-areas-link-impairments-of-large-scale-intrinsic-brain-networks-with-aberrant-fronto-striatal-interactions-in-ocd-a-meta-analysis-of-resting-state-functional-connectivity
#10
REVIEW
Deniz A Gürsel, Mihai Avram, Christian Sorg, Felix Brandl, Kathrin Koch
Neuroimaging studies report evidence for two distinct pathophysiological models of obsessive-compulsive disorder (OCD): disrupted fronto-striatal circuits and impaired large-scale fronto-parietal-limbic intrinsic brain networks, defined by functionally connected (FC) infra-slow oscillations in ongoing brain activity. To synthesize this literature and overcome inconsistencies, we conducted a coordinate-based meta-analysis of 18 whole-brain resting-state functional magnetic resonance imaging (fMRI) studies (541 patients, 572 healthy controls) comparing seed-based FC between OCD patients and healthy controls...
February 3, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29402737/anxiety-and-threat-related-attention-cognitive-motivational-framework-and-treatment
#11
REVIEW
Karin Mogg, Brendan P Bradley
Research in experimental psychopathology and cognitive theories of anxiety highlight threat-related attention biases (ABs) and underpin the development of a computer-delivered treatment for anxiety disorders: attention-bias modification (ABM) training. Variable effects of ABM training on anxiety and ABs generate conflicting research recommendations, novel ABM training procedures, and theoretical controversy. This article summarises an updated cognitive-motivational framework, integrating proposals from cognitive models of anxiety and attention, as well as evidence of ABs...
February 2, 2018: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/29398207/effective-connectivity-within-a-triple-network-brain-system-discriminates-schizophrenia-spectrum-disorders-from-psychotic-bipolar-disorder-at-the-single-subject-level
#12
Lena Palaniyappan, Gopikrishna Deshpande, Pradyumna Lanka, D Rangaprakash, Sarina Iwabuchi, Susan Francis, Peter F Liddle
OBJECTIVE: Schizophrenia spectrum disorders (SSD) and psychotic bipolar disorder share a number of genetic and neurobiological features, despite a divergence in clinical course and outcome trajectories. We studied the diagnostic classification potential that can be achieved on the basis of the structure and connectivity within a triple network system (the default mode, salience and central executive network) in patients with SSD and psychotic bipolar disorder. METHODS: Directed static connectivity and its dynamic variance was estimated among 8 nodes of the three large-scale networks...
February 2, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29395610/disrupted-salience-processing-involved-in-motivational-deficits-for-real-life-activities-in-patients-with-schizophrenia
#13
Byung-Hoon Kim, Yu-Bin Shin, Sunghyon Kyeong, Seon-Koo Lee, Jae-Jin Kim
Motivational deficits in patients with schizophrenia adversely affect various domains of daily living. This symptom in everyday life situations manifests in a complex behavioral pattern whose root cannot be simplified to an impaired reward-motivation scheme. This study aimed to identify impairment of the salience network that underlies motivational deficits seen in patients with schizophrenia in real-life situations. During the functional magnetic resonance imaging scan, 20 patients with schizophrenia and 20 normal controls performed a task mimicking real-life situations, in which an avatar proposed participation in a daily activity with either an intrinsic or extrinsic reward...
January 27, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29391243/incentives-facilitate-developmental-improvement-in-inhibitory-control-by-modulating-control-related-networks
#14
Michael N Hallquist, Charles F Geier, Beatriz Luna
Adolescence is a period of heightened sensitivity to incentives and relatively weak cognitive control, which may contribute to risky behaviors. Studies of brain activity have generally identified greater activation of the ventral striatum to rewards and less activation of prefrontal regions during control tasks in adolescents compared to adults. Little is known, however, about age-related changes in the functional brain networks underlying incentive processing and cognitive control. This cross-sectional study characterized the effects of incentives on inhibitory control during an oculomotor task using whole-brain functional connectivity analyses...
January 29, 2018: NeuroImage
https://www.readbyqxmd.com/read/29384450/deep-brain-stimulation-of-the-ventral-striatal-area-for-post-stroke-pain-syndrome-a-magnetoencephalography-study
#15
Raghavan Gopalakrishnan, Richard C Burgess, Donald A Malone, Scott F Lempka, John T Gale, Darlene P Floden, Kenneth B Baker, Andre G Machado
Post-stroke pain syndrome (PSPS) is an intractable disorder characterized by hemiparesis associated with unrelenting chronic pain. While traditional analgesia have largely failed, integrative approaches targeting affective-cognitive spheres have started to show promise. Recently, we demonstrated that deep brain stimulation (DBS) of the ventral striatal area significantly improved the affective sphere of pain (Lempka et al. 2017) in PSPS patients. Here, we examine whether electrophysiological correlates of pain anticipation were modulated by DBS that could serve as signatures of treatment effects...
January 31, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29382543/coupling-and-segregation-of-large-scale-brain-networks-predict-individual-differences-in-delay-discounting
#16
Zhiyi Chen, Yiqun Guo, Tingyong Feng
Decision-making about rewards, which requires us to choose between different time points, generally refers to intertemporal choice. Converging evidence suggests that some of the brain networks recruited in the delay discounting task have been well characterized for intertemporal choice. However, little is known about how the connectivity patterns of these large-scale brain networks are associated with delay discounting. Here, we use a resting-state functional connectivity MRI (rs-fcMRI) and a graph theoretical analysis to address this question...
January 27, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29382021/altered-effective-connectivity-of-resting-state-networks-by-acupuncture-stimulation-in-stroke-patients-with-left-hemiplegia-a-multivariate-granger-analysis
#17
Cai-Hong Fu, Kuang-Shi Li, Yan-Zhe Ning, Zhong-Jian Tan, Yong Zhang, Hong-Wei Liu, Xiao Han, Yi-Huai Zou
The aim of this study was to explore the response feature of resting-state networks (RSNs) of stroke patients with left hemiplegia by acupuncture stimulation.Nineteen stroke patients with left hemiplegia and 17 controls were recruited in this study. Resting-state functional magnetic resonance imaging data before and after acupuncture were acquired using magnetic scanning. The independent component analysis (ICA) was employed to extract RSNs related to motion, sensation, cognition, and execution, including sensorimotor network (SMN), left and right frontoparietal network (LFPN and RFPN), anterior and posterior default mode network (aDMN, pDMN), visual network (VN), and salience network (SN)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29370266/increased-parietal-circuit-breaker-activity-in-delta-frequency-band-and-abnormal-delta-theta-band-connectivity-in-salience-network-in-hyperacusis-subjects
#18
Jae Joon Han, Ji Hye Jang, Dirk De Ridder, Sven Vanneste, Ja-Won Koo, Jae-Jin Song
Recent studies have suggested that hyperacusis, an abnormal hypersensitivity to ordinary environmental sounds, may be characterized by certain resting-state cortical oscillatory patterns, even with no sound stimulus. However, previous studies are limited in that most studied subjects with other comorbidities that may have affected cortical activity. In this regard, to assess ongoing cortical oscillatory activity in idiopathic hyperacusis patients with no comorbidities, we compared differences in resting-state cortical oscillatory patterns between five idiopathic hyperacusis subjects and five normal controls...
2018: PloS One
https://www.readbyqxmd.com/read/29365199/neurobiological-correlates-of-emotional-intelligence-in-voice-and-face-perception-networks
#19
Kathrin N Karle, Thomas Ethofer, Heike Jacob, Carolin Brück, Michael Erb, Martin Lotze, Sophia Nizielski, Astrid Schütz, Dirk Wildgruber, Benjamin Kreifelts
Facial expressions and voice modulations are among the most important communicational signals to convey emotional information. The ability to correctly interpret this information is highly relevant for successful social interaction and represents an integral component of emotional competencies that have been conceptualized under the term emotional intelligence. Here, we investigated the relationship of emotional intelligence as measured with the Salovey-Caruso-Emotional-Intelligence-Test (MSCEIT) with cerebral voice and face processing using functional and structural magnetic resonance imaging...
January 22, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29365198/altered-functional-connectivity-of-the-default-mode-network-in-patients-with-schizo-obsessive-comorbidity-a-comparison-between-schizophrenia-and-obsessive-compulsive-disorder
#20
Yong-Ming Wang, Lai-Quan Zou, Wen-Lan Xie, Zhuo-Ya Yang, Xiong-Zhao Zhu, Eric F C Cheung, Thomas Alrik Sørensen, Arne Møller, Raymond C K Chan
Clinical and neuroimaging data support the idea that schizo-obsessive comorbidity (SOC), similar to obsessive-compulsive disorder (OCD) and schizophrenia (SCZ), may be a distinct brain disorder. In this study, we examined the strength of resting-state functional connectivity (rsFC) between 19 subregions of the default mode network (DMN) and whole brain voxels in 22 patients with SOC features, 20 patients with SCZ alone, 22 patients with OCD, and 22 healthy controls (HC). The main results demonstrated that patients with SOC exhibited the highest rsFC strength within subregions of the DMN and the lowest rsFC strength between the DMN and subregions of the salience network (SN) compared with the other 3 groups...
January 20, 2018: Schizophrenia Bulletin
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