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https://www.readbyqxmd.com/read/29678964/technology-enabled-examinations-of-cardiac-rhythm-optic-nerve-oral-health-tympanic-membrane-gait-and-coordination-evaluated-jointly-with-routine-health-screenings-an-observational-study-at-the-2015-kumbh-mela-in-india
#1
Pratik Shah, Gregory Yauney, Otkrist Gupta, Vincent Patalano Ii, Mrinal Mohit, Rikin Merchant, S V Subramanian
OBJECTIVES: Technology-enabled non-invasive diagnostic screening (TES) using smartphones and other point-of-care medical devices was evaluated in conjunction with conventional routine health screenings for the primary care screening of patients. DESIGN: Dental conditions, cardiac ECG arrhythmias, tympanic membrane disorders, blood oxygenation levels, optic nerve disorders and neurological fitness were evaluated using FDA-approved advanced smartphone powered technologies...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678760/sub-millimeter-ecog-pitch-in-human-enables-higher-fidelity-cognitive-neural-state-estimation
#2
John Hermiz, Nicholas Rogers, Erik Kaestner, Mehran Ganji, Daniel R Cleary, Bob Carter, David Barba, Shadi Dayeh, Eric Halgren, Vikash Gilja
Electrocorticography (ECoG), electrophysiological recording from the pial surface of the brain, is a critical measurement technique for clinical neurophysiology, basic neurophysiology studies, and demonstrates great promise for the development of neural prosthetic devices for assistive applications and the treatment of neurological disorders. Recent advances in device engineering are poised to enable orders of magnitude increase in the resolution of ECoG without comprised measurement quality. This enhancement in cortical sensing enables the observation of neural dynamics from the cortical surface at the micrometer scale...
April 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29678707/long-term-clinical-and-radiological-postoperative-outcomes-after-c1-c2-pedicle-screw-techniques-for-pediatric-atlantoaxial-rotatory-dislocation
#3
Xinjie Wu, Yafeng Li, Mingsheng Tan, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
BACKGROUND: Although C1-C2 pedicle screw techniques have been extensively reported in paediatric series, reports on their use have examined only small series with short follow-up periods. Here, we present a study on paediatric patients with atlantoaxial rotatory dislocation (AARD) treated with these techniques with a minimum 5-year follow-up period. METHODS: A total of 27 paediatric patients with AARD who underwent C1-C2 pedicle screw fixation between 2004 and 2012 were retrospectively evaluated...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678648/determinants-of-health-related-quality-of-life-1-year-after-pulmonary-thromboendarterectomy
#4
Oksana Kamenskaya, Asya Klinkova, Irina Loginova, Alexander Chernyavskiy, Alexander Edemskiy, Vladimir V Lomivorotov, Alexander Karaskov
AIM: Pulmonary thromboendarterectomy (PTE) is a recognized treatment for patients with chronic thromboembolic pulmonary hypertension (CTEPH), with good long-term haemodynamic results. The aim of this study was to test the hypothesis that the dynamics of health-related quality of life (QoL), 1 year after PTE, depends both on the clinical determinants associated with the underlying disease and the adverse events occurring in the early postoperative period. METHODS: This prospective cohort study included 136 patients with CTEPH...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678449/using-primary-organotypic-mouse-midbrain-cultures-to-examine-developmental-neurotoxicity-of-silver-nanoparticles-across-two-genetic-strains
#5
Brittany A Weldon, Julie Juyoung Park, Sungwoo Hong, Tomomi Workman, Russell Dills, Ji Hyun Lee, William C Griffith, Terrance J Kavanagh, Elaine M Faustman
Micromass culture systems have been developed as three-dimensional organotypic in vitro alternatives to test developmental toxicity. We have optimized a murine-based embryonic midbrain micromass system in two genetic strains to evaluate neurodevelopmental effects of gold-cored silver nanoparticles (AgNPs) of differing sizes and coatings-20 nm AgCitrate, 110 nm AgCitrate, and 110 nm AgPVP. AgNPs are increasingly used in consumer, commercial, and medical products for their antimicrobial properties and observations of Ag in adult and fetal brain following in vivo exposures to AgNPs have led to concerns about the potential for AgNPs to elicit adverse effects on neurodevelopment and neurological function...
April 17, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29676694/keyhole-strategy-aiming-at-minimizing-hospital-stay-for-surgical-clipping-of-unruptured-middle-cerebral-artery-aneurysms
#6
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes. METHODS A total of 160 relatively small unruptured MCA aneurysms (mean 6...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676588/lysine-acetyltransferase-inhibitors-structure-activity-relationships-and-potential-therapeutic-implications
#7
Francesco Fiorentino, Antonello Mai, Dante Rotili
Lysine acetylation is a post-translational modification of both histone and nonhistone proteins that is catalyzed by lysine acetyltransferases and plays a key role in numerous biological contexts. The dysregulation of this enzyme activity is implicated in many human pathologies such as cancer, neurological and inflammatory disorders. Many lysine acetyltransferase inhibitors (KATi) have been developed so far, but there is still the need for new, more potent, metabolically stable and selective KATi as chemical tools for studying KAT biology and/or as potential therapeutic agents...
April 20, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29675071/pediatric-head-injury-a-study-of-403-cases-in-a-tertiary-care-hospital-in-a-developing-country
#8
Abrar Ahad Wani, Arif Hussain Sarmast, Muzaffar Ahangar, Nayil Khursheed Malik, Sarabjit Singh Chhibber, Sajad Hussain Arif, Altaf Umar Ramzan, Bashir Ahmed Dar, Zulfiqar Ali
Introduction: Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse. Aims and Objectives: The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Materials and Methods: Patients with TBI, 18 years or less in age, managed in our Department of Neurosurgery, over a period of 2 years, were studied prospectively...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674371/automation-of-ct-based-haemorrhagic-stroke-assessment-for-improved-clinical-outcomes-study-protocol-and-design
#9
Betty Chinda, George Medvedev, William Siu, Martin Ester, Ali Arab, Tao Gu, Sylvain Moreno, Ryan C N D'Arcy, Xiaowei Song
INTRODUCTION: Haemorrhagic stroke is of significant healthcare concern due to its association with high mortality and lasting impact on the survivors' quality of life. Treatment decisions and clinical outcomes depend strongly on the size, spread and location of the haematoma. Non-contrast CT (NCCT) is the primary neuroimaging modality for haematoma assessment in haemorrhagic stroke diagnosis. Current procedures do not allow convenient NCCT-based haemorrhage volume calculation in clinical settings, while research-based approaches are yet to be tested for clinical utility; there is a demonstrated need for developing effective solutions...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674196/clinical-and-imaging-profile-of-patients-with-new-onset-seizures-a-presumptive-diagnosis-of-eclampsia-a-prospective-observational-study
#10
Vandana Bojja, Anish Keepanasseril, Pradeep P Nair, V C Sunitha
OBJECTIVE: To study the clinical and imaging profile of patients with new-onset seizures with a presumptive diagnosis of eclampsia. METHODS: This was a cross-sectional study, conducted in a tertiary teaching hospital, on pregnant women presenting with new onset seizures with presumptive diagnosis of eclampsia excluding those with pre-existing neurological conditions. Demographic details, medical and obstetric examination findings were noted. All women underwent neuroimaging within 5 days of onset seizures...
February 25, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673456/-intracerebroventricular-injection-of-mir-7-inhibits-secondary-brain-injury-induced-by-intracerebral-hemorrhage-via-egfr-stat3-pathway-in-rats
#11
Hong Qian, Ke Hu, Ming Xie, Heng Wu, Wenjun Li, Bin Wu, Rongyong Man, Meng Nie
Objective To observe the effects of microRNA-7 (miR-7) on intracerebral hemorrhage-induced brain injury in rats and explore the underlying mechanism. Methods Seventy-five SD rats were used to establish intracerebral hemorrhage model through injection of VII collagenase into the pallidum. These rats were then divided into control, miR-7 agomir, agomir control, miR-7 antagomir and antagomir control groups, containing 15 animals in each group. On day 2 after modeling, rats were injected with 10 μL of physiological saline, miR-7 agomir, agomir control, miR-7 antagomir and antagomir control via the lateral ventricle, respectively...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29673420/neurologic-complications-associated-with-transdermal-placement-of-intrathecal-catheters-in-sheep
#12
Gabrielle C Musk, Nolan J McDonnell, Mark Newman, Matthew W Kemp
A study using an ovine model of transdermal intrathecal catheterization was planned to investigate the neurotoxicity ofmagnesium sulfate. Nonpregnant Merino cross ewes (n = 8; age, 5 y; weight, 55.0 ± 6.5 kg) were anesthetized for placementof a lumbar intrathecal catheter. The study protocol defined a 5-d recovery period after introduction of the catheter before theadministration of test substances (2 mL of 0.9% saline or 50 or 150 mg MgSO4) followed by euthanasia 1 wk later. Although 3sheep successfully completed the study as planned, one of the remaining 5 sheep was withdrawn when the catheter was accidentally dislodged 2 d after anesthesia; another was withdrawn because of persistent neurologic deficits of the left hindlimb and intense pruritus during the first 24 h after placement of the catheter; and the remaining 3 animals experienced unacceptable complications within the first 4 h of administration of the test substance...
April 19, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29672091/resting-state-connectivity-dynamics-in-individuals-at-risk-for-psychosis
#13
Andrea Pelletier-Baldelli, Jessica R Andrews-Hanna, Vijay A Mittal
Clarifying dynamic fluctuations in resting-state connectivity in individuals at risk for psychosis (termed clinical high risk [CHR]) may inform understanding of psychotic disorders, such as schizophrenia, which have been associated with dysconnectivity and aberrant salience processing. Dynamic functional connectivity (DFC) investigations provide insight into how neural networks exchange information over time. Currently, there are no published DFC studies involving CHR individuals. This is notable, because understanding how networks may come together and disassociate over time could lend insight into the neural communication that underlies psychosis development and symptomatology...
April 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29672072/reduced-awareness-for-apraxic-deficits-in-left-hemisphere-stroke
#14
Mona Kusch, Sarah Gillessen, Jochen Saliger, Hans Karbe, Ellen Binder, Gereon R Fink, Simone Vossel, Peter H Weiss
OBJECTIVE: Reduced awareness for motor or cognitive impairments has mainly been studied in relation to right-hemispheric deficits such as left-sided hemiparesis. However, recent studies suggest that also left hemisphere (LH) stroke can lead to reduced awareness for neurological/neuropsychological deficits, for example, aphasia. The aim of the current study was to characterize reduced awareness for apraxic as well as aphasic deficits in patients suffering from LH stroke. METHOD: After the assessment of apraxia and aphasia, patients (n = 32) were asked to rate their performance on a 1- to 5-point rating scale...
April 19, 2018: Neuropsychology
https://www.readbyqxmd.com/read/29671179/clinical-infection-in-house-rats-rattus-rattus-caused-by-streptobacillus-notomytis
#15
Viktoria Michel, Claudia Ulber, Dietrich Pöhle, Beate Köpke, Katharina Engel, Ute Kaim, Ahmad Fawzy, Sophie Funk, Juliane Fornefett, Christoph Georg Baums, Tobias Eisenberg
Rat bite fever is an under-reported, under-diagnosed emerging zoonosis with worldwide distribution. Besides Spirillum minus, Streptobacillus moniliformis is the major causative microorganism although it usually colonises rats without any clinical signs. A group of house rats (Rattus rattus) kept in a zoo exhibition for educational purposes suffered from neurological signs including disorientation, torticollis, stall walking, ataxia and death. Gross pathological and histo-pathological examinations of the investigated rats revealed high-grade otitis interna et media, from which Streptobacillus notomytis was isolated in pure culture or as the predominant microorganism...
April 18, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29671047/atypical-outbreak-of-acute-coenurosis-by-taenia-multiceps-in-a-sheep-flock
#16
Davide Pintus, Antonio Varcasia, Giorgia Dessì, Claudia Tamponi, Maria Lucia Manunta, Giovanni Antonio Carboni, Maria Giovanna Cancedda, Ciriaco Ligios, Antonio Scala
Herein, we examined the brain of adult ewes and lambs less than 30 days old which were found affected by neurological signs in a flock located in Sardinia (Italy). Gross anatomo-pathological examination of all brains of the animals revealed multiple linear reddish-yellow foci of necrotic purulent inflammation due to oncosphere migration. Histologically, we confirmed a multifocal pyo-granulomatous meningo-encephalitis both in ewes and in lambs, confirming acute coenurosis. Morphological examination and DNA sequencing identified the Taenia multiceps we isolated as Tm1 strain...
April 18, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29670827/vasculitis-and-neurobrucellosis-evaluation-of-nine-cases-using-radiologic-findings
#17
Sule Aydin Turkoglu, Siddika Halicioglu, Fatma Sirmatel, Murside Yildiz, Nebil Yildiz, Serpil Yildiz
Background: Brucellosis is an important multisystemic disease with many different clinical symptoms, and its early diagnosis and treatment are possible. Neurobrucellosis (NB) is a rare but serious finding of brucellosis. Brucella can be seen as meningitis and encephalopathy, and it can cause cranial nerve pathologies, vascular syndromes, myopathy, spinal diseases, and psychiatric disorders. In NB, vascular syndromes secondary to inflammation are rarely seen. Here, we present nine young patients with vascular and nonspecific neuropsychiatric findings who had NB as the etiology of stroke...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29670407/first-episode-psychosis-as-the-initial-presentation-of-multiple-sclerosis-a-case-report
#18
Athena Enderami, Rose Fouladi, Seyed Hamzeh Hosseini
Background: Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system (CNS). MS with episode of psychosis is a rare entity, and to the best of our knowledge, no case has been reported from Iran till date. Case presentation: We report a case of MS with first-episode psychosis in a 27-year-old single man with no history of psychiatric disorder or drug abuse. The patient developed neurological symptoms after 3 months and was finally diagnosed as a case of MS...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29669868/improving-microcirculatory-reperfusion-reduces-parenchymal-oxygen-radical-formation-and-provides-neuroprotection
#19
Aslihan Taskiran-Sag, Muge Yemisci, Yasemin Gursoy-Ozdemir, Sefik Evren Erdener, Hulya Karatas, Deniz Yuce, Turgay Dalkara
BACKGROUND AND PURPOSE: Reperfusion is the most significant determinant of good outcome after ischemic stroke. However, complete reperfusion often cannot be achieved, despite satisfactory recanalization. We hypothesized that microvascular protection was essential for achieving effective reperfusion and, hence, neuroprotection. To test this hypothesis, we have developed an in vivo model to differentially monitor parenchymal and vascular reactive oxygen species (ROS) formation. By comparing the ROS-suppressing effect of N-tert-butyl-α-phenylnitrone (PBN) with its blood-brain barrier impermeable analog 2-sulfo-phenyl-N-tert-butylnitrone (S-PBN), we assessed the impact of vascular ROS suppression alone on reperfusion and stroke outcome after recanalization...
April 18, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29669602/cerebral-vasculitis-and-lateral-rectus-palsy-two-rare-central-nervous-system-complications-of-dengue-fever-two-case-reports-and-review-of-the-literature
#20
H M M Herath, J S Hewavithana, C M De Silva, O A R Kularathna, N P Weerasinghe
BACKGROUND: Dengue fever is a common mosquito-borne viral illness with a clinical spectrum ranging from a simple febrile illness to potentially life-threatening complications such as dengue hemorrhagic fever and dengue shock syndrome. Dengue infection can affect many organs, including the central nervous system. The neurological manifestations reported in dengue infections are meningitis, encephalitis, stroke, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. CASE PRESENTATION: We report the cases of two interesting patients with confirmed dengue infection who presented with complications of possible central nervous system vasculitis and cranial nerve palsy...
April 19, 2018: Journal of Medical Case Reports
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