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https://www.readbyqxmd.com/read/29470304/index-case-of-cutaneous-follicular-mycosis-fungoides-with-central-nervous-system-involvement-and-review-of-literature
#1
Giang Huong Nguyen, Alexander Mohler, Michelle Leppert, Cindy Parra, Yue-Ping Zeng, Lori Prok, Jeffrey Schowinsky, Cynthia M Magro, Theresa Pacheco, Douglas Ney
Central nervous system involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages of the disease. We describe a patient with early-stage follicular MF who presented with changes in mental status. Despite an initial diagnosis of vasculitis based on clinical and brain biopsy results, the postmortem examination revealed extensive infiltration of MF cells throughout the brain with leptomeningeal involvement. This case in addition to the accompanied review of literature illustrates the importance of the awareness of central nervous system involvement by MF and highlights the need for an urgent neurologic evaluation in patients with a history of MF now presenting with neurologic signs or symptoms...
March 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29469347/-mri-findings-of-cerebral-schistosomiasis-in-acute-stage%C3%AF-establishment-of-experimental-model-of-acute-cerebral-schistosomiasis-with-rabbits
#2
Ge Yu-Xi, Zhang Lian-He, Yan Gen, Zhang Jian-Feng, Pan Yong-Ming, Xuan Ying-Hua
OBJECTIVE: To establish an experimental model of acute cerebral schistosomiasis japonica and explore the MRI manifestations of acute cerebral schistosomiasis. METHODS: Rabbits were divided into 3 groups with 10 rabbits in each group. The rabbits in the experimental group were directly injected with suspension fluid of Schistosoma japonicum eggs (0.9 mg, 1 ml) by the cranial drilling method, those in the negative control group were given saline (1 ml) by the same method above-mentioned, and those in the blank control group were not given any treatment...
June 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29468662/predictive-validity-of-spontaneous-early-infant-movement-for-later-cerebral-palsy-a-systematic-review
#3
REVIEW
Amanda K L Kwong, Tara L Fitzgerald, Lex W Doyle, Jeanie L Y Cheong, Alicia J Spittle
AIM: To systematically review the predictive validity of spontaneous early infant movements for later cerebral palsy (CP). METHOD: Cohort studies with published data to calculate predictive validity of early spontaneous movements for later CP were searched in four electronic databases: CINAHL, Embase, MEDLINE, and PsycINFO. RESULTS: Forty-seven studies met inclusion criteria. The Prechtl General Movements Assessment (GMA) during the fidgety period (10-20wks corrected age) had the strongest sensitivity: 97 per cent (95% confidence interval [CI] 93-99) and specificity: 89% (95% CI 83-93)...
February 22, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29468621/fusarium-brain-abscess-in-a-patient-with-diabetes-mellitus-and-liver-cirrhosis
#4
Yu-Ju Chen, Chao-Liang Chou, Kuan-Ju Lai, Ya-Ju Lin Lin
PURPOSE: Invasive mycosis caused by the Aspergillus, Fusarium, and Mucor can be fetal, especially in the immunocompromised patients with central nervous system (CNS) involvement. Here we present a case of CNS Fusarium infection, and this is the first reported case of Fusarium brain abscess in Taiwan. CASE REPORT: A 65-year-old woman presented with fever and conscious disturbance for 3 days. Neurological examination showed stupor consciousness, neck stiffness, multiple cranial nerves palsy, and bilateral Babinski signs...
September 15, 2017: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/29468336/parenting-a-child-with-phenylketonuria-pku-an-interpretative-phenomenological-analysis-ipa-of-the-experience-of-parents
#5
Katie Carpenter, Anja Wittkowski, Dougal J Hare, Emma Medford, Stewart Rust, Simon A Jones, Debbie M Smith
Phenylketonuria (PKU) is a rare inherited metabolic disorder which can cause neurological damage if left untreated. PKU is identified through newborn screening in developed countries, and treatment begins immediately to prevent these severe consequences. When a child is diagnosed, parents must assume immediate responsibility for the management of PKU and prevention of neurological damage. Quantitative studies have identified significant psychosocial stressors for parents, but little is known about how the parents experience this process...
February 21, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29468175/rapamycin-prevents-cerebral-stroke-by-modulating-apoptosis-and-autophagy-in-penumbra-in-rats
#6
Meiling Wu, Huadan Zhang, Jiejing Kai, Feng Zhu, Jingyin Dong, Ziwei Xu, Michael Wong, Ling-Hui Zeng
Objective: Whether activation or inhibition of the mTOR pathway is beneficial to ischemic injury remains controversial. It may result from the different reaction of ischemic penumbra and core to modulation of mTOR pathway after cerebral ischemia-reperfusion injury in rats. Methods: Longa's middle cerebral artery occlusion (MCAO) method was conducted to induce the focal cerebral ischemia-reperfusion. Western blot analysis was used to examine the protein expression involving mTOR pathway, apoptosis, and autophagy-related proteins...
February 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29467568/commentary-addressing-racial-disparities-in-stroke-the-wide-spectrum-investigation-of-stroke-outcome-disparities-on-multiple-levels-wissdom
#7
EDITORIAL
Robert J Adams, Charles Ellis, Gayenell Magwood, Mark S Kindy, Leonardo Bonilha, Daniel T Lackland
Racial-ethnic disparities in stroke recovery are well-established in the United States but the underlying causes are not well-understood. The typical assumption that racial-ethnic disparities in stroke recovery are explained by health care access inequities may be simplistic as access to stroke-related rehabilitation, for example, does not adequately explain the observed disparities. To approach the problem in a more comprehensive fashion, the Wide Spectrum Investigation of Stroke Outcome Disparities on Multiple Levels (WISSDOM) was developed to bring together scientists from Regenerative Medicine, Neurology, Rehabilitation, and Nursing to examine disparities in stroke "recovery...
2018: Ethnicity & Disease
https://www.readbyqxmd.com/read/29467523/early-low-dose-hydrocortisone-is-the-neurodevelopment-affected
#8
Gaston Ofman, Marta Perez, Kathryn N Farrow
TYPE OF INVESTIGATION: Prognosis; exploratory secondary analysis of an interventional randomized controlled trial. QUESTION: In extremely preterm infant (<28 weeks), is early low-dose hydrocortisone compared to placebo associated with neurodevelopmental impairment at 2 years of age? METHODS: Patients: Surviving infants enrolled in the PREMILOC trial conducted in France between 2008 and 2014. INTERVENTION: Double-blind, multicenter, randomized, placebo-controlled trial of infants born between 24 0/7 weeks and 27 6/7 weeks of gestation and before 24 h of postnatal age, assigned to receive either placebo or low-dose hydrocortisone (0...
February 21, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29467350/influence-of-nitrous-oxide-on-granule-cell-migration-in-the-dentate-gyrus-of-the-neonatal-rat
#9
Hitoshi Saito, Rui Kato, Toshikazu Hashimoto, Yosuke Uchida, Tetsutaro Hase, Kenkichi Tsuruga, Koichi Takita, Yuji Morimoto
For several decades, the neurotoxicities of anesthetics to the developing brain have been reported by many researchers focusing on various phenomena such as apoptosis, neurodegeneration, electrophysiological aberrations, and behavioral abnormalities. According to these reports, signals via N-methyl-D-aspartate receptors (NMDA-r) and/or γ-aminobutyric acid type A receptors (GABAA -r) are implicated in the anesthetic neurotoxicity. On the other hand, during brain development, NMDA-r and GABAA -r are also recognized to play primary roles in neural cell migration...
2018: Biomedical Research
https://www.readbyqxmd.com/read/29467306/gait-analysis-in-psp-and-nph-dual-task-conditions-make-the-difference
#10
Charlotte Selge, Florian Schoeberl, Andreas Zwergal, Georg Nuebling, Thomas Brandt, Marianne Dieterich, Roman Schniepp, Klaus Jahn
OBJECTIVE: To test whether quantitative gait analysis of gait under single- and dual-task conditions can be used for a differential diagnosis of progressive supranuclear palsy (PSP) and idiopathic normal-pressure hydrocephalus (iNPH). METHODS: In this cross-sectional study, temporal and spatial gait parameters were analyzed in 38 patients with PSP (Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy diagnostic criteria), 27 patients with iNPH (international iNPH guidelines), and 38 healthy controls...
February 21, 2018: Neurology
https://www.readbyqxmd.com/read/29466806/vitamin-d-and-its-role-in-neonatal-hypoxic-ischemic-brain-injury
#11
Lyndsey E Stessman, Eric S Peeples
Emerging evidence has demonstrated that vitamin D plays an important role in many adult neurologic disorders, but is also critical in neuronal development and pruning in the neonatal and pediatric populations. Neonates are at a particularly high risk of vitamin D deficiency, in part due to the high prevalence of maternal deficiency during pregnancy. Several preclinical studies have demonstrated that infants born to vitamin D-deficient mothers are at a high risk of developing neonatal brain injury, and recent clinical studies have shown that neonates with hypoxic-ischemic encephalopathy (HIE) tend to be vitamin D-deficient...
February 21, 2018: Neonatology
https://www.readbyqxmd.com/read/29465033/-headache-in-children-and-adolescents
#12
Caroline Gren, Kristoffer Vogler, Maria Miranda, Nanette Mol Debes
Headache is an increasingly common symptom among children and adolescents with a prevalence of 58.4%, and it may have profound impact on everyday life. A poorer prognosis is seen for children, who are not referred to specialist care, and long-term follow-up is shown to indicate a better outcome. A thorough headache history and a full neurological examination is vital to a correct diagnosis. The acute and prophylactic treatment is poorly studied, but acetaminophen and ibuprofen are first-line choices in acute treatment, and prophylactic treatment should be carried out by specialists...
February 12, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29462368/dural-cells-release-factors-which-promote-cancer-cell-malignancy-and-induce-immunosuppressive-markers-in-bone-marrow-myeloid-cells
#13
Nicholas J Szerlip, Alexandra Calinescu, Eleanor Smith, Rebecca Tagett, Katrina L Clines, Henry H Moon, Russell S Taichman, Catherine H Van Poznak, Gregory A Clines
BACKGROUND: Thirty per cent of cancer patients develop spine metastases with a substantial number leading to spinal cord compression and neurological deficits. Many demonstrate a propensity toward metastasis to the posterior third of the vertebral body. The dura, the outer layer of the meninges, lies in intimate contact with the posterior border of the vertebral body and has been shown to influence adjacent bone. The effects of the dura on bone marrow and cancer cells have not been examined...
February 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29462057/segmental-spinal-myoclonus-complicating-lumbar-transforaminal-epidural-steroid-injection
#14
Stanley Sau Ching Wong, Qiu Qiu, Chi Wai Cheung
OBJECTIVE: Lumbar transforaminal epidural steroid injection is commonly used for treating lumbar radicular pain. We report a case of segmental spinal myoclonus that developed during lumbar transforaminal epidural injection with local anesthetic and steroid. CASE REPORT: A 58-year-old woman with failed back surgery syndrome presented with low back and right L3 and L4 radicular pain. As she had responded well previously to diagnostic selective nerve root injection with local anesthetic at the right L3 and L4 levels, lumbar transforaminal epidural steroid injection at the same levels was scheduled...
February 16, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29462034/acute-thoracolumbar-spinal-cord-injury-relationship-of-cord-compression-to-neurological-outcome
#15
Peta Skeers, Camila R Battistuzzo, Jillian M Clark, Stephen Bernard, Brian J C Freeman, Peter E Batchelor
BACKGROUND: Spinal cord injury in the cervical spine is commonly accompanied by cord compression and urgent surgical decompression may improve neurological recovery. However, the extent of spinal cord compression and its relationship to neurological recovery following traumatic thoracolumbar spinal cord injury is unclear. The purpose of this study was to quantify maximum cord compression following thoracolumbar spinal cord injury and to assess the relationship among cord compression, cord swelling, and eventual clinical outcome...
February 21, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29460911/-masks-of-acute-neuroinfections-and-markers-of-differencial-diagnosis
#16
A S Shishov, I S Petrova, P V Boytsov, V G Leva, V E Malikov, S A Rusanova, A V Surovikina, I A Blank
AIM: To compare thе medical history, clinical features, composition of cerebrospinal fluid (CSF), results of laboratory and instrumental examinations of patients with acute neuroinfections and differentiable diseases including a pseudoinflammatory variant of the acute stage of uncomplicated subarachnoid hemorrhage (SAH), consequences of traumatic brain injury (traumatic SAH, SAN combination with secondary purulent meningitis, posttraumatic nasal liquorrhea, intracerebral hematomas), abscesses and tumors of the brain, lymphoma with proven CNS...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29460904/-syndrome-of-autonomic-dysfunction-in-children-and-adolescents
#17
L S Chutko, T L Kornishina, S Yu Surushkina, E A Yakovenko, T I Anisimova, M B Volov
AIM: To study clinical and pathophysiological symptoms of autonomic dysfunction syndrome in children and adolescents and assess the efficacy of its treatment with nooclerin. MATERIAL AND METHODS: Fifty-three patients, aged from 10 to 15 years, with autonomic dysfunction syndrome were examined. All patients underwent neurological examination, assessment with the A.M. Vein's questionnaire of autonomic disorders, the 10 point Visual Analogous scale for headache and fatigue, the Spielberger-Khanin scale for anxiety, Kerdo index, Hildebrandt's coefficient, electrocardiography with clinoorthostatic test, electroencephalography, and TOVA psychophysiological test...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29460492/cerebrospinal-fluid-lyme-multiplex-assay-results-are-not-diagnostic-in-horses-with-neuroborreliosis
#18
Amy L Johnson, Laura K Johnstone, Darko Stefanovski
BACKGROUND: The accuracy of the Lyme multiplex assay for the diagnosis of neuroborreliosis in horses is unknown. HYPOTHESIS/OBJECTIVES: To describe Lyme multiplex results in horses with a postmortem diagnosis of neuroborreliosis. The hypothesis was that paired serum and cerebrospinal fluid (CSF) results and a CSF : serum ratio would allow differentiation of horses with neuroborreliosis from those with other neurologic diseases. ANIMALS: Ninety horses that had neurologic examinations, serum and CSF Lyme multiplex analyses, and postmortem examination of the nervous system performed...
February 20, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29459137/microstructural-visual-pathway-abnormalities-in-patients-with-primary-glaucoma-3-t-diffusion-kurtosis-imaging-study
#19
Z F Xu, J S Sun, X H Zhang, Y Y Feng, A Z Pan, M Y Gao, H Zhao
AIM: To evaluate microstructural visual pathway damage in patients with primary glaucoma (PG) by using 3 T diffusion kurtosis imaging (DKI). MATERIALS AND METHODS: The study was approved by the ethics committee, and all participants provided written informed consent. Ten patients with PG were examined. Twenty healthy individuals served as control subjects. DKI was performed with a GE Silent 3 T magnetic resonance imaging (MRI) unit. Mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) maps were automatically created...
February 16, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29459084/a-screening-method-to-distinguish-syndromic-from-sporadic-spinal-extradural-arachnoid-cyst
#20
Yoji Ogura, Shoji Yabuki, Shunsuke Fujibayashi, Eijiro Okada, Akio Iwanami, Kota Watanabe, Masaya Nakamura, Morio Matsumoto, Ken Ishii, Shiro Ikegawa
BACKGROUND: Spinal extradural arachnoid cyst (SEDAC) is a cystic lesion that protrudes into the epidural space from a small dural defect. Early diagnosis of SEDAC is important because its expansion causes neurological damage. Two types of SEDAC, syndromic and sporadic, are present. Syndromic SEDAC is inherited as a part of lymphedema-distichiasis syndrome caused by mutations in the FOXC2 gene; however, it is often mistaken as sporadic because of low penetrance. It is not reasonable to conduct a genetic testing for all SEDAC patients and their family members...
February 16, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
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