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Methylation of sites CpG in promoter of MCP-1 in cardiovascular diseases

Qiang Cao, Xianfeng Wang, Lin Jia, Ashis K Mondal, Abdoulaye Diallo, Gregory A Hawkins, Swapan K Das, John S Parks, Liqing Yu, Huidong Shi, Hang Shi, Bingzhong Xue
Inflammation marks all stages of atherogenesis. DNA hypermethylation in the whole genome or specific genes is associated with inflammation and cardiovascular diseases. Therefore, we aimed to study whether inhibiting DNA methylation by DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) ameliorates atherosclerosis in low-density lipoprotein receptor knockout (Ldlr(-/-)) mice. Ldlr(-/-) mice were fed an atherogenic diet and adminisered saline or 5-aza-dC (0.25 mg/kg) for up to 30 weeks. 5-aza-dC treatment markedly decreased atherosclerosis development in Ldlr(-/-) mice without changes in body weight, plasma lipid profile, macrophage cholesterol levels and plaque lipid content...
December 2014: Endocrinology
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