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Photodynamic therapy immunotherapy

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https://www.readbyqxmd.com/read/27903969/targeting-tissue-factor-as-a-novel-therapeutic-oncotarget-for-eradication-of-cancer-stem-cells-isolated-from-tumor-cell-lines-tumor-xenografts-and-patients-of-breast-lung-and-ovarian-cancer
#1
Zhiwei Hu, Jie Xu, Jijun Cheng, Elizabeth McMichael, Lianbo Yu, William E Carson Iii
Targeting cancer stem cell (CSC) represents a promising therapeutic approach as it can potentially fight cancer at its root. The challenge is to identify a surface therapeutic oncotarget on CSC. Tissue factor (TF) is known as a common yet specific surface target for cancer cells and tumor neovasculature in several solid cancers. However, it is unknown if TF is expressed by CSCs. Here we demonstrate that TF is constitutively expressed on CD133 positive (CD133+) or CD24-CD44+ CSCs isolated from human cancer cell lines, tumor xenografts from mice and breast tumor tissues from patients...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27807692/tissue-factor-is-an-angiogenic-specific-receptor-for-factor-vii-targeted-immunotherapy-and-photodynamic-therapy
#2
Zhiwei Hu, Jijun Cheng, Jie Xu, Wolfram Ruf, Charles J Lockwood
Identification of target molecules specific for angiogenic vascular endothelial cells (VEC), the inner layer of pathological neovasculature, is critical for discovery and development of neovascular-targeting therapy for angiogenesis-dependent human diseases, notably cancer, macular degeneration and endometriosis, in which vascular endothelial growth factor (VEGF) plays a central pathophysiological role. Using VEGF-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, we examined the expression of tissue factor (TF), a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls...
November 2, 2016: Angiogenesis
https://www.readbyqxmd.com/read/27793900/the-use-of-toll-like-receptor-4-agonist-to-reshape-the-immune-signature-in-ovarian-cancer
#3
Eva Vindevogel, Thaïs Baert, Anaïs VAN Hoylandt, Godelieve Verbist, Greetje Vande Velde, Abhishek D Garg, Patricia Agostinis, Ignace Vergote, A N Coosemans
BACKGROUND: Dendritic cell (DC) mono-immunotherapy has not been successful so far in ovarian cancer. The addition of a toll-like receptor (TLR) agonist has the potential to boost the innate immune system, in addition to the adoptive immune response initiated by DCs. MATERIALS AND METHODS: ID8-fLuc C57BL/6 mice were injected with DCs loaded with hypericin-based photodynamic therapy-treated tumor lysate. A TLR4 agonist [lipopolysaccharide (LPS)] was administered by different schedules)...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27785021/carbon-nanotubes-as-cancer-therapeutic-carriers-and-mediators
#4
REVIEW
Kuk Hui Son, Jeong Hee Hong, Jin Woo Lee
Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27575718/chlorin-based-nanoscale-metal-organic-framework-systemically-rejects-colorectal-cancers-via-synergistic-photodynamic-therapy-and-checkpoint-blockade-immunotherapy
#5
Kuangda Lu, Chunbai He, Nining Guo, Christina Chan, Kaiyuan Ni, Ralph R Weichselbaum, Wenbin Lin
Photodynamic therapy (PDT) can destroy local tumors and minimize normal tissue damage, but is ineffective at eliminating metastases. Checkpoint blockade immunotherapy has enjoyed recent success in the clinic, but only elicits limited rates of systemic antitumor response for most cancers due to insufficient activation of the host immune system. Here we describe a treatment strategy that combines PDT by a new chlorin-based nanoscale metal-organic framework (nMOF), TBC-Hf, and a small-molecule immunotherapy agent that inhibits indoleamine 2,3-dioxygenase (IDO), encapsulated in the nMOF channels to induce systemic antitumor immunity...
September 28, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27569086/ablation-of-the-locally-advanced-pancreatic-cancer-an-introduction-and-brief-summary-of-techniques
#6
Athanasios Petrou, Demetrios Moris, Patrick Paul Tabet, Brian David Wensley Richards, Georgios Kourounis
Pancreatic ductal adenocarcinoma is a lethal and late presenting malignancy with dismal survival rates. An estimated total of 330,000 people died from this malignancy in 2012. Although there have been improvements in diagnostic and treatment methods, the survival of late stage pancreatic cancer has not shown significant improvement in the past 4 decades. Multiple treatment approaches are available including chemotherapy, radiotherapy, and immunotherapy, but to this day surgical resection remains the only curative treatment option...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27530650/core-shell-nanoscale-coordination-polymers-combine-chemotherapy-and-photodynamic-therapy-to-potentiate-checkpoint-blockade-cancer-immunotherapy
#7
Chunbai He, Xiaopin Duan, Nining Guo, Christina Chan, Christopher Poon, Ralph R Weichselbaum, Wenbin Lin
Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the antibodies inhibiting the PD-1/PD-L1 axis, are among the most promising immunotherapies for patients with advanced colon cancer, but their durable response rate remains low. We herein report the use of immunogenic nanoparticles to augment the antitumour efficacy of PD-L1 antibody-mediated cancer immunotherapy. Nanoscale coordination polymer (NCP) core-shell nanoparticles carry oxaliplatin in the core and the photosensitizer pyropheophorbide-lipid conjugate (pyrolipid) in the shell (NCP@pyrolipid) for effective chemotherapy and photodynamic therapy (PDT)...
August 17, 2016: Nature Communications
https://www.readbyqxmd.com/read/27525587/acid-activatable-versatile-micelleplexes-for-pd-l1-blockade-enhanced-cancer-photodynamic-immunotherapy
#8
Dangge Wang, Tingting Wang, Jianping Liu, Haijun Yu, Shi Jiao, Bing Feng, Fangyuan Zhou, Yuanlei Fu, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Zhaocai Zhou, Yaping Li
Photodynamic therapy (PDT) has emerged as a promising clinical modality for cancer therapy due to its ability to initiate an antitumor immune response. However, PDT-mediated cancer immunotherapy is severely impaired by tumor-cell immunosuppression of host T cell antitumor activity through the programmed cell death 1 ligand (PD-L1) and programmed cell death receptor 1 (PD-1) (PD-L1-PD-1) immune checkpoint pathway. Here, we demonstrate that PDT-mediated cancer immunotherapy can be augmented by PD-L1 knockdown (KD) in tumor cells...
September 14, 2016: Nano Letters
https://www.readbyqxmd.com/read/27471605/dc-vaccine-generated-by-ala-pdt-induced-immunogenic-apoptotic-cells-for-skin-squamous-cell-carcinoma
#9
Jie Ji, Yunfeng Zhang, Wei R Chen, Xiuli Wang
Dendritic cell (DC) vaccines were generated by apoptotic squamous cell carcinoma (SCC) cells induced by 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT). ALA-PDT-DC vaccine inhibited the growth of SCC in mice, indicating that immunogenic apoptotic cells can activate an effective antitumor adaptive immunity and lead to a DC vaccine-based cancer immunotherapy.
June 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27429612/fluorescence-guided-resection-of-malignant-glioma-with-5-ala
#10
Sadahiro Kaneko, Sadao Kaneko
Malignant gliomas are extremely difficult to treat with no specific curative treatment. On the other hand, photodynamic medicine represents a promising technique for neurosurgeons in the treatment of malignant glioma. The resection rate of malignant glioma has increased from 40% to 80% owing to 5-aminolevulinic acid-photodynamic diagnosis (ALA-PDD). Furthermore, ALA is very useful because it has no serious complications. Based on previous research, it is apparent that protoporphyrin IX (PpIX) accumulates abundantly in malignant glioma tissues after ALA administration...
2016: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/26989887/nanoparticle-targeting-of-neutrophils-for-improved-cancer-immunotherapy
#11
Dafeng Chu, Qi Zhao, Jian Yu, Faya Zhang, Hui Zhang, Zhenjia Wang
Cancer immunotherapy using tumor-specific monoclonal antibodies presents a novel approach for cancer treatment. A monoclonal antibody TA99 specific for gp75 antigen of melanoma initiates neutrophil recruitment in tumor responsible for cancer therapy. Here, a strategy is reported for hijacking neutrophils in vivo using nanoparticles (NPs) to deliver therapeutics into tumor. In a mouse model of melanoma, it is shown that systemically delivered albumin NPs increase in tumor when TA99 antibody is injected; and the NP tumor accumulation is mediated by neutrophils...
May 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/26936504/dendritic-cell-vaccines-based-on-immunogenic-cell-death-elicit-danger-signals-and-t-cell-driven-rejection-of-high-grade-glioma
#12
Abhishek D Garg, Lien Vandenberk, Carolien Koks, Tina Verschuere, Louis Boon, Stefaan W Van Gool, Patrizia Agostinis
The promise of dendritic cell (DC)-based immunotherapy has been established by two decades of translational research. Of the four malignancies most targeted with clinical DC immunotherapy, high-grade glioma (HGG) has shown the highest susceptibility. HGG-induced immunosuppression is a roadblock to immunotherapy, but may be overcome by the application of T helper 1 (T(H)1) immunity-biased, next-generation, DC immunotherapy. To this end, we combined DC immunotherapy with immunogenic cell death (ICD; a modality shown to induce T(H)1 immunity) induced by hypericin-based photodynamic therapy...
March 2, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/26847542/a-specific-photoimmunotheranostics-agent-to-detect-and-eliminate-skin-cancer-cells-expressing-egfr
#13
Verena von Felbert, Dirk Bauerschlag, Nicolai Maass, Karen Bräutigam, Ivo Meinhold-Heerlein, Mira Woitok, Stefan Barth, Ahmad Fawzi Hussain
PURPOSE: The term "theranostics" represents a new paradigm in medicine especially for cancer treatment. This term was coined by Funkhouser in 2002 and defines a reagent that combines therapeutic and diagnostic properties. It is widely believed that theranostics agents will have considerable impact on healthcare before, during, and after disease by improving cancer prognosis and management simultaneously. Current theranostics approaches still rely on passive tumor targeting strategies, which have scattergun effects and tend to damage both neoplastic and non-neoplastic cells...
May 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/26722223/photodynamic-therapy-activates-immune-response-by-disrupting-immunity-homeostasis-of-tumor-cells-which-generates-vaccine-for-cancer-therapy
#14
Yuanhong Zheng, Guifang Yin, Vanminh Le, Anle Zhang, Siyu Chen, Xin Liang, Jianwen Liu
Photodynamic therapy (PDT), a regulatory approved cancer treatment, is reported to be capable of causing immunogenic apoptosis. The current data reveal PDT can cause the dysregulation of "eat me" and "don't eat me" signal by generating reactive oxygen species (ROS) -mediated endoplasmic reticulum (ER) stress. This dysregulation probably contribute to the increased uptake of PDT-killed Lewis lung carcinoma (LLC) cells by homologous dendritic cells (DCs), accompanied by phenotypic maturation (CD80(high), CD86(high), and CD40(high)) and functional stimulation (NO(high), IL-10(absent)) of dendritic cells as well as subsequent T-cell responses...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/26604441/intravesical-immunotherapy-in-nonmuscle-invasive-bladder-cancer
#15
REVIEW
Jan-Friedrich Jokisch, Alexander Karl, Christian Stief
INTRODUCTION: Nonmuscle invasive urothelial cell carcinoma is the most frequent malignancy of the urinary bladder. The high recurrence rate (up to 80%) and risk of progression (up to 30%) reflect the need for long-term follow-up and sometimes multiple interventions. To reduce the rate of recurrences and tumor progression, intravesical immunotherapy, especially the use of Bacille Calmette-Guerin (BCG), represents the gold standard adjuvant treatment of high-risk nonmuscle invasive bladder cancer (NMIBC)...
October 2015: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/26569454/chlorin-e6-mediated-photodynamic-effect-diminishes-therapeutic-potential-of-5-aza-2-deoxycytidine-based-whole-tumour-cell-vaccine-in-mice-bearing-squamous-cell-carcinoma-sccvii
#16
Joanna Marczynska, Magdalena Banas, Krzysztof Guzik, Michal Koltun, Pawel Majewski, Joanna Cichy, Martyna Krzykawska-Serda, Anna Makarska, Mateusz Kwitniewski
After years of setbacks, therapeutic cancer vaccines have become an alternative treatment option. Among the diversity of targeted tumour associated antigens (TAA), cancer-testis antigens (CTAs) are promising targets for cancer immunotherapy because they are highly immunogenic; meanwhile, they are expressed in human tumours of different histological origin but not in adult somatic tissues. Epigenetic modifications, such as DNA methylation, regulate CTAs expression both in normal and cancer cells. 5-Aza-2'-deoxycytidine (5-AZA-CdR), a DNA hypomethylating drug, induces the expression of CTAs in neoplastic cells...
December 2015: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/26569233/immunoregulatory-cell-depletion-improves-the-efficacy-of-photodynamic-therapy-generated-cancer-vaccines
#17
Mladen Korbelik, Judit Banáth, Kyi Min Saw
Photodynamic therapy (PDT)-generated cancer vaccine represents an attractive potential application of PDT, therapeutic modality destroying targeted lesions by localized photooxidative stress. Since immunoregulatory cell activity has become recognized as a major obstacle to effective cancer immunotherapy, the present study examined their participation in the therapeutic effect of PDT cancer vaccine. Following protocols from previous studies, mouse with squamous cell carcinoma SCCVII tumors were vaccinated by SCCVII cells treated by PDT and response monitored by tumor size measurement...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26546617/combination-of-photodynamic-therapy-and-specific-immunotherapy-efficiently-eradicates-established-tumors
#18
Jan Willem Kleinovink, Pieter B van Driel, Thomas J Snoeks, Natasa Prokopi, Marieke F Fransen, Luis J Cruz, Laura Mezzanotte, Alan Chan, Clemens W Löwik, Ferry Ossendorp
PURPOSE: The efficacy of immunotherapy against advanced cancer may be improved by combination strategies. Photodynamic therapy (PDT) is a local tumor ablation method based on localized activation of a photosensitizer, leading to oxygen radical-induced tumor cell death. PDT can enhance antitumor immune responses by release of antigen and danger signals, supporting combination protocols of PDT with immunotherapy. EXPERIMENTAL DESIGN: We investigated the local and systemic immune effects of PDT after treatment of established tumors...
March 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26543495/perspectives-in-intraoperative-diagnostics-of-human-gliomas
#19
REVIEW
O Tyurikova, Y Dembitskaya, K Yashin, M Mishchenko, M Vedunova, I Medyanik, V Kazantsev
Amongst large a variety of oncological diseases, malignant gliomas represent one of the most severe types of tumors. They are also the most common type of the brain tumors and account for over half of the astrocytic tumors. According to different sources, the average life expectancy of patients with various glioblastomas varies between 10 and 12 months and that of patients with anaplastic astrocytic tumors between 20 and 24 months. Therefore, studies of the physiology of transformed glial cells are critical for the development of treatment methods...
2015: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/26314964/resistance-to-anticancer-vaccination-effect-is-controlled-by-a-cancer-cell-autonomous-phenotype-that-disrupts-immunogenic-phagocytic-removal
#20
Abhishek D Garg, Sanne Elsen, Dmitri V Krysko, Peter Vandenabeele, Peter de Witte, Patrizia Agostinis
Immunogenic cell death (ICD) is a well-established instigator of 'anti-cancer vaccination-effect (AVE)'. ICD has shown considerable preclinical promise, yet there remain subset of cancer patients that fail to respond to clinically-applied ICD inducers. Non-responsiveness to ICD inducers could be explained by the existence of cancer cell-autonomous, anti-AVE resistance mechanisms. However such resistance mechanisms remain poorly investigated. In this study, we have characterized for the first time, a naturally-occurring preclinical cancer model (AY27) that exhibits intrinsic anti-AVE resistance despite treatment with ICD inducers like mitoxantrone or hypericin-photodynamic therapy...
September 29, 2015: Oncotarget
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