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Green tea and cancer

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https://www.readbyqxmd.com/read/29651001/effects-of-green-tea-on-mirna-and-microbiome-of-oral-epithelium
#1
Guy R Adami, Christy C Tangney, Jessica L Tang, Yalu Zhou, Saba Ghaffari, Ankur Naqib, Saurabh Sinha, Stefan J Green, Joel L Schwartz
Consumption of green tea (GT) extracts or purified catechins has shown the ability to prevent oral and other cancers and inhibit cancer progression in rodent models, but the evidence for this in humans is mixed. Working with humans, we sought to understand the source of variable responses to GT by examining its effects on oral epithelium. Lingual epithelial RNA and lingual and gingival microbiota were measured before and after 4 weeks of exposure in tobacco smokers, whom are at high risk of oral cancer. GT consumption had on average inconsistent effects on miRNA expression in the oral epithelium...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608894/food-polyphenols-targeting-peptidyl-prolyl-cis-trans-isomerase-pin1
#2
Masafumi Hidaka, Keita Kosaka, Saori Tsushima, Chiyoko Uchida, Katsuhiko Takahashi, Noriko Takahashi, Masayoshi Tsubuki, Yukihiko Hara, Takafumi Uchida
We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity...
March 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29602908/a-review-of-promising-natural-chemopreventive-agents-for-head-and-neck-cancer
#3
Kyle Crooker, Rana Aliani, Megha Ananth, Levi Arnold, Shrikant Anant, Sufi Mary Thomas
Head and neck squamous cell carcinoma (HNSCC) accounts for 300,000 deaths per year worldwide and overall survival rates have shown little improvement over the past three decades. Current treatment methods including surgery, chemotherapy, and radiotherapy leave patients with secondary morbidities. Thus, treatment of HNSCC may benefit from exploration of natural compounds as chemopreventive agents. With excellent safety profiles, reduced toxicities, antioxidant properties, and general acceptance for use as dietary supplements, natural compounds are viewed as a desirable area of investigation for chemoprevention...
March 30, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29580521/yellow-tea-camellia-sinensis-l-a-promising-chinese-tea-processing-chemical-constituents-and-health-benefits
#4
REVIEW
Jingyi Xu, Mei Wang, Jianping Zhao, Yan-Hong Wang, Qian Tang, Ikhlas A Khan
Yellow tea, also known as huángchá in Chinese, is a lightly fermented tea unique to China. As a rare and precious variety of tea, it has gained increasing popularity in recent years because of its pleasant mellow taste and known health benefits such as anti-oxidation, anti-inflammation and anti-cancer properties. Yellow tea is similar to green tea in many ways. The initial production process of both teas is the same, but the production of yellow tea requires additional steps. A unique procedure called "sealed yellowing" is always involved in yellow tea processing to increase the oxidation level and remove the characteristic grassy smell associated with green tea while still preserving its health benefits...
May 2018: Food Research International
https://www.readbyqxmd.com/read/29579174/non-herbal-tea-consumption-and-ovarian-cancer-risk-a-systematic-review-and-meta-analysis-of-observational-epidemiologic-studies-with-indirect-comparison-and-dose-response-analysis
#5
Dongyu Zhang, Alpana Kaushiva, Yuzhi Xi, Tengteng Wang, Nan Li
Ovarian cancer (OC) accounts for 4% of female malignancies worldwide and its prognosis is unfavorable. Currently available epidemiologic data suggest that non-herbal tea consumption may reduce OC risk but these evidences are inconsistent. A comprehensive literature search for observational epidemiologic studies reporting associations between non-herbal tea consumption and OC risk was conducted in electronic databases. A random-effects model was used to synthesize effect measures in binary meta-analysis, and adjusted indirect comparison was used to compare if there was a difference in effects between green tea (GT) and black tea (BT)...
March 20, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29575316/toxicological-effects-of-camellia-sinensis-green-tea-a-review
#6
REVIEW
Zeinab Bedrood, Maryam Rameshrad, Hossein Hosseinzadeh
Many scientific articles proved that green tea (GT), Camellia sinensis, has a great potential to manage central nervous system, cardiovascular, and metabolic diseases and treat cancer and inflammatory disorders. However, it is important to consider that "natural" is not always "safe." Some relevant articles reported side effects of GT, detrimental effects on health. The aim of this study is to provide a classified report about the toxicity of GT and its main constituents in acute, subacute, subchronic, and chronic states...
March 25, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29570984/effects-of-the-green-tea-polyphenol-epigallocatechin-3-gallate-on-glioma-a-critical-evaluation-of-the-literature
#7
Chung T Le, William P J Leenders, Remco J Molenaar, Cornelis J F van Noorden
The review discusses the effects of Epigallocatechin-3-gallate Gallate (EGCG) on glioma as a basis for future research on clinical application of EGCG. Epidemiological studies on the effects of green tea or EGCG on the risk of glioma is inconclusive due to the limited number of studies, the inclusion of all tea types in these studies, and the focus on caffeine rather than EGCG. In vivo experiments using EGCG monotherapy are inconclusive. Nevertheless, EGCG induces cell death, prevents cellular proliferation, and limits invasion in multiple glioma cell lines...
March 23, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29552308/egcg-inhibited-bladder-cancer-t24-and-5637-cell-proliferation-and-migration-via-pi3k-akt-pathway
#8
Ke-Wang Luo, Wing-Yin Lung, Chun-Xie, Xin-Le Luo, Wei-Ren Huang
Epigallocatechin-3-gallate (EGCG), the bioactive polyphenol in green tea, has been demonstrated to have various biological activities. We previously found that EGCG inhibited SW780 tumor growth by down-regulation of NF-κB and MMP-9. This study demonstrated that EGCG inhibited bladder cancer T24 and 5637 cell proliferation and migration via PI3K/AKT pathway, without modulation of NF-κB. Our results showed that treatment of EGCG resulted in significant inhibition of cell proliferation by induction of apoptosis, without obvious toxicity to normal bladder SV-HUC-1 cells...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29482780/diet-and-supplements-in-cancer-prevention-and-treatment-clinical-evidences-and-future-perspectives
#9
REVIEW
Claudio Vernieri, Federico Nichetti, Alessandra Raimondi, Sara Pusceddu, Marco Platania, Franco Berrino, Filippo de Braud
In recent years, calorie-restricted dietary regimens and compounds such as vitamins, curcumin, green tea extracts and omega-3 fatty acids have attracted attention for their potential anticancer effects. While definitive conclusions cannot be drawn in this field, many patients adopt complementary antitumor therapies aiming to improve efficacy or reduce toxicity of chemotherapy, with uncertain benefits and the risk of additional toxicities or antagonistic interactions with standard therapies. In this manuscript, we review the different levels of available evidence to suggest or discourage specific dietary changes or supplement use in the context of cancer prevention, reduction of tumor recurrences and survival prolongation in advanced cancers...
March 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29476965/garlic-green-tea-and-turmeric-extracts-mediated-green-synthesis-of-silver-nanoparticles-phytochemical-antioxidant-and-in-vitro-cytotoxicity-studies
#10
D Arumai Selvan, D Mahendiran, R Senthil Kumar, A Kalilur Rahiman
Phyto-synthesis of silver nanoparticles (AgNPs) was achieved using aqueous garlic, green tea and turmeric extracts, and characterized by different spectroscopic techniques. Phytochemical analysis revealed the presence of rich amount of biochemicals in these extracts, which serve as reducing and capping agents for converting silver nitrate into AgNPs. FT IR spectroscopy confirmed the role of biomolecules in the bioreduction and efficient stabilization of AgNPs. UV-Vis DRS spectra showed a band around 450 nm characteristics of AgNPs...
February 14, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29473233/highly-augmented-drug-loading-and-stability-of-micellar-nanocomplexes-composed-of-doxorubicin-and-poly-ethylene-glycol-green-tea-catechin-conjugate-for-cancer-therapy
#11
Kun Liang, Joo Eun Chung, Shu Jun Gao, Nunnarpas Yongvongsoontorn, Motoichi Kurisawa
Low drug loading and instability in blood circulation are two key challenges that impede the successful clinical translation of nanomedicine, as they result in only marginal therapeutic efficacy and toxic side effects associated with premature drug leakage, respectively. Herein, highly stable and ultrahigh drug loading micellar nanocomplexes (MNCs) based on the self-assembly of the anticancer drug doxorubicin (DOX) and a poly(ethylene glycol)-epigallocatechin-3-O-gallate (EGCG) conjugate are developed. The formation of these MNCs is facilitated by strong favorable intermolecular interactions between the structurally similar aromatic EGCG and DOX molecules, which impart exceptionally high drug-loading capability of up to 88% and excellent thermodynamic and kinetic stability...
February 23, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29472583/antitumor-activities-of-quercetin-and-green-tea-in-xenografts-of-human-leukemia-hl60-cells
#12
Andrana Karla Calgarotto, Victor Maso, Gilberto Carlos Franchi Junior, Alexandre Eduardo Nowill, Paulo Latuf Filho, José Vassallo, Sara Teresinha Olalla Saad
Quercetin is one of the most abundant flavonoids, present in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Green tea is a widely consumed beverage, known for a potential source of free radical scavenging and anti-cancer activities. Herein, we investigate the in vivo antitumor efficacy of quercetin and green tea in human leukemia. Human tumors were xenografted into NOD/SCID mice. Quercetin and green tea reduced tumor growth in HL-60 xenografts accompanied by decreased expression of anti-apoptotic proteins, BCL-2, BCL-XL and MCL-1 and increased expression of BAX, a pro-apoptotic protein...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29468843/gpcr6a-is-a-molecular-target-for-the-natural-products-gallate-and-egcg-in-green-tea
#13
Min Pi, Karan Kapoor, Ruisong Ye, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
SCOPE: The molecular mechanisms whereby gallates in green tea exert metabolic effects are poorly understood. METHODS AND RESULTS: We found that GPRC6A, a multi-ligand sensing G-protein coupled receptor that regulates energy metabolism, sex hormone production and prostate cancer progression, is a target for gallates. Sodium gallate,1 gallic acid (GA) > ethyl gallate (EG) > octyl gallate (OG) dose dependently activated ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected controls...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29466808/impact-of-green-tea-catechin-ecg-and-its-synthesized-fluorinated-analogue-on-prostate-cancer-cells-and-stimulated-immunocompetent-cells
#14
Sven Stadlbauer, Carmen Steinborn, Amy Klemd, Fumihiko Hattori, Ken Ohmori, Keisuke Suzuki, Roman Huber, Philipp Wolf, Carsten Gründemann
Among the known or suspected risk factors, inflammation plays an important role in infectious and non-infectious pathways leading to cancer. Green tea polyphenols have been associated with reducing inflammation and protection against carcinogenesis, especially in prostate cancer. While most of the research in this field, so far, has focussed on epigallocatechin-3- O -gallate only, we studied epicatechin-3- O -gallate, the second most abundant green tea polyphenol with essential therapeutic potential, to obtain a more detailed understanding of its anti-tumor and anti-inflammatory action...
February 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29466429/population-nutrikinetics-of-green-tea-extract
#15
Catharina Scholl, Anna Lepper, Thorsten Lehr, Nina Hanke, Katharina Luise Schneider, Jürgen Brockmöller, Thomas Seufferlein, Julia Carolin Stingl
Green tea polyphenols may contribute to the prevention of cancer and other diseases. To learn more about the pharmacokinetics and interindividual variation of green tea polyphenols after oral intake in humans we performed a population nutrikinetic study of standardized green tea extract. 84 healthy participants took green tea extract capsules standardized to 150 mg epigallocatechin-gallate (EGCG) twice a day for 5 days. On day 5 catechin plasma concentrations were analyzed using non-compartmental and population pharmacokinetic methods...
2018: PloS One
https://www.readbyqxmd.com/read/29456384/tea-polyphenols-and-prevention-of-epigenetic-aberrations-in-cancer
#16
REVIEW
Arundhati Bag, Niladri Bag
Tea polyphenols are secondary metabolites of tea plants and are well known for beneficial health effects. They can protect from a variety of illnesses including cancers. Tea polyphenols can prevent cancer by modulating epigenetic aberrations taking place in DNA methylation, histone modifications, and micro-RNAs. By altering these epimutations, they regulate chromatin dynamics and expression of genes those induce or suppress cancer formation. However, majority of the studies in existing literature are carried out for green tea polyphenols rather than black tea polyphenols despite the fact that black tea is the most commonly consumed form of tea (78%) followed by green tea (20%) and other forms of tea...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29454999/long-term-treatment-with-green-tea-polyphenols-modifies-the-gut-microbiome-of-female-sprague-dawley-rats
#17
Jincheng Wang, Lili Tang, Hongyuan Zhou, Jun Zhou, Travis C Glenn, Chwan-Li Shen, Jia-Sheng Wang
Green tea polyphenols (GTP) have been shown to exert a spectrum of health benefits to animals and humans. It is plausible that the beneficial effects of GTP are a result of its interaction with the gut microbiota. This study evaluated the effect of long-term treatment with GTP on the gut microbiota of experimental rats and the potential linkage between changes of the gut microbiota with the beneficial effects of GTP. Six-month-old Sprague-Dawley rats were randomly allocated into three dosing regimens (0, 0...
January 31, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29433212/application-of-microencapsulation-for-the-safe-delivery-of-green-tea-polyphenols-in-food-systems-review-and-recent-advances
#18
REVIEW
Awa Fanny Massounga Bora, Shaojie Ma, Xiaodong Li, Lu Liu
Green tea has been associated with the prevention and reduction of a wide range of severe health conditions such as cancer, immune, and cardiovascular diseases. The health benefits associated with green tea consumption have been predominantly attributed to green tea polyphenols. The functional properties of green tea polyphenols are mainly anti-oxidative, antimutagenic, anticarcinogenic, anti-microbial, etc. These excellent properties have recently gained considerable attention in the food industry. However, their application is limited by their sensitivity to factors like temperature, light, pH, oxygen, etc...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29429153/cancer-prevention-with-green-tea-and-its-principal-constituent-egcg-from-early-investigations-to-current-focus-on-human-cancer-stem-cells
#19
Hirota Fujiki, Tatsuro Watanabe, Eisaburo Sueoka, Anchalee Rawangkan, Masami Suganuma
Cancer preventive activities of green tea and its main constituent, (-)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. Since 1983, we have studied the cancer chemopreventive effects of EGCG as well as green tea extract and underlying molecular mechanisms. The first part of this review summarizes groundbreaking topics with EGCG and green tea extract: 1) Delayed cancer onset as revealed by a 10-year prospective cohort study, 2) Prevention of colorectal adenoma recurrence by a double-blind randomized clinical phase II trial, 3) Inhibition of metastasis of B16 melanoma cells to the lungs of mice, 4) Increase in the average value of Young's moduli, i...
January 31, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29419740/tea-polysaccharide-prevents-colitis-associated-carcinogenesis-in-mice-by-inhibiting-the-proliferation-and-invasion-of-tumor-cells
#20
Li-Qiao Liu, Hai-Shan Li, Shao-Ping Nie, Ming-Yue Shen, Jie-Lun Hu, Ming-Yong Xie
The imbalance between cell proliferation and apoptosis can lead to tumor progression, causing oncogenic transformation, abnormal cell proliferation and cell apoptosis suppression. Tea polysaccharide (TPS) is the major bioactive component in green tea, it has showed antioxidant, antitumor and anti-inflammatory bioactivities. In this study, the chemoprophylaxis effects of TPS on colitis-associated colon carcinogenesis, especially the cell apoptosis activation and inhibition effects on cell proliferation and invasion were analyzed...
February 8, 2018: International Journal of Molecular Sciences
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