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Green tea and cancer

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https://www.readbyqxmd.com/read/29932300/potential-issues-with-complementary-medicines-commonly-used-in-the-cancer-population-a-retrospective-review-of-a-tertiary-cancer-center-s-experience
#1
Sally L Brooks, Gail Rowan, Michael Michael
AIM: Complementary medicine (CAM) use in the cancer population is higher than the general population: some studies estimate up to 70%. Our Medicines Information Centre, in a tertiary cancer institution, receives many enquiries regarding use and safety of CAM with conventional cancer therapies (chemotherapy, radiotherapy and surgery). This project aims to review the CAM most commonly enquired about with an emphasis on potential interactions with conventional cancer therapies. METHODS: An audit and review of CAM enquiries from patients or medical professionals at our center, over a 2-year period (July 2011-June 2013), was conducted...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29914196/anti-proliferation-effect-of-theasaponin-e%C3%A2-on-the-aldh-positive-ovarian-cancer-stem-like-cells
#2
Ling-Yan Jia, Hui-Long Xia, Zhi-Da Chen, Casey Compton, Heather Bucur, Devendra A Sawant, Gary O Rankin, Bo Li, You-Ying Tu, Yi Charlie Chen
Ovarian cancer has the highest mortality rate of all gynecological malignancies and the five-year death rate of patients has remained high in the past five decades. Recently, with the rise of cancer stem cells (CSCs) theory, an increasing amount of research has suggested that CSCs give rise to tumor recurrence and metastasis. Theasaponin E₁ (TSE₁), which was isolated from green tea ( Camellia sinensis ) seeds, has been proposed to be an effective compound for tumor treatment. However, studies on whether TSE₁ takes effect through CSCs have rarely been reported...
June 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29908579/herbal-sun-protection-agents-human-studies
#3
Lana Rabinovich, Viktoryia Kazlouskaya
Topical sunscreens are the mainstay for protection from ultraviolet (UV) radiation. With skin cancer rates on the rise and great interest in reversing or preventing the effects of photoaging, new molecules with potential to defend against UV damage have received a great deal of attention. Specifically, there is a growing interest in herbal substances that offer protection against the damaging effects of UV rays. Herbal substances may work as adsorbents of the UV rays and antioxidants and potentially have few side effects...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29882797/targeting-histone-deacetylases-with-natural-and-synthetic-agents-an-emerging-anticancer-strategy
#4
REVIEW
Amit Kumar Singh, Anupam Bishayee, Abhay K Pandey
Cancer initiation and progression are the result of genetic and/or epigenetic alterations. Acetylation-mediated histone/non-histone protein modification plays an important role in the epigenetic regulation of gene expression. Histone modification is controlled by the balance between histone acetyltransferase and (HAT) and histone deacetylase (HDAC) enzymes. Imbalance between the activities of these two enzymes is associated with various forms of cancer. Histone deacetylase inhibitors (HDACi) regulate the activity of HDACs and are being used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy...
June 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29878887/case-report-of-a-human-papillomavirus-infection-treated-with-green-tea-extract-and-curcumin-vaginal-compounded-medications
#5
Kelechi E Agbi, Sara Hover, Maria Carvalho
The human papillomaviruses are the most common sexually transmitted infections in the U.S., and the majority of these infections are cleared by the body's natural immune system without causing any harm. The high-risk human papillomavirus types, however, cause approximately 5 percent of all cancers worldwide. A prophylactic vaccine was recently introduced, but there is still no commercially available treatment that targets active infections. This case study discusses a 48-year-old female who was diagnosed as human papillomavirus positive (+) following a routine gynecological examination...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29876987/the-association-between-green-tea-consumption-and-breast-cancer-risk-a-systematic-review-and-meta-analysis
#6
REVIEW
Mona Najaf Najafi, Maryam Salehi, Masumeh Ghazanfarpour, Zeinab Sadat Hoseini, Majid Khadem-Rezaiyan
This systematic review and meta-analysis aimed to critically evaluate the relation between green tea (GT) consumption and the risk of breast cancer. Popular electronic databases were systematically searched for papers in English language. All case-control and cohort studies in addition to randomized clinical trials were included if they assessed the chemopreventive effects of GT on breast cancer. The quality of included studies was assessed using the Newcastle-Ottawa and Jadad scale. This systematic review comprised 14 studies: 9 case-control studies, 4 cohort studies, and 1 clinical trial...
June 7, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29843466/beneficial-effects-of-green-tea-catechins-on-neurodegenerative-diseases
#7
Monira Pervin, Keiko Unno, Tomokazu Ohishi, Hiroki Tanabe, Noriyuki Miyoshi, Yoriyuki Nakamura
Tea is one of the most consumed beverages in the world. Green tea, black tea, and oolong tea are made from the same plant Camellia sinensis (L.) O. Kuntze. Among them, green tea has been the most extensively studied for beneficial effects on diseases including cancer, obesity, diabetes, and inflammatory and neurodegenerative diseases. Several human observational and intervention studies have found beneficial effects of tea consumption on neurodegenerative impairment, such as cognitive dysfunction and memory loss...
May 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29843451/in-vitro-and-in-silico-studies-of-the-molecular-interactions-of-epigallocatechin-3-o-gallate-egcg-with-proteins-that-explain-the-health-benefits-of-green-tea
#8
REVIEW
Koichi Saeki, Sumio Hayakawa, Shogo Nakano, Sohei Ito, Yumiko Oishi, Yasuo Suzuki, Mamoru Isemura
Green tea has been shown to have beneficial effects on many diseases such as cancer, obesity, inflammatory diseases, and neurodegenerative disorders. The major green tea component, epigallocatechin-3- O -gallate (EGCG), has been demonstrated to contribute to these effects through its anti-oxidative and pro-oxidative properties. Furthermore, several lines of evidence have indicated that the binding affinity of EGCG to specific proteins may explain its mechanism of action. This review article aims to reveal how EGCG-protein interactions can explain the mechanism by which green tea/EGCG can exhibit health beneficial effects...
May 28, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29796442/the-favourable-effect-of-catechin-in-electrochemotherapy-in-human-pancreatic-cancer-cells
#9
Olga Michel, Dawid Przystupski, Jolanta Saczko, Anna Szewczyk, Natalia Niedzielska, Joanna Rossowska, Julita Kulbacka
Until recently, green tea polyphenols were considered strong antioxidants. However, the latest reports have revealed that bioflavonoids can play a multiple role in anticancer therapy, including the inhibition of cell proliferation and generation of the oxidative stress in a dose-dependent manner. The presented research was designed to examine the potential of the green tea (±)-catechin as a reinforcement of the electrochemotherapy (ECT) with cisplatin in pancreatic cancer in vitro. The study was performed on two cell lines of the pancreatic ductal adenocarcinoma (PDA) - parental EPP85-181P and multidrug-resistant EPP85-181RNOV...
May 22, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#10
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29751678/-epigallocatechin-3-gallate-synthetic-analogues-inhibit-fatty-acid-synthase-and-show-anticancer-activity-in-triple-negative-breast-cancer
#11
Joan Crous-Masó, Sònia Palomeras, Joana Relat, Cristina Camó, Úrsula Martínez-Garza, Marta Planas, Lidia Feliu, Teresa Puig
(-)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas. To improve the pharmacological profile of EGCG, we previously developed a family of EGCG derivatives and the lead compounds G28, G37 and G56 were characterized in HER2-positive breast cancer cells overexpressing FASN. Here, diesters G28, G37 and G56 and two G28 derivatives, monoesters M1 and M2, were synthesized and assessed in vitro for their cytotoxic, FASN inhibition and apoptotic activities in MDA-MB-231 triple-negative breast cancer (TNBC) cells...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29732447/high-resolution-adhesion-kinetics-of-egcg-exposed-tumor-cells-on-biomimetic-interfaces-comparative-monitoring-of-cell-viability-using-label-free-biosensor-and-classic-end-point-assays
#12
Beatrix Peter, Rita Ungai-Salanki, Bálint Szabó, Agoston G Nagy, Inna Szekacs, Szilvia Bősze, Robert Horvath
A high-throughput label-free resonant waveguide grating biosensor, the Epic BenchTop, was utilized to in situ monitor the adhesion process of cancer cells on Arg-Gly-Asp tripeptide displaying biomimetic polymer surfaces. Using highly adherent human cervical adenocarcinoma (HeLa) cells as a model system, cell adhesion kinetic data with outstanding temporal resolution were obtained. We found that pre-exposing the cells to various concentrations of the main extract of green tea, the (-)-epigallocatechin gallate (EGCG), largely affected the temporal evolution of the adhesion process...
April 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/29690635/quantitative-analysis-of-four-catechins-from-green-tea-extract-in-human-plasma-using-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-for-pharmacokinetic-studies
#13
Jeong-Eun Park, Tae-Eun Kim, Kwang-Hee Shin
Green tea is consumed as a beverage worldwide and has beneficial effects, such as a lower risk of cardiovascular disease and cancer. A quantitative analysis of the beneficial components in plasma is important for understanding the potential health benefits of green tea. Four catechins—epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC), and epicatechin (EC)—which account for the majority of the components of green tea, were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
April 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29688074/perspectives-on-the-recent-developments-with-green-tea-polyphenols-in-drug-discovery
#14
Feng Li, Yongli Wang, Dapeng Li, Yilun Chen, Xuguang Qiao, Rania Fardous, Ashton Lewandowski, Jinbao Liu, Tak-Hang Chan, Q Ping Dou
Increasing evidence has expanded the role of green tea from a traditional beverage to a source of pharmacologically active molecules with diverse health benefits. However, conclusive clinical results are needed to better elucidate the cancer-preventive and therapeutic effects of green tea polyphenols (GTPs). Areas covered: The authors describe GTPs' chemical compositions and metabolic biotransformations, and their recent developments in drug discovery, focusing on their cancer chemopreventive and therapeutic effects...
July 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29681978/flavonoids-effects-on-hepatocellular-carcinoma-in-murine-models-a-systematic-review
#15
REVIEW
Estefanny Ruiz García, Eliana Alviárez Gutierrez, Fabiana Cristina Silveira Alves de Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process. Studies were selected from PubMed and Scopus databases according to the PRISMA statement. The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model. The bias analysis of the 34 selected works was done using the ARRIVE guidelines...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29677167/the-role-of-catechins-in-cellular-responses-to-oxidative-stress
#16
REVIEW
Jurga Bernatoniene, Dalia Marija Kopustinskiene
Catechins are polyphenolic compounds—flavanols of the flavonoid family found in a variety of plants. Green tea, wine and cocoa-based products are the main dietary sources of these flavanols. Catechins have potent antioxidant properties, although in some cases they may act in the cell as pro-oxidants. Catechins are reactive oxygen species (ROS) scavengers and metal ion chelators, whereas their indirect antioxidant activities comprise induction of antioxidant enzymes, inhibition of pro-oxidant enzymes, and production of the phase II detoxification enzymes and antioxidant enzymes...
April 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29671630/the-critical-role-of-epigallocatechin-gallate-in-regulating-mitochondrial-metabolism
#17
Weimei Shi, Linfu Li, Yechun Ding, Kai Yang, Zhixi Chen, Xiaona Fan, Shan Jiang, Yingjie Guan, Zhiping Liu, Daohua Xu, Longhuo Wu
Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits biology-benefiting effects with minimum severe adverse. EGCG is known to be a mitochondrion-targeting medicinal agent, regulating mitochondrial metabolism, including mitochondrial biogenesis, mitochondrial bioenergetics, and mitochondria-mediated cell cycle and apoptosis. EGCG might exhibit either antioxidative activity to prevent against oxidative stress or pro-oxidative activity to counteract cancer cells, which depends on the cellular stress situations, cell types and the concentration of EGCG...
April 1, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29668030/uv-c-irradiation-on-the-quality-of-green-tea-effect-on-catechins-antioxidant-activity-and-cytotoxicity
#18
Matthew J Vergne, Ankit Patras, Manreet S Bhullar, Lincoln M Shade, Michael Sasges, Kanyasiri Rakariyatham, Che Pan, Hang Xiao
Short-wavelength ultraviolet (UV-C) irradiation is a nonthermal processing technique that is a possible alternative to the heat-pasteurization of tea beverages. This study investigated the effect of UV-C irradiation on the polyphenolic and total phenolic contents of a green tea beverage and analyzed cytotoxicity of irradiated green tea using a novel continuous flow-through UV system. UV-C fluence levels ranging from 0 to 240 mJ/cm2 were delivered to green tea, and polyphenols were chemically profiled. Continuous-flow UV-C irradiation of the green tea beverage at a fluence of 68 mJ/cm2  induced a minor reduction in the concentration of the most abundant catechin in green tea, (-)-epigallocatechin gallate (EGCG), from 145 to 131...
May 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29651001/effects-of-green-tea-on-mirna-and-microbiome-of-oral-epithelium
#19
Guy R Adami, Christy C Tangney, Jessica L Tang, Yalu Zhou, Saba Ghaffari, Ankur Naqib, Saurabh Sinha, Stefan J Green, Joel L Schwartz
Consumption of green tea (GT) extracts or purified catechins has shown the ability to prevent oral and other cancers and inhibit cancer progression in rodent models, but the evidence for this in humans is mixed. Working with humans, we sought to understand the source of variable responses to GT by examining its effects on oral epithelium. Lingual epithelial RNA and lingual and gingival microbiota were measured before and after 4 weeks of exposure in tobacco smokers, whom are at high risk of oral cancer. GT consumption had on average inconsistent effects on miRNA expression in the oral epithelium...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608894/food-polyphenols-targeting-peptidyl-prolyl-cis-trans-isomerase-pin1
#20
Masafumi Hidaka, Keita Kosaka, Saori Tsushima, Chiyoko Uchida, Katsuhiko Takahashi, Noriko Takahashi, Masayoshi Tsubuki, Yukihiko Hara, Takafumi Uchida
We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity...
May 15, 2018: Biochemical and Biophysical Research Communications
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