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Green tea and cancer

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https://www.readbyqxmd.com/read/28611670/identification-of-epigallocatechin-3-gallate-as-an-inhibitor-of-phosphoglycerate-mutase-1
#1
Xiaoguang Li, Shuai Tang, Qian-Qian Wang, Elaine L-H Leung, Hongyue Jin, Yongzhuo Huang, Jia Liu, Meiyu Geng, Min Huang, Shengtao Yuan, Xiao-Jun Yao, Jian Ding
Targeting metabolic enzymes is believed to provide new therapeutic opportunities for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that importantly coordinates glycolysis, pentose phosphate pathway (PPP) flux and serine biosynthesis in cancer cells and hence gains increasing interest of inhibitor discovery. Only few PGAM1 inhibitors have been reported and the molecular potency remains very limited. In an effort to discover new PGAM1 inhibitors, we carried out a biochemical assay-based screen that was focused on natural products derived small molecule compounds...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28592119/tea-polyphenol-inhibits-autophagy-to-sensitize-epirubicin-induced-apoptosis-in-human-bladder-cancer-cells
#2
W Gu, Y Lin, X Gou, W He
Resistance to anticancer agents such as Epirubicin (EPI) becomes a great challenge for treating bladder cancer. However, the mechanism by which chemoresistance arised is still elusive. In the present study, we showed evidence that EPI induced cytoprotective autophagy in bladder cancer cell lines T24 and BIU87. In addition, EPI robustly activated JNK-mediated phosphorylation of Bcl-2 and disruption of Bcl-2/Beclin-1 complex. Furthermore, the green tea derivative tea polyphenol (TP) inhibited EPI-induced autophagy and promoted apoptosis induced by EPI in bladder cancer cells...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28587207/-epigallocatechin-3-gallate-inhibits-colorectal-cancer-stem-cells-by-suppressing-wnt-%C3%AE-catenin-pathway
#3
Yue Chen, Xiao-Qian Wang, Qi Zhang, Jian-Yun Zhu, Yuan Li, Chun-Feng Xie, Xiao-Ting Li, Jie-Shu Wu, Shan-Shan Geng, Cai-Yun Zhong, Hong-Yu Han
The beneficial effects of tea consumption on cancer prevention have been generally reported, while (-)-Epigallocatechin-3-gallate (EGCG) is the major active component from green tea. Cancer stem cells (CSCs) play a crucial role in the process of cancer development. Targeting CSCs may be an effective way for cancer intervention. However, the effects of EGCG on colorectal CSCs and the underlying mechanisms remain unclear. Spheroid formation assay was used to enrich colorectal CSCs from colorectal cancer cell lines...
June 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28585285/the-synergistic-potential-of-various-teas-herbs-and-therapeutic-drugs-in-health-improvement-a-review
#4
REVIEW
F Malongane, L J McGaw, F N Mudau
Tea is one of the most widely consumed non-alcoholic beverages in the world next to water. It is classified as Camellia sinensis and non-Camellia sinensis (herbal teas). The common bioactive compounds found mainly in green teas are flavan-3-ols (catechins) (also called flavanols), proanthocyanidins (tannins) and flavonols. Black tea contains theaflavins and thearubigins and white tea contains L-theanine and gamma-aminobutyric acid (GABA), while herbal teas contain diverse polyphenols. Phytochemicals in tea exhibit anti-microbial, anti-diabetic and anti-cancer activities that are perceived to be helpful in managing chronic diseases linked to lifestyle...
June 6, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28566694/production-of-three-phenylethanoids-tyrosol-hydroxytyrosol-and-salidroside-using-plant-genes-expressing-in-escherichia-coli
#5
Daeun Chung, So Yeon Kim, Joong-Hoon Ahn
Polyphenols, which include phenolic acids, flavonoids, stilbenes, and phenylethanoids, are generally known as useful antioxidants. Tyrosol, hydroxytyrosol, and salidroside are typical phenylethanoids. Phenylethanoids are found in plants such as olive, green tea, and Rhodiola and have various biological activities, including the prevention of cardiovascular diseases, cancer, and brain damage. We used Escherichia coli to synthesize three phenylethanoids, tyrosol, hydroxytyrosol, and salidroside. To synthesize tyrosol, the aromatic aldehyde synthase (AAS) was expressed in E...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28551901/-the-role-of-the-plant-artemisia-in-survival-and-induction-of-apoptosis-of-b-cells-in-chronic-lymphocytic-leukemia-cll
#6
Vita Mirkin, Alain Berrebi, Igor Rakhman, Michal Haran, Lev Shvidel
BACKGROUND: The cytotoxic effect of plants such as green tea and turmeric (curcumin) on B chronic lymphocytic leukemia (CLL) cells has been established. The plant Artemisia has been used in China for anti-cancer and anti-malaria applications. In Israel, Artemisia absinthium ("the Chiba") is used to release abdominal pain. In attempts to evaluate the cytotoxic effect of this plant in CLL cells, we prepared a decoction of Artemisia leaves and after filtration used it as an inducer of apoptosis of B CLL cells...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28528106/characterization-of-white-tea-metabolome-comparison-against-green-and-black-tea-by-a-nontargeted-metabolomics-approach
#7
Weidong Dai, Dongchao Xie, Meiling Lu, Pengliang Li, Haipeng Lv, Chen Yang, Qunhua Peng, Yin Zhu, Li Guo, Yue Zhang, Junfeng Tan, Zhi Lin
White tea is considered the least processed form of tea and is reported to have a series of potent bioactivities, such as antioxidant, anti-inflammatory, anti-mutagenic, and anti-cancer activities. However, the chemical composition of white tea and the dynamic changes of the metabolites during the manufacturing process are far from clear. In this study, we applied a nontargeted metabolomics approach based on ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) to comprehensively profile the characteristic metabolites of white tea...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28504421/bioinformatics-analysis-on-molecular-mechanism-of-green-tea-compound-epigallocatechin-3-gallate-against-ovarian-cancer
#8
S Xinqiang, Z Mu, C Lei, L Y Mun
Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea, and it exerts multiple effects in humans through mechanisms that remain to be clarified. The present study used bioinformatics to identify possible mechanisms by which EGCG reduces the risk of ovarian cancer. Possible human protein targets of EGCG were identified in the PubChem database, possible human gene targets were identified in the National Center for Biotechnology Information database, and then both sets of targets were analyzed using Ingenuity Pathway Analysis (IPA)...
May 15, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28503561/green-tea-and-liver-cancer
#9
EDITORIAL
Francesca Bravi, Carlo La Vecchia, Federica Turati
No abstract text is available yet for this article.
April 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28503560/green-tea-and-the-question-of-reduced-liver-cancer-risk-the-dawn-of-potential-clinical-relevance
#10
EDITORIAL
Rolf Teschke, Johannes Schulze
No abstract text is available yet for this article.
April 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28495234/oxidative-stress-induced-akt-downregulation-mediates-green-tea-toxicity-towards-prostate-cancer-cells
#11
Anna Maria Posadino, Hoa Thi Phu, Annalisa Cossu, Roberta Giordo, Marco Fois, Duong Thi Bich Thuan, Antonio Piga, Salvatore Sotgia, Angelo Zinellu, Ciriaco Carru, Gianfranco Pintus
Green tea consumption has been shown to possess cancer chemopreventive activity. Polyphenol E (PE) is a widely used standardized green tea extract formulation. This study was designed to investigate the impact of PE on prostate cancer cells (PC3), analyze the potential signals involved and elucidate whether anti- or pro-oxidant effects may be implicated. Treatment of PC3 cells with 30 and 100μg/ml PE significantly decreased cell viability and proliferation. At the tested concentrations, PE did not exert any antioxidant activity, eliciting instead a pro-oxidant effect at concentrations 30 and 100μg/ml, which was consistent with the observed PE cytotoxicity...
May 7, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28479696/probable-benefits-of-green-tea-with-genetic-implications
#12
REVIEW
Kavita Singhal, Neerja Raj, Khushboo Gupta, Saurabh Singh
Tea is produced from the Camellia sinensis plant and can generally be divided into categories based on how they are processed. In general, green tea that is unfermented C. sinensis has been considered superior to black tea in health benefits. It contains a unique set of catechins that possess biological activity as antioxidant, anti-inflammatory and antiproliferative, which is potentially significant to the prevention and treatment of various forms of diseases. Oral cavity oxidative stress and inflammation, consequent cigarettes due to nicotine and acrolein, may be reduced in the presence of green tea polyphenols...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28465816/breast-cancer-chemopreventive-and-chemotherapeutic-effects-of-camellia-sinensis-green-tea-an-updated-review
#13
REVIEW
Mahmoud Rafieian-Kopaei, Mino Movahedi
INTRODUCTION: Camellia sinensis belongs to the plant family of Theaceae, native to East Asia, the Indian Subcontinent and Southeast Asia, but naturalized in many parts of the world. The aim of this study was to overview its anti-breast cancer chemopreventive and chemotherapeutic effects. This review article is aimed to overview breast cancer chemopreventive and chemotherapeutic effects of Camellia sinensis (green tea). METHODS: This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28465354/egfr-inhibition-by-epigallocatechin-3-gallate-and-iif-treatments-reduces-breast-cancer-cell-invasion
#14
Fulvia Farabegoli, Marzia Govoni, Enzo Spisni, Alessio Papi
Epidermal growth factor receptor (EGFR) expression is an important marker in breast carcinoma pathology and is considered a pivotal molecule for cancer cell proliferation, invasion and metastasis. We investigated the effects of epigallocatechin-3-gallate (EGCG), the most active green tea catechin, in combination with 6-OH-11-O-hydroxyphenanthrene (IIF), a synthetic retinoid X receptor-γ (RXRγ) agonist, on three breast carcinoma cell lines: MCF-7, MCF-7TAM and MDA-MB-231. EGFR and AKT activation and molecular markers of cell motility and migration (CD44, extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN), MMP-2, MMP-9 and tissue inhibitor of metalloproteinases (TIMPs)) were studied after EGCG and IIF treatments...
June 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28462491/in-vitro-evaluation-of-combination-of-egcg-and-erlotinib-with-classical-chemotherapeutics-on-jar-cells
#15
Elçin Telli, Hatice Genç, Burcugül Altuğ Tasa, S Sinan Özalp, A Tansu Koparal
Gestational Trophoblastic Neoplasia (GTN) is a term used for a group of malignant gynecological tumors including choriocarcinoma. Low-risk neoplasias can be cured using single agents Methotrexate (MTX) and actinomycin-D (ACD), but in certain cases, decreased responsiveness and serious side effects occur. Therefore, researchers have been attempting to find new treatment modalities. One of the most popular way for increasing cancer patient survival rates is supporting treatment with adjuvant molecules or chemosensitizers...
May 1, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28458506/intraperitoneal-injection-of-epigallocatechin-3-gallate-protects-against-light-induced-photoreceptor-degeneration-in-the-mouse-retina
#16
Shounan Qi, Chenguang Wang, Delu Song, Ying Song, Joshua L Dunaief
PURPOSE: (-)-epigallocatechin-3-gallate (EGCG), a major catechin component of green tea, is reported to delay or prevent certain forms of cancer, arthritis, cardiovascular disease, and neurodegenerative disorders. In this study, we determined if systemically administered EGCG could protect the retina against light damage (LD) in mice. METHODS: BALB/cJ mice were treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28454102/an-inverse-association-between-tea-consumption-and-colorectal-cancer-risk
#17
Yuetong Chen, Yuan Wu, Mulong Du, Haiyan Chu, Lingjun Zhu, Na Tong, Zhengdong Zhang, Meilin Wang, Dongying Gu, Jinfei Chen
It is well known that the tea extracts, mainly polyphenols as chemo-preventive elements, could act as cancer progression blockers. Although the association between tea consumption and colorectal cancer risk has been widely investigated, the results still remain inconsistent. We conducted a dose-response meta-analysis to evaluate their relationships by enrolling qualified 29 literatures. The summary odds ratio (OR) of colorectal cancer for the highest vs. lowest tea consumption was 0.93 with 0.87-1.00 of 95% confidence intervals (CIs) among all studies with modest heterogeneity (P = 0...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445390/prevention-of-colorectal-cancer-by-targeting-obesity-related-disorders-and-inflammation
#18
REVIEW
Yohei Shirakami, Masaya Ohnishi, Hiroyasu Sakai, Takuji Tanaka, Masahito Shimizu
Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk of colorectal cancer. Therefore, treatments targeting these factors might be a promising strategy to prevent the development of colorectal cancer. Among a number of functional foods, various phytochemicals, including tea catechins, which have anti-inflammatory and anti-obesity properties, and medicinal agents that ameliorate metabolic disorders, might also be beneficial in the prevention of colorectal cancer...
April 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28440509/modulation-of-mmp-2-and-9-secretion-by-cytokines-inducers-and-inhibitors-in-human-melanoma-a-2058-cells
#19
M Waheed Roomi, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath
Melanoma, an extremely aggressive cancer, causes the most skin cancer-related deaths, due to metastasis to other areas of the body, such as lymph nodes, lungs, liver, brain or bone. It is characterized by high levels of matrix metalloproteinase (MMP)-2 and -9 secretions that degrade the extracellular matrix and basement membrane, allowing cancer cells to spread to distal organs. Various cytokines, mitogens, growth factors, inducers and inhibitors control MMP activities. We investigated the roles of these in regulation of MMP-2 and -9 in human melanoma A-2058 cells...
April 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28423656/effect-of-y6-an-epigallocatechin-gallate-derivative-on-reversing-doxorubicin-drug-resistance-in-human-hepatocellular-carcinoma-cells
#20
Yan Wen, Rui-Qiang Zhao, Yun-Kai Zhang, Pranav Gupta, Li-Xiang Fu, An-Zhou Tang, Bu-Ming Liu, Zhe-Sheng Chen, Dong-Hua Yang, Gang Liang
Cancer cells can acquire resistance to a wide variety of diverse and unrelated drugs, this phenomenon is termed multidrug resistance (MDR). Multidrug resistance has been an obstacle to the success of cancer chemotherapy. The present study investigated the reversal effect of Y6, a new compound obtained by chemically modifying the structure of epigallocatechin-3-gallate (EGCG) extracted from green tea. Y6 was proven to be effective in inhibiting cell proliferation and reversing drug resistance in doxorubicin (DOX) resistant human hepatocellular carcinoma cells (BEL-7404/DOX)...
May 2, 2017: Oncotarget
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