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https://www.readbyqxmd.com/read/27933737/testing-the-influence-of-surfactant-based-wound-dressings-on-proteinase-activity
#1
Sunyoung Jeong, Gregory S Schultz, Daniel J Gibson
Proteinases are enzymes that can digest other proteins. In chronic wounds, a sub-class of these enzymes with the ability to degrade the extracellular matrix (matrix metalloproteinases, MMPs) have been found to both inhibit healing and to be able to aid in enzymatically debriding a wound. Enzymatic debridement using the enzymes present in a wound is generally called autolytic debridement. Clinicians seeking to employ autolytic debridement typically use occlusive materials such as medical honey, alginate dressings and other occlusive dressings...
December 8, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27933007/what-is-the-correct-answer-about-the-dress-colors-investigating-the-relation-between-optimism-previous-experience-and-answerability
#2
Bodil S A Karlsson, Carl Martin Allwood
The Dress photograph, first displayed on the internet in 2015, revealed stunning individual differences in color perception. The aim of this study was to investigate if lay-persons believed that the question about The Dress colors was answerable. Past research has found that optimism is related to judgments of how answerable knowledge questions with controversial answers are (Karlsson et al., 2016). Furthermore, familiarity with a question can create a feeling of knowing the answer (Reder and Ritter, 1992)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932078/the-utility-of-vacuum-assisted-closure-therapy-for-skin-necrosis-secondary-to-cervical-abscess-in-the-elderly
#3
Tadataka Tsuji, Koichi Satoh, Emi Okuno, Akiko Sobue, Yoshiya Nishide, Susumu Tanaka, Mikihiko Kogo
Vacuum-assisted closure (VAC) systems have been used as negative-pressure dressings in various fields, including decubitus ulcer, trauma, and wound dehiscence. To the best of our knowledge, few reports have examined the utility of VAC therapy for neck abscess in an oldest-old patient. We present here a rare case of neck abscess secondary to parotid abscess, resulting in extensive skin necrosis. Successful management included emergency drainage following epithelial induction through a VAC system without using skin grafting...
December 5, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27931851/spanish-broom-spartium-junceum-l-fibers-impregnated-with-vancomycin-loaded-chitosan-nanoparticles-as-new-antibacterial-wound-dressing-preparation-characterization-and-antibacterial-activity
#4
T Cerchiara, A Abruzzo, R A Ñahui Palomino, B Vitali, R De Rose, G Chidichimo, L Ceseracciu, A Athanassiou, B Saladini, F Dalena, F Bigucci, B Luppi
In this work, we propose as new wound dressing, the Spanish Broom fibers impregnated with vancomycin (VM) loaded chitosan nanoparticles. Spanish Broom fibers were extracted by patented method DiCoDe and the morphological, physical and mechanical properties were investigated. Chitosan nanoparticles were prepared by ionic gelation using different weight ratios between chitosan (CH) and tripolyphosphate (TPP). Nanoparticles were characterized in terms of size, zeta potential, yield, encapsulation efficiency, stability and drug release...
December 5, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27931749/-hereditary-epidermolysis-bullosa-french-national-guidelines-pnds-for-diagnosis-and-treatment
#5
C Chiaverini, E Bourrat, J Mazereeuw-Hautier, S Hadj-Rabia, C Bodemer, J-P Lacour
Hereditary epidermolysis bullosa (EB) is a heterogeneous group of rare genetic diseases characterized by fragile skin and/or mucous membrane, and it may be either local or generalized. It is caused by mutations in genes encoding different proteins involved mainly in the structure and function of the dermal-epidermal junction. Nineteen genes have so far been identified. They are classified by level of skin cleavage (from top to bottom) into four groups: EB simplex, junctional EB, dystrophic EB and Kindler syndrome...
December 5, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27931171/-behaving-well-the-transition-to-respectable-womanhood-in-rural-south-africa
#6
Christie Sennott, Sanyu A Mojola
Few studies of the transition to adulthood in Africa analyse young people's own definitions of the events that confer adult status, and how adulthood is actually attained. This paper examines the experience of transitioning to womanhood in rural Mpumalanga Province, South Africa, drawing on interviews with 18 women aged 18-39. Three primary experiences characterised this transition: puberty and emerging body awareness, spending time with boys, and having a child. More important than the timing of these experiences, however, was whether women 'behaved well' and maintained respectability as they transitioned to adulthood...
December 9, 2016: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/27928911/soft-silicone-foam-dressing-is-more-effective-than-polyurethane-film-dressing-for-preventing-intraoperatively-acquired-pressure-ulcers-in-spinal-surgery-patients-the-border-operating-room-spinal-surgery-boss-trial-in-japan
#7
Mine Yoshimura, Norihiko Ohura, Junko Tanaka, Shoichi Ichimura, Yusuke Kasuya, Oruto Hotta, Yu Kagaya, Takuya Sekiyama, Mitsuko Tannba, Nao Suzuki
Preventing intraoperatively acquired pressure ulcers (IAPUs) in patients undergoing spinal surgery in the prone position using a Relton-Hall frame is challenging. We investigated the efficacy of soft silicone foam dressings in preventing IAPUs. A prospective dual-center sham study was conducted among patients undergoing elective spinal surgery in a general hospital and a university hospital in Japan. The incidence of IAPUs that developed when soft silicone foam dressings and polyurethane film dressings were used was compared on two sides in the same patient...
December 7, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27928511/latino-hispanic-alzheimer-s-caregivers-experiencing-dementia-related-dressing-issues-corroboration-of-the-preservation-of-self-model-and-reactions-to-a-smart-dresser-computer-based-dressing-aid
#8
Diane Feeney Mahoney, David W Coon, Cecil Lozano
OBJECTIVE: To gain an understanding of Latino/Hispanic caregivers' dementia-related dressing issues, their impressions of using a "smart" context-aware dresser to coach dressing, and recommendations to improve its acceptability. METHOD: The same Latina moderator conducted all the caregiver focus groups. She followed a semi-structured interview guide that was previously used with White and African American family caregivers who experienced Alzheimer's disease related dressing challenges...
November 2016: Digit Health
https://www.readbyqxmd.com/read/27926575/prophylactic-negative-pressure-dressing-use-in-closed-laparotomy-wounds-following-abdominal-operations-a-randomized-controlled-open-label-trial-the-p-i-c-o-trial
#9
Donal Peter O'Leary, Colin Peirce, Breffini Anglim, Marguerite Carter, Kevin Hickey, John Calvin Coffey
OBJECTIVE: A randomized controlled trial was undertaken to investigate the effect of prophylactic negative pressure dressings on postoperative surgical site infection (SSI) rates in closed laparotomy wounds. SUMMARY OF BACKGROUND DATA: Laparotomy wounds are associated with high rates of SSI. The effect of prophylactic negative pressure dressing of closed incisional wounds on SSI rate is unknown. METHODS: A randomized, controlled, open-label trial was conducted (clinicaltrials...
December 6, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27922792/wound-bed-preparation-a-novel-approach-using-hydrotherapy
#10
Leanne Atkin, Karen Ousey
Wounds that fail to heal quickly are often encountered by community nursing staff. An important step in assisting these chronic or stalled wounds progress through healing is debridement to remove devitalised tissue, including slough and eschar, that can prevent the wound from healing. A unique wound treatment called HydroTherapy aims to provide an optimal healing environment. The first step of HydroTherapy involves HydroClean plus™, this dressing enables removal of devitalised tissue through autolytic debridement and absorption of wound fluid...
December 2016: British Journal of Community Nursing
https://www.readbyqxmd.com/read/27922787/hydro-responsive-wound-dressings-simplify-t-i-m-e-wound-management-framework
#11
Karen Ousey, Alan A Rogers, Mark G Rippon
The development of wound management protocols and guidelines such as the T.I.M.E. acronym are useful tools to aid wound care practitioners deliver effective wound care. The tissue, infection/inflammation, moisture balance and edge of wound (T.I.M.E.) framework provides a systematic approach for the assessment and management of the majority of acute and chronic wounds. The debridement of devitalised tissue from the wound bed, the reduction in wound bioburden and effective management of wound exudate - i.e., wound bed preparation - are barriers to wound healing progression that are targeted by T...
December 2016: British Journal of Community Nursing
https://www.readbyqxmd.com/read/27922762/nonchemotherapy-drug-induced-agranulocytosis-in-children-detected-by-a-prospective-pharmacovigilance-program
#12
Nicolás Medrano-Casique, Hoi Y Tong, Alberto M Borobia, Antonio J Carcas, Jesús Frías, Elena Ramírez
OBJECTIVES: A prospective evaluation of nonchemotherapy drug-induced agranulocytosis (DIA) cases, which are infrequent in the pediatric population. We characterize agranulocytosis cases and assess lab test differences between drug- and nondrug-induced agranulocytosis. METHODS: Through our Prospective Pharmacovigilance Program from Laboratory Signals at Hospital we detected pediatric agranulocytosis cases from July 2007 to December 2010. This program estimates the incidence, drug causality, clinical features, outcomes of DIA pediatric cases, and assesses laboratory differences with respect to non-DIA...
December 6, 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27920572/home-peripheral-nerve-catheters-the-first-24-months-of-experience-at-a-children-s-hospital
#13
Andrew Gable, Candice Burrier, Jenna Stevens, Sharon Wrona, Kevin Klingele, Tarun Bhalla, David P Martin, Giorgio Veneziano, Joseph D Tobias
CONTEXT: Home peripheral nerve catheters (PNCs) have become common practice for adult patients after major orthopedic surgery. However, use in pediatric patients is a recent application. OBJECTIVES: The purpose of this study was to review the demographics and outcomes of pediatric patients receiving a PNC at our institution. METHODS: This retrospective study included patients from October 2012 through October 2014 undergoing orthopedic procedures with a PNC placed for postoperative pain management...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27919488/clinical-assessment-of-gait-in-individuals-with-multiple-sclerosis-using-wearable-inertial-sensors-comparison-with-patient-based-measure
#14
Massimiliano Pau, Silvia Caggiari, Alessandro Mura, Federica Corona, Bruno Leban, Giancarlo Coghe, Lorena Lorefice, Maria Giovanna Marrosu, Eleonora Cocco
BACKGROUND: This study aims to verify the feasibility of use of wearable accelerometers in an ambulatory environment to assess spatiotemporal parameters of gait in people with Multiple Sclerosis (pwMS), as well as the correlation of objective data with patient-reported outcomes. METHODS: One hundred and five pwMS (Expanded Disability Status Scale, EDSS in the range 0-6.5) classified in three sub-groups (EDSS 0-1.5, EDSS 2-4, EDSS 4.5-6.5) and 47 healthy controls (HC) participated in the study...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27916867/methods-of-synthesis-properties-and-biomedical-applications-of-cuo-nanoparticles
#15
REVIEW
Madalina Elena Grigore, Elena Ramona Biscu, Alina Maria Holban, Monica Cartelle Gestal, Alexandru Mihai Grumezescu
This study aims to provide an updated survey of the main synthesis methods of copper oxide (CuO) nanoparticles in order to obtain tailored nanosystems for various biomedical applications. The synthesis approach significantly impacts the properties of such nanoparticles and these properties in turn have a significant impact on their biomedical applications. Although not widely investigated as an efficient drug delivery system, CuO nanoparticles have great biological properties including effective antimicrobial action against a wide range of pathogens and also drug resistant bacteria...
November 30, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27916359/long-term-follow-up-of-fournier-s-gangrene-in-a-tertiary-care-center
#16
David R Rosen, Mitchell E Brown, Kyle G Cologne, Glenn T Ault, Aaron M Strumwasser
BACKGROUND: After surgical debridement, the use of fecal diversion systems (such as an endo-rectal tube or surgical colostomy) in Fournier's Gangrene (FG) to assist with wound healing remains controversial. METHODS: A 6-y retrospective review of a tertiary medical center emergency surgery database was conducted. Variables abstracted from the database include patient demographics, laboratory and physiological profiles, hospital length-of-stay, intensive care unit length-of-stay, operative data, time to healing, morbidity, and mortality...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27915402/an-easy-to-use-wound-dressing-gelatin-bioactive-nanoparticle-gel-and-its-preliminary-in-vivo-study
#17
Chen Wang, Feiyan Zhu, Yang Cui, Huihui Ren, Yue Xie, Ailing Li, Lijun Ji, Xiaozhong Qu, Dong Qiu, Zhenzhong Yang
Beyond promoting hard tissue repairing, bioactive glasses (BGs) have also been proved to be beneficial for wound healing. Nano-scale BGs prepared by sol-gel method were found to have a better performance as they have a larger specific surface area. In this work, bioactive nanoparticles (nBPs) with mean diameter of 12 nm (BP-12) instead of conventional BGs were mixed with gelatin to form an easy-to-use hydrogel as a dressing for skin wound. It was found that the composite of BP-12 and gelatin could form a hydrogel (BP-12/Gel) under 25 °C, which showed pronounced thixotropy at a practically accessible shear rate, therefore become easy to be used for wound cover...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27914965/a-review-on-synthesis-properties-and-applications-of-natural-polymer-based-carrageenan-blends-and-composites
#18
REVIEW
Khalid Mahmood Zia, Shazia Tabasum, Muhammad Nasif, Neelam Sultan, Nosheen Aslam, Aqdas Noreen, Mohammad Zuber
Carrageenan is a natural polysaccharide extracted from edible red seaweeds of Rhodophycea class. It has been used as a viscosity increasing or gelling agent for prolonged and controlled drug release, food, pharmaceuticals and other industries. However, in spite of wide range of applications, carrageenan has some drawbacks and adverse effects on the biological systems, so its modifications with natural and synthetic polymers are carried out. This review article presents different sources and properties of carrageenans with special emphasis on natural polymer based carrageenan blends and composites and their applications in controlled drug delivery system, wound dressing and tissue engineering because of their biodegradability and biocompatibility, food industry as thickening/gelling materials, cosmeceuticals and making polyelectrolyte complexes...
November 30, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27911904/dressing-wear-time-after-breast-reconstruction-a-randomized-clinical-trial
#19
Daniela Francescato Veiga, Carlos Américo Veiga Damasceno, Joel Veiga-Filho, Luiz Francisley Paiva, Fernando Elias Martins Fonseca, Isaías Vieira Cabral, Natália Lana Larcher Pinto, Yara Juliano, Lydia Masako Ferreira
BACKGROUND: The evidence to support dressing standards for breast surgery wounds is empiric and scarce. OBJECTIVE: This two-arm randomized clinical trial was designed to assess the effect of dressing wear time on surgical site infection (SSI) rates, skin colonization and patient perceptions. METHODS: A total of 200 breast cancer patients undergoing breast reconstruction were prospectively enrolled. Patients were randomly allocated to group I (dressing removed on the first postoperative day, n = 100) or group II (dressing removed on the sixth postoperative day, n = 100)...
2016: PloS One
https://www.readbyqxmd.com/read/27911553/arbitrary-dicke-state-control-of-symmetric-rydberg-ensembles
#20
Tyler Keating, Charles H Baldwin, Yuan-Yu Jau, Jongmin Lee, Grant W Biedermann, Ivan H Deutsch
We study the production of arbitrary superpositions of Dicke states via optimal control. We show that N atomic hyperfine qubits, interacting symmetrically via the Rydberg blockade, are well described by the Jaynes-Cummings Hamiltonian and fully controllable by phase-modulated microwaves driving Rydberg-dressed states. With currently feasible parameters, it is possible to generate states of ∼ten hyperfine qubits in ∼1  μs, assuming a fast microwave phase switching time. The same control can be achieved with a "dressed-ground control" scheme, which reduces the demands for fast phase switching at the expense of increased total control time...
November 18, 2016: Physical Review Letters
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