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https://www.readbyqxmd.com/read/29144890/comprehensive-analysis-of-patients-with-neuromyelitis-optica-spectrum-disorder-nmosd-combined-with-chronic-hepatitis-b-chb-infection-and-seropositive-for-anti-aquaporin-4-antibody
#1
Jia Liu, Li Xu, Zhuo-Lin Chen, Min Li, Huan Yi, Fu-Hua Peng
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody (AQP4-Ab). Demographic, clinical, laboratory, neuroimaging, outcome, and follow-up data of the 10 patients were retrospectively analyzed...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29144803/endocrine-manifestations-of-primary-hyperoxaluria
#2
Shatha Murad, Yuval Eisenberg
OBJECTIVE: Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder of oxalate overproduction. It is associated with urolithiasis and nephrocalcinosis which progress to ESRD and systemic oxalosis. As oxalate deposits in tissues, non-parathyroid hormone (nonPTH) mediated hypercalcemia, oxalate osteopathy, primary hypothyroidism and primary hypogonadism develop. In this review, we will present a case of PH1 and provide an overview of this clinical entity and its endocrine manifestations...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142833/the-effect-of-long-term-thyroid-stimulating-hormone-suppressive-therapy-on-the-gonadal-steroid-hormones-of-patients-with-thyroid-carcinoma-after-surgery
#3
Xiaoli Liu, Ying Zhou, Nan Liang, Yang Hong, Gianlorenzo Dionigi, Hui Sun
Background: To analyze the effect of long-term thyroid-stimulating hormone (TSH) suppressive therapy on the gonadal hormones and related symptoms in patients after surgery. Methods: From 2008 to 2011, totally 238 patients were recruited, who underwent thyroid surgery and subsequent TSH suppression treatment in Department of thyroid Surgery, China-Japan Union hospital, Jilin University. Then their postoperative follow-up data (3-8 years) were collected, including operational method, pathological diagnosis, whether processed radioiodine therapy and the period/dose of TSH suppression treatment...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29137069/graves-disease-following-radioiodine-therapy-for-toxic-adenoma-clinical-case-report
#4
Guohua Shen, Futao Cui, Rui Huang, Anren Kuang
RATIONALE: There is a low risk of developing Graves disease (GD) with elevated thyrotropin receptor antibodies (TRAbs) in patients undergoing radioiodine therapy for toxic adenoma. PATIENT CONCERNS: An old female patient with a history of Hashimoto thyroiditis was referred to our department due to thyrotoxic symptoms. After the administration of radioiodine, a significant remission was achieved. However, after 4 months, she was referred to our department again due to recurrence of hyperthyroid symptoms...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136674/familial-hyperparathyroidism-disorders-of-growth-and-secretion-in-hormone-secretory-tissue
#5
Stephen J Marx, Delmar Muniz Lourenco
Six syndromes of familial hyperparathyroidism are compared: 1) Familial hypocalciuric hypercalcemia (FHH) expresses primary hyperparathyroidism (PHPT) beginning at birth with lifelong hypercalcemia. There is nonsuppressed PTH secretion from outwardly normal parathyroid glands. It reflects germline heterozygous mutation in CASR, GNA11, or AP2S1. 2) Neonatal severe primary hyperparathyroidism is severest of the six syndromes. It requires urgent total parathyroidectomy in infancy. It usually reflects biallelic inactivation of the CASR...
November 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29135741/the-association-between-anti-thyroid-antibodies-and-quality-of-life-in-patients-with-thyroid-disorders-a-systematic-review-protocol
#6
Marion Patti, Robin Christian
The objective of this systematic literature review is to identify the association between anti-thyroid antibodies and quality of life in patients with thyroid disorders.
November 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29135488/endocrine-manifestations-of-down-syndrome
#7
Rachel Whooten, Jessica Schmitt, Alison Schwartz
PURPOSE OF REVIEW: To summarize the recent developments in endocrine disorders associated with Down syndrome. RECENT FINDINGS: Current research regarding bone health and Down syndrome continues to show an increased prevalence of low bone mass and highlights the importance of considering short stature when interpreting dual energy x-ray absorptiometry. The underlying cause of low bone density is an area of active research and will shape treatment and preventive measures...
November 11, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29135108/addressing-the-post-irradiation-hypothalamic-pituitary-endocrine-abnormalities-of-brain-tumors-in-pediatric-patients
#8
Louloudenia Velentza, Maria Tolia, Charikleia Christakou, Michail Nikolaou, Ioannis Zerdes, Nikolaos Tsoukalas, Jiannis Hajiioannou, Konstantinos Tsanadis, Georgios Rigas, Michail Mitsis, Kyriaki Theodorou, Kyriaki Pistevou-Gombaki, Periklis Tsekeris, George Kyrgias
PURPOSE: Hypothalamic-pituitary axis is susceptible to radiotherapy, causing endocrine disorders to childhood cancer survivors. We conducted a systematic review in order to assess the radiation-induced toxicity that leads to hormone secretion abnormalities and their severity in children with brain tumors. METHODS: The data were collected by relevant studies on PubMed and EMBASE. Articles up to December 2016 were included. We selected studies which focused on children patients (<18 yr old) with brain tumors treated with radiotherapy and the consequences for their endocrine system...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134650/thyroid-associated-genetic-polymorphisms-in-relation-to-breast-cancer-risk-in-the-malm%C3%A3-diet-and-cancer-study
#9
Jasmine Brandt, Signe Borgquist, Peter Almgren, Asta Försti, Linnea Huss, Olle Melander, Jonas Manjer
Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet and Cancer Study (a population-based prospective study consisting of 17,035 women) to examine 17 single nucleotide polymorphisms (SNPs) previously related to levels of free thyroxine (free T4) and thyroid peroxidase antibodies (TPO-Ab) as potential genetic risk factors for breast cancer...
November 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29133889/oral-exposure-to-dibutyl-phthalate-exacerbates-chronic-lymphocytic-thyroiditis-through-oxidative-stress-in-female-wistar-rats
#10
Yang Wu, Jinquan Li, Biao Yan, Yuqing Zhu, Xudong Liu, Mingqing Chen, Dai Li, Ching-Chang Lee, Xu Yang, Ping Ma
Chronic lymphocytic thyroiditis (CLT) is a common autoimmune disorder. The possible pathogenic role and mechanism of dibutyl phthalate (DBP) in CLT is still controversial. Experiments were conducted after 35-days of oral exposure to the three concentrations of DBP or saline, and three immunizations with thyroglobulin (TG). Healthy female Wistar rats were randomly divided into ten exposure groups (n = 8 each): (A) saline control, (B) 0.5 mg/kg/d DBP, (C) 5 mg/kg/d DBP, (D) 50 mg/kg/d DBP, (E) TG-immunized group, (F) TG- combined with 0...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131924/when-an-orbital-infection-isn-t-infectious-at-all-a-review-of-orbital-inflammatory-syndrome
#11
Sadie A LaPonsie, Peter K Rabiah
Orbital inflammatory syndrome (OIS) includes a wide range of clinical manifestations and may initially be misdiagnosed as orbital cellulitis due similar symptoms of fever, periorbital swelling, and pain with eye movements. A diagnosis of OIS requires evaluation for underlying systemic disorders including autoimmune disorders and thyroid disease. Symptoms typically improve rapidly after initiation of steroid therapy, although recurrence can occur. This article presents an illustrative case of a 13-year-old girl with OIS...
November 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29131489/evaluation-of-the-serum-zinc-level-in-adult-patients-with-melasma-is-there-a-relationship-with-serum-zinc-deficiency-and-melasma
#12
Majid Rostami Mogaddam, Nastaran Safavi Ardabili, Manouchehr Iranparvar Alamdari, Nasrollah Maleki, Maryam Aghabalaei Danesh
BACKGROUND: Melasma is a common acquired hypermelanosis of sun-exposed skin, particularly on the face, which presents as symmetric, light- to gray-brown-colored macules and patches. There are several studies of serum zinc levels in cutaneous disorders. So far, no studies have been carried out to assess the serum zinc level in patients with melasma. The aim of this study is to determine the serum zinc level in patients with melasma compared to healthy subjects. MATERIALS AND METHODS: A total of 118 patients with melasma and 118 healthy controls were enrolled in this prospective cross-sectional study...
November 12, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29128804/hexachlorobenzene-as-a-persistent-organic-pollutant-toxicity-and-molecular-mechanism-of-action
#13
REVIEW
Beata Starek-Świechowicz, Bogusława Budziszewska, Andrzej Starek
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. Chronic exposure of humans to HCB leads to a number of effects, such as triggering of porphyria, microsomal enzyme induction, thyroid dysfunctions, neurological symptoms, and immunological disorders. In animals, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the thyroid function, reproductive system, and immune system. HCB as a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) is a hormonal disruptor...
July 1, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128434/the-korean-version-of-the-voice-symptom-scale-for-patients-with-thyroid-operation-and-its-use-in-a-validation-and-reliability-study
#14
Hee Young Son, Chang-Yoon Lee, Kyung A Kim, Sina Kim, Hee Seok Jeong, Jin Pyeong Kim
OBJECTIVES: The Voice Symptom Scale (VoiSS) questionnaire is a self-reported measure of voice function. Compared with previous voice-rating tools, the VoiSS focuses more on communication difficulties, pharyngeal symptoms, and psychosocial distress. This study aimed to translate the VoiSS into the Korean language, validate it, and assess its reliability. STUDY DESIGN: This is a prospective patient study utilizing questionnaires and acoustic analysis. METHODS: A recognized methodology was used to translate the questionnaires...
November 8, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29120649/-thyroid-disease-in-the-czech-republic-the-euthyroid-project-and-the-evaluation-of-the-general-health-insurance-company-epidemiological-data-for-the-period-of-2012-2015
#15
Radovan Bílek, Lenka Horáková, Robert Goš, Václav Zamrazil
Institute of Endocrinology participates in the grant of European Commission EUthyroid (Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe), together with other 28 European countries. The role of Institute of Endocrinology in EUthyroid is among other things to ensure access to national registers relating to thyroid diseases. The results presented here correspond to the years 2012-2015 and are based on data from the General Health Insurance Company Czech Republic (VZP CR), which has 6 million insured persons (ratio male : female = 1 : 1)...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29119329/a-functional-assessment-of-anatomical-variants-of-the-recurrent-laryngeal-nerve-during-thyroidectomies-using-neuromonitoring
#16
Beata Wojtczak, Krzysztof Kaliszewski, Krzysztof Sutkowski, Marek Bolanowski, Marcin Barczyński
PURPOSE: The aim of the study was to assess the usefulness of intraoperative neuromonitoring (IONM) in identifying anatomical variants of the recurrent laryngeal nerve (RLN) during thyroidectomies, with emphasis on the nerve's relationship to the inferior thyroid artery (ITA), Zuckerkandl's tubercle, nonrecurrent laryngeal nerves (NRLNs), and extralaryngeal bifurcation. METHODS: A total of 128 subjects undergoing surgery for thyroid disorders were enrolled in the study, and the course and anatomical variants of RLN were assessed with IONM application...
November 8, 2017: Endocrine
https://www.readbyqxmd.com/read/29113155/poems-syndrome-presentation-with-progressive-weakness-in-upper-and-lower-limbs-a-case-report
#17
Chuang-Jie Cao, Cheng-Yun Dou, Ke-Hua Zhou, Jin-Bo Liu, Hong Lai
Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS) syndrome is a rare variant of plasma cell disorders with multiple systemic manifestations. A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typicallyλ-restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin B12 and weight loss...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29111262/overcoming-monocarboxylate-transporter-8-mct8-deficiency-to-promote-human-oligodendrocyte-differentiation-and-myelination
#18
Jae Young Lee, Min Joung Kim, Devy Deliyanti, Michael F Azari, Fernando Rossello, Adam Costin, Georg Ramm, Edouard G Stanley, Andrew G Elefanty, Jennifer L Wilkinson-Berka, Steven Petratos
Cell membrane thyroid hormone (TH) transport can be facilitated by the monocarboxylate transporter 8 (MCT8), encoded by the solute carrier family 16 member 2 (SLC16A2) gene. Human mutations of the gene, SLC16A2, result in the X-linked-inherited psychomotor retardation and hypomyelination disorder, Allan-Herndon-Dudley syndrome (AHDS). We posited that abrogating MCT8-dependent TH transport limits oligodendrogenesis and myelination. We show that human oligodendrocytes (OL), derived from the NKX2.1-GFP human embryonic stem cell (hESC) reporter line, express MCT8...
October 19, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29109906/the-movement-disorder-of-brain-lung-thyroid-syndrome-can-be-responsive-to-methylphenidate
#19
Laurence Gauquelin, Luan T Tran, Sylvain Chouinard, Geneviève Bernard
No abstract text is available yet for this article.
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29102897/the-hypothalamic-pituitary-thyroid-axis-and-personality-in-a-sample-of-healthy-subjects
#20
Aleksei Piskunov, Adela Fusté, Nadezhda Teryaeva, Aleksei Moshkin, José Ruiz
Thyroid hormones influence various brain pathologies, including psychiatric disorders. However, the relationship between these hormones and the psychological state in the normal, non-clinical population is poorly understood. We aimed to test whether serum levels of thyroid hormones are associated with personality in the healthy population. Thyrotropin (TSH), free T3 (FT4), total and free T4 (TT4 and FT4) concentrations were measured in the blood of 104 healthy participants (44% men) aged 18-59 (M=35±9). Personality traits were assessed using the revised short versions of the Temperament and Character Inventory (TCI-140) and the NEO Five-Factor Inventory (NEO-FFI)...
October 31, 2017: Psychoneuroendocrinology
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