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White dot syndrom

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https://www.readbyqxmd.com/read/28728181/the-value-of-diagnostic-work-up-in-the-evaluation-of-white-dot-syndromes
#1
Neal V Palejwala, Gagan Sawhney, Matthew Raecker, Chrstina J Flaxel, Steven Yeh
BACKGROUND AND OBJECTIVE: To determine the diagnostic yield of systemic work-up in white dot syndromes. PATIENTS AND METHODS: A retrospective chart review. RESULTS: Eighty-six consecutive patients with a diagnosis of a white dot syndrome were identified. Forty-three had a diagnosis of birdshot chorioretinopathy. Overall, 395 diagnostic tests were performed with a diagnostic yield of 11.9%. The test with the greatest diagnostic yield was HLA-A29 typing (89%)...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28686185/the-roles-of-%C3%AE-integrin-of-chinese-shrimp-fenneropenaeus-chinensis-in-wssv-infection
#2
Xiaoqian Tang, Fude Zhai, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
Our previous study demonstrated that an integrin β subunit of Chinese shrimp (Fenneropenaeus chinensis) (FcβInt) plays an important role in white spot syndrome virus (WSSV) infection. In the present work, in order to further elucidate the potential role of FcβInt in WSSV infection, the recombinant extracellular domain of β integringene of F. Chinensis (rFcβInt-ER) was expressed in Escherichia coli BL21 (DE3), and the eukaryotic expression plasmid PcDNA3.1-FcβInt-ER (PFcβInt-ER) was also constructed. Far-western blotting was performed to determine the binding specificity of rFcβInt-ER to WSSV envelope proteins, and results showed that rFcβInt-ER was able to specifically interact with rVP31, rVP37, rVP110 and rVP187...
July 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28614139/multiple-evanescent-white-dot-syndrome-with-subretinal-deposits
#3
Orly Gal-Or, John A Sorenson, Sarra Gattoussi, Rosa Dolz-Marco, K Bailey Freund
PURPOSE: To describe the multimodal imaging findings of transient subretinal deposits occurring in multiple evanescent white dot syndrome (MEWDS). METHODS: The multimodal imaging characteristics of transient subretinal deposits occurring in MEWDS were investigated with ultra-widefield color and fundus autofluorescence, cross-sectional and en-face optical coherence tomography (OCT), en face OCT-angiography, and quantitative autofluorescence. RESULTS: A 28-year-old woman presented with photopsia and temporal visual field loss in her right eye...
June 13, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28584665/multimodal-imaging-in-an-unusual-cluster-of-multiple-evanescent-white-dot-syndrome
#4
Orly Gal-Or, Ethan Priel, Irit Rosenblatt, Shiri Shulman, Michal Kramer
OBJECTIVE: To describe an unusual cluster of multiple evanescent white dot syndrome (MEWDS) encountered within a 3-month period. METHODS: This retrospective observation study is comprised of seven patients who presented with MEWDS in a 3-month period in central Israel. Data were collected from patients' medical records on clinical, multimodal imaging, and viral serology findings. RESULTS: Six women and one man of mean age 31.5 ± 7.2 years...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28511857/posterior-microphthalmos-retinitis-pigmentosa-and-optic-disc-drusen-with-white-dots-a-case-report
#5
P Plaza, O Iturralde, C Abascal
OBJECTIVE: To present the case of a patient with a posterior microphthalmos-optic disc drusen-retinitis pigmentosa syndrome associated, for the first time, with white dots in the posterior pole. METHODOLOGY: The posterior microphthalmos, retinitis pigmentosa and optic disc drusen syndrome was described for the first time in literature in 1991. Later, it was associated with a pattern of foveal thickening and/or foveoschisis. Different forms of mutations on chromosomes 11 and 14 have been identified as being responsible for the appearance of this syndrome, but the inheritance pattern is unknown...
May 13, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28465249/the-application-of-optical-coherence-tomography-angiography-in-uveitis-and-inflammatory-eye-diseases
#6
REVIEW
Francesco Pichi, David Sarraf, Sruthi Arepalli, Careen Y Lowder, Emmett T Cunningham, Piergiorgio Neri, Thomas A Albini, Vishali Gupta, Kimberly Baynes, Sunil K Srivastava
Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse...
April 29, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28459297/regarding-comments-by-mathis-t-and-kodjikian-l-on-choroidal-neovascularization-associated-with-multiple-evanescent-white-dot-syndrome-treated-with-intravitreal-ranibizumab
#7
Maurizio Battaglia Parodi, Pierluigi Iacono, Ilaria Zucchiatti, Francesco Bandello
No abstract text is available yet for this article.
May 1, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28453367/retinal-pigment-epithelium-photoreceptor-layer-alterations-in-a-patient-with-sturge-weber-syndrome-with-diffuse-choroidal-hemangioma
#8
Solmaz Abdolrahimzadeh, Francesco Parisi, Flavio Mantelli, Andrea Perdicchi, Gianluca Scuderi
PURPOSE: To describe an 8-year-old girl with diagnosis of Sturge-Weber syndrome (SWS) presenting with glaucoma, abnormal iris vessels, diffuse choroidal hemangioma, and small white dot-shaped "microdrusen-like" alterations of the retina in the right eye. PATIENT AND METHODS: Complete ophthalmological examination was performed with slit-lamp anterior segment assessment and fundus ophthalmoscopy. Near infrared reflectance (NIR) and enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT) were carried out...
April 28, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28448735/in-response-to-parodi-mb-iacono-p-zucchiatti-et-al-choroidal-neovascularization-associated-with-multiple-evanescent-white-dot-syndrome-treated-with-intravitreal-ranibizumab
#9
Thibaud Mathis, Laurent Kodjikian
In response to the article by Parodi et al. about choroidal neovascularization (CNV) associated with Multiple Evanescent White Dot Syndrome (MEWDS) treated with intravitreal Ranibizumab. This article highlights the efficacy of intravitreal Ranibizumab in the treatment of CNV associated with MEWDS. In our experience, CNV is mostly associated with MEWDS in cases of a wider inflammatory spectrum such as overlapping syndrome with multifocal choroiditis (MFC) or punctuate inner choroidopathy (PIC). The whole pattern of the case presented in the article is compatible with the diagnosis of PIC, meaning that this case described an overlapping between MEWDS and PIC diagnoses...
April 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28374276/recurrent-focal-choroidal-excavation-following-multiple-evanescent-white-dot-syndrome-mewds-associated-with-acute-idiopathic-blind-spot-enlargement
#10
Mohammad Hossein Jabbarpoor Bonyadi, Kiana Hassanpour, Masoud Soheilian
PURPOSE: To present a recurrent case of conforming focal choroidal excavation (FCE) following multiple evanescent white dot syndrome (MEWDS) in a 25-year-old woman. METHODS: Following spontaneous MEWDS sings resolution our patient noted a recurrent decrease in vision. Repeated OCT revealed elevation and mild disruption of RPE layer at fovea without previous angiographic MEWDS signs. At this time, short-term systemic steroid therapy was started and visual acuity became normal...
April 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28331634/multi-modal-imaging-and-anatomic-classification-of-the-white-dot-syndromes
#11
REVIEW
Meisha L Raven, Alexander L Ringeisen, Yoshihiro Yonekawa, Maxwell S Stem, Lisa J Faia, Justin L Gottlieb
The white dot syndromes (WDS) are a diverse group of posterior uveitidies that share similar clinical findings but are unique from one another. Multimodal imaging has allowed us to better understand the morphology, the activity and age of lesions, and whether there is CNV associated with these different ocular pathologies. The "white dot syndromes" and their uveitic masqueraders can now be anatomically categorized based on lesion localization. The categories include local uveitic syndromes with choroidal pathology, systemic uveitic syndromes with choroidal pathology, and multifocal choroiditis with outer retinal/choriocapillaris pathology with uveitis and without uveitis...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28253223/observation-and-clinical-pattern-in-patients-with-white-dot-syndromes-the-role-of-color-photography-in-monitoring-ocular-changes-in-long-term-observation
#12
Joanna Brydak-Godowska, Joanna Gołębiewska, Monika Turczyńska, Joanna Moneta-Wielgoś, Agnieszka Samsel, Piotr K Borkowski, Michał Ciszek, Agnieszka Płonecka-Rodzoch, Aleksandra Kużnik-Borkowska, Joanna Ciszewska, Elżbieta Makomaska-Szaroszyk, Lidia B Brydak, Dariusz Kęcik
BACKGROUND The aim of this study was to assess the clinical course and distinctive features of different white dot syndromes (WDS) in patients attending the Ophthalmology Department, Medical University of Warsaw in the years 1995-2015. MATERIAL AND METHODS Sixty-two (62) patients (43 females and 19 males), aged 18 to 77 years, referred with a WDS were included in this prospective study, with observation period ranging from 5 months to 16 years. All patients underwent a complete ophthalmological examination and multimodal imaging studies...
March 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28202480/multimodal-imaging-findings-in-hyper-early-stage-mewds
#13
Armelle Cahuzac, Benjamin Wolff, Thibaud Mathis, Marie-Hélène Errera, José-Alain Sahel, Martine Mauget-Faÿsse
OBJECTIVE: To describe a new stage of multiple evanescent white dot syndrome (MEWDS), occurring at a very early phase of the disease. METHODS: Retrospective analysis of clinical, angiographic and tomographic findings in four patients with 'hyper-early' stage MEWDS. RESULTS: In four patients seen within 1 week of the onset of symptoms, fundus analysis revealed macular granity and the classic yellow-white dots, some having no corresponding hyperautofluorescent pattern...
February 15, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28111793/dermoscopy-of-papular-epidermal-nevus-with-skyline-basal-cell-layer
#14
Riccardo Balestri, Laura Rizzoli, Giulia Rech, Carlo Renè Girardelli
Papular epidermal nevus with skyline basal cell layer (PENS) is a newly described keratinocytic nevus whose dermoscopic characteristics have not been clarified. We used a dermatoscope to investigate the multiple PENSs of a patient with PENS syndrome. All the lesions shared a common dermoscopic homogeneous white pattern surrounded by peripheral, slightly dotted hyperpigmentation. The smallest lesions had no other features, whereas the largest lesions had some scaling, directly proportional to their dimension, and a central, clear, pink discoloration...
March 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28098736/foveal-exudate-and-choroidal-neovascularization-in-atypical-cases-of-multiple-evanescent-white-dot-syndrome
#15
Kevin C Chen, Marcela Marsiglia, Rosa Dolz-Marco, Sarwar Zahid, Sarah Mrejen, Jose S Pulido, Salomon Y Cohen, Benjamin Freilich, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe atypical cases of multiple evanescent white dot syndrome (MEWDS) associated with foveal exudation, increased choroidal thickness, and secondary Type 2 (subretinal) neovascularization. METHODS: Four cases of atypical MEWDS were studied at a retina referral center. Patients underwent evaluation with multimodal retinal imaging, including fluorescein angiography, indocyanine green angiography, spectral-domain and enhanced depth imaging optical coherence tomography (OCT)...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28060397/swept-source-oct-angiography-shows-sparing-of-the-choriocapillaris-in-multiple-evanescent-white-dot-syndrome
#16
Nicolas A Yannuzzi, Swarup S Swaminathan, Fang Zheng, Andrew Miller, Giovanni Gregori, Janet L Davis, Philip J Rosenfeld
Two women with unilateral vision loss from multiple evanescent white dot syndrome were imaged serially with swept-source optical coherence tomography (SS-OCT). En face wide-field structural images revealed peripapillary outer photoreceptor disruption better than conventional fundus autofluorescence imaging. OCT angiography (OCTA) imaging showed preservation of flow within the retinal vasculature and choriocapillaris. As OCTA imaging of the choriocapillaris continues to evolve, these images may lay the groundwork for future investigation...
January 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28058168/a-case-of-lyme-disease-accompanied-by-uveitis-and-white-dot-syndrome
#17
İlkay Kılıç Müftüoğlu, Yonca Aydın Akova, Sirel Gür Güngör
In this case report we aimed to present a case of Lyme disease presenting as peripheral retinal vasculitis, intermediate uveitis and multifocal white dots in the posterior pole. The patient exhibited vitritis and snowball opacities in both eyes. A diagnosis of Lyme disease was made based on clinical, angiographic and laboratory findings. Fundus fluorescein angiography revealed optic nerve and retinal venous leakage as well as multiple hyperfluorescent foci in both eyes. The patient's symptoms and ocular findings significant improved after treatment with a combination of systemic antibiotics and steroids...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28005676/en-face-optical-coherence-tomography-and-optical-coherence-tomography-angiography-of-multiple-evanescent-white-dot-syndrome-new-insights-into-pathogenesis
#18
MULTICENTER STUDY
Francesco Pichi, Sunil K Srvivastava, Saradha Chexal, Andrea Lembo, Luiz H Lima, Piergiorgio Neri, Andrea Saitta, Jay Chhablani, Thomas A Albini, Paolo Nucci, K Bailey Freund, Hyewon Chung, Careen Y Lowder, David Sarraf
PURPOSE: To localize the various levels of abnormalities in multiple evanescent white dot syndrome by comparing "en face" optical coherence tomography (OCT) and OCT angiography with various conventional imaging modalities. METHODS: In this retrospective case series, multimodal imaging was performed in 9 retinal centers on 36 patients with multiple evanescent white dot syndrome and included widefield fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography, and B-scan and "en face" C-scan enhanced depth imaging and spectral domain OCT...
December 2016: Retina
https://www.readbyqxmd.com/read/27920655/deep-vein-thrombosis-as-initial-manifestation-of-whipple-disease
#19
Mônica Souza de Miranda Henriques, Alexandre Rolim da Paz, Ana Beatriz Person Gaertner, Cibelle Ingrid Stephen Melo, Priscyanne Lins Filgueiras, Rafaella Alencar Jerome
INTRODUCTION: Wipple disease (WD) is a rare chronic disease caused by the bacillus Tropheryma whipplei. Constitutive, rheumatologic, gastrointestinal, cardiac, cerebral, lymphatic, cutaneous, and ophthalmological signs are possible systemic symptoms. However, thrombotic manifestations are rarely described as "stroke-like syndrome" or arterial thrombosis. Diagnosis is based on clinical manifestations and pathological examination. Laboratory findings may include anemia, leukocytosis, and thrombocytosis...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27892746/choroidal-neovascularization-associated-with-multiple-evanescent-white-dot-syndrome-treated-with-intravitreal-ranibizumab
#20
Maurizio Battaglia Parodi, Pierluigi Iacono, Ilaria Zucchiatti, Francesco Bandello
PURPOSE: To describe the clinical outcomes of intravitreal ranibizumab treatment for subfoveal choroidal neovascularization (CNV) associated with multiple evanescent white dot syndrome (MEWDS). METHODS: This is a prospective, interventional, case series. All recruited patients underwent a baseline intravitreal ranibizumab injection and were monitored monthly over a 12-month follow-up, following a pro-re-nata regimen. RESULTS: Four patients (four eyes) were included in the study...
November 28, 2016: Ocular Immunology and Inflammation
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