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White dot syndrom

Dana Ahnood, Savitha Madhusudhan, Marie D Tsaloumas, Nadia K Waheed, Pearse A Keane, Alastair K Denniston
Punctate Inner Choroidopathy (PIC), an idiopathic inflammatory multifocal chorioretinopathy that predominantly affects young myopic women, appears to be relatively rare, but there is limited data to support accurate estimates of prevalence, and it is likely that the condition is under-diagnosed. The etiological relationship between PIC and other conditions within the 'white dot syndromes' group remains uncertain. We, like others, would suggest that PIC and multifocal choroiditis with panuveitis (MCP) represent a single disease process that is modified by host factors (including host immunoregulation) to cause the range of clinical phenotypes seen...
October 14, 2016: Survey of Ophthalmology
Tito Fiore, Barbara Iaccheri, Alessio Cerquaglia, Marco Lupidi, Giovanni Torroni, Daniela Fruttini, Carlo Cagini
PURPOSE: To perform an analysis of optical coherence tomography (OCT) abnormalities in patients with MEWDS, during the acute and recovery stages, using enhanced depth imaging-OCT (EDI-OCT). METHODS: A retrospective case series of five patients with MEWDS was included. EDI-OCT imaging was evaluated to detect retinal and choroidal features. RESULTS: In the acute phase, focal impairment of the ellipsoid zone and external limiting membrane, hyperreflective dots in the inner choroid, and full-thickness increase of the choroidal profile were observed in the affected eye; disappearance of these findings and restoration of the choroidal thickness (p = 0...
October 11, 2016: Ocular Immunology and Inflammation
Alain Gaudric, Sarah Mrejen
PURPOSE: To determine what retinal layer is primarily involved in multiple evanescent white dot syndrome compared with acute posterior multifocal placoid pigment epitheliopathy using multimodal imaging including indocyanine green angiography. METHODS: Color fundus photographs and fluorescein angiography, ICGA and spectral domain optical coherence tomography images of two typical acute cases, one of acute posterior multifocal placoid pigment epitheliopathy and one of multiple evanescent white dot syndrome, were assessed and compared...
September 21, 2016: Retinal Cases & Brief Reports
James P Dunn
No abstract text is available yet for this article.
2016: International Ophthalmology Clinics
Francesco Pichi, Sunil K Srvivastava, Saradha Chexal, Andrea Lembo, Luiz H Lima, Piergiorgio Neri, Andrea Saitta, Jay Chhablani, Thomas A Albini, Paolo Nucci, K Bailey Freund, Hyewon Chung, Careen Y Lowder, David Sarraf
PURPOSE: To localize the various levels of abnormalities in multiple evanescent white dot syndrome by comparing "en face" optical coherence tomography (OCT) and OCT angiography with various conventional imaging modalities. METHODS: In this retrospective case series, multimodal imaging was performed in 9 retinal centers on 36 patients with multiple evanescent white dot syndrome and included widefield fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography, and B-scan and "en face" C-scan enhanced depth imaging and spectral domain OCT...
August 22, 2016: Retina
Alfredo Pece, Davide Allegrini, Stelios Kontadakis, Giuseppe Querques, Luca Rossetti
BACKGROUND: To report a patient with angioid streaks (ASs) and coincident multiple evanescent white dot syndrome (MEWDS) who developed choroidal neovascularization (CNV). CASE PRESENTATION: A 20-year-old woman presented with reduced vision (20/100) in her left eye (LE). Based on a complete ophthalmologic examination the patient was diagnosed with ASs and coincident MEWDS. Two weeks later best-corrected visual acuity (BCVA) improved up to 20/25 and the MEWDS findings almost disappeared...
2016: BMC Ophthalmology
Polina Astroz, Sarah Mrejen, Eric H Souied, Camille Jung, Salomon Y Cohen
PURPOSE: To assess the influence of tilted disk syndrome (TDS) and inferior staphyloma on the macular clinical expression of MFC. METHODS: Medical charts of patients with MFC examined since 2009 were reviewed retrospectively. All patients underwent standard examination and multimodal imaging including fundus color photography, fundus autofluorescence, and spectral domain optical coherence tomography. Two groups of patients were compared : Group 1 with TDS and inferior staphyloma and Group 2 without...
July 1, 2016: Retina
A Stepanov, J Studnička, L Hejsek, J Dusová, N Jirásková
UNLABELLED: Punctate Inner Choroidopathy (PIC) is a rare idiopathic ocular inflammatory disease. It occurs mostly in young, myopic, otherwise healthy women. Symptoms of the disease include acute vision decrease associated with central and paracentral scotoma. In 80% of cases PIC occur bilaterally. We report the case of a woman at the age of twenty-five, who was treated for PIC. Due to the finding of active inflammatory deposit in the retina of the left eye and low visual acuity was recommended corticosteroid therapy with a good therapeutic effect...
2016: Ceská a Slovenská Oftalmologie
Miho Nozaki, Satoshi Hamada, Masayo Kimura, Munenori Yoshida, Yuichiro Ogura
This report describes a 19-year-old patient with the rare association of multiple evanescent white dot syndrome (MEWDS) and choroidal neovascularization (CNV). Despite the initial diagnosis of MEWDS, her vision significantly decreased. Fluorescein angiography showed dye leakage and pooling at the macula, whereas optical coherence tomography (OCT) showed cystoid macular edema and serous neuroepithelial elevation. The dye leakage and pooling made it impossible to diagnose CNV. However, OCT angiography (OCTA) revealed a vascular structure in the outer retina, thereby leading to the CNV diagnosis...
June 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Francesco Pellegrini, Emanuela Interlandi
A 25-year-old female presented to a local hospital for acute onset of a central scotoma in the left visual field. She was visited by the neurologist, and a diagnosis of left retrobulbar optic neuritis was made. Magnetic resonance imaging scan was normal. Ophthalmic examination revealed a multiple evanescent white dot syndrome. After a description of the case, a brief differential diagnosis between these two entities is made. The neurologist should be aware of this uncommon condition.
April 2016: Journal of Neurosciences in Rural Practice
Silvia Sale, Addolorata Emanuela Carone, Maurizio Fumi, Ylenia Pancione, Vincenzo Rocco
BACKGROUND: The infectious mononucleosis (IM) includes clue elements, apoptotic and atypical lymphocytes. In IM, the evaluation of dot plot provided by Sysmex XN-1000 analyzer revealed a stretched lymphocytic cluster, white cell differential channel (WDF), on cytogram. METHODS: In this study, we analyzed 698 samples that include 39 IM, 76 chronic lymphoproliferative disorders, 25 nonclonal lymphocytosis, and 40 healthy donors. Five hundred eighteen samples with other diseases or interference were evaluated...
September 2016: Journal of Clinical Laboratory Analysis
João Beato, Luís Fígueira, Susana Penas, Renato Santos-Silva, Manuel Falcão, Ângela Carneiro, Fernando Falcão Reis
PURPOSE: To report a presumed case of bilateral asynchronous cilioretinal occlusion associated with white dot syndrome. METHODS: A 19-year-old woman presented with decreased vision in the right eye. Cilioretinal occlusion was diagnosed and multimodal imaging was performed. RESULTS: Laboratory workup was negative. Fluorescein and indocyanine green angiography revealed an inflammatory choroidopathy in the right eye. Spectral-domain coherence tomography (OCT) initially showed internal retinal layer edema followed by atrophy in the papillomacular bundle...
2016: European Journal of Ophthalmology
A Chebil, Y Falfoul, I Habibi, F Munier, D Schorderet, L El Matri
PURPOSE: To evaluate the clinical phenotype of ten Tunisian families with non-syndromic retinitis pigmentosa (RP), to characterize genes and mutations causing these conditions, and to elaborate phenotype-genotype correlations. METHODS: Descriptive clinical genetic study of 114 individuals, of whom 27 are affected by non-syndromic RP. Ophthalmic examination and various visual tests were performed. DNA was analyzed using single nucleotide polymorphism, microsatellite genotyping and direct sequencing to determine the genes and mutations involved...
March 2016: Journal Français D'ophtalmologie
Kristin S Suhr, Michael F Chiang, John T Flynn, Michael Engelbert
PURPOSE: Hemophagocytic syndrome (HS) is a rare disease with a spectrum of ocular findings. The authors report a unique funduscopic presentation of HS in a neonate and a discussion of diagnosis, typical features, management, and outcome. METHODS: Single case report with retrospective analysis of the published literature of patients with HS and ocular findings from 1950 to present using the key terms hemophagocytic, lymphohistiocytosis, ocular, and ophthalmic. Literature search from 1950 to the present was performed through PubMed/MEDLINE and the Cochrane database...
October 2016: Retinal Cases & Brief Reports
Leanne T Labriola, Andrew D Legarreta, John E Legarreta, Zach Nadler, Denise Gallagher, Daniel X Hammer, R Daniel Ferguson, Nicusor Iftimia, Gadi Wollstein, Joel S Schuman
PURPOSE: To elucidate the location of pathological changes in multiple evanescent white dot syndrome (MEWDS) with the use of multimodal adaptive optics (AO) imaging. METHODS: A 5-year observational case study of a 24-year-old female with recurrent MEWDS. Full examination included history, Snellen chart visual acuity, pupil assessment, intraocular pressures, slit lamp evaluation, dilated fundoscopic exam, imaging with Fourier-domain optical coherence tomography (FD-OCT), blue-light fundus autofluorescence (FAF), fundus photography, fluorescein angiography, and adaptive-optics optical coherence tomography...
2016: Retinal Cases & Brief Reports
Kazuki Kuniyoshi, Hiroyuki Sakuramoto, Koji Sugioka, Chota Matsumoto, Shunji Kusaka, Yoshikazu Shimomura
To report the light- and dark-adapted perimetric findings in a patient with multiple evanescent white dot syndrome (MEWDS). The patient was a 25-year-old Japanese woman who underwent comprehensive ophthalmological examinations including measurements of the visual acuity, dilated ophthalmoscopy, Goldmann kinetic perimetry, electroretinography (ERG), indocyanine green fundus angiography (ICGA), and optical coherence tomography (OCT). Kinetic perimetry was performed under light- and dark-adapted conditions. The patient was diagnosed with MEWDS by the fundus and visual field findings, and the ICGA abnormalities...
August 2016: International Ophthalmology
Alessandro Mantovani, Andrea Giani, Carl P Herbort, Giovanni Staurenghi
PURPOSE: We aimed to describe imaging findings in primary inflammatory choriocapillaropathies (PICCPs) after a photobleaching process. METHODS: 2Images from six consecutive cases of patients affected by PICCPs (four with multiple evanescent white dot syndrome and two with multifocal choroiditis) were reviewed. Patients underwent fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), and spectral-domain optical coherence tomography (SD-OCT) by means of the Spectralis HRA (Heidelberg Engineering, Heidelberg, Germany)...
August 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Fred K Chen, Rian D Viljoen, Danuta M Bukowska
BACKGROUND: To evaluate and classify image artefacts in optical coherence tomography (OCT) angiography (OCTA) of the choroid in a group of patients with macular diseases. DESIGN: Retrospective observational study. PARTICIPANTS: Five patients with age-related macular degeneration, three with central serous retinopathy, one with polypoidal choroidal vasculopathy and one with multiple evanescent white dot syndrome. METHODS: OCTA and OCT reflectivity (OCTR) maps were reviewed along with their fluorescein angiography and indocyanine green angiography...
July 2016: Clinical & Experimental Ophthalmology
Akihiro Takahashi, Wataru Saito, Yuki Hashimoto, Susumu Ishida
PURPOSE: A recent study revealed thickening of the inner retinal layers in acute stage of multiple evanescent white dot syndrome (MEWDS); however, the pathogenesis is still unknown. We report two cases with MEWDS whose funduscopy showed obvious retinal vasculitis. METHODS: Case reports. RESULTS: Healthy myopic 16- and 27-year-old women were the cases under study. In both cases, funduscopic examination revealed multiple, faint, small, subretinal white dots at the posterior pole to the midperiphery and macular granularity oculus dexter...
2015: International Medical Case Reports Journal
Lillian Abreu Dias, Eduardo H Morizot
PURPOSE: To characterize multiple evanescent white dot syndrome (MEWDS)-like lesions as diagnosed by clinical exam and fluorescein angiography (FA) to build an epidemiological profile of this disease and highlight the most common angiographical aspects. It is important to emphasize the existence of this syndrome and improve patients' information about the natural good course of this disease. METHODS: A cross-sectional study including all FA performed from July 2006 to October 2012 (6,111 exams analyzed) in patients at our ophthalmic emergency department, with analysis of the different angiographic aspects of the MEWDS-diagnosed cases...
July 2015: Arquivos Brasileiros de Oftalmologia
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