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https://www.readbyqxmd.com/read/28539002/from-in-vivo-to-in-vitro-the-medical-device-testing-paradigm-shift
#1
Dayna Kerecman Myers, Alan M Goldberg, Albrecht Poth, Michael F Wolf, Joseph Carraway, James McKim, Kelly P Coleman, Richard Hutchinson, Ronald Brown, Harald F Krug, Anthony Bahinski, Thomas Hartung
Amid growing efforts to advance the replacement, reduction, and refinement of the use of animals in research, there is a growing recognition that in vitro testing of medical devices can be more effective, both in terms of cost and time, and also more reliable than in vivo testing. Although the technological landscape has evolved rapidly in support of these concepts, regulatory acceptance of alternative testing methods has not kept pace. Despite the acceptance by regulators of some in vitro tests (cytotoxicity, gene toxicity, and some hemocompatibility assays), many toxicity tests still rely on animals (irritation, sensitization, acute toxicity, reproductive/developmental toxicity), even where other industrial sectors have already abandoned them...
May 25, 2017: ALTEX
https://www.readbyqxmd.com/read/28538781/effects-that-passive-cycling-exercise-have-on-muscle-strength-duration-of-mechanical-ventilation-and-length-of-hospital-stay-in-critically-ill-patients-a-randomized-clinical-trial
#2
Aline Dos Santos Machado, Ruy Camargo Pires-Neto, Maurício Tatsch Ximenes Carvalho, Janice Cristina Soares, Dannuey Machado Cardoso, Isabella Martins de Albuquerque
Objective: To evaluate the effects that passive cycling exercise, in combination with conventional physical therapy, have on peripheral muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients admitted to the ICU of a tertiary care university hospital. Methods: This was a randomized clinical trial involving 38 patients (≥ 18 years of age) on mechanical ventilation who were randomly divided into two groups: control (n = 16), receiving conventional physical therapy; and intervention (n = 22), receiving conventional physical therapy and engaging in passive cycling exercise five days per week...
March 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28538603/a-systematic-review-of-the-exercise-effect-on-bone-health-the-importance-of-assessing-mechanical-loading-in-perimenopausal-and-postmenopausal-women
#3
Borja Sañudo, Moisés de Hoyo, Jesús Del Pozo-Cruz, Luis Carrasco, Borja Del Pozo-Cruz, Sergio Tejero, Elwyn Firth
OBJECTIVE: The aims of this systematic review were to determine the general effects of exercise on areal bone mineral density (BMD) in perimenopausal and postmenopausal women, and to provide information on the most suitable bone-loading exercise regimens that may improve bone health in this population group. METHODS: A computerized, systematic literature search was performed in the electronic databases PubMed, Web of Science, CINAHL, SPORTDiscus, and The Cochrane Library, from January 2005 to November 2015, to identify all randomized controlled trials related to exercise in perimenopausal and postmenopausal women...
May 22, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28538572/intratendinous-injection-of-hydrogel-for-reseeding-decellularized-human-flexor-tendons
#4
Chao Long, Michael G Galvez, Anais Legrand, Lydia-Marie Joubert, Zhen Wang, Arhana Chattopadhyay, James Chang, Paige M Fox
BACKGROUND: Decellularized cadaveric tendons are a potential source for reconstruction. Reseeding to enhance healing is ideal; however, cells placed on the tendon surface result in inadequate delivery. The authors used an injection technique to evaluate intratendinous cell delivery. METHODS: Decellularized tendons were reseeded with adipose-derived stem cells in culture, and injected with fetal bovine serum or hydrogel. PKH26-stained cells in cross-section were quantified...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538530/clinical-assessment-and-diagnostics-of-patients-with-hand-disorders-a-case-study-approach
#5
Mabel Qi He Leow, Rebecca Qian Ru Lim, Shian Chao Tay
Clinical assessment of the hand is important for diagnosing underlying hand disorders. Using a case study approach, the clinical assessment for three disorders of the hands is presented: trigger finger (stenosing tenosynovitis), carpal tunnel syndrome, and ulnar-sided wrist injury (styloid impingement). We assess the annular one pulley and finger range of motion for patients with trigger finger. To diagnose for carpal tunnel syndrome, assessment for Tinel's sign, Phalen's sign, abductor pollicis brevis muscle bulk, two-point discrimination, and obtaining a nerve conduction study are performed...
May 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28538382/improvement-of-fatigue-after-vitamin-d-supplementation-in-kidney-transplant-recipients
#6
Bin Han, Xiao Wu, Yong Guo
Low serum levels of vitamin D have been associated with fatigue in both healthy and clinical populations. Our aim was to evaluate the effect of vitamin D supplementation on fatigue in kidney transplant recipients (KTRs). In total, 137 patients after kidney transplant and 119 age- and sex-matched healthy volunteers were recruited. Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured by competitive protein-binding assay. Fatigue was assessed using the subscale fatigue of the Checklist Individual Strength (CIS)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538328/a-systematic-review-of-the-association-between-physical-fitness-and-musculoskeletal-injury-risk-part-1-cardiorespiratory-endurance
#7
Peter J Lisman, Sarah J de la Motte, Timothy C Gribbin, Dianna P Jaffin, Kaitlin Murphy, Patricia A Deuster
Lisman, PJ, de la Motte, SJ, Gribbin, TC, Jaffin, DP, Murphy, K, and Deuster, PA. A systematic review of the association between physical fitness and musculoskeletal injury risk: part 1-cardiorespiratory endurance. J Strength Cond Res 31(6): 1744-1757, 2017-Musculoskeletal injuries (MSK-Is) are a significant health problem for both military and athletic populations. Research indicates that MSK-I is associated with physical fitness; however, the association between specific components of physical fitness and MSK-I in military and athletic populations has not been systematically examined...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538327/quantifying-the-effect-of-carbohydrate-mouth-rinsing-on-exercise-performance
#8
Daniel J Peart
Peart, DJ. Quantifying the effect of carbohydrate mouth rinsing on exercise performance. J Strength Cond Res 31(6): 1737-1743, 2017-The purpose of this study was to review the existing literature investigating carbohydrate mouth rinsing as an ergogenic aid using the effect sizes (ES) and percentage change in performance of the respective studies as outcome measures. A trivial-small average overall ES was present for the 25 studies included in the review (0.18, 95% confidence interval [CI] = 0.10-0.27). Effect sizes for the subgroups were ≥25 minutes (0...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538326/technology-in-strength-and-conditioning-tracking-lower-limb-exercises-with-wearable-sensors
#9
Martin A OʼReilly, Darragh F Whelan, Tomas E Ward, Eamonn Delahunt, Brian Caulfield
O'Reilly, MA, Whelan, DF, Ward, TE, Delahunt, E, and Caulfield, B. Technology in strength and conditioning tracking lower-limb exercises with wearable sensors. J Strength Cond Res 31(6): 1726-1736, 2017-Strength and conditioning (S&C) coaches offer expert guidance to help those they work with achieve their personal fitness goals. However, because of cost and availability issues, individuals are often left training without expert supervision. Recent developments in inertial measurement units (IMUs) and mobile computing platforms have allowed for the possibility of unobtrusive motion tracking systems and the provision of real-time individualized feedback regarding exercise performance...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538325/heart-rate-variability-discriminates-competitive-levels-in-professional-soccer-players
#10
Riccardo Proietti, Selenia di Fronso, Lucas A Pereira, Laura Bortoli, Claudio Robazza, Fabio Y Nakamura, Maurizio Bertollo
Proietti, R, di Fronso, S, Pereira, LA, Bortoli, L, Robazza, C, Nakamura, FY, and Bertollo, M. Heart rate variability discriminates competitive levels in professional soccer players. J Strength Cond Res 31(6): 1719-1725, 2017-Heart rate variability (HRV) has been increasingly used to monitor team sports athletes. Besides the traditional time domain indices (i.e., the SD of successive RR intervals [SDNN] and the root mean square difference of successive normal RR intervals [RMSSD]), recently the use of the stress score (SS), which is an inverse function of the SD2 index derived from the Poincaré plot, and the sympathetic/parasympathetic ratio (S/PS) to monitor soccer players has been proposed...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538324/physical-fitness-reference-standards-in-french-youth-the-bouge-program
#11
Jérémy Vanhelst, Julien Labreuche, Laurent Béghin, Elodie Drumez, Paul S Fardy, Didier Chapelot, Jacques Mikulovic, Zékya Ulmer
Vanhelst, J, Julien, JL, Beghin, L, Drumez, E, Fardy, PS, Chapelot, D, Mikulovic, J, and Ulmer, Z. Physical fitness reference standards in French youth: The BOUGE program. J Strength Cond Res 31(6): 1709-1718, 2017-The aim of this study was to establish sex- and age-specific physical fitness percentiles in French youth. A sample of 11,186 children and adolescents (5,546 boys and 5,640 girls), aged between 10 and 15 years, was assessed in the French national BOUGE study. Participants were tested for their cardiorespiratory fitness, muscular endurance, speed, flexibility, and agility using the following tests: 20-m shuttle run tests, curl-ups test, 50-m sprint test, back-saver sit and reach test, and 10 × 5-m shuttle run test...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538323/the-effect-of-a-psychomotor-education-program-on-the-static-balance-of-children-with-intellectual-disability
#12
Eleni G Fotiadou, Konstantina H Neofotistou, Paraskevi F Giagazoglou, Vasilios K Tsimaras
Fotiadou, EG, Neofotistou, KH, Giagazoglou, PF, and Tsimaras, VK. The effect of a psychomotor education program on the static balance of children with intellectual disability. J Strength Cond Res 31(6): 1702-1708, 2017-Children with intellectual disability (ID) demonstrate lower balance ability which results in substantial delays in motor growth and limits their function level. Psychomotor education comprises a holistic movement approach, with the aim to improve all aspects of each child personality. The aim of this study was to assess the effect of a psychomotor education program on static balance of school-aged children with ID...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538322/manifestations-of-proprioception-during-vertical-jumps-to-specific-heights
#13
Artur Struzik, Bogdan Pietraszewski, Adam Kawczyński, Sławomir Winiarski, Grzegorz Juras, Andrzej Rokita
Artur, S, Bogdan, P, Kawczyński, A, Winiarski, S, Grzegorz, J, and Andrzej, R. Manifestations of proprioception during vertical jumps to specific heights. J Strength Cond Res 31(6): 1694-1701, 2017-Jumping and proprioception are important abilities in many sports. The efficiency of the proprioceptive system is indirectly related to jumps performed at specified heights. Therefore, this study recorded the ability of young athletes who play team sports to jump to a specific height compared with their maximum ability...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538321/muscle-activation-differs-between-partial-and-full-back-squat-exercise-with-external-load-equated
#14
Josinaldo J da Silva, Brad J Schoenfeld, Priscyla N Marchetti, Silvio L Pecoraro, Julia M D Greve, Paulo H Marchetti
da Silva, JJ, Schoenfeld, BJ, Marchetti, PN, Pecoraro, SL, Greve, JMD, and Marchetti, PH. Muscle activation differs between partial and full back squat exercise with external load equated. J Strength Cond Res 31(6): 1688-1693, 2017-Changes in range of motion affect the magnitude of the load during the squat exercise and, consequently, may influence muscle activation. The purpose of this study was to evaluate muscle activation between the partial and full back squat exercise with external load equated on a relative basis between conditions...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538320/the-effects-of-a-heel-wedge-on-hip-pelvis-and-trunk-biomechanics-during-squatting-in-resistance-trained-individuals
#15
Jesse M Charlton, Connor A Hammond, Christopher K Cochrane, Gillian L Hatfield, Michael A Hunt
Charlton, JM, Hammond, CA, Cochrane, CK, Hatfield, GL, and Hunt, MA. The effects of a heel wedge on hip, pelvis, and trunk biomechanics during squatting in resistance trained individuals. J Strength Cond Res 31(6): 1678-1687, 2017-Barbell back squats are a popular exercise for developing lower extremity strength and power. However, this exercise has potential injury risks, particularly to the lumbar spine, pelvis, and hip joint. Previous literature suggests heel wedges as a means of favorably adjusting trunk and pelvis kinematics with the intention of reducing such injury risks...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538319/reliability-and-accuracy-of-a-standardized-shallow-water-running-test-to-determine-cardiorespiratory-fitness
#16
Elizabeth F Nagle, Mary E Sanders, Bethany B Gibbs, Barry A Franklin, Jacquelyn A Nagle, Philip J Prins, Caleb D Johnson, Robert J Robertson
Nagle, EF, Sanders, ME, Gibbs, BB, Franklin, BA, Nagle, JA, Prins, PJ, Johnson, CD, and Robertson, RJ. Reliability and accuracy of a standardized shallow water running test to determine cardiorespiratory fitness. J Strength Cond Res 31(6): 1669-1677, 2017-A standardized fitness assessment is critical for the development of an individualized exercise prescription. Although the benefits of aquatic exercise have been well established, there remains the need for a standardized nonswimming protocol to accurately assess cardiorespiratory fitness (CRF) in shallow water...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538318/do-fencers-require-a-weapon-specific-approach-to-strength-and-conditioning-training
#17
Anthony N Turner, Chris J Bishop, Jon A Cree, Michael L Edwards, Shyam Chavda, Paul J Read, David M J Kirby
Turner, AN, Bishop, CJ, Cree, JA, Edwards, ML, Chavda, S, Read, PJ, and Kirby, DMJ. Do fencers require a weapon-specific approach to strength and conditioning training? J Strength Cond Res 31(6): 1662-1668, 2017-There are 3 types of weapons used in Olympic fencing: the épée, foil, and sabre. The aim of this study was to determine if fencers exhibited different physical characteristics across weapons. Seventy-nine male (n = 46) and female (n = 33) national standard fencers took part in this study. Fencers from each weapon (male and female), i...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538317/effects-of-inertial-setting-on-power-force-work-and-eccentric-overload-during-flywheel-resistance-exercise-in-women-and-men
#18
Luis M Martinez-Aranda, Rodrigo Fernandez-Gonzalo
Martinez-Aranda, LM and Fernandez-Gonzalo, R. Effects of inertial setting on power, force, work and eccentric overload during flywheel resistance exercise in women and men. J Strength Cond Res 31(6): 1653-1661, 2017-Exercise load is a key component in determining end-point adaptations to resistance exercise. Yet, there is no information regarding the use of different inertia (i.e., loads) during isoinertial flywheel resistance exercise, a very popular high-intensity training model. Thus, this study examined power, work, force, and eccentric overload produced during flywheel resistance exercise with different inertial settings in men and women...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538316/load-absorption-force-time-characteristics-following-the-second-pull-of-weightlifting-derivatives
#19
Timothy J Suchomel, Jason P Lake, Paul Comfort
Suchomel, TJ, Lake, JP, and Comfort, P. Load absorption force-time characteristics following the second pull of weightlifting derivatives. J Strength Cond Res 31(6): 1644-1652, 2017-The purpose of this study was to compare the load absorption force-time characteristics of weightlifting catching and pulling derivatives. Twelve resistance-trained men performed repetitions of the hang power clean (HPC), jump shrug (JS), and hang high pull (HHP) on a force platform with 30, 45, 65, and 80% of their 1-repetition maximum HPC...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538315/evaluation-of-the-effectiveness-of-compression-garments-on-autonomic-nervous-system-recovery-after-exercise
#20
Alessandro Piras, Giorgio Gatta
Piras, A and Gatta, G. Evaluation of the effectiveness of compression garments on autonomic nervous system recovery after exercise. J Strength Cond Res 31(6): 1636-1643, 2017-The aim of this investigation was to evaluate the recovery pattern of a whole-body compression garment on hemodynamic parameters and on autonomic nervous system (ANS) activity after a swimming performance. Ten young male athletes were recruited and tested in 2 different days, with and without wearing the garment during the recovery phase...
June 2017: Journal of Strength and Conditioning Research
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