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https://www.readbyqxmd.com/read/28803772/perioperative-statins-do-not-prevent-acute-kidney-injury-after-cardiac-surgery-a-meta-analysis-of-randomized-controlled-trials
#1
Bing-Cheng Zhao, Pu Shen, Ke-Xuan Liu
OBJECTIVES: To evaluate whether perioperative statins reduce the risk of acute kidney injury (AKI) after cardiac surgery. DESIGN: Systematic review and meta-analysis of randomized trials. SETTING: Perioperative management in hospitals that perform cardiac surgery. PARTICIPANTS: Adult patients undergoing cardiac surgery. INTERVENTIONS: PubMed, EMBASE, and the Cochrane Library databases were searched for randomized trials...
April 21, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28799819/no-cardiovascular-benefit-with-evacetrapib-is-this-the-end-of-the-road-for-the-cetrapibs
#2
Sheila A Doggrell
Introduction Increasing high-density lipoprotein(HDL) cholesterol levels predict improved cardiovascular outcomes. However, inhibiting cholesteryl ester transfer protein (CETP) to increase HDL cholesterol, with the 'cetrapibs' (torcetrapib and dalcetrapib), did not improve cardiovascular clinical outcomes. Despite these findings, the clinical outcomes trial with evacetrapib continued. Areas covered Treatment with evacetrapib increased the levels of HDL by ~130%, and decreased low-density lipoprotein (LDL) cholesterol by ~37%...
August 11, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28797470/balancing-primary-prevention-and-statin-induced-diabetes-mellitus-prevention
#3
REVIEW
Yogita Rochlani, Ajoe John Kattoor, Naga Venkata Pothineni, Raga Deepak Reddy Palagiri, Francesco Romeo, Jawahar L Mehta
Diabetes mellitus (DM), a modern-day epidemic, is a significant risk factor for cardiovascular disease. It is believed that statins elevate the risk of incident DM. Multiple trials were suggestive of the hyperglycemic effect of long-term statin use. This has prompted the Food and Drug Administration to include the risk of DM in the product label of statins. New-onset DM with statin use is biologically plausible and can be explained based on the multiple pathways in glucose metabolism affected by statins. Most pivotal clinical trials on statins were not powered to adequately assess the risk of incident DM with statin use, and the results from multiple meta-analyses are mixed...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28790154/ckm-glu83gly-is-associated-with-blunted-creatine-kinase-variation-but-not-with-myalgia
#4
Moneeza Kalhan Siddiqui, Abirami Veluchamy, Cyrielle Maroteau, Roger Tavendale, Fiona Carr, Ewan Pearson, Helen Colhoun, Andrew D Morris, Jacob George, Alexander Doney, Munir Pirmohamed, Ana Alfirevic, Mia Wadelius, Anke H Maitland van der Zee, Paul M Ridker, Daniel I Chasman, Colin N A Palmer
BACKGROUND: To test the association of a recently reported variant in the creatine kinase (CK) muscle gene, CKM Glu83Gly (rs11559024) with constitutive creatine phosphokinase (CK) levels, CK variation, and inducibility. Given the diagnostic importance of CK in determining muscle damage, we tested the association of the variant with myalgia. METHODS AND RESULTS: Meta-analysis between longitudinal cohort GoDARTS (Genetics of Diabetes Audit and Research, Tayside Scotland), minor allele frequency (=0...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28779871/meta-analysis-of-placebo-controlled-randomized-controlled-trials-on-the-prevalence-of-statin-intolerance
#5
REVIEW
Haris Riaz, Abdur Rahman Khan, Muhammad Shahzeb Khan, Karim Abdur Rehman, Shehab Ahmad Redha Alansari, Bashaer Gheyath, Sajjad Raza, Amr Barakat, Faraz Khan Luni, Haitham Ahmed, Richard A Krasuski
The prevalence of intolerance varies widely. Stopping statin therapy is associated with worse outcomes in patients with cardiovascular disease. Despite extensive studies, the benefits and risks of statins continue to be debated by clinicians and the lay public. We searched the PubMed, Medline, and Cochrane Central Register of Controlled Trials (CENTRAL) databases for all randomized controlled trials of statins compared with placebo. Studies were included if they had ≥1,000 participants, had patients who were followed up for ≥1 year, and reported rates of drug discontinuation...
June 13, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28777739/statins-and-the-risk-of-cirrhosis-in-hepatitis-b-or-c-patients-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#6
Yaqin Wang, Jianping Xiong, Meng Niu, Xiaowei Chen, Long Gao, Qirun Wu, Kechuang Zheng, Ke Xu
Hepatitis B and hepatitis C are leading causes of chronic liver disease, particularly cirrhosis. Recently, several studies have observed that statins have an inverse relationship with cirrhosis in hepatitis B or C patients. However, no published meta-analysis studied the protective effect of statins on cirrhosis. Thus, we conducted a systematic review and meta-analysis of published observational studies to better understand the relationship between statins and the risk of cirrhosis. Relevant studies were identified by searching PubMed, EMBASE, and ISI Web of Science for articles published before April 2017...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28768753/pcsk9-loss-of-function-variants-low-density-lipoprotein-cholesterol-and-risk-of-coronary-heart-disease-and-stroke-data-from-9-studies-of-blacks-and-whites
#7
Shia T Kent, Robert S Rosenson, Christy L Avery, Yii-Der I Chen, Adolfo Correa, Steven R Cummings, L Adrienne Cupples, Mary Cushman, Daniel S Evans, Vilmundur Gudnason, Tamara B Harris, George Howard, Marguerite R Irvin, Suzanne E Judd, J Wouter Jukema, Leslie Lange, Emily B Levitan, Xiaohui Li, Yongmei Liu, Wendy S Post, Iris Postmus, Bruce M Psaty, Jerome I Rotter, Monika M Safford, Colleen M Sitlani, Albert V Smith, James D Stewart, Stella Trompet, Fangui Sun, Ramachandran S Vasan, J Michael Woolley, Eric A Whitsel, Kerri L Wiggins, James G Wilson, Paul Muntner
BACKGROUND: PCSK9 loss-of-function (LOF) variants allow for the examination of the effects of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We examined the association of PCSK9 LOF variants with LDL-C and incident coronary heart disease and stroke through a meta-analysis of data from 8 observational cohorts and 1 randomized trial of statin therapy. METHODS AND RESULTS: These 9 studies together included 17 459 blacks with 403 (2...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28762053/erratum-to-dose-related-effect-of-statins-in-patients-with-endovascular-coiling-or-microsurgical-clipping-for-aneurysmal-subarachnoid-hemorrhage-updated-study-level-meta-analysis
#8
Kyu-Sun Choi, Jae Min Kim, Hyeong-Joong Yi, Seon-Heui Lee, Taeho Lim, Wonhee Kim, Youngsuk Cho, Jin-Hwan Cheong
No abstract text is available yet for this article.
September 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28749884/original-research-the-effects-of-red-yeast-rice-supplementation-on-cholesterol-levels-in-adults
#9
REVIEW
Diane Peng, Amy Fong, Amanda van Pelt
: Purpose: Red yeast rice (RYR) supplementation has become a popular alternative to statin therapy in treating hypercholesterolemia. This state-of-the-science review seeks to explore the most recent evidence on the effectiveness and safety of RYR supplementation in treating dyslipidemic adults. METHODS: This review extends the time frame of a meta-analysis performed by Li and colleagues in 2014; specifically, we looked at the literature published between September 2013 and April 2016...
August 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28741244/efficacy-and-safety-of-alternate-day-versus-daily-dosing-of-statins-a-systematic-review-and-meta-analysis
#10
REVIEW
Kamal Awad, Dimitri P Mikhailidis, Peter P Toth, Steven R Jones, Patrick Moriarty, Gregory Y H Lip, Paul Muntner, Alberico L Catapano, Michael J Pencina, Robert S Rosenson, Jacek Rysz, Maciej Banach
PURPOSE: We conducted a meta-analysis of randomized controlled trials (RCTs) and quasi-RCTs to synthesize evidence about the efficacy and safety of alternate-day vs daily dosing of statins. METHODS: We searched selected databases through January 2, 2017 to identify relevant RCTs and quasi-RCTs. The primary outcome was change in low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG), while secondary outcomes included adverse events and adherence...
July 24, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28720842/pre-diagnostic-statin-use-lymph-node-status-and-mortality-in-women-with-stages-i-iii-breast-cancer
#11
Amelia Smith, Laura Murphy, Lina Zgaga, Thomas I Barron, Kathleen Bennett
BACKGROUND: Recent meta-analyses suggest that pre-diagnostic statin use is associated with reduced breast cancer-specific mortality. Studies have shown that high breast tumour expression of the statin target (3-hydroxy-3-methylglutaryl coenzyme-A reductase) is associated with lymph-node negative cancer. Therefore, we examined the association between pre-diagnostic statin use and; lymph node status, breast cancer-specific and all-cause mortality. METHODS: Women with stages I-III breast cancer were identified from the National Cancer Registry of Ireland (N=6314)...
August 8, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28711915/statin-use-and-endometrial-cancer-risk-a-meta-analysis
#12
Weimin Xie, Qiaoling Zhu, Qiao Liu, Yingxia Wang, Jing Yang, Lili Hu
Several studies have evaluated the association between statin use and endometrial cancer risk. We carried out a meta-analysis of randomized controlled trials (RCTs) and non-randomized studies to evaluate the effect of statins on endometrial cancer risk. A comprehensive search of electronic databases, conference abstracts and clinical trial registers was conducted for published and unpublished results. Studies that evaluated exposure to statins and endometrial cancer risk were considered. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using either a fixed-effects or a random-effects model...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699974/cardiovascular-risk-stratification-and-statin-eligibility-based-on-the-brazilian-vs-north-american-guidelines-on-blood-cholesterol-management
#13
Fernando Henpin Yue Cesena, Antonio Gabriele Laurinavicius, Viviane A Valente, Raquel D Conceição, Raul D Santos, Marcio S Bittencourt
Background: The best way to select individuals for lipid-lowering treatment in the population is controversial. Objective: In healthy individuals in primary prevention: to assess the relationship between cardiovascular risk categorized according to the V Brazilian Guideline on Dyslipidemia and the risk calculated by the pooled cohort equations (PCE); to compare the proportion of individuals eligible for statins, according to different criteria. Methods: In individuals aged 40-75 years consecutively submitted to routine health assessment at one single center, four criteria of eligibility for statin were defined: BR-1, BR-2 (LDL-c above or at least 30 mg/dL above the goal recommended by the Brazilian Guideline, respectively), USA-1 and USA-2 (10-year risk estimated by the PCE ≥ 5...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28695455/pcsk9-inhibitors-for-treating-dyslipidemia-in-patients-at-different-cardiovascular-risk-a-systematic-review-and-a-meta-analysis
#14
Alessandro Squizzato, Matteo Basilio Suter, Marta Nerone, Robert Patrick Giugliano, Francesco Dentali, Andrea Maria Maresca, Leonardo Campiotti, Anna Maria Grandi, Luigina Guasti
Statin-induced lowering of low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular morbidity and mortality, but many patients do not adequately reduce their LDL-C levels. Monoclonal antibodies targeting PCKS9 are currently in the advanced phase of development. We aimed to investigate the efficacy and safety of PCSK9 inhibitors in patients at different cardiovascular risk in a systematic review. Studies were searched on MEDLINE and EMBASE until January 2016. Differences in the outcomes among groups were expressed as mean differences, or pooled odds ratio (OR) and corresponding 95% confidence interval (CI), which were calculated using a fixed-effects and a random-effects model...
July 10, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28691139/systematic-review-and-meta-analysis-use-of-statins-is-associated-with-a-reduced-incidence-of-oesophageal-adenocarcinoma
#15
Tom Thomas, Yoon Loke, Ian L P Beales
PURPOSE: Laboratory studies have suggested that statins may have useful anti-cancer effects against Barrett's epithelial cancer lines. A variety of effects have been reported in clinical studies. METHODS: We performed a systematic review and meta-analysis of the association between statin use and the development of oesophageal cancer. Multiple databases were searched for studies reporting the association of statin use and oesophageal cancer. Meta-analysis on the relationship between statin use and cancer incidence was performed...
July 10, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28682909/statins-intake-and-risk-of-liver-cancer-a-dose-response-meta-analysis-of-prospective-cohort-studies
#16
Changhong Yi, Zhenggui Song, Maolin Wan, Ya Chen, Xiang Cheng
Previous studies have indicated that statins intake was associated with liver cancer risk, but presented controversial results.Studies in PubMed and EMBASE were searched update to February 2017 to identify and quantify the potential dose-response association between statins intake and liver cancer.Six eligible studies involving a total of 11,8961 participants with 9530 incident cases were included in this meta-analysis. Statistically significant association was observed between increasing statins intake and liver cancer risk reduction (OR = 0...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28682890/efficacy-of-short-term-moderate-or-high-dose-rosuvastatin-in-preventing-contrast-induced-nephropathy-a-meta-analysis-of-15-randomized-controlled-trials
#17
REVIEW
Min Liang, Shicheng Yang, Naikuan Fu
BACKGROUND: The prophylactic efficacy of statin pretreatment for the prevention of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI) remains controversial. The aim of the study was to perform a meta-analysis of randomized controlled trials (RCTs) to assess the effectiveness of short-term moderate or high-dose rosuvastatin pretreatment in preventing CIN. METHODS: We included RCTs comparing short-term moderate or high-dose rosuvastatin treatment versus low-dose rosuvastatin treatment or placebo for preventing CIN...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28647412/real-world-data-to-assess-changes-in-low-density-lipoprotein-cholesterol-and-predicted-cardiovascular-risk-after-ezetimibe-discontinuation-post-reporting-of-the-ezetimibe-and-simvastatin-in-hypercholesterolemia-enhances-atherosclerosis-regression-trial
#18
Harold E Bays, Mehul D Patel, Panagiotis Mavros, Dena R Ramey, Joanne E Tomassini, Andrew M Tershakovec, Carl A Baxter
BACKGROUND: The 2008 Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) study demonstrated ezetimibe + simvastatin vs simvastatin alone had a neutral effect on the surrogate endpoint of carotid intima-media thickness. Subsequent media portrayal of the study prompted ezetimibe discontinuation in many patients. OBJECTIVE: The objective of the study was to assess the impact of ENHANCE reporting on ezetimibe discontinuation, low-density lipoprotein cholesterol (LDL-C) changes, and potential cardiovascular disease (CVD) risk...
May 8, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28629445/effects-of-perioperative-statin-use-on-cardiovascular-complications-in-patients-submitted-to-non-cardiac-surgery-protocol-for-a-systematic-review-meta-analysis-and-trial-sequential-analysis
#19
Erica Aranha Suzumura, Rodrigo Antonini Ribeiro, Leticia Kawano-Dourado, Pedro Gabriel de Barros E Silva, Claudia Oliveira, Mabel Fernandes Figueiró, Alexandre Biasi Cavalcanti, Renato D Lopes, Otavio Berwanger
BACKGROUND: Preliminary evidence suggests statins may reduce major perioperative vascular events. However, evidence is limited to observational studies, underpowered trials, and non-comprehensive systematic reviews. This review aims to assess the effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery. METHODS: We will search MEDLINE/PubMed, EMBASE, LILACS, CENTRAL, Web of Science, and CINAHL for randomized controlled trials assessing the effects of perioperative statin use in adults undergoing non-cardiac surgery and reporting cardiovascular complications...
June 19, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28616955/niacin-for-primary-and-secondary-prevention-of-cardiovascular-events
#20
REVIEW
Stefan Schandelmaier, Matthias Briel, Ramon Saccilotto, Kelechi K Olu, Armon Arpagaus, Lars G Hemkens, Alain J Nordmann
BACKGROUND: Nicotinic acid (niacin) is known to decrease LDL-cholesterol, and triglycerides, and increase HDL-cholesterol levels. The evidence of benefits with niacin monotherapy or add-on to statin-based therapy is controversial. OBJECTIVES: To assess the effectiveness of niacin therapy versus placebo, administered as monotherapy or add-on to statin-based therapy in people with or at risk of cardiovascular disease (CVD) in terms of mortality, CVD events, and side effects...
June 14, 2017: Cochrane Database of Systematic Reviews
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