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https://www.readbyqxmd.com/read/29165956/prophylactic-management-of-contrast-induced-acute-kidney-injury-in-high-risk-patients
#1
Diya Nahar
Contrast-induced acute kidney injury (CI-AKI) has been linked to morbidity and mortality, especially in high-risk patients whose kidney function is compromised. Recently, many studies have been conducted to search for more novel, preventative methods of decreasing CI-AKI. Through a detailed analysis of recent studies, this article discusses recommendations for hydration, N-acetylcysteine, and statin therapy in relation to the prophylactic management of CI-AKI in high-risk patients.
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29154680/cardiovascular-disease-predictors-and-adipose-tissue-macrophage-polarization-is-there-a-link
#2
Ivana Kralova Lesna, Marek Petras, Sona Cejkova, Anna Kralova, Jiri Fronek, Libor Janousek, Filip Thieme, Tomas Tyll, Rudolf Poledne
Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous and visceral adipose tissues were obtained from 79 subjects, 52 living kidney donors (during nephrectomy) and 27 patients with peripheral artery disease (during arterial tree reconstruction). Methods Macrophage subsets were isolated from adipose tissues and analysed by flow cytometry using CD14, CD16, CD36 and CD163 monoclonal antibodies...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29146277/lowering-ldl-cholesterol-reduces-cardiovascular-risk-independently-of-presence-of-inflammation
#3
Benjamin C Storey, Natalie Staplin, Richard Haynes, Christina Reith, Jonathan Emberson, William G Herrington, David C Wheeler, Robert Walker, Bengt Fellström, Christoph Wanner, Martin J Landray, Colin Baigent
Markers of inflammation, including plasma C-reactive protein (CRP), are associated with an increased risk of cardiovascular disease, and it has been suggested that this association is causal. However, the relationship between inflammation and cardiovascular disease has not been extensively studied in patients with chronic kidney disease. To evaluate this, we used data from the Study of Heart and Renal Protection (SHARP) to assess associations between circulating CRP and LDL cholesterol levels and the risk of vascular and non-vascular outcomes...
November 14, 2017: Kidney International
https://www.readbyqxmd.com/read/29145723/statin-initiation-and-renal-outcomes-following-isolated-coronary-artery-bypass-grafting-a-meta-analysis
#4
Yushu Wang, Sui Zhu, Rongsheng DU, Juteng Zhou, Yucheng Chen, Qing Zhang
BACKGROUND: The effects of preoperative statin therapy (PST) on renal outcomes in patients with isolated coronary artery bypass grafting (CABG) are in controversial. This study aimed to assess the effects of preoperative statin use on postoperative renal outcomes in patients undergoing isolated CABG. METHODS: PubMed, EMBASE, and Cochrane Library were searched for studies published up to February 2017. Pooled odds ratio (OR) and its corresponding 95% confidence interval (95% CI) were calculated...
November 16, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29137111/effect-of-omega-3-fatty-acid-supplementation-on-plasma-fibroblast-growth-factor-23-levels-in-post-myocardial-infarction-patients-with-chronic-kidney-disease-the-alpha-omega-trial
#5
Martin H de Borst, Leandro C Baia, Ellen K Hoogeveen, Erik J Giltay, Gerjan Navis, Stephan J L Bakker, Johanna M Geleijnse, Daan Kromhout, Sabita S Soedamah-Muthu
Fibroblast growth factor 23 (FGF23) is an independent risk factor for cardiovascular mortality in chronic kidney disease. Omega-3 (n-3) fatty acid consumption has been inversely associated with FGF23 levels and with cardiovascular risk. We examined the effect of marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and plant-derived alpha-linolenic acid (ALA) on plasma FGF23 levels in post-myocardial infarction patients with chronic kidney disease. In the randomized double-blind Alpha Omega Trial, 4837 patients with a history of myocardial infarction aged 60-80 years (81% men) were randomized to one of four trial margarines supplemented with a targeted additional intake of 400 mg/day EPA and DHA, 2 g/day ALA, EPA-DHA plus ALA, or placebo for 41 months...
November 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29128438/renin-angiotensin-system-blockers-and-statins-are-associated-with-lower-in-hospital-mortality-in-very-elderly-hypertensives
#6
Francesco Spannella, Federico Giulietti, Paolo Balietti, Guido Cocci, Laura Landi, Francesca Elena Lombardi, Elisabetta Borioni, Beatrice Bernardi, Giulia Rosettani, Valentina Bordoni, Riccardo Sarzani
OBJECTIVES: Cardiovascular diseases are mainly related to hypertension and dyslipidemia and increase with aging because of the larger time span for these risk factors to damage arterial blood vessels. The impact of cardiovascular drug therapy on outcomes in the very elderly hospitalized is still not well established. The aim of our study was to evaluate the associations between cardiovascular therapy and in-hospital mortality in very elderly hypertensives. DESIGN: Prospective observational study...
November 8, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29110930/determinants-of-acute-kidney-injury-and-renal-function-decline-after-endovascular-abdominal-aortic-aneurysm-repair
#7
Randolph G Statius van Eps, Banne Nemeth, Ronne T A Mairuhu, Jan J Wever, Hugo T C Veger, Hans van Overhagen, Lukas C van Dijk, Bob Knippenberg
OBJECTIVE/BACKGROUND: Endovascular aneurysm repair (EVAR) may be associated with renal injury and more insight is needed into potential risk factors. The aim was to identify clinical, anatomical, and peri-procedural parameters as potential risk factors for the occurrence of acute kidney injury (AKI) and to evaluate chronic kidney disease (CKD) after EVAR. METHODS: A cohort of 212 consecutive patients who underwent elective EVAR for abdominal aortic aneurysm from January 2009 to October 2016 was included...
October 27, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29110161/association-between-small-intestinal-bacterial-overgrowth-by-glucose-breath-test-and-coronary-artery-disease
#8
Andre Fialho, Andrea Fialho, Gursimran Kochhar, Aldo L Schenone, Prashanti Thota, Arthur J McCullough, Bo Shen
BACKGROUND: A possible role of gut bacteria and their metabolic by-products in the development of coronary artery disease (CAD) is suspected. There is a lack of studies evaluating the association of small intestinal bacterial overgrowth (SIBO) with the development of CAD. AIM: To evaluate the frequency and risk factors for angiography-confirmed CAD in patients with or without SIBO. METHODS: A total of 1059 patients tested for SIBO using the glucose hydrogen/methane breath test from 2006 to 2014 were evaluated...
November 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29107984/treatment-with-proteasome-inhibitor-bortezomib-decreases-organic-anion-transporting-polypeptide-oatp-1b3-mediated-transport-in-a-substrate-dependent-manner
#9
Khondoker Alam, Taleah Farasyn, Alexandra Crowe, Kai Ding, Wei Yue
OATP1B1 and OATP1B3 mediate hepatic uptake of many drugs (e.g., statins) and can mediate transporter-mediated drug-drug-interactions (DDIs). Bortezomib is the first-in-class proteasome inhibitor drug approved by the U. S. Food and Drug Administration for the treatment of multiple myeloma. The potential of bortezomib to cause OATP-mediated DDIs has not been assessed. The current study investigated the involvement of the ubiquitin-proteasome system (UPS) in OATP1B1 and OATP1B3 degradation and determined the effects of proteasome inhibitors on OATP1B1- and OATP1B3-mediated transport...
2017: PloS One
https://www.readbyqxmd.com/read/29104841/a-unique-case-of-drug-interaction-between-ticagrelor-and-statin-leading-to-acute-renal-failure
#10
Gbeminiyi Samuel, Adebayo C Atanda, Alex Onyemeh, Ahmad Awan, Oyintayo Ajiboye
Dual antiplatelet agents and high-intensity statins are frequently used in combination after myocardial infarction. Ticagrelor has the potential of causing acute kidney injury. Rosuvastatin is excreted through the kidneys and dose adjustment is needed in patients with kidney disease. When used in combination, they can potentiate the toxic effects of each other. We report a case of drug interaction between rosuvastatin and ticagrelor resulting in rhabdomyolysis and acute renal failure necessitating dialysis...
August 31, 2017: Curēus
https://www.readbyqxmd.com/read/29092845/clinical-predictors-for-lack-of-favorable-vascular-response-to-statin-therapy-in-patients-with-coronary-artery-disease-a-serial-optical-coherence-tomography-study
#11
Yoshiyasu Minami, Zhao Wang, Aaron D Aguirre, Daniel S Ong, Chong-Jin Kim, Shiro Uemura, Tsunenari Soeda, Hang Lee, James Fujimoto, Ik-Kyung Jang
BACKGROUND: Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. METHODS AND RESULTS: A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6...
November 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29090028/evaluation-of-the-effect-of-statins-on-post-surgical-patients-with-acute-kidney-injury
#12
Abkhiz Saeed, Valizade Hasanloei Mohammad Amin, Mahoori Alireza, Hooshiar Hadi, Alizadeh Osalou Rahimeh
INTRODUCTION: Acute kidney injury is the sudden and almost complete loss of renal function with reduced glomerular filtration rate, and it occurs whenever the kidneys are unable to excrete metabolic waste products. METHOD: This randomized double-blinded clinical trial was performed in an intensive care unit (ICU) of a university educational hospital. After randomization with a random assigning table of numbers, patients were divided into two groups: an intervention group and a control group...
June 2017: Mædica
https://www.readbyqxmd.com/read/29081218/effects-of-aspirin-nonsteroidal-anti-inflammatory-drugs-statin-and-cox2-inhibitor-on-the-developments-of-urological-malignancies-a-population-based-study-with-10-year-follow-up-data-in-korea
#13
Minyong Kang, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Chang Wook Jeong
Purpose: The purpose of this study was to determine the impact of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), statin and cyclooxygenase 2 (COX-2) inhibitor on the development of kidney, prostate and urothelial cancers by analyzing the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) database. Materials and Methods: Among a representative sample cohort of 1,025,340 participants in NHIS-NSC database in 2002, we extracted data of 799,850 individuals who visited the hospital more than once, and finally included 321,122 individuals aged 40 and older...
October 27, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29067238/lipid-disorders-in-patients-with-renal-failure-role-in-cardiovascular-events-and-progression-of-chronic-kidney-disease
#14
REVIEW
Luca Visconti, Salvatore Benvenga, Antonio Lacquaniti, Valeria Cernaro, Annamaria Bruzzese, Giovanni Conti, Michele Buemi, Domenico Santoro
The spectrum of lipid disorders in chronic kidney disease (CKD) is usually characterized by high triglycerides and reduced high dense lipoprotein (HDL), associated with normal or slightly reduced low dense lipoprotein (LDL)-cholesterol. This dyslipidemia is associated with an increased risk for atherosclerotic cardiovascular disease. Keys for the cardiovascular risk reduction in these patients are lowering the number and modifying the composition of the cholesterol-carrying atherogenic lipoprotein particles...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29045728/how-do-primary-care-doctors-in-england-and-wales-code-and-manage-people-with-chronic-kidney-disease-results-from-the-national-chronic-kidney-disease-audit
#15
Lois G Kim, Faye Cleary, David C Wheeler, Ben Caplin, Dorothea Nitsch, Sally A Hull
Background: In the UK, primary care records are electronic and require doctors to ascribe disease codes to direct care plans and facilitate safe prescribing. We investigated factors associated with coding of chronic kidney disease (CKD) in patients with reduced kidney function and the impact this has on patient management. Methods: We identified patients meeting biochemical criteria for CKD (two estimated glomerular filtration rates <60 mL/min/1.73 m2 taken >90 days apart) from 1039 general practitioner (GP) practices in a UK audit...
October 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29040268/benefit-and-harm-of-intensive-blood-pressure-treatment-derivation-and-validation-of-risk-models-using-data-from-the-sprint-and-accord-trials
#16
Sanjay Basu, Jeremy B Sussman, Joseph Rigdon, Lauren Steimle, Brian T Denton, Rodney A Hayward
BACKGROUND: Intensive blood pressure (BP) treatment can avert cardiovascular disease (CVD) events but can cause some serious adverse events. We sought to develop and validate risk models for predicting absolute risk difference (increased risk or decreased risk) for CVD events and serious adverse events from intensive BP therapy. A secondary aim was to test if the statistical method of elastic net regularization would improve the estimation of risk models for predicting absolute risk difference, as compared to a traditional backwards variable selection approach...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29038386/effect-of-statins-on-patients-and-graft-survival-in-kidney-transplant-recipients-a-survival-meta-analysis
#17
Zohre Rostami, Mahdi Moteshaker Arani, Mahmood Salesi, Mahdi Safiabadi, Behzad Einollahi
INTRODUCTION: Modifying cardiovascular risk factors is very important for the patients after kidney transplantation. Statins are a potentially beneficial intervention for kidney transplant patients, and the effect of statins on cardiovascular outcomes in patients with chronic kidney disease varies according to the stages. This systematic review summarizes the potential beneficial effects of statins on kidney allograft outcome. MATERIALS AND METHODS: A systematic review and meta-analysis was conducted by literature search using the PubMed, Science Direct, Scopus, ISI Web of Knowledge, and Google Scholar...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29028484/cholesterol-target-value-attainment-and-lipid-lowering-therapy-in-patients-with-stable-or-acute-coronary-heart-disease-results-from-the-dyslipidemia-international-study-ii
#18
Anselm K Gitt, Dominik Lautsch, Jean Ferrières, Gaetano M De Ferrari, Ami Vyas, Carl A Baxter, Lori D Bash, Veronica Ashton, Martin Horack, Wael Almahmeed, Fu-Tien Chiang, Kian Keong Poh, Philippe Brudi, Baishali Ambegaonkar
BACKGROUND AND AIMS: Low-density lipoprotein cholesterol (LDL-C) is a major contributor to cardiovascular disease. In the Dyslipidemia International Study II (DYSIS II), we determined LDL-C target value attainment, use of lipid-lowering therapy (LLT), and cardiovascular outcomes in patients with stable coronary heart disease (CHD) and those suffering from an acute coronary syndrome (ACS). METHODS: DYSIS II included patients from 18 countries. Patients with either stable CHD or an ACS were enrolled if they were ≥18 years old and had a full lipid profile available...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29027826/dietary-advanced-glycated-end-products-and-medicines-influence-the-expression-of-sirt1-and-ddost-in-peripheral-mononuclear-cells-from-long-term-type-1-diabetes-patients
#19
Daniele P Santos-Bezerra, Adriana Machado-Lima, Maria Beatriz Monteiro, Sharon N Admoni, Ricardo V Perez, Cleide G Machado, Maria Heloíza Shimizu, Ana M Cavaleiro, Karina Thieme, Márcia S Queiroz, Ubiratan F Machado, Daniel Giannella-Neto, Marisa Passarelli, Maria Lúcia Corrêa-Giannella
Quantitative polymerase chain reaction was employed to quantify expression of two genes coding for advanced glycation end-product receptors [RAGE ( AGER) and AGER1 ( DDOST)] and of the gene coding the deacetylase SIRT1 ( SIRT1) in peripheral blood mononuclear cells from type 1 diabetes patients without [Group A, n = 35; 28.5 (24-39) years old; median (interquartile interval)] or with at least one microvascular complication [Group B, n = 117; 34.5 (30-42) years old]; 31 healthy controls were also included. In a subgroup of 48 patients, daily advanced glycation end-products intake before blood collection was assessed...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29019063/statin-prescribing-in-the-elderly-special-considerations
#20
REVIEW
M Leya, N J Stone
PURPOSE OF REVIEW: Our aim was to examine the current evidence behind prescribing statins to individuals over 65 years of age with emphasis on those older than 75. Individuals over 75 years of age may often have multiple comorbidities and take many medications. Additionally, they are often underrepresented in randomized controlled trials (RCTs) of statins in older populations. While results of RCTs demonstrate the benefit of statin therapy in both primary and secondary prevention patients, clinicians must more carefully consider adverse effects and drug-drug interactions before prescribing statin therapy as well as determining the intensity in older individuals...
October 11, 2017: Current Atherosclerosis Reports
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