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https://www.readbyqxmd.com/read/29334570/the-effect-of-prehospital-transport-time-injury-severity-and-blood-transfusion-on-survival-of-us-military-casualties-in-iraq
#1
Russ S Kotwal, Laura L F Scott, Jud C Janak, Bruce W Tarpey, Jeffrey T Howard, Edward L Mazuchowski, Frank K Butler, Stacy A Shackelford, Jennifer M Gurney, Zsolt T Stockinger
BACKGROUND: Reducing time from injury to care can optimize trauma patient outcomes. A previous study of prehospital transport of US military casualties during the Afghanistan conflict demonstrated the importance of time and treatment capability for combat casualty survival. METHODS: A retrospective descriptive analysis was conducted to analyze battlefield data collected on US military combat casualties during the Iraq conflict from March 19, 2003 to August 31, 2010...
January 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29331490/supervised-machine-learning-for-population-genetics-a-new-paradigm
#2
REVIEW
Daniel R Schrider, Andrew D Kern
As population genomic datasets grow in size, researchers are faced with the daunting task of making sense of a flood of information. To keep pace with this explosion of data, computational methodologies for population genetic inference are rapidly being developed to best utilize genomic sequence data. In this review we discuss a new paradigm that has emerged in computational population genomics: that of supervised machine learning (ML). We review the fundamentals of ML, discuss recent applications of supervised ML to population genetics that outperform competing methods, and describe promising future directions in this area...
January 10, 2018: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29330510/shaping-and-controlled-fragmentation-of-liquid-metal-droplets-through-cavitation
#3
M S Krivokorytov, Q Zeng, B V Lakatosh, A Yu Vinokhodov, Yu V Sidelnikov, V O Kompanets, V M Krivtsun, K N Koshelev, C D Ohl, V V Medvedev
Targeting micrometer sized metal droplets with near-infrared sub-picosecond laser pulses generates intense stress-confined acoustic waves within the droplet. Spherical focusing amplifies their pressures. The rarefaction wave nucleates cavitation at the center of the droplet, which explosively expands with a repeatable fragmentation scenario resulting into high-speed jetting. We predict the number of jets as a function of the laser energy by coupling the cavitation bubble dynamics with Rayleigh-Taylor instabilities...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328798/the-early-days-of-surgery-for-cardiac-injuries
#4
Harold Ellis
Over many centuries, wounds of the heart were thought to be fatal. With the introduction of first anaesthesia and then antiseptic surgery in the second half of the 19th century, there was an explosion in surgery; the abdominal cavity, the chest, the skull were explored and operated upon and yet the heart was considered to be a 'no go' region of the body. One of the greatest and most innovative surgeons of that time, Theodor Billroth of Vienna, who must be considered one of the fathers of modern surgery, with pioneering work on many parts of the body, wrote: 'The surgeon who attempts to suture a wound of the heart should lose the respect of his colleagues'...
November 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29328702/peeling-off-neutron-skins-from-neutron-rich-nuclei-constraints-on-the-symmetry-energy-from-neutron-removal-cross-sections
#5
T Aumann, C A Bertulani, F Schindler, S Typel
An experimentally constrained equation of state of neutron-rich matter is fundamental for the physics of nuclei and the astrophysics of neutron stars, mergers, core-collapse supernova explosions, and the synthesis of heavy elements. To this end, we investigate the potential of constraining the density dependence of the symmetry energy close to saturation density through measurements of neutron-removal cross sections in high-energy nuclear collisions of 0.4 to 1 GeV/nucleon. We show that the sensitivity of the total neutron-removal cross section is high enough so that the required accuracy can be reached experimentally with the recent developments of new detection techniques...
December 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29328542/towards-the-detection-of-explosive-taggants-microwave-and-millimetre-wave-gas-phase-spectroscopies-of-3-nitrotoluene
#6
Anthony Roucou, Isabelle Kleiner, Manuel Goubet, Sabath Bteich, Gaël Mouret, Robin Bocquet, Francis Hindle, W Leo Meerts, Arnaud Cuisset
The monitoring of gas phase mononitrotoluenes is crucial for defence, civil security and environmental interests since they are used as taggant for TNT detection and in the manufacturing of industrial compounds such as dyestuffs. In this study, we have succeeded to measure and analyse at high resolution a room temperature rotationally resolved millimeter-wave spectrum of meta-nitrotoluene(3-NT). Experimental and theoretical difficulties have been overcome, in particular, those related to the low vapour pressure of 3-NT and to the presence of a CH$_3$ internal rotation in an almost free rotation regime ($V_3$=6...
January 12, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29327141/theoretical-study-on-benzoheterocycle-based-energetic-materials-effect-of-heterocyclic-fused-conjugation-hydrogen-bond-and-substitutional-group-on-the-detonation-performance
#7
Cheng Shen, Pengcheng Wang, Ming Lu
In this paper, four series of benzoheterocycle based energetic materials (EMs) have been designed to plan out a strategy to improve the density and safety of EMs, such as combining the insensitive group with aminobenzene ring and the high energetic nitramine explosives, benzo-heterocycle mother ring, designing multi-nitrogen heterocycles with a conjugated system containing N-N and C-N high energy bonds, and hydrogen bonding. Their optimized structure and detonation properties were first calculated and discussed using DFT methods...
January 11, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29326126/one-hundred-years-and-counting-of-blast-associated-traumatic-brain-injury
#8
EDITORIAL
Kevin Kinch, J L Fullerton, W Stewart
Blast-associated traumatic brain injury (TBI) has become one of the signature issues of modern warfare and is increasingly a concern in the civilian population due to a rise in terrorist attacks. Despite being a recognised feature of combat since the introduction of high explosives in conventional warfare over a century ago, only recently has there been interest in understanding the biology and pathology of blast TBI and the potential long-term consequences. Progress made has been slow and there remain remarkably few robust human neuropathology studies in this field...
January 10, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29324724/evaluation-of-oxidative-stress-levels-and-antioxidant-enzyme-activities-in-burst-fractures
#9
Fetullah Kuyumcu, Abdurrahman Aycan
BACKGROUND Spinal burst fractures are pathologies that occur in spinal injuries and cause significant mortality and morbidity as a result. Burst fractures in spinal cord injuries can result in rapid and significant oxidative stress. In addition to the primary injury in severe spinal cord injuries, subsequent secondary lesions are mainly due to inflammatory cascade activation and excessive production of free radicals. This study evaluated oxidative stress and antioxidant enzyme levels in burst fractures. MATERIAL AND METHODS Twenty patients with burst fractures were diagnosed and underwent surgery and 20 healthy control subjects were included in the study...
January 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29322913/cell-type-discovery-and-representation-in-the-era-of-high-content-single-cell-phenotyping
#10
Trygve Bakken, Lindsay Cowell, Brian D Aevermann, Mark Novotny, Rebecca Hodge, Jeremy A Miller, Alexandra Lee, Ivan Chang, Jamison McCorrison, Bali Pulendran, Yu Qian, Nicholas J Schork, Roger S Lasken, Ed S Lein, Richard H Scheuermann
BACKGROUND: A fundamental characteristic of multicellular organisms is the specialization of functional cell types through the process of differentiation. These specialized cell types not only characterize the normal functioning of different organs and tissues, they can also be used as cellular biomarkers of a variety of different disease states and therapeutic/vaccine responses. In order to serve as a reference for cell type representation, the Cell Ontology has been developed to provide a standard nomenclature of defined cell types for comparative analysis and biomarker discovery...
December 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29321621/functional-brain-network-mechanism-of-hypersensitivity-in-chronic-pain
#11
UnCheol Lee, Minkyung Kim, KyoungEun Lee, Chelsea M Kaplan, Daniel J Clauw, Seunghwan Kim, George A Mashour, Richard E Harris
Fibromyalgia (FM) is a chronic widespread pain condition characterized by augmented multi-modal sensory sensitivity. Although the mechanisms underlying this sensitivity are thought to involve an imbalance in excitatory and inhibitory activity throughout the brain, the underlying neural network properties associated with hypersensitivity to pain stimuli are largely unknown. In network science, explosive synchronization (ES) was introduced as a mechanism of hypersensitivity in diverse biological and physical systems that display explosive and global propagations with small perturbations...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321501/green-synthesis-of-graphene-oxide-by%C3%A2-seconds-timescale-water-electrolytic-oxidation
#12
Songfeng Pei, Qinwei Wei, Kun Huang, Hui-Ming Cheng, Wencai Ren
Graphene oxide is highly desired for printing electronics, catalysis, energy storage, separation membranes, biomedicine, and composites. However, the present synthesis methods depend on the reactions of graphite with mixed strong oxidants, which suffer from explosion risk, serious environmental pollution, and long-reaction time up to hundreds of hours. Here, we report a scalable, safe and green method to synthesize graphene oxide with a high yield based on water electrolytic oxidation of graphite. The graphite lattice is fully oxidized within a few seconds in our electrochemical oxidation reaction, and the graphene oxide obtained is similar to those achieved by the present methods...
January 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29321117/emergency-department-resuscitation-of-pediatric-trauma-patients-in-iraq-and-afghanistan
#13
Steven G Schauer, Guyon J Hill, Jason F Naylor, Michael D April, Matthew Borgman, Vikhyat S Bebarta
BACKGROUND: Military hospital healthcare providers treated children during the recent conflicts in Afghanistan and Iraq. Compared to adults, pediatric patients present unique challenges during trauma resuscitations and have notably been discussed in few research reports. We seek to describe ED interventions performed on pediatric trauma patients in Iraq and Afghanistan. METHODS: We queried the Department of Defense Trauma Registry (DODTR) for all pediatric patients in Iraq and Afghanistan from January 2007 to January 2016...
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29320863/evaluation-of-an-iterative-model-based-ct-reconstruction-algorithm-by-intra-patient-comparison-of-standard-and-ultra-low-dose-examinations
#14
Peter B Noël, Stephan Engels, Thomas Köhler, Daniela Muenzel, Daniela Franz, Michael Rasper, Ernst J Rummeny, Martin Dobritz, Alexander A Fingerle
Background The explosive growth of computer tomography (CT) has led to a growing public health concern about patient and population radiation dose. A recently introduced technique for dose reduction, which can be combined with tube-current modulation, over-beam reduction, and organ-specific dose reduction, is iterative reconstruction (IR). Purpose To evaluate the quality, at different radiation dose levels, of three reconstruction algorithms for diagnostics of patients with proven liver metastases under tumor follow-up...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29316764/-an-investigation-to-an-accident-of-occupational-trichloroethylene-explosion
#15
L J Yu, X D Jian, W J Wang, Y Z Wu, K Wang, J E Jia, Z C Zhang
Objective: To investigation to an accident of occupational trichloroethylene explosion and analyze the clinical datas. Methods: An investigation was carried out on the explosion of trichloroethylene in a place in shandong province in June 2016, and the clinical data of 4 patients with trichloroethylene poisoning were analyzed. Results: The incident is caused by irregularities in workers, 4 patients were characterized by different levels of the respiratory system, nervous system, liver, and skin lesions. Among them, respiratory system damage was more prominent, mainly manifested as chemical bronchitis and pneumonia, after positive rescue and treatment all recovered and discharged...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29316760/-analysis-on-occupational-noise-induced-hearing-loss-of-different-type-workers-in-underground-mining
#16
Q C Liu, C H Duo, Z Wang, K Yan, J Zhang, W Xiong, M Zhu
Objective: To investigate hearing loss status of blasters, drillers mechanics and so on in underground mining, and put forward suggestion diagnosis of occupational explosive deafness and occupational deafness. Methods: Underground excavation workers in a metal mine were recruited in this study, those with a history of ear disease and non-occupational deafness were all excluded. Finally, the features of pure tone audiometry of 459 noise-exposed workers were analyzed. Results: High-frequency hearing loss occurred on 351workers and the positive detection rate was 74...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29316123/from-designing-the-molecules-of-life-to-designing-life-future-applications-derived-from-advances-in-dna-technologies
#17
Richie E Kohman, Aditya M Kunjapur, Eriona Hysolli, Yu Wang, George M Church
Since the elucidation of its structure, DNA has been at the forefront of biological research. In the past half century, an explosion of DNA-based technology development has occurred with the most rapid advances being made for DNA sequencing. In parallel, dramatic improvements have also been made in the synthesis and editing of DNA from the oligonucleotide to the genome scale. In this Review, we will summarize four different subfields relating to DNA technologies following this trajectory of smaller to larger scale...
January 9, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29316117/c8n26h4-an-environmentally-friendly-primary-explosive-with-high-heat-of-formation
#18
Dan Chen, Hongwei Yang, Zhenxin Yi, Hualin Xiong, Lin Zhang, Shunguan Zhu, Guangbin Cheng
This study presents the synthesis and characterization of the new metal-free polyazido compounds 3,6-bis-(2-(4,6-diazido-1,3,5-triazin-2-yl)-hydrazinyl)-1,2,4,5-tetrazine (2) and 3,6-bis-(2-(4,6-diazido-1,3,5-triazin-2-yl)-diazenyl)-1,2,4,5-tetrazine (4). Two compounds were characterized by NMR spectra, IR spectroscopy, mass spectrometry, and differential scanning calorimetry (DSC). Additionally, the structure of title compound 2 was confirmed by single crystal X-ray diffraction. Compounds 2 and 4 exhibit measured densities (1...
January 8, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29315383/multiple-intraintestinal-signals-coordinate-the-regulation-of-vibrio-cholerae-virulence-determinants
#19
Kenneth M Peterson, Patrick S Gellings
Vibrio cholerae is a gram-negative motile bacterium capable of causing fatal pandemic disease in humans via oral ingestion of contaminated water or food. Within the human intestine the motile vibrios must evade the innate host defense mechanisms, penetrate the mucus layer covering the small intestine, adhere to and multiply on the surface of the microvilli and cause disease via the action of cholera toxin. The explosive diarrhea associated with V. cholerae intestinal colonization leads to dissemination of the vibrios back into the environment to complete this phase of the life cycle...
January 5, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29315224/the-zika-virus-epidemic-in-brazil-from-discovery-to-future-implications
#20
REVIEW
Rachel Lowe, Christovam Barcellos, Patrícia Brasil, Oswaldo G Cruz, Nildimar Alves Honório, Hannah Kuper, Marilia Sá Carvalho
The first confirmed case of Zika virus infection in the Americas was reported in Northeast Brazil in May 2015, although phylogenetic studies indicate virus introduction as early as 2013. Zika rapidly spread across Brazil and to more than 50 other countries and territories on the American continent. The Aedesaegypti mosquito is thought to be the principal vector responsible for the widespread transmission of the virus. However, sexual transmission has also been reported. The explosively emerging epidemic has had diverse impacts on population health, coinciding with cases of Guillain-Barré Syndrome and an unexpected epidemic of newborns with microcephaly and other neurological impairments...
January 9, 2018: International Journal of Environmental Research and Public Health
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