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https://www.readbyqxmd.com/read/29779258/hyperpolarized-porous-silicon-nanoparticles-potential-theragnostic-material-for-%C3%A2-%C3%A2-si-magnetic-resonance-imaging
#1
Hyeonglim Seo, Ikjang Choi, Nicholas Whiting, Jingzhe Hu, Quy Son Luu, Shivanand Pudakalakatti, Caitlin McCowan, Yaewon Kim, Niki Zacharias, Seunghyun Lee, Pratip Bhattacharya, Youngbok Lee
Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for ²⁹Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their ²⁹Si MR signals; the particles demonstrated long ²⁹Si spin-lattice relaxation (T₁) times (~ 25 mins), which suggests potential applicability for medical imaging...
May 20, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29779150/disorienting-dilemmas-the-significance-of-resistance-and-disturbance-in-an-intercultural-program-within-kindergarten-teacher-education
#2
Åsta Birkeland, Siv Ødemotland
As the Norwegian society, and thereby the kindergartens, have become more multicultural, the need for cultivating teachers capable of operating in an ever diversified and global world is highlighted as an important educational strategy within teacher education. The purpose of the specific intercultural program in kindergarten teacher education discussed in this article refers to competences needed as a professional teacher in a multicultural kindergarten. Teachers often have various assumptions and beliefs taken for granted...
May 19, 2018: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/29779127/physiological-and-transcriptomic-analysis-of-a-chronologically-long-lived-saccharomyces-cerevisiae-strain-obtained-by-evolutionary-engineering
#3
Mevlüt Arslan, Can Holyavkin, Halil İbrahim Kısakesen, Alican Topaloğlu, Yusuf Sürmeli, Zeynep Petek Çakar
High-throughput aging studies with yeast as a model organism involve transposon-mutagenesis and yeast knockout collection, which have been pivotal strategies for understanding the complex cellular aging process. In this study, a chronologically long-lived Saccharomyces cerevisiae mutant was successfully obtained by using another high-throughput approach, evolutionary engineering, based on systematic selection in successive batch cultures under gradually increasing levels of caloric restriction. Detailed comparative physiological and transcriptomic analyses of the chronologically long-lived mutant and the reference strain revealed enhanced levels of respiratory metabolism, upregulation of genes related to carbohydrate metabolic processes, glycogen-trehalose pathways, stress response, and repression of protein synthesis-related genes in the long-lived mutant SRM11, already in the absence of caloric restriction...
May 19, 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29779094/-cell-grafting-a-new-approach-for-transferring-cytoplasmic-or-nuclear-genome-between-plants
#4
Vladimir Sidorov, Charles Armstrong, Thomas Ream, Xudong Ye, Annie Saltarikos
A new method based on mixing and wounding of callus tissue was used to transfer plastid or nuclear DNA between cells. Methods alternative to sexual hybridization can be powerful tools for crop improvement. We have developed a new hybridization technology based on wounding a mixed population of cells of two parents growing in vitro as callus ("cell grafting"), and have demonstrated the utility of this system for plastid or nuclear genome transfer. In our proof-of concept experiments, non-organized growing tissue (callus) from tobacco var...
May 19, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29779012/adaptive-frameworks-of-chronic-pain-daily-remakings-of-pain-and-care-at-a-somali-refugee-women-s-health-centre
#5
Kari Campeau
Pain is an intensely subjective experience and one that is difficult for healthcare professionals to treat. Chronic pain, often diffuse, cyclical and involving many systems of the body, is often not well treated in a medical system that relies on discrete symptoms, identifiable causes, external pathogens and physician specialisation. Pain has its own problems specific to Somali diaspora populations, where chronic pain is prevalent but often undertreated, and where Somali patients face barriers of access to medicine...
May 19, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29778897/measurement-of-ambient-dose-equivalent-rates-by-walk-survey-around-fukushima-dai-ichi-nuclear-power-plant-using-kurama-ii-until-2016
#6
Masaki Andoh, Hideaki Yamamoto, Takashi Kanno, Kimiaki Saito
Ambient dose equivalent rates in various environments related to human lives were measured by walk surveys using the KURAMA-II systems from 2013 to 2016 within an 80-km radius of the Fukushima Dai-ichi Nuclear Power Plant. The dose rate of the locations where the walk survey was performed decreased to about 38% of its initial value in the 42 months from June 2013 to the December 2016, which was beyond that attributable to the physical decay of radiocaesium. The ecological half-life of the slow decreasing component was evaluated to be 4...
May 17, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29778857/development-of-a-risk-score-based-on-aortic-calcification-to-predict-1-year-mortality-after-transcatheter-aortic-valve-replacement
#7
Pierre Lantelme, Hélène Eltchaninoff, Muriel Rabilloud, Géraud Souteyrand, Marion Dupré, Marco Spaziano, Marc Bonnet, Clément Becle, Benjamin Riche, Eric Durand, Erik Bouvier, Jean-Nicolas Dacher, Pierre-Yves Courand, Lucie Cassagnes, Eduardo E Dávila Serrano, Pascal Motreff, Loic Boussel, Thierry Lefèvre, Brahim Harbaoui
OBJECTIVES: The aim of this study was to develop a new scoring system based on thoracic aortic calcification (TAC) to predict 1-year cardiovascular and all-cause mortality. BACKGROUND: A calcified aorta is often associated with poor prognosis after transcatheter aortic valve replacement (TAVR). A risk score encompassing aortic calcification may be valuable in identifying poor TAVR responders. METHODS: The C4 CAPRI (4 Cities for Assessing CAlcification PRognostic Impact) multicenter study included a training cohort (1,425 patients treated using TAVR between 2010 and 2014) and a contemporary test cohort (311 patients treated in 2015)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778773/effects-of-electronic-cigarette-liquid-solvents-propylene-glycol-and-vegetable-glycerin-on-user-nicotine-delivery-heart-rate-subjective-effects-and-puff-topography
#8
Tory R Spindle, Soha Talih, Marzena M Hiler, Nareg Karaoghlanian, Matthew S Halquist, Alison B Breland, Alan Shihadeh, Thomas Eissenberg
BACKGROUND: Electronic cigarettes (ECIGs) are a class of tobacco products that produce different effects (e.g., nicotine delivery), depending on the device, liquid, and behavioral factors. However, the influence of the two primary ECIG liquid solvents, propylene glycol (PG) and vegetable glycerin (VG), on ECIG acute effects is unknown. METHODS: Thirty ECIG-experienced, ≥12-h nicotine- abstinent participants completed four conditions consisting of two ECIG-use bouts (10 puffs, 30 s interpuff-interval) differing only by liquid PG:VG ratio (2PG:98VG, 20PG:80VG, 55PG:45VG, 100PG)...
May 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29778763/oscillation-patterns-of-local-field-potentials-in-the-dorsal-striatum-and-sensorimotor-cortex-during-the-encoding-maintenance-and-decision-stages-for-the-ordinal-comparison-of-sub-and-supra-second-signal-durations
#9
REVIEW
Bon-Mi Gu, Keshav Kukreja, Warren H Meck
Ordinal comparison of successively presented signal durations requires a) the encoding of the first signal duration (standard), b) maintenance of temporal information specific to the standard duration in memory, and c) timing of the second signal duration (comparison) during which a comparison is made of the first and second durations. Rats were first trained to make ordinal comparisons of signal durations within three time ranges using 0.5, 1.0, and 3.0-s standard durations. Local field potentials were then recorded from the dorsal striatum and sensorimotor cortex in order to investigate the pattern of neural oscillations during each phase of the ordinal-comparison process...
May 17, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29778708/fluorescence-resonance-energy-transfer-of-caf-2-eu-2-tb-3-applied-to-dye-sensitized-solar-cells
#10
Lege Wang, Zijian Yang, You-Fen Li, Ru Yang, Zhigang Dai, Shuqiao Hu, Liangliang Sun, Yaoyao Tong
CaF2 : Eu2+ , Tb3+ introduced into dye-sensitized solar cells (DSSCs) were studied to examine the influence of luminescent materials on photoanodes using a simple method. The emission spectra of CaF2 : Eu2+ , Tb3+ included the blue light of Eu2+ (4f → 5d) at 430 nm and green emission of Tb3+ (5 D4  → 7 F5 ) at 542 nm under the monitoring wavelengths at 398 nm, which matched well the absorption range of the N719 dye in DSSCs. Energy transfer (ET) was verified between Eu2+ and Tb3+ ions and the efficiency of ET found to increase with Tb3+ concentration...
May 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29778692/two-dimensional-distribution-measurement-of-electric-current-generated-in-a-polymer-electrolyte-fuel-cell-using-49-nmr-surface-coils
#11
Kuniyasu Ogawa, Tatsuyoshi Sasaki, Shigeki Yoneda, Kumiko Tsujinaka, Ritsuko Asai
In order to increase the current density generated in a PEFC (polymer electrolyte fuel cell), a method for measuring the spatial distribution of both the current and the water content of the MEA (membrane electrode assembly) is necessary. Based on the frequency shifts of NMR (nuclear magnetic resonance) signals acquired from the water contained in the MEA using 49 NMR coils in a 7 × 7 arrangement inserted in the PEFC, a method for measuring the two-dimensional spatial distribution of electric current generated in a unit cell with a power generation area of 140 mm × 160 mm was devised...
May 17, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29778685/methodology-of-spatial-risk-assessment-for-arsenic-species-associated-with-sampling-and-analysis-results-optimization
#12
Yimei Zhang, Liqun Wang, Jie Chen, Yalong Zhao, Yuxian Lai, Panpan Wu
The conventional risk assessment methods may be defective for more effective health risk assessment due to ignoring heavy metal species and the accuracy and integrity of sampling and analysis results. Using the accurate and integral data to quantify the human health effects of metal species can provide great support for more effective health risk assessment. This study presents a new methodology to optimize sampling and analysis results for implementing the spatial human health risk of heavy metal species in contaminated sites...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#13
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29778665/a-novel-system-to-quantify-intestinal-lipid-digestion-and-transport
#14
Øystein Sæle, Kari Elin L Rød, Vanessa H Quinlivan, Shengrong Li, Steven A Farber
The zebrafish larva is a powerful tool for the study of dietary triglyceride (TG) digestion and how fatty acids (FA) derived from dietary lipids are absorbed, metabolized and distributed to the body. While fluorescent FA analogues have enabled visualization of FA metabolism, methods for specifically assaying TG digestion are badly needed. Here we present a novel High Performance Liquid Chromatography (HPLC) method that quantitatively differentiates TG and phospholipid (PL) molecules with one or two fluorescent FA analogues...
May 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29778642/benefits-of-a-multicomponent-falls-unit-based-exercise-program-in-older-adults-with-falls-in-real-life
#15
Rafael García Molina, Marta Carolina Ruíz Grao, Alicia Noguerón García, Marta Martínez Reig, Mariano Esbrí Víctor, Míkel Izquierdo Redín, Pedro Abizanda Soler
BACKGROUND/OBJECTIVES: Multicomponent exercise programs are the cornerstone in preventing gait and balance impairments and falls in older adults. However, the effects of these programs in usual clinical practice have been poorly analyzed. DESIGN: 4-Month, twice-a-week multicomponent exercise program cohort study in real-life. SETTING: Falls Unit, Complejo Hospitalario Universitario of Albacete, Spain. PARTICIPANTS: Sixty-seven participants who had experienced a fall in the previous year were included...
May 17, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29778458/noninvasive-diagnosis-of-endometriosis-review-of-current-peripheral-blood-and-endometrial-biomarkers
#16
REVIEW
Dorien F O, Idhaliz Flores, Etienne Waelkens, Thomas D'Hooghe
A noninvasive biomarker-based test could help shorten the diagnostic delay for endometriosis. The most investigated biomarker sources are peripheral blood and endometrium. Discovery of endometriosis biomarkers is often hypothesis-driven, i.e. when one or a few biomarkers are investigated based on their role in the disease pathogenesis. Alternatively, a hypothesis-generating approach has been followed using the "omics" technologies. A variety of biomarkers for endometriosis have been investigated, but no biomarker has been validated for clinical use...
April 13, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29778404/plasma-assisted-synthesis-of-%C3%AE-alumina-from-waste-aluminium-dross
#17
R Saravanakumar, K Ramachandran, Lintu G Laly, P V Ananthapadmanabhan, S Yugeswaran
Aluminium dross, a waste generated from aluminium melting process, contains aluminium metal, aluminium oxide, aluminium oxy-nitride and impurities such as sodium chloride and potassium chloride. Since aluminium dross is land filled without treatment, it is hazardous to the environment. Conventional methods for the metal recovery from the recycling of aluminium dross involve chemicals and are time consuming. In this study, an attempt was made to treat aluminium dross using plasma arc melting process. The aluminium dross was melted and evaporated by the plasma arc established between a crucible anode and a rod type hollow cathode made of graphite...
May 16, 2018: Waste Management
https://www.readbyqxmd.com/read/29778384/association-of-birth-defects-with-the-mode-of-assisted-reproductive-technology-in-a-chinese-data-linkage-cohort
#18
Hui-Ting Yu, Qing Yang, Xiao-Xi Sun, Guo-Wu Chen, Nai-Si Qian, Ren-Zhi Cai, Han-Bing Guo, Chun-Fang Wang
OBJECTIVE: To evaluate the impact of assisted reproductive technology (ART) on the offspring of Chinese population. DESIGN: Retrospective, data-linkage cohort. SETTING: Not applicable. PATIENT(S): Live births resulting from ART or natural conception. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Birth defects coded according to ICD-10. RESULT(S): Births after ART were more likely to be female and multiple births, especially after intracytoplasmic sperm injection (ICSI)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778382/comparison-of-the-prevalence-of-chronic-endometritis-as-determined-by-means-of-different-diagnostic-methods-in-women-with-and-without-reproductive-failure
#19
Yingyu Liu, Xiaoyan Chen, Jin Huang, Chi-Chiu Wang, Mei-Yung Yu, Susan Laird, Tin-Chiu Li
OBJECTIVE: To compare the prevalence of chronic endometritis (CE) when different diagnostic methods are used. DESIGN: Prospective observational study. SETTING: University-affiliated hospital. PATIENT(S): Four groups of women were studied, including women with proven fertility (Fertile; n = 40), unexplained recurrent miscarriage (RM; n = 93), recurrent implantation failure (RIF; n = 39), and infertile subjects undergoing endometrial scratch in a natural cycle preceding frozen-thawed embryo transfer (Infertility; n = 48)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778346/energy-performance-evaluation-of-ultrasonic-pretreatment-of-organic-solid-waste-in-a-pilot-scale-digester
#20
Mazdak Rasapoor, Mehrdad Adl, Saeid Baroutian, Zeynab Iranshahi, Mohammad Pazouki
It has been proven that ultrasonic pretreatment (UP) has positive effect on biogas generation from previous lab-scale studies. However, that is not always the case in larger scale processes. The purpose of this study was to evaluate the effectiveness of UP to biogas generation in terms of anaerobic digestion process and energy efficiency. Parameters including total solids (TS) and ultrasonic treatment operational parameters of organic solid waste (OSW) resulted from our past lab scale UP studies were applied in this study...
April 30, 2018: Ultrasonics Sonochemistry
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