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Sora Yoon, Hai C T Nguyen, Yun J Yoo, Jinhwan Kim, Bukyung Baik, Sounkou Kim, Jin Kim, Sangsoo Kim, Dougu Nam
Pathway-based analysis in genome-wide association study (GWAS) is being widely used to uncover novel multi-genic functional associations. Many of these pathway-based methods have been used to test the enrichment of the associated genes in the pathways, but exhibited low powers and were highly affected by free parameters. We present the novel method and software GSA-SNP2 for pathway enrichment analysis of GWAS P-value data. GSA-SNP2 provides high power, decent type I error control and fast computation by incorporating the random set model and SNP-count adjusted gene score...
March 19, 2018: Nucleic Acids Research
Madeleine S Power, Neil Small, Bob Doherty, Barbara Stewart-Knox, Kate E Pickett
Food insecurity is a determinant of maternal health; however, research on the health impact of food insecurity among mothers of varying ethnicities is under-developed. We assessed the association of food insecurity and health among white British and Pakistani mothers. Data from the Born in Bradford cohort were matched with data on food insecurity and self-reported health from the nested BiB1000 study (N = 1280). Food insecurity was associated with elevated odds of fair/poor health among white British mothers but not Pakistani mothers...
March 19, 2018: European Journal of Public Health
William H Curley, Peter B Forgacs, Henning U Voss, Mary M Conte, Nicholas D Schiff
Patients with severe brain injury are difficult to assess and frequently subject to misdiagnosis. 'Cognitive motor dissociation' is a term used to describe a subset of such patients with preserved cognition as detected with neuroimaging methods but not evident in behavioural assessments. Unlike the locked-in state, cognitive motor dissociation after severe brain injury is prominently marked by concomitant injuries across the cerebrum in addition to limited or no motoric function. In the present study, we sought to characterize the EEG signals used as indicators of cognition in patients with disorders of consciousness and examine their reliability for potential future use to re-establish communication...
March 19, 2018: Brain: a Journal of Neurology
Wei Liu, Guanghui Han, Yalin Yin, Shuai Jiang, Guojun Yu, Qing Yang, Wenhui Yu, Xiangdong Ye, Yanting Su, Yajun Yang, Gerald W Hart, Hui Sun
O-linked N-acetylglucosamine (O-GlcNAcylation) is an important post-translational modification on serine or threonine of proteins, mainly observed in nucleus or cytoplasm. O-GlcNAcylation regulates many cell processes, including transcription, cell cycle, neural development, and nascent polypeptide chains stabilization. However, the facile identification of O-GlcNAc is a major bottleneck in O-GlcNAcylation research. Herein, we report that a lectin, AANL (Agrocybe aegerita GlcNAc specific lectin), also reported as AAL2, can be used as a powerful probe for O-GlcNAc identification...
March 19, 2018: Glycobiology
E A Elgindy, H Sibai, M I Mostafa, A Gibreel, E Darwish, H Maghraby
STUDY QUESTION: In ICSI patients with high risk of ovarian hyperstimulation syndrome (OHSS), are antagonist cycles triggered by gonadotropin releasing hormone (GNRH) agonist with a specialized luteal support regimen associated with comparable ongoing pregnancy rate (OPR) and less OHSS than those triggered by hCG? SUMMARY ANSWER: In antagonist ICSI cycles, GnRH agonist triggering with a specialized luteal support regimen is associated with comparable OPR to those triggered by hCG but may be less likely to be associated with OHSS...
March 19, 2018: Human Reproduction
Skyler L Jackman, Christopher H Chen, Selmaan N Chettih, Shay Q Neufeld, Iain R Drew, Chimuanya K Agba, Isabella Flaquer, Alexis N Stefano, Thomas J Kennedy, Justine E Belinsky, Keiramarie Roberston, Celia C Beron, Bernardo L Sabatini, Christopher D Harvey, Wade G Regehr
Optical methods of interrogating neural circuits have emerged as powerful tools for understanding how the brain drives behaviors. Optogenetic proteins are widely used to control neuronal activity, while genetically encoded fluorescent reporters are used to monitor activity. These proteins are often expressed by injecting viruses, which frequently leads to inconsistent experiments due to misalignment of expression and optical components. Here, we describe how silk fibroin films simplify optogenetic experiments by providing targeted delivery of viruses...
March 20, 2018: Cell Reports
Seiichiro Amemiya, A David Redish
During decision making, hippocampal activity encodes information sometimes about present and sometimes about potential future plans. The mechanisms underlying this transition remain unknown. Building on the evidence that gamma oscillations at different frequencies (low gamma [LG], 30-55 Hz; high gamma [HG], 60-90 Hz; and epsilon, 100-140 Hz) reflect inputs from different circuits, we identified how changes in those frequencies reflect different information-processing states. Using a unique noradrenergic manipulation by clonidine, which shifted both neural representations and gamma states, we found that future representations depended on gamma components...
March 20, 2018: Cell Reports
Rémi Bos, Ronald M Harris-Warrick, Cécile Brocard, Liliia E Demianenko, Marin Manuel, Daniel Zytnicki, Sergiy M Korogod, Frédéric Brocard
Spinal motoneurons are endowed with nonlinear spiking behaviors manifested by a spike acceleration whose functional significance remains uncertain. Here, we show in rodent lumbar motoneurons that these nonlinear spiking properties do not rely only on activation of dendritic nifedipine-sensitive L-type Ca2+ channels, as assumed for decades, but also on the slow inactivation of a nifedipine-sensitive K+ current mediated by Kv1.2 channels that are highly expressed in axon initial segments. Specifically, the pharmacological and computational inhibition of Kv1...
March 20, 2018: Cell Reports
Yanbing Zhai, Siyu Liu, Lijuan Gao, Lili Hu, Wei Xu
With improved performances, miniature mass spectrometers are becoming suitable for more practical applications. At the same time, the coupling of an approximate ionization source is essential in terms of minimizing sample preparation and broadening the range of samples that could be analyzed. In this study, an atmospheric pressure laserspray ionization (AP-LSI) source was coupled with our home developed miniature ion trap mass spectrometer. The whole system is compact in size, and biological samples could be directly analyzed with minimum sample preparation...
March 21, 2018: Analytical Chemistry
Manoel Vieira de Miranda Neto, Talita Rewa, Valéria Marli Leonello, Maria Amélia de Campos Oliveira
OBJECTIVE: Reflect on the role of advanced practice nursing (APN) in the context of Brazilian primary health care. METHOD: analysis of the main scientific productions and of the discussion on the implementation of APN. RESULTS: there are favorable areas for the work of APN in primary health care, especially in the family health strategy. Professional master's degree and nurse residency programs constitute powerful training spaces. As a challenge, standardized definition of the roles of advanced practice nurses and of minimum training for work are necessary...
2018: Revista Brasileira de Enfermagem
Maria Amélia de Campos Oliveira, Tharsila Martins Rios da Silva
Inequalities are the result of the different positions held by individuals in different social spaces, and are related to the distribution of power and property. Health advocacy is a strategy to reduce such inequalities, especially those considered unfair and unnecessary, aiming to fully promote the right to health. This study aims to discuss the contribution of nursing in the field of health advocacy, which includes the right of everyone to a healthy life as one of the strategies for the reorientation of the Brazilian healthcare model...
2018: Revista Brasileira de Enfermagem
Cynthia de Jesus Freire, Lucas Roberto da Silva Barbosa, João Gomes da Costa, Renata Guerda de Araújo Santos, Aldenir Feitosa Dos Santos
OBJECTIVE: To demonstrate the use of phytotherapy as a therapy adopted in the context of Primary Care to Childhood. METHOD: Observational and analytical field research, with quantitative-qualitative approach. A semi-structured survey was used on socio-demographic and ethnopharmacological variables, audio interview and daily observation. RESULTS: The production of knowledge about phytotherapy constitutes a family heritage, but incorporated data resulting from the daily experiences shared by the community...
2018: Revista Brasileira de Enfermagem
Angela Maria Gomes, Liane Colliselli, Maria Elisabeth Kleba, Valéria Silvana Faganello Madureira
OBJECTIVE: to identify the participation dynamics of a municipal council and to develop a critical-reflexive process on "being a counselor", identifying weaknesses and possibilities of this council, in addition to collectively generating new knowledge and (re)elaborating the MHC Ordinary Law. METHOD: Convergent care research, including documentary analysis, non-participant observation and thematic workshops. The research was carried out in 2016, with municipal health counselors from a city in the Western Region of Santa Catarina...
2018: Revista Brasileira de Enfermagem
(no author information available yet)
No abstract text is available yet for this article.
2018: PloS One
Qi Wu, Tomotaka Ogasawara, Nobuhiro Yoshikawa, Hongzhou Zhai
Amorphous thermoplastics, as a type of engineering plastic material, are used in various industrial sectors. In order to manufacture high-performance products, it is important to optimize their forming process to mitigate residual stresses. However, stress in a plate is difficult to measure, therefore, modeling provides a powerful way to investigate and understand the evolution of stress. In this study, the forming process of a polyetherimide (PEI) plate was modelled using finite element analysis, and then validated through a comparison with a warpage experiment...
March 21, 2018: Materials
Shaoran Yang, Kaili Zhang
Carbon materials derived from biomass are promising electrode materials for supercapacitor application due to their specific porosity, low cost and electrochemical stability. Herein, a hierarchical porous carbon derived from corncob was developed for use as electrodes. Benefitting from its hierarchical porosity, inherited from the natural structure of corncob, high BET surface area (1471.4 m²·g-1 ) and excellent electrical conductivity, the novel carbon material exhibited a specific capacitance of 293 F·g-1 at 1 A·g-1 in 6 M KOH electrolyte and maintained at 195 F·g-1 at 5 A·g-1 ...
March 21, 2018: Nanomaterials
Ramanaskanda Braveenth, Il-Ji Bae, Ji-Hun Han, Wu Qiong, Guk Seon, Kanthasamy Raagulan, Kihun Yang, Young Hee Park, Miyoung Kim, Kyu Yun Chai
Two new hole transporting materials, 2,7-bis(9,9-diphenylacridin-10(9 H )-yl)-9,9' spirobi[fluorene] (SP1) and 2,7-di(10 H -phenothiazin-10-yl)-9,9'-spirobi[fluorene] (SP2), were designed and synthesized by using the Buchwald-Hartwig coupling reaction with a high yield percentage of over 84%. Both of the materials exhibited high glass transition temperatures of over 150 °C. In order to understand the device performances, we have fabricated green phosphorescent organic light-emitting diodes (PhOLEDs) with SP1 and SP2 as hole transporting materials...
March 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
João Paulo Limongi França Guilherme, Mariana Sussi Silva, Rômulo Bertuzzi, Antonio Herbert Lancha Junior
The main purpose of this study was to investigate if the rs11091046 (A>C) polymorphism in AGTR2 gene is associated with athletic status in top-level athletes from Brazil. Since the AGTR2 gene is located on the X chromosome, the case-control association study was done separately for women and men. The female cohort was composed of 205 athletes and 241 non-athletes, and the male cohort was composed of 419 athletes and 490 non-athletes. We did not identify an association between the C-allele and the endurance phenotype...
March 21, 2018: Journal of Sports Sciences
Robert Galinsky, Simerdeep K Dhillon, Christopher A Lear, Kyohei Yamaguchi, Guido Wassink, Alistair J Gunn, Laura Bennet
Magnesium sulfate (MgSO4 ) is recommended for preterm neuroprotection, preeclampsia and preterm labor prophylaxis. There is an important unmet need to carefully test clinical interventions in both sexes. Therefore, we aimed to investigate cardiovascular and neurophysiological adaptations to MgSO4 during normoxia and asphyxia in preterm male and female fetal sheep. Fetuses were instrumented at 98{plus minus}1 days of gestation (d; term=147 d). At 104 d, unanaesthetised fetuses were randomly assigned to intravenous MgSO4 (n=12 F, 10 M) or saline (n=13 F, 10 M)...
March 21, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Joseph M Kasper, Patrick J Lestrange, Torin F Stetina, Xiaosong Li
X-ray absorption spectroscopy is a powerful technique to probe local electronic and nuclear structure. There has been extensive theoretical work modeling K-edge spectra from first principles. However, modeling L-edge spectra directly with density functional theory poses a unique challenge requiring further study. Spin-orbit coupling must be included in the model and a non-collinear density functional theory is required. Using the real-time exact two-component method we are able to variationally include one-electron spin-orbit coupling terms when calculating the absorption spectrum...
March 21, 2018: Journal of Chemical Theory and Computation
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