keyword
MENU ▼
Read by QxMD icon Read
search

Ion mobility spectrometry

keyword
https://www.readbyqxmd.com/read/29166625/ambient-surface-mass-spectrometry-ion-mobility-spectrometry-of-intact-proteins
#1
REVIEW
Rian L Griffiths, Klaudia I Kocurek, Helen J Cooper
Ambient surface mass spectrometry encompasses a broad range of sampling and ionization techniques. To date, only a small subset of these, based on liquid microjunction extraction, have proven suitable for intact protein analysis from thin tissue sections. Liquid extraction surface analysis shows particular promise for this application. Recently, a range of ion mobility spectrometry approaches have been coupled with ambient mass spectrometry. Improvements in signal-to-noise ratios, decreased chemical noise and separation of molecular classes have been described for the analysis of various biological substrates...
November 18, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29166005/self-assembly-of-tetrameric-and-hexameric-terpyridine-based-macrocycles-using-cd-ii-zn-ii-and-fe-ii
#2
Lei Wang, Zhe Zhang, Xin Jiang, Jennifer A Irvin, Changlin Liu, Ming Wang, Xiaopeng Li
The self-assembly behavior of a tritopic 2,2':6',2″-terpyridine (tpy) ligand with Cd(II), Zn(II), and Fe(II) has been exploited herein to generate a series of tetrameric and hexameric macrocycles. The main advantage of using such transition metals with an octahedral coordination geometry is their distinct coordination abilities (e.g., binding strength and reversibility). With the same ligand, this study reveals that the supramolecular structural variation between tetrameric and hexameric macrocycle architectures can be precisely controlled using different metal ions with the same coordination geometry...
November 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29161611/the-application-of-ion-mobility-mass-spectrometry-to-metabolomics
#3
REVIEW
Xing Zhang, Kevin Quinn, Charmion Cruickshank-Quinn, Richard Reisdorph, Nichole Reisdorph
Mass spectrometry-based metabolomics is being increasingly utilized in various research fields including investigating human diseases, nutrition, industrial applications, and plant/natural products studies. Although new analytical approaches have enhanced the performance of metabolomic analyses, significant challenges associated with throughput, metabolome coverage, and compound identification still exist. Ion mobility mass spectrometry offers great potential for improving throughput and depth of coverage in metabolomics experiments...
November 18, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29161511/a-customizable-flow-injection-system-for-automated-high-throughput-and-time-sensitive-ion-mobility-spectrometry-and-mass-spectrometry-measurements
#4
Daniel J Orton, Malak M Tfaily, Ronald J Moore, Brian L LaMarche, Xueyun Zheng, Thomas L Fillmore, Rosalie K Chu, Karl K Weitz, Matthew E Monroe, Ryan T Kelly, Richard D Smith, Erin Shammel Baker
To better understand disease conditions and environmental perturbations, multi-omic studies combining proteomic, lipidomic, and metabolomic analyses are vastly increasing in popularity. In a multi-omic study, a single sample is typically extracted in multiple ways and various analyses are performed using different instruments. Thus, one sample becomes many measurements, making high throughput and reproducible evaluations a necessity. One way to address the numerous samples and varying instrumental conditions is to utilize a flow injection analysis (FIA) system for rapid sample injection...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29154177/fundamentals-of-ion-mobility-spectrometry
#5
REVIEW
Valérie Gabelica, Erik Marklund
Fundamental questions in ion mobility spectrometry have practical implications for analytical applications in general, and omics in particular, in three respects. (1) Understanding how ion mobility and collision cross section values depend on the collision gas, on the electric field and on temperature is crucial to ascertain their transferability across instrumental platforms. (2) Predicting collision cross section values for new analytes is necessary to exploit the full potential of ion mobility in discovery workflows...
November 15, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29146423/comprehensive-lipidomic-analysis-of-human-plasma-using-multidimensional-liquid-and-gas-phase-separations-two-dimensional-liquid-chromatography-mass-spectrometry-vs-liquid-chromatography-trapped-ion-mobility-mass-spectrometry
#6
Anna Baglai, Andrea F G Gargano, Jan Jordens, Ynze Mengerink, Maarten Honing, Sjoerd van der Wal, Peter J Schoenmakers
Recent advancements in separation science have resulted in the commercialization of multidimensional separation systems that provide higher peak capacities and, hence, enable a more-detailed characterization of complex mixtures. In particular, two powerful analytical tools are increasingly used by analytical scientists, namely online comprehensive two-dimensional liquid chromatography (LC×LC, having a second-dimension separation in the liquid phase) and liquid chromatography-ion mobility-spectrometry (LC-IMS, second dimension separation in the gas phase)...
November 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29145156/the-potential-of-ion-mobility-mass-spectrometry-for-high-throughput-and-high-resolution-lipidomics
#7
REVIEW
Christine Hinz, Sonia Liggi, Julian L Griffin
Lipids are a large and highly diverse family of biomolecules, which play essential structural, storage and signalling roles in cells and tissues. Although traditional mass spectrometry (MS) approaches used in lipidomics are highly sensitive and selective, lipid analysis remains challenging due to the chemical diversity of lipid structures, multiple isobaric species and incomplete separation using many forms of chromatography. Ion mobility (IM) separates ions in the gas phase based on their physicochemical properties...
November 13, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29145024/direct-analysis-of-ethylene-glycol-in-human-serum-on-the-basis-of-analyte-adduct-formation-and-liquid-chromatography-tandem-mass-spectrometry
#8
Marek Dziadosz
The aim of this work was to develop a fast, cost-effective and time-saving liquid chromatography-tandem mass spectrometry (LC-MS/MS) analytical method for the analysis of ethylene glycol (EG) in human serum. For these purposes, the formation/fragmentation of an EG adduct ion with sodium and sodium acetate was applied in the positive electrospray mode for signal detection. Adduct identification was performed with appropriate infusion experiments based on analyte solutions prepared in different concentrations...
November 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29140480/the-intrinsically-disordered-n-terminal-arm-of-the-brome-mosaic-virus-coat-protein-specifically-recognizes-the-rna-motif-that-directs-the-initiation-of-viral-rna-replication
#9
Alexander Jacobs, Haley Hoover, Edward Smith, David E Clemmer, Chul-Hyun Kim, C Cheng Kao
In the brome mosaic virus (BMV) virion, the coat protein (CP) selectively contacts the RNA motifs that regulate translation and RNA replication (Hoover et al., 2016. J. Virol. 90, 7748). We hypothesize that the unstructured N-terminal arm (NTA) of the BMV CP can specifically recognize RNA motifs. Using ion mobility spectrometry-mass spectrometry, we demonstrate that peptides containing the NTA of the CP were found to preferentially bind to an RNA hairpin motif that directs the initiation of BMV RNA synthesis...
November 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29136835/design-and-construction-of-an-injection-port-for-coupling-stir-bar-sorptive-extraction-with-ion-mobility-spectrometry
#10
Mohammad T Jafari, Mohammad R Rezayat, Mehdi Mossaddegh
An appropriate injection port was designed and constructed for direct analysis of stir-bar sorptive extractions using an ion mobility spectrometry (IMS). The novel design of the port offers great simplicity in use, high sensitivity, and high thermal and mechanical stability. The sol-gel technique was applied to prepare polydimethylsiloxane absorbent on a stir-bar. The parameters affecting extraction efficiency including stirring rate, extraction temperature, extraction time, salt addition and desorption temperature were optimized...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136580/advancing-the-large-scale-ccs-database-for-metabolomics-and-lipidomics-at-the-machine-learning-era
#11
REVIEW
Zhiwei Zhou, Jia Tu, Zheng-Jiang Zhu
Metabolomics and lipidomics aim to comprehensively measure the dynamic changes of all metabolites and lipids that are present in biological systems. The use of ion mobility-mass spectrometry (IM-MS) for metabolomics and lipidomics has facilitated the separation and the identification of metabolites and lipids in complex biological samples. The collision cross-section (CCS) value derived from IM-MS is a valuable physiochemical property for the unambiguous identification of metabolites and lipids. However, CCS values obtained from experimental measurement and computational modeling are limited available, which significantly restricts the application of IM-MS...
November 11, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29135234/evaluating-the-effect-of-phosphorylation-on-the-structure-and-dynamics-of-hsp27-dimers-by-means-of-ion-mobility-mass-spectrometry
#12
Blagojce Jovcevski, Megan A Kelly, J Andrew Aquilina, Justin L P Benesch, Heath Ecroyd
The quaternary structure and dynamics of the human small heat-shock protein Hsp27 is linked to its molecular chaperone function and influenced by post-translational modifications, including phosphorylation. Phosphorylation of Hsp27 promotes oligomer dissociation and can enhance chaperone activity. This study explored the impact of phosphorylation on the quaternary structure and dynamics of Hsp27. Using mutations that mimic phosphorylation and ion mobility mass spectrometry we show that successive substitutions result in an increase in the conformational heterogeneity of Hsp27 dimers...
November 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29131943/drift-tube-ion-mobility-how-to-reconstruct-collision-cross-section-distributions-from-arrival-time-distributions
#13
Adrien Marchand, Sandrine Livet, Frédéric Rosu, Valérie Gabelica
Ion mobility spectrometry allows one to determine ion collision cross sections, which are related to ion size and shape. Collision cross sections (CCS) are usually discussed based on the peak center, yet the width of each peak contains further information on the distribution of collision cross sections of each conformational ensemble. Here, we analyze how to convert arrival time distributions (ATD) to CCS distributions (CCSD). With a calibration curve taking into account the CCS dependence of the time spent outside the mobility region, one can reconstruct CCS distributions with correct peak center values...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29128914/simultaneous-determination-of-tolterodine-and-its-two-metabolites-5-hydroxymethyltolterodine-and-n-dealkyltolterodine-in-human-plasma-using-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#14
Young-Hoon Kim, Ji-Yeong Byeon, Se-Hyung Kim, Choong-Min Lee, Eui Hyun Jung, Won Ki Chae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Tolterodine is a nonselective muscarinic antagonist that is indicated for the overactive urinary bladder and other urinary difficulties. We developed and validated a simple, rapid and sensitive high-performance liquid chromatography analytical method utilizing tandem mass spectrometry (LC-MS/MS) for the quantitation of tolterodine and its major metabolites, 5-hydroxymethyltolterodine (5-HMT) and N-dealkyltolterodine (NDT), in human plasma. After liquid-liquid extraction with methyl t-butyl ether, chromatographic separation of the three analytes was achieved using a reversed-phase Luna Phenyl-hexyl column (100 × 2...
November 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29128665/the-application-of-ion-mobility-mass-spectrometry-for-structure-function-investigation-of-protein-complexes
#15
REVIEW
Gili Ben-Nissan, Michal Sharon
Ion-mobility mass spectrometry (IM-MS) is an approach that can provide information on the stoichiometry, composition, protein contacts and topology of protein complexes. The power of this approach lies not only in its sensitivity and speed of analysis, but also in the fact that it is a technique that can capture the repertoire of conformational states adopted by protein assemblies. Here, we describe the array of available IM-MS based tools, and demonstrate their application to the structural characterization of various protein complexes, including challenging systems as amyloid aggregates and membrane proteins...
November 8, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29128276/simultaneous-determination-of-saikosaponin-a-paeonol-and-imperatorin-components-of-da-9805-in-rat-plasma-by-lc-ms-ms-and-application-to-a-pharmacokinetic-study
#16
Mi Hye Kwon, Jin Seok Jeong, Jayoung Ryu, Young Woong Cho, Hee Eun Kang
DA-9805 is a new botanical antiparkinson drug candidate formulated using an ethanolic extract of the root of Bupleurum falcatum, the root cortex of Paeonia suffruticosa, and the root of Angelica dahurica. In this study, a sensitive and rapid LC-MS/MS method was developed to simultaneously determine, saikosaponin a, paeonol, and imperatorin, three active/representative ingredients of DA-9805, in rat plasma. Plasma was extracted by mixture of ethyl acetate and methyl tertiary butyl ether. Chromatographic separation was carried out using a C18 column and a gradient elution of mobile phases consisting of 5mM formic acid in water and acetonitrile...
November 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29127569/cooperative-formation-of-icosahedral-proline-clusters-from-dimers
#17
Alexander D Jacobs, K V Jovan Jose, Rachel Horness, Krishnan Raghavachari, Megan C Thielges, David E Clemmer
Ion mobility spectrometry-mass spectrometry and Fourier transform infrared spectroscopy (FTIR) techniques were combined with quantum chemical calculations to examine the origin of icosahedral clusters of the amino acid proline. When enantiopure proline solutions are electrosprayed (using nanospray) from 100 mM ammonium acetate, only three peaks are observed in the mass spectrum across a concentration range of five orders of magnitude: a monomer [Pro+H](+) species, favored from 0.001 to 0.01 mM proline concentrations; a dimer [2Pro+H](+) species, the most abundant species for proline concentrations above 0...
November 10, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29126587/dispersive-magnetic-immunoaffinity-extraction-anatoxin-a-determination
#18
Tinh Le, Francesc A Esteve-Turrillas, Sergio Armenta, Miguel de la Guardia, Guillermo Quiñones-Reyes, Antonio Abad-Fuentes, Antonio Abad-Somovilla
Specific monoclonal antibodies were coupled with magnetic Sepharose-based beads and used, for the first time. The methodology was applied to preconcentrate anatoxin-a from water and the later determination by ion mobility spectrometry (IMS). Dispersive magnetic immunoaffinity (d-MagIA) extraction methodology provided a limit of detection of 0.02μgL(-1) and a satisfactory precision with a relative standard deviation lower than 15%. Recoveries were evaluated at 0.5, 1.0 and 5.0μgL(-1) anatoxin-a with quantitative values from 91 to 115%...
November 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29126083/hplc-uv-ms-method-application-for-the-separation-of-obeticholic-acid-and-its-related-compounds-in-development-process-and-quality-control
#19
Michal Douša, Markéta Slavíková, Tomáš Kubelka, Josef Černý, Petr Gibala, Josef Zezula
An HPLC method with UV and electrospray ionization - mass spectrometry (ESI-MS) detection was developed for the separation and determination of obeticholic acid (OBE) and its related compounds in development process and quality control. OBE and its related compounds were classified into three major group based on the mass spectra profiles: (A) those containing a hydroxyl group at position 3 and 7, (B) those containing a hydroxyl group and/or carbonyl group at position 3, hydrogen, ethyl or ethylidene group at position 6 and a hydroxyl group and/or carbonyl group at position 7, and (C) those containing carbonyl groups at position 3 and 7...
November 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29120785/identification-and-characterization-of-pesticide-metabolites-in-brassica-species-by-liquid-chromatography-travelling-wave-ion-mobility-quadrupole-time-of-flight-mass-spectrometry-uplc-twims-qtof-ms
#20
Anna Bauer, Jens Luetjohann, Franziska S Hanschen, Monika Schreiner, Jürgen Kuballa, Eckard Jantzen, Sascha Rohn
A new mass spectrometric method for evaluating metabolite formation of the pesticides thiacloprid, azoxystrobin, and difenoconazole was developed for the Brassica species pak choi and broccoli. Both, distribution and transformation kinetics of the active compounds and their metabolites were analyzed by UPLC-TWIMS-QTOF-MS. Additionally, HR-MS analysis and structure elucidation tools such as diagnostic ions, isotopic matches, and collision cross sections were applied for metabolites identification. Following the application of two plant protection products (containing the above-mentioned active compounds) in a greenhouse study plant material was cryo-milled and extracted with water/methanol...
April 1, 2018: Food Chemistry
keyword
keyword
45838
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"