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Secondary ion mass spectrometry

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https://www.readbyqxmd.com/read/28523507/tof-sims-parallel-imaging-ms-ms-of-lipid-species-in-thin-tissue-sections
#1
Anne Lisa Bruinen, Gregory L Fisher, Ron M A Heeren
Unambiguous identification of detected species is essential in complex biomedical samples. To date, there are not many mass spectrometry imaging techniques that can provide both high spatial resolution and identification capabilities. A new and patented imaging tandem mass spectrometer, exploiting the unique characteristics of the nanoTOF II (Physical Electronics, USA) TOF-SIMS TRIFT instrument, was developed to address this.Tandem mass spectrometry is based on the selection of precursor ions from the full secondary ion spectrum (MS(1)), followed by energetic activation and fragmentation, and collection of the fragment ions to obtain a tandem MS spectrum (MS(2))...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28521505/orientation-and-conformation-of-osteocalcin-adsorbed-onto-calcium-phosphate-and-silica-surfaces
#2
Luisa A Scudeller, Selvi Srinivasan, Alexandre M Rossi, Patrick S Stayton, Gary P Drobny, David G Castner
Adsorption isotherms, circular dichroism (CD) spectroscopy, x-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were used to investigate the adsorption of human osteocalcin (hOC) and decarboxylated (i.e., Gla converted back to Glu) hOC (dhOC) onto various calcium phosphate surfaces as well as silica surfaces. The adsorption isotherms and XPS nitrogen signals were used to track the amount of adsorbed hOC and dhOC. The intensities of key ToF-SIMS amino acid fragments were used to assess changes in the structure of adsorbed hOC and dhOC...
May 18, 2017: Biointerphases
https://www.readbyqxmd.com/read/28516281/tof-sims-study-of-differentiation-of-human-bone-derived-stromal-cells-new-insights-into-osteoporosis
#3
Kaija Schaepe, Janina Werner, Kristina Glenske, Tessa Bartges, Anja Henss, Marcus Rohnke, Sabine Wenisch, Jürgen Janek
Lipids have numerous important functions in the human body, as they form the cells' plasma membranes and play a key role in many disease states, presumably also in osteoporosis. Here, the fatty acid composition of the outer plasma membranes of cells differentiated into the osteogenic and adipogenic direction is studied with surface-sensitive time-of-flight secondary ion mass spectrometry (ToF-SIMS). For data evaluation, principal component analysis (PCA) is applied. Human (bone-derived) mesenchymal stromal cells (hMSCs) from an osteoporotic donor and a control donor are compared to reveal differences in the fatty acid composition of the membranes...
May 18, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28508622/correlation-of-interface-impurities-and-chemical-gradients-with-high-magnetoelectric-coupling-strength-in-multiferroic-bifeo3-batio3-superlattices
#4
Michael Lorenz, Dietmar Hirsch, Christian Patzig, Thomas Höche, Stefan Hohenberger, Holger Hochmuth, Vera Lazenka, Kristiaan Temst, Marius Grundmann
The detailed understanding of magnetoelectric (ME) coupling in multiferroic oxide heterostructures is still a challenge. In particular, very little is known to date concerning the impact of the chemical interface structure and unwanted impurities that may be buried within short-period multiferroic BiFeO3-BaTiO3 superlattices during growth. Here, we demonstrate how trace impurities and elemental concentration gradients contribute to high ME voltage coefficients in thin film superlattices which are built from 15 double layers of BiFeO3-BaTiO3...
May 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28508381/visualization-of-metallodrugs-in-single-cells-by-secondary-ion-mass-spectrometry-imaging
#5
REVIEW
Kui Wu, Feifei Jia, Wei Zheng, Qun Luo, Yao Zhao, Fuyi Wang
Secondary ion mass spectrometry, including nanoscale secondary ion mass spectrometry (NanoSIMS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), has emerged as a powerful tool for biological imaging, especially for single cell imaging. SIMS imaging can provide information on subcellular distribution of endogenous and exogenous chemicals, including metallodrugs, from membrane through to cytoplasm and nucleus without labeling, and with high spatial resolution and chemical specificity. In this mini-review, we summarize recent progress in the field of SIMS imaging, particularly in the characterization of the subcellular distribution of metallodrugs...
May 15, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28507244/inhibition-of-staphylococcus-aureus-cell-wall-biosynthesis-by-desleucyl-oritavancin-a-quantitative-peptidoglycan-composition-analysis-by-mass-spectrometry
#6
James D Chang, Erin E Foster, Aanchal N Thadani, Alejandro J Ramirez, Sung Joon Kim
Oritavancin is a lipoglycopeptide antibiotic that exhibits potent activities against vancomycin-resistant Gram-positive pathogens. Oritavancin differs from vancomycin by a hydrophobic side chain attached to the drug disaccharide, which forms a secondary-binding site to enable oritavancin binding to the cross-linked peptidoglycan in cell wall. The mode of action of secondary-binding site was investigated by measuring the changes in the peptidoglycan composition of Staphylococcus aureus grown in presence of desleucyl-oritavancin at sub-inhibitory concentration using liquid chromatography-mass spectrometry (LC-MS)...
May 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28502183/fabrication-microscopic-and-spectroscopic-characterization-of-planar-bimetallic-micro-and-nanopatterned-surfaces
#7
Cristiana Passiu, Antonella Rossi, Laetitia Bernard, Dennis Paul, John S Hammond, Wolfgang E S Unger, Nagaiyanallur V Venkataraman, Nicholas D Spencer
Micropatterns and nanopatterns of gold embedded in silver and titanium embedded in gold have been prepared by combining either photolithography or electron-beam lithography (EBL) with a glue-free template-stripping procedure. The obtained patterned surfaces have been topographically characterized by means of atomic force microscopy (AFM) and scanning electron microscopy (SEM), showing a very low root-mean-square (RMS) roughness (<0.5 nm), high coplanarity between the two metals (maximum height difference ~2 nm) and topographical continuity at the bimetallic interface...
May 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28502172/direct-dopant-patterning-by-remote-monolayer-doping-enabled-by-monolayer-fragmentation-study
#8
Ori Hazut, Roie Yerushalmi
The development of new doping methods extending beyond the traditional and well-established techniques is desired to match the rapid advances made in semiconductor processing methods and nanostructure synthesis in numerous emerging applications, including the doping of 3D architectures. To address this, monolayer doping (MLD) and monolayer contact doping (MLCD) methods were recently introduced. The monolayer doping methods enable separation of the doping process of nanostructures from the synthesis step, hence it is also termed ex-situ doping...
May 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28502168/age-dating-of-individual-micrometer-sized-uranium-particles-by-secondary-ion-mass-spectrometry-an-additional-fingerprint-for-nuclear-safeguards-purposes
#9
Anne-Laure Faure, Thomas Dalger
A direct and simultaneously analysis of the age and isotopic composition of nuclear material at the particle scale is described in this study. By comparison with other conventional techniques such as Inductively Coupled Plasma Mass Spectrometry or Thermal Ionization Mass Spectrometry, Secondary Ion Mass Spectrometry enables to determine individual ages of a mixture of nuclear materials. Having access to the purification date can give precious information on the history of a nuclear facility or nuclear material for Safeguards purposes...
May 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28502161/formation-and-inhibition-of-metallic-lithium-microstructures-in-lithium-batteries-driven-by-chemical-crossover
#10
Wangda Li, Un-Hyuck Kim, Andrei Dolocan, Yang-Kook Sun, Arumugam Manthiram
The formation of metallic lithium microstructures in the form of dendrites or mosses at the surface of anode electrodes (e.g., lithium metal, graphite, and silicon) leads to rapid capacity fade and poses grave safety risks in rechargeable lithium batteries. We present here a direct, relative quantitative analysis of lithium deposition on graphite anodes in pouch cells under normal operating conditions, paired with a model cathode material, the layered nickel-rich oxide LiNi0.61Co0.12Mn0.27O2, over the course of 3000 charge-discharge cycles...
May 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28501859/molecular-insights-into-covalently-stained-carious-dentine-using-solid-state-nmr-and-tof-sims
#11
Ulrica S Almhöjd, Peter Lingström, Åke Nilsson, Jörgen G Norén, Sandra Siljeström, Åsa Östlund, Diana Bernin
Dyes currently used to stain carious dentine have a limited capacity to discriminate normal dentine from carious dentine, which may result in overexcavation. Consequently, finding a selective dye is still a challenge. However, there is evidence that hydrazine-based dyes, via covalent bonds to functional groups, bind specifically to carious dentine. The aim of this study was to investigate the possible formation of covalent bonds between carious dentine and 15N2-hydrazine and the hydrazine-based dye, 15N2-labelled Lucifer Yellow, respectively...
May 13, 2017: Caries Research
https://www.readbyqxmd.com/read/28489027/direct-analyses-of-secondary-metabolites-by-mass-spectrometry-imaging-msi-from-sunflower-helianthus-annuus-l-trichomes
#12
Denise Brentan Silva, Anna-Katharina Aschenbrenner, Norberto Peporine Lopes, Otmar Spring
Helianthus annuus (sunflower) displays non-glandular trichomes (NGT), capitate glandular trichomes (CGT), and linear glandular trichomes (LGT), which reveal different chemical compositions and locations in different plant tissues. With matrix-assisted laser desorption/ionization (MALDI) and laser desorption/ionization (LDI) mass spectrometry imaging (MSI) techniques, efficient methods were developed to analyze the tissue distribution of secondary metabolites (flavonoids and sesquiterpenes) and proteins inside of trichomes...
May 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28488287/design-for-the-transfer-of-a-validated-lc-ms-ms-analytical-method-for-the-determination-of-antimicrobial-residues-in-honey-from-low-resolution-to-high-resolution-mass-spectrometry
#13
Khaled E L Hawari, Mohamad A L Iskandarani, Sophie Mompelat, Dominique Hurtaud-Pessel, Eric Verdon
RATIONALE: This paper investigates the validity of the transfer of a Liquid Chromatography tandem Mass Spectrometry (LC-MS/MS) method for the determination of veterinary medicinal products in honey and compared to an LC- Linear Ion Trap/Orbitrap Mass Spectrometry method. Descriptive statistical approach was performed in order to assess if such transfer may succeed or fail. This approach is based on the simultaneous evaluation of the trueness and of the intermediate precision for each compound at a 95% interval of confidence of both analytical techniques...
May 10, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28487120/surface-anchored-counterions-on-weak-chiral-anion-exchangers-accelerate-separations-and-improve-their-compatibility-for-mass-spectrometry-hyphenation
#14
Ulrich Woiwode, Adrian Sievers-Engler, Aleksandra Zimmermann, Wolfgang Lindner, Orlando L Sánchez-Muñoz, Michael Lämmerhofer
In the present work we propose new variants of chiral stationary phases (CSP) with tert-butylcarbamoylquinine (tBuCQN) as chiral selector molecule. Four tBuCQN-CSPs with distinct bonding chemistries are compared in terms of their pH-dependent surface charge by ζ-potential determinations, by achiral and chiral liquid chromatographic tests and LC-ESI-MS hyphenation. In one embodiment tBuCQN was immobilized on 3-mercaptopropylmethylsilyl-modified silica by thiol-ene click reaction (brush type CSP with selector coverage of 0...
April 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28485953/galvanostatic-rejuvenation-of-electrochromic-wo3-thin-films-ion-trapping-and-detrapping-observed-by-optical-measurements-and-by-time-of-flight-secondary-ion-mass-spectrometry
#15
Bill Baloukas, Miguel A Arvizu, Rui-Tao Wen, Gunnar A Niklasson, Claes G Granqvist, Richard Vernhes, Jolanta E Klemberg-Sapieha, Ludvik Martinu
Electrochromic (EC) smart windows are able to decrease our energy footprint while enhancing indoor comfort and convenience. However, the limited durability of these windows, as well as their cost, result in hampered market introduction. Here, we investigate thin films of the most widely studied EC material, WO3. Specifically, we combine optical measurements (using spectrophotometry in conjunction with variable-angle spectroscopic ellipsometry) with time-of-flight secondary ion mass spectrometry and atomic force microscopy...
May 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28484972/radical-generation-from-the-gas-phase-activation-of-ionized-lipid-ozonides
#16
Shane R Ellis, Huong T Pham, Marc In Het Panhuis, Adam J Trevitt, Todd W Mitchell, Stephen J Blanksby
Reaction products from the ozonolysis of unsaturated lipids at gas-liquid interfaces have the potential to significantly influence the chemical and physical properties of organic aerosols in the atmosphere. In this study, the gas-phase dissociation behavior of lipid secondary ozonides is investigated using ion-trap mass spectrometry. Secondary ozonides were formed by reaction between a thin film of unsaturated lipids (fatty acid methyl esters or phospholipids) with ozone before being transferred to the gas phase as [M + Na](+) ions by electrospray ionization...
May 8, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28481102/reversible-and-irreversible-electric-field-induced-morphological-and-interfacial-transformations-of-hybrid-lead-iodide-perovskites
#17
Sergey Yu Luchkin, Azat F Akbulatov, Lyubov A Frolova, Monroe P Griffin, Andrei Dolocan, Raluca Gearba, David A Vanden Bout, Pavel A Troshin, Keith J Stevenson
We report reversible and irreversible strain effects and interfacial atomic mixing in MAPbI3/ITO under influence of external electric bias and photoillumination. Using conductive-probe atomic force microscopy, we locally applied a bias voltage between the MAPbI3/ITO and the conductive tip and observed local dynamic strain effects and current under conditions of forward bias. We found that the reversible part of the strain is associated with a current spike at the current onset stage and can therefore be related to an electrochemical process accompanied by local molar volume change...
May 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28480907/metabolomic-analysis-of-the-effects-of-cadmium-and-copper-treatment-in-oryza-sativa-l-using-untargeted-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry-and-all-ion-fragmentation
#18
Meritxell Navarro-Reig, Joaquim Jaumot, Benjamín Piña, Encarnación Moyano, Maria Teresa Galceran, Romà Tauler
While the knowledge of plant metabolomes has increased in the last few years, their response to the presence of toxicants is still poorly understood. Here, we analyse the metabolomic changes in Japanese rice (Oryza sativa var. Japonica) upon exposure to heavy metals (Cd(ii) and Cu(ii)) in concentrations from 10 to 1000 μM. After harvesting, rice metabolites were extracted from aerial parts of the plants and analysed by HPLC (HILIC TSK gel amide-80 column) coupled to a mass spectrometer quadrupole-Orbitrap (Q-Exactive)...
May 8, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28480587/melatonin-successfully-rescues-hippocampal-bioenergetics-and-improves-cognitive-function-following-drug-intoxication-by-promoting-nrf2-are-signaling-activity
#19
Li-You Chen, Ting-Yi Renn, Wen-Chieh Liao, Fu-Der Mai, Ying-Jui Ho, George Hsiao, Ai-Wei Lee, Hung-Ming Chang
Prolonged exposure to gamma-hydroxybutyric acid (GHB) would cause drug intoxication in which impaired cognitive function results from enhanced hippocampal oxidative stress may serve as a major symptom in this deficiency. Considering melatonin possesses significant anti-oxidative efficacy, present study aims to determine whether melatonin would successfully promote the Nrf2-ARE signaling, depress oxidative stress, and rescue hippocampal bioenergetics and cognitive function following drug intoxication injury...
May 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28466025/review-of-combined-isotopic-and-optical-nanoscopy
#20
REVIEW
Katharina N Richter, Silvio O Rizzoli, Sebastian Jähne, Angela Vogts, Jelena Lovric
Investigating the detailed substructure of the cell is beyond the ability of conventional optical microscopy. Electron microscopy, therefore, has been the only option for such studies for several decades. The recent implementation of several super-resolution optical microscopy techniques has rendered the investigation of cellular substructure easier and more efficient. Nevertheless, optical microscopy only provides an image of the present structure of the cell, without any information on its long-temporal changes...
April 2017: Neurophotonics
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