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Secondary ion mass spectrometry

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https://www.readbyqxmd.com/read/29351722/evaluation-of-matrix-effects-on-tof-sims-data-of-leu-enkephalin-and-1-2-dioleoyl-sn-glycero-3-phosphocholine-mixed-samples
#1
Shusuke Nakano, Takayuki Yamagishi, Satoka Aoyagi, André Portz, Michael Dürr, Hideo Iwai, Tomoko Kawashima
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is one of the most powerful methods to analyze biomolecules in biological tissues and cells because it provides detailed chemical structure information and chemical images with a high spatial resolution. However, in terms of quantitative analysis, there are issues such as matrix effects that often cause secondary ion intensity changes regardless of the actual concentration in a sample. For instance, the intensity of secondary ions related to peptides is generally suppressed when lipids coexist...
January 19, 2018: Biointerphases
https://www.readbyqxmd.com/read/29350624/conductive-bridge-random-access-memory-characteristics-of-sicn-based-transparent-device-due-to-indium-diffusion
#2
Dayanand Kumar, Rakesh Aluguri, Umesh Chand, Tseung-Yuen Tseng
In this work, the transparent bipolar resistive switching characteristics of SiCN-based ITO/SiCN/AZO structure due to In diffusion from ITO was studied. SiCN based device is found to be 80 % transparent in the visible wavelength region. This device with AZO as both top and bottom electrodes did not show any RRAM property due to deposition of the high quality O2 free SiCN film. Replacing the AZO top electrode with ITO in this device exhibited good resistive switching(RS) characteristics with high on/off ratio and long retention...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29342982/detection-of-zro%C3%A2-nanoparticles-in-lung-tissue-sections-by-time-of-flight-secondary-ion-mass-spectrometry-and-ion-beam-microscopy
#3
Lothar Veith, Julia Böttner, Antje Vennemann, Daniel Breitenstein, Carsten Engelhard, Jan Meijer, Irina Estrela-Lopis, Martin Wiemann, Birgit Hagenhoff
The increasing use of nanoparticles (NP) in commercial products requires elaborated techniques to detect NP in the tissue of exposed organisms. However, due to the low amount of material, the detection and exact localization of NP within tissue sections is demanding. In this respect, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Ion Beam Microscopy (IBM) are promising techniques, because they both offer sub-micron lateral resolutions along with high sensitivities. Here, we compare the performance of the non-material-consumptive IBM and material-consumptive ToF-SIMS for the detection of ZrO₂ NP (primary size 9-10 nm) in rat lung tissue...
January 15, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29336549/top-down-hydrogen-deuterium-exchange-analysis-of-protein-structures-using-ultraviolet-photodissociation-uvpd
#4
Nicholas I Brodie, Romain Huguet, Terry Zhang, Rosa Viner, Vlad Zabrouskov, Jingxi Pan, Evgeniy V Petrotchenko, Christoph H Borchers
Top-down hydrogen-deuterium exchange (HDX) analysis using electron capture or transfer dissociation Fourier transform mass spectrometry is a powerful method for the analysis of secondary structure of proteins in solution. The resolution of the method is a function of the extensive fragmentation of backbone bonds in the proteins. While fragmentation is usually extensive near the N- and C-termini, electron capture (ECD) or electron transfer dissociation (ETD) fragmentation methods sometimes lack good coverage of certain regions of the protein - most often in the middle of the sequence...
January 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29334733/surface-functionalization-with-carboxylic-acids-by-photochemical-microcontact-printing-and-tetrazole-chemistry
#5
Christoph Buten, Sebastian Lamping, Martin Körsgen, Heinrich F Arlinghaus, Craig Jamieson, Bart Jan Ravoo
In this paper we show that carboxylic acid functionalized molecules can be patterned by photochemical microcontact printing on tetrazole-terminated self-assembled monolayers. Upon irradiation, tetrazoles eliminate nitrogen to form highly reactive nitrile imines, which can be ligated with several different nucleophiles, carboxylic acids being most reactive. As a proof of concept, we immobilized trifluoroacetic acid to monitor the reaction with X-ray photoelectron spectroscopy (XPS). Moreover, we also immobilized peptides and fabricated carbohydrate-lectin as well as biotin-streptavidin microarrays using this method...
January 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29331438/characterization-of-surface-properties-of-glass-vials-used-as-primary-packaging-material-for-parenterals
#6
Dominique Ditter, Hanns-Christian Mahler, Holger Roehl, Michael Wahl, Joerg Huwyler, Alejandra Nieto, Andrea Allmendinger
The appropriate selection of adequate primary packaging, such as the glass vial, rubber stopper, and crimp cap for parenteral products is of high importance to ensure product stability, microbiological quality (integrity) during storage as well as patient safety. A number of issues can arise when inadequate vial material is chosen, and sole compliance to hydrolytic class I is sometimes not sufficient when choosing a glass vial. Using an appropriate pre-treatment, such as surface modification or coating of the inner vial surface after the vial forming process the glass container quality is often improved and interactions of the formulation with the surface of glass may be minimized...
January 10, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29329503/chemical-imaging-of-aggressive-basal-cell-carcinoma-using-time-of-flight-secondary-ion-mass-spectrometry
#7
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, Noora Neittaanmäki, John Paoli, John S Fletcher
A set of basal cell carcinoma samples, removed by Mohs micrographic surgery and pathologically identified as having an aggressive subtype, have been analyzed using time-of-flight secondary ion mass spectrometry (SIMS). The SIMS analysis employed a gas cluster ion beam (GCIB) to increase the sensitivity of the technique for the detection of intact lipid species. The GCIB also allowed these intact molecular signals to be maintained while surface contamination and delocalized chemicals were removed from the upper tissue surface...
January 12, 2018: Biointerphases
https://www.readbyqxmd.com/read/29327028/transition-metals-and-trace-elements-in-the-retinal-pigment-epithelium-and-choroid-correlative-ultrastructural-and-chemical-analysis-by-analytical-electron-microscopy-and-nano-secondary-ion-mass-spectrometry
#8
Antje Biesemeier, Oliver Eibl, Santhana Eswara, Jean-Nicolas Audinot, Tom Wirtz, Ulrich Schraermeyer
Understanding the localisation and abundance of structural elements, trace elements and especially transition metals like Cu and Zn in ocular tissue sections is important for physiology, and also for the characterisation of diseases related to oxidative stress like age-related macular degeneration. Transition metal abundances were investigated in an aged donor eye by nano-secondary ion mass spectrometry (nano-SIMS) elemental mapping using Cs+ and O- primary ions, respectively, and correlated to their respective mole fractions investigated by analytical electron microscopy (AEM)...
January 12, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29322127/chemical-tracer-diffusion-of-sr-and-co-in-polycrystalline-ca-deficient-camno3-%C3%AE-with-camn2o4-precipitates
#9
Temesgen D Desissa, Nikola Kanas, Sathya P Singh, Kjell Wiik, Mari-Ann Einarsrud, Truls Norby
Diffusivity on the A- and B-site of polycrystalline perovskite CaMnO3-δ with Ca deficiency and spinel CaMn2O4 (marokite) as a secondary phase was studied using chemical tracers and secondary ion mass spectrometry (SIMS) complemented by electron probe microanalysis (EPMA). Thin films containing Sr and Co chemical tracers were deposited on the polished surface of the polycrystalline composite sample followed by annealing at 800-1200 °C for 96 h. Diffusion profiles for each tracer were determined with SIMS, followed by calculation of diffusion coefficients by fitting to appropriate models...
January 11, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29320860/time-of-flight-secondary-ion-mass-spectrometry-analyses-of-vancomycin
#10
Lin Du, Xiaohui Yang, Wenqiang Li, Haoying Li, Shanbao Feng, Rong Zeng, Bin Yu, Liangxing Xiao, Yu Liu, Mei Tu, Heng-Yong Nie
As an antibiotic that prevents and treats infections caused by Gram-positive bacteria such as Staphylococcus aureus, vancomycin incorporated in a biodegradable polymer poly(lactide-co-glycolide) provides opportunities to construct controlled-release drug delivery systems. Developments associated with this promising system have been largely concentrated on areas of drug delivery kinetics and biodegradability. In order to provide surface analytical approaches to this important system, the authors demonstrate applicability of time-of-flight secondary ion mass spectrometry (TOF-SIMS) in three-dimensional molecular imaging for a model system consisting of alternating layers of ploy(lactide-co-glycolide) and vancomycin...
January 10, 2018: Biointerphases
https://www.readbyqxmd.com/read/29318767/determination-of-synephrine-in-feeds-by-a-novel-quechers-solid-phase-extraction-method-combined-with-uhplc-ms-ms
#11
Yue Song, Tingting Chai, Shengting Lou, Yuechen Zhao, Xining Zhang, Shuming Yang, Yongzhong Qian, Jing Qiu
To detect and quantify synephrine in feed, an effective analytical method based on quick, easy, cheap, effective, rugged and safe solid-phase extraction coupled to ultra high performance liquid chromatography with tandem mass spectrometry was developed with isotopic internal standards. Pretreatment was performed using quick, easy, cheap, effective, rugged and safe solid-phase extraction with primary secondary amine (PSA) and C18 sorbent (C18) as sorbents in combination with Oasis MCX column clean-up to extract and purify feed samples...
January 10, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29317684/deep-level-transient-spectroscopic-investigation-of-phosphorus-doped-silicon-by-self-assembled-molecular-monolayers
#12
Xuejiao Gao, Bin Guan, Abdelmadjid Mesli, Kaixiang Chen, Yaping Dan
It is known that self-assembled molecular monolayer doping technique has the advantages of forming ultra-shallow junctions and introducing minimal defects in semiconductors. In this paper, we report however the formation of carbon-related defects in the molecular monolayer-doped silicon as detected by deep-level transient spectroscopy and low-temperature Hall measurements. The molecular monolayer doping process is performed by modifying silicon substrate with phosphorus-containing molecules and annealing at high temperature...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29313043/breathing-and-oscillating-growth-of-solid-electrolyte-interphase-upon-electrochemical-cycling
#13
Zengqing Zhuo, Peng Lu, Charles Delacourt, Ruimin Qiao, Kang Xu, Feng Pan, Stephen J Harris, Wanli Yang
We report the first direct experimental evidence of the dynamic behavior of the solid-electrolyte-interphase (SEI) on copper electrodes upon electrochemical cycling. Synchrotron-based soft X-ray absorption spectroscopy (sXAS) and time-of-flight secondary ion mass spectrometry (TOF-SIMS) consistently show that both the chemical composition and the thickness of the SEI change with electrochemical potential throughout the slow formation process. In particular, sXAS results show that the nascent carbonate species in SEI show redox reversibility and decompose during the delithiation (oxidation) process, which leads to a significant shrinking of the SEI thickness as confirmed by TOF-SIMS...
January 9, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29295620/high-initial-sputter-rate-found-for-vaccinia-virions-using-isotopic-labeling-nanosims-and-afm
#14
Sean Damien Gates, Richard C Condit, Nissin Moussatche, Benjamin J Stewart, Alexander J Malkin, Peter K Weber
High lateral resolution secondary ion mass spectrometry (SIMS) has the potential to provide functional and depth resolved information from small biological structures, such as viral particles (virions) and phage, but sputter rate and sensitivity are not characterized at shallow depths relevant to these structures. Here we combine stable isotope labeling of the DNA of vaccinia virions with correlated SIMS imaging depth profiling and atomic force microscopy (AFM) to develop a non-linear, non-equilibrium sputter rate model for the virions and validate the model based on reconstructing the location of the DNA within individual virions...
January 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29295614/insights-into-the-maldi-process-after-matrix-deposition-by-sublimation-using-3d-tof-sims-imaging
#15
Sebastiaan Van Nuffel, Nicolas Elie, Ethan Yang, Julius Nouet, David Touboul, Pierre Chaurand, Alain Brunelle
Imaging mass spectrometry (IMS) has become a powerful tool to characterise the spatial distribution of biomolecules in thin tissue sections. In the case of matrix-assisted laser desorption ionisation (MALDI) IMS, homogeneous matrix deposition is critical to produce high quality ion images and sublimation in particular has shown to be an excellent matrix deposition method for the imaging of lipids. Matrix deposition by sublimation is, however, a completely solvent-free system, which ought to prevent the mixing of matrix and analytes thought to be necessary for successful MALDI...
January 3, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29287234/improving-the-discovery-of-secondary-metabolite-natural-products-using-ion-mobility-mass-spectrometry
#16
REVIEW
Alexandra C Schrimpe-Rutledge, Stacy D Sherrod, John A McLean
Secondary metabolite discovery requires an unbiased, comprehensive workflow to detect unknown unknowns for which little to no molecular knowledge exists. Untargeted mass spectrometry-based metabolomics is a powerful platform, particularly when coupled with ion mobility for high-throughput gas-phase separations to increase peak capacity and obtain gas-phase structural information. Ion mobility data are described by the amount of time an ion spends in the drift cell, which is directly related to an ion's collision cross section (CCS)...
December 26, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29286544/direct-analysis-by-time-of-flight-secondary-ion-mass-spectrometry-tof-sims-reveals-action-of-bacterial-laccase-mediator-system-on-both-hardwood-and-softwood-samples
#17
Robyn E Goacher, Erick J Braham, Courtney L Michienzi, Robert M Flick, Alexander F Yakunin, Emma R Master
The modification and degradation of lignin play a vital role in carbon cycling as well as production of biofuels and bioproducts. The possibility of using bacterial laccases for the oxidation of lignin offers a route to utilize existing industrial protein expression techniques. However, bacterial laccases are most frequently studied on small model compounds that do not capture the complexity of lignocellulosic materials. This work studied the action of laccases from Bacillus subtilis and Salmonella typhimurium (EC 1...
December 29, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29276427/quantitative-imaging-of-deuterated-metabolic-tracers-in-biological-tissues-with-nanoscale-secondary-ion-mass-spectrometry
#18
Christelle Guillermier, J Collin Poczatek, Walter R Taylor, Matthew L Steinhauser
In the field of secondary ion mass spectrometry at nanometer scale (NanoSIMS), configuration of parallel detectors to routinely measure isotope ratios in sub-100 nm domains brings classical stable isotope tracer studies from the whole tissue level down to the suborganelle level. Over the past decade, the marriage of stable isotope tracers with NanoSIMS has been applied to a range of fundamental biological questions that were largely inaccessible by other means. Although multiplexed measurement of different stable isotope tracers is feasible, in practice there remains a gap in the current analytical capacity to efficiently measure stable isotopes commonly utilized in tracer studies...
November 2017: International Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29260555/investigation-of-silver-nanoparticle-induced-lipids-changes-on-single-cell-surface-by-tof-sims
#19
Xin Hua, Hao-Wen Li, Yi-Tao Long
Lipids are the main component of cell membrane. They not only provide structural support of cells, but also directly partici-pate in complex cellular metabolic processes. Lipid signaling is an important part of cell signaling. Evidence showed that ab-normal cellular metabolism may induce lipids changes. Besides, owing to single cell heterogeneity, it is necessary to distinguish different behaviors of individual cells. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a sensitive surface analy-sis technique with high spatial resolution, which is useful in single cell surface analysis...
December 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29248344/use-of-an-online-extraction-liquid-chromatography-quadrupole-time-of-flight-tandem-mass-spectrometry-method-for-the-characterization-of-polyphenols-in-citrus-paradisi-cv-changshanhuyu-peel
#20
Chaoying Tong, Mijun Peng, Runna Tong, Ruyi Ma, Keke Guo, Shuyun Shi
Chemical profiling of natural products by high performance liquid chromatography (HPLC) was critical for understanding of their clinical bioactivities, and sample pretreatment steps have been considered as a bottleneck for analysis. Currently, concerted efforts have been made to develop sample pretreatment methods with high efficiency, low solvent and time consumptions. Here, a simple and efficient online extraction (OLE) strategy coupled with HPLC-diode array detector-quadrupole time-of-flight tandem mass spectrometry (HPLC-DAD-QTOF-MS/MS) was developed for rapid chemical profiling...
December 12, 2017: Journal of Chromatography. A
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