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https://www.readbyqxmd.com/read/29656137/haploidentical-peripheral-blood-stem-cell-transplantation-demonstrates-stable-engraftment-in-adults-with-sickle-cell-disease
#1
Santosh L Saraf, Annie L Oh, Pritesh R Patel, Karen Sweiss, Matthew Koshy, Sally Campbell-Lee, Michel Gowhari, Shivi Jain, David Peace, John G Quigley, Irum Khan, Robert E Molokie, Nadim Mahmud, Victor R Gordeuk, Damiano Rondelli
We report on the screening and development of haploidentical hematopoietic stem cell transplantation (HSCT) for adult patients with clinically aggressive sickle cell disease (SCD) at our institution. Of 50 adult SCD patients referred for HSCT between 1/2014-3/2017, 20% were denied by insurance. Of 41 patients initially screened, 10% lacked an available haploidentical donor, 29% had elevated donor specific antibodies (DSA) and 34% declined to proceed to HSCT. All 10 patients who were transplanted received peripheral blood stem cells (PBSC)...
April 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29652619/circulating-cytokine-chemokine-concentrations-respond-to-ionizing-radiation-doses-but-not-radiation-dose-rates-granulocyte-colony-stimulating-factor-and-interleukin-18
#2
Juliann G Kiang, Joan T Smith, Sara R Hegge, Natalia I Ossetrova
Exposure to ionizing radiation is a crucial life-threatening factor in nuclear and radiological incidents. It is known that ionizing radiation affects cytokine/chemokine concentrations in the blood of B6D2F1 mice. It is not clear whether radiation dose rates would vary the physiological response. Therefore, in this study we utilized data from two experiments using B6D2F1 female mice exposed to six different dose rates ranging from low to high rates. In one experiment, mice received a total dose of 8 Gy (LD0/30 ) of 60 Co gamma radiation at four dose rates: 0...
April 13, 2018: Radiation Research
https://www.readbyqxmd.com/read/29652549/prolonged-granulocyte-colony-stimulating-factor-use-in-glycogen-storage-disease-type-1b-associated-with-acute-myeloid-leukemia-and-with-shortened-telomere-length
#3
Amanda M Li, Santhosh Thyagu, Dawn Maze, Richard Schreiber, Sandra Sirrs, Sylvia Stockler-Ipsiroglu, Heather Sutherland, Suzanne Vercauteren, Kirk R Schultz
Glycogen storage disease (GSD) type 1 is a rare autosomal recessive inherited condition. The 1b subtype comprises the minority of cases, with an estimated prevalence of 1 in 500,000 children. Patients with glycogen storage disease type 1b are often treated with granulocyte colony stimulating factor (G-CSF) for prolonged periods to improve symptoms of inflammatory bowel disease (IBD) and in the face of severe neutropenia to decrease risk of infection. Long-term G-CSF treatment may result in an increased risk of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) possibly due to increased marrow stress resulting in telomere shortening...
April 13, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29651017/effects-of-different-doses-of-granulocyte-colony-stimulating-factor-mobilization-therapy-on-ischemic-cardiomyopathy
#4
Rongchong Huang, Haichen Lv, Kang Yao, Lei Ge, Zhishuai Ye, Huaiyu Ding, Yiqi Zhang, Hao Lu, Zheyong Huang, Shuning Zhang, Yunzeng Zou, Junbo Ge
G-CSF mobilization might be beneficial to ICM, but the relationship between effect/safety and the dosage of G-CSF remains unclear. In this study, 24 pigs were used to build ICM models and were randomized into four groups. Four weeks later, different dosages of G-CSF were given daily by subcutaneous injection for 5 days. Another 4 weeks later, all the animals were sacrificed. Electrocardiography, coronary arteriography, left ventriculography, transthoracic echocardiography, cardiac MRI, and SPECT, histopathologic analysis, and immunohistochemistry techniques were used to evaluate left ventricular function and myocardial infarct size...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643956/serum-cytokines-in-early-prediction-of-anastomotic-leakage-following-low-anterior-resection
#5
Marek Zawadzki, Małgorzata Krzystek-Korpacka, Andrzej Gamian, Wojciech Witkiewicz
Introduction: Anastomotic leakage continues to be one of the most serious complications following low anterior resections. Early diagnosis of a leak is difficult but critical to minimize morbidity and mortality. Aim: To evaluate changes in serum concentrations of 27 different cytokines following low anterior resection, with the goal of finding new, early biomarkers of anastomotic leak. Material and methods: This is a prospective observational study that includes 32 patients undergoing elective low anterior resection for rectal cancer...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29642403/cebpd-is-essential-for-gamma-tocotrienol-mediated-protection-against-radiation-induced-hematopoietic-and-intestinal-injury
#6
Sudip Banerjee, Sumit K Shah, Stepan B Melnyk, Rupak Pathak, Martin Hauer-Jensen, Snehalata A Pawar
Gamma-tocotrienol (GT3) confers protection against ionizing radiation (IR)-induced injury. However, the molecular targets that underlie the protective functions of GT3 are not yet known. We have reported that mice lacking CCAAT enhancer binding protein delta ( Cebpd-/- ) display increased mortality to IR due to injury to the hematopoietic and intestinal tissues and that Cebpd protects from IR-induced oxidative stress and cell death. The purpose of this study was to investigate whether Cebpd mediates the radio protective functions of GT3...
April 6, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29628925/human-endothelial-cells-modulate-cd4-t-cell-populations-and-enhance-regulatory-t-cell-suppressive-capacity
#7
Wen Chean Lim, Michael Olding, Eugene Healy, Timothy M Millar
Endothelial cells (ECs) line the luminal surface of blood vessels and have an active role in the recruitment of leukocytes, including immune cell activation. Regulatory T cells (Tregs) are immune suppressor cells that maintain peripheral tolerance and must interact with the endothelium as they traffic into tissue. We hypothesized that human ECs could modulate Tregs and their suppressor function. Cocultures of CD4+ T cells with human umbilical vein ECs (HUVECs) or dermal microvascular ECs (HDMECs) were conducted and analyzed for activation and proliferation after 72 and 120 h using flow cytometry...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29626667/the-effects-of-il-1%C3%AE-il-8-g-csf-and-tnf-%C3%AE-as-molecular-adjuvant-on-the-immune-response-to-an-e-tarda-subunit-vaccine-in-flounder-paralichthys-olivaceus
#8
Ming Guo, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
Cytokines play vital roles in mounting immune responses and activating host defense network. In this study, the expression plasmid pcDNA3.1 (pcN3) encoding four flounder (Paralichthys olivaceus) cytokines including IL-1β, TNF-α, IL-8 or G-CSF (pcIL-1β, pcTNF-α, pcIL-8 and pcG-CSF) were successfully constructed, and their adjuvant potential on an Edwardsiella tarda (E. tarda) subunit vaccine OmpV (rOmpV) were comparatively analyzed in vaccinated flounder model. Results revealed that flounder vaccinated with rOmpV plus pcIL-1β, pcIL-8 or pcG-CSF produced the relative percent survivals (RPS) of 71%, 65% and 49% respectively, which were higher than that in flounder vaccinated with rOmpV plus pcTNF-α (39%) or pcN3 (36%, the control group)...
April 5, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29616871/dcep-as-a-bridge-to-ongoing-therapies-for-advanced-relapsed-and-or-refractory-multiple-myeloma
#9
Hiu Lam Agnes Yuen, Michael Sze Yuan Low, Pasquale Fedele, Anna Kalff, Patricia Walker, Krystal Bergin, John Coutsouvelis, George Grigoriadis, Andrew Spencer
There is limited data describing dexamethasone, cyclophosphamide, etoposide, and cisplatin (DCEP) in relapsed refractory multiple myeloma (RRMM). We reviewed 65 patients with RRMM receiving DCEP between 2005 and 2017 in two Melbourne Hospitals. Patients had received a mean of three prior treatment lines (range, 1-11). The mean number of cycles of DCEP was two (range, 1-4). Overall response rate (ORR) was 55% whilst 19% achieved MR and SD. Median overall survival (OS) was 9.6 months. Those bridged to autologous stem cell transplant (ASCT) had significantly improved OS compared to those who were not (median 32...
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29616840/decitabine-in-combination-with-g-csf-low-dose-cytarabine-and-aclarubicin-is-as-effective-as-standard-dose-chemotherapy-in-the-induction-treatment-for-patients-aged-from-55-to-69-years-old-with-newly-diagnosed-acute-myeloid-leukemia
#10
Jiayu Huang, Ming Hong, Yu Zhu, Huihui Zhao, Xiaoyan Zhang, Yujie Wu, Yun Lian, Xiaoli Zhao, Jianyong Li, Sixuan Qian
We retrospectively studied 87 patients aged from 55 to 69 years old with acute myeloid leukemia (AML) who received decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin (DCAG) or standard dose chemotherapy as induction therapy. Patients receiving DCAG had a similar overall response rate (ORR) (p = .6105) and complete remission (CR) rate (p = .3615) compared to those undergoing standard induction. The median overall survival (OS) and relapse-free survival (RFS) was also similar between the two groups although more 'older' (aged from 60 to 69 years old) and 'unfit' patients underwent DCAG regimen...
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29605509/the-effects-of-lower-cd34-yields-after-lowe-dose-g-csf-induction-on-long-term-autologous-stem-cell-transplantation-outcome-a-single-center-study
#11
Mohammad Vaezi, Mohammad Shakouri, Maryam Souri, Mohammad Amin Setaredan, Seyed Asadollah Mossavi, Saeed Mohammadi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Peripheral blood stem cell transplantation (PBSCT) is an effective treatment for hematological malignancies. Mobilization of peripheral blood stem cells performs in different ways among transplantation centers. Since the Effects of lower CD34+ cells dose after low dose G-CSF induction on autologous stem cell transplantation outcomes are not studied much, so this study was performed for this purpose. 735 autologous stem cell transplanted patients with diagnoses of multiple myeloma (n = 330), Hodgkin lymphoma (n = 200), non-Hodgkin lymphoma (n = 129), acute myeloid leukemia (n = 54) and solid tumors (n = 22) were retrospectively evaluated...
March 23, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29604263/cerebrospinal-fluid-%C3%AE-synuclein-contributes-to-the-differential-diagnosis-of-alzheimer-s-disease
#12
Min Shi, Lu Tang, Jon B Toledo, Carmen Ginghina, Hua Wang, Patrick Aro, Poul H Jensen, Daniel Weintraub, Alice S Chen-Plotkin, David J Irwin, Murray Grossman, Leo McCluskey, Lauren B Elman, David A Wolk, Edward B Lee, Leslie M Shaw, John Q Trojanowski, Jing Zhang
INTRODUCTION: The ability of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers (amyloid β peptide 1-42, total tau, and phosphorylated tau) to discriminate AD from related disorders is limited. Biomarkers for other concomitant pathologies (e.g., CSF α-synuclein [α-syn] for Lewy body pathology) may be needed to further improve the differential diagnosis. METHODS: CSF total α-syn, phosphorylated α-syn Ser129, and AD CSF biomarkers were evaluated with Luminex immunoassays in 367 participants, followed by validation in 74 different neuropathologically confirmed cases...
March 28, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29603795/optia%C3%A2-continuous-mononuclear-collection-cmnc-system-is-a-safe-and-efficient-system-for-hematopoietic-progenitor-cells-apheresis-hpc-a-collection-and-yields-a-lower-product-hematocrit-hct-than-the-cobe%C3%A2-spectra-system-a-retrospective-study
#13
Soumya Pandey, Michele Cottler-Fox
PURPOSE: We evaluated the Optia® continuous mononuclear collection (CMNC) system for hematopoietic progenitor cell-apheresis (HPC-A) collection (Terumo BCT, Lakewood, CO) compared to the COBE® Spectra (Terumo BCT, Lakewood, CO), including both large volume leukapheresis (LVL) and non-LVL collections. METHODS: We performed a retrospective data analysis of all autologous HPC-A collections with the Optia® CMNC system (n = 93; LVL = 59, non-LVL = 34) since implementation at our institution and compared it with a similar number of concurrent collections utilizing the COBE® Spectra (n = 96; LVL = 68, non-LVL = 28)...
March 30, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29600976/impact-of-endostatin-gene-therapy-on-myeloid-derived-suppressor-cells-from-a-metastatic-renal-cell-carcinoma
#14
K C Chaves, E M Costa, L F Teixeira, M H Bellini
AIM: To evaluate the role of endostatin (ES) gene therapy on myeloid-derived suppressor cells (MDSC) in a metastatic model of renal cell carcinoma (RCC). MATERIALS AND METHODS: Balb/C mice bearing orthotopic Renca tumors were treated with NIH/3T3-LendSN or, as a control, with NIH/3T3-LXSN cells. At the end of in vivo experiment, plasma and tissue lung samples were collected. Plasma ES and granulocyte colony stimulating factor (G-CSF) levels were measured by ELISA and Milliplex, respectively...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29594877/granulocyte-colony-stimulating-factor-producing-lung-cancer-with-severe-anemia-of-inflammation
#15
Koutaro Murakami, Yujin Kudo, Masatoshi Kakihana, Jun Matsubayashi, Tetsuya Okano, Yoshihisa Shimada, Toshitaka Nagao, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
Granulocyte colony stimulating factor (G-CSF)-producing lung cancer occasionally induces severe inflammation with an abnormally high white blood cell count. Herein, we report a 49-year-old man who suffered from resectable G-CSF-producing non-small cell lung cancer with continuous fever and severe anemia. Red blood cell transfusion was necessary for the anemia of inflammation. The patient underwent complete surgical tumor resection. The histopathological diagnosis was a pleomorphic carcinoma at pathological stage IIB...
March 28, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29590407/costs-associated-with-febrile-neutropenia-in-japanese-patients-with-primary-breast-cancer-post-hoc-analysis-of-a-randomized-clinical-trial
#16
Osamu Miyake, Kyoko Murata, Shiro Tanaka, Hiroshi Ishiguro, Masakazu Toi, Kazuo Tamura, Koji Kawakami
Background: Febrile neutropenia (FN), a decrease in blood neutrophils accompanied by fever, is a major adverse event (AE) associated with cancer chemotherapy. We aimed to estimate the direct medical costs associated with FN management in breast cancer patients within a clinical trial with pegfilgrastim, a pegylated form of recombinant granulocyte colony-stimulating factor (G-CSF). Methods: We obtained data from 346 Japanese breast cancer patients in a randomized, placebo-controlled clinical trial comparing FN incidence due to TC adjuvant chemotherapy (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2) between pegfilgrastim-treated and placebo groups...
March 26, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29576502/the-healthy-donor-profile-of-immunoregulatory-soluble-mediators-is-altered-by-stem-cell-mobilization-and-apheresis
#17
Guro Kristin Melve, Elisabeth Ersvaer, Kristin Paulsen Rye, Aymen Bushra Ahmed, Einar K Kristoffersen, Tor Hervig, Håkon Reikvam, Kimberley Joanne Hatfield, Øystein Bruserud
BACKGROUND: Peripheral blood stem cells from healthy donors mobilized by granulocyte colony-stimulating factor (G-CSF) and thereafter harvested by leukapheresis are commonly used for allogeneic stem cell transplantation. METHODS: Plasma levels of 38 soluble mediators (cytokines, soluble adhesion molecules, proteases, protease inhibitors) were analyzed in samples derived from healthy stem cell donors before G-CSF treatment and after 4 days, both immediately before and after leukapheresis...
March 22, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29575692/effect-of-the-in-vivo-application-of-granulocyte-colony-stimulating-factor-on-nk-cells-in-bone-marrow-and-peripheral-blood
#18
Xing-Xing Yu, Ting-Ting Han, Ling-Ling Xu, Ying-Jun Chang, Xiao-Jun Huang, Xiang-Yu Zhao
Granulocyte colony-stimulating factor (G-CSF) has been widely used in the field of allogeneic haematopoietic stem cell transplantation (allo-HSCT) for priming donor stem cells from the bone marrow (BM) to peripheral blood (PB) to collect stem cells more conveniently. Donor-derived natural killer (NK) cells have important antitumour functions and immune regulatory roles post-allo-HSCT. The aim of this study was to evaluate the effect of G-CSF on donors' NK cells in BM and PB. The percentage of NK cells among nuclear cells and lymphocyte was significantly decreased and led to increased ratio of T and NK cells in BM and PB post-G-CSF in vivo application...
March 25, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29572761/efficacy-of-weekly-administration-of-paclitaxel-and-carboplatin-for-advanced-ovarian-cancer-patients-with-poor-performance-status
#19
Hisamitsu Takaya, Hidekatsu Nakai, Kosuke Murakami, Takako Tobiume, Ayako Suzuki, Masaki Mandai, Noriomi Matsumura
OBJECTIVE: The aim of this study was to reveal the efficacy of weekly administration of paclitaxel and carboplatin for advanced ovarian cancer patients with poor performance status (PS). METHODS: FIGO stage III/IV ovarian cancer or fallopian tube cancer patients who underwent interval debulking surgery (IDS) followed by neoadjuvant chemotherapy (NAC) were analyzed retrospectively. Patients were divided into two groups based on NAC: weekly paclitaxel and carboplatin (W-TC) and 3 weeks of paclitaxel and carboplatin (TW-TC)...
March 23, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29572702/depleted-polymorphonuclear-leukocytes-in-human-metastatic-liver-reflect-an-altered-immune-microenvironment-associated-with-recurrent-metastasis
#20
Fiona Hand, Cathal Harmon, Louise A Elliott, Francesco Caiazza, Aonghus Lavelle, Donal Maguire, Emir Hoti, Niamh Nolan, Justin G Geoghegan, Elizabeth J Ryan, Cliona O'Farrelly
BACKGROUND: Hepatic immunity, normally protective against neoplasia, is subverted in colorectal liver metastasis (CRLM). Here, we compare the inflammatory microenvironment of CRLM-bearing liver tissue to donor liver. METHODS: Twenty-five patients undergoing resection for CRLM were recruited, 13 of whom developed intrahepatic recurrence within 18 months. Biopsies were obtained from tumour and normal liver tissue adjacent to and distal from, the tumour. Donor liver biopsies were obtained during transplantation...
March 23, 2018: Cancer Immunology, Immunotherapy: CII
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