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https://www.readbyqxmd.com/read/29306077/the-e3-ubiquitin-ligase-hectd1-is-involved-in-abca1-mediated-cholesterol-export-from-macrophages
#1
Shereen M Aleidi, Alryel Yang, Laura J Sharpe, Geetha Rao, Blake J Cochran, Kerry-Anne Rye, Maaike Kockx, Andrew J Brown, Ingrid C Gelissen
The ABC lipid transporters, ABCA1 and ABCG1, are essential for maintaining lipid homeostasis in cells such as macrophages by exporting excess cholesterol to extracellular acceptors. These transporters are highly regulated at the post-translational level, including protein ubiquitination. Our aim was to investigate the role of the E3 ubiquitin ligase HECTD1, recently identified as associated with ABCG1, on ABCG1 and ABCA1 protein levels and cholesterol export function. Here, we show that HECTD1 protein is widely expressed in a range of human and murine primary cells and cell lines, including macrophages, neuronal cells and insulin secreting β-cells...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29298513/andrographolide-inhibits-oxidized-ldl-induced-cholesterol-accumulation-and-foam-cell-formation-in-macrophages
#2
Hung-Chih Lin, Chong-Kuei Lii, Hui-Chun Chen, Ai-Hsuan Lin, Ya-Chen Yang, Haw-Wen Chen
oxLDL is involved in the pathogenesis of atherosclerotic lesions through cholesterol accumulation in macrophage foam cells. Andrographolide, the bioactive component of Andrographis paniculata, possesses several biological activities such as anti-inflammatory, anti-oxidant, and anticancer functions. Scavenger receptors (SRs), including class A SR (SR-A) and CD36, are responsible for the internalization of oxLDL. In contrast, receptors for reverse cholesterol transport, including ABCA1 and ABCG1, mediate the efflux of cholesterol from macrophage foam cells...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29290792/therapeutic-effects-of-targeted-ppar%C3%A9-activation-on-inflamed-high-risk-plaques-assessed-by-serial-optical-imaging-in-vivo
#3
Jah Yeon Choi, Jiheun Ryu, Hyun Jung Kim, Joon Woo Song, Joo Hee Jeon, Dae-Hee Lee, Dong Joo Oh, Dae-Gab Gweon, Wang-Yuhl Oh, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Rationale: Atherosclerotic plaque is a chronic inflammatory disorder involving lipid accumulation within arterial walls. In particular, macrophages mediate plaque progression and rupture. While PPARγ agonist is known to have favorable pleiotropic effects on atherogenesis, its clinical application has been very limited due to undesirable systemic effects. We hypothesized that the specific delivery of a PPARγ agonist to inflamed plaques could reduce plaque burden and inflammation without systemic adverse effects...
2018: Theranostics
https://www.readbyqxmd.com/read/29284608/melanocortin-1-receptor-deficiency-promotes-atherosclerosis-in-apolipoprotein-e-mice
#4
Petteri Rinne, James J Kadiri, Mauricio Velasco-Delgado, Salla Nuutinen, Miro Viitala, Maija Hollmén, Martina Rami, Eriika Savontaus, Sabine Steffens
OBJECTIVE: The MC1-R (melanocortin 1 receptor) is expressed by monocytes and macrophages where it mediates anti-inflammatory actions. MC1-R also protects against macrophage foam cell formation primarily by promoting cholesterol efflux through the ABCA1 (ATP-binding cassette transporter subfamily A member 1) and ABCG1 (ATP-binding cassette transporter subfamily G member 1). In this study, we aimed to investigate whether global deficiency in MC1-R signaling affects the development of atherosclerosis...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29281244/high-density-lipoprotein-nanobiologics-for-precision-medicine
#5
Willem J M Mulder, Mandy M T van Leent, Marnix Lameijer, Edward A Fisher, Zahi A Fayad, Carlos Pérez-Medina
Nature is an inspirational source for biomedical engineering developments. Particularly, numerous nanotechnological approaches have been derived from biological concepts. For example, among many different biological nanosized materials, viruses have been extensively studied and utilized, while exosome research has gained much traction in the 21st century. In our body, fat is transported by lipoproteins, intriguing supramolecular nanostructures that have important roles in cell function, lipid metabolism, and disease...
December 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29259301/global-inactivation-of-carboxylesterase-1-ces1-ces1g-protects-against-atherosclerosis-in-ldlr-mice
#6
Jiesi Xu, Yang Xu, Yanyong Xu, Liya Yin, Yanqiao Zhang
Atherosclerotic cardiovascular disease is a leading cause of death in the western world. Increased plasma triglyceride and cholesterol levels are major risk factors for this disease. Carboxylesterase 1 (Ces1/Ces1g) has been shown to play a role in metabolic control. So far, the role of mouse Ces1/Ces1g deficiency in atherosclerosis is not elucidated. We generated Ces1/Ces1g -/- mice. Compared to wild-type mice, Ces1/Ces1g -/- mice had reduced plasma cholesterol levels. We then generated Ces1g -/- Ldlr -/- double knockout (DKO) mice, which were fed a Western diet for 16 weeks...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242172/curcumin-enhances-lxr%C3%AE-in-an-amp-activated-protein-kinase-dependent-manner-in-human-macrophages
#7
Javier Sáenz, Gonzalo Alba, María E Reyes-Quiroz, Isabel Geniz, Juan Jiménez, Francisco Sobrino, Consuelo Santa-María
Liver X receptor alpha (LXRα) is a nuclear receptor involved in cholesterol homeostasis. Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa and a well-known AMP-activated protein kinase (AMPK) activator, possess hypocholesterolemic activity, however, the possible link between AMPK and cholesterol is unknown. In this study, we have investigated whether curcumin regulates metabolic changes in cholesterol metabolism via LXRα in THP-1 human macrophages, the cells implicated in atheroma plaques formation...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29234690/the-dataset-describes-phenotypic-changes-induced-by-cholesterol-loading-in-smooth-muscle-cells-isolated-from-the-aortae-of-c57bl-6-mice
#8
Silvia Castiglioni, Matteo Monti, Giuditta Ainis Buscherini, Lorenzo Arnaboldi, Monica Canavesi, Alberto Corsini, Stefano Bellosta
The data presented in this article is related to the research article entitled "ABCA1 and HDL3 are Required to Modulate Smooth Muscle Cells Phenotypic Switch after Cholesterol Loading" (Castiglioni et al., 2017) [1]. This data describes the characterization of the phenotypic changes induced by cholesterol loading in smooth muscle cells (SMCs) isolated from the aortae of C57BL/6 mice. Upon cholesterol loading, there is a significant and concentration-dependent decrease in the expression of Acta2 and a parallel increase in Mac-2, and ATP binding cassette (ABC) transporters Abca1 and Abcg1...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29226138/effects-of-astaxanthin-on-reverse-cholesterol-transport-and-atherosclerosis-in-mice
#9
Tang-Bin Zou, Shan-Shan Zhu, Fei Luo, Wei-Qiao Li, Xue-Rong Sun, Hong-Fu Wu
High plasma level of HDL-cholesterol (HDL-C) has been consistently associated with a decreased risk of atherosclerosis (AS); thus, HDL-C is considered to be an antiatherogenic lipoprotein. The development of novel therapies to enhance the atheroprotective properties of HDL may have the possibility of further reducing the residual AS risk. Reverse cholesterol transport (RCT) is believed to be a primary atheroprotective activity of HDL, which has been shown to promote the efflux of excess cholesterol from macrophage-derived foam cells via ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SR-BI) and then transport it back to the liver for excretion into bile and eventually into the feces...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29199477/phenylpropanoid-glucosides-from-tadehagi-triquetrum-inhibit-oxldl-evoked-foam-cell-formation-through-modulating-cholesterol-homeostasis-in-raw264-7-macrophages
#10
Shuai Wang, Xiaopo Zhang, Xin Li, Qibing Liu, Yue Zhou, Peng Guo, Zhengqi Dong, Chongming Wu
The phenylpropanoid glucosides from Tadehagi triquetrum were found to be beneficial to glucose and lipid metabolism in vitro. Herein, we investigated the effects of these compounds on oxidised low-density lipoprotein (oxLDL)-induced foam cell formation in RAW264.7 macrophages, aiming to evaluate their potential utility in prevention of atherosclerosis. Our results showed that three out of seven phenylpropanoid glucosides significantly inhibited oxLDL-evoked foam cell formation. These three compounds remarkably inhibited cholesterol influx and enhanced cholesterol efflux...
December 4, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29185836/exome-chip-meta-analysis-identifies-association-between-variation-in-ankrd26-and-platelet-aggregation
#11
Ming-Huei Chen, Lisa R Yanek, Joshua D Backman, John D Eicher, Jennifer E Huffman, Yoav Ben-Shlomo, Andrew D Beswick, Laura M Yerges-Armstrong, Alan R Shuldiner, Jeffrey R O'Connell, Rasika A Mathias, Diane M Becker, Lewis C Becker, Joshua P Lewis, Andrew D Johnson, Nauder Faraday
Previous genome-wide association studies (GWAS) have identified several variants associated with platelet function phenotypes; however, the proportion of variance explained by the identified variants is mostly small. Rare coding variants, particularly those with high potential for impact on protein structure/function, may have substantial impact on phenotype but are difficult to detect by GWAS. The main purpose of this study was to identify low frequency or rare variants associated with platelet function using genotype data from the Illumina HumanExome Bead Chip...
November 29, 2017: Platelets
https://www.readbyqxmd.com/read/29172034/development-of-mannose-functionalized-dendrimeric-nanoparticles-for-targeted-delivery-to-macrophages-use-of-this-platform-to-modulate-atherosclerosis
#12
Hongliang He, Quan Yuan, Jinghua Bie, Ryan L Wallace, Paul J Yannie, Jing Wang, Michael G Lancina, Olga Yu Zolotarskaya, William Korzun, Hu Yang, Shobha Ghosh
Dysfunctional macrophages underlie the development of several diseases including atherosclerosis where accumulation of cholesteryl esters and persistent inflammation are 2 of the critical macrophage processes that regulate the progression as well as stability of atherosclerotic plaques. Ligand-dependent activation of liver-x-receptor (LXR) not only enhances mobilization of stored cholesteryl ester but also exerts anti-inflammatory effects mediated via trans-repression of proinflammatory transcription factor nuclear factor kappa B...
November 21, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29164275/dna-methylation-markers-associated-with-type-2-diabetes-fasting-glucose-and-hba1c-levels-a-systematic-review-and-replication-in-a-case-control-sample-of-the-lifelines-study
#13
Eliza Walaszczyk, Mirjam Luijten, Annemieke M W Spijkerman, Marc J Bonder, Helen L Lutgers, Harold Snieder, Bruce H R Wolffenbuttel, Jana V van Vliet-Ostaptchouk
AIMS/HYPOTHESIS: Epigenetic mechanisms may play an important role in the aetiology of type 2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1c levels. Here we present a systematic review of these studies and attempt to replicate the CpG sites (CpGs) with the most significant associations from these EWASs in a case-control sample of the Lifelines study. METHODS: We performed a systematic literature search in PubMed and EMBASE for EWASs to test the association between DNA methylation and type 2 diabetes and/or glycaemic traits and reviewed the search results...
November 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/29140707/grapefruit-flavonoid-naringenin-regulates-the-expression-of-lxr%C3%AE-in-thp-1-macrophages-by-modulating-amp-activated-protein-kinase
#14
Javier Saenz, Consuelo Santa-María, Maria Edith Reyes-Quiroz, Isabel Geniz, Juan Jiménez, Francisco Sobrino, Gonzalo Alba
The present work investigates the modulation of grapefruit flavonoid naringenin over Liver X Receptor alpha (LXRα) and its target genes in THP-1 macrophages, focusing on AMP-activated protein kinase (AMPK) implication. Naringenin induced LXRα at mRNA and protein levels besides influencing the expression of LXRα target genes ABCA1, ABCG1 (ATP-binding cassette A1 and G1), and SREBP1c (sterol response element binding protein 1c) in THP-1 macrophages. The increased LXRα mRNA and protein expression was reverted when AMPK was inhibited by its chemical inhibitor, compound C or by transfection with AMPK α1 and α2 siRNA...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29137283/c1q-tumor-necrosis-factor-related-protein-3-protects-macrophages-against-lps-induced-lipid-accumulation-inflammation-and-phenotype-transition-via-ppar%C3%AE-and-tlr4-mediated-pathways
#15
Jiale Lin, Qi Liu, Hui Zhang, Xingtao Huang, Ruoxi Zhang, Shuyuan Chen, Xuedong Wang, Bo Yu, Jingbo Hou
Macrophage inflammation and foam cell formation are critical events during the initiation and development of atherosclerosis (AS). C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with anti-inflammatory and cardioprotection properties; however, little is known regarding the influence of CTRP3 on AS. As macrophages play a key role in AS, this study investigated the effects of CTRP3 on macrophage lipid metabolism, inflammatory reactions, and phenotype transition, as well as underlying mechanisms, to reveal the relationship between CTRP3 and AS...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29132227/oxidative-stress-in-hiv-infection-and-alcohol-use-role-of-redox-signals-in-modulation-of-lipid-rafts-and-abc-transporters
#16
Samikkannu Thangavel, Carmen T Mulet, Venkata S R Atluri, Marisela Agudelo, Rhonda Rosenberg, Jessy G Devieux, Madhavan P N Nair
AIMS: HIV infection induces oxidative stress and alcohol use accelerates disease progression subsequently causing immune dysfunction. However, HIV and alcohol impact on lipid rafts-mediated immune dysfunction remains unknown. In this study, we investigate the modulation by which oxidative stress induces reactive oxygen species (ROS) affecting redox expression, lipid rafts caveiloin-1, ATP-binding cassette (ABC)-transporters, and transcriptional SREBP gene and protein modification and how these mechanisms are associated with arachidonic acid (AA) metabolites in HIV positive alcohol users, and how they escalate immune dysfunction...
November 13, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29113088/oxidative-stress-in-cardiovascular-diseases-involvement-of-nrf2-antioxidant-redox-signaling-in-macrophage-foam-cells-formation
#17
REVIEW
Bee Kee Ooi, Bey Hing Goh, Wei Hsum Yap
Oxidative stress is an important risk factor contributing to the pathogenesis of cardiovascular diseases. Oxidative stress that results from excessive reactive oxygen species (ROS) production accounts for impaired endothelial function, a process which promotes atherosclerotic lesion or fatty streaks formation (foam cells). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in cellular redox homeostasis. Upon exposure to oxidative stress, Nrf2 is dissociated from its inhibitor Keap-1 and translocated into the nucleus, where it results in the transcriptional activation of cell defense genes...
November 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29069761/myeloid-specific-genetic-ablation-of-atp-binding-cassette-transporter-abca1-is-protective-against-cancer
#18
Maryam Zamanian-Daryoush, Daniel J Lindner, Joseph A DiDonato, Matthew Wagner, Jennifer Buffa, Patricia Rayman, John S Parks, Marit Westerterp, Alan R Tall, Stanley L Hazen
Increased circulating levels of apolipoprotein A-I (apoA-I), the major protein of high-density lipoprotein (HDL), by genetic manipulation or infusion, protects against melanoma growth and metastasis. Herein, we explored potential roles in melanoma tumorigenesis for host scavenger receptor class B, type 1 (SR-B1), and ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1), all mediators of apoA-I and HDL sterol and lipid transport function. In a syngeneic murine melanoma tumor model, B16F10, mice with global deletion of SR-B1 expression exhibited increased plasma HDL cholesterol (HDLc) levels and decreased tumor volume, indicating host SR-B1 does not directly contribute to HDL-associated anti-tumor activity...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045950/leonurine-prevents-atherosclerosis-via-promoting-the-expression-of-abca1-and-abcg1-in-a-ppar%C3%AE-lxr%C3%AE-signaling-pathway-dependent-manner
#19
Ting Jiang, Kun Ren, Qian Chen, Heng Li, Rong Yao, Hu Hu, Yun-Cheng Lv, Guo-Jun Zhao
BACKGROUND/AIMS: Previous studies have demonstrated that leonurine, a unique alkaloid compound of Herba leonuri, can exert anti-oxidative and anti-inflammatory effects on the development of atherosclerosis (AS). This study was designed to investigate the effects of leonurine on cholesterol efflux from THP-1 macrophage-derived foam cells and development of atherosclerotic lesions in apoE-/- mice, and further determine the potential mechanisms. METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL)...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28984832/the-role-of-omega-3-fatty-acids-in-reverse-cholesterol-transport-a-review
#20
REVIEW
Alex Pizzini, Lukas Lunger, Egon Demetz, Richard Hilbe, Guenter Weiss, Christoph Ebenbichler, Ivan Tancevski
The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular disease have been studied extensively. However, it remains unclear to what extent n-3 PUFAs may impact Reverse Cholesterol Transport (RCT). RCT describes a mechanism by which excess cholesterol from peripheral tissues is transported to the liver for hepatobiliary excretion, thereby inhibiting foam cell formation and the development of atherosclerosis. The aim of this review is to summarize the literature and to provide an updated overview of the effects of n-3 PUFAs on key players in RCT, including apoliprotein AI (apoA-I), ATP-binding cassette transporter A1 (ABCA1), ABCG1, apoE, scavenger receptor class B type I (SR-BI), cholesteryl ester transfer protein (CETP), low-density lipoprotein receptor (LDLr), cholesterol 7 alpha-hydroxylase (CYP7A1) and ABCG5/G8...
October 6, 2017: Nutrients
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