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https://www.readbyqxmd.com/read/29668137/costo-efectividad-de-dos-esquemas-de-prevenci%C3%A3-n-de-la-infecci%C3%A3-n-por-citomegalovirus-en-pacientes-con-trasplante-renal-y-riesgo-intermedio-en-colombia
#1
Kateir Contreras, María José Vargas, Paola García, Camilo A González, Patricia Rodríguez, Camilo Castañeda-Cardona, Margarita Otálora-Esteban, Diego Rosselli
Introducción. El citomegalovirus es la causa más frecuente de infección en pacientes con trasplante renal. Existen dos estrategias de similar efectividad para prevenirlo: la profilaxis universal con valganciclovir durante 90 días o el tratamiento anticipado verificando la carga viral semanal y aplicándolo solo si esta es positiva.Objetivo. Determinar cuál de estas dos estrategias sería más costo-efectiva en pacientes de riesgo intermedio en Colombia.Materiales y métodos. Se diseñó un árbol de decisiones bajo la perspectiva del tercer pagador considerando únicamente los costos médicos directos en pesos colombianos (COP) del 2014 durante un periodo de un año en una población de pacientes con riesgo intermedio para citomegalovirus (donante positivo y receptor positivo, o donante negativo y receptor positivo)...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667928/skin-cells-prefer-a-slower-calcium-pump
#2
Seth L Robia, Howard S Young
Naturally occurring mutations of a calcium ion transporter can cause a skin condition known as Darier's disease. In this issue of JBC, Mikkelsen et al. describe a particularly interesting Darier's mutation that alters calcium transport by disrupting a kinetic braking mechanism that is unique to the SERCA2b calcium pump isoform. The study provides new insight into the intrinsic regulation of this transporter and reveals how disruption of regulation can lead to disease in Darier's patients.
March 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29667736/commentary-advancing-an-implementation-science-agenda-on-mental-health-and-psychosocial-responses-in-war-affected-settings-comment-on-trials-of-a-psychosocial-intervention-for-youth-affected-by-the-syrian-crisis-by-panter-brick-et-al-2018
#3
Theresa S Betancourt, Mina Fazel
Syria's civil conflict has created the largest humanitarian disaster of our time, causing massive population displacement, tremendous exposure to trauma, and loss. Advancing the mental health and psychosocial responses of war-affected populations both during acute humanitarian emergencies and in post-conflict transition is imperative in forging a constructive implementation agenda. This study makes an important contribution in building evidence toward effective interventions to advance the mental health and well-being of those affected by the Syrian crisis...
May 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29667659/correction-copper-mediated-regioselective-c-h-etherification-of-naphthylamides-with-arylboronic-acids-using-water-as-an-oxygen-source
#4
Subhasish Roy, Sourav Pradhan, Tharmalingam Punniyamurthy
Correction for 'Copper-mediated regioselective C-H etherification of naphthylamides with arylboronic acids using water as an oxygen source' by Subhasish Roy et al., Chem. Commun., 2018, DOI: 10.1039/c8cc02158a.
April 18, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29667654/re-calvarial-tuberculosis-in-a-preschool-aged-child-an-uncommon-entity
#5
COMMENT
Mahmood D Al-Mendalawi
No abstract text is available yet for this article.
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29667601/probing-ionization-potential-electron-affinity-and-self-energy-effect-on-the-spectral-shape-and-exciton-binding-energy-of-quantum-liquid-water-with-self-consistent-many-body-perturbation-theory-and-bethe-salpeter-equation
#6
Vafa Ziaei, Thomas Bredow
An accurate theoretical prediction of ionization potential (IP) and electron
 affinity (EA) is key for understanding of complex photochemical processes in
 aqueous environments. There have been numerous efforts in literature to
 accurately predict IP and EA of liquid water, however with often
 conflicting results depending on the level of theory and the underlying water
 structures. In a recent study based on hybrid-non-self-consistent many-body
 perturbation theory (MBPT)
 Gaiduk et al...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667564/the-recency-ratio-as-predictor-of-early-mci
#7
Davide Bruno, Rebecca L Koscik, John L Woodard, Nunzio Pomara, Sterling C Johnson
ABSTRACTObjectives:Individuals with Alzheimer's disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. (Journal of Clinical and Experimental Neuropsychology, Vol. 38, 2016, pp. 967-973) have shown that higher ratio scores between immediate and delayed recency (i.e. the recency ratio; Rr) are associated with cognitive decline in high-functioning older individuals. We tested whether Rr predicted conversion to early mild cognitive impairment (early MCI) from a cognitively healthy baseline...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667558/ga-68-nanoparticles-and-ultra-small-nanoparticle-next-generation-of-pet-radiopharmaceuticals
#8
Mohammed Al-Qahtani, Yousif Al Malki, Hadeel Mutwali, Edward Helal-Neto, Ralph Santos-Oliveira
BACKGROUND AND OBJECTIVE: The future of medicine relies on the capability to forecast the future and in the development of new drugs. The same rationale is applied to radiopharmacy. In this direction the development of nano-radiopharmaceuticals represents the most effective glance of the future. METHODS: In this manuscript we developed an efficient, rapid and direct methodology to label ultra-small polymeric nanoparticle (10 to 12 nm) and regular polymeric nanoparticles (200 to 210 nm), both obtained by double emulsion technique, with Ga-68 in order to promote the development of PET-nanoradiopharmaceuticals...
April 17, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29667439/what-is-the-impact-of-the-2017-cochrane-systematic-review-and-meta-analysis-that-evaluated-the-use-of-pcsk9-inhibitors-for-lowering-cardiovascular-disease-and-mortality
#9
Mohamed A Jalloh, Eric J Ip, Shadi Doroudgar
In 2017, Schmidt et al. conducted a Cochrane systematic review and meta-analysis to evaluate the effect of using proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors to reduce low-density-lipoprotein- cholesterol (LDL-C) and cardiovascular disease (CVD). The Cochrane review was a systematic review and meta-analysis of 20 randomized, double-blinded trials that compared the use of PCSK9 inhibitors with statins/ezetimibe, ezetimibe, or placebo for a treatment duration of at least 24 weeks. The use of PCSK9 inhibitors lowered the risk for CVD (OR 0...
April 18, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29667256/procalcitonin-and-c-reactive-protein-as-biomarkers-for-neonatal-bacterial-infection
#10
Ashfaque F Quadir, Philip N Britton
AIM: Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C-reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667246/the-role-of-patients-families-in-treatment-decision-making-among-adult-cancer-patients-in-the-sultanate-of-oman
#11
A Al-Bahri, M Al-Moundhri, Z Al-Mandhari, M Al-Azri
There are limited numbers of studies available in Middle Eastern Arabic countries regarding participation of family ‎members in cancer treatment decision-making (TDM). The aim of this study was to evaluate the role of family members' ‎in TDM among ‎adult Omani cancer ‎patients. A cross-sectional study was conducted in two main teaching hospitals. All adult Omani patients who were diagnosed with cancer and their nominated family members were invited to ‎participate. A tool developed by Cancer Care Outcomes Research and ‎Surveillance Consortium was used to identify the level of family involvement in TDM...
April 17, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29667152/falls-in-mexican-older-adults-aged-60-years-and-older
#12
Luis M Valderrama-Hinds, Soham Al Snih, Nai-Wei Chen, Martin A Rodriguez, Rebeca Wong
BACKGROUND: Falls are a major cause of disability, morbidity, institutionalization, and mortality in older adults. OBJECTIVES: The purpose of the study was to examine the risk factors for falls among Mexican older adults aged 60 years and older. METHODS: This study included 6247 participants and their spouse or partner aged 60 years and older from the Mexican Health and Aging Study, an ongoing longitudinal study (2001-2012) conducted in Mexico...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667087/capsule-commentary-on-dalal-et-al-the-impact-of-automated-notification-on-follow-up-of-actionable-tests-pending-at-discharge-a-cluster-randomized-controlled-trial
#13
Sarah A Stella
No abstract text is available yet for this article.
April 17, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29667060/fate-of-lu-iii-sorbed-on-2-line-ferrihydrite-at-ph-5-7-and-aged-for-12-years-at-room-temperature-ii-insights-from-stem-edxs-and-dft-calculations
#14
Tadahiro Yokosawa, Eric Prestat, Robert Polly, Muriel Bouby, Kathy Dardenne, Nicolas Finck, Sarah J Haigh, Melissa A Denecke, Horst Geckeis
Transformation products of two-line ferrihydrite associated with Lu(III) were studied after 12 years of aging using aberration-corrected high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM), high-efficiency energy-dispersive X-ray spectroscopy (EDXS), and density functional theory (DFT). The transformation products consisted of hematite nanoparticles with overgrown goethite needles. High-efficiency STEM-EDXS revealed that Lu is only associated with goethite needles, and atomic-resolution HAADF-STEM reveals structural incorporation of Lu within goethite, partially replacing structural Fe sites...
April 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29667033/tri11-tri3-and-tri4-genes-are-required-for-trichodermin-biosynthesis-of-trichoderma-brevicompactum
#15
Xuping Shentu, Jiayi Yao, Xiaofeng Yuan, Linmao He, Fan Sun, Kozo Ochi, Xiaoping Yu
Trichoderma brevicompactum and T. arundinaceum both can synthesize trichodermin with strong antifungal activity and high biotechnological value. The two Trichoderma species have a tri cluster, which includes seven genes (tri14, tri12, tri11, tri10, tri3, tri4, and tri6) that encode transport and regulatory enzymes required for the biosynthesis of trichodermin. Here, we isolated T. brevicompactum 0248 transformants with disrupted tri11, tri4, or tri3 gene. We also described the effect of tri11, tri3, or tri4 deletion on the expression of other genes in the tri cluster...
April 17, 2018: AMB Express
https://www.readbyqxmd.com/read/29666901/subcutaneously-administered-dexmedetomidine-is-efficiently-absorbed-and-is-associated-with-attenuated-cardiovascular-effects-in-healthy-volunteers
#16
P Uusalo, D Al-Ramahi, I Tilli, R A Aantaa, M Scheinin, T I Saari
PURPOSE: Palliative care patients often need sedation to alleviate intractable anxiety, stress, and pain. Dexmedetomidine is used for sedation of intensive care patients, but there is no prior information on its subcutaneous (SC) administration, a route that would be favored in palliative care. We compared the pharmacokinetics and cardiovascular, sympatholytic, and sedative effects of SC and intravenously (IV) administered dexmedetomidine in healthy volunteers. METHODS: An open two-period, cross-over design with balanced randomization was used...
April 17, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29666850/expression-of-concern-zno-nanoparticles-affect-intestinal-function-in-an-in-vitro-model
#17
Philippa Hughes
Expression of concern for 'ZnO nanoparticles affect intestinal function in an in vitro model' by Fabiola Moreno-Olivas et al., Food Funct., 2018, 9, 1475-1491.
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29666715/identification-of-hollow-viscus-injury-with-fast-examination-in-kurdistan-iraq
#18
Ruj Al-Sindy, Heleen Alaqrawy, Mahmood Sh Hafdullah, Christine Butts
Point-of-care ultrasound has become indispensable in the evaluation of trauma, particularly in low resource areas, where it may be the only rapidly available imaging modality. The FAST (Focused Assessment with Sonography in Trauma) in particular can be lifesaving, by rapidly detecting signs of intra-abdominal hemorrhage. However, the FAST is primarily designed to identify free fluid associated with solid organ injury and is thought to have less sensitivity and power in identifying evidence of hollow viscus injury...
2018: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/29666692/a-rare-case-of-rectovaginal-fistula-due-to-consensual-sexual-intercourse
#19
Fida Al-Asali, Rami Kilani, Firas Rshoud, Ismaiel A Mahfouz
Rectovaginal fistulae after sexual intercourse are rare. We report a healthy recently married 21-year-old woman who presented to the Jordan Healthcare Centre, Amman, Jordan in 2014 with a five-week history of passing flatus and stool from the vagina. Six weeks prior, she had sustained a rectovaginal injury during initial consensual sexual intercourse, leading to the development of a distal rectovaginal fistula . A successful transvaginal repair was performed nine weeks after presentation which resulted in the complete resolution of her symptoms...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29666684/item-analysis-of-multiple-choice-questions-at-the-department-of-paediatrics-arabian-gulf-university-manama-bahrain
#20
Deena Kheyami, Ahmed Jaradat, Tareq Al-Shibani, Fuad A Ali
Objectives: The current study aimed to carry out a post-validation item analysis of multiple choice questions (MCQs) in medical examinations in order to evaluate correlations between item difficulty, item discrimination and distraction effectiveness so as to determine whether questions should be included, modified or discarded. In addition, the optimal number of options per MCQ was analysed. Methods: This cross-sectional study was performed in the Department of Paediatrics, Arabian Gulf University, Manama, Bahrain...
February 2018: Sultan Qaboos University Medical Journal
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