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Allyson D Page, Lauren Siegel, Mandar Jog
Purpose: In this preliminary study, we examined self-rated communication-related quality of life (CR-QoL) of 10 control participants and 10 individuals with oromandibular dystonia (OMD) and dysarthria receiving therapeutic botulinum toxin (BoNT-A) injections. Method: Participants with OMD and associated dysarthria self-rated CR-QoL pre- and post- BoNT-A injection using the American Speech-Language-Hearing Association's Quality of Communication Life Scale (ASHA QCL; Paul et al...
June 22, 2017: American Journal of Speech-language Pathology
Liu Leo Liu, Levy L Cao, Yue Shao, Douglas W Stephan
Single electron transfer (SET) reactions are effected by the combination of a Lewis acid (e.g. E(C6F5)3 E = B or Al) with a small molecule substrate and decamethylferrocene (Cp*2Fe). Initially, the corresponding reactions of (PhS)2 and (PhTe)2 were shown to give the species [Cp*2Fe][PhSB(C6F5)3] 1 and [Cp*2Fe][(-PhS)(Al(C6F5)3)2] 2 and [Cp*2Fe][(-PhTe)(Al(C6F5)3)2] 3, respectively. Analogous reactions with di-tert-butyl peroxide yielded [Cp*2Fe][(-HO)(B(C6F5)3)2] 4 with isobutene while with benzoyl peroxide afforded [Cp*2Fe][PhC(O)OE(C6F5)3] (E = B 5, Al 6)...
June 27, 2017: Journal of the American Chemical Society
Dajiang Wang, Behzad Amoozgar, Travis Porco, Zhen Wang, Shan C Lin
PURPOSE: To investigate whether differences exist in lens position and other lens parameters among major ethnic groups with cataractous eyes, which may help explain racial differences in angle closure risk. METHODS: This retrospective, cross-sectional study included 807 adult patients who had cataract surgery between years 2014 and 2016 at the University of California, San Francisco (UCSF). Adult patients of white, Asian, Hispanic and African-American ethnicity were included...
2017: PloS One
Philip A Gruppuso, Eli Y Adashi
No abstract text is available yet for this article.
July 2017: Academic Medicine: Journal of the Association of American Medical Colleges
(no author information available yet)
No abstract text is available yet for this article.
July 2017: American Journal on Intellectual and Developmental Disabilities
Sukhbinder Dhesy-Thind, Glenn G Fletcher, Mark Clemons, Catherine Van Poznak
No abstract text is available yet for this article.
June 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Yuanda Liu, Kah-Wee Ang
Two-dimensional (2D) inverter is a fundamental building block for flexible logic circuit which has previously been realized by heterogeneously wiring transistors with two discrete channel materials. Here, we demonstrate a monolithically integrated complementary inverter made using a homogenous black phosphorus (BP) nanosheet on flexible substrates. The digital logic inverter circuit is demonstrated via effective threshold voltage tuning within a single BP material, which offers both electron and hole dominated conducting channels with nearly symmetric pinch-off and current saturation...
June 27, 2017: ACS Nano
Someswara Rao Kosuru, Ting-Han Sun, Li-Fang Wang, Jaya Kishore Vandavasi, Wei-Yi Lu, Yi-Chun Lai, Sodio C N Hsu, Michael Y Chiang, Hsuan-Ying Chen
A series of dinuclear aluminum (Al2Pyr2) complexes bridged by two pyrazole ligands were synthesized, and their catalytic activity toward ring-opening polymerization of ε-caprolactone (CL) was investigated. Different types of the Al-N-N-Al-N-N skeletal ring were found among these Al2Pyr2 complexes. The butterfly form, L(Thio)2Al2Me4, exerted the highest catalytic activity for CL polymerization. κ(2)-CL coordination with both Al centers within the butterfly form L(Thio)2Al2Me4 facilitates the initiation process...
June 27, 2017: Inorganic Chemistry
J M Smits
In the 8th century AD, under the reign of the Abbasid caliph Harun al-Rashid, the House of Wisdom was inaugurated in Baghdad.(1) This was a center of learning and transmission of classical wisdom, where scholars from all parts of the world gathered to learn and to transmit all the world's knowledge. So it is an ancient, albeit brilliant, concept to bring together all the beautiful minds and by exchanging and confronting opinions and ideas, gain new knowledge. This article is protected by copyright. All rights reserved...
June 27, 2017: American Journal of Transplantation
Abd El-Galil E Amr, Mohamed A Al-Omar, Mohamed M Abdalla
In this work, twenty-one thiopyrimidine (1-21) candidates containing a pyrane, pyrazoline and thiazolopyrimidine ring screened for their ED50 and 5α-reductase inhibitors comparable to that of Anastrozole as positive drug. Some of the tested product showed moderate 5α-reductase inhibitors with lower toxicity. The detailed ED50 and 5α-reductase inhibitor activities of the synthesized compounds were studied.
May 2017: Pakistan Journal of Pharmaceutical Sciences
Anselm W Hahn, Benjamin E Van Kuiken, Mustafa Al Samarai, Mihail Atanasov, Thomas Weyhermüller, Yi-Tao Cui, Jun Miyawaki, Yoshihisa Harada, Alessandro Nicolaou, Serena DeBeer
Ligand field spectra provide direct information about the electronic structure of transition metal complexes. However, these spectra are difficult to measure by conventional optical techniques due to small cross sections for d-to-d transitions and instrumental limitations below 4000 cm(-1). 2p3d resonant inelastic X-ray scattering (RIXS) is a second order process that utilizes dipole allowed 2p to 3d transitions to access d-d excited states. The measurement of ligand field excitation spectra by RIXS is demonstrated for a series of tetrahedral and octahedral Fe(II) and Fe(III) chlorides, which are denoted Fe(III)-Td, Fe(II)-Td, Fe(III)-Oh, and Fe(II)-Oh...
June 27, 2017: Inorganic Chemistry
Al-Mahmnur Alam, KyungNae Baek, Jieun Son, Yi-Rong Pei, Dong Ha Kim, Jin-Ho Choy, Jerome Kartham Hyun
Single particle Mie calculations of near micron-sized TiO2 particles predict strong light scattering dominating the visible range that would give rise to a white appearance. We demonstrate that a polydisperse collection of these 'white' particles can result in the generation of visible colors through ensemble scattering. The weighted averaging of the scattering over the particle size distribution modifies the sharp, multiple, high order scattering modes from individual particles into broad variations in the collective extinction...
June 27, 2017: ACS Applied Materials & Interfaces
Mohammad M Al-Ahmad, Naheed Amir, Subramanian Dhanasekaran, Anne John, Yousef M Abdulrazzaq, Bassam R Ali, Salim Bastaki
BACKGROUND AND PURPOSE: Individuals with slow N-acetylation phenotype often experience toxicity from drugs such as isoniazid, sulfonamides, procainamide, and hydralazine, whereas rapid acetylators may not respond to these medications. The highly polymorphic N-acetyltransferase 2 enzyme encoded by the NAT2 gene is one of the N-acetylators in humans with a clear impact on the metabolism of a significant number of important drugs. However, there are limited studies on N-acetylation phenotypes and NAT2 genotypes among Emiratis, and thus this study was carried out to fill this gap...
June 27, 2017: Annals of Human Genetics
F Bibi, I Ullah, S A Alvi, S A Bakhsh, M Yasir, A A K Al-Ghamdi, E I Azhar
Marine bacteria have been exceptional sources of halotolerant enzymes since decades. The aim of the present study was to isolate bacteria producing hydrolytic enzymes from seven different mangroves collected from the coastal area of Thuwal, Jeddah, Saudi Arabia, and to further screen them for other enzymatic and antifungal activities. We have isolated 46 different rhizo- and endophytic bacteria from the soil, roots, and leaves of the mangroves using different enzymatic media. These bacterial strains were capable of producing industrially important enzymes (cellulase, protease, lipase, and amylase)...
June 20, 2017: Genetics and Molecular Research: GMR
Dalia M Abdel Basset, Suresh Mulmi, Mohammed S El-Bana, Suzan S Fouad, Venkataraman Thangadurai
Correction for 'Synthesis and characterization of novel Li-stuffed garnet-like Li5+2xLa3Ta2-xGdxO12 (0 ≤ x ≤ 0.55): structure-property relationships' by Dalia M. Abdel Basset, et al., Dalton Trans., 2017, 46, 933-946.
June 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Megan Reed Showalter, Jason Hatakeyama, Tomas Cajka, Kacey VanderVorst, Kermit L Carraway, Oliver Fiehn
In 2016, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Fiehn et al., 2016), that described how we intended to replicate selected experiments from the paper "The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate" (Ward et al., 2010). Here, we report the results of those experiments. We found that cells expressing R172K mutant IDH2 did not display isocitrate-dependent NADPH production above vector control levels, in contrast to the increased production observed with wild-type IDH2...
June 27, 2017: ELife
Xiaochuan Shan, Juan Jose Fung, Alan Kosaka, Gwenn Danet-Desnoyers
In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Fung et al., 2015), that described how we intended to replicate selected experiments from the paper "Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia" (Dawson et al., 2011). Here, we report the results of those experiments. We found treatment of MLL-fusion leukaemia cells (MV4;11 cell line) with the BET bromodomain inhibitor I-BET151 resulted in selective growth inhibition, whereas treatment of leukaemia cells harboring a different oncogenic driver (K-562 cell line) did not result in selective growth inhibition; this is similar to the findings reported in the original study (Figure 2A and Supplementary Figure 11A,B; Dawson et al...
June 27, 2017: ELife
Kristijan Posavec, Marco Giacopetti, Marco Materazzi, Steffen Birk
A new method was developed and implemented into an Excel Visual Basic for Applications (VBAs) algorithm utilizing trigonometry laws in an innovative way to overlap recession segments of time series and create master recession curves (MRCs). Based on a trigonometry approach, the algorithm horizontally translates succeeding recession segments of time series, placing their vertex, that is, the highest recorded value of each recession segment, directly onto the appropriate connection line defined by measurement points of a preceding recession segment...
June 26, 2017: Ground Water
Abdelhakim Salem, Rabeia Almahmoudi, Dyah Listyarifah, Maria Siponen, Katariina Maaninka, Ahmed Al-Samadi, Tuula Salo, Kari K Eklund
PURPOSE: Recent reports indicate that histamine and its novel, high-affinity histamine H4 receptor (H4R) play a role in carcinogenesis, and thus H4R signalling has become a focus of increasing interest in the pathogenesis of many cancers. The roles of H4R in oral epithelial dysplasia (OED) and oral tongue squamous cell carcinoma (OTSCC) are unknown. The purpose of this study was to assess H4R expression in OTSCC patients and in OTSCC-derived cell lines. METHODS: Biopsies taken from OED, OTSCC and healthy oral mucosa were studied by immunostaining...
June 26, 2017: Cellular Oncology (Dordrecht)
Dalal M Al-Taweel, Mohammad Alsuwaidan
Background The goal of evidence-based clinical practice has led to an increased interest in the development of tools to measure adherence to national guidelines in different diseases. This aids in detecting and measuring inappropriate prescribing to specific patient groups by using quality standards extracted from evidence-based guidelines, and ultimately provide the basis of consistent standardized prescribing. Objective To design and validate a medication assessment tool to assess prescribers' adherence to international guideline recommendations in the management of bipolar disorder (MATBD)...
June 26, 2017: International Journal of Clinical Pharmacy
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