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ABCA1

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https://www.readbyqxmd.com/read/29787963/sirt1-activator-e1231-protects-from-experimental-atherosclerosis-and-lowers-plasma-cholesterol-and-triglycerides-by-enhancing-abca1-expression
#1
Tingting Feng, Peng Liu, Xiao Wang, Jinque Luo, Xuan Zuo, Xinhai Jiang, Chang Liu, Yongzhen Li, Ni Li, Minghua Chen, Ningyu Zhu, Xiaowan Han, Chao Liu, Yanni Xu, Shuyi Si
BACKGROUND AND AIMS: Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent protein deacetylase. Recent studies have demonstrated that enhancing SIRT1 expression or activity may modulate cholesterol and lipid metabolism. However, pharmacological and molecular regulators for SIRT1 are scarce. Here, we aimed to find novel small molecule modulators of SIRT1 to regulate cholesterol and lipid metabolism. METHODS: A high-throughput screening assay was established to identify SIRT1 activators...
April 30, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29778664/gestational-diabetes-mellitus-modulates-cholesterol-homeostasis-in-human-fetoplacental-endothelium
#2
Yidan Sun, Susanne Kopp, Jasmin Strutz, Chaitanya Chakravarthi Gali, Martina Zandl-Lang, Elham Fanaee-Danesh, Andrijana Kirsch, Silvija Cvitic, Saša Frank, Richard Saffery, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck
Gestational diabetes mellitus (GDM) is associated with excessive oxidative stress which may affect placental vascular function. Cholesterol homeostasis is crucial for maintaining fetoplacental endothelial function. We aimed to investigate whether and how GDM affects cholesterol metabolism in human fetoplacental endothelial cells (HPEC). HPEC were isolated from fetal term placental arterial vessels of GDM or control subjects. Cellular reactive oxygen species (ROS) were detected by H2 DCFDA fluorescent dye. Oxysterols were quantified by gas chromatography-mass spectrometry analysis...
May 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29777060/protease-activated-receptor-1-inhibits-cholesterol-efflux-and-promotes-atherogenesis-via-cullin-3-mediated-degradation-of-the-abca1-transporter
#3
Somasundaram Raghavan, Nikhlesh K Singh, Arul M Mani, Gadiparthi N Rao
Although signaling of thrombin via its receptor protease-activated receptor 1 (Par1) is known to occur in atherothrombosis, its link to the actual pathogenesis of this condition is less clear. To better understand the role of thrombin-Par1 signaling in atherosclerosis, here we have studied their effects on cellular cholesterol efflux in mice. We found that by activating Par1 and cullin 3-mediated ubiquitination and degradation of ATP-binding cassette subfamily A member 1 (ABCA1), thrombin inhibits cholesterol efflux in both murine macrophages and smooth muscle cells...
May 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29775222/abca1-inhibits-pdgf-induced-proliferation-and-migration-of-rat-airway-smooth-muscle-cell-through-blocking-tlr2-nf-%C3%AE%C2%BAb-nfatc1-signaling
#4
Wei Cheng, Kun Yan, Yanni Chen, Wen Zhang, Zongzheng Ji, Chengxue Dang
Airway remodeling is a key feature of asthma, characterized by abnormal proliferation and migration of airway smooth muscle cells (ASMCs). ABCA1, a member of the ATP-binding cassette family of active transporters, plays an essential role in the progression of lung diseases. However, the contributions of ABCA1 in ASMCs remain to be explored. The purpose of the present study was to investigate the functional role and potential molecular mechanism of ABCA1 in platelet derived growth factor (PDGF)-induced primary rat ASMC proliferation and migration...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29774529/inhibition-of-prmt3-activity-selectively-impairs-lxr-driven-transcription-of-hepatic-lipogenic-genes-in-vivo
#5
Joya E Nahon, Christianne Groeneveldt, Janine J Geerling, Miranda Van Eck, Menno Hoekstra
BACKGROUND AND PURPOSE: Agonists for the liver X receptor (LXR) are considered promising therapeutic moieties in cholesterol-driven diseases by promoting cellular cholesterol efflux pathways. However, current clinical application of these agents is hampered by the concomitant LXR-induced activation of a lipogenic transcriptional network, leading to hepatic steatosis. Recent studies have suggested that protein arginine methyltransferase 3 (PRMT3) may act as a selective co-activator of LXR activity...
May 18, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29773422/a-novel-homozygous-abca1-variant-in-an-asymptomatic-man-with-profound-hypoalphalipoproteinemia
#6
Yaser Carcora, Robert D Brook, Linda Farhat, Cristen J Willer, Melvyn Rubenfire, Daniel Seung Kim
Low high-density lipoprotein cholesterol (HDL-C) can be caused by several acquired secondary causes as well as primary genetic disorders. However, only a few conditions are associated with profoundly reduced levels below 10 mg/dL. We present an unusual case of a healthy man with severely decreased HDL-C because of a novel homozygous variant causing a Proline > Arginine amino acid change at position 1312 in the ATP-binding cassette transporter A1 gene. Homozygous variations in ATP-binding cassette transporter A1 typically cause Tangier disease, a rare autosomal recessive condition linked with several other abnormalities (eg, enlarged discolored tonsils)...
April 21, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29772548/epigenetic-regulation-of-genes-involved-in-the-reverse-cholesterol-transport-through-interaction-with-mirnas
#7
Mohamed Zaiou, Bertrand Henri Rihn, Ahmed Bakillah
microRNAs (miRNAs) are a group of small non-coding RNA molecules known to regulate target genes at the post-transcriptional level. miRNAs are implicated in the regulation of multiple pathophysiological processes including dyslipidemia, a major risk factor for atherosclerosis. Emerging evidence suggests that miRNAs act as a novel class of epigenetic regulators of high-density lipoproteins cholesterol (HDL-C) from synthesis to clearance contributing remarkably to the pathogenesis of atherosclerosis. Accumulating studies have revealed that miRNAs such as miR-33, miR-27, miR-144, miR-758 and miR-20 are involved in the post-transcriptional control of ABCA1, ABCG1 and SCARB1 genes regulatory network of the reverse cholesterol transport (RCT)...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29758034/interactions-among-genes-involved-in-reverse-cholesterol-transport-and-in-the-response-to-environmental-factors-in-dyslipidemia-in-subjects-from-the-xinjiang-rural-area
#8
Xinping Wang, Heng Guo, Yu Li, Haixia Wang, Jia He, Lati Mu, Yunhua Hu, Jiaolong Ma, Yizhong Yan, Shugang Li, Yusong Ding, Mei Zhang, Qiang Niu, Jiaming Liu, Jingyu Zhang, Rulin Ma, Shuxia Guo
Gene-gene and gene-environment interactions may be partially responsible for dyslipidemia, but studies investigating interactions in the reverse cholesterol transport system (RCT) are limited. We explored these interactions in a Xinjiang rural population by genotyping five SNPs using SNPShot technique in APOA1, ABCA1, and LCAT, which are involved in the RCT (690 patients, 743 controls). We conducted unconditional logistical regression analysis to evaluate associations and generalized multifactor dimensionality reduction to evaluate interactions...
2018: PloS One
https://www.readbyqxmd.com/read/29751497/epigenetic-regulation-of-atp-binding-cassette-protein-a1-abca1-gene-expression-a-new-era-to-alleviate-atherosclerotic-cardiovascular-disease
#9
Mohamed Zaiou, Ahmed Bakillah
The most important function of high density lipoprotein (HDL) is its ability to remove cholesterol from cells and tissues involved in the early stages of atherosclerosis back to the liver for excretion. The ATP-binding cassette transporters ABCA1 and ABCG1 are responsible for the major part of cholesterol efflux to HDL in macrophage foam cells. Thus, promoting the process of reverse cholesterol transport (RCT) by upregulating mainly ABCA1 remains one of the potential targets for the development of new therapeutic agents against atherosclerosis...
May 3, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29748333/hepatic-overexpression-of-endothelial-lipase-lowers-hdl-high-density-lipoprotein-but-maintains-reverse-cholesterol-transport-in-mice-role-of-sr-bi-scavenger-receptor-class-b-type-i-abca1-atp-binding-cassette-transporter-a1-dependent-pathways
#10
Shunichi Takiguchi, Makoto Ayaori, Emi Yakushiji, Takafumi Nishida, Kazuhiro Nakaya, Makoto Sasaki, Maki Iizuka, Harumi Uto-Kondo, Yoshio Terao, Makiko Yogo, Tomohiro Komatsu, Masatsune Ogura, Katsunori Ikewaki
OBJECTIVE: Reverse cholesterol transport (RCT) is a major mechanism by which HDL (high-density lipoprotein) protects against atherosclerosis. Endothelial lipase (EL) reportedly reduces HDL levels, which, in theory, would increase atherosclerosis. However, it remains unclear whether EL affects RCT in vivo. APPROACH AND RESULTS: Adenoviral vectors expressing EL or luciferase were intravenously injected into mice, and a macrophage RCT assay was performed. As expected, hepatic EL overexpression markedly reduced HDL levels...
May 10, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29747087/hdl-cholesterol-efflux-capacity-and-cholesteryl-ester-transfer-are-associated-with-body-mass-but-are-not-changed-by-diet-induced-weight-loss-a-randomized-trial-in-abdominally-obese-men
#11
Charlotte P J Talbot, Jogchum Plat, Peter J Joris, Maurice Konings, Yvo H A M Kusters, Casper G Schalkwijk, Andreas Ritsch, Ronald P Mensink
BACKGROUND AND AIMS: Obesity is associated with a lower HDL-mediated cholesterol efflux from macrophages and a higher CETP (cholesteryl ester transfer protein) activity, but effects of weight loss are not clear. In addition, associations with visceral and subcutaneous adipose tissue are not known. We therefore investigated effects of diet-induced weight loss on HDL-mediated cholesterol efflux and cholesterol ester (CE) transfer in abdominally obese men. Differences between normal-weight and abdominally obese men were also examined...
April 28, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29738371/apoa-1-mimetic-peptide-elk-2a2k2e-decreases-inflammatory-factor-levels-via-the-abca1-jak2-stat3-ttp-axis-in-thp-1-derived-macrophages
#12
Jia-Lin Wang, Duo Gong, Xin-Yan Hu, Su Wu, Xi-Long Zheng, Jie Wu, Xiao-Er Tang, Da-Wei Zhang, Chao-Ke Tang
OBJECTIVE: The aim of this study was to determine whether the apolipoprotein A-1 (apoA-1) mimetic peptide ELK-2A2K2E regulates inflammatory cytokine expression via activating the ATP-binding cassette transporter A1 (ABCA1)-janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3)- tristetraprolin (TTP) signaling pathway in THP-1 macrophage-derived foam cells. METHODS AND RESULTS: The cells were treated with the apoA-1 mimetic peptide ELK-2A2K2E at different concentrations (0, 20, 40, 80 μg/ml) or incubated with ELK-2A2K2E (40 μg/ml) for different times (0, 6, 12, 24 h)...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29736189/investigation-of-the-influence-of-high-glucose-on-molecular-and-genetic-responses-an-in-vitro-study-using-a-human-intestine-model
#13
Tugce Boztepe, Sukru Gulec
Background: Dietary glucose consumption has increased worldwide. Long-term high glucose intake contributes to the development of obesity and type 2 diabetes mellitus (T2DM). Obese people tend to eat glucose-containing foods, which can lead to an addiction to glucose, increased glucose levels in the blood and intestine lumen, and exposure of intestinal enterocytes to high dietary glucose. Recent studies have documented a role for enterocytes in glucose sensing. However, the molecular and genetic relationship between high glucose levels and intestinal enterocytes has not been determined...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29733805/il-17a-mcp-1-ccr-2-and-abca1-polymorphisms-in-children-with-non-alcoholic-fatty-liver-disease
#14
Ulas Emre Akbulut, Hamdi Cihan Emeksiz, Senol Citli, Hamdi Cihan Emeksiz, Hatice Ayca Ata Korkmaz, Gaye Baki
OBJECTIVE: The prevalence of non-alcoholic fatty liver disease in children has risen significantly, owing to the worldwide childhood obesity epidemic in the last two decades. Non-alcoholic fatty liver disease is closely linked to sedentary lifestyle, increased body mass index, and visceral adiposity. In addition, individual genetic variations also have a role in the development and progression of non-alcoholic fatty liver disease. The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease...
May 4, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29724005/cholesterol-efflux-does-it-contribute-to-aortic-stiffening
#15
REVIEW
Shutan Liao, Craig S McLachlan
Aortic stiffness during cardiac contraction is defined by the rigidity of the aorta and the elastic resistance to deformation. Recent studies suggest that aortic stiffness may be associated with changes in cholesterol efflux in endothelial cells. This alteration in cholesterol efflux may directly affect endothelial function, extracellular matrix composition, and vascular smooth muscle cell function and behavior. These pathological changes favor an aortic stiffness phenotype. Among all of the proteins participating in the cholesterol efflux process, ATP binding cassette transporter A1 (ABCA1) appears to be the main contributor to arterial stiffness changes in terms of structural and cellular function...
May 1, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29712758/microrna-33-regulates-the-population-of-peripheral-inflammatory-ly6c-high-monocytes-through-dual-pathways
#16
Osamu Baba, Takahiro Horie, Tetsushi Nakao, Daihiko Hakuno, Yasuhiro Nakashima, Hitoo Nishi, Yasuhide Kuwabara, Masataka Nishiga, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Masahiro Kimura, Ritsuko Hanada, Masahiro Kawahara, Takeshi Kimura, Koh Ono
MicroRNA (miR)-33 targets ATP-binding cassette transporter A1 (ABCA1), and its deficiency increases serum HDL-cholesterol (HDL-C) and ameliorates atherosclerosis. Although we previously reported that miR-33 deficiency increased peripheral Ly6Chigh monocytes on ApoE-deficient background, the effect of miR-33 on monocyte population is not fully elucidated especially on wild-type (WT) background.We found that Ly6Chigh monocytes in miR-33-/- mice were decreased in peripheral blood and increased in bone marrow (BM)...
April 30, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29712723/modification-by-isolevuglandins-highly-reactive-%C3%AE-ketoaldehydes-deleteriously-alters-hdl-structure-and-function
#17
Linda S May-Zhang, Valery Yermalitsky, Jiansheng Huang, Tiffany Pleasent, Mark S Borja, Michael N Oda, W Gray Jerome, Patricia G Yancey, MacRae F Linton, Sean S Davies
Cardiovascular disease (CVD) risk depends on HDL function, not HDL-cholesterol (HDL-C). Isolevuglandins (IsoLGs) are lipid dicarbonyls that react with lysine residues of proteins and phosphatidylethanolamine. IsoLG adducts are elevated in atherosclerosis. The consequences of IsoLG modification of HDL have not been studied. We hypothesized that IsoLG modification of apoA-I deleteriously alters HDL function. We determined the effect of IsoLG on HDL structure-function, and whether pentylpyridoxamine (PPM), a dicarbonyl scavenger, can preserve HDL function...
April 30, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29710032/effects-of-chronic-whey-protein-supplementation-on-atherosclerosis-in-apoe-mice
#18
Zheng Zhang, Ru Zhang, Zhi-Zhen Qin, Jia-Ping Chen, Jia-Ying Xu, Li-Qiang Qin
Whey protein is associated with improvement of metabolic syndrome. This study aimed to evaluate effects of whey protein on atherosclerosis in ApoE-/- mice. Male ApoE-/- mice were fed with a high-fat/cholesterol diet (HFCD), or HFCD supplemented with 10% or 20% whey protein for 18 wk. At the end of experiment, serum lipid profiles and inflammatory cytokines were assayed. Livers were examined using HE staining and Oil Red O staining. Aortas were used for en face and cryosection analyses to observe aortic lesions...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29703573/il-8-negatively-regulates-abca1-expression-and-cholesterol-efflux-via-upregulating-mir-183-in-thp-1-macrophage-derived-foam-cells
#19
Xiao-Er Tang, Heng Li, Ling-Yan Chen, Xiao-Dan Xia, Zhen-Wang Zhao, Xi-Long Zheng, Guo-Jun Zhao, Chao-Ke Tang
OBJECTIVE: Previous studies suggest that IL-8 has an important role in the regulation of cholesterol efflux, but whether miRNAs are involved in this process is still unknown. The purpose of this study is to explore whether IL-8 promotes cholesterol accumulation by enhancing miR-183 expression in macrophages and its underlying mechanism. METHODS AND RESULTS: Treatment of THP-1 macrophage-derived foam cells with IL-8 decreased ABCA1 expression and cholesterol efflux...
April 24, 2018: Cytokine
https://www.readbyqxmd.com/read/29695588/mindin-deficiency-in-macrophages-protects-against-foam-cell-formation-and-atherosclerosis-by-targeting-lxr-%C3%AE
#20
Cheng Zhang, Juan-Juan Qin, Fu-Han Gong, Jing-Jing Tong, Wen-Lin Cheng, Haiping Wang, Yan Zhang, Xueyong Zhu, Zhi-Gang She, Hao Xia, Li-Hua Zhu
Abstract Background - Mindin, which is a highly conserved ECM protein, has been documented to play pivotal roles in regulating angiogenesis, inflammatory processes and immune responses. The aim of this study was to assess whether mindin contributes to the development of atherosclerosis. Methods and Results - A significant upregulation of Mindin expression was observed in the serum, arteries and atheromatous plaques of ApoE-/-  mice after HFD treatment. Mindin-/- ApoE-/- mice and macrophage-specific mindin overexpression in ApoE-/- mice (Lyz2-mindin-TG) were generated to evaluate the effect of mindin on the development of atherosclerosis...
April 25, 2018: Clinical Science (1979-)
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