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https://www.readbyqxmd.com/read/28546132/identification-of-direct-target-genes-of-mir-7-mir-9-mir-96-and-mir-182-in-the-human-breast-cancer-cell-lines-mcf-7-and-mda-mb-231
#1
Hamidreza Moazzeni, Ali Najafi, Marzieh Khani
Some microRNAs have carcinogenic or tumor suppressive effects in breast cancer, which is the most common cancer in women worldwide. MiR-7 and miR-9 are tumor suppressor microRNAs, which induce apoptosis and inhibit proliferation in breast cancer cells. Moreover, miR-96 and miR-182 are onco-microRNAs that increase proliferation, migration, and tumorigenesis in breast cancer cells. This study aimed to identify the direct target genes of these four microRNAs in the human breast cancer cell lines MCF-7 and MDA-MB-231...
May 22, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28529180/structure-function-relationships-in-reconstituted-hdl-focus-on-antioxidative-activity-and-cholesterol-efflux-capacity
#2
Alexandre M O Cukier, Patrice Therond, Svetlana A Didichenko, Isabelle Guillas-Baudouin, M John Chapman, Samuel D Wright, Anatol Kontush
AIMS: High-density lipoprotein (HDL) contains multiple components that endow it with biological activities. Apolipoprotein A-I (apoA-I) and surface phospholipids contribute to these activities; however, structure-function relationships in HDL particles remain incompletely characterized. METHODS: Reconstituted HDLs (rHDLs) were prepared from apoA-I and soy phosphatidylcholine (PC) at molar ratios of 1:50, 1:100 and 1:150. Oxidative status of apoA-I was varied using controlled oxidation of Met112 residue...
May 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28527383/tributyltin-and-triphenyltin-exposure-promotes-in-vitro-adipogenic-differentiation-but-alters-the-adipocyte-phenotype-in-rainbow-trout
#3
Esmail Lutfi, Natàlia Riera-Heredia, Marlon Córdoba, Cinta Porte, Joaquim Gutiérrez, Encarnación Capilla, Isabel Navarro
Numerous environmental pollutants have been identified as potential obesogenic compounds affecting endocrine signaling and lipid homeostasis. Among them, well-known organotins such as tributyltin (TBT) and triphenyltin (TPT), can be found in significant concentrations in aquatic environments. The aim of the present study was to investigate in vitro the effects of TBT and TPT on the development and lipid metabolism of rainbow trout (Onchorynchus mykiss) primary cultured adipocytes. Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα) protein expression when compared to a control, both in the presence or absence of lipid mixture...
May 8, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28526436/intracranial-il-17a-overexpression-decreases-cerebral-amyloid-angiopathy-by-upregulation-of-abca1-in-an-animal-model-of-alzheimer-s-disease
#4
Junling Yang, Jinghong Kou, Robert Lalonde, Ken-Ichiro Fukuchi
Neuroinflammation is a pervasive feature of Alzheimer's disease (AD) and characterized by activated microglia, increased proinflammatory cytokines and/or infiltrating immune cells. T helper 17 (Th17) cells are found in AD brain parenchyma and interleukin-17A (IL-17A) is identified around deposits of aggregated amyloid β protein (Aβ). However, the role of IL-17A in AD pathogenesis remains elusive. We overexpressed IL-17A in an AD mouse model via recombinant adeno-associated virus serotype 5 (rAAV5)-mediated intracranial gene delivery...
May 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28521806/high-density-lipoprotein-promoting-proliferation-and-migration-of-type-ii-alveolar-epithelial-cells-during-inflammation-state
#5
Zhongji Yu, Jingru Jin, Yuhui Wang, Jian Sun
BACKGROUND: To investigate the effect and mechanism of high density lipoprotein (HDL) on type II alveolar epithelial cells during inflammation state. METHODS: The original generation of type II alveolar epithelial cells were separated in rats and treated with PBS/LPS/HDL/HDL + LPS. To observe the proliferation and migration of type II alveolar epithelial cells with bromodeoxyuridine(BrdU) assay, transwell assay and wound healing experiments. In addition, western blot detected the expression of TP-binding cassette transporter A1 (ABCA1), cystic fibrosis transmembrane conductance regulator (CFTR) and the phosphorylation of AKT/extracellular signal-regulated kinase(ERK)/mitogen-activated protein kinase(MAPK)...
May 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28515138/dalcetrapib-and-anacetrapib-differently-impact-hdl-structure-and-function-in-rabbits-and-monkeys
#6
Mathieu R Brodeur, David Rhainds, Daniel Charpentier, Téodora Mihalache-Avram, Mélanie Mecteau, Geneviève Brand, Evelyne Chaput, Anne Perez, Eric J Niesor, Eric Rhéaume, Cyrille Maugeais, Jean-Claude Tardif
Inhibition of cholesteryl ester transfer protein (CETP) increases high density lipoprotein cholesterol (HDL-C) levels. However, circulating CETP level varies and the impact of its inhibition in species with high CETP levels on HDL structure and function remains poorly characterized. This study investigated the effects of dalcetrapib and anacetrapib, the two CETP inhibitors (CETPi) currently tested in large clinical outcome trials, on HDL particle subclass distribution and cholesterol efflux capacity of serum in rabbits and monkeys...
May 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28505344/genetics-of-glaucoma
#7
Janey L Wiggs, Louis R Pasquale
Genetic and genomic studies, including genome-wide association studies (GWAS) have accelerated the discovery of genes contributing to glaucoma, the leading cause of irreversible blindness world-wide. Glaucoma can occur at all ages, with Mendelian inheritance typical for rare early onset disease (before age 40) and complex inheritance evident in common adult-onset forms of disease. Recent studies have suggested possible therapeutic targets for some patients with early-onset glaucoma based on the molecular and cellular events caused by MYOC, OPTN and TBK1 mutations...
May 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28502803/gene-co-expression-networks-identify-trem2-and-tyrobp-as-major-hubs-in-human-apoe-expressing-mice-following-traumatic-brain-injury
#8
Emilie L Castranio, Anais Mounier, Cody M Wolfe, Kyong Nyon Nam, Nicholas F Fitz, Florent Letronne, Jonathan Schug, Radosveta Koldamova, Iliya Lefterov
Traumatic brain injury (TBI) is strongly linked to an increased risk of developing dementia, including chronic traumatic encephalopathy and possibly Alzheimer's disease (AD). APOEε4 allele of human Apolipoprotein E (APOE) gene is the major genetic risk factor for late onset AD and has been associated with chronic traumatic encephalopathy and unfavorable outcome following TBI. To determine if there is an APOE isoform-specific response to TBI we performed controlled cortical impact on 3-month-old mice expressing human APOE3 or APOE4 isoforms...
May 11, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28500865/dihydromyricetin-ameliorates-atherosclerosis-in-ldl-receptor-deficient-mice
#9
Ting Ting Liu, Yi Zeng, Kun Tang, XueMeng Chen, Wei Zhang, Xiao Le Xu
BACKGROUND AND AIMS: Dihydromyricetin, the most abundant flavonoid in Ampelopsis grossedentata, exerts numerous pharmacological activities, including anti-inflammatory, antioxidant, hepatoprotective, and lipid regulatory activities; however, its protective effect against atherosclerosis remains poorly understood. The aim of the present study was to evaluate the effects of dihydromyricetin on high fat diet (HFD)-induced atherosclerosis using LDL receptor deficient (LDLr(-/-)) mice. METHODS: Blood samples were collected for determination of serum lipid profiles, oxidized LDL (ox-LDL) and pro-inflammatory cytokines...
May 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28492976/squalene-promotes-cholesterol-homeostasis-in-macrophage-and-hepatocyte-cells-via-activation-of-liver-x-receptor-lxr-%C3%AE-and-%C3%AE
#10
Hoang Thi Minh Hien, Nguyen Cam Ha, Le Thi Thom, Dang Diem Hong
OBJECTIVE: To examine the effect of squalene on liver X receptors (LXRs) that regulate target genes associated with reverse cholesterol transport and thus control whole-body cholesterol homeostasis. RESULTS: To examine the effect of squalene on liver X receptors (LXRs) that regulate target genes associated with reverse cholesterol transport and thus control whole-body cholesterol homeostasis. Squalene significantly stimulated the transactivation of liver X receptor modulator LXRα and LXRβ...
May 10, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28486149/dietary-supplementation-with-long-chain-monounsaturated-fatty-acid-isomers-decreases-atherosclerosis-and-alters-lipoprotein-proteomes-in-ldlr-mice
#11
Zhi-Hong Yang, Scott M Gordon, Denis Sviridov, Shuibang Wang, Robert L Danner, Milton Pryor, Boris Vaisman, Yuka Shichijo, Nobushige Doisaki, Alan T Remaley
BACKGROUND AND AIMS: Concentrated fish oils, containing a mixture of long-chain monounsaturated fatty acids (LCMUFA) with aliphatic chains longer than 18 C atoms (i.e., C20:1 and C22:1), have been shown to attenuate atherosclerosis development in mouse models. It is not clear, however, how individual LCMUFA isomers may act on atherosclerosis. METHODS: In the present study, we used saury fish oil-derived concentrates enriched in either C20:1 or C22:1 isomer fractions to investigate their individual effect on atherosclerosis and lipoprotein metabolism...
April 25, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28482635/the-anti-amyloid-%C3%AE-and-neuroprotective-properties-of-a-novel-tricyclic-pyrone-molecule
#12
Izumi Maezawa, Bende Zou, Jacopo Di Lucente, William S Cao, Conrado Pascual, Sahani Weerasekara, Man Zhang, Xinmin Simon Xie, Duy H Hua, Lee-Way Jin
There is an urgent unmet need for new therapeutics for Alzheimer's disease (AD), the most common cause of dementia in the elderly. Therapeutic approaches targeting amyloid-β (Aβ) and its downstream toxicities have become major strategies in AD drug development. We have taken a rational design approach and synthesized a class of tricyclic pyrone (TP) compounds that show anti-Aβ and other neuroprotective actions. The in vivo efficacy of a lead TP named CP2 to ameliorate AD-like pathologies has been shown in mouse models...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28479366/cholesterol-accumulation-in-dendritic-cells-links-the-inflammasome-to-acquired-immunity
#13
Marit Westerterp, Emmanuel L Gautier, Anjali Ganda, Matthew M Molusky, Wei Wang, Panagiotis Fotakis, Nan Wang, Gwendalyn J Randolph, Vivette D D'Agati, Laurent Yvan-Charvet, Alan R Tall
Autoimmune diseases such as systemic lupus erythematosus (SLE) are associated with increased cardiovascular disease and reduced plasma high-density lipoprotein (HDL) levels. HDL mediates cholesterol efflux from immune cells via the ATP binding cassette transporters A1 and G1 (ABCA1/G1). The significance of impaired cholesterol efflux pathways in autoimmunity is unknown. We observed that Abca1/g1-deficient mice develop enlarged lymph nodes (LNs) and glomerulonephritis suggestive of SLE. This lupus-like phenotype was recapitulated in mice with knockouts of Abca1/g1 in dendritic cells (DCs), but not in macrophages or T cells...
May 4, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28476857/apolipoprotein-a-ii-alters-the-proteome-of-human-lipoproteins-and-enhances-cholesterol-efflux-from-abca1
#14
John T Melchior, Scott E Street, Allison B Andraski, Jeremy D Furtado, Frank M Sacks, Rebecca L Shute, Emily I Greve, Debi K Swertfeger, Hailong Li, Amy S Shah, L Jason Lu, W Sean Davidson
High density lipoproteins (HDL) are a heterogeneous family of particles that vary in size, composition and function. The structure of most HDL is maintained by two scaffold proteins, apolipoprotein (apo)A-I and apoA-II, but up to 95 other accessory proteins have been found associated with the particles. Recent evidence suggests these accessory proteins are distributed across various subspecies and drive specific biological functions. Unfortunately, our understanding of the molecular composition of such subspecies is limited...
May 5, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28464932/interaction-between-fto-rs9939609-and-the-native-american-origin-abca1-rs9282541-affects-bmi-in-the-admixed-mexican-population
#15
Marisela Villalobos-Comparán, Bárbara Antuna-Puente, María Teresa Villarreal-Molina, Samuel Canizales-Quinteros, Rafael Velázquez-Cruz, Paola León-Mimila, Hugo Villamil-Ramírez, Juan Antonio González-Barrios, José Luis Merino-García, María Rocío Thompson-Bonilla, Diego Jarquin, Osvaldo Erik Sánchez-Hernández, Martha Eunice Rodríguez-Arellano, Carlos Posadas-Romero, Gilberto Vargas-Alarcón, Francisco Campos-Pérez, Manuel Quiterio, Jorge Salmerón-Castro, Alessandra Carnevale, Sandra Romero-Hidalgo
BACKGROUND: The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations. METHODS: A total of 3938 adults and 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous and visceral adipose tissue biopsies from 22 class III obesity patients were analyzed for FTO and ABCA1 mRNA expression...
May 2, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28459714/xxk-regulates-rct-via-improving-hdl-synthesis-maturation-and-catabolism
#16
Guang-Xin Dong, Wen-Wen Li, Ruo-Zhu Wang, Wen-Jun Zou, Zhen-Dong Zhong, Bo-Gang Li
Di'ao Xinxuekang (XXK) is a herbal product in China and Netherlands that has been clinically shown to attenuate atherosclerosis (AS); however, the underlying anti-atherosclerotic mechanism remains unclear. Due to its role in cholesterol homeostasis, reverse cholesterol transport (RCT) is a potential target for these beneficial effects. This study investigated the effects of XXK on RCT and related proteins. After treating ApoE-deficient mice with XXK for 8 weeks, we observed an increase in the expression level of ATP binding cassette transporter A1 (ABCA1) and ATP binding cassette transporter G1 (ABCG1), which in turn stimulated cholesterol efflux and reduced aortic atherosclerotic lesion area...
April 25, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28455345/bilirubin-decreases-macrophage-cholesterol-efflux-and-atp-binding-cassette-transporter-a1-protein-expression
#17
Dongdong Wang, Anela Tosevska, Elke H Heiß, Angela Ladurner, Christine Mölzer, Marlies Wallner, Andrew Bulmer, Karl-Heinz Wagner, Verena M Dirsch, Atanas G Atanasov
BACKGROUND: Mild but chronically elevated circulating unconjugated bilirubin is associated with reduced total and low-density lipoprotein cholesterol concentration, which is associated with reduced cardiovascular disease risk. We aimed to investigate whether unconjugated bilirubin influences macrophage cholesterol efflux, as a potential mechanism for the altered circulating lipoprotein concentrations observed in hyperbilirubinemic individuals. METHODS AND RESULTS: Cholesterol efflux from THP-1 macrophages was assessed using plasma obtained from normo- and hyperbilirubinemic (Gilbert syndrome) humans (n=60 per group) or (heterozygote/homozygote Gunn) rats (n=20 per group) as an acceptor...
April 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28450348/melanocortin-1-receptor-signaling-regulates-cholesterol-transport-in-macrophages
#18
Petteri Rinne, Martina Rami, Salla L Nuutinen, Donato Santovito, Emiel P C van der Vorst, Raquel Guillamat-Prats, Leo-Pekka Lyytikäinen, Emma Raitoharju, Niku Oksala, Larisa Ring, Minying Cai, Victor J Hruby, Terho J Lehtimäki, Christian Weber, Sabine Steffens
Background -The melanocortin 1 receptor (MC1-R) is expressed by monocytes and macrophages, where it exerts anti-inflammatory actions upon stimulation with its natural ligand α-melanocyte-stimulating hormone (α-MSH). The present study was designed to investigate the specific role of MC1-R in the context of atherosclerosis and possible regulatory pathways of MC1-R beyond anti-inflammation. Methods -Human and mouse atherosclerotic samples and primary mouse macrophages were used to study the regulatory functions of MC1-R...
April 27, 2017: Circulation
https://www.readbyqxmd.com/read/28445900/central-and-peripheral-glucagon-reduces-hyperlipidemia-in-rats-and-hamsters
#19
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Hiren M Patel, Dheerendra Pandey, Dipam Patel, Kiran Shah, Rajesh Bahekar, Gaurang B Shah, Mukul R Jain
Increased lipid levels in blood contribute to increasing the risk of diabetic complications. Glucagon exerts lipid lowering effects in diabetic state. However, the mechanism behind the lipid reduction by glucagon independent of glucose homeostasis is not well understood. We assessed the actions of glucagon on lipid modulation in blood and markers in liver in hyperlipidemic hamsters and rats. Male Sprague Dawley rats and Golden Syrian hamsters on a hyperlipidemic diet for 2 weeks were administered a single dose of glucagon by subcutaneous (SC, 150 and 300 µg/kg) or intracerebroventricular (ICV, 15 and 30 µg/animal) route...
April 26, 2017: Drug Research
https://www.readbyqxmd.com/read/28442497/an-in-silico-model-of-retinal-cholesterol-dynamics-rcd-model-insights-into-the-pathophysiology-of-dry-age-related-macular-degeneration
#20
Seyedeh Maryam Zekavat, James Lu, Cyrille Maugeais, Norman A Mazer
We developed an in-silico mathematical model of retinal cholesterol (Ch) dynamics (RCD) to quantify the physiological rate of Ch turnover in the rod outer segment (ROS), the lipoprotein transport mechanisms by which Ch enters and leaves the outer retina, and the rates of drusen growth and macrophage-mediated clearance in dry Age-Related Macular Degeneration (AMD). Based on existing experimental data and mechanistic hypotheses, we estimate the Ch turnover rate in the ROS to be 1-6 pg/mm2/min, dependent on the rate of Ch recycling in the outer retina, and find comparable rates for LDL receptor-mediated endocytosis of Ch by the retinal pigment epithelium (RPE), ABCA1-mediated Ch transport from the RPE to outer retina, ABCA1-mediated Ch efflux from the RPE to choroid, and the secretion of 70 nm ApoB-Ch particles from the RPE...
April 25, 2017: Journal of Lipid Research
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