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JOURNAL ARTICLE
Bretislav Lipovy, Martin Hladik, Katerina Vyklicka, Iva Kocmanova, Martina Lengerova, Leos Kren, Michal Srnik, Jan Bohm, Petr Andrla, Petra Borilova Linhartova
Patients with burn injury and inhalation injury are highly susceptible to infectious complications, including opportunistic pathogens, due to the loss of skin cover and mucosal damage of respiratory tract as well as the disruption of homeostasis. This case report, a 34-year-old man suffered critical burns, provides the first literature description of triple-impact immunoparalysis (critical burns, inhalation injury, and SARS-CoV-2 infection), leading to a lethal multifocal infection caused by several fungi including very rare environmental representatives Metschnikowia pulcherrima and Wickerhamomyces anomalus...
April 22, 2024: Folia Microbiologica
#2
JOURNAL ARTICLE
Mingjie Shi, Yue Wei, Runmin Guo, Fei Luo
BACKGROUND: Sepsis is a major contributor to morbidity and mortality among hospitalized patients. This study aims to identify markers associated with the severity and prognosis of sepsis, providing new approaches for its management and treatment. METHODS: Data were mined from the Gene Expression Omnibus (GEO) databases and were analyzed by multiple statistical methods like the Spearman correlation coefficient, Kaplan-Meier analysis, Cox regression analysis, and functional enrichment analysis...
2024: Journal of Inflammation Research
#3
JOURNAL ARTICLE
Yuanqun Zhou, Yu Zhu, Yue Wu, Xinming Xiang, Xingnan Ouyang, Liangming Liu, Tao Li
INTRODUCTION: Cardiac dysfunction after sepsis the most common and severe sepsis-related organ failure. The severity of cardiac damage in sepsis patients was positively associated to mortality. It is important to look for drugs targeting sepsis-induced cardiac damage. Our previous studies found that 4-phenylbutyric acid (PBA) was beneficial to septic shock by improving cardiovascular function and survival, while the specific mechanism is unclear. OBJECTIVES: We aimed to explore the specific mechanism and PBA for protecting cardiac function in sepsis...
April 19, 2024: Metabolomics: Official Journal of the Metabolomic Society
#4
JOURNAL ARTICLE
Kazuhiko Kawata, Shinya Hatano, Akemi Baba, Keisuke Imabayashi, Yoshihiro Baba
Sepsis is a systemic inflammatory response to a severe, life-threatening infection with organ dysfunction. Although there is no effective treatment for this fatal illness, a deeper understanding of the pathophysiological basis of sepsis and its underlying mechanisms could lead to the development of new treatment approaches. Here, we demonstrate that the selective Bruton's tyrosine kinase (Btk) inhibitor acalabrutinib augments survival rates in a lipopolysaccharide (LPS)-induced septic model. Our in vitro and in vivo findings both indicate that acalabrutinib reduces IL-6 production specifically in marginal zone B (MZ B) cells rather than in macrophages...
2024: Frontiers in Immunology
#5
JOURNAL ARTICLE
Vaclav Tegl, Jan Horak, Lukas Nalos, Michala Horakova, Milan Stengl, Martin Matejovic, Jan Benes
OBJECTIVES: The use of hemoadsorption (HA) has become popular in the treatment of vasoplegic states associated with massive cytokine release, including septic shock. However, this approach does not seem to be based on robust evidence, and it does not follow international guidelines. To understand the pathophysiological rationale and timing of HA, we conducted a large animal septic shock experiment. DESIGN: Prospective randomized large-animal peritoneal septic shock experiment...
April 18, 2024: Intensive Care Medicine Experimental
#6
JOURNAL ARTICLE
Yatin Mehta, Abdul Samad Ansari, Amit Kumar Mandal, Dipanjan Chatterjee, Gauri Shankar Sharma, Prachee Sathe, Purvesh V Umraniya, Rajib Paul, Sachin Gupta, Vinod Singh, Yogendra Pal Singh
BACKGROUND: Septic shock is a severe form of sepsis characterised by deterioration in circulatory and cellular-metabolic parameters. Despite standard therapy, the outcomes are poor. Newer adjuvant therapy, such as CytoSorb® extracorporeal haemoadsorption device, has been investigated and shown promising outcome. However, there is a lack of some guidance to make clinical decisions on the use of CytoSorb® haemoadsorption as an adjuvant therapy in septic shock in Indian Setting...
March 9, 2024: World Journal of Critical Care Medicine
#7
JOURNAL ARTICLE
Xia Li, Sheng Wang, Jun Ma, Su-Ge Bai, Su-Zhen Fu
BACKGROUND: Thrombocytopenia is common in patients with sepsis and septic shock. AIM: To analyse the decrease in the number of platelets for predicting bloodstream infection in patients with sepsis and septic shock in the intensive care unit. METHODS: A retrospective analysis of patients admitted with sepsis and septic shock in Xingtai People Hospital was revisited. Patient population characteristics and laboratory data were collected for analysis...
March 9, 2024: World Journal of Critical Care Medicine
#8
REVIEW
Emanuele Valeriani, Antonio Falletta, Daniele Pastori, Angelo Porfidia, Claudio Maria Mastroianni, Silvia Di Bari, Eleonora Motta, Pasquale Pignatelli, Alessandra Oliva
BACKGROUND: Midregional-proAdrenomedullin (MR-proADM) has been recently proposed as a tool in patients with sepsis and septic shock. Our aim was to evaluate the prognostic role of MR-proADM in hospitalized patients with sepsis and septic shock. METHODS: PRISMA guideline was followed. MEDLINE and EMBASE were searched up to June 2023. Primary outcome was mean difference in MR-proADM among survivors and nonsurvivors, secondary outcome mean difference in MR-proADM according to infection severity and type...
April 17, 2024: European Journal of Clinical Investigation
#9
JOURNAL ARTICLE
Christian Fuchs, Christian S Scheer, Steffi Wauschkuhn, Marcus Vollmer, Konrad Meissner, Klaus Hahnenkamp, Matthias Gründling, Sixten Selleng, Thomas Thiele, Rainer Borgstedt, Sven-Olaf Kuhn, Sebastian Rehberg, Sean Selim Scholz
BACKGROUND: The decision to maintain or halt antiplatelet medication in septic patients admitted to intensive care units presents a clinical dilemma. This is due to the necessity to balance the benefits of preventing thromboembolic incidents and leveraging anti-inflammatory properties against the increased risk of bleeding. METHODS: This study involves a secondary analysis of data from a prospective cohort study focusing on patients diagnosed with severe sepsis or septic shock...
April 17, 2024: BMC Anesthesiology
#10
JOURNAL ARTICLE
Samuel Choice, Ashten Sherman, Katherine Holder, Elaine Harrington
This case reviews the clinical course of an elderly woman on chronic total parenteral nutrition who developed sepsis secondary to a rare, newly described gram-negative rod known as Phytobacter ursingii The patient noticed a leak in her Hickman catheter when infusing her nutrition. 24 hours after a new catheter was replaced, the patient developed fevers, chills and weakness. She presented to the hospital with hypotension and tachycardia, meeting shock criteria. Blood cultures grew P. ursingii, and the diagnosis of septic shock was confirmed...
April 16, 2024: BMJ Case Reports
#11
JOURNAL ARTICLE
Connor C Wang, Sonya Bharadwa, Olivia W Foley, Issac Domenech, Brenda Vega, Mary Towner, Emma L Barber
OBJECTIVE: Serum creatinine is a byproduct of muscle metabolism, and low creatinine is postulated to be associated with diminished muscle mass. This study examined the association between low pre-operative serum creatinine and post-operative outcomes. METHODS: This retrospective cohort study utilized the 2014-2021 National Surgical Quality Improvement Program to identify patients undergoing surgery with gynecologic oncologists. Patients with missing pre-operative creatinine, end-stage renal disease, sepsis, septic shock, dialysis, or pregnancy were excluded...
April 16, 2024: International Journal of Gynecological Cancer
#12
JOURNAL ARTICLE
Matthew S Chung, Neil Patel, George Abdelmalek, Daniel Coban, Stuart Changoor, Faisal Elali, Kumar Sinha, Ki Hwang, Arash Emami
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is a reliable procedure commonly performed in older patients with degenerative diseases of the cervical spine. Over 130,000 procedures are performed every year with an annual increase of 5%, and overall morbidity rates can reach as high as 19.3%, indicating a need for surgeons to gauge their patients' risk for adverse outcomes. Frailty is an age-associated decline in functioning of multiple organ systems and has been shown to predict adverse outcomes following various spine procedures...
June 2024: N Am Spine Soc J
#13
JOURNAL ARTICLE
Sepsis and Septic Shock in Patients Undergoing Thyroidectomy: Incidence, Risk Factors, and Outcomes.
Usama Waqar, Namrah Aziz, Ahmad Areeb Chaudhry, Haissan Iftikhar, Nadia Jivani, Syed Akbar Abbas
INTRODUCTION: Postoperative sepsis represents a rare complication following thyroidectomy. We aimed to explore the incidence, risk factors, sources, and outcomes of postoperative sepsis and septic shock among adult patients undergoing thyroidectomy. METHODS: Data from the American College of Surgeons National Surgical Quality Improvement Program were used in this retrospective cohort study. Patients aged ≥18 y who underwent elective thyroidectomy between 2005 and 2019 were included...
April 13, 2024: Journal of Surgical Research
#14
JOURNAL ARTICLE
Anwei Liu, Xiaogan Hou, Jing Nie, Qiang Wen, Zhiguo Pan
Decompression sickness (DCS) is caused by abrupt changes in extracorporeal pressure with varying severity. Symptoms range from mild musculoskeletal pain to severe organ dysfunction and death, especially among patients with chronic underlying disease. Here, we report an unusual case of a 49-year-old man who experienced DCS after a dive to a depth of 38 meters. The patient's symptoms progressed, starting with mild physical discomfort that progressed to disturbance of consciousness on the second morning. During hospitalization, we identified that in addition to DCS, he had also developed diabetic ketoacidosis, septic shock, and rhabdomyolysis...
2024: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
#15
JOURNAL ARTICLE
YiWen Fan, Jill Moser, Matijs van Meurs, Dorien Kiers, Jannie Marie Bülow Sand, Diana Julie Leeming, Peter Pickkers, Janette K Burgess, Matthijs Kox, Janesh Pillay
BACKGROUND: Sepsis is associated with high morbidity and mortality, primarily due to systemic inflammation-induced tissue damage, resulting organ failure, and impaired recovery. Regulated extracellular matrix (ECM) turnover is crucial for maintaining tissue homeostasis in health and in response to disease-related changes in the tissue microenvironment. Conversely, uncontrolled turnover can contribute to tissue damage. Systemic Inflammation is implicated to play a role in the regulation of ECM turnover, but the relationship between the two is largely unclear...
April 12, 2024: Critical Care: the Official Journal of the Critical Care Forum
#16
JOURNAL ARTICLE
Evelyn Yi Wen Chau, Afliza Abu Bakar, Aireen Binti Zamhot, Ida Zarina Zaini, Siti Norafida Binti Adanan, Dazlin Masdiana Binti Sabardin
BACKGROUND: The latest Surviving Sepsis Campaign 2021 recommends early antibiotics administration. However, Emergency Department (ED) overcrowding can delay sepsis management. This study aimed to determine the effect of ED overcrowding towards the management and outcome of sepsis patients presented to ED. METHODS: This was an observational study conducted among sepsis patients presented to ED of a tertiary university hospital from 18th January 2021 until 28th February 2021...
April 12, 2024: BMC Emergency Medicine
#17
REVIEW
Daniele Orso, Nicola Federici, Cristina Lio, Filippo Mearelli, Tiziana Bove
OBJECTIVE: The objective of this study was to verify whether any parameter among those used as the target for haemodynamic optimisation (e.g., mean arterial pressure, central venous oxygen saturation, systolic or diastolic dysfunction, CO2 gap, lactates, right ventricular dysfunction, and PvaCO2 /CavO2 ratio) is correlated with mortality in an undifferentiated population with sepsis or septic shock. METHODS: An umbrella review, searching MEDLINE, the Cochrane Database of Systematic Reviews, Health Technology Assessment Database, and the JBI Database of Systematic Reviews and Implementation Reports, was performed...
April 11, 2024: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
#18
JOURNAL ARTICLE
Farshad Abedi, Batool Zarei, Sepideh Elyasi
PURPOSE: Nowadays, it is largely accepted that albumin should not be used in hypoalbuminemia or for nutritional purpose. The most discussed indication of albumin at present is the resuscitation in shock states, especially distributive shocks such as septic shock. The main evidence-based indication is also liver disease. In this review, we provided updated evidence-based instruction for definite and potential indications of albumin administration in clinical practice, with appropriate dosing and duration...
April 12, 2024: European Journal of Clinical Pharmacology
#19
JOURNAL ARTICLE
Kai-Lee Chen, Ruey-Hsing Chou, Chun-Chin Chang, Chin-Sung Kuo, Jih-Hua Wei, Po-Hsun Huang, Shing-Jong Lin
INTRODUCTION: Known to have pleiotropic functions, high-density lipoprotein (HDL) helps to regulate systemic inflammation during sepsis. As preserving HDL-C level is a promising therapeutic strategy for sepsis, the interaction between HDL and sepsis worth further investigation. This study aimed to determine the impact of sepsis on HDL's anti-inflammatory capacity and explore its correlations with disease severity and laboratory parameters. METHODS AND MATERIALS: We enrolled 80 septic subjects admitted to the intensive care unit and 50 controls admitted for scheduled coronary angiography in this cross-sectional study...
2024: PloS One
#20
JOURNAL ARTICLE
Natalia Maldonado, Inmaculada López-Hernández, Luis Eduardo López-Cortés, Pedro María Martínez Pérez-Crespo, Pilar Retamar-Gentil, Andrea García-Montaner, Sandra De la Rosa Riestra, Adrián Sousa-Domínguez, Josune Goikoetxea, Ángeles Pulido-Navazo, María Del Valle Ortíz, Clara Natera-Kindelán, Alfredo Jover-Sáenz, Alfonso Del Arco-Jiménez, Carlos Armiñanzas-Castillo, Ana Isabel Aller-García, Jonathan Fernández-Suárez, Teresa Marrodán-Ciordia, Lucía Boix-Palop, Alejandro Smithson-Amat, José Ma Reguera-Iglesias, Fátima Galán-Sánchez, Alberto Bahamonde, Juan Manuel Sánchez Calvo, Isabel Gea-Lázaro, Inés Pérez-Camacho, Armando Reyes-Bertos, Berta Becerril-Carral, Álvaro Pascual, Jesús Rodríguez-Baño
OBJECTIVES: This study aimed to determine the association of E. coli microbiological factors with 30-day mortality in BSI patients presenting with a dysregulated response to infection (i.e., sepsis or septic shock). METHODS: Whole genome sequencing was performed on 224 E. coli isolates of patients with sepsis/septic shock, from 22 Spanish hospitals. Phylogroup, sequence type, virulence, antibiotic resistance and pathogenicity islands were assessed. A multivariable model for 30-day mortality including clinical and epidemiological variables was built, to which microbiological variables were hierarchically added...
April 8, 2024: Clinical Microbiology and Infection
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