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https://www.readbyqxmd.com/read/28423723/honokiol-an-activator-of-sirtuin-3-sirt3-preserves-mitochondria-and-protects-the-heart-from-doxorubicin-induced-cardiomyopathy-in-mice
#1
Vinodkumar B Pillai, Abhinav Kanwal, Yong Hu Fang, Willard W Sharp, Sadhana Samant, Jack Arbiser, Mahesh P Gupta
Doxorubicin is the chemotherapeutic drug of choice for a wide variety of cancers, and cardiotoxicity is one of the major side effects of doxorubicin treatment. One of the main cellular targets of doxorubicin in the heart is mitochondria. Mitochondrial sirtuin, SIRT3 has been shown to protect against doxorubicin-induced cardiotoxicity. We have recently identified honokiol (HKL) as an activator of SIRT3, which protects the heart from developing pressure overload hypertrophy. Here, we show that HKL-mediated activation of SIRT3 also protects the heart from doxorubicin-induced cardiac damage without compromising the tumor killing potential of doxorubicin...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412947/report-of-the-first-clinical-case-of-intestinal-trichomoniasis-caused-by-tritrichomonas-foetus-in-a-cat-with-chronic-diarrhoea-in-brazil
#2
Aline S Hora, Samantha I Miyashiro, Fabiana C Cassiano, Paulo E Brandão, Archivaldo Reche-Junior, Hilda F J Pena
BACKGROUND: Tritrichomonas foetus is an emergent and important enteric pathogen of cats, which causes prolonged diarrhoea in cats. CASE PRESENTATION: This study describes a T. foetus infection in a seven-month-old, entire male domestic shorthair kitten with a six-month history of persistent large intestinal diarrhoea, faecal incontinence, prostration, apathy and weight loss. Parasites were microscopically observed and confirmed by PCR and DNA sequencing. Molecular analyses were carried out comparing the sequence obtained in this study with T...
April 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28407445/lethal-bentazone-intoxication-a-report-of-two-cases
#3
Petar Škavić, Zijad Duraković, Marina Nestić
This study presents two cases of lethal bentazone poisonings, their clinical presentation, the course of the disease and the autopsy findings. The first is a 50-year-old male who had sprayed corn with a solution of bentazone and was admitted to the hospital with sweating, fever, nausea, vomiting of aqueous and hemorrhagic content, and bloody, watery stools. He was treated according to the symptoms including extracorporeal hemodialysis, but eventually suffered from multiorgan failure (acute respiratory failure, acute liver failure, coagulopathy, acute renal failure, metabolic acidosis, and gastrointestinal bleeding) and died 11...
April 13, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28364835/canine-tungiasis-high-prevalence-in-a-tourist-region-in-bahia-state-brazil
#4
Tatiani Vitor Harvey, Jorg Heukelbach, Maíra Siles Assunção, Thalna Magalhães Fernandes, Christiane Maria Barcellos Magalhães da Rocha, Renata Santiago Alberto Carlos
Tungiasis is a parasitic skin disease neglected by authorities, health professionals, and the general population. Its occurrence is significantly associated with poverty. A cross-sectional study was conducted to describe the prevalence of tungiasis, associated clinical signs and risk factors of the canine population at a tourist site in the city of Ilhéus, Bahia (northeast Brazil). All village households were visited and dogs inspected after authorization by owners. A semi-structured questionnaire was administered...
April 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28355402/budd-chiari-syndrome-secondary-to-catheter-associated-inferior-vena-cava-thrombosis
#5
Gustavo N Araujo, Luciane M Restelatto, Carlos A Prompt, Cristina Karohl
INTRODUCTION: Patients with chronic kidney disease (CKD) are at increased risk for thrombotic complications. The use of central venous catheters as dialysis vascular access additionally increases this risk. We describe the first case of Budd-Chiari syndrome (BCS) secondary to central venous catheter misplacement in a patient with CKD. CASE REPORT: A 30-year-old female patient with HIV/AIDS and CKD on hemodialysis was admitted to the emergency room for complaints of fever, prostration, and headache in the last six days...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28334100/an-organismal-concept-for-sengelia-radicans-gen-et-sp-nov-morphology-and-natural-history-of-an-early-devonian-lycophyte
#6
Kelly K S Matsunaga, Alexandru M F Tomescu
Background and Aims: Fossil plants are found as fragmentary remains and understanding them as natural species requires assembly of whole-organism concepts that integrate different plant parts. Such concepts are essential for incorporating fossils in hypotheses of plant evolution and phylogeny. Plants of the Early Devonian are crucial to reconstructing the initial radiation of tracheophytes, yet few are understood as whole organisms. Methods: This study assembles a whole-plant concept for the Early Devonian lycophyte Sengelia radicans gen...
February 20, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28322900/structural-variations-of-the-prostatic-urethra-within-the-prostate-predict-the-severities-of-obstructive-symptoms-a-prospective-multicenter-observational-study
#7
Young Hwii Ko, Tae-Hwan Kim, Phil Hyun Song, Byung Hoon Kim, Bum Soo Kim, Ki Ho Kim, Jaeho Cho
OBJECTIVE: To describe distinctive morphologic variations of the prostate associated with the prostatic urethra, and to determine whether structural changes of the urethra within the prostate resulting from gland enlargement, rather than prostrate volume itself, lead to male lower urinary tract symptom (LUTS). MATERIALS AND METHODS: After standardizing measurements, 7 ultrasonography-determined variables, that is, prostate volume, transitional zone volume, transitional zone-to-total volume ratio, presence of intraprostatic protrusion, prostatic urethral angle, prostatic urethral length (PUL), and PUL-to-volume ratio (rPUL), were obtained prospectively in 293 men who had not taken LUTS medication during the 3 months prior to initial visits...
March 18, 2017: Urology
https://www.readbyqxmd.com/read/28241896/salmonella-in-the-pork-production-chain-and-its-impact-on-human-health-in-the-european-union
#8
S Bonardi
Salmonella spp. comprise the second most common food-borne pathogens in the European Union (EU). The role of pigs as carriers of Salmonella has been intensively studied both on farm and at slaughter. Salmonella infection in pigs may cause fever, diarrhoea, prostration and mortality. However, most infected pigs remain healthy carriers, and those infected at the end of the fattening period could pose a threat to human health. Contamination of pig carcasses can occur on the slaughter line, and it is linked to cross-contamination from other carcasses and the presence of Salmonella in the environment...
February 28, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28240015/association-of-polymorphisms-in-the-vdr-cyp17-and-srd5a2-genes-and-prostate-cancer-among-lebanese-men
#9
Asmahan A El Ezzi, Monika T Baker, Wissam R Zaidan, Kalim M Hraiki, Mohammad A El Saidi, Ruhul H Kuddus
Aims: The goal of this study was to investigate possible associations of some single nucleotide polymorphisms (SNPs) in the VDR gene (the FokI, BsmI, ApaI and TaqαI loci), and the CYP17 gene (the MspA1I locus), and variable numbers of TA repeats in the SRD5A2 gene, with prostate cancer (PCa), among Lebanese men. Materials and Methods: Blood DNA samples of 50 subjects with confirmed PCa and 79 age-qualified controls were subjected to PCR or PCR-RFLP analyses, and the risk-bearing and protective alleles were identified...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28152205/saponin-profile-of-wild-asparagus-species
#10
Sara Jaramillo-Carmona, Rocío Rodriguez-Arcos, Ana Jiménez-Araujo, Sergio López, Juan Gil, Roberto Moreno, Rafael Guillén-Bejarano
The aim of this work was to study the saponin profiles from spears of different wild asparagus species in the context of its genetic diversity aside from geographical seed origin. They included Asparagus pseudoscaber Grecescu, Asparagus maritimus (L.) Mill., Asparagus brachiphyllus Turcz., Asparagus prostrates Dumort., and Asparagus officinalis L. The saponin analysis by LC-MS has shown that saponin profile from wild asparagus is similar to that previously described for triguero asparagus from Huétor-Tájar landrace (triguero HT), which had not ever been reported in the edible part of asparagus...
February 2, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28127435/dementia-gait-disturbance-and-urinary-incontinence-in-a-patient-with-pulmonary-sarcoidosis
#11
Gonzalo Labarca, Romina Ramirez, Ximena Monsalve, Isabel Mira-Avendano
Hydrocephalus is an uncommon presentation of neurosarcoidosis. We discuss the case of a 67-year-old woman with a prior diagnosis of hypothyroidism, systemic hypertension, and lung sarcoidosis who presented with a 1-month history of progressive impairment of consciousness leading to prostration and loss of sphincter control. At admission, patient was febrile with altered speech and without focalization. Laboratory results showed leucocytosis and mild anaemia. Cerebrospinal fluid (CSF) analysis was characterized by mild elevated protein level, increased cell count, normal glucose and adenosine deaminase (ADA), negative cytology, and no bacterial isolations...
September 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28024263/improved-survival-for-patients-with-de-novo-metastatic-prostate-cancer-in-the-last-20-years
#12
Kasper Drimer Berg, Frederik Birkebæk Thomsen, Marta K Mikkelsen, Inga J Ingimarsdóttir, Rikke B Hansen, Anne Mette T Kejs, Klaus Brasso
INTRODUCTION: During recent years, several new life-prolonging therapeutic options have been introduced for patients with metastatic prostate cancer (mPCa). The aim of the present study was to evaluate the changes in the survival of patients diagnosed with mPCa prior to and in the early period of the implementation of these new agents. PATIENTS AND METHODS: The study population consisted of 207 men diagnosed in 1997 and 316 men diagnosed in the period 2007-2013 with de novo mPCa and managed with initial endocrine therapy...
February 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/27979172/monoterpenoids-from-the-traditional-north-italian-vegetable-aruncus-dioicus-walter-fernald-var-vulgaris-maxim-h-hara-rosaceae
#13
Sebastian Granica, Pietro Fusani, Iwona Stanisławska, Jakub P Piwowarski, Dominique Melck, Andrea Motta, Christian Zidorn
Investigations of young shoots of Aruncus dioicus (Walter) Fernald var. vulgaris (Maxim.) H.Hara (Rosaceae), collected from the wild and used as vegetables in alpine provinces of Italy, yielded eight monoterpenoids. Besides known compounds, aruncin A, aruncide A, and cimicifugolide, five previously undescribed substances, aruncins C, D, and E, and aruncides D and E, were identified. Based on results from the full synthesis of aruncin B, structures of aruncin A and aruncide A were revised. Structures were established by HR mass spectrometry and extensive 1D and 2D NMR spectroscopy and based on data from synthetic aruncin B...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27941106/compliance-with-referral-advice-after-treatment-with-prereferral-rectal-artesunate-a-study-in-3-sub-saharan-african-countries
#14
Mohamadou Siribié, IkeOluwapo O Ajayi, Jesca Nsungwa-Sabiiti, Armande K Sanou, Ayodele S Jegede, Chinenye Afonne, Catherine O Falade, Melba Gomes
BACKGROUND:  Children aged <5 years were enrolled in a large study in 3 countries of sub-Saharan Africa because they had danger signs preventing them from being able to take oral medications. We examined compliance and factors associated with compliance with referral advice for those who were treated with rectal artesunate. METHODS:  Patient demographic data, speed of accessing treatment after danger signs were recognized, clinical symptoms, malaria microscopy, treatment-seeking behavior, and compliance with referral advice were obtained from case record forms of 179 children treated with prereferral rectal artesunate in a multicountry study...
December 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27876976/variation-in-clinical-markers-in-cattle-naturally-infected-with-bovine-tropical-theileriosis
#15
Rahul Parashar, Vikrant Sudan, Amit Kumar Jaiswal, Daya Shanker
124 cattle naturally infected with Theileria annulata were inspected for clinical markers. Clinical manifestations of general weakness, reduced appetite, pyrexia reaching 40-42 °C and lachrymal discharge were seen in more than 75 % of the infected animals. Presence of ticks on body, general dullness and depression, recumbency/prostration, oedema of dependent body parts, diarrhea, hypersalivation, pale mucous membranes and yellow colored urine were revealed by more than 50 % of the infected animals. Clinical manifestations of dehydration, abdominal distension/ascites, jaundice and haemoglobinuria were revealed by more than 25 % of the infected animals less than 25 % of the infected animals showed clinical manifestations of exophthalmia, constipation, melena, buccal cavity erosions, congested mucous membranes, nasal discharge and tachypnoea...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27859131/predators-suppress-herbivore-outbreaks-and-enhance-plant-recovery-following-hurricanes
#16
David A Spiller, Thomas W Schoener, Jonah Piovia-Scott
Understanding processes that may stabilize ecological systems confronted with rapidly changing environmental conditions is a key issue in ecology. We studied a system of highly fluctuating populations, the moth Achyra rantalis feeding on the plant Sesuvium portulacastrum in a group of small subtropical islands of the Bahamas. The plant is a prostrate inhabitant of shorelines, and consequently moths are highly vulnerable to being consumed by the ground-foraging lizard Anolis sagrei. We measured the percent ground cover of Sesuvium and abundance of Achyra on 11 islands with lizards present and 21 islands without lizards annually for 10 consecutive years...
October 2016: Ecology
https://www.readbyqxmd.com/read/27843276/new-visual-prostate-symptom-score-versus-international-prostate-symptom-score-in-men-with-lower-urinary-tract-symptoms-a-prospective-comparision-in-indian-rural-population
#17
Ashutosh Roy, Amandeep Singh, Darshan Singh Sidhu, R P Jindal, Mishi Malhotra, Haramritpal Kaur
INTRODUCTION: Benign prostrate hyperplasia (BPH) is a leading source of healthcare problem in aging men around the world including India. Both International Prostate Symptom Score (IPSS) and New Visual Prostate Symptom Score (VPSS) are used to assess the lower urinary tracts symptoms (LUTSs) in men. The present study was planned to compare these two scores, IPSS and VPSS in Indian rural men prospectively and their efficacy was compared with urodynamic evaluation of the patients. MATERIALS AND METHODS: With Institutional Ethical Committee approval, this study was conducted on 100 patients having LUTS and BPH after obtaining written informed consent...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27736221/lead-poisoning-due-to-lead-pellet-ingestion-in-griffon-vultures-gyps-fulvus-from-the-iberian-peninsula
#18
Manuela A Carneiro Dvm, Paula A Oliveira, Ricardo Brandão, Olga Nicolas Francisco, Roser Velarde, Santiago Lavín, Bruno Colaço
Avian scavengers that typically include game birds and mammals in their diets are at risk of lead poisoning from ingestion of carcasses with fragmented or residual lead ammunition that is used in hunting. Thus, lead may be one of the threats that the griffon vulture ( Gyps fulvus ) faces in the Iberian Peninsula and particularly in Portugal, where their conservation status is considered to be near-threatened. This is the first report that details 3 cases of lead poisoning, associated with the ingestion of lead shot, in adult female griffon vultures found in the Iberian Peninsula...
September 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/27703649/ct-simulation-to-evaluate-of-pelvic-lymph-node-coverage-in-conventional-radiotherapy-fields-based-on-bone-and-vessels-landmarks-in-prostate-cancer-patients
#19
Amir Shahram Yousefi Kashi, Samira Khaledi, Mohammad Houshyari
BACKGROUND: Radiotherapy is the gold standard for treatment of prostrate cancer as it can cover an adequate area of tissues at risk for metastasis. OBJECTIVES: We evaluated the Pelvic lymph node coverage of conventional radiotherapy fields based on bone and vessels landmarks using computed tomography (CT) simulation in patients with prostate cancer referred to Shohada-e-Tajrish hospital. PATIENTS AND METHODS: In this cross sectional study, 40 patients with prostate cancer at the Stage T1c to T3b were studied...
June 2016: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27687897/knowledge-and-practice-of-prostate-cancer-screening-among-general-practitioners-in-malaysia-a-cross-sectional-study
#20
Abdul Malik Tun Firzara, Chirk Jenn Ng
OBJECTIVE: Screening for prostate cancer remains controversial. General practitioners (GPs) play an important role in assisting men to make an informed decision on prostate cancer screening. The aim of this study was to determine the knowledge and practice of prostate cancer screening among private GPs in Malaysia. DESIGN: A cross-sectional study. SETTING: Private general practices in Selangor, Malaysia. PARTICIPANTS: 311 randomly selected full-time private GPs were recruited between September 2013 and January 2014...
2016: BMJ Open
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