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https://www.readbyqxmd.com/read/29222026/transcriptome-analysis-provides-insights-into-the-immune-responsive-pathways-and-genes-in-the-head-kidney-of-tiger-grouper-epinephelus-fuscoguttatus-fed-with-spatholobus-suberectus-phellodendron-amurense-or-eclipta-prostrata
#1
Yan Cai, Shifeng Wang, Weiliang Guo, Zhenyu Xie, Yu Zheng, Zhenjie Cao, Yongcan Zhou
The tiger grouper, Epinephelus fuscoguttatus, is an economically important fish in Southeast Asia but has been plagued by several diseases. Spatholobus suberectus (S), Phellodendron amurense (P), and Eclipta prostrate (E) are three commonly used Chinese medicinal herbs. Although previous pharmacological and clinical studies indicated that S, P, and E possess a variety of beneficial functions in mammals, little is known about their functions in farmed fish and the underlying molecular mechanism of their actions...
December 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29157279/coinfection-with-haemophilus-parasuis-serovar-4-increases-the-virulence-of-porcine-circovirus-type-2-in-piglets
#2
Shuqing Liu, Wentao Li, Yang Wang, Changqin Gu, Xiaoli Liu, Catherine Charreyre, Shenxian Fan, Qigai He
BACKGROUND: Postweaning multisystemic wasting syndrome (PMWS) is an emerging disease in swine. Pigs with PMWS are often infected with a variety of other pathogens, including bacteria, viruses and mycoplasm, in addition to porcine circovirus type 2 (PCV2). PCV2 and Haemophilus parasuis serovar 4 (HPS4) coinfection remain epidemic in China. METHODS: Here we report construction of a three-week-old naturally farrowed, colostrum-deprived (NFCD) piglet's infection model and demonstrate that PCV2-infected piglets with the HPS4 coinfection increased the virulence of PCV2 and these pathogens interact acquired PMWS...
November 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/29109817/diagnosis-of-the-diatom-community-upon-biofilm-development-on-stainless-steels-in-natural-freshwater
#3
Caroline Richard, Smita Mitbavkar, Jessem Landoulsi
This paper reports the development of biofilms on stainless steels (SS) upon exposure in a natural freshwater ecosystem for about six months and focuses on the composition of diatom populations. By using environmental scanning electron microscopy (ESEM) technique, we provide a detailed description regarding diatom identification at species level as well as their main characteristics, including type, morphology, ability to form colony, and motility. Results reveal the presence of both prostrate (initial colonizers) and stalked (late colonizers) forms...
2017: Scanning
https://www.readbyqxmd.com/read/29107268/whom-to-biopsy-prediagnostic-risk-stratification-with-biomarkers-nomograms-and-risk-calculators
#4
REVIEW
Stacy Loeb, Hasan Dani
This article describes markers used for prostate biopsy decisions, including prostrate-specific antigen (PSA), free PSA, the prostate health index, 4Kscore, PCA3, and ConfirmMDx. It also summarizes the use of nomograms combining multiple variables for prostate cancer detection.
November 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29102724/synthesis-of-benzo-d-imidazo-2-1-b-thiazole-chalcone-conjugates-as-microtubule-targeting-and-apoptosis-inducing-agents
#5
Faria Sultana, Srinivasa Reddy Bonam, V Ganga Reddy, V Lakshma Nayak, Ravikumar Akunuri, Sunitha Rani Routhu, Abdullah Alarifi, M Sampath Kumar Halmuthur, Ahmed Kamal
A series of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates (5a-aa) were designed, synthesized and evaluated for their cytotoxic potency against a panel of human cancer cell lines like lung (A-549), breast (MDA MB-231), prostrate (DU-145) and colon cancer (HT-29). Preliminary results revealed that some of these conjugates like 5d and 5u exhibited significant antiproliferative effect against human breast cancer (MDA MB-231) with IC50 values of 1.3 and 1.2 µM respectively. To investigate the mechanistic aspects underlying the activity, the detailed biological studies of these promising conjugates (5d and 5u) were carried out on the MDA MB-231 cancer cells...
November 2, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29080425/comparative-transcriptome-analysis-provides-new-insights-into-erect-and-prostrate-growth-in-bermudagrass-cynodon-dactylon-l
#6
Bing Zhang, Xiaolin Xiao, Junqin Zong, Jingbo Chen, Jianjian Li, Hailin Guo, Jianxiu Liu
Bermudagrass (Cynodon dactylon L.) is a prominent warm-season turf and forage grass species with multiple applications. In most C. dactylon cultivars and accessions, erect-growing stems (shoot) and prostrate-growing stems (stolon) often coexist. These two types of stems are both formed through tillering but grow in two directions with different tiller angles. Elucidating the mechanism of tiller angle regulation in bermudagrass could provide important clues to breed cultivars with different plant architectural features for diverse usage...
October 21, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29023514/prostate-cancer-screening-knowledge-attitudes-and-practices-in-a-sample-of-men-in-italy-a-survey
#7
Marianna Morlando, Concetta Paola Pelullo, Gabriella Di Giuseppe
BACKGROUND: The aim of this study was to evaluate the knowledge, attitudes and behaviors towards prostate cancer and its prevention. METHODS: A cross-sectional survey was conducted on a random sample of 625 fathers of students attending eight public schools. The self-administered questionnaire included questions on: socio-demographic characteristics, personal and familiar medical history of prostate cancer, knowledge about prostate cancer and the prostate-specific antigen (PSA) test, perception of risk towards prostate cancer, perception of the benefits of having a PSA-test, willingness to receive the PSA-test and sources of and needs of information regarding prostate cancer and the PSA-test...
2017: PloS One
https://www.readbyqxmd.com/read/29022249/common-subcluster-mining-in-microarray-data-for-molecular-biomarker-discovery
#8
Arnab Sadhu, Balaram Bhattacharyya
Molecular biomarkers can be potential facilitators for detection of cancer at early stage which is otherwise difficult through conventional biomarkers. Gene expression data from microarray experiments on both normal and diseased cell samples provide enormous scope to explore genetic relations of disease using computational techniques. Varied patterns of expressions of thousands of genes at different cell conditions along with inherent experimental error make the task of isolating disease related genes challenging...
October 11, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28972425/lord-nelson-s-1758-1805-left-eye
#9
William Pryse-Phillips
Following the loss of his right eye at Calvi in 1794, Lord Nelson suffered increasing left-sided visual loss, here considered most likely to have been due to the ocular inflammatory condition 'sympathetic ophthalmia'. It is also argued that his succeeding episodes of violent headaches with nausea and prostration, and possible depigmentation of hair, reflected the development of an uveomeningoencephalitic syndrome akin to that of Vogt-Koyanagi-Harada disease, which is best regarded as the same condition with a different aetiology...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/28819727/abiraterone-acetate-a-review-in-metastatic-castration-resistant-prostrate-cancer
#10
Lesley J Scott
Oral abiraterone acetate (Zytiga(®)) is a selective inhibitor of CYP17 and thereby inhibits androgen biosynthesis, with androgen signalling crucial in the progression from primary to metastatic prostate cancer (PC) and subsequently, in the development of metastatic castration-resistant PC (mCRPC). In large phase 3 trials and in the clinical practice setting, oral abiraterone acetate in combination with prednisone was an effective treatment and had an acceptable, manageable tolerability and safety profile in chemotherapy-naive and docetaxel-experienced men with mCRPC...
September 2017: Drugs
https://www.readbyqxmd.com/read/28806326/recurrent-vestibular-migraine-vertigo-attacks-associated-with-the-development-of-profound-bilateral-vestibulopathy-a-case-series
#11
Jacob L Wester, Akira Ishiyama, Gail Ishiyama
BACKGROUND: Bilateral vestibulopathy (BVP) is a debilitating condition characterized by gait ataxia, oscillopsia, and imbalance. OBJECTIVE: Case series of patients with migraine-linked vertigo spells and profound BVP. PATIENT 1:: A 69-year-old man presented with a history of recurrent severe vertigo spells lasting up to 3 days in duration associated with prostrating migraine headaches starting at age 60. His symptoms were misdiagnosed as an anxiety syndrome. At age 68, electronystagmography (ENG) revealed bilaterally absent caloric responses and complete BVP...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28768513/clinical-and-laboratory-predictors-of-death-in-african-children-with-features-of-severe-malaria-a-systematic-review-and-meta-analysis
#12
Paulina Sypniewska, Jose F Duda, Isabella Locatelli, Clotilde Rambaud Althaus, Fabrice Althaus, Blaise Genton
BACKGROUND: The criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review and meta-analysis. METHOD: Electronic databases (Medline, Embase, Cochrane Database of Systematic Reviews, Thomson Reuters Web of Knowledge) were searched to identify publications including African children with severe malaria. PRISMA guidelines were followed...
August 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28691256/clinical-usefulness-of-mlcs-in-robotic-radiosurgery-systems-for-prostate-sbrt
#13
Masashi Tomida, Takeshi Kamomae, Junji Suzuki, Yoichi Ohashi, Yoshiyuki Itoh, Hiroshi Oguchi, Takahito Okuda
Stereotactic body radiation therapy (SBRT) using recently introduced multileaf collimators (MLC) is preferred over circular collimators in the treatment of localized prostate cancer. The objective of this study was to assess the clinical usefulness of MLCs in prostate SBRT by comparing the effectiveness of treatment plans using fixed collimators, variable collimators, and MLCs and by ensuring delivery quality assurance (DQA) for each. For each patient who underwent conventional radiation therapy for localized prostate cancer, mock SBRT plans were created using a fixed collimator, a variable collimator, and an MLC...
July 10, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28687087/a-rare-case-of-malignant-solitary-fibrous-tumor-in-prostate-with-review-of-the-literature
#14
Andrea Ronchi, Elvira La Mantia, Vincenzo Gigantino, Sisto Perdonà, Marco De Sio, Gaetano Facchini, Renato Franco, Annarosaria De Chiara
BACKGROUND: Solitary fibrous tumor is an uncommon soft tissue neoplasm with intermediate biological behavior, which rarely metastasizes. Malignant solitary fibrous tumor, although not clearly defined, is rarely described in the prostate. The present case is characterized by some peculiarities if compared with previously reported cases of prostatic malignant solitary fibrous tumor. Firstly, it does not show a homogeneous morphology: part of the neoplasm (about 50%) showed the features of a conventional solitary fibrous tumor, while the remaining part showed the features of a malignant solitary fibrous tumor...
July 7, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28634089/wedelolactone-a-plant-coumarin-prevents-vascular-smooth-muscle-cell-proliferation-and-injury-induced-neointimal-hyperplasia-through-akt-and-ampk-signaling
#15
Lu Peng, Xuefeng Huang, Xin Jin, Zuo Jing, Lichao Yang, Yu Zhou, Jie Ren, Yun Zhao
Wedelolactone (WDL) is a natural compound derived from Chinese herbal medicine Eclipta prostrate L, and has been reported to exhibit various effects potentially beneficial for human health. However, the possible preventive effects of WDL toward vascular remodeling and mechanisms involved have not been investigated to date. In this study, we investigated the effects of WDL on proliferation induced by platelet-derived growth factor (PDGF) in primary rat aortic smooth muscle cells (VSMCs) and on neointimal hyperplasia resulted from balloon injury in rats...
June 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28619512/part-1-functions-as-a-competitive-endogenous-rna-for-promoting-tumor-progression-by-sponging-mir-143-in-colorectal-cancer
#16
Yongbo Hu, Zhen Ma, Yiming He, Wei Liu, Yu Su, Zongbin Tang
LncRNAs were altered in several cancers and played a crucial role in various biological activities and progressions of different diseases, including proliferation, chemical resistance, and metastasis. In the present study, we revealed that prostrate androgen-regulated transcript-1 (PART-1) was highly expressed in colorectal cancer cells and tissues, and knockdown of PART-1 suppressed cell proliferation and metastasis, both in vitro and in vivo. In addition, PART-1 functioned as a ceRNA of DNMT3A, by sponging miR-143...
August 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28600722/genetic-dissection-of-plant-growth-habit-in-chickpea
#17
Hari D Upadhyaya, Deepak Bajaj, Rishi Srivastava, Anurag Daware, Udita Basu, Shailesh Tripathi, Chellapilla Bharadwaj, Akhilesh K Tyagi, Swarup K Parida
A combinatorial genomics-assisted breeding strategy encompassing association analysis, genetic mapping and expression profiling is found most promising for quantitative dissection of complex traits in crop plants. The present study employed GWAS (genome-wide association study) using 24,405 SNPs (single nucleotide polymorphisms) obtained with genotyping-by-sequencing (GBS) of 92 sequenced desi and kabuli accessions of chickpea. This identified eight significant genomic loci associated with erect (E)/semi-erect (SE) vs...
June 9, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28567623/molecular-and-functional-characterization-of-myxobacteria-isolated-from-soil-in-india
#18
Shiv Kumar, Arun Kumar Yadav, Priyanka Chambel, Ramandeep Kaur
This study reports the isolation of myxobacteria from soil collected from plains in north India. Based on the morphology and 16S rDNA sequence, the isolated myxobacteria were identified as Corallococcus sp., Pyxidicoccus sp., Myxococcus sp., Cystobacter sp. and Archangium sp. The myxobacteria were functionally characterized to assess their ability to produce antibacterial and anticancer metabolites. The isolates were found to be functionally versatile as they produced extracellular bioactive molecules that exhibited high frequency of activities against Bacillus cereus, Mycobacterium smegmatis, Enterobacter cloacae and Pseudomonas syringae...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28533614/the-effect-of-bridge-exercise-method-on-the-strength-of-rectus-abdominis-muscle-and-the-muscle-activity-of-paraspinal-muscles-while-doing-treadmill-walking-with-high-heels
#19
Taewook Kang, Jaeseok Lee, Junghoon Seo, Dongwook Han
[Purpose] The purpose of this research is to investigate the effect of the method of bridge exercise on the change of rectus abdominis muscle and the muscle activity of paraspinal muscles while doing treadmill walking with high heels. [Subjects and Methods] The subjects of this research are healthy female students consisting of 10 persons performing bridge exercises in a supine group, 10 persons performing bridge exercises in a prone group, and 10 persons in a control group while in S university in Busan. Bridge exercise in supine position is performed in hook lying position...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28499625/range-of-motion-simulation-of-hip-joint-movement-during-salat-activity
#20
J Jamari, Iwan Budiwan Anwar, Eko Saputra, Emile van der Heide
BACKGROUND: Impingement of an artificial hip joint because of limited range of motion (RoM) during human activity is one of the main sources of hip joint failure. The aim of this article is to simulate the RoMs of hip joints during salat, the practice of formal worship in Islam. METHODS: Salat consists of several stages which can be represented with a cycle (raka'ah). Every raka'ah consists of standing, bowing (ruku'), straightening up (i'tidal), transition of standing toward prostrating, prostrating (sujud), and sitting...
September 2017: Journal of Arthroplasty
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