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Manuela A Carneiro Dvm, Paula A Oliveira, Ricardo Brandão, Olga Nicolas Francisco, Roser Velarde, Santiago Lavín, Bruno Colaço
Avian scavengers that typically include game birds and mammals in their diets are at risk of lead poisoning from ingestion of carcasses with fragmented or residual lead ammunition that is used in hunting. Thus, lead may be one of the threats that the griffon vulture ( Gyps fulvus ) faces in the Iberian Peninsula and particularly in Portugal, where their conservation status is considered to be near-threatened. This is the first report that details 3 cases of lead poisoning, associated with the ingestion of lead shot, in adult female griffon vultures found in the Iberian Peninsula...
September 2016: Journal of Avian Medicine and Surgery
Amir Shahram Yousefi Kashi, Samira Khaledi, Mohammad Houshyari
BACKGROUND: Radiotherapy is the gold standard for treatment of prostrate cancer as it can cover an adequate area of tissues at risk for metastasis. OBJECTIVES: We evaluated the Pelvic lymph node coverage of conventional radiotherapy fields based on bone and vessels landmarks using computed tomography (CT) simulation in patients with prostate cancer referred to Shohada-e-Tajrish hospital. PATIENTS AND METHODS: In this cross sectional study, 40 patients with prostate cancer at the Stage T1c to T3b were studied...
June 2016: Iranian Journal of Cancer Prevention
Abdul Malik Tun Firzara, Chirk Jenn Ng
OBJECTIVE: Screening for prostate cancer remains controversial. General practitioners (GPs) play an important role in assisting men to make an informed decision on prostate cancer screening. The aim of this study was to determine the knowledge and practice of prostate cancer screening among private GPs in Malaysia. DESIGN: A cross-sectional study. SETTING: Private general practices in Selangor, Malaysia. PARTICIPANTS: 311 randomly selected full-time private GPs were recruited between September 2013 and January 2014...
2016: BMJ Open
T Hoang Nguyen Vo, Ngan Tran, Dat Nguyen, Ly Le
Herbal medicines have become strongly preferred treatment to reduce the negative impacts of diabetes mellitus (DM) and its severe complications due to lesser side effects and low cost. Recently, strong anti-hyperglycemic effect of Euphorbia thymifolia Linn. (E. thymifolia) on mice models has reported but the action mechanism of its bioactive compounds has remained unknown. This study aimed to evaluate molecular interactions existing between various bioactive compounds in E. thymifolia and targeted proteins related to Type 2 DM...
2016: SpringerPlus
Johne Souza Coelho, Edna Aoba Yassui Ishikawa, Paulo Roberto Silva Garcez Dos Santos, Pedro Pereira de Oliveira Pardal
BACKGROUND: Scorpionism is a serious public health problem in Brazil. Although cases of envenomation by scorpions are frequent in Brazil, Tityus silvestris - found throughout the Amazon region - is considered of minor medical significance and with only a few descriptions in the literature. This article aims to describe for the first time the epidemiological characteristics and clinical manifestations of scorpion stings by T. silvestris that occurred in eastern Brazilian Amazon. METHODS: A prospective and observational study was carried out on 13 confirmed cases of T...
2016: Journal of Venomous Animals and Toxins Including Tropical Diseases
Debabrata Chowdhury, Dinesh Kumar, Pranjal Sarma, Anjana Devi Tangutur, Manika Pal Bhadra
Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. However, regulation and function of these proteins in different cells, tissues and in various diseases is different as evidenced by expression of these proteins which is found to be reduced in heart diseases, kidney diseases, lung disease, Crohn's disease and ulcerative colitis but this protein is highly expressed in diverse cancer diseases. The mechanism by which this protein acts at the molecular level in different subcellular localizations or in different cells or tissues in different conditions (diseases or normal) has remained poorly understood...
August 24, 2016: Current Drug Targets
Yohannes Demissie, Tsige Ketema
BACKGROUND: Malaria is still a major health problem in some parts of the world. Plasmodium falciparum is the common pathogenic parasite and is responsible for majority of malaria associated deaths. Recently the other benign parasite, P. vivax, is reported to cause life threatening severe malaria complications. Thus, this study was aimed to assess incidence of severe malaria symptoms caused by P. vivax parasite in some malaria endemic areas of Ethiopia. MATERIALS AND METHODS: Presumptive malaria patients (all age groups) seeking medication at the selected health facilities in Mendi town, Northwest Ethiopia, were recruited for the study...
2016: BMC Infectious Diseases
Nobuhiro Uwa, Tomonori Terada, Takeshi Mohri, Yoshitane Tsukamoto, Hiroyuki Futani, Yusuke Demizu, Tomoaki Okimoto, Masafumi Sakagami
We herein report the case of a patient presenting with myxofibrosarcoma (MFS) who underwent treatment with surgery, proton beam therapy (PBT), and pazopanib. A 64-year-old male was diagnosed with MFS, which ranged from the posterior neck to the shoulder. Surgery was performed as an initial treatment; however, the primary tumor recurred 83 months after the initial treatment. We, therefore, administered PBT. Although most of the recurrent tumor disappeared after PBT, multiple lung metastases were identified 3 months after the completion of PBT...
August 11, 2016: Auris, Nasus, Larynx
Eunsook Park, Mee-Young Lee, Woo-Young Jeon, Nari Lee, Chang-Seob Seo, Hyeun-Kyoo Shin
Yongdamsagan-tang, a traditional herbal formula, is used widely for the treatment of inflammation and viral diseases. In this study, we investigated whether Yongdamsagan-tang water extract (YSTE) affects testosterone propionate- (TP-) induced benign prostatic hyperplasia (BPH) in a rat model. To induce BPH, rats were injected subcutaneously with 10 mg/kg of TP every day. YSTE was administrated daily by oral gavage at doses of 200 and 500 mg/kg along with the TP injection. After 4 weeks, prostates were collected, weighed, and analyzed...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
D Y Sumner, A D Jungblut, I Hawes, D T Andersen, T J Mackey, K Wall
Microbial pinnacles in ice-covered Lake Vanda, McMurdo Dry Valleys, Antarctica, extend from the base of the ice to more than 50 m water depth. The distribution of microbial communities, their photosynthetic potential, and pinnacle morphology affects the local accumulation of biomass, which in turn shapes pinnacle morphology. This feedback, plus environmental stability, promotes the growth of elaborate microbial structures. In Lake Vanda, all mats sampled from greater than 10 m water depth contained pinnacles with a gradation in size from <1-mm-tall tufts to pinnacles that were centimeters tall...
November 2016: Geobiology
Mehmet Ceyhan, Yasemin Ozsurekci, Nezahat Gürler, Eda Karadag Oncel, Yıldız Camcioglu, Nuran Salman, Melda Celik, Melike Keser Emiroglu, Fatih Akin, Hasan Tezer, Aslinur Ozkaya Parlakay, Nilden Tuygun, Diyar Tamburaci, Ener Cagri Dinleyici, Adem Karbuz, Ünal Uluca, Emre Alhan, Ümmühan Çay, Zafer Kurugol, Nevin Hatipoğlu, Rengin Şiraneci, Tolga İnce, Gülnar Sensoy, Nursen Belet, Enes Coskun, Fatih Yilmaz, Mustafa Hacimustafaoglu, Solmaz Celebi, Ümit Celik, Metehan Ozen, Aybüke Akaslan, İlker Devrim, Necdet Kuyucu, Fatmanur Öz, Sefika Elmas Bozdemir, Ahu Kara
This is an observational epidemiological study to describe causes of bacterial meningitis among persons between 1 month and 18 years of age who are hospitalized with suspected bacterial meningitis in 7 Turkish regions. covering 32% of the entire population of Turkey. We present here the results from 2013 and 2014. A clinical case with meningitis was defined according to followings: any sign of meningitis including fever, vomiting, headache, and meningeal irritation in children above one year of age and fever without any documented source, impaired consciousness, prostration and seizures in those <1 year of age...
July 25, 2016: Human Vaccines & Immunotherapeutics
M Seilmaier, W Guggemos, A Wieser, V Fingerle, L Balzer, T Fenzl, M Hoch, U von Both, H U Schmidt, C M Wendtner, E Strobel
Background | Relapsing fever is divided into tick borne relapsing fever (TBRF) and louse borne relapsing fever (LBRF). This report describes 25 refugees from East Africa who were diagnosed to suffer from LBRF within a period of 6 month only at a single hospital in Munich / Germany. Material & Methods | The aim was to point out common clinical features as well as laboratory findings and clinical symptoms before and after initiation of treatment in 25 patients with louse borne relapsing fever (LBRF) who were diagnosed and treated at Klinikum München Schwabing from August 2015 to January 2016...
July 2016: Deutsche Medizinische Wochenschrift
Sonia Mahey, Rakesh Kumar, Rohit Arora, Jyoti Mahajan, Saroj Arora, Renu Bhardwaj, Ashwani Kumar Thukral
The present study investigates the anti-proliferative and apoptosis inducing mechanism of CoCl2·6H2O in PC-3 cancer cell line. Preliminary, three different forms of cobalt i.e., cobaltous (CoCl2·6H2O), macro-Co(II,III) oxide and nano-Co(II,III) oxide were screened for antiproliferative activity in PC-3 cell line. The CoCl2·6H2O being the most effective antiproliferative agent, hence it was further tested against lung (A549), prostrate (PC-3) and brain (IMR-32) cell lines. Human embryonic kidney cell line (293T) was used as a normal cell line to compare the toxicity of CoCl2·6H2O...
2016: SpringerPlus
Víctor Manuel Ramos Frausto, José María De La Roca Chiapas, Nancy Yadira Días García, Juana Graciela Luna Camargo, Mariazel García Rocha
INTRODUCTION: The Pressure Ulcer Scale for Healing (PUSH) represent a serious problem around the world since they have important consequences, personal and economic, this making it a public problem health. The PUSH are a challenge for professionals nursing at all levels of care. OBJECTVE: Identify the frequency of Pressure Ulcer Scale for Healing in patients hospitalized in coronary and intensive unit care of a high specialty hospital. MATERIAL AND METHODS: A descriptive, observational, prospective, and cross-sectional study...
April 2016: Revista de Enfermería
S Fernandez-Menendez, J M Gonzalez-Gonzalez, V Alvarez-Antuna, J Bobes
INTRODUCTION: Ferdinand VI was king of Spain from 1746 until 1759. His last year of reign is known as the year without a king. Over this year the king suffered a rapidly progressive deterioration of his mental health status. The clinical condition has been always attributed to a pure psychiatric disorder, generally a bipolar disorder. DEVELOPMENT: We review the sources of information in the Spanish archives and libraries, in order to find clinical information about the illness suffered by the king...
June 1, 2016: Revista de Neurologia
Patrick J Sabourin, Christina L Kobs, Seth T Gibbs, Peter Hong, Claire M Matthews, Kristen M Patton, Carol L Sabourin, Edgar J Wakayama
Potassium cyanide (KCN) is an inhibitor of cytochrome C oxidase causing rapid death due to hypoxia. A well-characterized model of oral KCN intoxication is needed to test new therapeutics under the Food and Drug Administration Animal Rule. Clinical signs, plasma pH and lactate concentrations, biomarkers, histopathology, and cyanide and thiocyanate toxicokinetics were used to characterize the pathology of KCN intoxication in adult and juvenile mice. The acute oral LD50s were determined to be 11.8, 11.0, 10.9, and 9...
September 2016: International Journal of Toxicology
Scott N Williamson, Isabel C Barrio, David S Hik, John A Gamon
Arctic warming is resulting in reduced snow cover and increased shrub growth, both of which have been associated with altered land surface-atmospheric feedback processes involving sensible heat flux, ground heat flux and biogeochemical cycling. Using field measurements, we show that two common Arctic shrub species (Betula glandulosa and Salix pulchra), which are largely responsible for shrub encroachment in tundra, differed markedly in albedo and that albedo of both species increased as growing season progressed when measured at their altitudinal limit...
May 9, 2016: Global Change Biology
Min-Ho Han, Won Sup Lee, Arulkumar Nagappan, Hye Jung Kim, Cheol Park, Gi-Young Kim, Sang Hoon Hong, Nam Deuk Kim, Gonsup Kim, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Choi
The Korean prostrate spurge Euphorbia supina (Euphorbiaceae family) has been used as a folk medicine in Korea against a variety of ailments such as bronchitis, hemorrhage, jaundice and multiple gastrointestinal diseases. Polyphenols from Korean E. supina (PES) which include quercetin and kaempferol derivatives have anticancer properties. Hence, we investigated the anticancer effects of PES on U937 human leukemic cells. Firstly, PES significantly inhibited the proliferation of U937 cells in a dose-dependent manner...
July 2016: Oncology Reports
Oliver J Hickman, Richard A Smith, Prokar Dasgupta, Sudha Narayana Rao, Soumya Nayak, Shubha Sreenivasan, Annapurna Vyakarnam, Christine Galustian
BACKGROUND: WFDC1/Prostate stromal 20 (ps20) is a small secreted protein highly expressed within the prostate stroma. WFDC1/ps20 expression is frequently downregulated or lost in prostate cancer (PCa) and ps20 has demonstrated growth-suppressive functions in numerous tumour model systems, although the mechanisms of this phenomenon are not understood. METHODS: Ps20 was cloned and overexpressed in DU145, PC3, LNCaP and WPMY-1 cells. Cellular growth, cell cycle and apoptosis were characterised...
May 24, 2016: British Journal of Cancer
Michael B Ashworth, Michael J Walsh, Ken C Flower, Martin M Vila-Aiub, Stephen B Powles
Herbicides have been the primary tool for controlling large populations of yield depleting weeds from agro-ecosystems, resulting in the evolution of widespread herbicide resistance. In response, nonherbicidal techniques have been developed which intercept weed seeds at harvest before they enter the soil seed bank. However, the efficiency of these techniques allows an intense selection for any trait that enables weeds to evade collection, with early-flowering ecotypes considered likely to result in early seed shedding...
April 2016: Evolutionary Applications
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