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https://www.readbyqxmd.com/read/28323967/all-cause-mortality-in-patients-with-diabetes-under-treatment-with-dapagliflozin-a-population-based-open-cohort-study-in-thin-database
#1
Konstantinos A Toulis, Brian H Willis, Tom Marshall, Balachadran Kumarendran, Krishna Gokhale, Sandip Ghosh, G Neil Thomas, Kar Keung Cheng, Parth Narendran, Wasim Hanif, Krishnarajah Nirantharakumar
Context: Empagliflozin was found to decrease mortality in patients with type 2 diabetes (T2DM) and a prior cardiovascular (CVD) event. Objectives: To establish whether these benefits can be replicated in a real-world setting, should be expected with the use of dapagliflozin, and apply to T2DM patients at low risk of CVD. Design: General Practice, population-based, retrospective cohort study (January 2013-September 2015). Setting: The Health Improvement Network Database (THIN)...
February 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28318630/sarcopenia-and-its-individual-criteria-are-associated-in-part-with-mortality-among-patients%C3%A2-on-hemodialysis
#2
Piyawan Kittiskulnam, Glenn M Chertow, Juan J Carrero, Cynthia Delgado, George A Kaysen, Kirsten L Johansen
The relative importance of sarcopenia and its individual components as independent predictors of mortality in the dialysis population has not been determined. We estimated whole-body muscle mass using pre-dialysis bioimpedance spectroscopy measurements in 645 ACTIVE/ADIPOSE-enrolled prevalent hemodialysis patients from San Francisco and Atlanta. Low muscle mass was defined as two standard deviations below sex-specific means for young adults from NHANES and indexed to height(2), body weight, body surface area, or body mass index...
March 16, 2017: Kidney International
https://www.readbyqxmd.com/read/28293304/the-burden-of-diabetes-and-hyperglycemia-in-brazil-past-and-present-findings-from-the-global-burden-of-disease-study-2015
#3
Bruce Bartholow Duncan, Maria Inês Schmidt, Ewerton Cousin, Maziar Moradi-Lakeh, Valéria Maria de Azeredo Passos, Elisabeth Barboza França, Fátima Marinho, Ali H Mokdad
BACKGROUND: Diabetes, hyperglycemia, and their complications are a growing problem in Brazil. However, no comprehensive picture of this disease burden has yet been presented to date. METHODS: We used Global Burden of Disease 2015 data to characterize diabetes prevalence, incidence and risk factors from 1990 to 2015 in Brazil. Additionally, we provide mortality, years of life lost prematurely (YLL), years of life lived with disability (YLD) and disability-adjusted life years (DALYs) lost due to diabetes, as well as similar data for chronic kidney disease (CKD) due to diabetes and, as an overall summary measure, for hyperglycemia, the latter expressed as high fasting plasma glucose (HFPG)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28292345/bmi-and-bmi-changes-to-all-cause-mortality-among-the-elderly-in-beijing-a-20-year-cohort-study
#4
Yun Feng Wang, Zhe Tang, Jin Guo, Li Xin Tao, Long Liu, Hai Bin Li, Di Tian Li, Xiu Hua Guo, Xing Hua Yang
OBJECTIVE: To explore the association between body mass index (BMI) and all-cause mortality among the elderly in Beijing. METHODS: This analysis was based on the Beijing multidimensional longitudinal study of aging (BLSA), which included 2,090 subjects over 55 years old and was followed-up from 1992 to 2012. BMI-mortality curves were drawn to find the optimal BMI range with the lowest mortality. Cox proportional hazard models were used to obtain the hazard ratios (HRs) for BMI and BMI changes in the overall population and in specific stratified populations...
February 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28279654/bloodstream-amyloid-beta-1-40-peptide-cognition-and-outcomes-in-heart-failure
#5
Antoni Bayes-Genis, Jaume Barallat, Marta de Antonio, Mar Domingo, Elisabet Zamora, Joan Vila, Isaac Subirana, Paloma Gastelurrutia, M Cruz Pastor, James L Januzzi, Josep Lupón
INTRODUCTION AND OBJECTIVES: In the brain, amyloid-beta generation participates in the pathophysiology of cognitive disorders; in the bloodstream, the role of amyloid-beta is uncertain but may be linked to sterile inflammation and senescence. We explored the relationship between blood levels of amyloid-beta 1-40 peptide (Aβ40), cognition, and mortality (all-cause, cardiovascular, and heart failure [HF]-related) in ambulatory patients with HF. METHODS: Bloodstream Aβ40 was measured in 939 consecutive patients with HF...
March 6, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28270838/clinical-and-hemodynamic-profiles-of-elderly-patients-with-pulmonary-arterial-hypertension-a-single-center-prospective-study
#6
Ebru Ozpelit, Bahri Akdeniz, Dilek Sezgin, Can Sevinc, Kemal Can Tertemiz, Mehmet Emre Ozpelit, Mustafa Baris, Nezihi Baris
BACKGROUNDS: Pulmonary arterial hypertension (PAH) was previously considered an illness that affects mostly the young, but now it is also increasingly recognized in the elderly. The aim of this study was to compare the features of elderly versus younger patients diagnosed with PAH, and to define the prognostic factors which affect their long-term survival. METHODS: In this prospective, single center study, the clinical, echocardiographic, hemodynamic characteristics, and the outcomes of younger (18-65 years) and elderly (≥ 65 years) patients with definitive diagnosis of precapillary PAH were compared...
January 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28265965/hypophosphatemia-nutritional-status-body-composition-and-mortality-in-hemodialysis-patients
#7
Cristina Garagarza, Ana Valente, Cristina Caetano, Telma Oliveira, Pedro Ponce, Ana Paula Silva
PURPOSE: The aim of the present study was to investigate the relationship between serum phosphate levels, clinical parameters, body composition, and mortality. METHODS: Multicenter longitudinal observational study of a cohort of 3552 patients in hemodialysis (HD) from 34 Nephrocare dialysis units in Portugal with 24 months of follow-up. Patients were divided into three groups depending on their serum phosphorus (<3.5; 3.5-5.5; >5.5 mg/dL). Statistical tests were performed with SPSS, version 20...
March 6, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28261905/sarcopenia-based-on-the-asian-working-group-for-sarcopenia-criteria-and-all-cause-mortality-risk-in-older-japanese-adults
#8
Atsumu Yuki, Fujiko Ando, Rei Otsuka, Hiroshi Shimokata
AIM: The association between sarcopenia diagnosed according to the criteria of the Asian Working Group for Sarcopenia and increased mortality risk is currently unknown. The present study assessed the longitudinal relationship between sarcopenia and mortality risk in an elderly Japanese population. METHODS: Participants were 720 community-dwelling Japanese individuals aged 65-79 years at baseline (November 1997 to April 2000). The participants were followed from baseline to 31 December 2014 (mean duration 11...
March 5, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28258498/mortality-risk-among-screened-subjects-of-the-specific-health-check-and-guidance-program-in-japan-2008-2012
#9
Kunitoshi Iseki, Koichi Asahi, Kunihiro Yamagata, Shouichi Fujimoto, Kazuhiko Tsuruya, Ichiei Narita, Tsuneo Konta, Masato Kasahara, Yugo Shibagaki, Hisako Yoshida, Toshiki Moriyama, Masahide Kondo, Chiho Iseki, Tsuyoshi Watanabe
BACKGROUND: In Japan, the Specific Health Check and Guidance (Tokutei-Kenshin) has started in 2008. However, the relationship between the baseline characteristics and mortality has not been examined. METHODS: Subjects were those who participated at the 2008 Tokutei-Kenshin in six districts with baseline data of serum creatinine. Using National database of death certificate from 2008 to 2012, we identified those who might have died and confirmed further with the collaborations of the regional National Health Insurance agency and public health nurses...
March 3, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28256417/ischemic-stroke-mortality-is-more-strongly-associated-with-anemia-on-admission-than-with-underweight-status
#10
Satoshi Kubo, Naohisa Hosomi, Naoyuki Hara, Shuichiro Neshige, Takahiro Himeno, Shinichi Takeshima, Kazuhiro Takamatsu, Yutaka Shimoe, Taisei Ota, Hirofumi Maruyama, Toshiho Ohtsuki, Masaru Kuriyama, Masayasu Matsumoto
BACKGROUND: Underweight patients have recently been reported as a group with a high risk of poststroke death. Anemia also increases mortality rates in stroke patients. However, the causal associations between body weight and anemia resulting in stroke-related death remain unclear. We examined the association of weight status and hemoglobin levels with 3-month mortality after ischemic stroke. METHODS: The study enrolled all consecutive patients with acute ischemic stroke and no history of stroke admitted to our hospital between January 2010 and December 2013...
February 27, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28256020/left-atrial-anatomy-and-patient-related-factors-associated-with-adverse-outcomes-with-the-watchman-device-a-real-world-experience
#11
Shishir Murarka, Mohamad Lazkani, Soundos Moualla, Divya Ratan Verma, Ashish Pershad
OBJECTIVE: This study sought to identify patient and left atrial morphology specific factors associated with early complications for left atrial appendage occlusion with the Watchman™ (Boston Scientific, Natick, MA) device. BACKGROUND: Oral anticoagulation (OAC) is recommended for patients with atrial fibrillation, however, long-term OAC compliance is poor. In randomized control trials, the Watchman™ device has demonstrated superiority over OAC with warfarin for all cause and cardiovascular mortality and hemorrhagic stroke...
March 2, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28255009/association-between-diabetes-and-1-year-adverse-clinical-outcomes-in-a-multinational-cohort-of-ambulatory-patients-with-chronic-heart-failure-results-from-the-esc-hfa-heart-failure-long-term-registry
#12
Marco Dauriz, Giovanni Targher, Cécile Laroche, Pier Luigi Temporelli, Roberto Ferrari, Stephan Anker, Andrew Coats, Gerasimos Filippatos, Maria Crespo-Leiro, Alexandre Mebazaa, Massimo F Piepoli, Aldo P Maggioni, Luigi Tavazzi
OBJECTIVE: Diabetes mellitus is associated with an increased risk of cardiovascular disease (CVD) and death. Because the prevalence of diabetes is rising worldwide and chronic heart failure (CHF) is becoming increasingly common with the aging population, it is timely to examine the impact of diabetes per se on 1-year adverse outcomes in patients with CHF. RESEARCH DESIGN AND METHODS: We prospectively assessed whether diabetes status independently affected the 1-year risk of all-cause and CVD mortality and first hospitalization for worsening heart failure (HF) in a multinational cohort of 9,428 outpatients with CHF enrolled in the European Society of Cardiology and Heart Failure Association Long-Term Registry...
March 2, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28253241/missing-data-on-body-mass-index-in-a-breast-cancer-register-how-is-it-associated-with-patient-characteristics-and-clinical-outcomes
#13
Sandar Tin Tin, J Mark Elwood, Ross Lawrenson, Ian Campbell
AIM: To assess the completeness of data on body mass index (BMI) in a regional breast cancer register, and its association with patient characteristics and clinical outcomes. METHODS: This analysis used the data from the Waikato Breast Cancer Register and involved all women who were diagnosed with primary breast cancer in the Waikato District Health Board Region between January 2000 and June 2014. Patients with recorded BMI were compared with those with missing data in terms of demographics, disease factors and treatment factors...
March 3, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28252622/-risk-of-death-from-circulatory-diseases-in-a-cohort-of-patients-exposed-to-chronic-radiation
#14
T V Azizova, E S Grigoryeva, N Hunter, M V Pikulina, M B Moseeva
AIM: To assess mortality from circulatory diseases (CD) in a cohort of workers exposed occupationally to chronic radiation in relation to external and internal exposure, by taking into account known non-radiation risk factors (RFs), such as smoking (including smoking index), alcohol consumption, hypertension, and body mass index. SUBJECTS AND METHODS: Mortality from CD (ICD-10: I00 - I99) was studied in a cohort of 22,377 nuclear power plant («Mayak» Production Association) workers exposed occupationally to chronic radiation...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28249867/obesity-paradox-comparison-of-heart-failure-patients-with-and-without-comorbid-diabetes
#15
Kyoung Suk Lee, Debra K Moser, Terry A Lennie, Michele M Pelter, Thomas Nesbitt, Jeffrey A Southard, Kathleen Dracup
BACKGROUND: Diabetes is a common comorbid condition in patients with heart failure and is strongly associated with poor outcomes. Patients with heart failure who have diabetes are more likely to be obese than are those without diabetes. Obesity is positively associated with survival in patients with heart failure, but how comorbid diabetes influences the relationship between obesity and favorable prognosis is unclear. OBJECTIVE: To explore whether the relationship between body mass index and survival differs between patients with heart failure who do or do not have diabetes...
March 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/28243456/is-frailty-a-relevant-concept-in-sle
#16
Patricia P Katz, James Andrews, Jinoos Yazdany, Gabriela Schmajuk, Laura Trupin, Edward Yelin
OBJECTIVE: In geriatric populations, frailty is associated with poor health outcomes, including mortality. Frailty has not been examined in lupus, although components of the phenotype seem relevant. METHODS: Women with lupus (n=152) participated in research visits in 2008-2009. Frailty was assessed by Fried's frailty phenotype criteria: low weight/unintentional weight loss, slow gait (4-m walk using sex and height criteria), weakness (grip strength using gender and body mass index criteria), exhaustion (2 specific questions) and inactivity (from physical activity questionnaire)...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/28242483/classical-rather-than-genetic-risk-factors-account-for-high-cardiovascular-disease-prevalence-in-lithuania-a-cross-sectional-population-study
#17
Neringa Burokienė, Ingrida Domarkienė, Laima Ambrozaitytė, Ingrida Uktverytė, Raimonda Meškienė, Dovilė Karčiauskaitė, Vytautas Kasiulevičius, Virginijus Šapoka, Vaidutis Kučinskas, Zita Aušrelė Kučinskienė
PURPOSE: Cardiovascular disease (CVD) mortality accounts for 54% of all deaths in Lithuania, making it the highest among all of the European Union countries. We evaluated the prevalence of several CVD risk factors, including lifestyle, blood biochemistry and genetic predisposition to determine the reasons behind significantly increased CVD prevalence in Lithuania. MATERIALS AND METHODS: In total 435 volunteers of Lithuanian ethnicity and stable geographic settlement for 3 generations, had their anthropometric, biochemical and behavioural risk factors measured...
February 24, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28242247/recurrent-pregnancy-loss-and-cardiovascular-disease-mortality-in-japanese-women-a-population-based-prospective-cohort-study
#18
Keiko Yamada, Hiroyasu Iso, Renzhe Cui, Akiko Tamakoshi
BACKGROUND: This study aimed to examine the association between recurrent pregnancy loss and the risk of cardiovascular disease mortality. METHODS: We identified 54,652 women who were pregnant during the Japan Collaborative Cohort Study. These women were 40-79 years at the date of cohort entry between 1988 and 1990. Participants received municipal health screening examinations and completed self-administered questionnaires. The cause of death was confirmed by annual or biannual follow-up surveys for a median of 18 years...
February 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28231667/-association-between-body-mass-index-and-both-total-and-cause-specific-mortality-in-china-findings-from-data-through-the-china-kadoorie-biobank
#19
L X Wang, M Y Fan, C Q Yu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, J Lyu, L M Li
Objective: To evaluate the associations between body mass index (BMI) and both total and cause-specific mortality. Methods: After excluding participants with heart disease, stroke, cancer, chronic obstructive pulmonary disease, and diabetes at baseline study, 428 593 participants aged 30-79 in the China Kadoorie Biobank study were chosen for this study. Participants were categorized into 9 groups according to their BMI status. Cox regression analysis was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality on BMI...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28229456/body-mass-index-waist-circumference-and-mortality-in-a-large-multiethnic-postmenopausal-cohort-results-from-the-women-s-health-initiative
#20
Zhao Chen, Yann C Klimentidis, Jennifer W Bea, Kacey C Ernst, Chengcheng Hu, Rebecca Jackson, Cynthia A Thomson
OBJECTIVES: To determine whether the relationship between anthropometric measurements of obesity and mortality varies according to age, race, and ethnicity in older women. DESIGN: Prospective cohort study of multiethnic postmenopausal women. SETTING: Women's Health Initiative (WHI) observational study and clinical trials in 40 clinics. PARTICIPANTS: Postmenopausal women aged 50-79 participating in WHI (N = 161,808). MEASUREMENTS: Baseline height, weight, and waist circumference (WC) were measured, and body mass index (BMI) was calculated based on height and weight...
February 23, 2017: Journal of the American Geriatrics Society
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