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https://www.readbyqxmd.com/read/28727287/weighing-the-risks-morbid-obesity-and-diabetes-are-associated-with-increased-risk-of-death-on-the-liver-transplant-waiting-list
#1
Ani A Kardashian, Jennifer L Dodge, John Roberts, Danielle Brandman
Obesity is a growing problem in liver transplant (LT) candidates, paralleling the U.S. obesity epidemic and increase in LT for nonalcoholic steatohepatitis (NASH). While post-LT survival appears to be similar in obese and non-obese patients, data is scarce regarding risk of waitlist dropout in patients with morbid obesity (BMI≥40 kg/m(2) ). We examined the impact of obesity on waitlist mortality and evaluated predictors of dropout in LT candidates with morbid obesity or NASH METHODS: Competing risk analyses were performed in candidates listed between 3/2002-12/2013 to evaluate predictors of waitlist removal or death...
July 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28725327/prevalence-of-undiagnosed-cardiovascular-risk-factors-in-adults-aged-20-40-a-cross-sectional-study-in-2016-in-jeddah-saudi-arabia
#2
Faisal Saed Alharthi, Jamilah Saad Alrahimi, Abdulrahman Ali Alotaibi, Daniah Ahmed Alhamdi, Bashair Mohammed Ibrahim, Yasmina Aymen Badeeb
BACKGROUND: Cardiovascular diseases (CVDs) are the first leading cause of death worldwide. In Saudi Arabia, CVDs are the major killers with a mortality rate of 46%. CVD risk factors are not exclusive to old populations. Thus, the purpose of this study was to approximately find the prevalence of these risk factors, particularly high blood pressure (HBP), high blood glucose (HBG), obesity, and smoking. METHODS: This cross-sectional was conducted in May 2016 and took place in the Ambulatory Care Center of King Abdulaziz Medical City, Jeddah...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28717816/prospective-associations-of-low-muscle-mass-and-function-with-10-year-falls-risk-incident-fracture-and-mortality-in-community-dwelling-older-adults
#3
S Balogun, T Winzenberg, K Wills, D Scott, G Jones, D Aitken, M L Callisaya
OBJECTIVES: Purpose: To compare the performance of low muscle mass and function with falls risk, incident fracture and mortality over 10 years. METHODS: 1041 participants (50% women; mean age 63±7.5 years) were prospectively followed for 10 years. Falls risk was measured using the Physiological Profile Assessment, fractures were self-reported and mortality was ascertained from the death registry. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28715136/underweight-and-hypoalbuminemia-as-risk-indicators-for-mortality-among-psychiatric-patients-with-medical-comorbidities
#4
Takahiro Haga, Kae Ito, Masahiro Ono, Jiro Maruyama, Mari Iguchi, Hitoe Suzuki, Eiji Hayashi, Kentaro Sakashita, Tomoko Nagao, Shohei Ikemoto, Asuka Okaniwa, Makiko Kitami, Eriko Inuo, Koichiro Tatsumi
AIM: Medical comorbidities are a major cause of death among patients with mental illness. The purpose of this study was to clarify the risk factors for mortality among psychiatric patients with medical comorbidities. METHODS: We retrospectively reviewed the clinical files of patients transferred to Tokyo Metropolitan Matsuzawa Hospital from a psychiatric hospital to treat medical comorbidities during the three-year period from January 2014 to December 2016. We analyzed the clinical differences between the expired and alive patients...
July 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28709946/frailty-and-sarcopenia-do-not-predict-adverse-events-in-an-elderly-population-undergoing-non-complex-primary-elective-surgery-for-degenerative-conditions-of-the-lumbar-spine
#5
Raphaële Charest-Morin, John Street, Honglin Zhang, Taren Roughead, Tamir Ailon, Michael Boyd, Marcel Dvorak, Brian Kwon, Scott Paquette, Nicolas Dea, Charles G Fisher, Alana M Flexman
BACKGROUND CONTEXT: Sarcopenia measured by normalized total psoas area (NTPA) has been shown to predict mortality and adverse events (AE) in numerous surgical populations. The relationship between sarcopenia and postoperative outcomes after surgery for degenerative spine disease (DSD) has not been investigated. PURPOSE: This study aimed to determine the relationships between sarcopenia, frailty and postoperative adverse events in the elderly DSD population. Secondary objectives were to describe the distribution and predictors of NTPA and to determine the relationship between sarcopenia, frailty and length of stay, discharge to a facility and in-hospital mortality...
July 11, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28707322/development-and-validation-of-a-risk-model-for-long-term-mortality-after-percutaneous-coronary-intervention-the-idea-bio-study
#6
Nick van Boven, Ron T van Domburg, Isabella Kardys, Victor A Umans, K Martijn Akkerhuis, Mattie J Lenzen, Marco Valgimigli, Joost Daemen, Felix Zijlstra, Eric Boersma, Robert-Jan van Geuns
OBJECTIVES: We aimed to develop a model to predict long-term mortality after percutaneous coronary intervention (PCI), to aid in selecting patients with sufficient life expectancy to benefit from bioabsorbable scaffolds. BACKGROUND: Clinical trials are currently designed to demonstrate superiority of bioabsorbable scaffolds over metal devices up to 5 years after implantation. METHODS: From 2000 to 2011, 19.532 consecutive patients underwent PCI in a tertiary referral hospital...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28706094/ventilatory-function-as-a-predictor-of-mortality-in-lifelong-non-smokers-evidence-from-large-british-cohort-studies
#7
Ramyani P Gupta, David P Strachan
BACKGROUND: Reduced ventilatory function is an established predictor of all-cause mortality in general population cohorts. We sought to verify this in lifelong non-smokers, among whom confounding by active smoking can be excluded, and investigate associations with circulatory and cancer deaths. METHODS: In UK Biobank, among 149 343 white never-smokers aged 40-69 years at entry, 2401 deaths occurred over a mean of 6.5-year follow-up. In the Health Surveys for England (HSE) 1995, 1996, 2001 and Scottish Health Surveys (SHS) 1998 and 2003 combined, there were 500 deaths among 6579 white never-smokers aged 40-69 years at entry, followed for a mean of 13...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28702259/clinical-effects-cardiovascular-and-renal-outcomes-associated-with-rapid-acting-insulin-analogs-among-individuals-with-type-2-diabetes-a-nation-wide-observational-cohort-study
#8
Ann-Marie Svensson, Mervete Miftaraj, Stefan Franzén, Björn Eliasson
BACKGROUND: Rapid-acting insulin analogs (RAIs) have not been examined for long-term safety in randomized clinical trials. We performed a nationwide longitudinal cohort study among individuals with type 2 diabetes (T2DM) to address cardiovascular safety and mortality among users of lispro, aspart and glulisine insulins. METHODS: We used four national registers, following patients previously not treated with RAI but with continuous use of RAIs in 2005-2014 up to 6...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/28700821/gene-expression-profiling-of-prostate-tissue-identifies-chromatin-regulation-as-a-potential-link-between-obesity-and-lethal-prostate-cancer
#9
Ericka M Ebot, Travis Gerke, David P Labbé, Jennifer A Sinnott, Giorgia Zadra, Jennifer R Rider, Svitlana Tyekucheva, Kathryn M Wilson, Rachel S Kelly, Irene M Shui, Massimo Loda, Philip W Kantoff, Stephen Finn, Matthew G Vander Heiden, Myles Brown, Edward L Giovannucci, Lorelei A Mucci
BACKGROUND: Obese men are at higher risk of advanced prostate cancer and cancer-specific mortality; however, the biology underlying this association remains unclear. This study examined gene expression profiles of prostate tissue to identify biological processes differentially expressed by obesity status and lethal prostate cancer. METHODS: Gene expression profiling was performed on tumor (n = 402) and adjacent normal (n = 200) prostate tissue from participants in 2 prospective cohorts who had been diagnosed with prostate cancer from 1982 to 2005...
July 12, 2017: Cancer
https://www.readbyqxmd.com/read/28700275/guideline-based-statin-eligibility-cancer-events-and-noncardiovascular-mortality-in-the-framingham-heart-study
#10
Amit Pursnani, Joseph M Massaro, Ralph B D'Agostino, Christopher J O'Donnell, Udo Hoffmann
Purpose Cancer and cardiovascular disease share risk factors, and there is some evidence that statins reduce cancer mortality. We sought to determine the accuracy of the 2013 American College of Cardiology/American Heart Association statin eligibility criteria to identify individuals at a higher risk of developing cancer or of dying as a result of cancer or other noncardiovascular causes. Methods We included 2,196 participants (50.5 ± 8.1 years of age; 55% female) who were statin naïve and free of cancer at baseline from the offspring and third-generation cohorts of the community-based longitudinal Framingham Heart Study...
July 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28698231/survival-benefit-of-statin-use-in-ankylosing-spondylitis-a-general-population-based-cohort-study
#11
Amar Oza, Na Lu, Sara R Schoenfeld, Mark C Fisher, Maureen Dubreuil, Sharan K Rai, Yuqing Zhang, Hyon K Choi
OBJECTIVES: Recent studies have shown an increase in both cardiovascular and all-cause mortality in ankylosing spondylitis (AS). We examined the potential survival benefit of statin use in AS within a general population context. METHODS: We performed an incident user cohort study with time-stratified propensity score matching using a UK general population database between 1 January 2000 and 31 December 2014. To account for potential confounders, we compared propensity score-matched cohorts of statin initiators and non-initiators using 1-year cohort accrual blocks...
July 11, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28696807/association-between-polycystic-ovary-syndrome-and-the-risk-of-stroke-and-all-cause-mortality-insights-from-a-meta-analysis
#12
Yaqiong Zhou, Xiaoyun Wang, Yongrong Jiang, Honglan Ma, Li Chen, Chenglin Lai, Chunrong Peng, Caiyun He, Chaofeng Sun
Many epidemiologic literatures have investigated the link between PCOS and long-term stroke risk and all-cause mortality, but the results are surprisingly conflicting. A meta-analysis was performed to examine the link between polycystic ovary syndrome (PCOS) and the risk of stroke, death from any cause, and assessed whether BMI might explain a higher risk of stroke. We searched the PUBMED, EMBASE, and Cochrane Library databases with no restrictions. Nine Cohort studies were identified, involving a total of 237,647 subjects...
July 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28693510/can-china-achieve-a-one-third-reduction-in-premature-mortality-from-non-communicable-diseases-by-2030
#13
Yichong Li, Xinying Zeng, Jiangmei Liu, Yunning Liu, Shiwei Liu, Peng Yin, Jinlei Qi, Zhenping Zhao, Shicheng Yu, Yuehua Hu, Guangxue He, Alan D Lopez, George F Gao, Linhong Wang, Maigeng Zhou
BACKGROUND: The United Nation's Sustainable Development Goals for 2030 include reducing premature mortality from non-communicable diseases (NCDs) by one third. To assess the feasibility of this goal in China, we projected premature mortality in 2030 of NCDs under different risk factor reduction scenarios. METHODS: We used China results from the Global Burden of Disease Study 2013 as empirical data for projections. Deaths between 1990 and 2013 for cardiovascular disease (CVD), diabetes, chronic respiratory disease, cancer, and other NCDs were extracted, along with population numbers...
July 11, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28691547/reduced-risk-of-reoperation-after-treatment-of-femoral-neck-fractures-with-total-hip-arthroplasty
#14
Susanne Hansson, Szilard Nemes, Johan Kärrholm, Cecilia Rogmark
Background and purpose - Femoral neck fractures (FNFs) are commonly treated with some kind of arthroplasty, but evidence on whether to use hemiarthroplasty (HA) or total hip arthroplasty (THA) is lacking. HA reduces the risk of dislocation, but may lead to acetabular erosion. THA implies longer surgery and increased bleeding. THA may result in better function and health-related quality of life, but evidence is contradictory. We compared HA and THA and in terms of revision, reoperation and death. Patients and methods - Data were extracted from the Swedish Hip Arthroplasty Register for 11,253 patients with acute FNF receiving cemented HA or THA during 2008-2012...
July 10, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28679015/association-between-weight-change-health-outcomes-and-mortality-in-older-residents-in-long-term-care
#15
Wei Zhou, Andrzej Kozikowski, Renee Pekmezaris, James Lolis, Barbara Tommasulo, Joanna Fishbein, Gisele Wolf-Klein
OBJECTIVES: Despite the numerous health risks associated with being overweight, the effect of weight loss on health and longevity remains controversial, particularly in older adults. We explored the association among weight changes, health outcomes, and mortality in older residents of a skilled nursing facility. METHODS: A 6-year retrospective chart review of residents of a long-term care facility was conducted, collecting monthly weights in addition to the clinical and demographic data of all residents for at least 1 year...
July 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28678695/body-mass-index-and-mortality-in-a-very-large-cohort-is-it-really-healthier-to-be-overweight
#16
Arthur L Klatsky, Jasmine Zhang, Natalia Udaltsova, Yan Li, H Nicole Tran
CONTEXT: Controversy persists about optimal body weight. Many experts define "normal" (healthy) body mass index (BMI) as 18.5 to 24.9 kg/m(2), 25 to 29.9 kg/m(2) as overweight, and 30 kg/m(2) or greater as obese. Obesity is subdivided into 30 to 34.9 kg/m(2) (Grade 1), 35 to 39.9 kg/m(2) (Grade 2), and 40 kg/m(2) and above (Grade 3). Studies consistently show higher mortality for underweight and Grade 2 or 3 obesity, but results conflict for the overweight category and Grade 1 obesity...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28671751/body-fat-distribution-is-more-predictive-of-all-cause-mortality-than-overall-adiposity
#17
Sung Woo Lee, Jee Young Son, Jeong Min Kim, Seung-Sik Hwang, Jin Suk Han, Nam Ju Heo
AIMS: The relationship between directly measured body fat and all-cause mortality has been rarely studied. The aim of this study was to evaluate the predictive significance of computed tomography (CT)-measured body fat, including both visceral fat area (VFA) and subcutaneous fat area (SFA), for mortality. METHODS: The study included 36,656 participants who underwent abdominal CT as part of a health check-up at a single university-affiliated healthcare centre in 2007-2015...
July 3, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28669161/overweight-is-it-a-prognostic-factor-in-women-with-triple-negative-breast-cancer
#18
Ouissam Al Jarroudi, Naima Abda, Youssef Seddik, Sami Aziz Brahmi, Said Afqir
Background: Obesity is associated with poor outcomes in patients with breast cancer expressing hormone receptors, but this association is not well established for triple-negative breast cancer. In this study, we investigated the influence of body mass index (BMI) in triple-negative breast cancer outcomes. Methods: This is a descriptive and analytical retrospective cohort study at the Regional Oncology Center Hassan II-Oujda. We identified 115 patients with triple-negative breast cancer, met the criteria for inclusion, treated between January 2009 and December 2011...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28667447/the-association-between-leisure-time-physical-activity-low-hdl-cholesterol-and-mortality-in-a-pooled-analysis-of-nine-population-based-cohorts
#19
Gary O'Donovan, David Stensel, Mark Hamer, Emmanuel Stamatakis
The objective of this study was to investigate associations between leisure-time physical activity, low high-density lipoprotein cholesterol (HDL-C) and mortality. Self-reported leisure-time physical activity, HDL-C concentration, and mortality were assessed in 37,059 adults in Health Survey for England and Scottish Health Survey. Meeting physical activity guidelines was defined as ≥150 min wk(-1) of moderate-intensity activity, ≥75 min wk(-1) of vigorous-intensity activity, or equivalent combinations...
June 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28666367/adolescent-body-mass-index-and-cardiovascular-disease-specific-mortality-by-midlife
#20
Gilad Twig, Dana Ben-Ami Shor, Ariel Furer, Hagai Levine, Estela Derazne, Nehama Goldberger, Ziona Haklai, Moran Levy, Arnon Afek, Adi Leiba, Jeremy D Kark
Context: As opposed to coronary heart disease (CHD) mortality, cardiovascular mortality attributed to non-CHD causes has increased. Objective: To evaluate the association of body mass index (BMI) in late adolescence with mortality attributed to non-CHD cardiovascular sequelae. Design & setting: A Nationwide cohort. Participants: 2,294,139 adolescents examined between 1967 and 2010. Interventions: Height and weight were measured at age 17...
June 9, 2017: Journal of Clinical Endocrinology and Metabolism
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