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https://www.readbyqxmd.com/read/28432383/increased-blood-cadmium-levels-were-not-associated-with-increased-fracture-risk-but-with-increased-total-mortality-in-women-the-malm%C3%A3-diet-and-cancer-study
#1
L Moberg, P M Nilsson, G Samsioe, G Sallsten, L Barregard, G Engström, C Borgfeldt
This study aimed to investigate if high levels of blood cadmium at baseline were associated with increased fracture risk during follow-up in middle-aged women. No increased fracture risk was observed during follow-up, but women with higher levels of cadmium had an increased overall mortality. INTRODUCTION: Exposure to high levels of cadmium has been associated with an increased fracture risk. The aim was to investigate a perceived association between low levels of blood cadmium (B-Cd) at baseline and risk of first incident fracture...
April 21, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28429111/impact-of-serum-albumin-levels-on-long-term-outcomes-in-patients-undergoing-percutaneous-coronary-intervention
#2
Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Jun Shitara, Hirohisa Endo, Shinichiro Doi, Ryo Naito, Hirokazu Konishi, Shuta Tsuboi, Manabu Ogita, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Satoru Suwa, Hiroyuki Daida
Epidemiological studies have demonstrated an association between low serum albumin levels and both coronary artery disease (CAD) and mortality. However, the long-term clinical impact of low serum albumin level in patients with CAD undergoing percutaneous coronary intervention (PCI) has not yet been fully investigated. We studied 2860 all-comer patients with CAD who underwent their first PCI and had data available for pre-procedural serum albumin between 2000 and 2011. Patients were assigned to tertiles based on pre-procedural albumin levels...
April 20, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28426913/body-mass-index-weight-loss-and-cause-specific-mortality-in-rheumatoid-arthritis
#3
Bryant R England, Joshua F Baker, Harlan Sayles, Kaleb Michaud, Liron Caplan, Lisa A Davis, Grant W Cannon, Brian C Sauer, E Blair Solow, Andreas M Reimold, Gail S Kerr, Ted R Mikuls
OBJECTIVES: To examine associations of body mass index (BMI) and weight loss with cause-specific mortality in rheumatoid arthritis (RA). METHODS: A cohort of U.S. Veterans with RA were followed until death or through 2013. BMI was categorized as underweight, normal, overweight, and obese. Weight loss was calculated as the: 1) annualized rate of change over the preceding 13 months and 2) cumulative percent. Vital status and cause of death were obtained from the National Death Index...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28417563/nutritional-parameters-as-mortality-predictors-in-haemodialysis-differences-between-genders
#4
Telma Sobral Oliveira, Ana Tentúgal Valente, Cristina Guerreiro Caetano, Cristina Antunes Garagarza
BACKGROUND: Malnutrition is common in patients undergoing haemodialysis (HD). Several studies have described different nutritional parameters as mortality predictors but few have studied whether there are differences between genders. This study aimed to evaluate which nutrition parameters may be associated with mortality in patients undergoing long-term HD depending on their gender. METHODS: Longitudinal prospective multicentre study with 12 months of follow-up...
April 17, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28416200/comparison-of-qrs-duration-and-associated-cardiovascular-events-in-american-indian-men-versus-women-the-strong-heart-study
#5
Jason F Deen, Dorothy A Rhoades, Carolyn Noonan, Lyle G Best, Peter M Okin, Richard B Devereux, Jason G Umans
Electrocardiographic QRS duration at rest is associated with sudden cardiac death and death from coronary heart disease in the general population. However, its relation to cardiovascular events in American Indians, a population with persistently high cardiovascular disease mortality, is unknown. The relation of QRS duration to incident cardiovascular disease during 17.2 years of follow-up was assessed in 1,851 male and female Strong Heart Study participants aged 45 to 74 years without known cardiovascular disease at baseline...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28416170/hepcidin-serum-levels-and-resistance-to-recombinant-human-erythropoietin-therapy-in-hemodialysis-patients
#6
Kristina Petrulienė, Edita Žiginskienė, Vytautas Kuzminskis, Irena Nedzelskienė, Inga Arūnė Bumblytė
OBJECTIVE: The aim of this study was to analyze the factors that are associated with the response to erythropoiesis-stimulating agents (ESAs) and its association with hospitalization and mortality rates; to evaluate the serum hepcidin level and its associations with iron profile, inflammatory markers, ESA responsiveness, and mortality; and to determine independent factors affecting ERI and hepcidin. MATERIALS AND METHODS: To evaluate a dose-response effect of ESAs we used the erythropoietin resistance index (ERI)...
March 31, 2017: Medicina
https://www.readbyqxmd.com/read/28414610/clinical-calculator-for-early-mortality-in-metastatic-colorectal-cancer-an-analysis-of-patients-from-28-clinical-trials-in-the-aide-et-recherche-en-canc%C3%A3-rologie-digestive-database
#7
Lindsay A Renfro, Richard M Goldberg, Axel Grothey, Alberto Sobrero, Richard Adams, Matthew T Seymour, Volker Heinemann, Hans-Joachim Schmoll, Jean-Yves Douillard, Herbert Hurwitz, Charles S Fuchs, Eduardo Diaz-Rubio, Rainer Porschen, Christophe Tournigand, Benoist Chibaudel, Paulo M Hoff, Fairooz F Kabbinavar, Alfredo Falcone, Niall C Tebbutt, Cornelis J A Punt, J Randolph Hecht, John Souglakos, Carsten Bokemeyer, Eric Van Cutsem, Leonard Saltz, Aimery de Gramont, Daniel J Sargent
Purpose Factors contributing to early mortality after initiation of treatment of metastatic colorectal cancer are poorly understood. Materials and Methods Data from 22,654 patients enrolled in 28 randomized phase III trials contained in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were pooled. Multivariable logistic regression models for 30-, 60-, and 90-day mortality were constructed, including clinically and statistically significant patient and disease factors and interaction terms. A calculator (nomogram) for 90-day mortality was developed and validated internally using bootstrapping methods and externally using a 10% random holdout sample from each trial...
April 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28406852/survivorship-after-high-energy-geriatric-trauma
#8
Ida Leah Gitajn, Renan Castillo, Stephen Breazeale, Carrie Schoonover, Peter Berger, Yanjie Huang, Nathan O'Hara, Robert V O'Toole, Marcus F Sciadini
OBJECTIVES: To evaluate in-hospital, 1-year, and 5-year survivorship of geriatric patients after high-energy trauma, to compare survivorship of geriatric patients who sustained high-energy trauma with that of those who sustained low-energy trauma, and to identify predictors for mortality. DESIGN: Retrospective. SETTING: Urban Level I trauma center. PATIENTS: Study group of 1849 patients with high-energy trauma and comparison group of 761 patients with low-energy trauma...
April 18, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28405877/revision-roux-en-y-gastric-bypass-to-biliopancreatic-long-limb-gastric-bypass-for-inadequate-weight-response-case-series-and-analysis
#9
Henry Buchwald, Danette M Oien
BACKGROUND: The long-limb Roux-en-Y gastric bypass (LLRYGB) was introduced in 1987 as a salvage operation for inadequate weight loss after a standard Roux-en-Y gastric bypass (RYGB). METHODS: We report on 53 consecutive patients (44 females) with conversion of a failed RYGB to a LLRYGB performed by a single surgeon between 2002 and 2014. No patient had an ascertainable anatomic abnormality to explain his/her weight regain. LLRYGB revision consisted of a 75-cm to 100-cm alimentary Roux limb and a 75-cm to 100-cm common channel; after 2011, in suitable patients, the Roux limb was lengthened to greater than 250 cm...
April 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28400368/relationship-between-peak-troponin-values-and-long-term-ischemic-events-among-medically-managed-patients-with-acute-coronary-syndromes
#10
Sarah A Goldstein, L Kristin Newby, Derek D Cyr, Megan Neely, Thomas F Lüscher, Eileen B Brown, Harvey D White, E Magnus Ohman, Matthew T Roe, Christian W Hamm
BACKGROUND: The relationship between troponin level and outcomes among patients with non-ST-segment elevation ACS is established, but the relationship of troponin level with long-term outcomes among medically managed non-ST-segment elevation ACS patients receiving contemporary antiplatelet therapy is inadequately defined. METHODS AND RESULTS: In 6763 medically managed non-ST-segment elevation ACS patients randomized in TRILOGY ACS (Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes) (prasugrel versus clopidogrel), we examined relationships between categories of peak troponin/upper limit of normal (ULN) ratio within 48 hours of the index ACS event (≈4...
April 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28399126/fresh-fruit-consumption-in-relation-to-incident-diabetes-and-diabetic-vascular-complications-a-7-y-prospective-study-of-0-5-million-chinese-adults
#11
Huaidong Du, Liming Li, Derrick Bennett, Yu Guo, Iain Turnbull, Ling Yang, Fiona Bragg, Zheng Bian, Yiping Chen, Junshi Chen, Iona Y Millwood, Sam Sansome, Liangcai Ma, Ying Huang, Ningmei Zhang, Xiangyang Zheng, Qiang Sun, Timothy J Key, Rory Collins, Richard Peto, Zhengming Chen
BACKGROUND: Despite the well-recognised health benefits of fresh fruit consumption, substantial uncertainties remain about its potential effects on incident diabetes and, among those with diabetes, on risks of death and major vascular complications. METHODS AND FINDINGS: Between June 2004 and July 2008, the nationwide China Kadoorie Biobank study recruited 0.5 million adults aged 30-79 (mean 51) y from ten diverse localities across China. During ~7 y of follow-up, 9,504 new diabetes cases were recorded among 482,591 participants without prevalent (previously diagnosed or screen-detected) diabetes at baseline, with an overall incidence rate of 2...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28395286/heart-failure-with-preserved-and-reduced-ejection-fraction-in-hemodialysis-patients-prevalence-disease-prediction-and-prognosis
#12
Marlies Antlanger, Stefan Aschauer, Chantal Kopecky, Manfred Hecking, Johannes J Kovarik, Johannes Werzowa, Julia Mascherbauer, Bernd Genser, Marcus D Säemann, Diana Bonderman
BACKGROUND/AIMS: Heart failure (HF) is a main cause of mortality of hemodialysis (HD) patients. While HF with reduced ejection fraction (HFrEF) is known to only affect a minority of patients, little is known about the prevalence, associations with clinical characteristics and prognosis of HF with preserved ejection fraction (HFpEF). METHODS: We included 105 maintenance HD patients from the Medical University of Vienna into this prospective single-center cohort study and determined the prevalence of HFpEF (per the 2013 criteria of the European Society of Cardiology) and HFrEF (EF <45%), using standardized post-HD transthoracic echocardiography...
April 11, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28393329/quality-of-life-of-liver-donors-following-donor-hepatectomy
#13
Biju Chandran, Viju Kumar Bharathan, Johns Shaji Mathew, Binoj Sivasankara Pillai Thankamony Amma, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran Narayana Menon, Puneet Dhar, Sudheer Othiyil Vayoth, Sudhindran Surendran
BACKGROUND: Although morbidity following living liver donation is well characterized, there is sparse data regarding health-related quality of life (HRQOL) of donors. METHODS: HRQOL of 200 consecutive live liver donors from 2011-2014 performed at an Indian center were prospectively collected using the SF-36 version 2, 1 year after surgery. The effect of donor demographics, operative details, post-operative complications (Clavien-Dindo and 50-50 criteria), and recipient mortality on the quality-of-life (QOL) scoring was analyzed...
April 10, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28392996/body-mass-index-is-inversely-associated-with-mortality-in-patients-with-acute-kidney-injury-undergoing-continuous-renal-replacement-therapy
#14
Hyoungnae Kim, Joohwan Kim, Changhwan Seo, Misol Lee, Min-Uk Cha, Su-Young Jung, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Chang-Yun Yoon, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Many epidemiologic studies have reported on the controversial concept of the obesity paradox. The presence of acute kidney injury (AKI) can accelerate energy-consuming processes, particularly in patients requiring continuous renal replacement therapy (CRRT). Thus, we aimed to investigate whether obesity can provide a survival benefit in this highly catabolic condition. METHODS: We conducted an observational study in 212 patients who had undergone CRRT owing to various causes of AKI between 2010 and 2014...
March 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28389195/two-long-term-mortality-risk-models-for-coronary-artery-bypass-graft-surgery-produced-in-american-populations-validated-in-an-australian-population
#15
Dr Matthew Kilpin, Dr Arpit Talwar, Dr James Meneguzzi, Dr Lavinia Tran, Professor Christopher Reid, Associate Professor Philip Hayward
BACKGROUND: Short-term mortality prediction models have an important role in current cardiac surgical practice. There has been much less attention paid to prediction of long-term outcomes which are probably an equal marker both of surgeon performance and appropriateness of surgical treatment. The aim of this study was to assess the performance of the New York State Cardiac Surgery Reporting System (NYSCSRS) risk model and the Northern New England Cardiovascular Disease Study Group (NNECDSG) risk model on the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) patient database...
March 15, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28388993/prognostic-impact-of-the-geriatric-nutritional-risk-index-on-long-term-outcomes-in-patients-who-underwent-percutaneous-coronary-intervention
#16
Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Shinichiro Doi, Ryo Naito, Hirokazu Konishi, Shuta Tsuboi, Manabu Ogita, Takatoshi Kasai, Ahmed Hassan, Shinya Okazaki, Kikuo Isoda, Satoru Suwa, Hiroyuki Daida
Malnutrition has been identified as an important predictor of poor clinical outcomes in patients with heart failure. The aim of this study is to examine the prognostic impact of nutritional status in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI). The impact of nutrition, assessed using the geriatric nutritional risk index (GNRI) calculated by serum albumin and body mass index, was evaluated in 2,853 patients with CAD who underwent their first PCI between 2000 and 2011...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28388895/development-and-validation-of-a-prognostic-score-during-tuberculosis-treatment
#17
Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Virginie Poka-Mayap, Hadja Koté Fatime-Abaicho, Patrick Thierry Enono-Edende, André Pascal Kengne
BACKGROUND: Death under care is a major challenge for tuberculosis (TB) treatment programs. We derived and validated a simple score to predict mortality during tuberculosis treatment in high endemicity areas. METHODS: We used data for patients aged ≥15 years, diagnosed and treated for tuberculosis at the Yaounde Jamot Hospital between January 2012 and December 2013. Baseline characteristics associated with mortality were investigated using logistic regressions...
April 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28385519/complications-and-readmission-after-lumbar-spine-surgery-in-elderly-patients-an-analysis-of-2-320-patients
#18
Ahmed Saleh, Caroline Thirukumaran, Addisu Mesfin, Robert W Molinari
BACKGROUND CONTEXT: There is a paucity of literature describing risk factors for adverse outcomes after geriatric lumbar spinal surgery. As the geriatric population increases, so does the number of lumbar spinal surgeries in this cohort. PURPOSE: The purpose of the study is to determine how safe is lumbar surgery in elderly patients? Does patient selection, type of surgery, length of surgery, and other elderly patient comorbidities affect complication and readmission rates after surgery? STUDY DESIGN/SETTING: Retrospective Cohort Study PATIENT SAMPLE: American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) Database...
April 3, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28384755/weight-history-and-all-cause-and-cause-specific-mortality-in-three-prospective-cohort-studies
#19
Edward Yu, Sylvia H Ley, JoAnn E Manson, Walter Willett, Ambika Satija, Frank B Hu, Andrew Stokes
Background: The relationship between body mass index (BMI) and mortality is controversial. Objective: To investigate the relationship between maximum BMI over 16 years and subsequent mortality. Design: 3 prospective cohort studies. Setting: Nurses' Health Study I and II and Health Professionals Follow-Up Study. Participants: 225 072 men and women with 32 571 deaths observed over a mean of 12...
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28381339/association-of-mortality-and-phase-angle-measured-by-different-bioelectrical-impedance-analysis-bia-devices
#20
Laurence Genton, François R Herrmann, Adrian Spörri, Christophe E Graf
PURPOSE: A high phase angle measured by the Nutriguard(®) bioelectrical impedance analysis device is associated with a reduced mortality risk in older people. This retrospective study aims to analyze whether this association persists with the other devices that have been used in our hospital. METHODS: This study encompasses all people 65 yrs and older who underwent a phase angle measurement between 1990 and 2011 at the Geneva University Hospitals, with the RJL-101(®) (RJL Systems), Xitron 4000B(®) (Xitron Technologies), Eugedia(®) (Eugédia-Spengler) and Bio-Z(®) (Spengler)...
March 23, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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