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https://www.readbyqxmd.com/read/28801121/impact-of-hyperuricemia-on-long-term-outcomes-of-kidney-transplantation-analysis-of-the-favorit-study
#1
Roberto S Kalil, Myra A Carpenter, Anastasia Ivanova, Lisa Gravens-Mueller, Alin A John, Matthew R Weir, Todd Pesavento, Andrew G Bostom, Marc A Pfeffer, Lawrence G Hunsicker
BACKGROUND: Elevated uric acid concentration is associated with higher rates of cardiovascular (CV) morbidity and mortality in the general population. It is not known whether hyperuricemia increases the risk for CV death or transplant failure in kidney transplant recipients. STUDY DESIGN: Post hoc cohort analysis of the FAVORIT Study, a randomized controlled trial that examined the effect of homocysteine-lowering vitamins on CV disease in kidney transplantation...
August 9, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28796857/association-of-systemic-inflammation-and-sarcopenia-with-survival-in-nonmetastatic-colorectal-cancer-results-from-the-c-scans-study
#2
Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Jeffrey A Meyerhardt, Carla M Prado, Patrick T Bradshaw, Marilyn L Kwan, Jingjie Xiao, Stacey Alexeeff, Douglas Corley, Erin Weltzien, Adrienne L Castillo, Bette J Caan
Importance: Systemic inflammation and sarcopenia are easily evaluated, predict mortality in many cancers, and are potentially modifiable. The combination of inflammation and sarcopenia may be able to identify patients with early-stage colorectal cancer (CRC) with poor prognosis. Objective: To examine associations of prediagnostic systemic inflammation with at-diagnosis sarcopenia, and determine whether these factors interact to predict CRC survival, adjusting for age, ethnicity, sex, body mass index, stage, and cancer site...
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28795149/access-to-heart-transplantation-a-proper-analysis-of-the-competing-risks-of-death-and-transplantation-is-required-to-optimize-graft-allocation
#3
Christelle Cantrelle, Camille Legeai, Aurélien Latouche, Philippe Tuppin, Carine Jasseron, Laurent Sebbag, Olivier Bastien, Richard Dorent
BACKGROUND: Heart allocation systems are usually urgency-based, offering grafts to candidates at high risk of waitlist mortality. In the context of a revision of the heart allocation rules, we determined observed predictors of 1-year waitlist mortality in France, considering the competing risk of transplantation, to determine which candidate subgroups are favored or disadvantaged by the current allocation system. METHODS: Patients registered on the French heart waitlist between 2010 and 2013 were included...
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28793990/independent-and-joint-associations-of-grip-strength-and-adiposity-with-all-cause-and-cardiovascular-disease-mortality-in-403-199-adults-the-uk-biobank-study
#4
Youngwon Kim, Katrien Wijndaele, Duck-Chul Lee, Stephen J Sharp, Nick Wareham, Soren Brage
Background: Higher grip strength (GS) is associated with lower mortality risk. However, whether this association is independent of adiposity is uncertain.Objective: The purpose of this study was to examine the associations between GS, adiposity, and mortality.Design: The UK Biobank study is an ongoing prospective cohort of >0.5 million UK adults aged 40-69 y. Baseline data collection (2006-2010) included measurements of GS and adiposity indicators, including body mass index (BMI; in kg/m(2)). Age- and sex-specific GS quintiles were used...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28790815/development-of-the-propal-copd-tool-to-identify-patients-with-copd-for-proactive-palliative-care
#5
R G Duenk, C Verhagen, E M Bronkhorst, R S Djamin, G J Bosman, E Lammers, Pnr Dekhuijzen, Kcp Vissers, Y Engels, Y Heijdra
BACKGROUND: Our objective was to develop a tool to identify patients with COPD for proactive palliative care. Since palliative care needs increase during the disease course of COPD, the prediction of mortality within 1 year, measured during hospitalizations for acute exacerbation COPD (AECOPD), was used as a proxy for the need of proactive palliative care. PATIENTS AND METHODS: Patients were recruited from three general hospitals in the Netherlands in 2014. Data of 11 potential predictors, a priori selected based on literature, were collected during hospitalization for AECOPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28776529/treatment-outcome-of-patients-having-extensively-drug-resistant-tuberculosis-in-gujarat-india
#6
Krunal Prajapati, Vishal Mishra, Mira Desai, Rajesh Solanki, Purvi Naik
BACKGROUND: To investigate the factors affecting treatment outcome of extensively drug resistant tuberculosis (XDR-TB) in Gujarat, India. METHODS: A prospective, observational study was conducted on patients with XDR TB from January 2012 to October 2016. Details of demography, clinical symptoms, sputum/culture and radiological examination, drug treatment, adverse drug reactions (ADRs) and treatment outcome were recorded in pretested case record form (CRF). Data was analyzed using Fisher's exact test and paired student's t test...
July 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28776245/burden-of-cardiovascular-diseases-in-the-eastern-mediterranean-region-1990-2015-findings-from-the-global-burden-of-disease-2015-study
#7
Ali H Mokdad
OBJECTIVES: To report the burden of cardiovascular diseases (CVD) in the Eastern Mediterranean Region (EMR) during 1990-2015. METHODS: We used the 2015 Global Burden of Disease study for estimates of mortality and disability-adjusted life years (DALYs) of different CVD in 22 countries of EMR. RESULTS: A total of 1.4 million CVD deaths (95% UI: 1.3-1.5) occurred in 2015 in the EMR, with the highest number of deaths in Pakistan (465,116) and the lowest number of deaths in Qatar (723)...
August 3, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28776154/sleeve-gastrectomy-after-liver-transplantation-feasibility-and-outcomes
#8
Michael Osseis, Andrea Lazzati, Chady Salloum, Concepcion Gomez Gavara, Philippe Compagnon, Cyrille Feray, Chetana Lim, Daniel Azoulay
BACKGROUND: Knowledge regarding the feasibility and safety of sleeve gastrectomy (SG) in obese liver transplant recipients is scarce. We report our experience of sleeve gastrectomy following liver transplantation (LT). METHODS: All patients who had undergone LT and subsequently underwent SG at our institution were retrospectively reviewed. Surgical outcomes, liver and kidney function tests, outcomes of obesity-related comorbidities, and excess weight loss were analyzed...
August 3, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28774873/a-growth-reference-for-mid-upper-arm-circumference-for-age-among-school-age-children-and-adolescents-and-validation-for-mortality-growth-curve-construction-and-longitudinal-cohort-study
#9
Lazarus Mramba, Moses Ngari, Martha Mwangome, Lilian Muchai, Evasius Bauni, A Sarah Walker, Diana M Gibb, Gregory Fegan, James A Berkley
Objectives To construct growth curves for mid-upper-arm circumference (MUAC)-for-age z score for 5-19 year olds that accord with the World Health Organization growth standards, and to evaluate their discriminatory performance for subsequent mortality.Design Growth curve construction and longitudinal cohort study.Setting United States and international growth data, and cohorts in Kenya, Uganda, and Zimbabwe.Participants The Health Examination Survey (HES)/National Health and Nutrition Examination Survey (NHANES) US population datasets (age 5-25 years), which were used to construct the 2007 WHO growth reference for body mass index in this age group, were merged with an imputed dataset matching the distribution of the WHO 2006 growth standards age 2-6 years...
August 3, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28767447/prevalence-and-survival-prognosis-of-prostate-cancer-in-patients-with-end-stage-renal-disease-a-retrospective-study-based-on-the-korea-national-database-2003-2010
#10
Sung Han Kim, Jae Young Joung, Yoon Seok Suh, Young Ae Kim, Jin Hyuk Hong, Tong Sun Kuark, Eun Sook Lee, Kang Hyun Lee
OBJECTIVE: The study was aimed to evaluate the prevalence and prognosis of prostate cancer (PC) and end-stage renal disease (ESRD), determine the risk factors for overall survival (OS) and PC-specific survival (CSS), and evaluate differences in PC-related clinical therapeutic patterns between patients with and without PC-ESRD. METHODS: This observational population study, performed at the National Cancer Center and Cancer Research Institute in Korea, included patients with PC and ESRD from the nationwide Korean Health Insurance System and Korean Central Cancer Registry data...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765555/body-mass-index-waist-to-hip-ratio-and-late-outcomes-a-report-from-the-shanghai-breast-cancer-survival-study
#11
Minlu Zhang, Hui Cai, Pingping Bao, Wanghong Xu, Guoyou Qin, Xiao Ou Shu, Ying Zheng
Obesity has been well studied in relation to breast cancer survival. However, the associations of post-diagnosis obesity and late outcomes (≥5 years after diagnosis) have been much less studied. A total of 4062 5-year disease-free patients were recruited from the Shanghai Breast Cancer Survival Study, a longitudinal study of patients diagnosed during 2002-2006. Cox proportional hazard model with restricted cubic spline were used to evaluate the potential non-linear associations of post-diagnosis body mass index (BMI) and waist-to-hip ratio (WHR) with late all-cause mortality and late recurrence...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28761655/changes-in-risk-factors-and-their-contribution-to-reduction-of-mortality-risk-following-gastric-bypass-surgery-among-obese-individuals-with-type-2-diabetes-a-nationwide-matched-observational-cohort-study
#12
Vasileios Liakopoulos, Stefan Franzén, Ann-Marie Svensson, Björn Zethelius, Johan Ottosson, Ingmar Näslund, Soffia Gudbjörnsdottir, Björn Eliasson
OBJECTIVE: We recently showed that Roux-en-Y gastric bypass (RYGB) reduces risks of mortality, cardiovascular death and myocardial infarction in obese individuals compared with matched patients with diabetes mellitus (DM). We have examined changes in risk factors after RYGB, with the aim of explaining these effects. RESEARCH DESIGN AND METHODS: We matched (1:1) 6132 RYGB patients with DM reported to the Scandinavian Obesity Surgery Register with patients who had not undergone RYGB, based on sex, age, body mass index (BMI) and time, and assessed effects 2007-2014...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28760742/all-cause-and-specific-cause-mortality-risk-after-roux-en-y-gastric-bypass-in-patients-with-and-without-diabetes
#13
Michelle R Lent, Peter N Benotti, Tooraj Mirshahi, Glenn S Gerhard, William E Strodel, Anthony T Petrick, Jon D Gabrielsen, David D Rolston, Christopher D Still, Annemarie G Hirsch, Fahad Zubair, Adam Cook, David J Carey, G Craig Wood
OBJECTIVE: This study assessed all-cause and specific-cause mortality after Roux-en-Y gastric bypass (RYGB) and in matched control subjects, stratified by diabetes status. RESEARCH DESIGN AND METHODS: RYGB patients were matched by age, BMI, sex, and diabetes status at time of surgery to nonsurgical control subjects using data from the electronic health record. Kaplan-Meier curves and Cox regression were used to assess differences in all-cause and specific-cause mortality between RYGB patients and control subjects with and without diabetes...
July 31, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28760430/is-maternal-body-mass-index-associated-with-neonatal-mortality-a-pooled-analysis-of-nationally-representative-data-from-nine-asian-countries
#14
Rajesh Kumar Rai, Lucky Singh, Prashant Kumar Singh
OBJECTIVE: Children born to mothers with abnormal body mass index (BMI) have increased risk for mortality. The aim of this study was to investigate whether maternal BMI is a risk factor for neonatal death in select Asian countries, including the nature of association between maternal BMI and the discrete timing of neonatal death. METHODS: Nationally representative, the standard Demographic and Health Survey data from nine Asian countries were used. In all, 55 629 mothers reported their index birth; 840 reported neonatal mortality...
September 2017: Nutrition
https://www.readbyqxmd.com/read/28759582/the-association-between-a-body-shape-index-and-mortality-results-from-an-australian-cohort
#15
Janet F Grant, Catherine R Chittleborough, Zumin Shi, Anne W Taylor
It is well recognised that obesity increases the risk of premature death. A Body Shape Index (ABSI) is a formula that uses waist circumference (WC), body mass index (BMI) and height to predict risk of premature mortality, where a high score (Quartile 4) indicates that a person's WC is more than expected given their height and weight. Our study examines the association between ABSI quartiles and all-cause-, cardiovascular- and cancer-related mortality, and primary cause of death. Self-reported demographic and biomedically measured health-related risk factor and weight data was from the baseline stage of the North West Adelaide Health Study (1999-2003, n = 4056), a longitudinal cohort of Australian adults...
2017: PloS One
https://www.readbyqxmd.com/read/28758155/apol1-renal-risk-variants-do-not-associate-with-incident-cardiovascular-disease-or-mortality-in-the-systolic-blood-pressure-intervention-trial
#16
Barry I Freedman, Michael V Rocco, Jeffrey T Bates, Michel Chonchol, Amret T Hawfield, James P Lash, Vasilios Papademetriou, John R Sedor, Karen Servilla, Paul L Kimmel, Barry M Wall, Nicholas M Pajewski
INTRODUCTION: Relationships between apolipoprotein L1 gene (APOL1) renal-risk variants (RRVs) and cardiovascular disease (CVD) remain controversial. To clarify associations between APOL1 and CVD, 2,568 African American Systolic Blood Pressure Intervention Trial (SPRINT) participants were assessed for the incidence of CVD events (primary composite including non-fatal myocardial infarction, acute coronary syndrome not resulting in myocardial infarction, nonfatal stroke, non-fatal acute decompensated heart failure, and CVD death), renal outcomes, and all-cause mortality...
July 2017: KI Reports
https://www.readbyqxmd.com/read/28754502/the-impact-of-musculoskeletal-diseases-on-mortality-comparison-with-internal-diseases-a-15-year-longitudinal-study
#17
Takehiro Kasai, Yukiharu Hasegawa, Shiro Imagama, Tadahiro Sakai, Kenji Wakai, Koji Suzuki, Naoki Ishiguro
BACKGROUND: Aging is associated with an increased incidence of diabetes (DM), hypertension (HT), hyperlipidemia (HL), as well as musculoskeletal disorders, such as osteoarthritis (OA) and osteoporosis (OP). However, the impact of musculoskeletal disorders on mortality remains unclear. This study investigated the risk of mortality if having knee OA or OP. METHODS: 601 participants (mean age 67.8 ± 5.3 years) who underwent musculoskeletal check-ups in Yakumo town were enrolled in this study, 248 were males and 353 were females...
July 25, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28748376/assessment-of-gestational-diabetes-and-associated-risk-factors-and-outcomes-in-the-pacific-island-nation-of-palau
#18
Mindy S Sugiyama, Haley L Cash, Christine Roseveare, Rumi Reklai, Kliu Basilius, Sherilynn Madraisau
Objective Gestational diabetes mellitus (GDM) in Palau and across the Pacific Islands is a serious public health issue that is currently understudied. Methods This study was a retrospective cohort study that included 1730 women with a single live birth in Palau between January 2007 and December 2014. Results The overall prevalence of GDM among women in Palau was 5.5%. Women who were older (≥30 years) or obese (BMI ≥30) were more likely to have GDM than women who were younger (<30 years) or non-obese (BMI <30), respectively...
July 26, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28747576/a-prospective-appraisal-of-preoperative-body-mass-index-in-d2-resected-patients-with-non-metastatic-gastric-carcinoma-and-siewert-type-ii-iii-adenocarcinoma-of-esophagogastric-junction-results-from-a-large-scale-cohort
#19
Lei Huang, Zhi-Jian Wei, Tuan-Jie Li, Yu-Ming Jiang, A-Man Xu
OBJECTIVE: To prospectively investigate associations of presurgical body mass index (BMI) with clinicopathological factors and its prognostic significance in radically D2-resected patients with non-metastasized gastric cancer (GC) and Siewert type II/III adenocarcinoma of esophagogastric junction (AEG). METHODS: A large prospective cohort consisting of radically-resected GC and AEG patients was analyzed. Follow-up was successful in 671 out of 700 patients, who were categorized into underweight (BMI<18...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28744600/excess-of-all-cause-mortality-after-a-fracture-in-type-2-diabetic-patients-a-population-based-cohort-study
#20
D Martinez-Laguna, X Nogues, B Abrahamsen, C Reyes, C Carbonell-Abella, A Diez-Perez, D Prieto-Alhambra
Post-fracture mortality in type 2 diabetes mellitus (T2DM) patients has been poorly studied. We report an absolute and relative excess all-cause mortality following a fracture in these patients compared to non-diabetic patients. INTRODUCTION: T2DM and osteoporotic fractures are independently associated with a reduced lifespan, but it is unknown if T2DM confers an excess post-fracture mortality compared to non-diabetic fracture patients. We report post-fracture all-cause mortality according to T2DM status...
July 25, 2017: Osteoporosis International
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