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https://www.readbyqxmd.com/read/29778492/tanovea%C3%A2-for-the-treatment-of-lymphoma-in-dogs
#1
REVIEW
Erik De Clercq
Tanovea® (first named GS-9219, then VDC-1101, generic name: rabacfosadine) is a pro-prodrug or "double" prodrug of PMEG [9-(2-phosphonylmethoxyethyl)guanine], which has been conditionally approved by the US FDA (Food and Drug Administration) for the treatment of lymphoma in dogs. Tanovea has been demonstrated to be effective against non-Hodgkin's lymphoma (NHL) in dogs, as well as canine cutaneous T-cell lymphoma, spontaneous canine multiple myeloma, naïve canine multicentric lymphoma and relapsed canine B-cell lymphoma...
May 17, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29773072/formal-procedure-to-facilitate-the-decision-to-withhold-or-withdraw-life-sustaining-interventions-in-a-neonatal-intensive-care-unit-a-seven-year-retrospective-study
#2
G Sorin, R Vialet, B Tosello
BACKGROUND: Neonatal deaths are often associated with the complex decision to limit or withdraw life-sustaining interventions (LSIs) rather than therapeutic impasses. Despite the existence of a law, significant disparities in clinical procedures remain. This study aimed to assess deaths occurring in a Neonatal Intensive Care Unit (NICU) and measure the impact of a traceable Limitation or Withdrawal of Active Treatment (LWAT) file on the treatment of these newborns. METHODS: In this monocentric retrospective study, we reviewed all consecutive neonatal deaths occurring during two three-year periods among patients in the NICU at the North Hospital of Marseille: cohort 1 (from 2009 to 2011 without the LWAT file) and cohort 2 (from 2013 to 2015 after introduction of the LWAT file)...
May 17, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29769232/end-tidal-carbon-dioxide-output-in-manual-cardiopulmonary-resuscitation-versus-active-compression-decompression-device-during-prehospital-quality-controlled-resuscitation-a-case-series-study
#3
Piritta Anniina Setälä, Ilkka Tapani Virkkunen, Antti Jaakko Kämäräinen, Heini Sisko Annamari Huhtala, Janne Severi Virta, Arvi Mikael Yli-Hankala, Sanna Elisa Hoppu
BACKGROUND: Active compression-decompression (ACD) devices have enhanced end-tidal carbon dioxide (ETCO2 ) output in experimental cardiopulmonary resuscitation (CPR) studies. However, the results in out-of-hospital cardiac arrest (OHCA) patients have shown inconsistent outcomes, and earlier studies lacked quality control of CPR attempts. We compared manual CPR with ACD-CPR by measuring ETCO2 output using an audiovisual feedback defibrillator to ensure continuous high quality resuscitation attempts...
May 16, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29768077/strategy-to-address-private-location-cardiac-arrest-a-public-safety-survey
#4
Jennifer Blackwood, Mickey Eisenberg, Dawn Jorgenson, James Nania, Bryan Howard, Bryan Collins, Peter Connell, Tim Day, Cody Rohrbach, Thomas Rea
OBJECTIVE: Most cardiac arrests occur in the private setting where response is often delayed and outcomes are poor. We surveyed public safety personnel to determine if they would volunteer to respond into private locations and/or be equipped with a personal automated external defibrillator (AED) as part of a vetted responder program that would use smart geospatial technology. METHODS: We conducted an anonymized survey among personnel from fire-based emergency medical services (EMS) and search and rescue organizations from Washington State...
May 16, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29764556/-extra-longtime-continuous-chest-compression-to-rescue-cardiopulmonary-arrest-a-case-report-and-the-literature-review
#5
Yan Zhang, Tianxue Yue, Kexin Sun, Jiang Wang, Ruiwu Zhu
The new cardiopulmonary resuscitation (CPR) guideline emphasize the importance of chest compression, which was considered as the first step to CPR. The duration for CPR is usually limited to 30 minutes. With the development of new technology and evidence-based medicine, the success of extra longtime CPR has become possible, which is of great significance to some patients with cardiac arrest (CA), but the time limit has not been determined. On February 23rd in 2016, a 76-year-old female patient with respiratory and cardiac arrest who was on the third day after transurethral resection of bladder tumor (TUR-BT) was admitted to the intensive care unit of the General Hospital of Fushun Mining Bureau...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764553/-interposed-abdominal-pulling-pressing-cardiopulmonary-resuscitation-improve-the-resuscitation-effect-for-patients-with-cardiac-arrest
#6
Dabing Wang, Xiaonan Feng, Yujuan Han
OBJECTIVE: To study the impact of interposed abdominal pulling-pressing cardiopulmonary resuscitation (IAPP-CPR) for patients with cardiac arrest (CA). METHODS: A prospective study was conducted. A total of 122 CA patients admitted to Department of Emergency of Shandong Provincial Mining Industry Group Company Central Hospital from July 2013 to December 2017 were enrolled. They were divided into standard cardiopulmonary resuscitation (S-CPR) group (n = 62) and IAPP-CPR group (n = 60) according to order of admission...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764541/-tianjin-characteristics-of-integrated-traditional-chinese-and-western-medicine-in-first-aid-medical-system
#7
Zhijun Li
Tianjin, as the earliest city to open up, the exchange of Chinese and Western cultures also started earlier. Therefore, today's emergency medicine system with integrated features of Chinese and Western medicine is formed. Professor Wang Jinda, who works in Tianjin First Center Hospital, makes the theory of "treating bronchitis and treating diseases" and "three methods of three syndromes" for the treatment of severe diseases such as sepsis. The surgical aspect is the treatment of acute abdomen with the combination of Chinese and Western medicine which is proposed by Academician Wu Xianzhong who worked in Tianjin Nankai Hospital...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764540/-2018-national-consensus-on-cardiopulmonary-resuscitation-training-in-china
#8
Lixiang Wang, Qingyi Meng, Tao Yu
To promote the technical training and scientific popularization of cardiopulmonary resuscitation (CPR) in China, the Cardiopulmonary Resuscitation Specialized Committee of Chinese Research Hospital Association combined with the Science Popularization Branch of the Chinese Medical Association wrote "2018 National consensus on cardiopulmonary resuscitation training in China". The formation was based on the general outline about "2016 National consensus on cardiopulmonary resuscitation in China", and to implement the important strategies included the "three pre" policy, prevention, precognition, and pre-warning, before the cardiac arrest (CA); the "three modernization" methods, standardized, diversified and individualized, during the CA; and the "three life" strategies, the rebirth, the extra and the extended, after the CA; and also combined with the concrete National conditions and clinical practice of China area...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29763712/cerebral-tissue-oximetry-levels-during-prehospital-management-of-cardiac-arrest-a-prospective-observational-study
#9
Gregor Prosen, Strnad Matej, Stephanie J Doniger, Andrej Markota, Andraž Stožer, Vesna Borovnik-Lesjak, Dušan Mekiš
INTRODUCTION: Near-infrared spectroscopy (NIRS) enables continuous monitoring of regional oximetry (rSO2 ). The aim of this study was to describe dynamics of regional cerebral oximetry levels during out of hospital cardiac arrest (OHCA) resuscitation, specifically around the time of restoration of spontaneous circulation (ROSC). METHODS: This prospective observational study was performed in the prehospital setting during cardio-pulmonary resuscitation (CPR) of OHCA patients...
May 12, 2018: Resuscitation
https://www.readbyqxmd.com/read/29755795/double-bolus-alteplase-therapy-during-cardiopulmonary-resuscitation-for-cardiac-arrest-due-to-massive-pulmonary-embolism-guided-by-focused-bedside-echocardiography
#10
Hafiz B Mahboob, Bruce W Denney
Massive pulmonary embolism (PE) frequently leads to cardiac arrest (CA) which carries an extremely high mortality rate. Although available, randomized trials have not shown survival benefits from thrombolytic use. Thrombolytics however have been used successfully during resuscitation in clinical practice in multiple case reports and in retrospective studies. Recent resuscitation guidelines recommend using alteplase for PE related CA; however they do not offer a standardized treatment regimen. The most consistently applied approach is an intravenous bolus of 50 mg tissue plasminogen activator (t-PA) early during cardiopulmonary resuscitation (CPR)...
2018: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29753857/the-effect-of-different-retraining-intervals-on-the-skill-performance-of-cardiopulmonary-resuscitation-in-laypeople-a-three-armed-randomized-control-study
#11
Ming-Ju Hsieh, Wen-Chu Chiang, Chyi-Feng Jan, Hao-Yang Lin, Chih-Wei Yang, Matthew Huei-Ming Ma
AIM: Our study aimed to compare cardiopulmonary resuscitation (CPR) performance among laypeople with different retraining intervals. METHODS: Ninety-six non-medical university students were randomly allocated into 3 groups after receiving initial CPR and automated external defibrillator (AED) training. Sixty participants completed the study. The participants in the 3-, 6-, and 12-month groups received the same retraining every 3-, 6-, and 12 months. An 80-minute retraining course comprised a video lecture and hands-on practice, with feedback from the instructors and the Resusci Anne® QCPR...
May 10, 2018: Resuscitation
https://www.readbyqxmd.com/read/29753856/analysis-of-bystander-cpr-quality-during-out-of-hospital-cardiac-arrest-using-data-derived-from-automated-external-defibrillators
#12
Shannon M Fernando, Christian Vaillancourt, Stanley Morrow, Ian G Stiell
BACKGROUND: Little is known regarding the quality of cardiopulmonary resuscitation (CPR) performed by bystanders in out-of-hospital cardiac arrest (OHCA). We sought to determine quality of bystander CPR provided during OHCA using CPR quality data stored by Automated External Defibrillators (AEDs). METHODS: We used the Resuscitation Outcomes Consortium database to identify OHCA cases of presumed cardiac etiology where an AED was utilized. We then matched AED data to each case identified...
May 10, 2018: Resuscitation
https://www.readbyqxmd.com/read/29751827/timp-2-igfbp7-predicts-acute-kidney-injury-in-out-of-hospital-cardiac-arrest-survivors
#13
Christoph Adler, Tobias Heller, Felix Schregel, Henning Hagmann, Martin Hellmich, Joana Adler, Hannes Reuter
BACKGROUND: Acute kidney injury (AKI) is a common complication after cardiopulmonary resuscitation (CPR) and predicts in-hospital mortality. To which extent post-resuscitation disease or the initial event of cardiac arrest and the duration of insufficient cardiac output triggers AKI is challenging to discriminate. Knowledge on molecular mediators of AKI is scarce. Early identification of patients at high risk of AKI is hampered by the low sensitivity of the established tests in clinical routine practice...
May 12, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29750875/ulinastatin-alleviates-neurological-deficiencies-evoked-by-transient-cerebral-ischemia-via-improving-autophagy-nrf-2-are-and-apoptosis-signals-in-hippocampus
#14
Xiao-Ming Jiang, Jing-Hai Hu, Lu-Lu Wang, Chi Ma, Xu Wang, Xiao-Liang Liu
Ulinastatin [or called as urinary trypsin inhibitor (UTI)] plays a role in regulating neurological deficits evoked by transient cerebral ischemia. However, the underlying mechanisms still need to be determined. The present study was to examine the effects of UTI on autophagy, Nrf2-ARE and apoptosis signal pathway in the hippocampus in the process of neurological functions after cerebral ischemia using a rat model of cardiac arrest (CA). CA was induced by asphyxia followed by cardiopulmonary resuscitation (CPR) in rats...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29750427/evaluation-of-knowledge-of-students-in-paediatric-dentistry-concerning-cardiopulmonary-resuscitation-skills-in-children
#15
L M De Mauro, L B Oliveira, C De Cássia Bergamaschi, J C Ramacciato, R H L Motta
AIM: The study evaluated the theoretical knowledge and practical ability of students in paediatric dentistry concerning basic life support (BLS) and cardiopulmonary resuscitation (CPR) in children and babies. METHODS: Seventy paediatric dentistry students answered a questionnaire and also performed a simulation of the manoeuvres of BLS and CPR on baby and child manikins. RESULTS: The results showed that 41 (58%) students had never received BLS training...
May 10, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29749525/quercetin-protects-against-inflammation-mmp%C3%A2-2-activation-and-apoptosis-induction-in-rat-model-of-cardiopulmonary-resuscitation-through-modulating-bmi%C3%A2-1-expression
#16
Dawei Wang, Xiaoqian Lou, Xiao-Ming Jiang, Chenxi Yang, Xiao-Liang Liu, Nan Zhang
With extensive pharmacological actions, quercetin has anti‑oxidant, free radical scavenging, anti‑tumor, anti‑inflammatory, anti‑bacterial and anti‑viral activity. Quercetin also reduces blood glucose and reduces high blood pressure, and has immunoregulation and cardiovascular protection functions. Additionally, it has been reported that it can reduce depression. The current study evaluated whether quercetin protects against inflammation, matrix metalloproteinase‑2 (MMP‑2) activation and apoptosis induction in a rat model of cardiopulmonary resuscitation (CPR), and whether Bmi‑1 expression was involved in the effects...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29746986/efficacy-and-safety-of-mechanical-versus-manual-compression-in-cardiac-arrest-a-bayesian-network-meta-analysis
#17
REVIEW
Safi U Khan, Ahmad N Lone, Swapna Talluri, Muhammad Z Khan, Muhammad U Khan, Edo Kaluski
AIM: To compare relative efficacy and safety of mechanical compression devices (AutoPulse and LUCAS) with manual compression in patients with cardiac arrest undergoing cardiopulmonary resuscitation (CPR). METHODS: For this Bayesian network meta-analysis, seven randomized controlled trials (RCTs) were selected using PubMed/Medline, EMBASE, and CENTRAL (Inception- 31 October 2017). For all the outcomes, median estimate of odds ratio (OR) from the posterior distribution with corresponding 95% credible interval (Cr I) was calculated...
May 7, 2018: Resuscitation
https://www.readbyqxmd.com/read/29746984/recognition-of-out-of-hospital-cardiac-arrest-during-emergency-calls-and-public-awareness-of-cardiopulmonary-resuscitation-in-communities-a-multilevel-analysis
#18
Sun Young Lee, Young Sun Ro, Sang Do Shin, Kyoung Jun Song, Ki Jeong Hong, Jeong Ho Park, So Yeon Kong
BACKGROUND: For an effective dispatcher-assisted cardiopulmonary resuscitation (CPR) program, recognition of out-of-hospital cardiac arrest (OHCA) by a dispatcher is the first step in initiating bystander CPR. This study evaluated whether CPR awareness in the community is associated with recognition of arrest, dispatcher-provided CPR instructions, and bystander CPR. METHODS: All emergency medical services (EMS)-treated adult OHCAs with cardiac etiology were enrolled between 2013 and 2015, excluding cases witnessed by EMS providers...
May 7, 2018: Resuscitation
https://www.readbyqxmd.com/read/29745476/clinical-impact-of-optical-coherence-tomography-findings-on-culprit-plaque-in-acute-coronary-syndrome-the-oct-formidable-study-registry
#19
Mario Iannaccone, Geraud Souteyrand, Giampaolo Niccoli, Massimo Mancone, Gennaro Sardella, Corrado Tamburino, Christian Templin, Sebastiano Gili, Giacomo G Boccuzzi, Fabrizio D'Ascenzo
BACKGROUND: Aim of this study was to evaluate the clinical impact of the culprit plaque features assessed by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). METHODS: The OCT-FORMIDABLE register enrolled retrospectively all consecutive patients who perform OCT on culprit plaque in patients with ACS in nine European centres. The primary endpoint was the prevalence of culprit plaque rupture (CPR) in patients experiencing major adverse cardiovascular events (MACEs)...
May 10, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29743764/definition-of-terms-used-in-limitation-of-treatment-and-providing-palliative-care-at-the-end-of-life-the-indian-council-of-medical-research-commission-report
#20
Naveen Salins, Roop Gursahani, Roli Mathur, Shivakumar Iyer, Stanley Macaden, Nagesh Simha, Raj Kumar Mani, M R Rajagopal
Background: Indian hospitals, in general, lack policies on the limitation of inappropriate life-sustaining interventions at the end of life. To facilitate discussion, preparation of guidelines and framing of laws, terminologies relating to the treatment limitation, and providing palliative care at the end-of-life care (EOLC) need to be defined and brought up to date. Methodology: This consensus document on terminologies and definitions of terminologies was prepared under the aegis of the Indian Council of Medical Research...
April 2018: Indian Journal of Critical Care Medicine
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