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Post Concussion

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https://www.readbyqxmd.com/read/28338593/clinical-correlates-to-assist-with-cte-diagnosis-insights-from-a-novel-rodent-repeat-concussion-model
#1
Gretchen M Thomsen, Ara Ko, Megan Y Harada, Annie Ma, Livia Wyss, Patricia Haro, Jean-Philippe Vit, Pablo Avalos, Navpreet Dhillon, Noell Cho, Oksana Shelest, Eric J Ley
INTRODUCTION: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries. CTE symptoms include changes in mood, behavior, cognition and motor function, however CTE is only currently diagnosed post-mortem. Using a rat model of recurrent traumatic brain injury (TBI) we demonstrate rodent deficits that predict the severity of CTE-like brain pathology. METHODS: Bilateral, closed skull, mild TBI was administered once per week to 35 WT rats, 8 rats received 2 injuries ('2xTBI'), 27 rats received 5 injuries ('5xTBI') and 13 rats were sham controls...
March 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28334382/concussion-like-symptom-reporting-in-non-concussed-collegiate-athletes
#2
Breton M Asken, Aliyah R Snyder, James R Clugston, Leslie S Gaynor, Molly J Sullan, Russell M Bauer
Objective: Non-concussed individuals may report a variety of concussion-like symptoms even in the absence of a diagnosed brain injury. Previous studies described concussion-like symptom reporting in adolescent athletes. This study provides complementary data on concussion-like symptoms in collegiate athletes. Methods: We analyzed baseline symptom scales from 738 collegiate athletes (452 men and 286 women) who completed either the Sport Concussion Assessment Tool, 3 Symptom Evaluation (S3SE; n = 377) or the Post-Concussion Scale (PCS; n = 361) and determined if subjects met criteria for diagnosis of International Classification of Diseases 10th Revision (ICD-10) postconcussional syndrome...
March 10, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28326857/depression-in-youth-recovering-from-concussion-correlates-and-predictors
#3
Kathy Stazyk, Carol DeMatteo, Sandra Moll, Cheryl Missiuna
OBJECTIVES: Although depression can be a serious consequence of concussion, little is known about the factors that predict depression and concussion recovery outcomes in children. The purpose of this study was to explore the risk and possible predictors of developing significant depressive symptoms in children recovering from concussion. METHODS: A prospective cohort study was conducted in a paediatric tertiary care clinic. Depression data were collected from 92 children using the Children's Depression Inventory-2 (CDI-2) screening tool...
March 22, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28324787/interactive-ebooks-in-educating-patients-and-their-families-about-head-injury-regardless-of-age
#4
Ronald Sahyouni, Amin Mahmoodi, Amir Mahmoodi, Melissa Huang, Diem Kieu Tran, Jefferson W Chen
OBJECTIVES: Traumatic Brain Injury (TBI) is a common and debilitating injury that is particularly prevalent in patients over 60. Given the influence of head injury on dementia (and vice versa), and the increased likelihood of ground-level falls, elderly patients are vulnerable to TBI. Educational interventions can increase knowledge and influence preventative activity to decrease the likelihood of further TBI. We sought to determine the efficacy of interactive tablet-based educational interventions in elderly patients on self-reported knowledge...
March 8, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28298170/concussion-induces-hippocampal-circuitry-disruption-in-swine
#5
John A Wolf, Brian N Johnson, Victoria E Johnson, Mary E Putt, Kevin D Browne, Constance J Mietus, Daniel P Brown, Kathryn L Wofford, Douglas H Smith, M Sean Grady, Akiva S Cohen, D Kacy Cullen
Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI), however the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following TBI using a model of head rotational acceleration that closely replicates the biomechanics and neuropathology of closed-head TBI in humans. We examined neurophysiological changes using a novel ex vivo hippocampal slice paradigm with extracellular stimulation and recording in the dentate gyrus and CA1 occurring at 7 days following non-impact inertial TBI in swine...
March 16, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28296510/multidisciplinary-outpatient-treatment-in-patients-with-mild-traumatic-brain-injury-a-randomised-controlled-intervention-study
#6
Eirik Vikane, Torgeir Hellstrøm, Cecilie Røe, Erik Bautz-Holter, Jörg Aßmus, Jan Sture Skouen
OBJECTIVE: To evaluate the efficacy of a multidisciplinary outpatient follow-up programme compared to follow-up by a general practitioner for patients being at-risk or sick-listed with persistent post-concussion symptoms two months after a mild traumatic brain injury. DESIGN: Randomised controlled trial. PATIENTS: One hundred fifty-one patients, 16-56 years. METHODS: Multidisciplinary outpatient rehabilitation with individual contacts and a psycho-educational group intervention at two outpatient rehabilitation clinics compared to follow-up by a general practitioner after the multidisciplinary examination...
March 15, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28293983/trajectories-and-risk-factors-for-posttraumatic-stress-symptoms-following-pediatric-concussion
#7
Katherine Truss, Celia Godfrey, Michael Takagi, Franz Babl, Silvia Bressan, Stephen J C Hearps, Cathriona Clarke, Kevin Dunne, Vicki Anderson
A substantial minority of children experience posttraumatic stress symptoms (PTSS) following injury. Research indicates variation in the trajectory of PTSS following pediatric injury, but investigation of PTSS following concussion has assumed homogeneity. This study aimed to identify differential trajectories of PTSS following pediatric concussion and to investigate risk-factors, including acute post-concussive symptoms (PCS), associated with these trajectories. 120 children aged 8-18 years reported PTSS for 3 months following concussion diagnosis using the Child PTSD Symptom Scale, with a score of 16 or above indicating probable PTSD diagnosis...
March 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28292694/asb-clinical-biomechanics-award-winner-2016-assessment-of-gaze-stability-within-24-48hours-post-concussion
#8
Nicholas G Murray, Nathan R D'Amico, Douglas Powell, Megan E Mormile, Katelyn E Grimes, Barry A Munkasy, Russell K Gore, Rebecca J Reed-Jones
BACKGROUND: Approximately 90% of athletes with concussion experience a certain degree of visual system dysfunction immediately post-concussion. Of these abnormalities, gaze stability deficits are denoted as among the most common. Little research quantitatively explores these variables post-concussion. As such, the purpose of this study was to investigate and compare gaze stability between a control group of healthy non-injured athletes and a group of athletes with concussions 24-48hours post-injury...
March 6, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28285252/anxiety-sensitivity-mediates-gender-differences-in-post-concussive-symptoms-in-a-clinical-sample
#9
Brian J Albanese, Joseph W Boffa, Richard J Macatee, Norman B Schmidt
Traumatic brain injury (TBI) is both prevalent and potentially disabling. Extant literature has demonstrated women to report greater post-concussive symptoms (PCS) compared to men, highlighting the necessity of investigations into malleable, gender-linked risk factors for PCS that hold promise for reducing this gender disparity. Anxiety Sensitivity (AS) and Distress Tolerance (DT) are gender-linked risk factors that may be related to PCS. Despite a breadth of research supporting elevated AS and reduced DT in women, no study to date has investigated whether AS and DT mediate gender differences in PCS...
March 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28283595/astroglial-activation-and-altered-amyloid-metabolism-in-human-repetitive-concussion
#10
Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kina Höglund, Erik Portelius, David L Brody, Kaj Blennow, Henrik Zetterberg
OBJECTIVE: To determine whether postconcussion syndrome (PCS) due to repetitive concussive traumatic brain injury (rcTBI) is associated with CSF biomarker evidence of astroglial activation, amyloid deposition, and blood-brain barrier (BBB) impairment. METHODS: A total of 47 participants (28 professional athletes with PCS and 19 controls) were assessed with lumbar puncture (median 1.5 years, range 0.25-12 years after last concussion), standard MRI of the brain, and Rivermead Post-Concussion Symptoms Questionnaire (RPQ)...
March 10, 2017: Neurology
https://www.readbyqxmd.com/read/28280686/the-first-week-after-concussion-blood-flow-brain-function-and-white-matter-microstructure
#11
Nathan W Churchill, Michael G Hutchison, Doug Richards, General Leung, Simon J Graham, Tom A Schweizer
Concussion is a major health concern, associated with short-term deficits in physical function, emotion and cognition, along with negative long-term health outcomes. However, we remain in the early stages of characterizing MRI markers of concussion, particularly during the first week post-injury when symptoms are most severe. In this study, 52 varsity athletes were scanned using Magnetic Resonance Imaging (MRI), including 26 athletes with acute concussion (scanned 1-7 days post-injury) and 26 matched control athletes...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28268423/dynamic-cerebral-autoregulation-in-young-athletes-following-concussion
#12
Kyriaki Kostoglou, Alexander D Wright, Jonathan D Smirl, Kelsey Bryk, Paul van Donkelaar, Georgios D Mitsis
The purpose of this study was to examine cerebral autoregulation (CA) in young athletes experiencing concussion. The subjects were monitored and repeatedly tested 72 hours, 2 weeks and 1 month post-injury. Mean arterial blood pressure (MABP), end-tidal partial pressure of carbon dioxide (PETCO2) and cerebral blood flow velocity (CBFV) in the middle and posterior cerebral arteries were monitored during mental activation paradigms. In order to characterize CA we employed autoregressive models with exogenous inputs (ARX) and impulse response models based on the Laguerre expansion technique (LET)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268276/preliminary-results-of-residual-deficits-observed-in-athletes-with-concussion-history-combined-eeg-and-cognitive-study
#13
Tamanna T K Munia, Jeffrey L Gendreau, Ajay K Verma, Benjamin D Johnson, Mark Romanick, Kouhyar Tavakolian, Reza Fazel-Rezai
Assessment, treatment, and management of sport-related concussions are a widely recognized public health issue. Although several neuropsychological and motor assessment tools have been developed and implemented for sports teams at various levels and ages, the sensitivity of these tests has yet to be validated with more objective measures to make return-to-play (RTP) decisions more confidently. The present study sought to analyze the residual effect of concussions on a sample of adolescent athletes who sustained one or more previous concussions compared to those who had no concussion history...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262355/the-importance-of-a-neck-exam-in-sport-related-concussion-cervical-schwannoma-in-post-concussion-syndrome
#14
David M Langelier, Kathryn J Schneider, John Hurlbert, Chantel T Debert
OBJECTIVE: Few cases of cervical schwannoma have been reported following head trauma. The present case, involves a schwannoma of the C2 spinal nerve mimicking post-concussion symptoms following a sport-related concussion (SRC). DESIGN: Case study. SETTING: University of Calgary, Sport Medicine Clinic, Calgary, Alberta, Canada. RESULTS: We report a 28 year old, athlete who developed headache, dizziness, photophobia, and neck pain following a cycling accident...
January 17, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28259770/a-prospective-investigation-of-changes-in-the-sensorimotor-system-following-sports-concussion-an-exploratory-study
#15
Julie A Hides, Melinda M Franettovich Smith, M Dilani Mendis, Nigel A Smith, Andrew J Cooper, Julia Treleaven, Felix Leung, Andrew J Gardner, Paul McCrory, Nancy L Low Choy
BACKGROUND: Sports concussion is a risk for players involved in high impact, collision sports. Post-concussion, the majority of symptoms subside within 7-10 days, but can persist in 10-20% of athletes. Understanding the effects of sports concussion on sensorimotor systems could inform physiotherapy treatment. OBJECTIVE: To explore changes in sensorimotor function in the acute phase following sports concussion. DESIGN: Prospective cohort study...
February 24, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28258820/the-king-devick-k-d-test-and-concussion-diagnosis-in-semi-professional-rugby-union-players
#16
John H Molloy, Ian Murphy, Conor Gissane
OBJECTIVES: To determine the utility of the King-Devick (K-D) test in identifying sports-related concussion in semi-professional rugby players. DESIGN: Descriptive cohort study. METHODS: 176 male players were recruited from a semi-professional rugby union competition in New Zealand (NZ). Baseline K-D scores were obtained in the pre-season. Post-match K-D and Pitch Side Concussion Assessment Version 2 (PSCA2) scores were obtained in those with suspected concussion...
February 28, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28250556/cascade-of-traumatic-brain-injury-a-correlational-study-of-cognition-postconcussion-symptoms-and-quality-of-life
#17
Rajakumari Pampa Reddy, Jamuna Rajeswaran, B Indira Devi, Thennarasu Kandavel
INTRODUCTION: Traumatic brain injury (TBI) constitutes a significant burden on health care resources in India. TBI is a dynamic process which involves damage to the brain thus leading to behavior cognitive and emotional consequences. AIM: To study the cognitive profile, post-concussion symptoms (PCS), quality of life (QOL), and their correlation. METHODS: A total of 60 patients with TBI were recruited and assessed for neuropsychological profile, PCS, and QOL, the correlation among the variables were analyzed...
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28243574/5-year-imaging-sequelae-of-concussive-blast-injury-and-relation-to-early-clinical-outcome
#18
Christine L Mac Donald, Jason Barber, Jalal Andre, Nicole Evans, Chris Panks, Samantha Sun, Kody Zalewski, R Elizabeth Sanders, Nancy Temkin
Current imaging diagnostic techniques are often insensitive to the underlying pathological changes following mild traumatic brain injury (TBI) or concussion so much so that the explicit definition of these uncomplicated mild brain injuries includes the absence of radiological findings. In the US military, this is complicated by the natural tendency of service members to down play symptoms for fear of removal from their unit particularly in combat making it challenging for clinicians to definitively diagnose and determine course of treatment...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28239838/which-matters-more-a-retrospective-cohort-study-of-headache-characteristics-and-diagnosis-type-in-soldiers-with-mtbi-concussion
#19
Alan G Finkel, Brian J Ivins, Juanita A Yerry, John S Klaric, Ann Scher, Y Sammy Choi
OBJECTIVE: To describe the diagnostic types and characteristics of headaches in soldiers with mild traumatic brain injury during the wars in Afghanistan and Iraq. BACKGROUND: Persistent post-traumatic headache interferes with returns to activity or duty. The most commonly cited headache diagnosis after concussion is migraine. We hypothesize that headache diagnosis type, eg, migraine, is not sufficient to predict relationships with occupational outcomes after concussion...
February 27, 2017: Headache
https://www.readbyqxmd.com/read/28228043/impact-of-exercise-on-clinical-symptom-report-and-neurocognition-after-concussion-in-children-and-adolescents
#20
Vicky Manikas, Franz E Babl, Stephen Hearps, Julian Dooley, Vicki Anderson
Recovery from concussion in childhood is poorly understood, despite its importance in decisions regarding return to normal activity. Resolution of post-concussive symptoms (PCS) is widely employed as a marker of recovery in clinical practice; however, it is unclear whether subtle impairments persist only to re-emerge in the context of increased physical or cognitive demands. This study aimed to examine the effect of strenuous exercise on clinical symptom report and neurocognition in children and adolescents after PCS resolution after concussion...
March 21, 2017: Journal of Neurotrauma
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