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Post Concussion

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https://www.readbyqxmd.com/read/28989074/safety-of-active-rehabilitation-for-persistent-symptoms-after-pediatric-sport-related-concussion-a-randomized-controlled-trial
#1
Catherine Chan, Grant L Iverson, Jacqueline Purtzki, Kathy Wong, Vivian Kwan, Isabelle Gagnon, Noah D Silverberg
OBJECTIVE: To examine the safety and tolerability of an active rehabilitation program for adolescents who are slow to recover from a sport-related concussion. A secondary objective was to estimate the treatment effect for this intervention. DESIGN: Single-site parallel open-label randomized controlled trial (RCT) comparing treatment as usual (TAU) to TAU plus active rehabilitation. SETTING: Outpatient concussion clinic. PARTICIPANTS: Adolescents aged 12-18 with postconcussion symptoms lasting >1 month after a sports-related concussion...
October 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28986325/an-emotional-go-no-go-fmri-study-in-adolescents-with-depressive-symptoms-following-concussion
#2
Rachelle A Ho, Geoffrey B Hall, Michael D Noseworthy, Carol DeMatteo
BACKGROUND: Following concussion, adolescents may experience both poor inhibitory control and increased depressive symptoms. fMRI research suggests a physiological difference between patients with clinical depression and patients with depressive symptoms after concussion. The scarcity of information surrounding depression following concussion in youth makes it difficult to identify patients at risk of depression after injury. This is the first study to examine neural activity patterns in adolescents with post-concussive depressive symptoms...
October 3, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28982552/repetitive-head-impacts-do-not-affect-postural-control-following-a-competitive-athletic-season
#3
Nicholas G Murray, Katelyn E Grimes, Eric D Shiflett, Barry A Munkasy, Nathan R D'Amico, Megan E Mormile, Douglas W Powell, Thomas A Buckley
Evidence suggests that Repetitive Head Impacts (RHI) directly influence the brain over the course of a single contact collision season yet do not significantly impact a player's performance on the standard clinical concussion assessment battery. The purpose of this study was to investigate changes in static postural control after a season of RHI in Division I football athletes using more sensitive measures of postural control as compared to a non-head contact sports. Fourteen Division I football players (CON) (age=20...
October 2, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28980825/does-the-fear-avoidance-model-explain-persistent-symptoms-after-traumatic-brain-injury
#4
Melloney L M Wijenberg, Sven Z Stapert, Jeanine A Verbunt, Jennie L Ponsford, Caroline M Van Heugten
BACKGROUND: A minority of patients with mild traumatic brain injury (mTBI) experience a persistent symptom complex also known as post-concussion syndrome. Explanations for this syndrome are still lacking. OBJECTIVE: To investigate if the fear avoidance model, including catastrophizing thoughts and fear avoidance behaviour, poses a possible biopsychosocial explanation for lingering symptoms and delay in recovery after traumatic brain injury (TBI) with special focus on mTBI...
October 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28979609/examining-microstructural-white-matter-in-active-duty-soldiers-with-a-history-of-mild-traumatic-brain-injury-and-traumatic-stress
#5
Michael N Dretsch, Rael T Lange, Jeffery S Katz, Adam Goodman, Thomas A Daniel, Gopikrishna Deshpande, Thomas S Denney, Grant L Iverson, Jennifer L Robinson
BACKGROUND: There is a high comorbidity of posttraumatic stress (PTS) and mild traumatic brain injury (mTBI), with largely overlapping symptomatology, in military service members. OBJECTIVE: To examine white matter integrity associated with PTS and mTBI as assessed using diffusion tensor imaging (DTI). METHOD: Seventy-four active-duty U.S. soldiers with PTS (n = 16) and PTS with co-morbid history of mTBI (PTS/mTBI; n = 28) were compared to a military control group (n = 30)...
2017: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/28969486/prognostic-value-of-s-100%C3%A3-protein-for-prediction-of-post-concussion-symptoms-following-a-mild-traumatic-brain-injury-systematic-review-and-meta-analysis
#6
Eric Mercier, Pier-Alexandre Tardif, Peter Cameron, Brice Lionel Batomen Kuimi, Marcel Émond, Lynne Moore, Biswadev Mitra, Jérôme Frenette, Elaine de Guise, Marie-Christine Ouellet, Martine Bordeleau, Natalie Le Sage
This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms following a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patient data were requested. Cohort studies evaluating the association between S-100β protein level and post-concussion symptoms assessed at least seven days after the mTBI were considered. Outcomes were dichotomised as persistent (>= 3 months) or early (>= 7 days < 3 months)...
October 2, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28967326/cerebral-blood-flow-after-mild-traumatic-brain-injury-associations-between-symptoms-and-post-injury-perfusion
#7
Jaclyn A Stephens, Peiying Liu, Hanzang Lu, Stacy J Suskauer
Arterial spin labeling (ASL) has emerged as a technique for assessing mild traumatic brain injury (mTBI), as it can non-invasively evaluate cerebrovascular physiology. To date, there is substantial variability in methodology and findings of ASL studies of mTBI. While both increased and decreased perfusion are reported after mTBI, more consistency is emerging when perfusion is examined with regard to symptomology. We evaluated 15 teenage athletes 2 and 6 weeks after sports-related concussion (SRC group) using pseudo-continuous ASL...
October 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28963310/characteristics-of-patients-included-and-enrolled-in-studies-on-the-prognostic-value-of-serum-biomarkers-for-prediction-of-postconcussion-symptoms-following-a-mild-traumatic-brain-injury-a-systematic-review
#8
Eric Mercier, Pier-Alexandre Tardif, Marcel Emond, Marie-Christine Ouellet, Élaine de Guise, Biswadev Mitra, Peter Cameron, Natalie Le Sage
OBJECTIVE: Mild traumatic brain injury (mTBI) has been insufficiently researched, and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalisability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes, but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that evaluated the prognostic value of protein biomarkers to predict postconcussion symptoms following an mTBI...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28961684/validity-and-reliability-of-baseline-testing-in-a-standardized-environment
#9
Kathryn L Higgins, Todd Caze, Arthur Maerlender
Objective: The Immediate Postconcussion Assessment and Cognitive Testing (ImPACT) is a computerized neuropsychological test battery commonly used to determine cognitive recovery from concussion based on comparing post-injury scores to baseline scores. This model is based on the premise that ImPACT baseline test scores are a valid and reliable measure of optimal cognitive function at baseline. Growing evidence suggests that this premise may not be accurate and a large contributor to invalid and unreliable baseline test scores may be the protocol and environment in which baseline tests are administered...
August 11, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28954796/comparison-of-amateur-boxing-before-and-after-the-2013-rules-change-and-the-impact-on-boxers-safety
#10
Philip Davis, Robert Waldock, Andrew Connorton, Sonny Driver, Sean Anderson
OBJECTIVES: The effect of the rules change in 2013 on amateur boxing strategy, technique and safety in comparison with pre-2013 is unknown. METHODS: Pre-2013 and post-2013 3×3 min elite level amateur boxing was compared from video footage of 29 Olympic (pre-2013) and 50 World Championship bouts (post-2013) totalling 99 male boxers (mean±SD) age: 24.3±3.2 years, height: 177.3±11.3 cm and body mass: 70.7±16.4 kg. RESULT: Many techniques that were dominant pre-2013 were used less post-2013, including: total punches thrown, rear hand punches, hook rear hand, punches landed, uppercut punches, total punches to the body (all <0...
September 27, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28952858/sub-symptomatic-aerobic-exercise-for-patients-with-post-concussion-syndrome-a-critically-appraised-topic
#11
Katrina G Ritter, Matthew J Hussey, Tamara C Valovich McLeod
Clinical Scenario: Patients who experience prolonged concussion symptoms can be diagnosed with Post-Concussion Syndrome (PCS) when those symptoms persist past 4 weeks. Aerobic exercise protocols have been shown to be effective in improving physical and mental aspects of health. Emerging research suggests that aerobic exercise maybe useful as a treatment for PCS, where exercise allows patients to feel less isolated and more active during the recovery process. CLINICAL QUESTION: Is aerobic exercise more beneficial in reducing symptoms than current standard care in patients with prolonged symptoms or PCS lasting longer than 4 weeks? Summary of Key Findings: After a thorough literature search, 4 studies were selected relevant to the clinical question...
September 27, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28942673/concussion-nondisclosure-during-professional-career-among-a-cohort-of-former-national-football-league-athletes
#12
Zachary Y Kerr, Johna K Register-Mihalik, Melissa C Kay, J D DeFreese, Stephen W Marshall, Kevin M Guskiewicz
BACKGROUND: Despite a focus on the incidence and effects of concussion, nondisclosure of sports-related concussions among retired players from the National Football League (NFL) has yet to be examined. PURPOSE: Examine the prevalence of and factors associated with nondisclosure of sports-related concussions in former NFL athletes. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: A sample of 829 former NFL players completed a general health survey...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28939003/factors-associated-with-post-concussion-syndrome-in-high-school-student-athletes
#13
Zachary Y Kerr, Scott L Zuckerman, Erin W Wasserman, Christina B Vander Vegt, Aaron Yengo-Kahn, Thomas A Buckley, Gary S Solomon, Allen K Sills, Thomas P Dompier
OBJECTIVES: To identify factors associated with post-concussion syndrome (PCS) among a national sample of high school student-athletes from the 2011/12-2013/14 academic years. DESIGN: Ambispective cohort study from sports injury surveillance data. METHODS: Sport-related concussion data originated from the National Athletic Treatment, Injury and Outcomes Network (NATION) surveillance program, consisting of 27 sports from a convenience sample of 196 high schools across 26 states...
September 14, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28927553/self-report-balance-status-is-not-reliable-post-concussion
#14
EDITORIAL
Gordon S Waddington
No abstract text is available yet for this article.
November 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28926944/coach-cv-the-seven-clinical-phenotypes-of-concussion
#15
Neil Craton, Haitham Ali, Stephane Lenoski
Our understanding of the diverse physiological manifestations of concussion is changing rapidly. This has an influence on the clinical assessment of patients who have sustained a concussion. The 2017 Consensus Statement on Concussion in Sport states that numerous post-injury clinical findings, such as cognitive deficits, post-traumatic headaches, dizziness, difficulties with oculomotor function, and depression have all been associated with a poorer prognosis in concussed patients. This demonstrates that there are several potential clinical manifestations after head injury warranting clinical evaluation...
September 16, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28926482/is-there-an-optimal-time-to-initiate-an-active-rehabilitation-protocol-for-concussion-management-in-children-a-case-series
#16
Danielle M Dobney, Lisa Grilli, Helen Kocilowicz, Christine Beaulieu, Meghan Straub, Debbie Friedman, Isabelle J Gagnon
OBJECTIVE: To estimate the time frame during which initiating an active rehabilitation intervention (aerobic exercise, balance, and sport specific skills) after concussion contributed to improvement in symptoms at follow-up in children and adolescents who are slow to recover (symptoms persisting beyond 2 weeks) from concussion. SETTING: Concussion clinic at a tertiary care pediatric teaching hospital. PARTICIPANTS: A total of 677 children and adolescents with concussion aged 7 to 18 years...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28925734/a-pilot-treatment-study-for-mild-traumatic-brain-injury-neuroimaging-changes-detected-by-meg-after-low-intensity-pulse-based-transcranial-electrical-stimulation
#17
Ming-Xiong Huang, Ashley Robb Swan, Annemarie Angeles Quinto, Scott Matthews, Deborah L Harrington, Sharon Nichols, Barry J Bruder, Corey C Snook, Charles W Huang, Dewleen G Baker, Roland R Lee
BACKGROUND: Mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members, Veterans, and civilians. However, few treatments are available for mTBI, partially because the mechanism of persistent mTBI deficits is not fully understood. METHODS: We used magnetoencephalography (MEG) to investigate neuronal changes in individuals with mTBI following a passive neurofeedback-based treatment programme called IASIS. This programme involved applying low-intensity pulses using transcranial electrical stimulation (LIP-tES) with electroencephalography monitoring...
September 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28924170/the-tyrosine-phosphatase-ptpn13-fap-1-links-calpain-2-tbi-and-tau-tyrosine-phosphorylation
#18
Yubin Wang, Randy A Hall, Moses Lee, Andysheh Kamgar-Parsi, Xiaoning Bi, Michel Baudry
Traumatic brain injury (TBI) increases the risk of Alzheimer's disease (AD). Calpain activation and tau hyperphosphorylation have been implicated in both TBI and AD. However, the link between calpain and tau phosphorylation has not been fully identified. We recently discovered that the two major calpain isoforms in the brain, calpain-1 and calpain-2, play opposite functions in synaptic plasticity and neuronal survival/death, which may be related to their different C-terminal PDZ binding motifs. Here, we identify the tyrosine phosphatase PTPN13 as a key PDZ binding partner of calpain-2...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28918391/genetic-polymorphisms-associated-with-the-risk-of-concussion-in-1056-college-athletes-a-multicentre-prospective-cohort-study
#19
Thomas Roland Terrell, Ruth Abramson, Jeffery T Barth, Ellen Bennett, Robert C Cantu, Richard Sloane, Daniel T Laskowitz, David M Erlanger, Douglas McKeag, Gregory Nichols, Verle Valentine, Leslie Galloway
BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser(53)Pro, MAPT/tau Hist(47)Tyr, IL-6572 G/C and IL-6R(Asp)358(Ala) with the risk of concussion in college athletes. METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion...
September 16, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28895491/preliminary-validation-of-the-whodas-2-0-for-mild-traumatic-brain-injury
#20
Deborah Snell, Grant L Iverson, William Panenka, Noah D Silverberg
The purpose of this study is to examine the reliability, factor structure, and validity of the World Health Organization Disability Assessment Schedule (WHODAS 2.0 12-item version) in a sample of patients who were slow to recover from a mild traumatic brain injury (MTBI). Participants were 79 adults with MTBI recruited from one of four specialty outpatient clinics in Vancouver, Canada. The WHODAS 2.0 12-item version is a disease-non-specific measure of disability representing six International Classification of Disability, Functioning, and Health activity and participation domains including cognition, mobility, self-care, interpersonal functioning, life activities, and participation...
September 12, 2017: Journal of Neurotrauma
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