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S Marchetta, R Dulgheru, C Oury, F Frippiat, P Lancellotti
Infective endocarditis is a rare disease that can lead to some diagnostic wandering because of its often nonspecific and polymorphic clinical manifestations. This latency is at the origin of severe cardiac and extra-cardiac complications, yet highly fatal. The clinician should always bear in mind the differential diagnosis of a patient with fever of undetermined origin, with risk factors for valve infection such as foreign material, and history recent invasive procedures (including dental procedures) or recent hospitalization...
May 2018: Revue Médicale de Liège
Amer Harky, Alexander Hof, Megan Garner, Saied Froghi, Mohamad Bashir
OBJECTIVE: The objective of this study is to review the morbidity and mortality associated with mitral valve repair versus replacement in infective endocarditis patients. METHODS: A comprehensive search was undertaken among the four major databases (PubMed, Embase, Scopus, and Ovid) to identify all available data comparing mitral valve repair or replacement in infective endocarditis. Databases were evaluated and assessed to March 2017. Data were analyzed using meta-analytical techniques including odds ratio and mean weighted difference...
June 21, 2018: Journal of Cardiac Surgery
Iacovelli Alessandra, Spaziante Martina, Al Moghazi Samir, Giordano Alessandra, Ceccarelli Giancarlo, Venditti Mario
INTRODUCTION: The emergence of carbapenemase-producing Klebsiella pneumonia (KPC-Kp) has become a significant problem in terms of public health and clinical outcome in many hospitals in Southern Europe. Treatment options are usually limited and effective treatment of infections caused by these pathogens is a considerable challenge for clinicians. Ceftazidime-avibactam has been recently approved for the treatment of difficult-to-treat infections due to aerobic Gram-negative organisms in patients with limited treatment options...
June 20, 2018: Infection
Vance G Nielsen, Paul M Ford
Aminocaproic acid (EACA) availability has recently been decreased whereas tranexamic acid (TXA) is still available as an antifibrinolytic agent to decrease blood loss associated with procedures involving cardiopulmonary bypass (CPB) by inhibiting plasmin mediated platelet activation. Given that the clinical inclination is to substitute TXA for EACA, we sought to compare the antifibrinolytic efficacy of the two agents using the clinically accepted molar ratio of EACA:TXA (7.9:1) that prevents platelet activation in a viscoelastic based system under a variety of conditions in human plasma; 25-50% therapeutic concentration (EACA 32...
June 20, 2018: Journal of Thrombosis and Thrombolysis
Linda W Njoroge, Sadeer G Al-Kindi, George Augustine Koromia, Chantal A ElAmm, Guilherme H Oliveira
No abstract text is available yet for this article.
June 20, 2018: JAMA Cardiology
David J Murphy, Munaib Din, Fadi G Hage, Eliana Reyes
Over recent years, new evidence has led a rethinking of the available guidance on the diagnosis and management of infective endocarditis (IE). This review compares the most recently available guidance provided by the American Heart Association (AHA) IE Writing Committee, and the Task Force for the management of IE of the European Society of Cardiology (ESC). This represents the sixth of a new series of comparative guidelines review published in the Journal.
June 19, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Maha Jahangir, Marrium Nawaz, Fareha Jabbar, Fahad Khan, Nimra Hasnain
Atrial septal defect (ASD) is a common congenital abnormality, which accounts for 20-40% of all the adult patients with congenital heart diseases. Due to the slow velocity of shunt flow, ASD has a negligible risk for infective endocarditis (IE). However, intravenous drug abuse (IVDA) is a potential cause for IE. IE remains a diagnostic and therapeutic challenge. Our case report demonstrates the atypical presentation of IE in an ASD patient. The diagnosis was made on the basis of modified Duke criteria, and blood cultures were found out to be positive for methicillin-resistant Staphylococcus aureus (MRSA)...
April 15, 2018: Curēus
Avnish Tripathi, Yinding Wang, Jeanette M Jerrell
Background: We investigated the treated prevalence of bicuspid aortic valve in a pediatric population with congenital heart disease and its incident complications. Materials and Methods: A 15-year retrospective data set was analyzed. Selection criteria included age ≤17 years, enrollees in the South Carolina State Medicaid program and diagnosed as having bicuspid aortic valve on one or more service visits. Results: The 15-year-treated prevalence of predominantly isolated bicuspid aortic valve was 2% (20/1000) of pediatric congenital heart disease cases, with a non-African American: African-American ratio of 3...
May 2018: Annals of Pediatric Cardiology
Andrew D Wiese, Marie R Griffin, C Michael Stein, William Schaffner, Robert A Greevy, Edward F Mitchel, Carlos G Grijalva
OBJECTIVES: Hospitalisations for serious infections are common among middle age and older adults and frequently used as study outcomes. Yet, few studies have evaluated the performance of diagnosis codes to identify serious infections in this population. We sought to determine the positive predictive value (PPV) of diagnosis codes for identifying hospitalisations due to serious infections among middle age and older adults. SETTING AND PARTICIPANTS: We identified hospitalisations for possible infection among adults >=50 years enrolled in the Tennessee Medicaid healthcare programme (2008-2012) using International Classifications of Diseases, Ninth Revision diagnosis codes for pneumonia, meningitis/encephalitis, bacteraemia/sepsis, cellulitis/soft-tissue infections, endocarditis, pyelonephritis and septic arthritis/osteomyelitis...
June 19, 2018: BMJ Open
Harold L Lazar
No abstract text is available yet for this article.
June 19, 2018: Journal of Cardiac Surgery
Christine F Klein, Sanne Gørtz, Jan Wohlfahrt, Tina N Munch, Mads Melbye, Henning Bundgaard, Kasper K Iversen
Background: The present study aimed to investigate the long-term risk of hemorrhagic stroke (HS) in patients with infective endocarditis (IE). Methods: Using a register-based nationwide cohort of 9 million Danes, we propensity score-matched patients with left-sided IE from 1977 to mid-2015 with IE-free individuals (1:10). Follow up started one year after the IE diagnosis. Hazard ratios (HRs) for HS in IE patients compared to the matched cohort were estimated using Cox regression...
June 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Stina Jordal, Bård Reiakvam Kittang, Pirjo-Riitta Salminen, Geir Egil Eide, Øyvind Kommedal, Øystein Wendelbo, Rune Haaverstad, Haakon Sjursen
BACKGROUND: To investigate epidemiological trends of infective endocarditis (IE) in western Norway a retrospective study was performed. METHODS: Characteristics of 706 IE admissions from 1996 to 2005 and 2006 to 2015 were analysed and compared using the Chi-square test for categorical variables and the t-test for age. Survival was analysed by multiple Cox regression and reported by the hazard ratio (HR). RESULTS: Mean annual incidence rates increased from 4...
June 19, 2018: Infectious Diseases
Sijan Basnet, Niranjan Tachamo, Rashmi Dhital, Biswaraj Tharu
Daptomycin is a bactericidal antibiotic approved for treatment of gram-positive skin and soft tissue infections. We present a case of an 89-year-old man who presented with fever, shortness of breath and nonproductive cough on week 4 of starting daptomycin for infective endocarditis. Computerized tomography scan showed bilateral interstitial infiltrates predominantly affecting the lower lobes. He also had peripheral eosinophilia of 6%. He was diagnosed with eosinophilic pneumonia secondary to daptomycin use...
2018: Journal of Community Hospital Internal Medicine Perspectives
Zubair Khan, Nauman Siddiqui, Muhammad Wasif Saif
Mostly Streptococcus bovis ( S. bovis ) bacteremia and endocarditis (60%) has been found to be associated with underlying colorectal cancer (CRC). Enterococcus faecalis ( E. faecalis ) bacteremia and endocarditis has no identifiable source in most of the cases. E. faecalis is part of normal gut flora that can translocate through the intestine and cause the systemic infection. With any intestinal lesion or tumor, the barrier is breached and the gut flora like E. faecalis can translocate and cause infection. A 55-years-old male known to have non-ischemic cardiomyopathy with implantation of automated implantable cardioverter defibrillator (AICD) and atrial fibrillation presented with weight loss, fever and back pain...
June 2018: Gastroenterology Research
Geneviève LeBel, Katy Vaillancourt, Li Yi, Marcelo Gottschalk, Daniel Grenier
Streptococcus suis is a major swine pathogen causing pathologies such as meningitis, sepsis, endocarditis, and arthritis. Several surface-bound and secreted proteases produced by S. suis have been identified and proposed as virulence factors. PR-39 is a proline/arginine-rich antimicrobial peptide produced by porcine leucocytes. In addition to play a role in innate immunity, this peptide possesses immunomodulatory properties. In this study, we hypothesized that proteases produced by S. suis inactivate PR-39...
June 15, 2018: Microbial Pathogenesis
Bobby Yanagawa, Amine Mazine, Derrick Y Tam, Peter Jüni, Deepak L Bhatt, Stephen Spindel, John D Puskas, Subodh Verma, Jan O Friedrich
OBJECTIVE: Surgical management of aortic valve infective endocarditis (IE) with cryopreserved homograft has been associated with lower risk of recurrent IE, but there is equipoise with regard to the optimal prosthesis. This systematic review and meta-analysis were performed to compare outcomes between homograft and conventional prosthesis for aortic valve IE. METHODS: We searched MEDLINE database to September 2017 for studies comparing homograft versus conventional prosthesis...
June 15, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Laurens E Swart, Jolien W Roos-Hesselink, Roelf Valkema, Carolina A M Schurink, Ricardo P J Budde
No abstract text is available yet for this article.
June 14, 2018: European Heart Journal Cardiovascular Imaging
Daniele De Viti, Francesco Santoro, Pasquale Raimondo, Natale Daniele Brunetti, Cataldo Memmola
We report a late clinical presentation of an aorto-right ventricular fistula (RVF) extending from the right sinus of Valsalva into the RV outflow tract with significant left-to-right shunt and severe pulmonary hypertension. A three-dimensional transesophageal echocardiogram and a chest-computed tomography scans were performed to better characterize the abnormality. Aorto- RVF can be either congenital or acquired, secondary to endocarditis, Valsalva aneurysm rupture, chest trauma, or aortic dissection.
April 2018: Journal of Cardiovascular Echography
Veysel Tosun, Necmettin Korucuk, Unal Guntekin
Sinus of valsalva aneurysm (SVA) is a rare cardiac disease. The most common complication of SVA is rupture into the right atrium or right ventricle. Rupture into the left chambers is very rare. Patients with ruptured SVA are likely to die of heart failure or endocarditis. We present a 29-year-old man who was hospitalized for hepatic transplantation with rupture of SVA. Transthoracic echocardiography and transesophageal echocardiography showed rupture of a noncoronary SVA into the left atrium. Mitral valve infective endocarditis developed and surgery was planned for the patient, but the patient died due to multiple organ dysfunction syndrome...
April 2018: Journal of Cardiovascular Echography
Rita Leonarda Musci, Cataldo Girasoli, Fabrizio Fumarola, Carlo D'Agostino, Paolo Colonna
In recent years, with an increasing number of central venous access procedures and cardiac implantable electronic device implantation, the incidence of infective endocarditis (IE) has become more prevalent. Two-dimensional transthoracic echocardiography (2D-TTE) and transesophageal echocardiography (TEE) are a key part of the evaluation of IE, but advances in three-dimensional echocardiography have enabled a better spatial resolution and visualization of cardiac structures, allowing the identification of any valvular vegetations, abscesses, or nodules...
April 2018: Journal of Cardiovascular Echography
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