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tumor of the follicular infundibulum

Keisuke Goto
BACKGROUND: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors. METHODS: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues. RESULTS: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum...
August 10, 2016: Journal of Cutaneous Pathology
Ayse Serap Karadag, Emin Ozlu, Tugba Kevser Uzuncakmak, Necmettin Akdeniz, Bengu Cobanoglu, Berkant Oman
Inverted follicular keratosis is a rare benign tumor of the follicular infundibulum characterized by exo-endophytic growing. It is thought to be a rare variant of the seborrheic keratosis. The diagnosis of inverted follicular keratosis is generally established histopathologically because clinical differentiation from other lesions is difficult. Herein, we present one such rare case, successfully treated with topical 5% imiquimod cream.
May 2016: Indian Dermatology Online Journal
Oscar Tellechea, José Carlos Cardoso, José Pedro Reis, Leonor Ramos, Ana Rita Gameiro, Inês Coutinho, António Poiares Baptista
Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms...
November 2015: Anais Brasileiros de Dermatologia
Poonkiat Suchonwanit, Panunee Ruangchainikom, Yingluck Apibal
BACKGROUND: Tumor of the follicular infundibulum (TFI) is considered as a rare benign neoplasm providing two distinctive clinical patterns: the solitary and the eruptive form. The clinical presentations resemble many other dermatologic conditions and require histopathological study to make a definite diagnosis. OBJECTIVE: To inform physicians of a clinical presentation of TFI. CASE REPORT: We report on a 50-year-old man who presented with multiple asymptomatic hypopigmented macules resistant to the treatments...
September 2015: Dermatology and Therapy
Emilie Dore, Megan H Noe, Brian L Swick
Herein, we describe a 63-year-old male with multiple tumors arising within a nevus sebaceus on the posterior scalp. On histopathologic examination, four distinct tumors were identified: trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum (TFI). Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin-stained sections, imparting a signet-ring appearance to the cells...
September 2015: Journal of Cutaneous Pathology
Jian-Wei Zhu, Min Zheng, Zhong-Fa Lu
The etiology of tumor of the follicular infundibulum (TFI) is unknown. Eruptive forms of TFI are rare. We present the case of a 49-year-old woman with multiple lesions on the arms, shoulders, trunk, buttocks, and legs of more than 3 years' duration. On clinical and histologic examination, a diagnosis of multiple TFI was made. Additionally, the patient presented with other rare remarkable features including severe pruritus, the Köbner phenomenon, and underlying inflammatory cell infiltration of the tumors. These findings strongly suggest that eruptive TFI may represent a kind of cutaneous reaction...
December 2014: Cutis; Cutaneous Medicine for the Practitioner
Natalie Haddad, Jayme de Oliveira Filho, Mariana Junqueira Lacerda Reis, Alexandre Ozores Michalany, Kassila da Rosa Nasser, Ana Maria França Corbett
Tumor of the follicular infundibulum is a rare benign cutaneous adnexal neoplasm with variable clinical presentation. In most cases the diagnosis is made with the help of histopathology, due to lack of a characteristic clinical presentation. The most common form is a solitary lesion, but it can be multiple or eruptive, then called infundibulomatose. This case report illustrates a patient with multiple lesions of tumor of the follicular infundibulum with bizarre aspect and atypical location.
November 2014: Anais Brasileiros de Dermatologia
Katherine L Baquerizo Nole, Dan R Lopez-Garcia, Daniel J Teague, Ahmed Al Sayyah, Parisa Mansoori, Hamza Salim Al Alshehri, Omar P Sangüeza
Tumor of follicular infundibulum (TFI) is currently believed to be a benign epithelial neoplasm with follicular differentiation. It has been suggested that TFI is associated with dermal scarring, but further investigation is needed to confirm this correlation. To approach this question, a retrospective study was presented, a total of 67 cases (64 lesions) were found in a search covering cases over a 10-year period. Overall, the presence of histological dermal scarring was noted in 34 of 64 (53.13%) cases. Of the cases where TFI was an incidental finding, the presence of dermal scarring was noted in 13 of 18 (72...
July 2015: American Journal of Dermatopathology
Asha Kubba, Meenakshi Batrani, Atul Taneja, Vivek Jain
We present three cases of a rare eruptive variant of tumor of follicular infundibulum. Two patients presented with hypopigmented macules. The clinical differential diagnoses considered in these two cases were vitiligo, lichen sclerosus et atrophicus, and idiopathic guttate hypomelanosis. In the third case, the lesions were hypopigmented flat topped maculo-papules diagnosed clinically as verruca plana. In all three cases, the histopathological features of plate like growth of pale keratinocytes connected to the epidermis and peritumoral condensation of elastic fibers were diagnostic...
March 2014: Indian Journal of Dermatology, Venereology and Leprology
Serap Gozel, Melahat Donmez, Noyan Can Akdur, Hulya Yikilkan
Nevus sebaceus of Jadassohn is a congenital cutaneous hamartoma comprised of multiple skin structures. It has the potential to develop into variety of neoplasms of various epidermal adnexal origins. While multiple tumors may occasionally arise, it is unusual for more than four tumors to arise simultaneously within a single sebaceus nevus. Here in, we report a case of a 70-year-old woman with six neoplastic proliferations including a syringocystadenoma papilliferum, pigmented trichoblastoma, tubular apocrine adenoma, sebaceoma, tumors of follicular infundibulum and superficial epithelioma with sebaceus differentiation arising in a long standing nevus sebaceus on the scalp...
December 2013: Korean Journal of Pathology
Ahmed Alomari, Antonio Subtil, Cindy E Owen, Jennifer M McNiff
BACKGROUND: Tumor of the follicular infundibulum (TFI) is an uncommon benign adnexal tumor that usually presents as a solitary keratotic papule in the head and neck area. Infrequently, it may present as multiple lesions or in association with other conditions. Although it was initially described in 1961, the pathogenesis of this lesion is still controversial. METHODS: The clinical and histologic features of 168 cases of TFI were reviewed. Random cases were stained with elastic Van Gieson, cytokeratin (CK)20 and Ber-EP4...
June 2013: Journal of Cutaneous Pathology
Frederick A Jakobiec, Fouad R Zakka, Nancy Kim
An 86-year-old woman slowly developed a solitary 0.3 3 0.2-cm papule on the left lower eyelid. Complete excision disclosed a honeycombed lesion composed of interlacing basaloid strands unattached to the epidermis but rather extending into the dermis from a dilated hair follicle. The diagnosis was a solitary basaloid follicular hamartoma that can also occur in multiple, generalized, and inherited forms, sometimes with an associated systemic disease. The lesion exhibited a distinctive CD34-positive, mildly cellular myxoid stroma with many CK20-positive Merkel cells scattered within the basaloid cellular strands, which exhibited BCL-2 positivity only within the outermost cells bordering the stroma...
September 2012: Ophthalmic Plastic and Reconstructive Surgery
Athanassios Kolivras, Isabelle Moulonguet, Beth S Ruben, Ursula Sass, Letizia Cappelletti, Josette André
We report two cases of eruptive tumors of the follicular infundibulum (TFI) with an unusual clinical presentation which has not been described previously in literature. In both cases, the appearance was strikingly similar, consisting of multiple asymptomatic hypopigmented macules on the buttocks of two Black African males, aged 38 and 55 years old. In both cases, the eruption had evolved over several months. The individual lesions were of similar size, approximately 1 cm, with irregular and ill-defined borders...
April 2012: Journal of Cutaneous Pathology
Elena González-Guerra, Heinz Kutzner, Arno Rutten, Luis Requena
Calretinin is a calcium-binding protein member of the EF-hand family. The presence of calretinin has been demonstrated in certain stages of the cellular cycle in a wide variety of normal and neoplastic tissues. The main aims of our study were (1) to investigate what structures of the normal skin and cutaneous adnexal proliferations express immunoreactivity for calretinin and (2) to determine the value of immunohistochemical expression for calretinin as a marker for follicular, sebaceous, apocrine, and eccrine differentiation in cutaneous adnexal proliferations...
July 2012: American Journal of Dermatopathology
Deok-Woo Lee, Ji-Hye Yang, Hyung-Min Lee, Chong-Hyun Won, Sungeun Chang, Mi-Woo Lee, Jee-Ho Choi, Kee-Chan Moon
Tumor of the follicular infundibulum (TFI) is an uncommon benign adnexal tumor that usually presents as a solitary keratotic papule on the face or scalp of elderly patients. Histopathologically, it typically manifests as a plate-like fenestrated proliferation of monomorphic pale-staining cells. A 76-year-old male presented with about a 2 cm, well-defined, yellowish to brownish, slightly elevated, twisted and bent, interrupted, cord-like plaque on his left lower abdomen. Microscopic examination revealed a sharply demarcated plate-like proliferation of pale cells localized in the papillary dermis with multiple connections to the overlying epidermis...
May 2011: Annals of Dermatology
José Carolos Cardoso, José Pedro Reis, Paulo Figueiredo, Oscar Tellechea
Tumor of the follicular infundibulum was first described in 1961 by Mehregan and Butler in a patient presenting with multiple papules. It is more frequent, however, as an isolated lesion affecting mainly the face, neck, and upper trunk. Clinical presentation is variable, requiring histology for the diagnosis, which reveals typically a plate-like proliferation of keratinocytes in continuity with the epidermis and hair follicles; some morphological features are reminiscent of the outer root sheath of the hair follicle...
2010: Dermatology Online Journal
Jane Manonukul, Piyarat Omeapinyan, Akkrarash Vongjirad
Nevus sebaceous of Jadassohn (SNJ) is a congenital, hamartoma of multiple skin structures and may classically evolve through several stages of maturation. Many neoplasms have been reported to arise in association with SNJ, most commonly trichoblastoma and syringocystadenoma papilliferum. The coexistence of 3 or more tumors arising simultaneously within 1 lesion of SNJ is very rare. We report a case of a 66-year-old woman with a coexistence of trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum, syringocystadenoma papilliferum, and mucoepidermoid or adenosquamous carcinoma arising in 2 separate and persistent SNJ exhibiting on her face with subsequent parotid node metastasis...
October 2009: American Journal of Dermatopathology
Wolfgang Weyers, Stefan Hörster, Carlos Diaz-Cascajo
Tumor of follicular infundibulum (TFI) is currently thought to be a benign epithelial neoplasm with follicular differentiation. It is encountered commonly in association with basal cell carcinoma (BCC), often as an incidental finding. We reexamined 24 cases of TFI and noted, often only focally, many changes typical of BCC, including palisading of cells at the periphery of aggregations, germinative cells, follicular germs in the absence of a follicular papilla, crowding of cells, individual necrotic neoplastic cells, fibromucinous stroma, and clefts between aggregations of neoplastic cells and stroma...
October 2009: American Journal of Dermatopathology
Ossama Abbas, Meera Mahalingam
Our recent experience indicates that the desmoplastic variant of tumor of the follicular infundibulum (TFI) is not, as previously believed, entirely uncommon. To clarify the defining clinical and microscopic features of TFI with special relevance to the histologic variants, we retrospectively reviewed cases with a histologic diagnosis of TFI between 1999 and 2008. Of the 74 cases retrieved, 53 TFI cases in 50 patients were identified with an incidence approximating 17 per 100,000. Clinically, TFI seems to be slightly more common in men (52% vs...
October 2009: American Journal of Dermatopathology
Alesso Cervantes Sartorelli, Francisco Eduardo M Leite, Isabel Violeta de Carvalho Friedman, Horácio Friedman
Tumor of the follicular infundibulum is an uncommon cutaneous lesion with different forms of clinical presentation, namely solitary and multiple/eruptive variants. The former shows predilection for head and neck and presents as a papulonodular scaly tumor. The latter is less frequent and occurs on facial, neck and upper chest areas as brown, reddish or more commonly hypopigmented macules leading to the differential diagnosis with vitiligo. The different clinical forms share the same histopathologic aspect. The present report describes a case of the multiple variant of tumor of the follicular infundibulum disclosing facial vitiligoid macules in a 35-year-old male patient...
January 2009: Anais Brasileiros de Dermatologia
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