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Inflammatory breast cancer

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https://www.readbyqxmd.com/read/29345293/s100b-expression-in-breast-cancer-as-a-predictive-marker-for-cancer-metastasis
#1
Meng-Chi Yen, Yung-Chi Huang, Jung-Yu Kan, Po-Lin Kuo, Ming-Feng Hou, Ya-Ling Hsu
In the tumor microenvironment, soluble molecules play important role in the establishment of a pre-metastatic niche. The S100 calcium-binding protein family are inflammatory molecules that contribute to the development of a pro-inflammatory tumor microenvironment. S100B belongs to the S100 family and serum S100B (also known as S100beta) serves as a marker for metastasis in lung cancer, ovarian cancer and melanoma. However, the association between S100B and the metastasis of breast cancer is not yet well understood...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29345201/clinical-validation-of-nuclear-factor-kappa-b-expression-in-invasive-breast-cancer
#2
Anil Kumar Agrawal, Ewa Pielka, Artur Lipinski, Michal Jelen, Wojciech Kielan, Siddarth Agrawal
Breast cancer is the most commonly diagnosed cancer in Polish women. The expression of transcription nuclear factor kappa B, a key inducer of inflammatory response promoting carcinogenesis and cancer progression in breast cancer, is not well-established. We assessed the nuclear factor kappa B expression in a total of 119 invasive breast carcinomas and 25 healthy control samples and correlated this expression pattern with several clinical and pathologic parameters including histologic type and grade, tumor size, lymph node status, estrogen receptor status, and progesterone receptor status...
January 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29344209/the-effect-of-royal-jelly-on-the-growth-of-breast-cancer-in-mice
#3
Shuang Zhang, Qiqi Shao, Haiyang Geng, Songkun Su
Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343723/pharmacological-targeting-of-bet-proteins-attenuates-radiation-induced-lung-fibrosis
#4
Jian Wang, Fangzheng Zhou, Zhenyu Li, Hong Mei, Ye Wang, Hong Ma, Liangliang Shi, Ai Huang, Tao Zhang, Zhenyu Lin, Gang Wu
Radiation-induced lung injury has restricted radiotherapy for thoracic cancer. The purpose of this study was to investigate the radioprotective effects of bromodomain and extra terminal (BET) inhibitor JQ1 in a murine model of pulmonary damage. Chest computed tomography (CT) was performed in a rat model after 20 Gy radiation of the right thorax. And histological evaluation and protein expressions of irradiated tissue were analyzed to confirm the potential anti-fibrosis effect of JQ1 and its underlying mechanisms...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29341321/interleukin-6-contributes-to-chemoresistance-in-mda-mb-231-cells-via-targeting-hif-1%C3%AE
#5
Ke Wang, Xue Zhu, Kai Zhang, Yongxiang Yin, Yu Chen, Ting Zhang
Chemoresistance is a critical challenge in the clinical treatment of triple-negative breast cancer (TNBC). It has been well documented that inflammatory mediators from tumor microenvironment are involved in the pathogenesis of TNBC and might be related to chemoresistance of cancer cells. In this study, the contribution of interleukin-6 (IL-6), one of the principal oncogenic molecules, in chemoresistance of a TNBC cell line MDA-MB-231 was first investigated. The results showed that IL-6 treatment could induce upregulation of HIF-1α via the activation of STAT3 in MDA-MB-231 cells, which consequently contributed to its effect against chemotherapeutic drug-induced cytotoxicity and cell apoptosis...
January 17, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29337566/cationic-polymeric-nanoparticle-delivering-ccr2-sirna-to-inflammatory-monocytes-for-tumor-microenvironment-modification-and-cancer-therapy
#6
Song Shen, Yue Zhang, Kai-Ge Chen, Ying-Li Luo, Jun Wang
Accumulating evidence has confirmed that malignant tumors have a complex microenvironment, which consists of a heterogeneous collection of tumor cells and other cell subsets (including the full gamut of immune cells). Tumor-associated macrophages (TAMs), derived from circulating Ly6Chi monocytes, constitute the most substantial fraction of tumor-infiltrating immune cells in nearly all cancer types and contribute to tumor progression, vascularization, metastasis, immunosuppression and therapeutic resistance...
January 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29334915/monitoring-the-responsiveness-of-t-and-antigen-presenting-cell-compartments-in-breast-cancer-patients-is-useful-to-predict-clinical-tumor-response-to-neoadjuvant-chemotherapy
#7
David A Bernal-Estévez, Oscar García, Ramiro Sánchez, Carlos A Parra-López
BACKGROUND: Vaccination of mice with tumors treated with Doxorubicin promotes a T cell immunity that relies on dendritic cell (DC) activation and is responsible for tumor control in vaccinated animals. Despite Doxorubicin in combination with Cyclophosphamide (A/C) is widely used to treat breast cancer patients, the stimulating effect of A/C on T and APC compartments and its correlation with patient's clinical response remains to be proved. METHODS: In this prospective study, we designed an in vitro system to monitor various immunological readouts in PBMCs obtained from a total of 17 breast cancer patients before, and after neoadjuvant anti-tumor therapy with A/C...
January 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29331323/regulation-of-inflammatory-factors-by-double-stranded-rna-receptors-in-breast-cancer-cells
#8
Amritha Venkatesh, Harika Nandigam, Maria Muccioli, Manindra Singh, Tiffany Loftus, Deana Lewis, Michelle Pate, Fabian Benencia
Malignant cells are not the only components of a tumor mass since other cells (e.g., fibroblasts, infiltrating leukocytes and endothelial cells) are also part of it. In combination with the extracellular matrix, all these cells constitute the tumor microenvironment. In the last decade the role of the tumor microenvironment in cancer progression has gained increased attention and prompted efforts directed to abrogate its deleterious effects on anti-cancer therapies. The immune system can detect and attack tumor cells, and tumor-infiltrating lymphocytes (particularly CD8 T cells) have been associated with improved survival or better response to therapies in colorectal, melanoma, breast, prostate and ovarian cancer patients among others...
November 22, 2017: Immunobiology
https://www.readbyqxmd.com/read/29330447/human-placental-derived-adherent-stromal-cells-co-induced-with-tnf-%C3%AE-and-ifn-%C3%AE-inhibit-triple-negative-breast-cancer-in-nude-mouse-xenograft-models
#9
Hoshea Allen, Niva Shraga-Heled, Michal Blumenfeld, Tamar Dego-Ashto, Dana Fuchs-Telem, Ariel Gilert, Zami Aberman, Racheli Ofir
Culturing 3D-expanded human placental-derived adherent stromal cells (ASCs) in the presence of tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) transiently upregulated the secretion of numerous anti-proliferative, anti-angiogenic and pro-inflammatory cytokines. In a 3D-spheroid screening assay, conditioned medium from these induced-ASCs inhibited proliferation of cancer cell lines, including triple-negative breast cancer (TNBC) lines. In vitro co-culture studies of induced-ASCs with MDA-MB-231 human breast carcinoma cells, a model representing TNBC, supports a mechanism involving immunomodulation and angiogenesis inhibition...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325937/histopathological-analysis-of-tamoxifen-on-epidural-fibrosis
#10
Yasar Ozturk, Ismail Bozkurt, Mesut Emre Yaman, Yahya Guvenc, Tolga Tolunay, Deniz Billur, Fatma Kubra Erbay, Salim Senturk, Gokhan Bozkurt
BACKGROUND: Epidural fibrosis is a challenging topic in spinal surgery. This phenomenon constitutes one of the the main reasons behind "post-laminectomy syndrome" or "failed-back surgery syndrome", which leads to persistent back and leg pain in association with compression and/or stretching the nerve root or the dura. The exact mechanism of action in epidural fibrosis is complex and remains uncertain. Excessive deposition of collagen, fibronectin, and dermatan sulfate known as "extracellular matrix", and decrease of tissue cellularity results in epidural fibrosis...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29321183/ptgs2-polymorphism-rs689466-favors-breast-cancer-recurrence-in-obese-patients
#11
Daniely Regina Freitas-Alves, Hayra de Andrade Vieira-Monteiro, Diogo Nascimento Piranda, Marcelo Sobral-Leite, Taiana Sousa Lopes da Silva, Anke Bergmann, Samuel Dos Santos Valença, Jamila Alessandra Perini, Rosane Vianna-Jorge
Breast cancer is the leading cancer among women, and its increasing incidence is a challenge worldwide. Estrogen exposure is the main risk factor, but obesity among postmenopausal women has been shown to favor disease onset and progression. The link between obesity and mammary carcinogenesis involves elevated estrogen production and pro-inflammatory stimuli within the adipose tissue, with activation of the cyclooxygenase-2 pathway. Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (N = 1038)...
January 10, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29316682/effect-of-omega-3-fatty-acid-supplementation-on-oxylipins-in-a-routine-clinical-setting
#12
Christoph Schmöcker, Ingrid W Zhang, Stefanie Kiesler, Ursula Kassner, Annika I Ostermann, Elisabeth Steinhagen-Thiessen, Nils H Schebb, Karsten-H Weylandt
Omega-6 polyunsaturated fatty acid (n-6 PUFA) is the predominant polyunsaturated fatty acid (PUFA), especially in Western diet. A high omega-6/omega-3 ratio in Western diets is implicated in the development of cardiovascular diseases and inflammatory processes. Studies in animal models and in humans have demonstrated beneficial effects of omega-3 PUFA (n-3 PUFA) in a variety of diseases, including cardiac arrhythmias and inflammatory diseases, as well as breast and colon cancer. The molecular mechanisms underlying the effects of n-3 PUFA are still not well understood...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315254/prognostic-significance-of-activated-leukocyte-cell-adhesion-molecule-alcam-in-association-with-promoter-methylation-of-the-alcam-gene-in-breast-cancer
#13
Young Ju Jeong, Hoon Kyu Oh, Sung Hwan Park, Jin Gu Bong
Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis. In this study, we studied DNA methylation status of the ALCAM gene using pyrosequencing in breast cancer tissues. We analyzed the association between the methylation status of the ALCAM gene and its expression. Also, the effects of inflammation on the ALCAM gene methylation and its expression were investigated. The ALCAM gene methylation was associated with the ALCAM transcripts in tumor tissues. The methylation status of the ALCAM gene was not significantly different between tumor and normal tissues...
January 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29308928/overall-dietary-intake-and-prognosis-after-breast-cancer-a-systematic-review
#14
Caroline O Terranova, Melinda M Protani, Marina M Reeves
Breast cancer survivors often seek information about how lifestyle factors, such as diet, may influence their prognosis. Previous studies have reviewed evidence around single nutrients, individual foods or food groups. We reviewed studies examining relationships between overall dietary intake and prognosis in breast cancer survivors. A systematic search was conducted to identify studies, published until June 2016, which assessed associations between overall dietary intake (i.e., quality; score; pattern) and mortality and/or recurrence in breast cancer survivors...
January 8, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29301388/panduratin-a-inhibits-cell-proliferation-by-inducing-g0-g1-phase-cell-cycle-arrest-and-induces-apoptosis-in-breast-cancer-cells
#15
Qiuming Liu, Yali Cao, Ping Zhou, Shimin Gui, Xiaobo Wu, Yong Xia, Jianhong Tu
Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin A (PA) possesses many health benefits, including anti-inflammatory, anti-bacterial, anti-oxidant and anticancer activities. In the present study, we provide evidence that PA treatment of MCF-7 BC cells resulted in a time- and dosedependent inhibition of cell growth with an IC₅₀ of 15 μM and no to little effect on normal human MCF-10A breast cells...
January 5, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29298955/infectious-and-inflammatory-breast-disease
#16
Kathryn Faguy
Breast inflammation can signal an array of breast conditions, from difficulties with breastfeeding to a rare and aggressive type of breast cancer. In some cases, these diseases resemble each other clinically and on imaging examinations. This article explains the inflammatory process and discusses a variety of localized benign inflammatory breast diseases, including lactational and nonlactational mastitis, ductal ectasia, idiopathic granulomatous mastitis, fat necrosis, and diabetic mastopathy. Inflammatory breast cancer also is presented, with an emphasis on its signs and symptoms, diagnosis, staging, multimodality treatment, and prognosis...
January 2018: Radiologic Technology
https://www.readbyqxmd.com/read/29295697/towards-prevention-of-ovarian-cancer
#17
Aus Tariq Ali
Ovarian cancer is the leading cause of death of all gynaecological cancers. To date, there is no reliable, specific screening procedure for detecting ovarian cancer. The risk factors of ovarian cancer include modifiable and non-modifiable factors. The main goal of the ovarian cancer prevention program is to significantly reduce the risk of development of ovarian cancer and other cancers such as breast and/or peritoneal cancer. The application of non-surgical preventive approaches such as oral contraceptives, parity and breastfeeding has been shown to be highly protective against ovarian cancer development...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29290824/a-transferrin-conjugated-hollow-nanoplatform-for-redox-controlled-and-targeted-chemotherapy-of-tumor-with-reduced-inflammatory-reactions
#18
Jun Zhou, Menghuan Li, Wei Qi Lim, Zhong Luo, Soo Zeng Fiona Phua, Runlan Huo, Liqi Li, Ke Li, Liangliang Dai, Junjie Liu, Kaiyong Cai, Yanli Zhao
Purpose: In this study, we report the design, development and evaluation of a hollow drug delivery nanoplatform for cancer therapy in vitro and in vivo. This composite nanosystem was prepared by modifying hollow mesoporous silica nanoparticles (HMSNs) with transferrin (Tf) targeting moieties via redox-liable linkage, and was capable of delivering therapeutic cargos (doxorubicin) specifically to the tumor site and subsequently releasing them in an on-demand manner. Moreover, the Tf corona could simultaneously reduce the inflammatory response after intravenous administration in vivo...
2018: Theranostics
https://www.readbyqxmd.com/read/29289266/is-myc-an-important-biomarker-myc-expression-in-immune-disorders-and-cancer
#19
REVIEW
Shivtia Trop-Steinberg, Yehudit Azar
The proto-oncogene Myc serves as a paradigm for understanding the dynamics of transcriptional regulation. Myc protein has been linked to immune dysfunction, cancer development and neoplastic transformation. We review recent research regarding functions of Myc as an important modulator in immune disorders, postallogeneic hematopoietic stem cell transplantation (HSCT) and several cancers. Myc overexpression has been repeatedly linked to immune disorders and specific cancers, such as myasthenia gravis, psoriasis, pemphigus vulgaris, atherosclerosis, long-term allogeneic survival among HSCT patients, (primary) inflammatory breast cancer, (primary) ovarian carcinoma and hematological malignancies: acute myeloid leukemia, chronic myelogenous leukemia, Hodgkin's lymphoma and diffuse large B-cell lymphoma...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29287197/breast-cancer-lesser-known-facets-and-hypotheses
#20
REVIEW
Seema Patel
Breast cancer is the most common cancer in females. The deteriorating environment, and lifestyle flaws are raising the frequency of this cancer. Existing therapies are not universally-effective, and they cause side effects, relapses, and high mortality rate. Alternative medications may be milder, but are less effective or are inadequate for a complex disease like the breast cancer. So, it requires the understanding that drugs are not the solution of this cancer, but prevention is the sustainable solution. In the past decades, an enormous quantum of insights on this disease has been obtained...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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