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Inflammatory breast cancer

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https://www.readbyqxmd.com/read/27910972/a-liver-microphysiological-system-of-tumor-cell-dormancy-and-inflammatory-responsiveness-is-affected-by-scaffold-properties
#1
A M Clark, S E Wheeler, C L Young, L Stockdale, J Shepard Neiman, W Zhao, D B Stolz, R Venkataramanan, D Lauffenburger, L Griffith, A Wells
Distant metastasis is the major cause of breast cancer-related mortality, commonly emerging clinically after 5 or more years of seeming 'cure' of the primary tumor, indicating a quiescent dormancy. The lack of relevant accessible model systems for metastasis that recreate this latent stage has hindered our understanding of the molecular basis and the development of therapies against these lethal outgrowths. We previously reported on the development of an all-human 3D ex vivo hepatic microphysiological system that reproduces several features of liver physiology and enables spontaneous dormancy in a subpopulation of breast cancer cells...
December 2, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27904654/augmentation-of-histone-deacetylase-3-hdac3-epigenetic-signature-at-the-interface-of-proinflammation-and-insulin-resistance-in-patients-with-type-2-diabetes
#2
Chandrakumar Sathishkumar, Paramasivam Prabu, Mahalingam Balakumar, Raji Lenin, Durai Prabhu, Ranjith Mohan Anjana, Viswanathan Mohan, Muthuswamy Balasubramanyam
BACKGROUND: A role of proinflammation has been implicated in the pathogenesis of diabetes, but the up-stream regulatory signals and molecular signatures are poorly understood. While histone modifications such as changes in histone deacetylase (HDAC) are emerging as novel epigenetic biomarkers, there is lack of studies to demonstrate their clinical relevance in diabetes. Therefore, we investigated the extent of HDAC machinery and inflammatory signals in peripheral blood mononuclear cells (PBMCs) from patients with type 2 diabetes mellitus (T2DM) compared to control subjects...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#3
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27903155/obesity-and-cancer-mechanisms-tumor-microenvironment-and-inflammation
#4
Neil M Iyengar, Ayca Gucalp, Andrew J Dannenberg, Clifford A Hudis
Purpose There is growing evidence that inflammation is a central and reversible mechanism through which obesity promotes cancer risk and progression. Methods We review recent findings regarding obesity-associated alterations in the microenvironment and the local and systemic mechanisms through which these changes support tumor growth. Results Locally, hyperadiposity is associated with altered adipose tissue function, adipocyte death, and chronic low-grade inflammation. Most individuals who are obese harbor inflamed adipose tissue, which resembles chronically injured tissue, with immune cell infiltration and remodeling...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27893337/inflammatory-cytokines-and-comorbidity-development-in-breast-cancer-survivors-versus-noncancer-controls-evidence-for-accelerated-aging
#5
Catherine M Alfano, Juan Peng, Rebecca R Andridge, Monica E Lindgren, Stephen P Povoski, Adele M Lipari, Doreen M Agnese, William B Farrar, Lisa D Yee, William E Carson, Janice K Kiecolt-Glaser
Purpose The sequelae of cancer treatment may increase systemic inflammation and create a phenotype at increased risk of functional decline and comorbidities, leading to premature mortality. Little is known about how this trajectory compares with natural aging among peers of the same age without cancer. This longitudinal study investigated proinflammatory cytokines and comorbidity development over time among breast cancer survivors and a noncancer control group. Methods Women (N = 315; 209 with breast cancer and 106 in the control group) were recruited at the time of their work-up for breast cancer; they completed the baseline questionnaire, interview, and blood draw (lipopolysaccharide-stimulated production of interleukin [IL] -6, tumor necrosis factor-α, and IL-1β)...
November 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27891654/the-relationship-between-oestrogen-receptor-alpha-phosphorylation-and-the-tumour-microenvironment-in-patients-with-primary-operable-ductal-breast-cancer
#6
Kelvin K W Cheng, Ashley Dickson, Fadia J A Gujam, Donald C McMillan, Joanne Edwards
AIMS: Although the role of phosphorylation of oestrogen receptor (ER) at serines 118 (p-S118) and 167 (p-S167) have been studied, the relationship between p-S118, p-S167 and the tumour microenvironment in ER-positive primary operable ductal breast cancers have not been investigated. The aims of this study are to investigate (1) the relationship between p-S118/p-S167 and the tumour microenvironment and (2) the effect of p-S118/167 on survival and recurrence in ER-positive primary operable ductal breast cancers...
November 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27890459/relationship-of-systemic-cytokine-concentrations-to-cognitive-function-over-two-years-in-women-with-early-stage-breast-cancer
#7
Debra E Lyon, Ronald Cohen, Huaihou Chen, Debra L Kelly, Nancy L McCain, Angela Starkweather, Hyochol Ahn, Jamie Sturgill, Colleen K Jackson-Cook
: Cancer and its treatment are frequently associated with cancer-related cognitive impairment (CRCI). While CRCI has been associated with linked to chemotherapy, there is increasing evidence that the condition may start prior to treatment and for some, remain unresolved after active treatment and into survivorship. Although the pathophysiology of the condition is complex, alterations in systemic cytokines, signaling molecules activated in response to infection or injury that trigger inflammation, are a possible mechanism linked to cognitive dysfunction in breast cancer and other conditions...
November 13, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27889687/role-of-inflammation-in-obesity-related-breast-cancer
#8
REVIEW
Elisa Crespi, Giulia Bottai, Libero Santarpia
Chronic inflammation associated with obesity is now recognized to be an important condition in promoting carcinogenesis and progression in breast cancer patients, mostly in postmenopausal women with tumors expressing estrogen and progesterone receptors. In obese patients, altered levels of several inflammatory mediators regulating aromatase and estrogen expression are one of the mechanisms responsible of increase breast cancer risk. Growing attention has also been paid to the local adipose inflammation and the role played by macrophages as determinants of breast cancer risk recurrence and prognosis...
November 24, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27888633/toll-like-receptor-9-expression-is-associated-with-breast-cancer-sensitivity-to-the-growth-inhibitory-effects-of-bisphosphonates-in-vitro-and-in-vivo
#9
Jouko Sandholm, Jaakko Lehtimäki, Tamiko Ishizu, Sadanandan E Velu, Jeremy Clark, Pirkko Härkönen, Arja Jukkola-Vuorinen, Aleksi Schrey, Kevin W Harris, Johanna M Tuomela, Katri S Selander
Bisphosphonates are standard treatments for bone metastases. When given in the adjuvant setting, they reduce breast cancer mortality and recurrence in bone but only among post-menopausal patients. Optimal drug use would require biomarker-based patient selection. Such biomarkers are not yet in clinical use. Based on the similarities in inflammatory responses to bisphosphonates and Toll-like receptor (TLR) agonists, we hypothesized that TLR9 expression may affect bisphosphonate responses in cells. We compared bisphosphonate effects in breast cancer cell lines with low or high TLR9 expression...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887569/immune-modulation-of-cd4-cd25-regulatory-t-cells-by-zoledronic-acid
#10
Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Jo-Lin Lo, Tsun-Mei Lin
BACKGROUND: CD4(+)CD25(+) regulatory T (Treg) cells suppress tumor immunity by inhibiting immune cells. Manipulation of Treg cells represents a new strategy for cancer treatment. Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, inhibits the expression of receptor activator of nuclear factor kappa-B ligand (RANKL) on osteoblasts to inhibit osteoclastogenesis. In a mouse model of bisphosphonate-related osteonecrosis of the jaw, administration of ZA suppressed Treg-cell activity and activated inflammatory Th17 cells...
November 25, 2016: BMC Immunology
https://www.readbyqxmd.com/read/27881676/cytoplasmic-localization-of-proline-glutamic-acid-leucine-rich-protein-1-pelp1-induces-breast-epithelial-cell-migration-through-upregulation-of-inhibitor-of-kappa-b-kinase-epsilon-and-inflammatory-crosstalk-with-macrophages
#11
Brian J Girard, Todd P Knutson, Bethanie Kuker, Laura McDowell, Kathryn L Schwertfeger, Julie H Ostrander
Cytoplasmic localization of proline, glutamic acid, leucine rich protein 1 (PELP1) is observed in about 40% of women with invasive breast cancer. In mouse models, PELP1 overexpression in the mammary gland leads to pre-malignant lesions and eventually mammary tumors. In preliminary clinical studies, cytoplasmic localization of PELP1 was seen in 36% of women at high risk of developing breast cancer. Here, we investigated whether cytoplasmic PELP1 signaling promotes breast cancer initiation in models of immortalized human mammary epithelial cells (HMECs)...
November 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27880817/melissa-officinalis-protects-against-doxorubicin-induced-cardiotoxicity-in-rats-and-potentiates-its-anticancer-activity-on-mcf-7-cells
#12
Alaaeldin Ahmed Hamza, Mahguob Mohamed Ahmed, Hanan Mohamed Elwey, Amr Amin
Cardiotoxicity is a limiting factor of doxorubicin (DOX)-based anticancer therapy. Due to its beneficial effects, we investigated whether standardized extract of Melissa officinalis (MO) can attenuate doxorubicin-induced cardiotoxicity and can potentiate the efficacy of DOX against human breast cancer cells. MO was administered orally to male albino rats once daily for 10 consecutive days at doses of 250, 500 and 750 mg/kg b.wt. DOX (15 mg/kg b.wt. i.p.) was administered on the 8th day. MO protected against DOX-induced leakage of cardiac enzymes and histopathological changes...
2016: PloS One
https://www.readbyqxmd.com/read/27879265/il-6-signaling-in-peripheral-blood-t-cells-predicts-clinical-outcome-in-breast-cancer
#13
Lei Wang, Andrea K Miyahira, Diana Simons, Xuyang Lu, Andrew Chang, Carrie Wang, Maria Suni, Vernon C Maino, Frederick M Dirbas, John H Yim, James Waisman, Peter P Lee
Interleukin-6 (IL-6) is a pleiotropic cytokine with both pro- and anti-inflammatory properties which acts directly on cancer cells to promote their survival and proliferation. Elevated serum IL-6 levels negatively correlate with survival of cancer patients, which is generally attributed to the direct effects of IL-6 on cancer cells. How IL-6 modulates the host immune response in cancer patients is unclear. Here we show the IL-6 signaling response in peripheral blood T cells is impaired in breast cancer (BC) patients and is associated with blunted Th17 differentiation...
November 22, 2016: Cancer Research
https://www.readbyqxmd.com/read/27877223/prognostic-impact-of-hormone-receptor-and-her2-defined-subtypes-in-inflammatory-breast-cancer-treated-with-high-dose-chemotherapy-a-retrospective-study
#14
Laurys Boudin, Anthony Gonçalves, Patrick Sfumato, Renaud Sabatier, François Bertucci, Carole Tarpin, Magali Provansal, Gilles Houvenaeghel, Eric Lambaudie, Agnes Tallet, Michel Resbeut, Emmanuelle Charafe-Jauffret, Boris Calmels, Claude Lemarie, Jean-Marie Boher, Jean-Marc Extra, Patrice Viens, Christian Chabannon
Purpose: Studies examining high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HDC-AHSCT) strategies in inflammatory breast cancer (IBC), showed encouraging results in terms of disease-free survival (DFS), and overall survival (OS). The lack of data regarding HER2 status in all of these studies prevented any prognostic analysis involving breast cancer subtypes. Methods: All consecutive female patients treated for IBC with HDC and AHSCT at Institut Paoli-Calmettes between 2003 and 2012 were included...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27875786/inflammation-dysregulated-metabolism-and-aromatase-in-obesity-and-breast-cancer
#15
REVIEW
Heba Zahid, Evan R Simpson, Kristy A Brown
Obesity is associated with an increased risk of estrogen-dependent breast cancer after menopause. Adipose tissue undergoes important changes in obesity due to excess storage of lipids, leading to adipocyte cell death and the recruitment of macrophages. The resultant state of chronic low-grade inflammation is associated with the activation of NFkB signaling and elevated levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis. This occurs not only in the visceral and subcutaneous fat, but also in the breast fat...
November 19, 2016: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/27872096/polyi-c-and-cpg-synergize-with-anti-erbb2-mab-for-treatment-of-breast-tumors-resistant-to-immune-checkpoint-inhibitors
#16
Roxanne Charlebois, Bertrand Allard, David Allard, Laurence Buisseret, Martin Turcotte, Sandra Pommey, Pavel Chrobak, John Stagg
Innate and adaptive immune cells play an important role in the therapeutic activity of anti-ErbB2 mAbs such as trastuzumab. In the clinic, breast tumors poorly infiltrated with immune cells are more resistant to trastuzumab and patients have a worse prognosis. Because type I and II interferons (IFNs) are critical to the immune-mediated activity of anti-ErbB2 mAb, we investigated the effect of combining polyI:C and CpG with trastuzumab-like therapy in immunocompetent mouse models of ErbB2+ breast cancer. We demonstrated that in situ delivery of polyI:C and CpG combined to systemic anti-ErbB2 mAb triggered a potent inflammatory response in breast tumors able to induce long lasting CD8+ T cell-dependent anti-tumor immunity...
November 21, 2016: Cancer Research
https://www.readbyqxmd.com/read/27869438/immunology-update-biologics
#17
S Paul Starr
Biologics are substances made from a living organism or its products. These include genes, proteins (eg, antibodies, receptors, enzymes, inhibitors), recombinant proteins, and fusion proteins. Biologics often are produced using recombinant DNA technology. For example, monoclonal antibodies are produced by inserting human genes into immortalized cell cultures, which then produce the gene product (ie, an antibody) in large quantity. Another approach is to fuse genetic material from nonhuman sources (eg, mice) with human genetic material...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27865894/activation-of-peroxisome-proliferator-activated-receptor-gamma-in-mammary-epithelial-cells-upregulates-the-expression-of-tumor-suppressor-cyld-to-mediate-growth-inhibition-and-anti-inflammatory-effects
#18
Athanasios Pseftogas, Christos Gonidas, George Mosialos
Several studies have implicated the downregulation of the tumor suppressor Cyld expression in breast cancer development. However, the mechanisms that regulate Cyld expression in mammary epithelial cells are largely unknown. In order to investigate them, a bioinformatic analysis of the promoter region of Cyld was performed and identified putative nuclear hormone receptor response elements that included peroxisome proliferator-activated receptor gamma (PPAR-γ)-responsive elements. In the present study, we showed that upon activation of the nuclear hormone receptor PPAR-γ by the agonist troglitazone (TZD), there was a significant increase in Cyld mRNA in human mammary epithelial cell lines...
November 16, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27863332/combined-effect-of-aerobic-interval-training-and-selenium-nanoparticles-on-expression-of-il-15-and-il-10-tnf-%C3%AE-ratio-in-skeletal-muscle-of-4t1-breast-cancer-mice-with-cachexia
#19
M Molanouri Shamsi, S Chekachak, S Soudi, L S Quinn, K Rangbar, J Chenari, M H Yazdi, M Mahdavi
Cancer cachexia is characterized by inflammation, loss of skeletal muscle and adipose tissue mass, and functional impairment. Oxidative stress and inflammation are believed to regulate pathways controlling skeletal muscle wasting. The aim of this study was to determine the effects of aerobic interval training and the purported antioxidant treatment, selenium nanoparticle supplementation, on expression of IL-15 and inflammatory cytokines in 4T1 breast cancer-bearing mice with cachexia. Selenium nanoparticle supplementation accelerated cachexia symptoms in tumor-bearing mice, while exercise training prevented muscle wasting in tumor-bearing mice...
November 15, 2016: Cytokine
https://www.readbyqxmd.com/read/27860246/prospective-study-of-the-dietary-inflammatory-index-and-risk-of-breast-cancer-in-postmenopausal-women
#20
Nitin Shivappa, Cindy K Blair, Anna E Prizment, David R Jacobs, James R Hébert
SCOPE: Diet in relation to breast cancer etiology has been studied widely, but results have remained inconsistent. Various dietary components including fruits, vegetables, and meat have been implicated through their effects on inflammation. Using data from the Iowa Women's Health Study we examine prospectively the association between the dietary inflammatory index (DII) and breast cancer incidence. METHODS AND RESULTS: DII scores were computed based on baseline dietary intake assessed by a validated 121-item food frequency questionnaire in a cohort of 34,700 women, aged 55-69 years at recruitment in 1986 and followed for incident breast cancer...
November 10, 2016: Molecular Nutrition & Food Research
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