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https://www.readbyqxmd.com/read/29735320/intravitreal-aflibercept-therapy-in-eyes-with-chronic-central-serous-chorioretihopathy-short-term-results
#1
K Tekin, P Cakar Ozdal, B Gulpamuk, M Yasin Teke
OBJECTIVES: To evaluate the short term efficacy and tolerability results of intravitreal aflibercept injection as a treatment option for eyes with chronic central serous chorioretinopathy (CSCR). MATERIAL AND METHODS: A prospective longitudinal study. Ten eyes of 10 patients with chronic CSCR who had been followed for >6months after the first intravitreal injection of aflibercept were recruited for the study. The best corrected visual acuity (BCVA) and central macular thickness (CMT) values obtained by spectral-domain optical coherence tomography were recorded at baseline and the first, third, and sixth months after the injection...
May 4, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29656602/evolution-of-fundus-autofluorescence-patterns-over-time-in-patients-with-chronic-central-serous-chorioretinopathy
#2
Marta Zola, Irini Chatziralli, Deepthy Menon, Roy Schwartz, Phil Hykin, Sobha Sivaprasad
PURPOSE: To determine the evolution of fundus autofluorescence (FAF) patterns in chronic central serous chorioretinopathy (CSCR) over time. METHODS: We retrospectively studied the changes in FAF patterns over time in 157 eyes of 112 patients with chronic CSCR using the Heidelberg Retina Angiography with a 488-nm excitation light and a 500-nm cutoff barrier filter. RESULTS: The mean duration of follow-up was 37.2 months. The most common baseline pattern was that of granular hypoautofluorescence (51...
April 15, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29643793/central-serous-chorioretinopathy-associated-with-desmopressin-nasal-spray-causality-or-unfortunate-association
#3
Nacima Kisma, Eleni Loukianou, Bishwanath Pal
Purpose: To describe the possible association between central serous chorioretinopathy (CSCR) and desmopressin use. Methods: The case histories of 2 middle-aged men with CSCR using desmopressin nasal spray were studied. Results: The diagnosis of CSCR was made on the basis of clinical features and ancillary testing (fluorescein angiography and optical coherence tomography). Both patients were using desmopressin nasal spray for polyuria when they developed the first ocular symptoms...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29582814/change-in-choroidal-vascularity-in-acute-central-serous-chorioretinopathy
#4
Mohammed Abdul Rasheed, Abhilash Goud, Ashik Mohamed, Kiran Kumar Vupparaboina, Jay Chhablani
Purpose: This study aims to compare the effect of laser photocoagulation or observation on choroidal vascularity in acute central serous chorioretinopathy (CSCR). Methods: A retrospective analysis of 30 patients with acute CSCR treated either with laser photocoagulation (16 eyes) or sham laser (14 eyes) was performed. Demographic details, visual acuity (VA) assessment, and other relevant clinical data were considered from baseline to the 3rd and 6th month follow-up visits...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29487828/long-term-outcomes-for-patients-treated-with-half-fluence-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy-a-case-series
#5
Jennifer Doyle, Bhaskar Gupta, Irfan Tahir
A case series was used to evaluate the efficacy of half-fluence photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR). Patients were treated with standard-dose verteporfin and half-fluence PDT. Totally 13 eyes from 11 patients were included. The mean patient age was 52.0y. There was a mean reduction in central retinal thickness of 107.0 microns. Totally 7/13 eyes (53.8%) achieved resolution of subretinal fluid (SRF) on optical coherence tomography (OCT) scan after 1 treatment with PDT...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29474303/association-of-obstructive-sleep-apnea-with-central-serous-chorioretinopathy-and-choroidal-thickness-a-systematic-review-and-meta-analysis
#6
Chris Y Wu, Tanawan Riangwiwat, Pattara Rattanawong, Brooke L W Nesmith, Avnish Deobhakta
PURPOSE: Obstructive sleep apnea (OSA) has been associated with an array of ocular disorders. This systematic review aims to investigate the association of OSA with central serous chorioretinopathy (CSCR) and subfoveal choroidal thickness changes on enhanced depth imaging optical coherence tomography. METHODS: Systematic review and meta-analysis of all articles published up to November 2017 examining rate of OSA in patients with CSCR versus controls or examining subfoveal choroidal thickness measurements on enhanced depth imaging optical coherence tomography in patients with OSA versus controls...
February 22, 2018: Retina
https://www.readbyqxmd.com/read/29429986/comparison-of-photodynamic-therapy-and-navigated-microsecond-laser-for-chronic-central-serous-chorioretinopathy
#7
Cyprian Gabriel Ntomoka, Bindu Rajesh, Gachago Muchai Muriithi, Abhilash Goud, Jay Chhablani
OBJECTIVES: To compare the visual and anatomical outcomes after photodynamic therapy (PDT) and navigated microsecond laser (nMSL) for chronic central serous chorioretinopathy (CSCR). METHODS: This retrospective study included eyes with chronic CSCR who underwent either PDT or nMSL with a minimum of 6 months' follow-up. Eyes with a history of treatment with any other modalities in the past or during 6 months post PDT or microsecond laser follow-up were excluded. Primary outcome measures included change in best-corrected visual acuity (BCVA) and central macular thickness (CMT)...
February 12, 2018: Eye
https://www.readbyqxmd.com/read/29359109/proteome-and-metabolome-of-subretinal-fluid-in-central-serous-chorioretinopathy-and-rhegmatogenous-retinal-detachment-a-pilot-case-study
#8
Laura Kowalczuk, Alexandre Matet, Marianne Dor, Nasim Bararpour, Alejandra Daruich, Ali Dirani, Francine Behar-Cohen, Aurélien Thomas, Natacha Turck
Purpose: To investigate the molecular composition of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR) and rhegmatogenous retinal detachment (RRD) using proteomics and metabolomics. Methods: SRF was obtained from one patient with severe nonresolving bullous CSCR requiring surgical subretinal fibrin removal, and two patients with long-standing RRD. Proteins were trypsin-digested, labeled with Tandem-Mass-Tag and fractionated according to their isoelectric point for identification and quantification by tandem mass spectrometry...
January 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29207100/retinal-microvasculature-alteration-in-central-serous-chorioretinopathy
#9
Li Yu, Yi Shao, Yong Chai, Lin-Hong Ye, Qi-Chen Yang, Lei Ye, Qing Yuan, Nan Jiang, Jing-Lin Yi
The aim of the present study was to investigate the changes of retinal microvascular network in patients with central serous chorioretinopathy (CSCR). A total of fifteen patients (right eye) with CSCR and 15 normal controls (right eye) were recruited. We used optical coherence tomography angiography to scan 6x6 mm macular retinal blood flow images with the application of a series of customized image segmentation processing program software to obtain microvascular and macrovascular density, and compared the superficial microvascular (SMIR), superficial macrovascular ring (SMAR) and the superficial total microvascular (STMI) density between CSCR patients and control group...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29166869/multimodal-imaging-of-retinal-pigment-epithelial-detachments-in-patients-with-c3-glomerulopathy-case-report-and-review-of-the-literature
#10
REVIEW
Valeria Kheir, Ali Dirani, Matthieu Halfon, Jean-Pierre Venetz, Georges Halabi, Yan Guex-Crosier
BACKGROUND: To describe the optical coherence tomography angiograhy (OCTA) of drusenoid pigment epithelial detachments (PEDs) in a woman affected by Complement 3 (C3) glomerulopathy, which represents a spectrum of glomerular diseases characterized on fluorescent microscopy by C3 accumulation with absent, or scanty, immunoglobulin deposits. It is due to acquired or genetically defective alternative pathway control and is generally associated with drusen-like deposits in Bruch's membrane, as well as choriocapillaris...
November 22, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29109866/correlation-between-choroidal-neovascularization-shown-by-oct-angiography-and-choroidal-thickness-in-patients-with-chronic-central-serous-chorioretinopathy
#11
Joanna Gołębiewska, Joanna Brydak-Godowska, Joanna Moneta-Wielgoś, Monika Turczyńska, Dariusz Kęcik, Wojciech Hautz
Purpose: To assess the occurrence of choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR) using optical coherence tomography angiography (OCTA) and correlate these findings with choroidal thickness (CT). Materials and Methods: This retrospective study included 25 consecutive patients (43 eyes), mean age 48.12 ± 7.8 years, diagnosed with persistent CSCR. All patients underwent a complete ophthalmic examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography, and OCTA...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29098100/chronic-central-serous-chorioretinopathy-in-a-patient-with-pigment-dispersion-syndrome-a-possible-correlation
#12
Dimitrios Kourkoutas, George Tsakonas, Aristotelis Karamaounas, Nikolaos Karamaounas
Chronic central serous chorioretinopathy (CSCR) is a progressive chorioretinopathy with widespread atrophic RPE abnormalities and serous retinal detachments (SRDs) present for 6 months or longer. We report a case of CSCR in a 38-year-old patient with Pigment Dispersion Syndrome (PDS). In the presented case of CSCR, the chronic course of the disease may in part be associated with an underlying generalized degenerative dysfunction of the pigmented cells of the eye on grounds of PDS. We suggest that a chronic course of disease may be suspected in the setting of CSCR with concurrent RPE pathology, such as what is found in PDS...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29020431/overloaded-dysfunctional-rpe-leads-to-delayed-absorption-of-subretinal-fluid-after-retinal-detachment-repair
#13
Patrick Oellers, Dean Eliott
Persistent subretinal fluid (SRF) can impair visual recovery after vitrectomy or scleral buckling surgery for rhegmatogenous retinal detachment. Several hypotheses have been proposed for delayed absorption of SRF, but the etiology has not been clearly identified. The authors present a patient with persistent SRF after vitrectomy for retinal detachment who developed central serous chorioretinopathy (CSCR) during the postoperative period in the nonoperative eye. Thus, subclinical retinal pigment epithelial (RPE) dysfunction was likely present in the operative eye, and when overloaded with SRF after retinal detachment repair, this manifested as delayed absorption...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28947395/tolerance-of-high-and-low-amounts-of-plga-microspheres-loaded-with-mineralocorticoid-receptor-antagonist-in-retinal-target-site
#14
Min Zhao, Esther Rodríguez-Villagra, Laura Kowalczuk, Manon Le Normand, Marianne Berdugo, Rinath Levy-Boukris, Ikram El Zaoui, Béatrice Kaufmann, Robert Gurny, Irene Bravo-Osuna, Irene T Molina-Martínez, Rocío Herrero-Vanrell, Francine Behar-Cohen
Mineralocorticoid receptor (MR) contributes to retinal/choroidal homeostasis. Excess MR activation has been shown to be involved in pathogenesis of central serous chorioretinopathy (CSCR). Systemic administration of MR antagonist (MRA) reduces subretinal fluid and choroidal vasodilation, and improves the visual acuity in CSCR patients. To achieve long term beneficial effects in the eye while avoiding systemic side-effects, we propose the use of biodegradable spironolactone-loaded poly-lactic-co-glycolic acid (PLGA) microspheres (MSs)...
November 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28892948/microperimetry-a-new-tool-for-assessing-retinal-sensitivity-in-macular-diseases
#15
Memota Laishram, Krishnagopal Srikanth, A R Rajalakshmi, Swathi Nagarajan, G Ezhumalai
INTRODUCTION: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. AIM: To study the retinal sensitivity changes in macular diseases using microperimetry. MATERIALS AND METHODS: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28868032/spironolactone-for-secondary-central-serous-chorioretinopathy-a-challenge-rechallenge-case
#16
Kapil G Kapoor, Jennifer Sim
Central serous chorioretinopathy (CSCR) is potentially sight-threatening and has been associated with corticosteroid use. CSCR secondary to steroid use can sometimes be challenging to treat, especially if continuing steroid use is medically necessary. In this case report we demonstrate the efficacy of spironolactone as an effective agent in countering CSCR secondary to steroid use. This challenge-rechallenge case may be helpful to clinicians in delineating a treatment paradigm for these patients.
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28845331/atypical-central-serous-chorioretinopathy
#17
Zafer Cebeci, Merih Oray, Şerife Bayraktar, İlknur Tuğal-Tutkun, Nur Kır
Bullous central serous chorioretinopathy (CSCR) is a rare variant of CSCR characterized by severe serous retinal detachment which especially involves the inferior quadrants. Corticosteroid therapy administered for systemic or ocular misdiagnoses may induce and exacerbate CSCR. The purpose of this study was to report diagnosis and treatment results of an unusual case of bullous CSCR induced by systemic and periocular corticosteroid therapy received at another medical center due to a misdiagnosis of Vogt-Koyanagi-Harada disease...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28814876/neutrophil-lymphocyte-ratio-and-mean-platelet-volume-in-central-serous-chorioretinopathy
#18
Muhammet Kazim Erol, Ayse Balkarli, Ozgur Yucel, Yusuf Akar, Berna Dogan, Elcin Suren
PURPOSE: This study aimed to evaluate mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) values and their relationship with clinical findings in patients with central serous chorioretinopathy (CSCR). METHODS: Overall, 87 patients fulfilling inclusion criteria and 320 age- and sex-matched healthy individuals as controls were included in the study. The CSCR patients (n=87) were classified into 2 groups as acute CSCR (group 1, n=43) and chronic CSCR (group 2, n=44)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28798899/diagnosed-a-patient-with-central-serous-chorioretinopathy-now-what-management-of-central-serous-chorioretinopathy
#19
Brian E Goldhagen, Raquel Goldhardt
PURPOSE OF REVIEW WHAT IS THE GOAL OF YOUR PAPER? WHAT QUESTIONS DID YOU SEEK TO ANSWER?: The goal of this paper is to provide a comprehensive review of the management options for central serous chorioretinopathy (CSCR). RECENT FINDINGS SUMMARIZE THE LATEST RESEARCH ON YOUR TOPIC: The majority of cases of acute CSCR may be managed with observation and cessation of corticosteroids, if possible, as well as life-style modifications including stress reduction and control of hypertension...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28797227/changes-in-macular-sensitivity-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#20
Alp Atik, Yijun Hu, Honghua Yu, Chun Yang, Bin Cai, Yijing Tao, Dongli Li, Yan Chen, Li Lu, Guodong Li, Ling Yuan
BACKGROUND: To evaluate the macular sensitivity changes after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR). METHODS: Eighteen patients (26 eyes) with chronic CSCR were recruited in the same hospital between April 2011 and December 2012. All patients were treated with one session of half-dose PDT after complete ophthalmic examination. Macular sensitivity examination was performed at baseline and 1, 3 and 6 months post-treatment...
August 10, 2017: BMC Ophthalmology
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