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Hasan Altinkaynak, Piraye Zeynep Kurkcuoglu, Mehtap Caglayan, Mücella Arıkan Yorgun, Nilay Yuksel, Pınar Kosekahya, Cemile Koca, Yasin Toklu
PURPOSE: The aim of this study was to compare dynamic thiol/disulfide homeostatic status in acute central serous chorioretinopathy (CSCR) patients by using a novel and automated assay determining dynamic thiol/disulfide homeostasis. METHODS: Fifty-one patients with acute CSCR (study group) and 65 healthy individuals (control group) were enrolled in this study. Diagnosis of acute CSCR was made clinically and using spectral-domain RTVue OCT (optical coherence tomography) (Optovue, Fremont, CA)...
January 21, 2017: International Ophthalmology
Alejandra Daruich, Alexandre Matet, Laetitia Marchionno, Jean-Dominique De Azevedo, Aude Ambresin, Irmela Mantel, Francine Behar-Cohen
PURPOSE: To evaluate the influence of clinical and multimodal imaging parameters on the duration of acute central serous chorioretinopathy (CSCR) episodes. METHODS: Consecutive patients with first, treatment-naïve central serous chorioretinopathy episodes presenting within 20 days of symptoms onset were prospectively included. They were reevaluated 15 days to 20 days later, followed by monthly evaluation for 6 months. Subfoveal choroidal thickness (SFCT), fluorescein leakage intensity on fluorescein angiography, elevation of retinal pigment epithelium (RPE) lesions at leakage sites, focal/multifocal pattern of indocyanine green angiography (ICGA) at baseline, time-dependent pattern of subretinal fluid (SRF) resorption on OCT using volume segmentation, history of corticosteroid intake and mean blood pressure were evaluated using univariate (Log rank test) and multivariate (Cox proportional hazard regression) survival analysis...
January 6, 2017: Retina
Xuemei Zhu, Yong Cheng, Xue Pan, Enzhong Jin, Shanshan Li, Mingwei Zhao, Xiaoxin Li
BACKGROUND AND OBJECTIVE: Central serous chorioretinopathy (CSCR) is a common and idiopathic retinal disorder that affects young to middle aged adults. The aim of this study was to describe the characteristics of eyes with CSCR using a light-emitting diode (LED)-based multispectral imaging (MSI) system and to evaluate the diagnostic reliability of MSI compared to fluorescein angiography (FA) in detecting CSCR. MATERIALS AND METHODS: A total of 56 eyes among 52 patients with 1 or more retinal pigment epithelium (RPE) abnormality were retrospectively enrolled in the study...
December 21, 2016: Lasers in Surgery and Medicine
Dong Yang, Dean Eliott
Central serous chorioretinopathy (CSCR) is a challenging disease characterized by subretinal serous fluid accumulation. The complex pathogenesis is still not fully understood, but is thought to be multifactorial and involves exogenous and endogenous factors affecting the choroid and retinal pigment epithelium. The involvement of corticosteroids is undisputed, while the contribution of mineralocorticoid pathways is under investigation. This review addresses the proposed pathogenesis models and the evidence for systemic treatment of CSCR with mineralocorticoid antagonists...
2017: Seminars in Ophthalmology
Muhammad Saim Khan, Murtaza Sameen, Arshad Ali Lodhi, Munawar Ahmed, Noman Ahmed, Mustafa Kamal, Sameen Afzal Junejo
OBJECTIVES: To evaluate the effect of half adult dose of oral Rifampicin on mean change in best corrected visual acuity and central macular thickness in patients with central serous chorioretinopathy. METHODS: Thirty-eight eyes of 31 patients with idiopathic central serous chorioretinopathy (CSCR) were registered. Unaided Visual acuity, best corrected visual acuity was documented and detailed slit lamp examination along with dilated ophthalmoscopy was performed...
September 2016: Pakistan Journal of Medical Sciences Quarterly
Caio V Regatieri, Eduardo A Novais, Lauren Branchini, Mehreen Adhi, Emily D Cole, Ricardo Louzada, Mark Lane, Elias Reichel, Jay S Duker
BACKGROUND: To investigate the choroidal thickness in older patients with central serous chorioretinopathy (CSCR) compared to age-matched normal subjects. METHODS: Fifteen patients (30 eyes) with CSCR, all aged ≥60 years, and 21 age-matched normal subjects (21 eyes) underwent high-definition raster scanning using SD-OCT. Both eyes from CSCR patients were included in the analysis. The eyes in patients with CSCR were divided into two groups: active CSCR (17 eyes) if there was foveal-involving subretinal fluid and inactive contralateral eye group (13 eyes)...
2016: International Journal of Retina and Vitreous
Yong Chai, Rong-Qiang Liu, Jing-Lin Yi, Ling-Hong Ye, Jing Zou, Nan Jiang, Yi Shao
AIM: To compare the effectiveness of combined fenofibrate and spironolactone with fenofibrate alone for treatment of central serous chorioretinopathy (CSCR). METHODS: Totally 60 patients (60 eyes) with a history of acute CSCR were randomed into two groups: group A with combination of fenofibrate (200 mg) and spironolactone (100 mg), and group B with only fenofibrate (200 mg). They were taken half an hour before meals and once per day for 8wk. The changes of the visual acuity, subjective symptom, ocular surface disease index (OSDI), the tear film and optical coherence tomography were observed at 2, 4, 6, and 8wk before and after treatment...
2016: International Journal of Ophthalmology
Francesco Pichi, Paola Carrai, Antonio Ciardella, Francine Behar-Cohen, Paolo Nucci
PURPOSE: To evaluate the effect of oral spironolactone and eplerenone, two specific antagonists of the mineralocorticoid receptor, in central serous chorioretinopathy (CSCR). METHODS: In this prospective, placebo-controlled trial, sixty patients with persistent CSCR were assigned to three treatment group. Twenty patients in Group 1 were treated with 25 mg of spironolactone (Aldactone; Pfizer) for 1 week, then increased to 50 mg for the following 3 weeks, then shifted to eplerenone 50 mg for 1 month...
October 18, 2016: International Ophthalmology
Pradeep Venkatesh, Rohan Chawla, Koushik Tripathy, Harsh Inder Singh, Ravi Bypareddy
BACKGROUND: Effective therapeutic options are limited for the management of chronic central serous chorioretinopathy (CSCR) complicated by exudative retinal detachments (RD). The authors describe the resolution of one such case following partial thickness scleral resection with mitomycin C. CASE PRESENTATION: This 39-year-old male presented with a unilateral inferior exudative RD in the right eye. There was no history of steroid use either locally or systemically...
2016: Eye and Vision (London, England)
Qamar Ul Islam, Muhammad Kashif Hanif, Sheraz Tareen
OBJECTIVE: To determine the frequency of various systemic risk factors associated with acute central serous chorioretinopathy (CSCR) in our setup. STUDY DESIGN: Descriptive case series. PLACE AND DURATION OF STUDY: Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi, from July 2011 to June 2014. METHODOLOGY: All consecutive patients with acute CSCR who presented in the outpatient department during the study period were recruited...
August 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Rupak Roy, Kumar Saurabh, Debmalya Das, Pradeep Kumar Panigrahi, Sudipta Das, Swakshyar Saumya Pal, Amit Jain
PURPOSE: To report the visual outcome in choroidal neovascular membrane developing (CNVM) in eyes with central serous chorioretinopathy (CSCR) with our without prior focal laser. METHODS: A retrospective case series of eyes with CNVM secondary to CSCR treated with intravitreal anti-VEGF. RESULTS: Ten eyes of nine patients of CNVM with CSCR who underwent intravitreal anti-VEGF injections were analyzed. Five eyes had CNVM without prior laser photocoagulation, and five eyes developed CNVM after laser photocoagulation for CSCR...
August 17, 2016: Seminars in Ophthalmology
Frank H P Lai, Danny S Ng, Malini Bakthavatsalam, Vesta C K Chan, Alvin L Young, Fiona O J Luk, Chi Wai Tsang, Mårten E Brelén
PURPOSE: To investigate long-term efficacy and prognostic factors of half-dose photodynamic therapy (PDT) in chronic central serous chorioretinopathy (CSCR). DESIGN: Retrospective multicenter interventional case series. METHODS: Patients with chronic CSCR undergoing half-dose PDT between 2005 and 2011 were reviewed. Main outcome measures included resolution of serous retinal detachment (SRD) with single PDT, change in best-corrected visual acuities (BCVAs), and recurrence rate of CSCR at 36 months after PDT...
October 2016: American Journal of Ophthalmology
Ayako Yasui, Manabu Yamamoto, Kumiko Hirayama, Kunihiko Shiraki, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, Takeya Kohno
PURPOSE: To assess retinal sensitivity after selective retina therapy (SRT) in patients with central serous chorioretinopathy (CSCR). METHODS: Seventeen eyes of 17 patients with CSCR lasting longer than 3 months were treated with SRT (wavelength 527 nm Nd: YLF laser, 50-150 μJ/pulse, spot diameter 200 μm). Measurement of best-corrected visual acuity (BCVA), optical coherence tomography, fluorescence angiography, and microperimetry (MAIA™) were conducted before, and 1 and 3 months after treatment...
February 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Tina Rike Herold, Kristina Rist, Siegfried Georg Priglinger, Michael Werner Ulbig, Armin Wolf
PURPOSE: To evaluate the long-term results of spironolactone in non-resolving central serous chorio-retinopathy (CSCR) and recurrence rates of CSCR. METHODS: Interventional uncontrolled open-label prospective clinical trial of patients with non-resolving CSCR who were treated with spironolactone 50 mg daily (Spironolacton AL® 50 mg, ALIUD PHARMA) for up to 16 weeks. Follow-up visits were performed at 3, 6, 9, and 12 months. Retreatment criteria for recurrence were: gain in sub-retinal fluid (SRF) of more than 25 % plus/or increase of central retinal thickness (CRT) of more than 50 μm plus visual symptoms compared to last visit...
February 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Zaid Mammo, Farzin Forooghian
PURPOSE: To describe the incidence and features of acute exudative maculopathy (AEM) after half-fluence photodynamic therapy (PDT) and/or very minimal fluence PDT. METHODS: Retrospective chart review of all patients treated over a 7-year period. RESULTS: A total of 52 patients (58 eyes, 140 treatments) were treated with half-fluence PDT and/or very minimal fluence PDT. Patients were diagnosed with either central serous chorioretinopathy (CSCR) or neovascular age-related macular degeneration (nAMD)...
July 1, 2016: Retinal Cases & Brief Reports
Gülizar Demirok, Fatih Kocamaz, Yasemin Topalak, Yeşim Altay, Ahmet Sengun
Central serous chorioretinopathy (CSCR) is characterized by neurosensory retinal detachment. Because the retina pigment epithelium and choroidal pathology is the current mechanism in CSCR, many studies in the literature focused on the outer retinal layers. There is little information about the functional or histological structure of the detached retina. In this study, we assess the ganglion cell complex (GCC) thickness using optical coherence tomography (OCT) in patients with acute and chronic CSCR. The medical records of 16 acute and 19 chronic CSCR patients which have no other disorders that cause a serous macula detachment were analyzed...
April 2017: International Ophthalmology
M Sampo, V Soler, P Gascon, G Ho Wang Yin, L Hoffart, D Denis, F Matonti
PURPOSE: To evaluate the efficacy of eplerenone, a mineralocorticoid receptor antagonist, in the treatment of chronic central serous chorioretinopathy (CSCR). MATERIALS AND METHODS: We conducted a retrospective study of 27 patients treated with eplerenone for chronic CSCR of at least 3 months duration. For each patient, visual acuity and macular OCT (central retinal thickness, height of foveal subretinal fluid (SRF), central choroidal thickness) were evaluated before treatment and at 1 month and 3 months...
June 2016: Journal Français D'ophtalmologie
Ana Lívia Gomes-Cornélio, Elisandra Márcia Rodrigues, Leticia Boldrin Mestieri, Thaís de Oliveira Rodrigues Sanzovo Falcoski, Christiane Pienna Soares, Juliane Maria Guerreiro-Tanomaru, Carlos Rossa, Mário Tanomaru
Several calcium silicate-based biomaterials have been developed in recent years, in addition to Mineral Trioxide Aggregate (MTA). The aim of this study was to evaluate the cytotoxicity, genotoxicity and apoptosis/necrosis in human osteoblast cells (SAOS-2) of pure calcium silicate-based cements (CSC) and modified formulations: modified calcium silicate-based cements (CSCM) and three resin-based calcium silicate cements (CSCR1) (CSCR 2) (CSCR3). The following tests were performed after 24 hours of cement extract exposure: methyl-thiazolyl tetrazolium (MTT), apoptosis/necrosis assay and comet assay...
May 20, 2016: Brazilian Oral Research
Sailaja Bondalapati, Avinash Pathengay, Jay Chhablani
BACKGROUND: To report the outcomes of external drainage of subretinal fluid (SRF) in exudative retinal detachment secondary to central serous chorioretinopathy (CSCR). METHODS: Retrospective observational analysis of six eyes with exudative retinal detachment secondary to CSCR who underwent external drainage of SRF between 2004 and 2014 was performed. Collected data included demographics, steroid usage, surgical details, and visual acuity preoperatively and postoperative visual acuity and clinical examination data were collected...
December 2015: Eye Science
Cihan Ünlü, Gurkan Erdogan, Tugba Aydogan, Betul Ilkay Sezgin Akcay, Esra Kardes, Gulunay Akcali Kiray, Tahir Kansu Bozkurt
PURPOSE: To compare the outcomes of treatment with intravitreal bevacizumab (IVB) versus observation in central serous chorioretinopathy (CSCR). METHODS: In a retrospective comparative study, records of 45 patients with CSCR were reviewed. Twenty-two patients received IVB (1.25 mg/0.05 ml) while 23 subjects were observed. All subjects underwent measurement of best corrected visual acuity (BCVA) and intraocular pressure (IOP), dilated fundus examination and optical coherence tomography (OCT) imaging at baseline and follow up visits...
January 2016: Journal of Ophthalmic & Vision Research
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