Yan Liu, Xiqing Luo, Ye Chen, Junlong Dang, Donglan Zeng, Xinghua Guo, Weizhen Weng, Jun Zhao, Xiaoyi Shi, Jingrong Chen, Bo Dong, Shuyuan Zhong, Jianhua Ren, Yuhang Li, Julie Wang, Jingwen Zhang, Jianbo Sun, Hanshi Xu, Yan Lu, David Brand, Song Guo Zheng, Yunfeng Pan
Focal iron overload is frequently observed in patients with rheumatoid arthritis (RA), yet its functional significance remains elusive. Herein, we report that iron deposition in lesion aggravates arthritis by inducing macrophage ferroptosis. We show that excessive iron in synovial fluid positively correlates with RA disease severity as does lipid hyperoxidation of focal monocyte/macrophages. Further study reveals high susceptibility to iron induced ferroptosis of the anti-inflammatory macrophages M2, while pro-inflammatory M1 are less affected...
December 20, 2023: Redox Biology