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https://www.readbyqxmd.com/read/29656610/fipronil-recognition-by-the-fa1-site-of-human-serum-albumin
#1
Paolo Ascenzi, Loris Leboffe, Daniele Toti, Fabio Polticelli, Viviana Trezza
Fipronil is a broad-spectrum pesticide widely used in agriculture, horticulture, and forestry. Because fipronil can cause a variety of toxic effects in animals and humans, its use is authorized as a pesticide in veterinary medicinal products for pets, but not for the treatment of livestock animals whose products are intended for consumption. Recently, however, the presence of fipronil residues has been detected in the eggs and meat of layer hens from farms located in different European countries. Given the relevance of fipronil toxicity for human health, it is important to gain information concerning its fate in the human body, including its binding mode to human serum albumin (HSA), the most abundant protein in plasma...
April 15, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29656535/uterine-and-eggshell-modifications-associated-with-the-evolution-of-viviparity-in-south-american-water-snakes-helicops-spp
#2
Henrique B Braz, Selma M Almeida-Santos, Christopher R Murphy, Michael B Thompson
The evolution of viviparity requires eggshell thinning to bring together the maternal uterus and extraembryonic membranes to form placentae for physiological exchanges. Eggshell thinning likely involves reduced activity of the uterine glands that secrete it. We tested these hypotheses by comparing the uterine and eggshell structure and histochemistry among oviparous and viviparous water snakes (Helicops) using phylogenetic methods. Eggshell thinning occurred convergently in all three origins of viviparity in Helicops and was accomplished by the loss of the mineral layer and thinning of the shell membrane...
April 14, 2018: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/29656491/recurrent-f8-and-f9-gene-variants-result-from-a-founder-effect-in-two-large-french-haemophilia-cohorts
#3
F Lassalle, O Marmontel, C Zawadzki, M Fretigny, P Bouvagnet, C Vinciguerra
INTRODUCTION: Haemophilia A (HA) and haemophilia B (HB) are X-linked recessive diseases, caused by a large number of pathogenic variants in the F8 and F9 genes. With the exception of introns 22 and 1 inversions which are frequent in severe HA cases, about 2000 unique variants in F8 and 1000 in F9 have been described in databases and their recurrence remains limited. AIM AND METHODS: During routine analysis, we identified two recurrent missense variants, the F8 gene c...
April 14, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29656490/cross-cultural-adaptation-reliability-and-validity-of-the-spanish-version-of-the-neonatal-skin-risk-assessment-scale
#4
Pablo García-Molina, Evelin Balaguer López, José Verdú, Andreu Nolasco, Francisco P García Fernández
AIM: To adapt the Neonatal Skin Risk Assessment Scale to the Spanish context and to test its validity and reliability. BACKGROUND: Currently, in Spain there are no validated scales to evaluate the risk of pressure ulcers in infants. METHOD: The research was performed in 10 neonatal units. Overall, we use an observational study design, but divided it in to three stages. In the first stage, the transcultural adaptation of the scale and its content validation was performed...
April 14, 2018: Journal of Nursing Management
https://www.readbyqxmd.com/read/29656482/kindlin-3-negatively-regulates-the-release-of-neutrophil-extracellular-traps
#5
Zhen Xu, Beiwen Ni, Zhongyuan Cao, Jacek Zielonka, Juan Gao, Fangyuan Chen, Balaraman Kalyanaraman, Gilbert C White, Yan-Qing Ma
Neutrophils fight infections by generating reactive oxygen species (ROS) and extracellular traps (NETs). However, how neutrophils modulate ROS/NET generation is mechanistically unclear. Kindlin-3, an essential integrin activator expressed in hematopoietic cells, is required to support integrin-mediated neutrophil recruitment during inflammation. Here, we report a novel role of kindlin-3 in regulating ROS/NET generation in neutrophils. When overexpressing kindlin-3 in neutrophil-like differentiated HL-60 cells (HL-60N), ROS/NET generation from these cells were significantly suppressed...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29656469/mortality-and-nursing-home-placement-of-dementia-patients-in-rural-and-urban-areas-a-cohort-study-from-the-swedish-dementia-registry
#6
Mandy Roheger, Eva Zupanic, Ingemar Kåreholt, Dorota Religa, Elke Kalbe, Maria Eriksdotter, Sara Garcia-Ptacek
BACKGROUND: Life in rural and urban areas differs in regard to social support and health care. Our aim was to examine the association between nursing home placement and survival of patients with dementia living in urban vs. rural areas. METHODS: We performed a longitudinal cohort study of patients with dementia at time of diagnosis (n = 58 154) and at first follow-up (n = 21 522) including patients registered from 2007 through 2014 in the Swedish Dementia Registry (SveDem)...
April 14, 2018: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/29656446/hemodynamic-response-function-hrf-variability-confounds-resting-state-fmri-functional-connectivity
#7
D Rangaprakash, Guo-Rong Wu, Daniele Marinazzo, Xiaoping Hu, Gopikrishna Deshpande
PURPOSE: fMRI is the convolution of the hemodynamic response function (HRF) and unmeasured neural activity. HRF variability (HRFv) across the brain could, in principle, alter functional connectivity (FC) estimates from resting-state fMRI (rs-fMRI). Given that HRFv is driven by both neural and non-neural factors, it is problematic when it confounds FC. However, this aspect has remained largely unexplored even though FC studies have grown exponentially. We hypothesized that HRFv confounds FC estimates in the brain's default-mode-network...
April 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29656444/predicting-therapeutic-response-to-fingolimod-treatment-in-multiple-sclerosis-patients
#8
Bibiana Quirant-Sánchez, José V Hervás-García, Aina Teniente-Serra, Luis Brieva, Ester Moral-Torres, Antonio Cano, Elvira Munteis, María J Mansilla, Silvia Presas-Rodriguez, Juan Navarro-Barriuso, Cristina Ramo-Tello, Eva M Martínez-Cáceres
AIMS: Fingolimod, an orally active immunomodulatory drug for relapsing-remitting multiple sclerosis (RRMS), sequesters T cells in lymph nodes through functional antagonism of the sphingosine-1-phosphate receptor, reducing the number of potential autoreactive cells that migrate to the central nervous system. However, not all RRMS patients respond to this therapy. Our aim was to test the hypothesis that by immune-monitoring RRMS patient's leukocyte subpopulations it is possible to find biomarkers associated with clinical response to fingolimod...
April 15, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29656429/citalopram-attenuated-neurobehavioral-biochemical-and-metabolic-alterations-in-transient-middle-cerebral-artery-occlusion-model-of-stroke-in-male-wistar-rats
#9
Sangeetha Gupta, Deepti Upadhayay, Uma Sharma, Naranamangalam R Jagannathan, Yogendra Kumar Gupta
Oxidative stress and inflammation are implicated as cardinal mechanisms of neuronal death following stroke. In the present study citalopram (Cit) was investigated in a 2 h middle cerebral artery occlusion (MCAo) model of stroke in male Wistar rats. Pretreatment, posttreatment (Post Cit) and pre plus posttreatment (Pre + Post Cit) with Cit were evaluated for its neuroprotective effect. In pretreatment protocol, effect of Cit at three doses (2, 4, and 8 mg/kg) administered i.p., 1 h prior to MCAo was evaluated using neurological deficit score (NDS), motor deficit paradigms, and cerebral infarction 24 h post-MCAo...
April 15, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29656423/interdisciplinary-knowledge-exchange-across-scales-in-a-globally-changing-marine-environment
#10
Karlie S McDonald, Alistair J Hobday, Elizabeth A Fulton, Peter A Thompson
The effects of anthropogenic global environmental change on biotic and abiotic processes have been reported in aquatic systems across the world. Complex synergies between concurrent environmental stressors and the resilience of the system to regime shifts, which vary in space and time, determine the capacity for marine systems to maintain structure and function with global environmental change. Consequently, an interdisciplinary approach that facilitates the development of new methods for the exchange of knowledge between scientists across multiple scales is required to effectively understand, quantify and predict climate impacts on marine ecosystem services...
April 14, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29656421/effect-of-cleaning-methods-on-retentive-values-of-saliva-contaminated-implant-supported-zirconia-copings
#11
Farahnaz Nejatidanesh, Omid Savabi, Ghazal Savabi, Mehdi Razavi
OBJECTIVE: The aim of this study was to evaluate the effect of different cleaning regimens on retentive strength of saliva-contaminated implant-supported zirconia copings. MATERIAL AND METHODS: Seventy solid titanium abutments with 5.5 mm height (Straumann) were attached to the regular neck implant analogs (Straumann). The abutment-analog complex was mounted vertically in an autopolymerized T-shaped acrylic resin block. Seventy zirconia copings with an occlusal loop were made...
April 15, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29656420/spatially-confined-assembly-of-monodisperse-ruthenium-nanoclusters-in-a-hierarchically-ordered-carbon-electrode-for-efficient-hydrogen-evolution
#12
Zhong-Li Wang, Keju Sun, Joel Henzie, Xianfeng Hao, Cuiling Li, Toshiaki Takei, Yong-Mook Kang, Yusuke Yamauchi
The redox units of polyaniline (PAni) are used cooperatively, and in situ, to assemble ruthenium (Ru) nanoclusters in a hierarchically ordered carbon electrode. The oxidized quinonoid imine (QI) units in PAni bond Ru complex ions selectively, whereas reduced benzenoid amine (BA) units cannot. By electrochemically tuning the ratio of QI to BA, Ru complexes are spatially confined in the outer layer of hierarchical PAni frameworks. Carbonization of Ru-PAni hybrids induces nucleation on the outer surface of the carbon support, generating nearly monodisperse Ru nanoclusters...
April 14, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29656415/focusing-on-cancer-patients-intentions-to-use-psycho-oncological-support-a-longitudinal-mixed-methods-study
#13
T Tondorf, A Grossert, S I Rothschild, M T Koller, C Rochlitz, A Kiss, R Schaefert, G Meinlschmidt, S Hunziker, D Zwahlen
OBJECTIVE: Distress screening programs aim to ensure appropriate psycho-oncological support for cancer patients, but many eligible patients do not use these services. To improve distress management, we need to better understand patients' supportive care needs. In this paper, we report the first key finding from a longitudinal study that focused on patients' intentions to use psycho-oncological support, and its association with distress and uptake of the psycho-oncology service. METHODS: We conducted a prospective, observational study in an Oncology Outpatient Clinic and assessed distress, intention to use psycho-oncological support, and uptake of the psycho-oncology service using the Distress Thermometer (DT), a semi-structured interview, and hospital records...
April 15, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29656408/in-silico-tracking-of-individual-species-accelerating-progress-in-macromolecular-engineering-and-design
#14
Dagmar R D'hooge
The beneficial use of computer simulations to track the microstructural evolution of individual species is highlighted in view of macromolecular engineering and design, considering two case studies on catalytic polymerization, and both "low" (<100) and "high" (>100) chain lengths, that is, i) atom transfer radical copolymerization of n-butyl acrylate and styrene aiming at the synthesis of functional macrospecies of "identical' chain length; and ii) chain shuttling polymerization of ethylene and 1-octene toward the production of segmented block copolymers with "soft" and "hard" segments...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656384/supporting-mentoring-relationships-of-youth-in-foster-care-do-program-practices-predict-match-length
#15
Rebecca L Stelter, Janis B Kupersmidt, Kathryn N Stump
Implementation of research- and safety-based program practices enhance the longevity of mentoring relationships, in general; however, little is known about how mentoring programs might support the relationships of mentees in foster care. Benchmark program practices and Standards in the Elements of Effective Practice for Mentoring, 3rd Edition (MENTOR, 2009) were assessed in the current study as predictors of match longevity. Secondary data analyses were conducted on a national agency information management database from 216 Big Brothers Big Sisters agencies serving 641 youth in foster care and 70,067 youth not in care from across the United States (Mean = 11...
April 15, 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29656381/cowpea-an-overview-on-its-nutritional-facts-and-health-benefits
#16
REVIEW
Chathuni Jayathilake, Rizliya Visvanathan, Afka Deen, Ruksheela Bangamuwage, Barana C Jayawardana, Srinivas Nammi, Ruvini Liyanage
Cowpea (Vigna unguiculata) is a legume consumed as a high-quality plant protein source in many parts of the world. High protein and carbohydrate contents with relatively low fat content and complementary amino acid pattern to that of cereal grains make cowpea an important nutritional food in the human diet. Cowpea has gained more attention recently from consumers and researchers worldwide due to its exerted health beneficial properties including anti-diabetic, anti-cancer, anti-hyperlipidemic, anti-inflammatory and anti-hypertensive properties...
April 15, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29656373/evaluation-of-disease-activity-in-patients-with-rheumatoid-arthritis-treated-with-tofacitinib-by-rapid3-post-hoc-analyses-from-two-phase-3-trials
#17
Vibeke Strand, Eun Bong Lee, Yusuf Yazici, Ara Dikranian, Bethanie Wilkinson, Liza Takiya, Chuanbo Zang, Eustratios Bananis, Martin J Bergman
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. We evaluated the relationship between disease activity, according to Routine Assessment of Patient Index Data 3 (RAPID3) after 6-month treatment with tofacitinib, and long-term outcomes at 24 months. This was a post hoc analysis of two 24-month, phase 3, randomized controlled trials in methotrexate (MTX)-naïve (ORAL Start [NCT01039688]) or MTX-inadequate responder patients (ORAL Scan [NCT00847613]) receiving tofacitinib 5 or 10 mg twice daily (BID) as monotherapy or with background MTX...
April 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29656360/dietary-vitamin-e-status-dictates-oxidative-stress-outcomes-by-modulating-effects-of-fish-oil-supplementation-in-alzheimer-disease-model-app-swe-ps1-de9-mice
#18
Shengqi Dong, Xiaochen Huang, Jie Zhen, Nicholas Van Halm-Lutterodt, JiaJia Wang, Cui Zhou, Linhong Yuan
Quite a number of studies have examined the effects of fish oil supplementation on cognitive performance in different transgenic animal models of Alzheimer's disease (AD). However, inconsistent and controversial outcomes have been derived from these experiments. In order to investigate whether the beneficial effect of fish oil supplementation on cognition was dietary VE status associated, fish oil dietary intervention was carried out in transgenic APPswe /PS1dE9 (APP/PS1) mice. Control mice (C57BL/6J mice) were fed a normal control diet...
April 14, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29656301/septoplasty-for-nasal-obstruction-due-to-a-deviated-nasal-septum-in-adults-a-systematic-review
#19
M M H T van Egmond, M M Rovers, A H J Tillema, N van Heerbeek
BACKGROUND: The status of current evidence for the effectiveness of septoplasty is unclear. This systematic review evaluates the effectiveness of a) septoplasty (with or without concurrent turbinate surgery) versus non-surgical management, and b) septoplasty with concurrent turbinate surgery versus septoplasty alone, for nasal obstruction due to a deviated nasal septum in adults. METHODOLOGY: Eligible for inclusion were randomised controlled trials and non-randomised designs comparing treatment strategies...
April 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29656263/early-improvement-as-a-predictor-of-final-remission-in-major-depressive-disorder-new-insights-in-electroconvulsive-therapy
#20
Erika Martínez-Amorós, Ximena Goldberg, Verònica Gálvez, Aida de Arriba-Arnau, Virginia Soria, José M Menchón, Diego J Palao, Mikel Urretavizcaya, Narcís Cardoner
BACKGROUND: Early improvement to antidepressant drugs predicts remission, but the predictive value of early improvement to electroconvulsive therapy (ECT) is still unclear. The main aim of this study was to determine the optimal definition of early improvement in the treatment of major depressive disorder (MDD) with ECT, by analyzing its value as a predictor of remission. METHODS: A naturalistic study was conducted in 87 adult MDD patients treated with acute ECT...
April 6, 2018: Journal of Affective Disorders
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