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https://www.readbyqxmd.com/read/29041034/inhaled-versus-systemic-corticosteroids-for-preventing-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-neonates
#1
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: Bronchopulmonary dysplasia (BPD) remains an important cause of mortality and morbidity in preterm infants and inflammation plays a significant role in its pathogenesis. The use of inhaled corticosteroids may modulate the inflammatory process without concomitant high systemic steroid concentrations and less risk of adverse effects. This is an update of a review published in 2012 (Shah 2012). We recently updated the related review on "Inhaled versus systemic corticosteroids for treating bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates"...
October 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29041005/cardiogenic-shock-during-first-infusion-of-anthracycline-chemotherapy-in-a-patient-with-hodgkin-lymphoma-an-unusual-event
#2
Giulio Binaghi, Damiana Congia, Stefano Cossa, Stefania Massidda, Daniele Pasqualucci, Federica Pilo, Emanuela Serra, Emanuele Angelucci, Maurizio Porcu
INTRODUCTION: Hodgkin lymphoma (HL) is one of the most common types of cancers of the lymphatic system. The currently available therapies enable a cure in approximately 80-85% of treated patients. However, the cardiotoxicity of HL treatment has become a major cause of morbidity and mortality in survivors mainly related to the use of anthracycline. CASE REPORT: An HL, staged IIIB, was diagnosed in a 60-year-old man with no cardiovascular disease. During the first cycle of ABVD chemotherapy (Adriamycin; bleomycin; vinblastine; dacarbazine), near the end of the dacarbazine infusion, the patient presented a sudden cardiogenic shock characterized by a severe left ventricular systolic dysfunction...
October 18, 2017: Cardiology
https://www.readbyqxmd.com/read/29040929/determination-of-geographical-origin-and-icariin-content-of-herba-epimedii-using-near-infrared-spectroscopy-and-chemometrics
#3
Yue Yang, Yongjiang Wu, Weili Li, Xuesong Liu, Jiyu Zheng, Wentao Zhang, Yong Chen
Near infrared (NIR) spectroscopy coupled with chemometrics was used to discriminate the geographical origin of Herba Epimedii in this work. Four different classification models, namely discriminant analysis (DA), back propagation neural network (BPNN), K-nearest neighbor (KNN), and support vector machine (SVM), were constructed, and their performances in terms of recognition accuracy were compared. The results indicated that the SVM model was superior over the other models in the geographical origin identification of Herba Epimedii...
October 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29040928/calorimetric-and-spectroscopic-studies-of-the-interaction-between-zidovudine-and-human-serum-albumin
#4
Adrian Pîrnău, Mihaela Mic, Silvia Neamţu, Călin G Floare, Mircea Bogdan
A quantitative analysis of the interaction between zidovudine (AZT) and human serum albumin (HSA) was achieved using Isothermal titration calorimetry (ITC) in combination with fluorescence and (1)H NMR spectroscopy. ITC directly measure the heat during a biomolecular binding event and gave us thermodynamic parameters and the characteristic association constant. By fluorescence quenching, the binding parameters of AZT-HSA interaction was determined and location to binding site I of HSA was confirmed. Via T1 NMR selective relaxation time measurements the drug-protein binding extent was evaluated as dissociation constants Kd and the involvement of azido moiety of zidovudine in molecular complex formation was put in evidence...
October 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29040908/predicting-lysine-glycation-sites-using-bi-profile-bayes-feature-extraction
#5
Zhe Ju, Juhe Sun, Yanjie Li, Li Wang
Glycation is a nonenzymatic post-translational modification which has been found to be involved in various biological processes and closely associated with many metabolic diseases. The accurate identification of glycation sites is important to understand the underlying molecular mechanisms of glycation. As the traditional experimental methods are often labor-intensive and time-consuming, it is desired to develop computational methods to predict glycation sites. In this study, a novel predictor named BPB_GlySite is proposed to predict lysine glycation sites by using bi-profile bayes feature extraction and support vector machine algorithm...
October 12, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29040884/heart-rate-variability-feature-selection-in-the-presence-of-sleep-apnea-an-expert-system-for-the-characterization-and-detection-of-the-disorder
#6
Sofía Martín-González, Juan L Navarro-Mesa, Gabriel Juliá-Serdá, Jan F Kraemer, Niels Wessel, Antonio G Ravelo-García
We introduce a sleep apnea characterization and classification approach based on a Heart Rate Variability (HRV) feature selection process, thus focusing on the characterization of the underlying process from a cardiac rate point of view. Therefore, we introduce linear and nonlinear variables, namely Cepstrum Coefficients (CC), Filterbanks (Fbank) and Detrended Fluctuation Analysis (DFA). Logistic Regression, Linear Discriminant Analysis and Quadratic Discriminant Analysis were used for classification purposes...
October 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29040883/veno-arterial-extracorporeal-membrane-oxygenation-va-ecmo-for-emergency-cardiac-support
#7
Terri Sun, Andrew Guy, Amandeep Sidhu, Gordon Finlayson, Brian Grunau, Lillian Ding, Saida Harle, Leith Dewar, Richard Cook, Hussein D Kanji
PURPOSE: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may provide benefit to patients in refractory cardiac arrest and cardiogenic shock. We aim to summarize our center's 6-year experience with resuscitative VA-ECMO. MATERIALS AND METHODS: A retrospective medical record review (April 2009 to 2015) was performed on consecutive non-cardiotomy patients who were managed with VA-ECMO due to refractory in- or out-of-hospital cardiac (IHCA/OHCA) arrest (E-CPR) or refractory cardiogenic shock (E-CS) with or without preceding cardiac arrest...
October 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29040880/prolonged-parturition-and-impaired-placenta-expulsion-increase-the-risk-of-postpartum-metritis-and-delay-uterine-involution-in-sows
#8
S Björkman, C Oliviero, J Kauffold, N M Soede, O A T Peltoniemi
It was hypothesized that prolonged parturition and impaired placenta expulsion increase the risk of postpartum metritis and delay uterine involution. At parturition, for 99 Yorkshire x Large White sows (parity 2-5), we determined the number of liveborn (NLP; 14.8 ± 3.4) and stillborn piglets (NSP; 1.1 ± 1.1), farrowing duration (FAR, time between first and last piglet; 333 ± 249 min), placenta expulsion duration (PLA, time between first and last placental part; 292 ± 241 min) and number of expelled placental parts (PART; 3...
October 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/29040855/technoeconomic-analysis-of-biojet-fuel-production-from-camelina-at-commercial-scale-case-of-canadian-prairies
#9
Xue Li, Edmund Mupondwa, Lope Tabil
This study undertakes technoeconomic analysis of commercial production of hydro-processed renewable jet (HRJ) fuel from camelina oil in the Canadian Prairies. An engineering economic model designed in SuperPro Designer® investigated capital investment, scale, and profitability of producing HRJ and co-products (biodiesel, naphtha, LPG, and propane) based on biorefinery plant sizes of 112.5-675 million L annum(-1). Under base case scenario, the minimum selling price (MSP) of HRJ was $1.06 L(-1) for a biorefinery plant with size of 225 million L...
September 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29040847/characterization-of-ionic-liquid-pretreated-plant-cell-wall-for-improved-enzymatic-digestibility
#10
Tirath Raj, Ruchi Gaur, Bhawna Yadav Lamba, Nitu Singh, Ravi P Gupta, Ravindra Kumar, Suresh K Puri, S S V Ramakumar
An insight into the properties of cell wall of mustard stalk (MS) pretreated by five ionic liquids (ILs) revealed ILs interaction with cellulose, hemicellulose and lignin components. Differential Scanning Calorimetry (DSC) showed increased pore size coupled with increased population of pores evoked by certain ILs in better facilitating enzymatic accessibility. Interestingly, all the five ILs predominantly increased the propensity of two pore sizes formation; 19 and 198 nm, but remarkable difference in the pore volumes of pretreated MS suggested the supremacy of [OAc](-) based ILs, resulting in higher glucose yields...
October 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29040825/comparing-the-predictive-validity-of-the-four-factor-and-five-factor-bifactor-measurement-structures-of-the-drinking-motives-questionnaire
#11
Andrew Lac, Candice D Donaldson
INTRODUCTION: The Drinking Motives Questionnaire (DMQ-R) is the most widely administered instrument to assess reasons for consuming alcohol and is conventionally premised on a four-factor structure. Recent research instead reveals that a bifactor measurement model of five motive factors (one general and four specific) represents a superior psychometric embodiment of the scale. The current study evaluated and compared the predictive validity of the four-factor and five-factor models of drinking motives in longitudinally explaining alcohol use and problems...
October 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29040811/mobile-emergency-simulation-training-for-rural-health-providers
#12
Douglas Martin, Brent Bekiaris, Gregory Hansen
INTRODUCTION: Mobile emergency simulation offers innovative continuing medical educational support to regions that may lack access to such opportunities. Furthermore, satisfaction is a critical element for active learning. Together, the authors evaluated Canadian rural healthcare providers' satisfaction from high fidelity emergency simulation training using a modified motorhome as a mobile education unit (MEU). METHODS: Over a 5-month period, data was collected during 14 educational sessions in nine different southern Manitoban communities...
July 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/29040801/molecular-level-insight-into-the-interaction-of-phospholipid-bilayers-with-cellulose
#13
Andrei Yu Kostritskii, Dmitry Alekseevich Tolmachev, Natalia Viacheslavovna Lukasheva, Andrey A Gurtovenko
A molecular-level insight into the interactions of phospholipid molecules with cellulose is crucial for the development of novel cellulose-based materials for wound dressing. Here we employ the state-of-the-art computer simulations to unlock for a first time the molecular mechanisms behind such interactions. To this end, we performed a series of atomic-scale molecular dynamics simulations of phospholipid bilayers on a crystalline cellulose support at various hydration levels of the bilayer leaflets next to the cellulose surface...
October 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29040797/attention-deficit-hyperactivity-disorder-symptoms-and-psychosis-in-22q11-2-deletion-syndrome
#14
Maria Niarchou, Monica E Calkins, Tyler M Moore, Sunny X Tang, Donna M McDonald-McGinn, Elaine H Zackai, Beverly S Emanuel, Ruben C Gur, Raquel E Gur
OBJECTIVE: 22q11.2 Deletion Syndrome (22q11.2DS) is associated with increased risk for schizophrenia in adulthood while Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent diagnosis in childhood. Inattention symptoms are pronounced in 22q11.2DS and given that attentional impairment is a core feature of schizophrenia, inattention symptoms may reflect underlying ADHD, psychosis, or both. We investigate whether inattention is associated with psychosis in 22q11.2DS and in other groups at risk for psychosis but without the deletion (ND) (idiopathic clinical risk and first degree family members of individuals with schizophrenia)...
October 10, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29040791/roles-of-mmu_pir_003399-in-microcystin-leucine-arginine-mc-lr-induced-reproductive-toxicity-in-the-spermatogonial-cells-and-testis
#15
Ling Zhang, Xiannan Meng, Zou Xiang, Dongmei Li, Xiaodong Han
Our previous work has demonstrated that microcystin-leucine arginine (MC-LR) is a potent toxin for the reproductive system of male mice and it exerts cytotoxicity in spermatogonial cells, resulting in the constitutional and functional changes of the mouse testis. The present study was designed to investigate the functions of P-element-induced wimpy (piwi)-interacting RNAs (piRNAs) in MC-LR-induced reproductive toxicity in male mice. We observed an increase in the mmu_piR_003399 level in spermatogonial cells and mouse testicular tissues following treatment with MC-LR...
October 12, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29040771/contrasting-ecophysiological-strategies-related-to-drought-the-case-of-a-mixed-stand-of-scots-pine-pinus-sylvestris-and-a-submediterranean-oak-quercus-subpyrenaica
#16
Paula Martín-Gómez, Mònica Aguilera, Jesús Pemán, Eustaquio Gil-Pelegrín, Juan Pedro Ferrio
Submediterranean forests are considered an ecotone between Mediterranean and Eurosiberian ecosystems, and are very sensitive to global change. A decline of Scots pine (Pinus sylvestris L.) and a related expansion of oak species (Quercus spp.) have been reported in the Spanish Pre-Pyrenees. Although this has been associated with increasing drought stress, the underlying mechanisms are not fully understood, and suitable monitoring protocols are lacking. The aim of this study is to bring insight into the physiological mechanisms anticipating selective decline of the pines, with particular focus on carbon and water relations...
October 13, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29040762/effects-of-schizophrenia-polygenic-risk-scores-on-brain-activity-and-performance-during-working-memory-subprocesses-in-healthy-young-adults
#17
Jacob A Miller, Matthew A Scult, Emily Drabant Conley, Qiang Chen, Daniel R Weinberger, Ahmad R Hariri
Recent work has begun to shed light on the neural correlates and possible mechanisms of polygenic risk for schizophrenia. Here, we map a schizophrenia polygenic risk profile score (PRS) based on genome-wide association study significant loci onto variability in the activity and functional connectivity of a frontoparietal network supporting the manipulation versus maintenance of information during a numerical working memory (WM) task in healthy young adults (n = 99, mean age = 19.8). Our analyses revealed that higher PRS was associated with hypoactivity of the dorsolateral prefrontal cortex (dlPFC) during the manipulation but not maintenance of information in WM (r2 = ...
October 12, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29040756/tcdd-ficz-and-other-high-affinity-ahr-ligands-dose-dependently-determine-the-fate-of-cd4-t-cell-differentiation
#18
Allison K Ehrlich, Jamie M Pennington, William H Bisson, Siva K Kolluri, Nancy I Kerkvliet
FICZ and TCDD, two high affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells. This dichotomy has been attributed to ligand-intrinsic differences in AhR activation, although differences in sensitivity to metabolism complicates the issue. TCDD is resistant to AhR-induced metabolism and produces sustained AhR activation following a single dose in the μg/kg range while FICZ is rapidly metabolized and AhR activation is transient...
October 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29040745/the-impact-of-shift-work-on-sleep-quality-among-nurses
#19
K McDowall, E Murphy, K Anderson
Background: Shift work is common among nurses, and it is known to be a workplace hazard as it may cause poor sleep quality, which can impact adversely on the health and safety of nurses and their patients. Aims: To explore factors that contribute to poor sleep quality in shift working nurses (SWNs) compared with non-shift working nurses (NSWNs) and to assess the awareness of support from occupational health. Methods: Cross-sectional study of nurses at a National Health Service (NHS) foundation trust, February to March 2016...
October 10, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29040741/identification-of-new-protein-protein-and-protein-dna-interactions-linked-with-wood-formation-in-populus-trichocarpa
#20
H Earl Petzold, Stephen B Rigoulot, Chengsong Zhao, Bidisha Chanda, Xiaoyan Sheng, Mingzhe Zhao, Xiaoyan Jia, Allan W Dickerman, Eric P Beers, Amy M Brunner
Cellular processes, such as signal transduction and cell wall deposition, are organized by macromolecule interactions. Experimentally determined protein-protein interactions (PPIs) and protein-DNA interactions (PDIs) relevant to woody plant development are sparse. To begin to develop a Populus trichocarpa Torr. & A. Gray wood interactome, we applied the yeast-two-hybrid (Y2H) assay in different ways to enable the discovery of novel PPIs and connected networks. We first cloned open reading frames (ORFs) for 361 genes markedly upregulated in secondary xylem compared with secondary phloem and performed a binary Y2H screen with these proteins...
October 10, 2017: Tree Physiology
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