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https://www.readbyqxmd.com/read/28822347/screening-and-confirmation-of-steroids-and-nitroimidazoles-in-urine-blood-and-food-matrices-sample-preparation-methods-and-liquid-chromatography-tandem-mass-spectrometric-separations
#1
Ádám Tölgyesi, Enikő Barta, Andrea Simon, Thomas J McDonald, Virender K Sharma
Veterinary drugs containing synthetic anabolic steroid and nitroimidazole active agents are not allowed for their applications in livestock of the European Union (EU). This paper presents analyses of twelve selected steroids and six nitroimidazole antibiotics at low levels (1.56μg/L-4.95μg/L and 0.17μg/kg-2.14μg/kg, respectively) in body fluids and egg incurred samples. Analyses involved clean-up procedures, high performance liquid chromatography (HPLC) separation, and tandem mass spectrometric screening and confirmatory methods...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28822299/avoidance-and-depression-vulnerability-an-examination-of-avoidance-in-remitted-and-currently-depressed-individuals
#2
Leanne Quigley, Alainna Wen, Keith S Dobson
Behavioral theories posit that depression is characterized by heightened levels of avoidance, and recent research has supported this notion. Whether avoidance persists after remission from depression is unknown, however. In this study, we investigated levels of cognitive and behavioral avoidance in remitted, currently, and never depressed individuals. We also examined relationships among avoidance and purported adaptive and maladaptive emotion regulation strategies. Remitted depressed individuals exhibited levels of cognitive and behavioral avoidance, in social and nonsocial domains, that were greater than nonclinical control individuals but lower than currently depressed individuals...
July 27, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28822263/the-most-important-factor-in-producing-clubhead-speed-in-golf
#3
Christopher Joyce
Substantial experiential research into x-factor, and to a lesser extent crunch-factor has been undertaken with the aim of increasing clubhead speed. However, a direct comparison of the golf swing kinematics associated with each 'factor' has not, and possible differences when using a driver compared to an iron. Fifteen low handicap male golfers who displayed a modern swing had their golf swing kinematic data measured when hitting their own driver and five-iron, using a 10-camera motion analysis system operating at 250Hz...
August 16, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28822228/computerized-neurocognitive-interventions-in-the-context-of-the-brain-training-controversy
#4
Rebeca Isabel García-Betances, María Fernanda Cabrera-Umpiérrez, María T Arredondo
This article presents, in the form of an analytic narrative review, a complete picture of the state-of-the-art, challenges, and perspectives in the field of information and communication technology (ICT)-based neurocognitive interventions for older adults. The narrative particularly focuses on applications aimed at mild cognitive impairment and similar age-related cognitive deficits, which are analyzed in the context of the brain training controversy. Clarifying considerations are provided about the nature and present extent of the brain training debate, regarding the possible influence it has on the support received by research and development initiatives dealing with innovative computerized neurocognitive interventions...
August 19, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28822215/family-emergency-plan-and-preparedness-among-medical-practitioners-in-zaria-nigeria
#5
Jerry Godfrey Makama, Istifanus Anekoson Joshua, Elizabeth Jerry Makama
BACKGROUND: There has been an increase in the incidence of disasters in many parts of the world. Similarly, Nigeria has witnessed a recent increase of man-made disaster events such as plane crash, fire incidents, flood, and building collapse, including bomb blast orchestrated by terrorists that often create emergency situations. Therefore, the aim of the study was to evaluate family emergency plan and preparedness among medical practitioners in Zaria. METHODS: This was a cross-sectional descriptive study (May-July, 2013) of medical practitioners in Zaria, Nigeria...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28822198/-comparison-between-ye-tianshi-and-xue-shengbai-in-treatment-of-distention-with-damp-heat
#6
Yu-Juan Li, Xiao-Yu Liu, Hou-Wang Jiang, Hong-Pei Li, Lian-Yu Xiao, Yan-Song Zhao
Ye Tianshi and Xue Shengbai were both epidemic febrile diseases specialists in same time of Qing dynasty. The Traditional Chinese Medicine Inheritance Support System was used to compare and analyze the therapeutic characteristics of these two specialists in treating damp-heat type fullness or distension in stomach. Distension is commonly caused by qi stagnation accompanied with damp-heat from internal and external factors. In treatment, separation of damp and heat and removing dampness and heat from sanjiao separately were their common therapeutic principles...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822173/-breakthrough-in-key-science-and-technologies-in-dendrobium-catenatum-industry
#7
Ji-Ping Si, Qi Wang, Zhong-Jian Liu, Jing-Jing Liu, Yi-Bo Luo
In view of the significant difficulties of propagation, planting and simple product in Dendrobium catenatum(D. officinale)industry development, a series of research were carried out. Genome study showed that D. catenatum is a specie of diploid with 38 chromosomes and 28 910 protein-coding genes. It was identified that specific genes accumulated in different organs at the transcriptome level. We got an insight into the gene regulation mechanism of the loss of the endospermous seed, the wide ecological adaptability and the synthesis of polysaccharides, which provided a theoretical basis for genetic engineering breeding and development and utilization of active pharmaceutical ingredients...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822161/-synergistic-mechanism-of-traditional-chinese-medicine-based-on-target-combination-of-pept1-and-ppar%C3%AE
#8
Lian-Sheng Qiao, Yan-Kun Chen, Gang-Gang Luo, Fang Lu, Si-Jia Liu, Gong-Yu Li, Yan-Ling Zhang
Synergistic effect is main pharmacological mechanism of traditional Chinese medicine(TCM). The research method based on the key targets combination is an important method to explore the synergistic effect of TCM. Peptide transporter 1 (PepT1) is an essential target for drug uptake into the bloodstream, accounting for about 50% of the total transporter protein content from the small intestine. Peroxisome proliferator-activated receptor α(PPARα) is the lipid-lowering target of fibrates, which have a good hypolipidemic effect by activating PPARα...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822153/-analyze-moisture-transformation-and-transport-rules-during-processing-of-paeoniae-radix-alba-by-using-low-field-nmr
#9
Wen-Juan Duan, Yue Li, Li Cui, Feng Liu, Guo-Hong Yang, Lan-Ping Guo, Xiao Wang
Moisture status and content during the processing of Paeoniae Radix Alba were studied by nuclear magnetic resonance (NMR) and nuclear magnetic resonance imaging (MRI) to investigate the changes of transverse relaxation time (T ₂) and MRI images during boiling and drying processes of Paeoniae Radix Alba. The results showed that water in Paeoniae Radix Alba fresh products was major of free water, and in the boiling process, the content of free water increased whereas the content of bound water declined. At the end of boiling, content of free water reached over 90%...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822053/colorectal-cancer-patient-s-self-efficacy-for-managing-illness-related-problems-in-the-first-2%C3%A2-years-after-diagnosis-results-from-the-colorectal-well-being-crew-study
#10
Chloe Grimmett, Joanne Haviland, Jane Winter, Lynn Calman, Amy Din, Alison Richardson, Peter W F Smith, Claire Foster
PURPOSE: There is a growing emphasis on self-management of cancer aftercare. Little is known about patient's self-efficacy (confidence) to manage illness-related problems and how this changes over time. This paper describes the patterns of self-efficacy for managing illness-related problems amongst colorectal cancer patients in the 2 years following diagnosis. METHODS: In this prospective cohort study, questionnaires were administered at baseline (pre-surgery), 3, 9, 15 and 24 months to 872 colorectal cancer patients...
August 19, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28822016/in-situ-imaging-reveals-properties-of-purinergic-signalling-in-trigeminal-sensory-ganglia-in-vitro
#11
Arletta Nowodworska, Arn M J M van den Maagdenberg, Andrea Nistri, Elsa Fabbretti
Chronic pain is supported by sterile inflammation that induces sensitisation of sensory neurons to ambient stimuli including extracellular ATP acting on purinergic P2X receptors. The development of in vitro methods for drug screening would be useful to investigate cell crosstalk and plasticity mechanisms occurring during neuronal sensitisation and sterile neuroinflammation. Thus, we studied, at single-cell level, membrane pore dilation based on the uptake of a fluorescent probe following sustained ATP-gated P2X receptor function in neurons and non-neuronal cells of trigeminal ganglion cultures from wild-type (WT) and R192Q CaV2...
August 18, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28822013/biomonitoring-of-chemicals-in-biota-of-two-wetland-protected-areas-exposed-to-different-levels-of-environmental-impact-results-of-the-previeni-project
#12
Cristiana Guerranti, Guido Perra, Eva Alessi, Davide Baroni, Dante Caserta, Donatella Caserta, Augusto De Sanctis, Emiliano Leonida Fanello, Cinzia La Rocca, Michela Mariottini, Monia Renzi, Sabrina Tait, Carlo Zaghi, Alberto Mantovani, Silvano Ettore Focardi
The PREVIENI project (funded by the Ministry of Environment) investigated the exposure to endocrine disrupters in samples of human population and environmental biota in Italy. The environmental biomonitoring considered two Italian WWF Oasis, with the aim to compare the presence and effects of endocrine disruptors in organisms from two protected natural areas, respectively, upstream and downstream a chemical emission site. Chemical analysis of pollutants' tissue levels was made on tissues from earthworm, barbell, trout, and coot, selected as bioindicator organisms...
August 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28822005/a-supply-model-for-nurse-workforce-projection-in-malaysia
#13
Zuraida Abal Abas, Mohamad Raziff Ramli, Mohamad Ishak Desa, Nordin Saleh, Ainul Nadziha Hanafiah, Nuraini Aziz, Zaheera Zainal Abidin, Abdul Samad Shibghatullah, Ahmad Fadzli Nizam Abdul Rahman, Haslinda Musa
The paper aims to provide an insight into the significance of having a simulation model to forecast the supply of registered nurses for health workforce planning policy using System Dynamics. A model is highly in demand to predict the workforce demand for nurses in the future, which it supports for complete development of a needs-based nurse workforce projection using Malaysia as a case study. The supply model consists of three sub-models to forecast the number of registered nurses for the next 15 years: training model, population model and Full Time Equivalent (FTE) model...
August 18, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28821999/developmental-neurotoxicity-of-the-hippocampus-following-in-utero-exposure-to-methylmercury-impairment-in-cell-signaling
#14
Luana Heimfarth, Jeferson Delgado, Moara Rodrigues Mignori, Daniel Pens Gelain, José Cláudio Fonseca Moreira, Regina Pessoa-Pureur
In this study, we assessed some hippocampal signaling cascades and behavioral impairments in 30-day-old rat pups prenatally exposed to methylmercury (MeHg). Pregnant rats were exposed to 1.0 or 2.0 mg/kg MeHg by gavage in alternated days from gestational day 5 until parturition. We found increased anxiety-like and decreased exploration behavior evaluated by open field test and deficit of both short- and long-term memories by novel object recognition task, respectively, in MeHg-treated pups. Downregulated PI3K/Akt/mTOR pathway and activated/hypophosphorylated (Ser9) GSK3β in MeHg-treated pups could be upstream of hyperphosphorylated Tau (Ser396) destabilizing microtubules and contributing to neural dysfunction in the hippocampus of these rats...
August 18, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28821983/negative-priming-a-meta-analysis-of-fmri-studies
#15
Zachary Yaple, Marie Arsalidou
A phenomenon termed negative priming is defined as an increase in reaction time and/or decrease in performance during instances in which current target stimuli are employed as distractor stimuli in the previous trial. A recent qualitative review on negative priming reported neural regions of interest underlined by activity within the right middle frontal gyrus and left middle temporal gyrus; however, these areas of interest have not been tested and supported by using coordinate-based, quantitative meta-analysis...
August 18, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28821973/bilirubin-in-the-early-course-of-venovenous-extracorporeal-membrane-oxygenation-support-for-refractory-ards
#16
Chiara Lazzeri, Manuela Bonizzoli, Giovanni Cianchi, Stefano Batacchi, Marco Chiostri, Giorgio Enzo Fulceri, Laura Tadini Buoninsegni, Adriano Peris
Bilirubin is known as a marker of hepatic dysfunction and is incorporated in scoring algorithms to assess prognosis in critically ill patients. No data are so far available on the prognostic role of hepatic dysfunction in patients with severe ARDS on venovenous extracorporeal membrane oxygenation (VV-ECMO) support. In 112 consecutive patients with severe ARDS treated with VV-ECMO, we aimed at assessing whether increased bilirubin during the first 72 h could affect early death. Increased serum bilirubin (≥1...
August 18, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28821963/myocardial-regenerative-therapy-using-a-scaffold-free-skeletal-muscle-derived-cell-sheet-in-patients-with-dilated-cardiomyopathy-even-under-a-left-ventricular-assist-device-a-safety-and-feasibility-study
#17
Yasushi Yoshikawa, Shigeru Miyagawa, Koichi Toda, Atsuhiro Saito, Yasushi Sakata, Yoshiki Sawa
BACKGROUND AND PURPOSE: Despite promising experimental results, clinically, intramyocardial myoblast injection failed to reverse remodeling and it induced arrhythmogenicity. In contrast, scaffold-free skeletal muscle-derived cell (SC) sheets attenuated cardiac dysfunction and arrhythmogenicity via paracrine effects. We report the first clinical trial of SC sheet implantation (SCSI) conducted in four patients with dilated cardiomyopathy (DCM) supported by a left ventricular assist device (LVAD)...
August 18, 2017: Surgery Today
https://www.readbyqxmd.com/read/28821962/influence-of-aerobic-fitness-on-vasoreactivity-in-young-men
#18
Preston L Bell, Edward T Kelley, Stephanie M McCoy, Daniel P Credeur
Previous work has demonstrated a direct relationship between aerobic fitness and vasodilatory function (i.e., flow-mediated dilation; FMD); however, the relation between aerobic fitness and vasoconstrictor responsiveness (i.e., low flow-mediated constriction; L-FMC), and the overall vasoactive range (FMD + L-FMC) is unclear. PURPOSE: To test the hypothesis that L-FMC and the overall vasoactive range (FMD + L-FMC) will be related to aerobic fitness in young, healthy men. METHODS: Twenty men (age: 23 ± 5 years) were recruited, and divided evenly into a higher (HF) vs...
August 18, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28821937/natural-hazard-susceptibility-assessment-for-road-planning-using-spatial-multi-criteria-analysis
#19
Caroline S J Karlsson, Zahra Kalantari, Ulla Mörtberg, Bo Olofsson, Steve W Lyon
Inadequate infrastructural networks can be detrimental to society if transport between locations becomes hindered or delayed, especially due to natural hazards which are difficult to control. Thus determining natural hazard susceptible areas and incorporating them in the initial planning process, may reduce infrastructural damages in the long run. The objective of this study was to evaluate the usefulness of expert judgments for assessing natural hazard susceptibility through a spatial multi-criteria analysis approach using hydrological, geological, and land use factors...
August 18, 2017: Environmental Management
https://www.readbyqxmd.com/read/28821924/-89-zr-labeled-nivolumab-for-imaging-of-t-cell-infiltration-in-a-humanized-murine-model-of-lung-cancer
#20
Christopher G England, Dawei Jiang, Emily B Ehlerding, Brian T Rekoske, Paul A Ellison, Reinier Hernandez, Todd E Barnhart, Douglas G McNeel, Peng Huang, Weibo Cai
PURPOSE: Nivolumab is a human monoclonal antibody specific for programmed cell death-1 (PD-1), a negative regulator of T-cell activation and response. Acting as an immune checkpoint inhibitor, nivolumab binds to PD-1 expressed on the surface of many immune cells and prevents ligation by its natural ligands. Nivolumab is only effective in a subset of patients, and there is limited evidence supporting its use for diagnostic, monitoring, or stratification purposes. METHODS: (89)Zr-Df-nivolumab was synthesized to map the biodistribution of PD-1-expressing tumor infiltrating T-cells in vivo using a humanized murine model of lung cancer...
August 19, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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