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https://www.readbyqxmd.com/read/29319596/obstructive-sleep-apnea-assessed-by-overnight-polysomnography-in-patients-with-keratoconus
#1
Emilio Pedrotti, Christian Luigi Demasi, Adriano Fasolo, Erika Bonacci, Tommaso Brighenti, Nicola Gennaro, Marcello Ferrari, Giorgio Marchini
PURPOSE: To determine the prevalence of obstructive sleep apnea (OSA) in patients with keratoconus (KCN) and to evaluate the association between the severity of KCN and OSA. METHODS: OSA was diagnosed with an overnight home sleep apnea test. As estimated by home monitoring, an apnea-hypopnea index threshold of ≥5 sleep-related obstructive breathing events per hour was considered suggestive of OSA. For grading KCN severity (Amsler-Krumeich classification), slit-lamp biomicroscopy, corneal topography, and pachymetry measurements were performed...
January 9, 2018: Cornea
https://www.readbyqxmd.com/read/29302633/graphene-coupled-zno-a-robust-nir-induced-catalyst-for-rapid-photo-oxidation-of-cyanide
#2
Gururaj M Neelgund, Aderemi Oki
Herein, we report the modulation of ZnO for enhancement of its ability toward plasmonic absorption of near-infrared (NIR) photons through coupling of graphene (GR). The reported modification led GR-ZnO to be a promising photocatalyst by the complete removal of poisonous and nonvolatile potassium cyanide from water. The photocatalytic degradation of cyanide was revealed by exposing it to NIR laser and comparing with the rate of UV, visible, and sunlight using their apparent reaction rate constants derived from the Langmuir-Hinshelwood model...
December 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29259886/batch-growth-kinetic-studies-of-locally-isolated-cyanide-degrading-serratia-marcescens-strain-aq07
#3
Kabiru Ibrahim Karamba, Siti Aqlima Ahmad, Azham Zulkharnain, Nur Adeela Yasid, Salihu Ibrahim, Mohd Yunus Shukor
The evaluation of degradation and growth kinetics of Serratia marcescens strain AQ07 was carried out using three half-order models at all the initial concentrations of cyanide with the values of regression exceeding 0.97. The presence of varying cyanide concentrations reveals that the growth and degradation of bacteria were affected by the increase in cyanide concentration with a total halt at 700 ppm KCN after 72 h incubation. In this study, specific growth and degradation rates were found to trail the substrate inhibition kinetics...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29251802/stepwise-introduction-of-cyano-groups-into-nido-and-closo-undecaborate-clusters
#4
Szymon Z Konieczka, Florian Schlüter, Christoph Sindorf, Christoph Kerpen, Eduard Bernhardt, Maik Finze
Eleven-vertex closo- and nido-boron clusters with one or two exo-cyano groups have been obtained via a series of consecutive cage-opening and -closure reactions starting from K2[closo-B11H11] (K21). In the first step, K21 reacts with KCN in water at elevated temperatures to yield [7-NC-nido-B11H12]2- (5a). Oxidation of 5a with PbO2 gives [NC-closo-B11H10]2- (2). In analogous, subsequent reactions, dianion 2 is converted with KCN regioselectively into [7,9-(NC)2-nido-B11H11]2- (6a) and is further oxidized to [(NC)2-closo-B11H9]2- (3)...
December 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29173205/effect-of-maternal-dyslipidaemia-on-the-cardiorespiratory-physiology-and-biochemical-parameters-in-male-rat-offspring
#5
Keyth Sulamitta L Guimarães, Emmanuel Veríssimo de Araújo, Jailane Souza Aquino, Danilo Assis Gadelha, Camille Moura Balarini, João Henrique Costa-Silva, Marciane Magnani, Hubert Vidal, Valdir Andrade Braga, José Luiz de Brito Alves
The present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (RF), tidal volume (VT) and ventilation (VE) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0·04 %), were recorded from awake 90-d-old male offspring...
November 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29159542/evaluation-of-the-removal-of-potassium-cyanide-and-its-toxicity-in-green-algae-chlorella-vulgaris
#6
Qingqing Liu, Guangsheng Zhang, Jiannan Ding, Hua Zou, Hongxing Shi, Chaoqun Huang
To evaluate the removal of potassium cyanide (KCN) and its toxicity in algae, an initial comprehensive analysis was performed with Chlorella vulgaris. The algae showed potential removal capability for KCN, with the maximal removal rate of 61%. Moreover, effects of KCN on growth, cellular morphology and antioxidant defense system of C. vulgaris were evaluated. Cell number and chlorophyll a content decreased in most cases, with the maximal inhibition rates of 48% and 99%, respectively. The 100 mg L(- 1) KCN seriously damaged the algal cell membrane...
November 20, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29052684/synthesis-of-an-f-bodipy-2-catenane-using-the-chemistry-of-bis-dipyrrinato-metal-complexes
#7
Bilal Nisanci, Sinem Sahinoglu, Esra Tuner, Mustafa Arik, İbrahim Kani, Arif Dastan, Özgür Altan Bozdemir
ML2 type complexes of an olefin terminated 5H-dipyrrin ligand can be subjected to twofold ring closing metathesis to give bis(dipyrrinato)copper(ii) and bis(dipyrrinato)zinc(ii) [2]catenates. Demetalation of the copper(ii) [2]catenate with KCN/N2H4·H2O gave the corresponding bis(dipyrrin) [2]catenand. The boron difluoride complex of this bis(dipyrrin) was obtained as the first fluorescent F-BODIPY [2]catenane.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29039092/peg-quantitation-using-reversed-phase-high-performance-liquid-chromatography-and-charged-aerosol-detection
#8
Mackensie C Smith, Jeffrey D Clogston
This chapter describes a method for the quantitation of polyethylene glycol (PEG) in PEGylated colloidal gold nanoparticles using a reversed-phase high-performance liquid chromatography (RP-HPLC) with charged aerosol detection. The method can be used to calculate the total PEG on the nanoparticle, as well as the bound and free unbound PEG fractions after a simple centrifugation step. This is a significant distinction as the bound PEG fraction affects biocompatibility, circulation time, and overall nanoparticle efficacy...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28987939/a-hypothalamo-midbrain-medullary-pathway-involved-in-the-inhibition-of-the-respiratory-chemoreflex-response-induced-by-potassium-cyanide-in-rodents
#9
Tabinda Zafar, Charly Brouillard, Laurence Lanfumey, Caroline Sévoz-Couche
Recent studies have demonstrated that a mild stimulation of the dorsomedian nucleus of the hypothalamus (DMH), a defense area, induces the inhibition of the carotid chemoreflex tachypnea. DMH activation reduces the cardiac chemoreflex response via the dorsolateral part of the periaqueductal grey matter (dlPAG) and serotonin receptors (5-HT3 subtype) in the nucleus tractus solitarius (NTS). The objectives of this study were to assess whether dlPAG and subsequent NTS 5-HT3 receptors are involved in chemoreflex tachypnea inhibition during mild activation of the DMH...
October 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28962160/effect-of-eicosapentaenoic-acid-and-pitavastatin-on-electrophysiology-and-anticoagulant-gene-expression-in-mice-with-rapid-atrial-pacing
#10
Maoqing Tong, Jiewen Wang, Yunxin Ji, Xiaomin Chen, Jieru Wang, Shuangshuang Wang, Liemin Ruan, Hanbin Cui, Ying Zhou, Qingyu Zhang, Eiichi Watanabe
Atrial remodeling is considered to be any persistent change in atrial structure or function, and is responsible for the development and perpetuation of atrial fibrillation (AF). Oxidative stress and intracellular pH regulation may also be linked to AF; however it remains unclear whether eicosapentaenoic acid (EPA) or statins have beneficial therapeutic effects. The aim of the present study was to investigate the effects of EPA and pitavastatin on the electrophysiology of and gene expressions in mice with rapidly-paced atria...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28922956/dmts-is-an-effective-treatment-in-both-inhalation-and-injection-models-for-cyanide-poisoning-using-unanesthetized-mice
#11
Susan M DeLeon, Jason D Downey, Diane M Hildenberger, Melissa O Rhoomes, Lamont Booker, Gary A Rockwood, Kelly A Basi
CONTEXT: Cyanide (CN) is a metabolic poison, halting ATP synthesis by inhibiting complex IV of the electron transport chain. If exposed at high enough concentrations, humans and most animals can die within minutes. Because time is a crucial factor in survival of CN poisoning, a rapidly bioavailable, nontoxic, easy to administer CN medical countermeasure could improve morbidity/mortality in a mass CN exposure scenario. The most likely route of exposure to CN is via inhalation. OBJECTIVE: This study examined the efficacy of a new formulation for dimethyl trisulfide (DMTS), a countermeasure which has shown promise as a treatment for CN poisoning, using both inhalation and injection models of CN exposure...
September 19, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28780857/barcode-dna-mediated-signal-amplifying-strategy-for-ultrasensitive-biomolecular-detection-on-matrix-assisted-laser-desorption-ionization-time-of-flight-maldi-tof-mass-spectrometry
#12
Raheel Ahmad, Hyowon Jang, Bhagwan S Batule, Hyun Gyu Park
We have devised a barcode DNA-mediated signal amplifying strategy for ultrasensitive biomolecular detection by utilizing matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). As a model target, thrombin was first captured by specific aptamer15 functionalized on magnetic beads (MBs-apt15) and sandwiched through the simultaneous interaction with gold nanoparticles modified with another specific aptamer29 and barcode DNA molecules (apt29-AuNPs-bcDNAs). The sandwiched complex was collected by convenient magnetic separation and then treated with potassium cyanide (KCN) to dissolve the gold nanoparticles (AuNPs) and consequently release the barcode DNA molecules (bcDNAs), which were then again magnetically separated and analyzed by using MALDI-TOF MS...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28754902/effect-of-sodium-treatment-on-the-performance-of-electrostatic-spray-assisted-vapour-deposited-copper-poor-cu-in-ga-s-se-2-solar-cells
#13
Mingqing Wang, Md Anower Hossain, Kwang-Leong Choy
In our work, eco-friendly, non-vacuum and low cost Electrostatic Spray Assisted Vapour Deposition (ESAVD) method has been used to produce Cu(In,Ga)(S,Se)2 (CIGS) solar cells. Copper (Cu) deficient (Cu/In + Ga = 0.76) CIGS films were designed to avoid the rather dangerous KCN treatment step for the removal of conductive minor phases of Cu2S/Cu2Se. A simple sodium (Na) treatment method was used to modify the morphology and electronic properties of the absorber and it clearly improved the solar cell performance...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28749896/elimination-of-anterior-corneal-steepening-with-descemet-membrane-endothelial-keratoplasty-in-a-patient-with-fuchs-dystrophy-and-keratoconus-implications-for-iol-calculation
#14
Reena Gupta, Ruta Kinderyte, Deborah S Jacobs, Ula V Jurkunas
PURPOSE: To report a case of coexistent Fuchs endothelial corneal dystrophy (FECD) and keratoconus (KCN) in which there was normalization of corneal topography after Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective medical record review. RESULTS: Preoperative findings revealed a best-corrected visual acuity of 20/40 with -1.00 - 2.50 × 147, topographic maximum keratometry of 50.8 D with inferior steeping, and confluent guttae in the left eye...
October 2017: Cornea
https://www.readbyqxmd.com/read/28735400/zymographic-method-for-distinguishing-different-classes-of-superoxide-dismutases-in-plants
#15
Ashwini R Jamdhade, Ramanjulu Sunkar, Vandana K Hivrale
In plants, especially in chloroplasts, superoxide radical is generated when an electron is transferred to dimolecular O2 due to decreased activity of Photosystem I. The superoxide (O2(-)) radical accumulation is more rampant in plants exposed to abiotic stresses due to oxidation of photosystem components. Excessive superoxide radical accumulation will lead to oxidative damage to the cellular macromolecules. The ubiquitous superoxide dismutases (SODs) represent critical enzymatic antioxidant system present in cells, which can catalyze the disproportion of superoxide (O2(-)) radical rapidly into hydrogen peroxide (H2O2) and molecular oxygen...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28711978/the-activity-of-the-antioxidant-defense-system-of-the-weed-species-senna-obtusifolia-l-and-its-resistance-to-allelochemical-stress
#16
Érica Marusa Pergo Coelho, Mauro Cezar Barbosa, Márcio Shigueaki Mito, Gislaine Cristiane Mantovanelli, Rubem Silvério Oliveira, Emy Luiza Ishii-Iwamoto
Senna obtusifolia L., a common weed in the tropical and subtropical regions of the world, is able to germinate under adverse environmental conditions, suggesting that this species has efficient stress-adaptation strategies. The aims of the present work were to examine the energy metabolism and the antioxidant defense system of the Senna obtusifolia L. during seed germination and initial growth, and the responses to allelochemical-induced stress. Respiratory activity, the activities of alcohol dehydrogenase (ADH), superoxide dismutase (SOD), catalase (CAT),guaicol peroxidase (POD), ascorbate peroxidase (APX), glutathione reductase (GR), lipoxygenase (LOX) and the content of malondialdehyde (MDA) and glutathione (GSSG and GSH) were measured...
July 15, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28688894/a-review-of-keratoconus-diagnosis-pathophysiology-and-genetics
#17
REVIEW
Veronica Mas Tur, Cheryl MacGregor, Rakesh Jayaswal, David O'Brart, Nicholas Maycock
We discuss new approaches to the early detection of keratoconus and recent investigations regarding the nature of its pathophysiology. We review the current evidence for its complex genetics and evaluate the presently identified genes/loci and potential candidate gene/loci. In addition, we highlight current research methodologies that may be used to further elucidate the pathogenesis of keratoconus.
November 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28634393/a-small-molecule-ds44170716-inhibits-ca-2-induced-mitochondrial-permeability-transition
#18
Naohiro Kon, Atsushi Satoh, Naoki Miyoshi
Mitochondria are involved in a variety of physiological and pathological processes. Ca(2+) uptake is one of the important functions of the organelle for maintenance of cellular Ca(2+) homeostasis. In pathological conditions such as ischemia reperfusion injury, Ca(2+) overload into mitochondria induces mitochondrial permeability transition (MPT), a critical step for cell death. Because inhibition of MPT is a promising approach to protecting cells and organs, it is important for drug discovery to identify novel chemicals or mechanisms to inhibit MPT...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623432/identification-and-expression-analysis-of-cys-a1-cys-c1-nit4-genes-in-rice-seedlings-exposed-to-cyanide
#19
Xiao-Zhang Yu, Yu-Juan Lin, Chun-Jiao Lu, Xue-Hong Zhang
Involvement of genes (CYS-A1, CYS-C1 and NIT4) encoded with cysteine synthase, β-cyanoalanine synthase, nitrilase and cyanide metabolisms are evident in Arabidopsis. In the present study, identifications of CYS-A1, CYS-C1 and NIT4, predictions of conserved motifs, and constructions of phylogenetic relationships, based on their amino acid sequences in rice, were conducted. In order to elucidate the transcriptional responses of these cyanide-degrading genes, two candidate homologues were selected for each gene to test their expression changes upon exposure to exogenous KCN in rice seedlings using RT-PCR...
June 16, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28552364/rna-seq-analysis-of-the-role-of-calcium-chloride-stress-and-electron-transport-in-mitochondria-for-malachite-green-decolorization-by-aspergillus-niger
#20
Ola M Gomaa, Nabila S Selim, Josephine Wee, John E Linz
Aspergillus niger was previously demonstrated to decolorize the commercial dye malachite green (MG) and this process was enhanced under calcium chloride (CaCl2) treatment. Previous data also suggested that the decolorization process is related to mitochondrial cytochrome c. In the current work, we analyzed in depth the specific relationship between CaCl2 treatment and MG decolorization. Gene expression analysis (RNA Seq) using Next Generation Sequencing (NGS) revealed up-regulation of 28 genes that are directly or indirectly associated with stress response functions as early as 30min of CaCl2 treatment; these data further strengthen our previous findings that CaCl2 treatment induces a stress response in A...
May 24, 2017: Fungal Genetics and Biology: FG & B
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