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https://www.readbyqxmd.com/read/28328983/novel-keyword-co-occurrence-network-based-methods-to-foster-systematic-reviews-of-scientific-literature
#1
Srinivasan Radhakrishnan, Serkan Erbis, Jacqueline A Isaacs, Sagar Kamarthi
Systematic reviews of scientific literature are important for mapping the existing state of research and highlighting further growth channels in a field of study, but systematic reviews are inherently tedious, time consuming, and manual in nature. In recent years, keyword co-occurrence networks (KCNs) are exploited for knowledge mapping. In a KCN, each keyword is represented as a node and each co-occurrence of a pair of words is represented as a link. The number of times that a pair of words co-occurs in multiple articles constitutes the weight of the link connecting the pair...
2017: PloS One
https://www.readbyqxmd.com/read/28318118/distinct-expression-of-nk2-homeobox-1-nkx2-1-and-goblet-cell-hyperplasia-in-nasal-polyps-with-different-endotypes
#2
Jintao Du, Luo Ba, Bo Li, Feng Liu, Xianting Hu, Jie Zhang, Yafeng Liu, Junming Xian, Sixi Liu, Huabin Li
BACKGROUND: Decreased expression of airway epithelial-specific transcription factor NK2 homeobox 1 (NKX2-1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2-1 in nasal polyps (NPs) with different endotypes were undefined yet. METHODS: We examined the expression of key cytokines (interleukin [IL]-4 IL-5, IL-13, and IL-17A, etc.) and NKX2-1 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA), and Western blot analysis...
March 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28299936/development-of-decarboxylative-cyanation-reactions-for-c-13-c-14-carboxylic-acid-labeling-using-an-electrophilic-cyanating-reagent
#3
Fengbin Song, Rhys Salter, Lu Chen
Degradation-reconstruction approaches for isotope labeling synthesis have been known for their remarkable efficiency, but applications are scarce due to some fundamental limitations of the chemistries developed to date. The decarboxylative cyanation reaction, as a degradation-reconstruction approach, is especially useful in rapid carboxylic acid carbon isotope labeling, however development toward its application as a widespread technique has stalled at the early stages due to numerous limitations which include somewhat narrow applicability...
March 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28286097/effect-of-the-periodic-properties-of-toxic-stress-on-the-oscillatory-behaviour-of-glycolysis-in-yeast-evidence-of-a-toxic-effect-frequency
#4
C André, F Gagné
Starving and nondividing yeast cells induce changes in the electron donor nicotinamide adenine dinucleotide (NADH) levels in a cyclic and wave-like manner for over 90min. Yeast suspensions were used to examine the toxic effects of contaminants on the cyclic behaviour of metabolite changes during anaerobic glycolysis. The cyclic behaviour NADH levels in yeast cell suspensions starved for 2 to 5h was studied after the addition of 10mM glucose for 5min followed by 10mM KCN to block aerobic glycolysis. The effects of three toxic elements (CuSO4, silver nanoparticles-nAg, and GdCl3), known for their potential to alter glycolsysis, on NADH levels over time were examined during the 3-h starvation step...
March 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28279900/electrochemical-oxidation-of-cyanide-on-3d-ti-ruo2-anode-using-a-filter-press-electrolyzer
#5
Tzayam Pérez, Rosa L López, José L Nava, Isabel Lázaro, Guillermo Velasco, Roel Cruz, Israel Rodríguez
The novelty of this communication lies in the use of a Ti-RuO2 anode which has not been tested for the oxidation of free cyanide in alkaline media at concentrations similar to those found in wastewater from the Merrill Crowe process (100 mg L(-1) KCN and pH 11), which is typically used for the recovery of gold and silver. The anode was prepared by the Pechini method and characterized by SEM. Linear sweep voltammetries on a Ti-RuO2 rotating disk electrode (RDE) confirmed that cyanide is oxidized at 0.45 < E < 1...
February 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28235872/role-and-characterization-of-a-cyanide-induced-3-cyanoalanine-nitrilase-in-the-cyanide-assimilating-bacterium-pseudomonas-pseudoalcaligenes-cect-5344
#6
Felipe Acera, María Isabel Carmona, Francisco Castillo, Alberto Quesada, Rafael Blasco
Pseudomonas pseudoalcaligenes CECT 5344 is a bacterium able to assimilate cyanide as the sole nitrogen source. Under this growth conditions, a 3-cyanoalanine nitrilase enzymatic activity was induced. This activity was coded by nit4, one of the four nitrilases detected in the genome of this bacterium, and its expression in E. coli enabled the recombinant strain to fully assimilate 3-cyanoalanine. P. pseudoalcaligenes CECT 5344 showed a weak growth level with 3-cyanoalanine as N-source, unless KCN was also added...
February 24, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28223243/on-the-verge-of-a-respiratory-type-panic-attack-selective-activations-of-rostrolateral-and-caudoventrolateral-periaqueductal-gray-matter-following-short-lasting-escape-to-a-low-dose-of-potassium-cyanide
#7
Cláudia Janaina Torres Müller, Jeyce Willig Quintino-Dos-Santos, Fagna Giacomin Schimitel, Sérgio Tufik, Vanessa Beijamini, Newton Sabino Canteras, Luiz Carlos Schenberg
Intravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO2, it is suppressed by both lesions of PAG and clinically effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxia-sensitive alarm system the activation of which could both precipitate panic and render the subject hypersensitive to CO2. Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (>60µg) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior...
February 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/28218895/ferroelectric-glass-of-spheroidal-dipoles-with-impurities-polar-nanoregions-response-to-applied-electric-field-and-ergodicity-breakdown
#8
Kyohei Takae, Akira Onuki
Using molecular dynamics simulation, we study dipolar glass in crystals composed of slightly spheroidal, polar particles and spherical, apolar impurities between metal walls. We present physical pictures of ferroelectric glass, which have been observed in relaxors, mixed crystals (such as KCN x KBr1-x ), and polymers. Our systems undergo a diffuse transition in a wide temperature range, where we visualize polar nanoregions (PNRs) surrounded by impurities. In our simulation, the impurities form clusters and their space distribution is heterogeneous...
April 26, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28188852/the-k%C3%A3-lliker-fuse-nucleus-acts-as-a-timekeeper-for-late-expiratory-abdominal-activity
#9
Sarah E M Jenkin, William K Milsom, Daniel B Zoccal
While the transition from the inspiratory to the post-inspiratory (post-I) phase is dependent on the pons, little attention has been paid to understanding the role of the pontine respiratory nuclei, specifically the Kölliker-Fuse nucleus (KF), in transitioning from post-I to the late expiratory (late-E) activity seen with elevated respiratory drive. To elucidate this, we used the in situ working heart-brainstem preparation of juvenile male Holtzman rats and recorded from the vagus (cVN), phrenic (PN) and abdominal nerves (AbN) during baseline conditions and during chemoreflex activation [with potassium cyanide (KCN; n=13) or hypercapnia (8% CO2; n=10)] to recruit active expiration...
February 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/28106742/mechanochemical-lignin-mediated-strecker-reaction
#10
Saumya Dabral, Mathias Turberg, Andrea Wanninger, Carsten Bolm, José G Hernández
A mechanochemical Strecker reaction involving a wide range of aldehydes (aromatic, heteroaromatic and aliphatic), amines, and KCN afforded a library of α-aminonitriles upon mechanical activation. This multicomponent process was efficiently activated by lignocellulosic biomass as additives. Particularly, commercially available Kraft lignin was found to be the best activator for the addition of cyanide to the in situ formed imines. A comparative study of the (31)P-NMR (Nuclear Magnetic Resonance) along with IR (Infrared) data analysis for the Kraft lignin and methylated Kraft lignin samples ascertained the importance of the free hydroxyl groups in the activation of the mechanochemical reaction...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28075127/homeomorphic-isomerization-as-a-design-element-in-container-molecules-binding-displacement-and-selective-transport-of-mcl2-species-m-pt-pd-ni
#11
Sugam Kharel, Hemant Joshi, Stephen Bierschenk, Michael Stollenz, Deeb Taher, Nattamai Bhuvanesh, John A Gladysz
The dibridgehead diphosphine ((CH2)14)3 P (1) can rapidly turn inside-out (homeomorphic isomerization) to give a mixture of in,in and out,out isomers. The exo directed lone pairs in the latter are able to scavenge Lewis acidic MCl2; cagelike adducts of the in,in isomer, trans- Cl2(P((CH2)14)3 P) (M = 2/Pt, 3/Pd, 4/Ni), then form. The NiCl2 unit in 4 may be replaced by PtCl2 or PdCl2, but 2 and 3 do not give similar substitutions. U-tubes are charged with CH2Cl2 solutions of 1 (lower phase), an aqueous solution of K2MCl4 (charging arm; M = Pt, Pd), and an aqueous solution of excess KCl (receiving arm)...
January 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28060057/trends-in-corneal-transplantation-in-keratoconus
#12
Daniel Sarezky, Stephen E Orlin, Wei Pan, Brian L VanderBeek
PURPOSE: To determine recent trends in and sociodemographic/comorbid conditions associated with penetrating keratoplasty (PK) and lamellar keratoplasty (LK) for keratoconus (KCN). METHODS: Patients with KCN and subsequent PK and LK procedures were identified using International Classification of Diseases, 9th revision (ICD-9) and Current Procedural Terminology (CPT) billing codes. The change in surgical rates was calculated over a decade, and multivariate analysis demonstrated factors associated with undergoing surgery...
2017: Cornea
https://www.readbyqxmd.com/read/28057642/accelerated-transepithelial-corneal-cross-linking-for-progressive-keratoconus-a-prospective-study-of-12%C3%A2-months
#13
Wei Aixinjueluo, Tomohiko Usui, Takashi Miyai, Tetsuya Toyono, Toshihiro Sakisaka, Satoru Yamagami
BACKGROUND/AIMS: To evaluate the clinical results of accelerated transepithelial corneal cross-linking (CXL) in Japanese patients with progressive keratoconus (KCN). METHODS: Thirty eyes of 19 patients (16 male, 3 female patients) with progressive KCN were included. The mean age was 24.9±7.0 (range 16-38) years. All patients received ultraviolet A radiation for 3 min at an irradiance of 30 mW/cm(2). Patients were followed up on the first day, at 1 week and 2 weeks, and at 1 month, 3 months, 6 months and 12 months postoperatively...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28042810/perturbation-analysis-of-calcium-alkalinity-and-secretion-during-growth-of-lily-pollen-tubes
#14
Lawrence J Winship, Caleb Rounds, Peter K Hepler
Pollen tubes grow by spatially and temporally regulated expansion of new material secreted into the cell wall at the tip of the tube. A complex web of interactions among cellular components, ions and small molecule provides dynamic control of localized expansion and secretion. Cross-correlation studies on oscillating lily (Lilium formosanum Wallace) pollen tubes showed that an increase in intracellular calcium follows an increase in growth, whereas the increase in the alkaline band and in secretion both anticipate the increase in growth rate...
December 30, 2016: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27917154/hydrogen-cyanide-in-the-rhizosphere-not-suppressing-plant-pathogens-but-rather-regulating-availability-of-phosphate
#15
Tomaž Rijavec, Aleš Lapanje
Plant growth promoting rhizobacteria produce chemical compounds with different benefits for the plant. Among them, HCN is recognized as a biocontrol agent, based on its ascribed toxicity against plant pathogens. Based on several past studies questioning the validity of this hypothesis, we have re-addressed the issue by designing a new set of in vitro experiments, to test if HCN-producing rhizobacteria could inhibit the growth of phytopathogens. The level of HCN produced by the rhizobacteria in vitro does not correlate with the observed biocontrol effects, thus disproving the biocontrol hypothesis...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27861304/trends-in-corneal-transplantation-in-keratoconus
#16
Daniel Sarezky, Stephen E Orlin, Wei Pan, Brian L VanderBeek
PURPOSE: To determine recent trends in and sociodemographic/comorbid conditions associated with penetrating keratoplasty (PK) and lamellar keratoplasty (LK) for keratoconus (KCN). METHODS: Patients with KCN and subsequent PK and LK procedures were identified using International Classification of Diseases, 9th revision (ICD-9) and Current Procedural Terminology (CPT) billing codes. The change in surgical rates was calculated over a decade, and multivariate analysis demonstrated factors associated with undergoing surgery...
November 16, 2016: Cornea
https://www.readbyqxmd.com/read/27763697/changes-in-cardiovascular-responses-to-chemoreflex-activation-of-rats-recovered-from-protein-restriction-are-not-related-to-at1-receptors
#17
Renato Willian Martins Sá, Andrea Siqueira Haibara, Paula Magalhães Gomes, Giovana Lopes Aguiar, Rafael Souza Leopoldino Nascimento, Maria Lucia Pedrosa, Andréia Carvalho Alzamora, Lisandra Brandino de Oliveira, Leonardo Máximo Cardoso
What is the central question of this study? In this study, we sought to investigate whether cardiovascular responses to peripheral chemoreflex activation of rats recovered from protein restriction are related to activation of AT1 receptors. What is the main finding and its importance? This study highlights the fact that angiotensinergic mechanisms activated by AT1 receptors do not support increased responses to peripheral chemoreflex activation by KCN in rats recovered from protein restriction. Also, we found that protein restriction led to increased resting ventilation in adult rats, even after recovery...
January 1, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/27737792/effects-of-alprazolam-and-cannabinoid-related-compounds-in-an-animal-model-of-panic-attack
#18
Luara A Batista, Andrea S Haibara, Luiz C Schenberg, Fabricio A Moreira
Selective stimulation of carotid chemoreceptors by intravenous infusion of low doses of potassium cyanide (KCN) produces short-lasting escape responses that have been proposed as a model of panic attack. In turn, preclinical studies suggest that facilitation of the endocannabinoid system attenuate panic-like responses. Here, we compared the effects of cannabinoid-related compounds to those of alprazolam, a clinically effective panicolytic, on the duration of the escape reaction induced by intravenous infusion of KCN (80μg) in rats...
October 11, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27666790/development-and-dynamic-regulation-of-mitochondrial-network-in-human-midbrain-dopaminergic-neurons-differentiated-from-ipscs
#19
Du Fang, Yu Qing, Shijun Yan, Doris Chen, Shirley ShiDu Yan
Mitochondria are critical to neurogenesis, but the mechanisms of mitochondria in neurogenesis have not been well explored. We fully characterized mitochondrial alterations and function in relation to the development of human induced pluripotent stem cell (hiPSC)-derived dopaminergic (DA) neurons. Following directed differentiation of hiPSCs to DA neurons, mitochondria in these neurons exhibit pronounced changes during differentiation, including mature neurophysiology characterization and functional synaptic network formation...
October 11, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27640005/very-low-prevalence-of-keratoconus-in-a-large-series-of-vernal-keratoconjunctivitis-patients
#20
Roberto Caputo, Francesco Versaci, Neri Pucci, Cinzia de Libero, Gioia Danti, Salvatore De Masi, Rita Mencucci, Elio Novembre, Bennie H Jeng
PURPOSE: To evaluate the prevalence of keratoconus (KC) and other corneal abnormalities by means of videokeratography and tomography in a large series of patients affected by vernal keratoconjunctivitis (VKC). DESIGN: Cross-sectional study. METHODS: • Setting: Single-center, children's hospital. • Study Population: 651 consecutive patients with VKC and a control group of 500 were prospectively recruited between May 2012 and September 2013, with a minimum follow-up of 12 months...
September 14, 2016: American Journal of Ophthalmology
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