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Organ donor management

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https://www.readbyqxmd.com/read/29661419/challenges-of-organ-donation-potential-donors-for-transplantation-in-an-area-of-brazil-s-northeast
#1
B B O Marinho, A T F Santos, A S Figueredo, L S A B Cortez, M C A Viana, G M Santos, J W S Brito, V C F Rebouças, P Braga-Neto
BACKGROUND: New strategies to manage the pool of potential donors are needed to increase organ donation rates. The purpose of the study was to identify the main causes of lack of organ donation and to identify the sociodemographic and clinical profiles of potential organ donors in an area of northeastern Brazil. METHODS: We conducted a cross-sectional, retrospective, observational study between November 2015 and January 2017. RESULTS: A total of 150 potential donors were included in the sample...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29656530/mycobacterium-tuberculosis-after-solid-organ-transplantation-a-review-of-more-than-2000-cases
#2
Cybele Lara R Abad, Raymund R Razonable
BACKGROUND: Mycobacterium tuberculosis (TB) is a common pathogen worldwide, and it may cause significant infection after solid organ transplantation (SOT). We reviewed all reported TB cases to provide an update on its epidemiology, clinical presentation, management and outcome after SOT. METHODS: MEDLINE, EMBASE, and OVID were reviewed from January 1, 1998 to Dec 31, 2016 using key words tuberculosis and solid organ transplant or transplantation. RESULTS: There were 187 publications reporting 2082 cases of TB among kidney (n=1719), liver (n=253), heart (n=77), lung (n=25), and kidney-pancreas (n=8) recipients...
April 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29653206/late-effects-screening-guidelines-after-hematopoietic-cell-transplantation-hct-for-hemoglobinopathy-consensus-statement-from-the-second-pediatric-blood-and-marrow-transplant-consortium-international-conference-on-late-effects-after-pediatric-hct
#3
Shalini Shenoy, Javid Gaziev, Emanuele Angelucci, Allison King, Monica Bhatia, Angela Smith, Dorine Bresters, Anne E Haight, Christine N Duncan, Josu de la Fuente, Andrew C Dietz, K Scott Baker, Michael A Pulsipher, Mark C Walters
Allogeneic hematopoietic cell transplantation (HCT) can halt organ damage and eliminate symptoms in hemoglobin disorders, including sickle cell disease (SCD) and thalassemia major (TM). Managing the residual manifestations of pre-HCT disease complications and the long-term effects of HCT requires systematic monitoring, follow-up, and intervention when indicated. Late complications vary with age and disease status at HCT, and with transplant variables such as preparative regimen, donor source and compatibility, and immune reconstitution...
April 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29623268/the-new-era-of-transplant-oncology-liver-transplantation-for-nonresectable-colorectal-cancer-liver-metastases
#4
REVIEW
Andre Gorgen, Hala Muaddi, Wei Zhang, Ian McGilvray, Steven Gallinger, Gonzalo Sapisochin
Colorectal cancer (CRC) is the third most incident cancer worldwide. Most of CRC patients will develop distant metastases, mainly to the liver, and liver resection is the only potential chance for cure. On the other hand, only a small proportion of patients with hepatic CRC metastasis are candidates for upfront liver resection. Liver transplantation (LT) is an attractive option for patients with nonresectable CRC liver metastases (NRCLM) without extrahepatic involvement. Initial experiences with LT for NRCLM achieved very poor outcomes, with a 5-year overall survival (OS) lower than 20%...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29622763/esophageal-mucosal-calcinosis-a-rare-site-of-gastrointestinal-mucosal-calcinosis
#5
Aaron R Huber, Brandon S Sprung, John Miller, Jennifer J Findeis-Hosey
BACKGROUND Gastrointestinal tract mucosal calcinosis (MC) tends to affect the gastric mucosa, while esophageal involvement is rare. Gastric MC may be seen with solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure. While the incidence of gastric MC in renal transplant patients undergoing gastric biopsy is common (between 15-29%), to our knowledge esophageal MC has only been previously reported 3 times. CASE REPORT A 68-year-old male dialysis-dependent end stage renal disease status-post deceased donor kidney transplant underwent an esophagogastroduodenoscopy (EGD) for dysphagia and diffuse esophageal wall thickening seen on imaging studies...
April 6, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29618862/acetic-acid-dressings-finding-the-holy-grail-for-infected-wound-management
#6
Kapil S Agrawal, Anup Vidyadhar Sarda, Raghav Shrotriya, Manoj Bachhav, Vinita Puri, Gita Nataraj
Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. In this study, we have evaluated the use of acetic acid for topical application in the treatment of infected wounds...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29602865/family-planning-in-the-democratic-republic-of-the-congo-encouraging-momentum-formidable-challenges
#7
REVIEW
Dieudonné Kwete, Arsene Binanga, Thibaut Mukaba, Théophile Nemuandjare, Muanda Fidele Mbadu, Marie-Thérèse Kyungu, Perri Sutton, Jane T Bertrand
Momentum for family planning in the Democratic Republic of the Congo (DRC) is evident in multiple ways: strong political will, increasing donor support, a growing number of implementing organizations, innovative family planning programming, and a cohesive family planning stakeholder group. Between 2013 and 2017, the modern contraceptive prevalence rate (mCPR) in the capital city of Kinshasa increased from 18.5% to 26.7% among married women, but as of 2013-14, it was only 7.8% at the national level. The National Multisectoral Strategic Plan for Family Planning: 2014-2020 calls for achieving an mCPR of 19...
March 21, 2018: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29589971/clinical-considerations-in-the-hematopoietic-stem-cell-transplant-management-of-primary-immunodeficiencies
#8
Alexandra Laberko, Andrew R Gennery
Primary immunodeficiencies (PID) are genetic immune disorders causing increased predisposition to infections and autoimmunity. The only curative procedure is hematopoietic stem cell transplantation (HSCT), results from which have improved dramatically since 2000. Complications remain a serious issue, especially in HLA non-identical transplantation. In PID patients, persistent infection and autoimmunity with end-organ damage cause particular problems with approach to transplantation. This article examines these, emphasising approach to management and consequences...
April 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29587521/orthotopic-heart-transplantation-in-children
#9
Nagarajan Muthialu
Heart transplantation is a relatively infrequent but technically demanding procedure in pediatric cardiac surgery. Orthotopic heart transplantation is often offered to older children or adolescents following multiple previous operations, but with advances in intensive care, diagnostics, and management, more infants with complex congenital heart diseases are being listed for transplantation. Primary cardiomyopathies remain the most common indication. Outcomes following cardiothoracic transplantation have improved steadily in recent times...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29584911/organ-recovery-cost-assessment-in-the-french-healthcare-system-from-2007-to-2014
#10
Abdelbaste Hrifach, Christell Ganne, Sandrine Couray-Targe, Coralie Brault, Pascale Guerre, Hassan Serrier, Pierre Farge, Cyrille Colin
Background: Organ recovery costs should be assessed to allow efficient and sustainable integration of these costs into national healthcare budgets and policies. These costs are of considerable interest to health economists, hospitals, financial managers and policy makers in most developed countries. This study assessed organ recovery costs from 2007 to 2014 in the French healthcare system based on the national hospital discharge database and a national cost study. The secondary objective was to describe the variability in the population of deceased organ donors during this period...
March 23, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29580785/donor-mesenchymal-stem-cell-linetics-after-transamniotic-stem-cell-therapy-trascet-for-experimental-spina-bifida
#11
Hester F Shieh, Azra Ahmed, Lucas Rohrer, David Zurakowski, Dario O Fauza
PURPOSE: We sought to examine donor mesenchymal stem cell (MSC) kinetics after transamniotic stem cell therapy (TRASCET) in experimental spina bifida. METHODS: Pregnant Sprague-Dawley dams exposed to retinoic acid for the induction of fetal neural tube defects received volume-matched intra-amniotic injections on gestational day 17 (E17; term=E22): either amniotic fluid MSCs (afMSCs) labeled with a luciferase reporter gene (n=78), or luciferase protein alone (n=66)...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29579875/donors-older-than-75-years-do-not-influence-the-appearance-of-biliary-complications-after-liver-transplantation
#12
M R González-Sánchez, P A Cascales-Campos, J J López-Espín, B Febrero, J A Pons, A Vargas Acosta, J Ros, F Sánchez-Bueno, R Robles, L Sáenz, P Ramírez, P Parilla
BACKGROUND: In recent years, several studies have shown that the age of the donor may be related to an increase in the occurrence of biliary complications (BCs), which remain the main cause of morbidity after liver transplantation. This study analyzed the type and management of these BCs, the impact of BCs on graft and patient survival rates, and the influence of some characteristics of donors and recipients on BC appearance in patients transplanted with donors 75 years of age or older...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29579865/analysis-of-the-predictive-ability-for-graft-loss-and-mortality-of-two-criteria-for-early-allograft-dysfunction-after-liver-transplantation
#13
E Brea-Gómez, R Villar-Quintana, C Plata-Illescas, N Zambudio-Carroll, M A Lopez-Garrido, F Nogueras-Lopez, K Muffak-Granero, A Becerra-Massare, M T Villegas-Herrera, I Segura Jiménez, N Muñoz Pérez, J M Villar-Del-Moral
INTRODUCTION: The current imbalance between available donors and potential recipients for orthotopic liver transplantation (OLT) has led to a liberalization of organ acceptance criteria, increasing the risk of post-transplant complications such as early allograft dysfunction (EAD). Consequently, we need accurate criteria to detect patients with early poor graft function to guide the strategies of management. We evaluated the usefulness of two frequently used criteria: the definition from Olthoff et al and the Model for Early Allograft Function (MEAF) scoring...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29559375/contemporary-outcomes-of-ecmo-used-as-bridge-to-lung-transplantation
#14
Ali H Hakim, Usman Ahmad, Kenneth R McCurry, Douglas R Johnston, Gosta B Pettersson, Marie Budev, Sudish Murthy, Eugene H Blackstone, Michael Z Tong
BACKGROUND: Extracorporeal membrane oxygenation (ECMO), when used as bridge to lung transplantation (BTT) identifies high-risk candidates. Recent advances in cannula design and patient selection fosters "awake ambulatory ECMO" as a viable option for critically ill candidates in an attempt to retard deconditioning while awaiting allografts. METHODS: From 2012 to 2015, 30 patients underwent ECMO as BTT. Candidacy for ECMO was determined prior to listing for transplant...
March 17, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29547626/clinical-management-and-outcomes-of-patients-with-hermansky-pudlak-syndrome-pulmonary-fibrosis-evaluated-for-lung-transplantation
#15
Souheil El-Chemaly, Kevin J O'Brien, Steven D Nathan, Gerald L Weinhouse, Hilary J Goldberg, Jean M Connors, Ye Cui, Todd L Astor, Philip C Camp, Ivan O Rosas, Merte Lemma, Vladislav Speransky, Melissa A Merideth, William A Gahl, Bernadette R Gochuico
Pulmonary fibrosis is a progressive, fatal manifestation of Hermansky-Pudlak syndrome (HPS). Some patients with advanced HPS pulmonary fibrosis undergo lung transplantation despite their disease-associated bleeding tendency; others die while awaiting donor organs. The objective of this study is to determine the clinical management and outcomes of a cohort with advanced HPS pulmonary fibrosis who were evaluated for lung transplantation. Six patients with HPS-1 pulmonary fibrosis were evaluated at the National Institutes of Health Clinical Center and one of two regional lung transplant centers...
2018: PloS One
https://www.readbyqxmd.com/read/29543344/graft-versus-host-disease-after-multivisceral-transplantation-a-uk-center-experience-and-update-on-management
#16
Lisa M Sharkey, Sarah Peacock, Neil K Russell, Stephen J Middleton, Andrew J Butler
Graft versus host disease (GVHD) following transplantation of an intestine-containing graft occurs more frequently than with other solid organ transplants and is known to have a poor outcome. The presentation differs from other solid organ transplants, as the gastrointestinal tract is not involved following intestinal transplant. Diagnosis is based on clinical symptoms arising due to native tissue damage and the detection of donor T lymphocytes in circulating blood (T cell chimerism). The ideal treatment strategy has not been defined, with advocates for both increased or decreased immunosuppression...
March 15, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29542121/report-of-a-workshop-on-ensuring-sustainable-access-to-safe-blood-in-developing-countries-international-blood-safety-forum-march-24-2017
#17
REVIEW
Louis M Katz, John J Donnelly, Christopher J Gresens, Jerry A Holmberg, James MacPherson, Peter J K Zacharias, Jean Stanley, Christine Bales
On March 24, 2017, more than 90 experts in blood safety and international development from blood centers, industry, government, and international and nongovernmental organizations gathered in Arlington, Virginia, for the Third International Blood Safety Forum, cosponsored by America's Blood Centers and Global Healing. This report summarizes presentations and major conclusions. The meeting explored ways to increase access to affordable, safe blood for low- and lower-middle-income countries (LMICs) in an era when funding from the US President's Emergency Plan for AIDS Relief (PEPFAR) and the Global Fund has been redirected from preventing the spread of human immunodeficiency virus (HIV) to diagnosing and treating the 25 million-plus people living with HIV in LMICs...
March 14, 2018: Transfusion
https://www.readbyqxmd.com/read/29536565/chronic-cutaneous-graft-versus-host-disease-in-children-a-report-of-14-patients-from-a-tertiary-care-pediatric-dermatology-clinic
#18
Arti Nanda, Maitham A A Husain, Waleed Al-Herz, Adla Almekaimi, Humoud Al-Sabah, Mohammad Al-Otaibi
BACKGROUND/OBJECTIVES: Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment option for many life-threatening disorders in children. Chronic graft-versus-host disease (cGVHD) is a significant complication of HSCT, and its treatment is challenging. Skin is the most common organ affected in cGVHD, with protean manifestations posing a challenge in diagnosis and management. The objective was to have a better understanding of the spectrum of chronic cutaneous GVHD (cc-GVHD) in children...
March 14, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29528966/in-case-you-missed-it-basic-science-advances-in-transplantation-2017
#19
Carla C Baan
Developments in organ preservation techniques, novel immunosuppressants and improved diagnostics have made organ transplantation the success it is today. That does not mean that we are not still striving to perfect techniques, or that there are no more problems to solve. New strategies to address the donor organ shortage, prevent and manage antibody-mediated rejection, lower long-term allograft failure rates and reduce the toxicity of life-long immunosuppressive medication are urgently needed, and are being widely researched...
March 9, 2018: Transplantation
https://www.readbyqxmd.com/read/29528013/early-postoperative-infections-after-liver-transplant
#20
Ebru H Ayvazoglu Soy, Aydincan Akdur, Sedat Yildirim, Hande Arslan, Mehmet Haberal
OBJECTIVES: Despite surgical advances and effective prophylactic strategies in liver transplant, infection is still a major cause of morbidity and mortality. Up to 80% of liver recipients will develop at least 1 infection during the first year after liver transplant. The spectrum and manifestations of these infections are broad and variable. Their diagnosis and treatment are often delayed because immunosuppressive therapy diminishes inflammatory responses. However, if an infection is not identified early enough and treated properly, it can have devastating consequences...
March 2018: Experimental and Clinical Transplantation
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