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lupus, nephropathy, proteinuria, dialysis

Preeti Nargund, Neeraja Kambham, Kshama Mehta, Richard A Lafayette
BACKGROUND: A recent classification of membranoproliferative glomerulonephritis (MPGN) utilizes the presence of immunoglobulin and complements to simplify diagnosis and point towards disease etiology. Here, we evaluate a historic cohort of patients with idiopathic MPGN using the new classification system and correlate it with clinical outcome. METHODS: We identified 281 patients diagnosed with MPGN at Stanford from 2000 to 2012. Patients with hepatitis, systemic lupus erythematosis, lymphomas, and plasma cell dyscrasias were excluded...
December 2015: Clinical Nephrology
Giorgina Barbara Piccoli, Gianfranca Cabiddu, Rossella Attini, Federica Vigotti, Federica Fassio, Alessandro Rolfo, Domenica Giuffrida, Antonello Pani, Piero Gaglioti, Tullia Todros
Chronic kidney disease (CKD) is increasingly encountered in pregnancy because of greater diagnostic awareness, which is a reflection of the newer, broader definitions (i.e., any changes in blood or urine composition or at imaging, or a glomerular filtration rate (GFR) of <60 mL/min lasting at least 3 months) and of increased incidence (higher maternal age and better outcomes of several kidney diseases). CKD is extremely heterogeneous and may be described by the degree of GFR reduction (CKD stages), the presence of proteinuria and hypertension and the type of kidney disease; the risk of adverse pregnancy-related events increases as GFR decreases and it is affected by proteinuria and hypertension...
July 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
Pavan Malleshappa, Ravi Ranganath, Anup P Chaudhari, Ashwinikumar Ayiangar, Suratkal Lohitaksha
We describe a 42-year-old male patient who presented with high grade fever associated with acute renal failure requiring hemodialysis. Renal biopsy revealed that he had focal proliferative glomerulonephritis on light microscopy, dominant mesangial deposition of C1q by immunofluorescent staining, and electron dense deposits on electron microscopy, with no evidence of systemic lupus erythematosus, compatible with the diagnosis of C1q nephropathy. Intensive treatment with a combination of methyl prednisolone pulse therapy and oral prednisolone was successful in achieving complete remission and disappearance of proteinuria in our patient...
March 2011: Saudi Journal of Kidney Diseases and Transplantation
P L Quirós, M Ceballos, C Remón, A Lozano, R del Castillo, E Aznar, M A Pérez Pérez-Ruilópez, M Rivero, E Fernández Ruiz
AIMS: To analyse the histological correspondence, the renal survival and the clinical prognostic factors in the nephrotic syndrome for more than 20 years in our environment as well as the influence of the nephrotic proteinuria in the renal survival in the different histological particular types of glomerulonephritis. PATIENTS AND METHODS: Among the 542 primary and secondary glomerulonephritis diagnosed by kidney biopsy for two decades in the Cadiz Bay Area, we selected 242 patients whose clinical presentation and the biopsy indication was the nephrotic syndrome...
2005: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
G Gamba, L Quintanilla, M D del Bosque, A Chew-Wong, R Correa-Rotter
BACKGROUND: The present study was designed to know the clinical course of lupus nephritis and the risk factors associated with the development of end stage renal disease. METHODS: This a retrospective study performed in a cohort of 154 patients with biopsy proven lupus nephritis that were seen in our hospital between 1984 and 1990. The clinical records of all patients were reviewed in order to collect the following information at the time of the biopsy: age, sex, number and type of lupus criteria according with the American College of Reumathology, mean arterial pressure, serum creatinine, BUN, and albumin, as well as urinary protein excretion...
July 2000: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
T Srivastava, V Chadha, E M Taboada, U S Alon
C1q nephropathy is an immune complex glomerulonephritis defined by the presence of mesangial immunoglobulins and complement deposits, most notably C1q, and the absence of clinical and laboratory evidence of systemic lupus erythematosus. Histology in C1q nephropathy is characterized by a slight to severe increase in mesangial cellularity and matrix, with or without segmental sclerosis. C1q nephropathy usually presents with nephrotic-range proteinuria in older children and young adults, and has a poor response to steroids...
September 2000: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
B I Freedman, J M Soucie, S M Stone, S Pegram
Human immunodeficiency virus-associated nephropathy (HIVAN) develops more often in HIV-infected blacks than whites. Blacks also show marked familial clustering of other causes of end-stage renal disease (ESRD), particularly diabetes mellitus-, hypertension-, and systemic lupus erythematosus-associated ESRD. We compared the family history of ESRD in 201 blacks with ESRD caused by HIVAN (cases) to that of 50 HIV-infected blacks without renal disease (controls) to determine whether HIV-associated ESRD shows familial aggregation...
August 1999: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
C Pauli-Magnus, T Mettang, U Kuhlmann
HISTORY AND CLINICAL FINDINGS: A 20 year old, previously healthy woman presented with a four week history of progressive oedema of the legs and the eyelids and a weight gain of 10 kg. INVESTIGATIONS: Biochemical tests revealed a nephrotic syndrome with a protein-loss in urine of 13.6 g/24 hours and a serum-albumin of 1.2 g/dl. Serological tests showed positive response for antinuclear antibodies, anti-double-stranded-DNA antibodies and cardiolipin antibodies. Renal histology revealed a lupus-associated diffuse membranous nephropathy (WHO-type Vd)...
June 25, 1999: Deutsche Medizinische Wochenschrift
J Strauss, G Zilleruelo, C Abitbol, B Montane, V Pardo
Varying components of the syndrome of human immunodeficiency virus nephropathy (HIVN) have been described, the most pertinent including proteinuria/nephrotic syndrome, progressive azotemia, normal blood pressure, enlarged and hyperechoic kidneys, rapid progression to end-stage renal disease (ESRD), and no response to treatment regimens. The diagnosis of HIVN requires identification of excessive proteinuria or albuminuria, determined by a total protein excretion on a timed urine collection or a high protein/creatinine ratio in a random specimen...
April 1993: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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