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https://www.readbyqxmd.com/read/28614439/residual-volume-in-vials-of-antibiotics-used-in-pediatrics
#1
Caroline Magna Pessoa Chaves, Carolina Martins Bezerra, Francisca Elisângela Teixeira Lima, Maria Vera Lúcia Moreira Leitão Cardoso, Said Gonçalves da Cruz Fonseca, Viviane Martins da Silva
OBJECTIVE: Quantifying residual volume contained in vials of antibiotics used in pediatrics. METHOD: This is an experiment involving samples from vials of antibiotics used in a pediatric hospital. Residual volume was identified by calculating the difference in weight measurement before and after the vials were washed. Evaluation of the residual volume difference in the vials was determined by the Wilcoxon non-parametric test for a sample and established at a significance level of 5%...
June 12, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28611605/different-roles-for-honey-bee-mushroom-bodies-and-central-complex-in-visual-learning-of-colored-lights-in-an-aversive-conditioning-assay
#2
Jenny A Plath, Brian V Entler, Nicholas H Kirkerud, Ulrike Schlegel, C Giovanni Galizia, Andrew B Barron
The honey bee is an excellent visual learner, but we know little about how and why it performs so well, or how visual information is learned by the bee brain. Here we examined the different roles of two key integrative regions of the brain in visual learning: the mushroom bodies and the central complex. We tested bees' learning performance in a new assay of color learning that used electric shock as punishment. In this assay a light field was paired with electric shock. The other half of the conditioning chamber was illuminated with light of a different wavelength and not paired with shocks...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28608525/antimicrobials-used-for-surgical-prophylaxis-by-equine-veterinary-practitioners-in-australia
#3
L Y Hardefeldt, G F Browning, K Thursky, J R Gilkerson, H Billman-Jacobe, M A Stevenson, K E Bailey
BACKGROUND: Antimicrobials are widely used in Australian veterinary practices, but no investigation into the classes of antimicrobials used or the appropriateness of use in horses has been conducted. OBJECTIVES: The aim of the study was to describe antimicrobial use for surgical prophylaxis in equine practice in Australia. STUDY DESIGN: Cross-sectional questionnaire survey. METHODS: An online questionnaire was used to document antimicrobial usage patterns...
June 13, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28580612/utility-of-basophil-activation-testing-to-assess-perioperative-anaphylactic-reactions-in-real-world-practice
#4
Bernadette Eberlein, Sibylle Wigand, Heidrun Lewald, Eberhard Kochs, Johannes Ring, Tilo Biedermann, Ulf Darsow
INTRODUCTION: Perioperative anaphylactic reactions due to drugs and substances associated with general anesthesia can potentially be life-threatening. The objective of this study was to investigate the significance of the basophil activation test (BAT) for allergy diagnosis work up. METHODS: A total of 14 patients (5 men, 9 women; mean age: 57.8 years) with clinical records of anaphylactic reactions under general anesthesia were studied by means of anesthesia records, skin and serological tests...
June 5, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28536632/avoiding-the-side-effects-of-electric-current-pulse-application-to-electroporated-cells-in-disposable-small-volume-cuvettes-assures-good-cell-survival
#5
Maciej Grys, Zbigniew Madeja, Włodzimierz Korohoda
BACKGROUND: The harmful side effects of electroporation to cells due to local changes in pH, the appearance of toxic electrode products, temperature increase, and the heterogeneity of the electric field acting on cells in the cuvettes used for electroporation were observed and discussed in several laboratories. If cells are subjected to weak electric fields for prolonged periods, for example in experiments on cell electrophoresis or galvanotaxis the same effects are seen. In these experiments investigators managed to reduce or eliminate the harmful side effects of electric current application...
2017: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/28526693/a-simple-laboratory-exercise-with-rat-isolated-esophagus-and-stomach-fundus-to-reveal-functional-differences-between-striated-and-smooth-muscle-cells
#6
Francisco José Batista-Lima, Kalinne Kelly Lima Gadelha, Daniel Maia Oliveira, Thiago Brasileiro Vasconcelos, Teresinha Silva Brito, Pedro Jorge Caldas Magalhães
This study describes an undergraduate student laboratory activity using isolated preparations from rat gastrointestinal tissues that possess contractile profiles typically exhibited by striated and smooth muscle cells. While students are introduced to an ex vivo methodology, they can compare differences in trace experiments, twitch aspects, phasic and tonic properties, force-frequency relationships, and pharmacological responsiveness of esophageal (striated) and fundic (smooth muscle) segments. Muscle strips were subjected to electrical field stimulation (EFS) applied by platinum electrodes immersed in the physiological solution...
June 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28492141/procaine-inhibits-proliferation-and-migration-of-colon-cancer-cells-through-inactivation-of-the-erk-mapk-fak-pathways-by-regulation-of-rhoa
#7
Chang Li, Shuohui Gao, Xiaoping Li, Chang Li, Lianjun Ma
Colon cancer is one of the lethal varieties of cancer. Chemotherapy remains to be one of the principal treatment approaches for colon cancer. Anticancer activity of procaine (PCA), which is a local anesthetic drug, has been explored in different studies. In our study, we aimed to explore the anticancer effect of PCA on colon cancer and its underlying mechanism. The results showed that PCA significantly inhibited cell viability, increased the percentage of apoptotic cells and decreased the expression level of RhoA in HCT116 cells in a dose dependent manner (P<0...
May 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28482477/stereocomplex-poly-lactic-acid-nanocoated-chitosan-microparticles-for-the-sustained-release-of-hydrophilic-drugs
#8
Laura Pastorino, Elena Dellacasa, Paola Petrini, Orietta Monticelli
In this work, novel chitosan based microparticles were developed by the layer-by-layer deposition of poly(lactic acid) stereocomplex films on their surface in the view of controlling the release of encapsulated hydrophilic drugs. As first step, the quartz crystal microbalance technique was used to monitor the step-by-step deposition of the stereocomplex layers onto chitosan by evaluating the deposited mass for each layer. Chitosan microparticles, with a size ranging between 40 and 90μm, were then produced by an aerodynamically-assisted jetting technique and covered by a poly(lactic acid) stereocomplex shell...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28338089/neurotoxicity-comparison-of-two-types-of-local-anaesthetics-amide-bupivacaine-versus-ester-procaine
#9
Xu-Jiao Yu, Wei Zhao, Yu-Jie Li, Feng-Xian Li, Zhong-Jie Liu, Hua-Li Xu, Lu-Ying Lai, Rui Xu, Shi-Yuan Xu
Local anaesthetics (LAs) may lead to neurological complications, but the underlying mechanism is still unclear. Many neurotoxicity research studies have examined different LAs, but none have comprehensively explored the distinct mechanisms of neurotoxicity caused by amide- (bupivacaine) and ester- (procaine) type LAs. Here, based on a CCK8 assay, LDH assay, Rhod-2-AM and JC-1 staining, 2',7'-dichlorohy-drofluorescein diacetate and dihydroethidium probes, an alkaline comet assay, and apoptosis assay, we show that both bupivacaine and procaine significantly induce mitochondrial calcium overload and a decline in the mitochondrial membrane potential as well as overproduction of ROS, DNA damage and apoptosis (P < 0...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28285862/comparing-the-effectiveness-of-vapocoolant-spray-and-lidocaine-procaine-cream-in-reducing-pain-of-intravenous-cannulation-a-randomized-clinical-trial
#10
Asghar Dalvandi, Hadi Ranjbar, Maryam Hatamizadeh, Abolfazl Rahgoi, Colleen Bernstein
INTRODUCTION: Venous cannulation is the most common procedure in emergency departments. The aim of this study was to compare the effectiveness of vapocoolant spray and EMLA cream in reduction of pain during venous cannulation in 6-12years old children. METHODS: The study was a randomized clinical trial with a crossover design. It took place between June and December 2015 at Ali-Asghar hospital in Tehran, Iran. 40 Thalassemic children who need regular blood transfusions were randomly assigned in two groups...
February 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28285487/load-carriage-related-paresthesias-part-2-meralgia-paresthetica
#11
REVIEW
Joseph J Knapik, Katy Reynolds, Robin Orr, Rodney Pope
This is the second of a two-part series addressing symptoms, evaluation, and treatment of load carriage- related paresthesias. Part 1 addressed rucksack palsy and digitalgia paresthetica; here, meralgia paresthetica (MP) is discussed. MP is a mononeuropathy involving the lateral femoral cutaneous nerve (LFCN). MP has been reported in load carriage situations where the LFCN was compressed by rucksack hipbelts, pistol belts, parachute harnesses, and body armor. In the US military, the rate of MP is 6.2 cases/10,000 personyears...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28267672/local-anesthetic-effects-of-bupivacaine-loaded-lipid-polymer-hybrid-nanoparticles-in-vitro-and-in-vivo-evaluation
#12
Pengju Ma, Ting Li, Huaixin Xing, Suzhen Wang, Yingui Sun, Xiugui Sheng, Kaiguo Wang
PURPOSE: There is a compelling need for prolonged local anesthetic that would be used for analgesia with a single administration. However, due to the low molecular weight of local anesthetics (LA) (lidocaine, bupivacaine, procaine, dibucaine, etc), they present fast systemic absorption. METHODS: The aim of the present study was to develop and evaluate bupivacaine lipid-polymer hybrid nanoparticles (BVC LPNs), and compared with BVC loaded PLGA nanoparticles (BVC NPs)...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28255796/acute-myocardial-infarction-in-a%C3%A2-patient-suffering-from-penicillin-induced-laryngeal-edema-kounis-syndrome-aggravated-by-adrenaline
#13
Mahmut Yesin, Macit Kalçık, Mustafa Ozan Gürsoy, Süleyman Karakoyun, Metin Çağdaş, Mehmet Özkan
Kounis syndrome or allergic angina is defined as the coincidental occurrence of chest pain and allergic reactions accompanied by clinical and laboratory findings of classical angina pectoris. It is triggered by the action of potent vasoactive and inflammatory mediators, which are released from the mast cells during the allergic reaction. Epinephrine is a life-saving medication in anaphylaxis; however, it can aggravate ischemia and induce coronary vasospasm and arrhythmias. Here, we present a patient with Kounis syndrome that was caused by intramuscular injection of procaine penicillin G, and in whom epinephrine administration for treatment of laryngeal edema had provoked severe myocardial ischemia...
July 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28251881/procaine-inhibits-proliferation-and-migration-and-promotes-cell-apoptosis-in-osteosarcoma-cells-by-upregulation-of-microrna-133b
#14
Boda Ying, Hong Huang, Hongfei Li, Meng Song, Sizhan Wu, Hongliang Ying
Procaine (PCA) is a conventional chemotherapeutic agent for osteosarcoma. Recent study has proposed that the growth-inhibitory effect of PCA was by regulation of microRNAs. MiR-133b has been proved to be a tumor suppressor of osteosarcoma, while whether it was involved in anti-tumor effects of PCA on osteosarcoma has not been investigated. Thus, in this study, we aimed to explore the effects of PCA on osteosarcoma MG63 cells by regulation of miR-133b, as well as its underlying mechanisms. MG63 cells were treated with different concentrations of PCA, and then cell viability, apoptosis and miR-133b were respectively detected by MTT, flow cytometer and qRT-PCR...
March 2, 2017: Oncology Research
https://www.readbyqxmd.com/read/28237801/inactivation-of-the-medial-mammillary-nucleus-attenuates-theta-rhythm-activity-in-the-hippocampus-in-urethane-anesthetized-rats
#15
Witold Żakowski, Łukasz Braszka, Piotr Zawistowski, Jolanta Orzeł-Gryglewska, Edyta Jurkowlaniec
Although the importance of the mammillary body for memory and learning processes is well known, its exact role has remained vague. The fact, that many neurons in one nucleus of the mammillary body in rats, i.e. the medial mammillary nucleus (MM), fires according with hippocampal theta rhythm, makes this structure crucial for a theta rhythm signaling in so-called extended hippocampal system. These neurons are driven by descending projections from the hippocampal formation, but it is still unknown whether the mammillary body only conveys theta rhythm or may also modulate it...
February 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28213242/cocaine-profiling-implementation-of-a-predictive-model-by-atr-ftir-coupled-with-chemometrics-in-forensic-chemistry
#16
Stefano Materazzi, Adolfo Gregori, Luigi Ripani, Azzurra Apriceno, Roberta Risoluti
In this study, a strategy based on Infrared Spectroscopy with Fourier Transformed and Attenuated Total Reflectance associated with chemometrics (ATR-FTIR) is proposed to identify the chemical "fingerprint" of cocaine samples. To this end, standard mixtures of cocaine and cuttings at differents ratio were investigated in order to develop a multivariate classification model to simultaneously predict the composition of the samples and to obtain a profile of adulteration of cocaine seizures. In addition, the application of a Partial Least Squares (PLS) and Principal Component Regression (PCR) calibration approaches were found to be a useful tool to predict the content of cocaine, caffeine, procaine, lidocaine and phenacetin in drug seizures...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28045911/do-quiescence-and-wasp-venom-induced-lethargy-share-common-neuronal-mechanisms-in-cockroaches
#17
Stav Emanuel, Frederic Libersat
The escape behavior of a cockroach may not occur when it is either in a quiescent state or after being stung by the jewel wasp (Ampulex compressa). In the present paper, we show that quiescence is an innate lethargic state during which the cockroach is less responsive to external stimuli. The neuronal mechanism of such a state is poorly understood. In contrast to quiescence, the venom-induced lethargic state is not an innate state in cockroaches. The Jewel Wasp disables the escape behavior of cockroaches by injecting its venom directly in the head ganglia, inside a neuropile called the central complex a 'higher center' known to regulate motor behaviors...
2017: PloS One
https://www.readbyqxmd.com/read/28017670/presynaptic-facilitation-by-tetracaine-of-glutamatergic-spontaneous-excitatory-transmission-in-the-rat-spinal-substantia-gelatinosa-involvement-of-trpa1-channels
#18
Lian-Hua Piao, Tsugumi Fujita, Ting Yu, Eiichi Kumamoto
The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous L-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine reduces the spontaneous release of L-glutamate in SG neurons. In order to determine whether TRPA1 activation by LAs is specific to amide-types, we examined the actions of tetracaine, another ester-type LA, and other amide-type LAs on glutamatergic spontaneous excitatory transmission in SG neurons by focusing on TRP activation...
December 22, 2016: Brain Research
https://www.readbyqxmd.com/read/27988146/simplified-antibiotic-regimens-for-treatment-of-clinical-severe-infection-in-the-outpatient-setting-when-referral-is-not-possible-for-young-infants-in-pakistan-simplified-antibiotic-therapy-trial-satt-a-randomised-open-label-equivalence-trial
#19
Fatima Mir, Imran Nisar, Shiyam S Tikmani, Benazir Baloch, Sadia Shakoor, Fyezah Jehan, Imran Ahmed, Simon Cousens, Anita K M Zaidi
BACKGROUND: Parenteral antibiotic therapy for young infants (aged 0-59 days) with suspected sepsis is sometimes not available or feasible in countries with high neonatal mortality. Outpatient treatment could save lives in such settings. We aimed to assess the equivalence of two simplified antibiotic regimens, comprising fewer injections and oral rather than parenteral administration, compared with a reference treatment for young infants with clinical severe infection. METHODS: We undertook the Simplified Antibiotic Therapy Trial (SATT), a three-arm, randomised, open-label, equivalence trial in five communities in Karachi, Pakistan...
February 2017: Lancet Global Health
https://www.readbyqxmd.com/read/27966316/evaluation-of-cutaneous-anthrax-cases-during-an-outbreak-in-the-east-region-of-turkey
#20
Esra Kural Ünüvar, Deniz Bahar Akgün Karapınar, Nazlı Dizen Namdar
BACKGROUND/AIM: Anthrax is a zoonotic infection caused by Bacillus anthracis. We aimed to retrospectively evaluate cutaneous anthrax cases that occurred during an outbreak in eastern Turkey (Hakkari-Yüksekova), where people mostly earn their living from animal husbandry. MATERIALS AND METHODS: Forty-six cutaneous anthrax patients that were admitted to the hospital during a very short duration of 3 months (June-August 2011) were evaluated. RESULTS: Out of 46 patients, 27 (52%) were women and 19 (48%) were men...
November 17, 2016: Turkish Journal of Medical Sciences
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