Elodie A Lallemand, Alain Bousquet-Mélou, Laura Chapuis, Jennifer Davis, Aude A Ferran, Butch Kukanich, Taisuke Kuroda, Marlène Z Lacroix, Yohei Minamijima, Lena Olsén, Ludovic Pelligand, Felipe Ramon Portugal, Béatrice B Roques, Elizabeth M Santschi, Katherine E Wilson, Pierre-Louis Toutain
INTRODUCTION: The aim of this international project was to establish a species-specific Clinical Breakpoint for interpretation of Antimicrobial Susceptibility Testing of benzylpenicillin (BP) in horses. METHODS: A population pharmacokinetic model of BP disposition was developed to compute PK/PD cutoff values of BP for different formulations that are commonly used in equine medicine around the world (France, Sweden, USA and Japan). Investigated substances were potassium BP, sodium BP, procaine BP, a combination of procaine BP and benzathine BP and penethamate, a prodrug of BP...
2023: Frontiers in Microbiology