Erbao Chen, Zhilin Zou, Rongyue Wang, Jie Liu, Zhen Peng, Zhe Gan, Zewei Lin, Jikui Liu
OBJECTIVE: Significant advancements have been made in hepatocellular carcinoma (HCC) therapeutics, such as immunotherapy for treating patients with HCC. However, there is a lack of reliable biomarkers for predicting the response of patients to therapy, which continues to be challenging. Cancer stem cells (CSCs) are involved in the oncogenesis, drug resistance, and invasion, as well as metastasis of HCC cells. Therefore, in this study, we aimed to create an mRNA expression-based stemness index (mRNAsi) model to predict the response of patients with HCC to immunotherapy...
2024: Frontiers in Immunology