Joon Young Hur, Kyueng-Whan Min, Yung-Kyun Noh, Young-Woong Won, Yoomi Yeo, Dong-Hoon Kim, Byoung Kwan Son, Mi Jung Kwon, Jung Soo Pyo
INTRODUCTION: The CLDN18 gene, encoding claudin 18.1 and claudin 18.2, is a key component of tight junction strands in epithelial cells that form a paracellular barrier that is critical in Stomach Adenocarcinoma (STAD). METHODS: Our study included 1,095 patients with proven STAD, 415 from The Cancer Genome Atlas (TCGA) cohort and 680 from the Gene Expression Omnibus database. We applied various analyses, including gene set enrichment analysis, pathway analysis, and in vitro drug screening to evaluate survival, immune cells, and genes and gene sets associated with cancer progression, based on CLDN18 expression levels...
April 18, 2024: Current Medicinal Chemistry