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https://www.readbyqxmd.com/read/27913746/anti-trachea-inflammatory-effects-of-diosgenin-from-dioscorea-nipponica-through-interactions-with-glucocorticoid-receptor-%C3%AE
#1
Yang Junchao, Wang Zhen, Wang Yuan, Xu Liying, Jiang Libin, Zhu Yuanhong, Zhao Wei, Chen Ruilin, Zhai Lu
Asthma is a heterogeneous disease characterized by symptoms of chronic inflammation and airway structural and functional changes. It affects about 300 million people worldwide and causes 250 000 deaths annually, but its symptoms can be greatly relieved by regular use of inhaled glucocorticoids (GCs). GCs exert their function through interacting with glucocorticoid receptors (GRs). Diosgenin is a naturally occurring steroidal saponin abundantly present in many medicinal plants, including Dioscorea nipponica, which shares a similar steroidal structure with GC...
December 2, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27889894/glucocorticoid-induced-leucine-zipper-in-central-nervous-system-health-and-disease
#2
REVIEW
Mythily Srinivasan, Debomoy K Lahiri
The central nervous system (CNS) is a large network of intercommunicating cells that function to maintain tissue health and homeostasis. Considerable evidence suggests that glucocorticoids exert both neuroprotective and neurodegenerative effects on the CNS. Glucocorticoids act by binding two related receptors in the cytoplasm, the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). The glucocorticoid receptor complex mediates cellular responses by transactivating target genes and by protein: protein interactions...
November 26, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27807817/neutrophil-expression-of-glucocorticoid-induced-leucine-zipper-gilz-anti-inflammatory-protein-is-associated-with-acute-respiratory-distress-syndrome-severity
#3
Marie-Alix Espinasse, David Hajage, Philippe Montravers, Pascale Piednoir, Guillaume Dufour, Florence Tubach, Vanessa Granger, Luc de Chaisemartin, Benoît Noël, Marc Pallardy, Sylvie Chollet-Martin, Armelle Biola-Vidamment
BACKGROUND: Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein involved in neutrophil apoptosis and the resolution of inflammation. Given the numerous pathophysiologic roles of neutrophils in the acute respiratory distress syndrome (ARDS), we postulated that neutrophil GILZ expression might be induced during ARDS, to modulate the inflammatory process and participate in lung repair. METHODS: This single-center, prospective, observational cohort study took place in the surgical intensive care unit of Bichat Hospital (Paris, France) and involved 17 ARDS patients meeting the Berlin criteria at inclusion, and 14 ventilated controls without ARDS...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27793999/glucocorticoid-induced-leucine-zipper-protein-controls-macropinocytosis-in-dendritic-cells
#4
Joseph Calmette, Matthieu Bertrand, Mathias Vétillard, Mehdi Ellouze, Shaun Flint, Valérie Nicolas, Armelle Biola-Vidamment, Marc Pallardy, Eric Morand, Françoise Bachelerie, Véronique Godot, Géraldine Schlecht-Louf
Ag sampling is a key process in dendritic cell (DC) biology. DCs use constitutive macropinocytosis, receptor-mediated endocytosis, and phagocytosis to capture exogenous Ags for presentation to T cells. We investigated the mechanisms that regulate Ag uptake by DCs in the steady-state and after a short-term LPS exposure in vitro and in vivo. We show that the glucocorticoid-induced leucine zipper protein (GILZ), already known to regulate effector versus regulatory T cell activation by DCs, selectively limits macropinocytosis, but not receptor-mediated phagocytosis, in immature and recently activated DCs...
October 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27769714/ultradian-glucocorticoid-exposure-directs-gene-dependent-and-tissue-specific-mrna-expression-patterns-in%C3%A2-vivo
#5
Charlotte L George, Matthew T Birnie, Benjamin P Flynn, Yvonne M Kershaw, Stafford L Lightman, Becky L Conway-Campbell
In this paper we report differential decoding of the ultradian corticosterone signal by glucocorticoid target tissues. Pulsatile corticosterone replacement in adrenalectomised rats resulted in different dynamics of Sgk1 mRNA production, with a distinct pulsatile mRNA induction profile observed in the pituitary in contrast to a non-pulsatile induction in the prefrontal cortex (PFC). We further report the first evidence for pulsatile transcriptional repression of a glucocorticoid-target gene in vivo, with pulsatile regulation of Pomc transcription in pituitary...
January 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27764084/novel-nuclear-factor-kappab-targeting-peptide-suppresses-%C3%AE-amyloid-induced-inflammatory-and-apoptotic-responses-in-neuronal-cells
#6
Mythily Srinivasan, Baindu Bayon, Nipun Chopra, Debomoy K Lahiri
In the central nervous system (CNS), activation of the transcription factor nuclear factor-kappa B (NF-κβ) is associated with both neuronal survival and increased vulnerability to apoptosis. The mechanisms underlying these dichotomous effects are attributed to the composition of NF-κΒ dimers. In Alzheimer's disease (AD), β-amyloid (Aβ) and other aggregates upregulate activation of p65:p50 dimers in CNS cells and enhance transactivation of pathological mediators that cause neuroinflammation and neurodegeneration...
2016: PloS One
https://www.readbyqxmd.com/read/27754177/sy-15-4-role-of-histone-deacetylases-in-regulating-endothelial-and-vascular-function
#7
InKyeom Kim
Histone deacetylases (HDACs) act as co-repressors in gene transcription by erasing the acetylation of histones, resulting in epigenetic gene silencing. Recent studies revealed that HDAC inhibitors attenuated blood pressure of several hypertensive animal models such as spontaneously hypertensive rats, hyperaldosteronism rats, angiotensin II-induced hypertensive rats and pulmonary hypertensive rats. Unexpectedly, microarray studies uncovered that administration of HDAC inhibitors decreased expression of some genes for example extracellular matrix proteins, oxidative stress-related proteins, cytokines, chemokines and ion transporters, mostly targets of corticoid receptors...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27716396/glucocorticoid-induced-leucine-zipper-gilz-is-involved-in-glucocorticoid-induced-and-mineralocorticoid-induced-leptin-production-by-osteoarthritis-synovial-fibroblasts
#8
Olivier Malaise, Biserka Relic, Edith Charlier, Mustapha Zeddou, Sophie Neuville, Céline Deroyer, Philippe Gillet, Edouard Louis, Michel G Malaise, Dominique de Seny
BACKGROUND: Glucocorticoid-induced leucine zipper (GILZ) is a mediator of the anti-inflammatory activities of glucocorticoids. However, GILZ deletion does not impair the anti-inflammatory activities of exogenous glucocorticoids in mice arthritis models and GILZ could also mediate some glucocorticoid-related adverse events. Osteoarthritis (OA) is a metabolic disorder that is partly attributed to adipokines such as leptin, and we previously observed that glucocorticoids induced leptin secretion in OA synovial fibroblasts...
October 4, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27643134/sy-15-4-role-of-histone-deacetylases-in-regulating-endothelial-and-vascular-function
#9
InKyeom Kim
Histone deacetylases (HDACs) act as co-repressors in gene transcription by erasing the acetylation of histones, resulting in epigenetic gene silencing. Recent studies revealed that HDAC inhibitors attenuated blood pressure of several hypertensive animal models such as spontaneously hypertensive rats, hyperaldosteronism rats, angiotensin II-induced hypertensive rats and pulmonary hypertensive rats. Unexpectedly, microarray studies uncovered that administration of HDAC inhibitors decreased expression of some genes for example extracellular matrix proteins, oxidative stress-related proteins, cytokines, chemokines and ion transporters, mostly targets of corticoid receptors...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27629417/induction-of-glucocorticoid-induced-leucine-zipper-gilz-contributes-to-anti-inflammatory-effects-of-the-natural-product-curcumin-in-macrophages
#10
Jessica Hoppstädter, Nina Hachenthal, Jenny Vanessa Valbuena-Perez, Sebastian Lampe, Ksenia Astanina, Michael M Kunze, Stefano Bruscoli, Carlo Riccardi, Tobias Schmid, Britta Diesel, Alexandra K Kiemer
GILZ (glucocorticoid-induced leucine zipper) is inducible by glucocorticoids and plays a key role in their mode of action. GILZ attenuates inflammation mainly by inhibition of NF-κB and mitogen-activated protein kinase activation but does not seem to be involved in the severe side effects observed after glucocorticoid treatment. Therefore, GILZ might be a promising target for new therapeutic approaches. The present work focuses on the natural product curcumin, which has previously been reported to inhibit NF-κB...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27501780/protein-phosphatase-5-mediates-corticosteroid-insensitivity-in-airway-smooth-muscle-in-patients-with-severe-asthma
#11
L Chachi, M Abbasian, A Gavrila, A Alzahrani, O Tliba, P Bradding, A J Wardlaw, C Brightling, Y Amrani
BACKGROUND: The mechanisms driving glucocorticoid (GC) insensitivity in patients with severe asthma are still unknown. Recent evidence suggests the existence of GC-insensitive pathways in airway smooth muscle (ASM) caused by a defect in GC receptor (GRα) function. We examined whether other mechanisms could potentially explain the reduced sensitivity of ASM cells to GC in severe asthmatics. METHODS: Airway smooth muscle cells from healthy and severe asthmatic subjects were treated with TNF-α and responses to corticosteroids in both cohorts were compared by ELISA, immunoblot, immunohistochemistry and real-time PCR...
August 9, 2016: Allergy
https://www.readbyqxmd.com/read/27465291/melanoma-dormancy-in-a-mouse-model-is-linked-to-gilz-foxo3a-dependent-quiescence-of-disseminated-stem-like-cells
#12
Yasmine Touil, Pascaline Segard, Pauline Ostyn, Severine Begard, Caroline Aspord, Raja El Machhour, Bernadette Masselot, Jerome Vandomme, Pilar Flamenco, Thierry Idziorek, Martin Figeac, Pierre Formstecher, Bruno Quesnel, Renata Polakowska
Metastatic cancer relapses following the reactivation of dormant, disseminated tumour cells; however, the cells and factors involved in this reactivation are just beginning to be identified. Using an immunotherapy-based syngeneic model of melanoma dormancy and GFP-labelled dormant cell-derived cell lines, we determined that vaccination against melanoma prevented tumour growth but did not prevent tumour cell dissemination or eliminate all tumour cells. The persistent disseminated melanoma tumour cells were quiescent and asymptomatic for one year...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27416758/gilz-overexpression-attenuates-endoplasmic-reticulum-stress-mediated-cell-death-via-the-activation-of-mitochondrial-oxidative-phosphorylation
#13
Fanny André, Paola Corazao-Rozas, Thierry Idziorek, Bruno Quesnel, Jérome Kluza, Philippe Marchetti
The Glucocorticoïd-induced leucine zipper (GILZ) protein has profound anti-inflammatory activities in haematopoietic cells. GILZ regulates numerous signal transduction pathways involved in proliferation and survival of normal and neoplastic cells. Here, we have demonstrated the potential of GILZ in alleviating apoptosis induced by ER stress inducers. Whereas the glucocorticoid, dexamethasone, protects from tunicamycin-induced cell death, silencing endogeneous GILZ in dexamethasone-treated cancer cells alter the capacity of glucocorticoids to protect from tunicamycin-mediated apoptosis...
September 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27220430/vitamin-d-interferes-with-glucocorticoid-responsiveness%C3%A2-in-human-peripheral-blood-mononuclear-target-cells
#14
Eva Kassi, Narjes Nasiri-Ansari, Eliana Spilioti, Vassiliki Kalotychou, Panagiota E Apostolou, Paraskevi Moutsatsou, Athanasios G Papavassiliou
Glucocorticoids (GCs) are widely used in the treatment of inflammatory and autoimmune diseases; however, patients are often resistant to GC effects. Current studies indicate that vitamin D reduces the risk or modifies the course of autoimmune diseases posing vitamin D supplementation as a prevention or therapeutic option. Herein, we investigated whether vitamin D can modify the response to GCs at the molecular level. To this end, peripheral blood mononuclear cells (PBMCs) were isolated from healthy vitamin D-deficient women and incubated with either the active metabolite 1,25(OH)2D3 (VitD) for 11 days or dexamethasone (Dex) for the last 2 days in the presence or absence of VitD...
May 24, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27178044/low-expression-of-the-gilz-may-contribute-to-adipose-inflammation-and-altered-adipokine-production-in-human-obesity
#15
Mi-Jeong Lee, Rong-Ze Yang, Kalypso Karastergiou, Steven R Smith, Jeffery R Chang, Da-Wei Gong, Susan K Fried
The glucocorticoid-induced leucine zipper (GILZ), a primary target of glucocorticoids, is expressed in human adipocytes, but its importance in adipocyte function is unknown. Because TNFα is increased in obese adipose tissue and antagonizes a number of glucocorticoid actions, we investigated the interplay of these pathways. GILZ knockdown increased and GILZ overexpression decreased interleukin-6 (IL-6) and leptin mRNA and protein secretion. GILZ knockdown increased the magnitude of the glucocorticoid effect on leptin secretion, but did not affect the glucocorticoid suppression of IL-6...
July 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27031999/peripheral-circadian-clocks-are-diversely-affected-by-adrenalectomy
#16
M Soták, J Bryndová, P Ergang, K Vagnerová, P Kvapilová, M Vodička, J Pácha, A Sumová
Glucocorticoids are considered to synchronize the rhythmicity of clock genes in peripheral tissues; however, the role of circadian variations of endogenous glucocorticoids is not well defined. In the present study, we examined whether peripheral circadian clocks were impaired by adrenalectomy. To achieve this, we tested the circadian rhythmicity of core clock genes (Bmal1, Per1-3, Cry1, RevErbα, Rora), clock-output genes (Dbp, E4bp4) and a glucocorticoid- and clock-controlled gene (Gilz) in liver, jejunum, kidney cortex, splenocytes and visceral adipose tissue (VAT)...
2016: Chronobiology International
https://www.readbyqxmd.com/read/26639395/decreased-expression-of-the-glucocorticoid-receptor-gilz-pathway-in-kupffer-cells-promotes-liver-inflammation-in-obese-mice
#17
Olivier Robert, Hédia Boujedidi, Amélie Bigorgne, Gladys Ferrere, Cosmin Sebastian Voican, Sabine Vettorazzi, Jan Peter Tuckermann, Laurence Bouchet-Delbos, Thi Tran, Patrice Hemon, Virginie Puchois, Ibrahim Dagher, Richard Douard, Francoise Gaudin, Hélène Gary-Gouy, Francis Capel, Ingrid Durand-Gasselin, Sophie Prévot, Sophie Rousset, Sylvie Naveau, Véronique Godot, Dominique Emilie, Marc Lombès, Gabriel Perlemuter, Anne-Marie Cassard
BACKGROUND & AIMS: Kupffer cells (KC) play a key role in the onset of inflammation in non-alcoholic steatohepatitis (NASH). The glucocorticoid receptor (GR) induces glucocorticoid-induced leucine zipper (GILZ) expression in monocytes/macrophages and is involved in several inflammatory processes. We hypothesized that the GR-GILZ axis in KC may contribute to the pathophysiology of obesity-induced liver inflammation. METHODS: By using a combination of primary cell culture, pharmacological experiments, mice deficient for the Gr specifically in macrophages and transgenic mice overexpressing Gilz in macrophages, we explored the involvement of the Gr-Gilz axis in KC in the pathophysiology of obesity-induced liver inflammation...
April 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/26617572/gilz-as-a-mediator-of-the-anti-inflammatory-effects-of-glucocorticoids
#18
REVIEW
Simona Ronchetti, Graziella Migliorati, Carlo Riccardi
Glucocorticoid-induced leucine zipper (GILZ) is a dexamethasone-inducible gene that mediates glucocorticoid (GC) actions in a variety of cell types, including many cells of immune system. In particular, GILZ can control T cell activities, such as activation and differentiation, mainly through its ability to homo- and hetero-dimerize with partner proteins, such as NF-κB, Ras, and C/EBP. These protein-protein interactions control the regulation of pro-inflammatory target genes. A number of in vitro and in vivo studies using mouse models of inflammatory diseases demonstrate an anti-inflammatory role for GILZ...
2015: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/26612340/glucocorticoid-induced-leucine-zipper-gilz-inhibits-b-cell-activation-in-systemic-lupus-erythematosus
#19
Sarah A Jones, Andrew E J Toh, Dragana Odobasic, Marie-Anne Virginie Oudin, Qiang Cheng, Jacinta P W Lee, Stefan J White, Brendan E Russ, Simona Infantino, Amanda Light, David M Tarlinton, James Harris, Eric F Morand
OBJECTIVES: Systemic lupus erythematosus (SLE) is a serious multisystem autoimmune disease, mediated by disrupted B cell quiescence and typically treated with glucocorticoids. We studied whether B cells in SLE are regulated by the glucocorticoid-induced leucine zipper (GILZ) protein, an endogenous mediator of anti-inflammatory effects of glucocorticoids. METHODS: We conducted a study of GILZ expression in blood mononuclear cells of patients with SLE, performed in vitro analyses of GILZ function in mouse and human B cells, assessed the contributions of GILZ to autoimmunity in mice, and used the nitrophenol coupled to keyhole limpet haemocyanin model of immunisation in mice...
April 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26545644/effect-of-chia-seed-salvia-hispanica-l-consumption-on-cardiovascular-risk-factors-in-humans-a-systematic-review
#20
Cynthia de Souza Ferreira, Lucilia de Fátima dd Sousa Fomes, Gilze Espirito Santo da Silva, Glorimar Rosa
INTRODUCTION: chia is a seed rich in such nutrients as proteins, n-3 fatty acids and especially alpha-linolenic acid (ALA), minerals, fibers and antioxidants. Efforts have been made to assess whether human consumption of chia can reduce cardiovascular risk factors; however, it has not been established as effective and the findings of the few studies to have looked into the matter are inconsistent. AIM: to systematize the findings of studies assessing the effect the consumption of chia seed, either milled or whole, has in the prevention/control of cardiovascular risk factors in humans...
November 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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