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Prolo therapy

Muhammad Irfan, Joveria Farooqi, Rumina Hasan
PURPOSE OF REVIEW: Community-acquired pneumonia (CAP) contributes significantly to morbidity and mortality, especially in the elderly. Recent advances aimed at improving outcomes and reducing CAP disease burden are summarized. RECENT FINDINGS: Emerging data suggests that newer CAP risk stratification indices based on disease severity hold promise in predicting intensive care need. Additional evidence supports a role of procalcitonin and pro-adrenomedullin as biomarkers of disease severity and for guiding antimicrobial therapy...
May 2013: Current Opinion in Pulmonary Medicine
Roberto Assietti, Mario Morosi, Jon E Block
OBJECT: Degeneration of the intervertebral disc can be the source of severe low-back pain. Intradiscal electrothermal therapy (IDET) is a minimally invasive treatment option for patients with symptomatic internal disc disruption unresponsive to conservative medical care. This study was undertaken in the neurosurgical setting to evaluate 24-month pain and functional outcomes and predictors of clinical success in patients with discogenic back pain treated with IDET. METHODS: Using MR imaging and discography findings, 50 patients with lumbar discogenic pain were identified, underwent IDET treatment, and were followed up for 24 months...
March 2010: Journal of Neurosurgery. Spine
Claudio Yampolsky, Marcelo Corti, Ricardo Negroni
BACKGROUND: Intracranial fungal masses are uncommon diseases, but their incidence is increasing, most often due to the prolonged survival of patients with different immunodeficiencies. The management of patients with intracranial fungal masses included stereotactic biopsy for diagnosis, partial or radical surgery excision and prolonged antifungal therapy. AIMS: We report the case of a 51-year-old diabetic man with a history of psoas abscess due to Candida albicans 1 year before the onset of neurological symptoms, including headache and generalized tonoclonic seizures...
March 31, 2010: Revista Iberoamericana de Micología
Rafael Bárcena, Ana Moreno, José R Foruny, Javier Blázquez, Javier Graus, José M Riesco, Carlos Blesa, Fernando García-Hoz, Juan Sánchez, Luis Gil-Grande, Javier Nuño, Jesús Fortún, Miguel A Rodriguez-Sagrado, Alberto Moreno
BACKGROUND: There is limited information on the long-term outcome in liver transplant (LT) subjects undergoing partial splenic embolization (PSE) prior to full dose pegylated interferon/ribavirin (peg-IFN/RBV). METHODS: Retrospective review of eight LT subjects after PSE and antiviral therapy. RESULTS: Baseline platelets and neutrophils were <50 000 cells/mL and <1000 cells/mL in 75% and 50%. Mean splenic infarction volume was 85 +/- 13%...
May 2010: Clinical Transplantation
Garrick C Stewart, Kimberly Brooks, Parakash P Pratibhu, Sui W Tsang, Marc J Semigran, Colleen M Smith, Catherine Saniuk, Janice M Camuso, James C Fang, Gilbert H Mudge, Gregory S Couper, Kenneth L Baughman, Lynne W Stevenson
BACKGROUND: Current implantable left ventricular assist devices (LVAD) improve survival and function for patients with very late stage heart failure (HF) but may also offer benefit before inotrope dependence. Debate continues about selection of HF patients for LVAD therapy. We sought to determine what level of personal risk and disability HF patients thought would warrant LVAD therapy. METHODS: The study included 105 patients with symptomatic HF and an LV ejection fraction (EF) < 35% who were given a written paragraph about LVADs and asked about circumstances under which they would consider such a device...
September 2009: Journal of Heart and Lung Transplantation
Babita Ghai, Jeetinder Kaur Makkar, Pramila Chari, Katragadda Lakshmi Narasimha Rao
STUDY OBJECTIVE: To investigate the effect of adding midazolam to continuous epidural infusion of bupivacaine for postoperative analgesia in children. DESIGN: Prospective, randomized, double-blind, controlled study. SETTING: Tertiary-care center. PATIENTS: 44 ASA physical status I and II children in age groups of two to 10 years, undergoing elective upper abdominal and flank surgery. INTERVENTIONS: At the end of surgery, patients were randomly allocated to receive epidural infusion of 0...
March 2009: Journal of Clinical Anesthesia
Krzysztof R Radziszewski
UNLABELLED: Discopathy of lumbar spine inevitably leads to decreased quality of life in patients. Decrease of the backbone dysfunction at the degree which makes leading a life close to the normal style of family, social and professional life impossible, is the key therapeutic task. Evaluation of the functional disability can be the objective method of evaluation of the treatment efficacy. The purpose of this study was to analyze of the functional state in patients with lumbar discopathy receiving either conservative therapy only or surgical treatment...
2008: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Francesco Costa, Marco Sassi, Andrea Cardia, Alessandro Ortolina, Antonio De Santis, Giovanni Luccarell, Maurizio Fornari
OBJECT: Surgical decompression is the recommended treatment in patients with moderate to severe degenerative lumbar spinal stenosis (DLSS) in whom symptoms do not respond to conservative therapy. Multilevel disease, poor patient health, and advanced age are generally considered predictors of a poor outcome after surgery, essentially because of a surgical technique that has always been considered invasive and prone to causing postoperative instability. The authors present a minimally invasive surgical technique performed using a unilateral approach for lumbar decompression...
December 2007: Journal of Neurosurgery. Spine
Andrew M Arnold, Lesley Seymour, Michael Smylie, Keyue Ding, Yee Ung, Brian Findlay, Christopher W Lee, Marina Djurfeldt, Marlo Whitehead, Peter Ellis, Glenwood Goss, Adrien Chan, Jacinta Meharchand, Yasmin Alam, Richard Gregg, Charles Butts, Peter Langmuir, Frances Shepherd et al.
PURPOSE: This double-blind randomized phase II trial examined whether vandetanib, an inhibitor of vascular endothelial and epidermal growth factor receptors, could prolong progression-free survival in responding patients with small-cell lung cancer. PATIENTS AND METHODS: Eligible patients with complete response (CR) or partial response (PR) to combination chemotherapy (+/- thoracic or prophylactic cranial radiation) received oral vandetanib 300 mg/d or matched placebo...
September 20, 2007: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
V Craig Jordan, Joan Lewis-Wambi, Helen Kim, Heather Cunliffe, Eric Ariazi, Catherine G N Sharma, Heather A Shupp, Ramona Swaby
The ubiquitous application of selective oestrogen receptor modulators (SERMs) and aromatase inhibitors for the treatment and prevention of breast cancer has created a significant advance in patient care. However, the consequence of prolonged treatment with antihormonal therapy is the development of drug resistance. Nevertheless, the systematic description of models of drug resistance to SERMs and aromatase inhibitors has resulted in the discovery of a vulnerability in tumour homeostasis that can be exploited to improve patient care...
December 2007: Breast: Official Journal of the European Society of Mastology
Sung Yong Oh, Hyuk-Chan Kwon, Won Seog Kim, In Gyu Hwang, Yeon Hee Park, Kihyun Kim, Young Hae Ko, Baek-Yeol Ryoo, Hye Jin Kang, Eunmi Nam, Jae-Hoon Lee, Jung Han Kim, Hyo-Jin Kim
Intestinal marginal zone B-cell lymphoma of the MALT type (I-MZL) is a relatively uncommon form of lymphoma. Twenty-seven patients with histologically-confirmed I-MZL were analyzed. The patients initially presented with abdominal pain (62.9%), and diarrhea (22.2%). The most common involved site was the ileo-caecal area (40.7%). Musshoff's stage I(E), II(E)1, II(E)2, III(E) and IV were present in 44%, 15%, 11%, 7.4% and 22% respectively. Sixty-three percent were in the low-risk group according to the Follicular Lymphoma International Prognostic Index...
October 2007: European Journal of Haematology
April F Eichler, Jay S Loeffler
Metastatic brain tumors are the most common intracranial neoplasms in adults. The incidence of brain metastases appears to be rising as a result of superior imaging modalities, earlier detection, and more effective treatment of systemic disease. Therapeutic approaches to brain metastases include surgery, whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), and chemotherapy. Treatment decisions must take into account clinical prognostic factors in order to maximize survival and neurologic function whilst avoiding unnecessary treatments...
July 2007: Oncologist
Janet Bauer, Sue Spackman, Francesco Chiappelli, Paolo Prolo
Shared decision making empowers patients as informed consumers, helping them to make clinical decisions that optimize their personal oral health. Evidence-based dentistry supports this process by providing best evidence that, when presented in visual and interactive formats, focuses consultation time on treatment or therapy options and their trade-offs. Currently, an explosion of evidence and technological advancements have necessitated a cooperation that translates into an interdisciplinary approach to care delivery...
December 2005: Journal of Evidence-based Dental Practice
Paul Brach, Robert J Goitz
Elbow arthroscopy allows for direct visualization into the elbow joint, minimizes the potential for postoperative edema and discomfort, as well as protects the ligamentous structures. Arthroscopic procedures for the elbow and postoperative management are described for patients who have undergone loose body removal, synovectomy, and capsulectomy. The effect of early mobilization on the elbow complex and the role that splinting may play, as well as the controversies surrounding the use of continuous passive motion are discussed...
April 2006: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
M Engelhardt, M Wolzik, C Brenke, S Lücke, M Scholz, A Harders, K Schmieder
AIM: Surgery in cervical spine disease using titanium cages is a common procedure to reduce the pain and neurological deficits. This study was aimed to evaluate the results in pain reduction using the wing cage intraoperatively. METHOD: In this prospective study demographic data were noted, whereas special emphasis was placed on pain, which was noted using a visual pain scale and the prolo score, neurological deficits and the causing pathology. Furthermore, questions about the use of analgesics and the duration of pain were asked...
September 2005: Zeitschrift Für Orthopädie und Ihre Grenzgebiete
Yong Ahn, Sang-Ho Lee, Song-Woo Shin
OBJECTIVE: The purpose of this study was to evaluate the clinical outcome and radiographic changes of percutaneous endoscopic cervical discectomy (PECD) with the high-resolution working channel endoscope. BACKGROUND DATA: Percutaneous disc decompression using a laser and/or microforceps for cervical disc herniation has been regarded as an effective treatment modality in selected cases. However, the postoperative radiographic changes have not yet been evaluated. METHODS: We reviewed the clinical and radiographic records of 36 consecutive patients who underwent PECD with the working channel endoscope...
August 2005: Photomedicine and Laser Surgery
Rochelle E Curtis, Catherine Metayer, J Douglas Rizzo, Gérard Socié, Kathleen A Sobocinski, Mary E D Flowers, William D Travis, Lois B Travis, Mary M Horowitz, H Joachim Deeg
Previous studies of recipients of hematopoietic stem-cell transplants suggest that graft-versus-host disease (GVHD) and its therapy may increase the risk for solid cancers, particularly squamous-cell carcinomas (SCCs) of the buccal cavity and skin. However, the importance and magnitude of these associations are not well characterized. We conducted a case-control study of 183 patients with posttransplantation solid cancers (58 SCCs, 125 non-SCCs) and 501 matched control patients within a cohort of 24,011 patients who underwent hematopoietic stem-cell transplantation (HSCT) at 215 centers worldwide...
May 15, 2005: Blood
Martin Koestenberger, Gerhard Cvirn, Siegfried Gallistl, Wolfgang Muntean
Recombinant human activated protein C (rhAPC) has recently been demonstrated to be a promising candidate to improve the outcome for patients with severe sepsis. Plasma-derived activated protein C and unfractionated heparin (UH) exert anticoagulant synergy due to mechanisms that simultaneously decrease thrombin generation. Melagatran, a new direct thrombin inhibitor, does not bind to plasma proteins or requires antithrombin as a cofactor. The latter is often consumed in patients with severe sepsis. We investigated the anticoagulant efficiency in combined administration of rhAPC and UH or melagatran in terms of prolongation of the standard clotting assays activated partial thromboplastin time (aPTT) and prothrombin time (PT) in pooled plasma samples in vitro...
October 2004: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Praveen V Mummaneni, Jeff Pan, Regis W Haid, Gerald E Rodts
OBJECT: The authors compared fusion rates in transforaminal lumbar interbody fusion (TLIFs) when using either autograft or bone morphogenetic protein (BMP) placed in the interbody space. METHODS: Between September 2002 and December 2003, the authors performed 44 TLIF operations. Follow-up data were available for 40 patients. Of the 40 procedures, 19 involved cages filled with iliac crest autograft (Group 1) and 21 involved cages filled with a medium kit of recombinant human (rh) BMP-2 (Group 2)...
July 2004: Journal of Neurosurgery. Spine
Patrick M Tarwater, Michelle Parish, Joel E Gallant
Duration of treatment interruption (TI) was investigated in 105 human immunodeficiency virus-infected patients whose antiretroviral therapy was interrupted with the intention to resume therapy on the basis of clinical or laboratory indicators. In a mixed cohort study, 57% of patients had not resumed therapy at the time of writing (median TI duration, 114 weeks); the most recent analysis of this group revealed a mean CD4 cell count of 500 cells/mm3. Patients with lower CD4 cell counts at therapy initiation were more likely to resume therapy than were those with counts of >500 cells/mm3 (<200 cells/mm3 [relative hazard, 4...
December 1, 2003: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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