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https://www.readbyqxmd.com/read/28092204/impact-of-combination-therapy-and-early-de-escalation-on-outcome-of-ventilator-associated-pneumonia-caused-by-pseudomonas-aeruginosa
#1
Laurène Deconinck, Agnès Meybeck, Pierre Patoz, Nicolas Van Grunderbeeck, Nicolas Boussekey, Arnaud Chiche, Pierre-Yves Delannoy, Hugues Georges, Olivier Leroy
BACKGROUND: Pseudomonas aeruginosa is a common cause of ventilator-associated pneumonia (VAP). Guidelines recommend dual coverage of P. aeruginosa, but the beneficial effect of combination therapy is controversial. We described antibiotic prescriptions and evaluated the clinical impact of initial combination antibiotic therapy and de-escalation strategy in patients with VAP caused by P. aeruginosa. METHODS: Between 1994 and 2014, all 100 patients with VAP caused by P...
January 16, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28074125/shiga-vero-toxin-producing-escherichia-coli-isolated-from-the-hospital-foods-virulence-factors-o-serogroups-and-antimicrobial-resistance-properties
#2
Reza Ranjbar, Mojtaba Masoudimanesh, Farhad Safarpoor Dehkordi, Nematollah Jonaidi-Jafari, Ebrahim Rahimi
BACKGROUND: According to the presence of the weak, diabetic and immunosuppressive patients in hospitals, hospital foods should have a high quality and safety. Cooking a lot of foods higher than daily requirement, storage of cooked foods in an inappropriate condition and presence of nurses and servants in distribution of food to patients are the main reasons caused contamination of hospital foods. Shiga toxigenic Escherichia coli is one of the common cause of food poisoning in hospitals...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28064169/potentially-inappropriate-medication-prescribing-is-associated-with-socioeconomic-factors-a-spatial-analysis-in-the-french-nord-pas-de-calais-region
#3
Jean-Baptiste Beuscart, Michael Genin, Corrine Dupont, David Verloop, Alain Duhamel, Marguerite-Marie Defebvre, François Puisieux
BACKGROUND: potentially inappropriate medication (PIM) prescribing is common in older people and leads to adverse events and hospital admissions. OBJECTIVE: to determine whether prevalence of PIM prescribing varies according to healthcare supply and socioeconomic status. METHODS: all prescriptions dispensed at community pharmacies for patients aged 75 and older between 1 January  and 31 March 2012 were retrieved from French Health Insurance Information System of the Nord-Pas-de-Calais Region for patients affiliated to the Social Security scheme...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28064167/potentially-inappropriate-prescribing-to-older-patients-in-primary-care-in-the-netherlands-a-retrospective-longitudinal-study
#4
Linette Bruin-Huisman, Ameen Abu-Hanna, Henk C P M van Weert, Erna Beers
BACKGROUND: potentially inappropriate prescribing (PIP) is associated with adverse health effects in older patients. PIP comprises prescription of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs). OBJECTIVE: to estimate the prevalence of PIMs and PPOs among older patients in primary care. DESIGN: retrospective longitudinal study. SETTING: routinely collected data of 182,000 patients of 49 general practitioners (GPs) gathered in the GPs' database of the Academic Medical Center of Amsterdam, the Netherlands...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28063606/-assessment-of-antibiotic-use-and-impact-of-an-intervention-intended-to-modify-the-prescribing-behavior-in-surgical-prophylaxis-in-6hospitals-in-the-metropolitan-area-of-monterrey-mexico
#5
Gerardo Del Carmen Palacios-Saucedo, Mauricio de la Garza-Camargo, Evangelina Briones-Lara, Sandra Carmona-González, Ricardo García-Cabello, Luis Arturo Islas-Esparza, Gustavo Saldaña-Flores, Juan Roberto González-Cano, Román González-Ruvalcaba, Francisco Javier Valadez-Botello, Gerardo Enrique Muñoz-Maldonado, Carlos Alberto Montero-Cantú, Rita Delia Díaz-Ramos, Fortino Solórzano-Santos
BACKGROUND: Improper use of antibiotics increases antimicrobial resistance. OBJECTIVE: Evaluate the use of antibiotics and the impact of an intervention designed to improve antibiotic prescription for surgical prophylaxis in 6 hospitals of Monterrey, Mexico. MATERIAL AND METHODS: Design: A prospective multicenter survey and a pretest-postest experimental study. Phase 1: Survey to evaluate the use of antibiotics through an especially designed guide...
January 4, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28062684/sale-of-antibiotics-without-a-prescription-at-community-pharmacies-in-urban-china-a-multicentre-cross-sectional-survey
#6
Jie Chang, Dan Ye, Bing Lv, Minghuan Jiang, Shan Zhu, Kangkang Yan, Yun Tian, Yu Fang
OBJECTIVES: To quantify sales of antibiotics without a medical prescription and to assess the quality of pharmacy services in relation to the antibiotics sold in community pharmacies in urban China. METHODS: A multicentre cross-sectional survey of community pharmacies was undertaken in 2015 using the simulated client method. Two clinical case scenarios (paediatric diarrhoea and adult acute upper respiratory infection) were presented at systematically sampled community pharmacies in Eastern (Nanjing), Central (Changsha) and Western China (Xi'an)...
January 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28059431/evaluation-of-treatment-changes-following-electronic-consultation-to-a-pharmacist-run-urine-drug-testing-service-in-a-veterans-healthcare-system
#7
Michelle M Stammet, Shelley S Spradley
In 2013, the North Florida/South Georgia Veterans Healthcare System established a pharmacist-run urine drug testing (UDT) electronic consultation (e-consult) service to assist providers with interpretation of this useful yet complex clinical tool. This pilot study aimed to classify clinical treatment changes implemented following e-consult to a pharmacist-run UDT service and analyze factors limiting pharmacist intervention postconsultation. One hundred forty-three e-consults were completed in the 2-year study period including interpretation of 190 UDT results classified as expected, unexpected, or not necessarily inappropriate based on prescription profile at time of urine immunoassay test...
November 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/28057873/attainment-of-guideline-targets-in-eurodopps-haemodialysis-patients-are-differences-related-to-a-country-s-healthcare-expenditure-and-nephrologist-workforce
#8
Sophie Liabeuf, Karlijn J Van Stralen, Fergus Caskey, Francesca Tentori, Ronald L Pisoni, Ayesha Sajjad, Kitty J Jager, Ziad A Massy
BACKGROUND: In the field of chronic kidney disease, global clinical practice guidelines have been developed and implemented with a view to improving patient care and outcomes. The attainment of international and European guideline targets for haemodialysis patients in European countries has not been audited recently. Hence, we sought to establish whether the attainment of the targets set out in guidelines and inappropriate care are similar across European countries and whether inter-country differences are related to disparities in national healthcare expenditures (as a percentage of gross domestic product) and/or the nephrologist workforce per capita...
January 5, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28056068/the-association-between-polypharmacy-and-dementia-a-nested-case-control-study-based-on-a-12-year-longitudinal-cohort-database-in-south-korea
#9
Hae-Young Park, Ji-Won Park, Hong Ji Song, Hyun Soon Sohn, Jin-Won Kwon
Dementia is a major concern among growing chronic diseases in the aging society and its association with polypharmacy has not been adequately assessed. The objective of this study was to determine the association between polypharmacy and dementia through multiple statistical approaches. We conducted a nested case-control study for newly diagnosed dementia cases using the South Korean National Health Insurance Service sample cohort database (2002-2013, n = 1,025,340). Interactions between polypharmacy (an average use of ≥5 prescription drugs daily) and comorbidities or potentially inappropriate medications (PIMs) were tested...
2017: PloS One
https://www.readbyqxmd.com/read/28053591/potentially-inappropriate-medications-prescribed-for-elderly-patients-through-family-physicians
#10
Abdulaziz Al Odhayani, Ayla Tourkmani, Mohammed Alshehri, Hala Alqahtani, Adel Mishriky
The elderly population is increasing throughout the globe, resulting in higher healthcare costs. Potential inappropriate medication (PIM) prescriptions are a major health problem affecting the elderly persons. Due to limited studies in PIM use in primary care and home healthcare in Saudi Arabia, we aim to examine the extent of PIM prescription for and use by elderly patients. This study was carried out with 798 elderly patients, arbitrarily selected from Prince Sultan Medical Military City through the patient register...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28049239/from-visiting-a-physician-to-expecting-antibiotics-korean-perspectives-and-practices-toward-respiratory-tract-infections
#11
Leila Freidoony, Chun Bae Kim, Hamid Haghani, Myung Bae Park, Sei Jin Chang, Sang Ha Kim, Sang Baek Koh
Antibiotic resistance is steadily rising worldwide. Respiratory tract infections (RTIs) are common indications, mostly imprudent, for antibiotic prescriptions in outpatient setting. In Korea, antibiotic prescription rate for RTIs is still high. As physician visit and antibiotic prescribing are influenced by patient's perceptions and beliefs, we aimed to explore the general public's perspectives and practices toward RTIs and to develop the 'RTI clinical iceberg.' A cross-sectional survey was conducted in Wonju Severance Christian Hospital (WSCH) among 550 adults attending outpatient departments during January 2016...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28042352/potentially-inappropriate-prescribing-andthe-risk-of-adverse-drug-reactions-in-critically-ill-older-adults
#12
Thamires B Galli, Wálleri C Reis, Vânia M Andrzejevski
BACKGROUND: Potentially inappropriate medication (PIM) use in the elderly is associated with increased risk of adverse drug reactions (ADRs), but there is limited information regarding PIM use in the intensive care unit (ICU) setting. OBJECTIVE: The aim of the study is to describe the prevalence and factors associated with the use of PIM and the occurrence of PIM-related adverse reactions in the critically ill elderly. METHODS: This study enrolled all critically ill older adults (60 years or more) admitted to medical or cardiovascular ICUs between January and December 2013, in a large tertiary teaching hospital...
October 2016: Pharmacy Practice
https://www.readbyqxmd.com/read/28039932/potentially-inappropriate-medications-in-elderly-japanese-patients-effects-of-pharmacists-assessment-and-intervention-based-on-screening-tool-of-older-persons-potentially-inappropriate-prescriptions-criteria-ver-2
#13
T Kimura, F Ogura, K Yamamoto, A Uda, T Nishioka, M Kume, H Makimoto, I Yano, M Hirai
WHAT IS KNOWN AND OBJECTIVES: The Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (stopp) criteria were updated in 2014 (stopp criteria ver.2), but few studies have evaluated the usefulness of stopp criteria in elderly patients. This prospective observational study evaluated the prevalence of potentially inappropriate medications (PIMs), and the efficacy of hospital pharmacists' assessment and intervention based on stopp criteria ver.2. METHODS: The study was conducted at three medical units of Kobe University Hospital between April 2015 and March 2016...
December 31, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28009450/multi-compartment-compliance-aids-in-the-community-the-prevalence-of-potentially-inappropriate-medications
#14
David Counter, Derek Stewart, Joan MacLeod, James S Mclay
AIMS: To assess the prevalence of potentially inappropriate medications (PIM) use in a population of community-based multi-compartment compliance aid (MCA) users in North- Scotland. METHODS: Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1(st) June to 31(st) October 2014, together with concurrently prescribed medications, patient demographics and Carstairs Index of social deprivation were recorded. Drug-specific quality indicators for PIMs from the Swedish National Board of Health and Welfare were applied and bivariate logistic regression analysis used to assess for associations with demographic variables...
December 23, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28008599/screening-tool-of-older-person-s-prescriptions-screening-tools-to-alert-doctors-to-right-treatment-medication-criteria-modified-for-u-s-nursing-home-setting
#15
Dmitry Khodyakov, Aileen Ochoa, Brianne L Olivieri-Mui, Carla Bouwmeester, Barbara J Zarowitz, Meenakshi Patel, Diana Ching, Becky Briesacher
OBJECTIVES: To develop a set of prescribing indicators measurable with available data from electronic nursing home (NH) databases by adapting the European-based 2014 Screening Tool of Older Person's Prescriptions (STOPP) and Screening Tools to Alert Doctors to Right Treatment (START) criteria of potentially inappropriate and underused medications for the U.S. SETTING: HASH(0x2dcd150) DESIGN: A two-stage expert panel process. In the first stage, the investigator team reviewed 114 criteria for compatibility and measurability...
December 23, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27999470/prevalence-of-potentially-inappropriate-medications-and-prescription-cost-analysis-among-older-cardiac-patients-in-an-outpatient-department-of-a-tertiary-care-hospital-in-india
#16
Kartik Nitinbhai Shah, Harsh Manishbhai Joshi, Rohan Piyushkumar Christian, Kamlesh Prahaladbhai Patel, Supriya Dipak Malhotra
AIMS: The aim of this study is to evaluate potentially inappropriate medications (PIMs) in the elderly at cardiology outpatient department (OPD) of a tertiary care teaching hospital using Beers criteria and to find the direct cost burden of PIMs. MATERIALS AND METHODS: The present study was an observational cross-sectional study. Prescriptions of the patients' aged ≥65 years were collected from the cardiology OPD and were analyzed. PIMs were identified with the help of Beers 2012 criteria...
September 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/27999034/sustained-impact-of-a-computer-assisted-antimicrobial-stewardship-intervention-on-antimicrobial-use-and-length-of-stay
#17
Vincent Nault, Jacques Pepin, Mathieu Beaudoin, Julie Perron, Jean-Marie Moutquin, Louis Valiquette
OBJECTIVES: Prospective audit and feedback interventions are the core components of an antimicrobial stewardship programme. Herein, we describe the sustained impact of an antimicrobial stewardship programme, based on a novel clinical decision-support system (Antimicrobial Prescription Surveillance System; APSS), on antimicrobial use and costs, hospital length of stay (LOS) in days and the proportion of inappropriate antimicrobial prescriptions. METHODS: A quasi-experimental, retrospective study was conducted using interrupted time series between 2008 and 2013...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27998498/tb-management-by-private-practitioners-is-it-bad-everywhere
#18
P S Rakesh, Shibu Balakrishnan, S Jayasankar, R V Asokan
INTRODUCTION: Poor prescribing practice is alleged to be one of the major factors fuelling the drug-resistant tuberculosis (DR TB) emergence. A study in Mumbai revealed the extent of inappropriate tuberculosis (TB) management practices of private practitioners and discussed that with the context of high DR TB. Kerala is rated among the well performing States in India as far as TB control is concerned with evidences for a lower level of TB transmission and DR TB. The current study was done in Kerala State to assess the prescribing practices of private sector doctors in the treatment of TB...
October 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27968914/massive-misuse-of-antibiotics-by-university-students-in-china-a-cross-sectional-survey
#19
Xiao-Min Wang, Xu-Dong Zhou, Therese Hesketh
BACKGROUND: Antimicrobial resistance is one of the greatest threats to global population health this century, and is a major contributor to rising healthcare costs worldwide. The primary cause of this resistance is antibiotic misuse, especially routine inappropriate use of antibiotics for self-limiting illnesses. In China, over prescribing of antibiotics is pervasive leading to very high and increasing rates of antimicrobial resistance in both hospital-acquired and community-acquired infections...
October 2016: Lancet
https://www.readbyqxmd.com/read/27968757/a-pilot-study-exploring-the-plasma-potassium-variation-in-dogs-undergoing-steroid-therapy-and-its-clinical-importance
#20
Marina Baltar, Alexandra Costa, L Miguel Carreira
In most situations in veterinary medicine, glucocorticoids are the drugs of choice used, that is, to reduce the inflammatory response or limit an inappropriate immune response. Their use in long-term therapy may cause side effects that may weaken the patient. The aim of the study was to evaluate possible variations in the plasma potassium concentrations and their clinical relevance in dogs undergoing steroid therapy with methylprednisolone in anti-inflammatory doses. The study used a sample of 21 dogs (n = 21) presented for consultation, with a clinical condition requiring a corticosteroid therapeutic protocol with an anti-inflammatory dose of methylprednisolone...
June 2016: Topics in Companion Animal Medicine
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